Pub Date : 2022-12-31DOI: 10.5584/jiomics.v12i2.216
J. D. de Jesus
Background: SARS-CoV-2 virus is currently one of the main causes of death worldwide. Several studies have suggested that various trace elements play a vital role in the immune activity during viral infection, being an important tool to understand the SARS-CoV-2 infection and its systemic behavior, which affects different organs. Purpose: To summarize recent studies that report the effect of trace elements on the immune system and their role in fighting SARS-CoV-2 infection, presenting potential biochemical routes. Method: The main databases (ScienceDirect®, Scopus®, PubMed®) were consulted to search for works published up to October 2022, focusing on the role of trace elements in the immune activity against viral infection, including SARS-CoV-2. Conclusion: Many elements can act both in the activation of the host’s immune activity and in the survival of the virus since these processes occur with the participation of essential metals to guarantee the integrity of their functions. However, the relationship between trace elements and viral infection is complex, and requires further studies, mainly, focusing on the systemic behavior of SARS-CoV-2 infection.
{"title":"Essential elements as critical players against SARS-CoV-2 activity","authors":"J. D. de Jesus","doi":"10.5584/jiomics.v12i2.216","DOIUrl":"https://doi.org/10.5584/jiomics.v12i2.216","url":null,"abstract":"Background: SARS-CoV-2 virus is currently one of the main causes of death worldwide. Several studies have suggested that various trace elements play a vital role in the immune activity during viral infection, being an important tool to understand the SARS-CoV-2 infection and its systemic behavior, which affects different organs. \u0000Purpose: To summarize recent studies that report the effect of trace elements on the immune system and their role in fighting SARS-CoV-2 infection, presenting potential biochemical routes. \u0000Method: The main databases (ScienceDirect®, Scopus®, PubMed®) were consulted to search for works published up to October 2022, focusing on the role of trace elements in the immune activity against viral infection, including SARS-CoV-2. \u0000Conclusion: Many elements can act both in the activation of the host’s immune activity and in the survival of the virus since these processes occur with the participation of essential metals to guarantee the integrity of their functions. However, the relationship between trace elements and viral infection is complex, and requires further studies, mainly, focusing on the systemic behavior of SARS-CoV-2 infection.","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48284219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-03DOI: 10.5584/jiomics.v12i1.212
Saranya Joshi, Lokesh Kumar, K. Rauthan, Sudhir Kumar
Wuchereria bancrofti and Brugia malayi are the filarial worms belonging to phylum Nematoda and cause lymphatic filariasis (LF) disease in humans. W. bancrofti and B. malayi are Wolbachia dependent organisms while C. elegans is free living Wolbachia independent nematode. In order to investigate the conserved regions present in the mitochondrial genome of these organisms, the complete mitochondrial (mt) genomes of W. bancrofti and B. malayi having size 13,636 bp and 13,657 bp in length, respectively are compared with C. elegans (13794 bp). These mt genomes were similar to each other in respect of their size, AT content and encode the same 12 PCGs (nad1–6, nad4L, cytb, cox1–3, and atp6). Complete mt genome alignment identified 13 conserved regions in each of the organisms with some of these regions unique only to one organism. Phylogenetic analysis using the mt genome showed a close relationship between W. bancrofti and B. malayi but showed a common early ancestor with the C. elegans emphasizing an early evolutionary divergence.
