Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.045
O. Kaabia, L. Mkaouer
The scarcity of in-depth studies on female masturbation testifies to the lack of attention paid to this crucial subject and to the cultural hurdles to talking about such a subject. This absence of evidence prevents healthcare practitioners from understanding women's experiences, needs, and challenges regarding their sexuality and sexual autonomy. It is therefore imperative to fill this knowledge gap with research studies that look at the cultural, social, and religious specificities specific to female masturbation. The main objective of this study is to assess the knowledge of women regarding female masturbation taking into consideration their cultural, social, and religious backgrounds. We present a cross-sectional study based on an online 15-item questionnaire posted once per week, 5 weeks in a row from March 14, 2023. The online self-administered questionnaire was presented in the local written dialect. The questionnaire was divided into a sociodemographic section, a general knowledge assessment of genitalia and the sexual female function, and a section about the misconceptions and knowledge about female masturbation. All participants were self-designated female participants over the age of 18, recruited from sports centers' Facebook and Instagram pages. The study included 213 participants, 82% of who have attended high education institutions, and 70% were single. The mean age was 25 [18, 45]. Internet was the participants' primary informational source in 64%. Friends were the second source of information with 15%. With regard to the participants' knowledge, the results of the study reveal a diversity of levels of knowledge within our population. Some participants demonstrated a limited or incorrect understanding of female masturbation, often influenced by cultural, and religious beliefs or preconceived ideas. This inaccurate knowledge contributes to the spread of negative stereotypes and judgments about practice. It is important to recognize that female masturbation often remains a difficult subject to discuss and is surrounded by social taboos. In light of our findings, it is clear that additional efforts are needed to promote better understanding and acceptance of female masturbation through comprehensive sexuality education programs. No.
{"title":"(048) Women's Knowledge about Female Masturbation","authors":"O. Kaabia, L. Mkaouer","doi":"10.1093/jsxmed/qdae002.045","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.045","url":null,"abstract":"\u0000 \u0000 \u0000 The scarcity of in-depth studies on female masturbation testifies to the lack of attention paid to this crucial subject and to the cultural hurdles to talking about such a subject. This absence of evidence prevents healthcare practitioners from understanding women's experiences, needs, and challenges regarding their sexuality and sexual autonomy. It is therefore imperative to fill this knowledge gap with research studies that look at the cultural, social, and religious specificities specific to female masturbation.\u0000 \u0000 \u0000 \u0000 The main objective of this study is to assess the knowledge of women regarding female masturbation taking into consideration their cultural, social, and religious backgrounds.\u0000 \u0000 \u0000 \u0000 We present a cross-sectional study based on an online 15-item questionnaire posted once per week, 5 weeks in a row from March 14, 2023. The online self-administered questionnaire was presented in the local written dialect. The questionnaire was divided into a sociodemographic section, a general knowledge assessment of genitalia and the sexual female function, and a section about the misconceptions and knowledge about female masturbation. All participants were self-designated female participants over the age of 18, recruited from sports centers' Facebook and Instagram pages.\u0000 \u0000 \u0000 \u0000 The study included 213 participants, 82% of who have attended high education institutions, and 70% were single. The mean age was 25 [18, 45]. Internet was the participants' primary informational source in 64%. Friends were the second source of information with 15%. With regard to the participants' knowledge, the results of the study reveal a diversity of levels of knowledge within our population. Some participants demonstrated a limited or incorrect understanding of female masturbation, often influenced by cultural, and religious beliefs or preconceived ideas. This inaccurate knowledge contributes to the spread of negative stereotypes and judgments about practice.\u0000 \u0000 \u0000 \u0000 It is important to recognize that female masturbation often remains a difficult subject to discuss and is surrounded by social taboos. In light of our findings, it is clear that additional efforts are needed to promote better understanding and acceptance of female masturbation through comprehensive sexuality education programs.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"38 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.207
A. Wexler, A. Dubinskaya, J. Suyama, B. Komisaruk, J. Anger, K. Eilber
Sexual health is a fundamental dimension of overall human well-being, deeply intertwined with physical health, interpersonal relationships, and the overall quality of life. However, sexual dysfunction is prevalent among both men and women. Despite it's common occurrence, it often remains underdiagnosed and undertreated. In an attempt to improve the treatment landscape and offer new hope for those suffering from sexual dysfunction, researchers have turned to explore unconventional therapies, examining substances beyond the traditional medicinal spectrum. Compounds typically associated with recreational use, like cannabis and LSD, have been subjects of recent studies, exploring their potential therapeutic value. Notably, 3,4-Methylenedioxymethamphetamine (MDMA), colloquially known as 'Ecstasy,' has been attracting significant scientific interest. This synthetic amphetamine is known for its psychostimulant and entactogenic properties, and anecdotally noted for its potential effects on the sexual response cycle. To examine the existing literature on the effects of MDMA on male and female sexual responsiveness and the potential role of MDMA in treating sexual dysfunction of various etiologies. We conducted a systematic review on the effects of MDMA on each domain of the female and male sexual response cycles. PubMed, MEDLINE, and EMBASE were queried, and results were screened using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Search terms utilized were “MDMA” or “Ecstasy” in combination with “desire,” “arousal”, “lubrication”, “orgasm”, “pleasure”, “libido”, “erection” and “ejaculation”. Inclusion criteria for this review were MDMA use by study subjects, sexual outcomes in at least one domain of the female and/or male sexual response cycles were described and measured. Randomized control trials (RCT), cohort studies (both prospective and retrospective), surveys, and literature reviews published between January 2000 and June 2022 were included. We identified 181 studies, of which six met criteria for assessment of the female sexual response cycle and eight met criteria for assessment of the male sexual response cycle. Four of six studies reported increased sexual desire with MDMA use among women. Arousal and lubrication were improved with MDMA use in three of four studies, but they were not affected in one randomized control study. In men, seven studies evaluated the effects of MDMA on desire and/or arousal, five studies measured impact on erection, three on orgasm, and two on ejaculation. Sixty percent of interview-based studies reported increased sexual desire in men, while 40% reported mixed or no effect. Two studies reported impairment of erection, two reported mixed effects, and one reported “fear of erection impairment.” In both men and women, all studies evaluating orgasm reported delay in achieving orgasm, but increased intensity and pleasure if achieved. Primary outcome meas
{"title":"(236) Does MDMA Have Treatment Potential in Sexual Dysfunction? A Systematic Review of Outcomes Across the Female and Male Sexual Response Cycles","authors":"A. Wexler, A. Dubinskaya, J. Suyama, B. Komisaruk, J. Anger, K. Eilber","doi":"10.1093/jsxmed/qdae002.207","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.207","url":null,"abstract":"\u0000 \u0000 \u0000 Sexual health is a fundamental dimension of overall human well-being, deeply intertwined with physical health, interpersonal relationships, and the overall quality of life. However, sexual dysfunction is prevalent among both men and women. Despite it's common occurrence, it often remains underdiagnosed and undertreated. In an attempt