{"title":"Comparative analyses of the complete mitochondrial genomes of the two filarial worms Wuchereria bancrofti & Brugia malayi with Caenorhabditis elegans","authors":"Saranya Joshi, Lokesh Kumar, K. Rauthan, Sudhir Kumar","doi":"10.5584/jiomics.v12i1.212","DOIUrl":"https://doi.org/10.5584/jiomics.v12i1.212","url":null,"abstract":"Wuchereria bancrofti and Brugia malayi are the filarial worms belonging to phylum Nematoda and cause lymphatic filariasis (LF) disease in humans. W. bancrofti and B. malayi are Wolbachia dependent organisms while C. elegans is free living Wolbachia independent nematode. In order to investigate the conserved regions present in the mitochondrial genome of these organisms, the complete mitochondrial (mt) genomes of W. bancrofti and B. malayi having size 13,636 bp and 13,657 bp in length, respectively are compared with C. elegans (13794 bp). These mt genomes were similar to each other in respect of their size, AT content and encode the same 12 PCGs (nad1–6, nad4L, cytb, cox1–3, and atp6). Complete mt genome alignment identified 13 conserved regions in each of the organisms with some of these regions unique only to one organism. Phylogenetic analysis using the mt genome showed a close relationship between W. bancrofti and B. malayi but showed a common early ancestor with the C. elegans emphasizing an early evolutionary divergence. ","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45934652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-23DOI: 10.5584/jiomics.v12i1.211
J. Capelo, C. Lodeiro, R. Dhir, N. Kravchenko‐Balasha, H. Santos
José L. Capelo *, Carlos Lodeiro, Rajiv Dhir, Nataly Kravchenko-Balasha, Hugo M. Santos* 1 (Bio)Chemistry & Omics, BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal; 2 PROTEOMASS Scientific Society, Madan Parque, Rua dos Inventores, 2825-182 Caparica, Portugal; 3 Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; 4 Department for Bio-medical Research, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, 91120, Israel
jos L. Capelo *， Carlos Lodeiro, Rajiv Dhir, Nataly Kravchenko-Balasha, Hugo M. Santos* 1(生物)化学与组学，BIOSCOPE研究小组，LAQV-REQUIMTE，里斯本大学NOVA科学与技术学院化学系，2829-516，葡萄牙卡帕里卡;2 PROTEOMASS科学学会，Madan Parque, Rua dos inventres, 2825-182 Caparica，葡萄牙;3匹兹堡大学医学中心病理学系，美国宾夕法尼亚州匹兹堡;4耶路撒冷希伯来大学口腔科学研究所生物医学研究所，耶路撒冷，91120，以色列
{"title":"Prescriptomics: the next frontier in medicine","authors":"J. Capelo, C. Lodeiro, R. Dhir, N. Kravchenko‐Balasha, H. Santos","doi":"10.5584/jiomics.v12i1.211","DOIUrl":"https://doi.org/10.5584/jiomics.v12i1.211","url":null,"abstract":"José L. Capelo *, Carlos Lodeiro, Rajiv Dhir, Nataly Kravchenko-Balasha, Hugo M. Santos* 1 (Bio)Chemistry & Omics, BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal; 2 PROTEOMASS Scientific Society, Madan Parque, Rua dos Inventores, 2825-182 Caparica, Portugal; 3 Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; 4 Department for Bio-medical Research, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, 91120, Israel","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43583973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.5584/jiomics.v11i2.205
J. Capelo
SPECIAL ISSUE: SELECTED ABSTRACTS OF OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN SPLICING (SPLICING 2021) and OF THE VII INTERNATIONAL CAPARICA CONFERENCE ON ANALYTICAL PROTEOMICS (ICAP 2021)
{"title":"SPECIAL ISSUE: SELECTED ABSTRACTS OF OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN SPLICING (SPLICING 2021) and OF THE VII INTERNATIONAL CAPARICA CONFERENCE ON ANALYTICAL PROTEOMICS (ICAP 2021)","authors":"J. Capelo","doi":"10.5584/jiomics.v11i2.205","DOIUrl":"https://doi.org/10.5584/jiomics.v11i2.205","url":null,"abstract":"SPECIAL ISSUE: SELECTED ABSTRACTS OF OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN SPLICING (SPLICING 2021) and OF THE VII INTERNATIONAL CAPARICA CONFERENCE ON ANALYTICAL PROTEOMICS (ICAP 2021)","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48876184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.5584/jiomics.v11i2.207
J. D. de Jesus, M. Arruda
Biomarkers are important tools in the medical field, once they allow better prediction, characterization, and treatment of diseases. In this scenario, it is essential that biomarkers are highly accurate. Thus, biomarker validation is an essential part of ensuring the effectiveness of a biomarker. Validation of biomarkers is the process by which biomarkers are evaluated for accuracy and consistency, as well as their ability to inform the condition of health or disease. Although, there is no unique measure that can be used to determine the validity for all biomarkers, there are general criteria that all biomarkers must meet to be useful. In this work, we review the definition of biomarkers and discuss the validity components. We then critically discuss the main methods used to validate biomarkers and consider some examples of biomarkers of the diseases which most killer in the world (cardiovascular diseases, cancer, and viral infections), highlighting the potential biochemical pathways of these biomarkers in the biological system. In addition, we also comment on the omic strategies used in the biomarker discovery process and conclude with information about perspectives in biomarker validation through imaging techniques.
{"title":"Human disease biomarkers: challenges, advances, and trends in their validation","authors":"J. D. de Jesus, M. Arruda","doi":"10.5584/jiomics.v11i2.207","DOIUrl":"https://doi.org/10.5584/jiomics.v11i2.207","url":null,"abstract":"Biomarkers are important tools in the medical field, once they allow better prediction, characterization, and treatment of diseases. In this scenario, it is essential that biomarkers are highly accurate. Thus, biomarker validation is an essential part of ensuring the effectiveness of a biomarker. Validation of biomarkers is the process by which biomarkers are evaluated for accuracy and consistency, as well as their ability to inform the condition of health or disease. Although, there is no unique measure that can be used to determine the validity for all biomarkers, there are general criteria that all biomarkers must meet to be useful. In this work, we review the definition of biomarkers and discuss the validity components. We then critically discuss the main methods used to validate biomarkers and consider some examples of biomarkers of the diseases which most killer in the world (cardiovascular diseases, cancer, and viral infections), highlighting the potential biochemical pathways of these biomarkers in the biological system. In addition, we also comment on the omic strategies used in the biomarker discovery process and conclude with information about perspectives in biomarker validation through imaging techniques.","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43829455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-30DOI: 10.5584/jiomics.v11i1.199
J. Capelo
SPECIAL ISSUE: SELECTED ABSTRACTS OF THE V INTERNATIONAL CAPARICA CONFERENCE ON ULTRASONIC-BASED APPLICATION FROM ANALYSIS TO SYNTHESIS (ULTRASONICS 2021)
特刊:第五届超声从分析到合成应用国际卡帕里卡会议(ultrasonics 2021)精选摘要
{"title":"SPECIAL ISSUE: SELECTED ABSTRACTS OF THE V INTERNATIONAL CAPARICA CONFERENCE ON ULTRASONIC-BASED APPLICATION FROM ANALYSIS TO SYNTHESIS (ULTRASONICS 2021)","authors":"J. Capelo","doi":"10.5584/jiomics.v11i1.199","DOIUrl":"https://doi.org/10.5584/jiomics.v11i1.199","url":null,"abstract":"SPECIAL ISSUE: SELECTED ABSTRACTS OF THE V INTERNATIONAL CAPARICA CONFERENCE ON ULTRASONIC-BASED APPLICATION FROM ANALYSIS TO SYNTHESIS (ULTRASONICS 2021)","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70838644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-30DOI: 10.5584/jiomics.v11i1.200
J. Capelo
SPECIAL ISSUE: SELECTED ABSTRACTS OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN ANTIBIOTIC RESISTANCE (IC2AR 2021)
特刊：第四届加拿大抗生素耐药性国际会议（IC2AR 2021）摘要精选
{"title":"SPECIAL ISSUE: SELECTED ABSTRACTS OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN ANTIBIOTIC RESISTANCE (IC2AR 2021)","authors":"J. Capelo","doi":"10.5584/jiomics.v11i1.200","DOIUrl":"https://doi.org/10.5584/jiomics.v11i1.200","url":null,"abstract":"SPECIAL ISSUE: SELECTED ABSTRACTS OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN ANTIBIOTIC RESISTANCE (IC2AR 2021)","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49068914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.5584/jiomics.v10i3.355
J. Capelo
{"title":"Special Issue: Selected Abstracts of the III International Caparica Conference in Splicing 2020","authors":"J. Capelo","doi":"10.5584/jiomics.v10i3.355","DOIUrl":"https://doi.org/10.5584/jiomics.v10i3.355","url":null,"abstract":"","PeriodicalId":37675,"journal":{"name":"Journal of Integrated OMICS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47892433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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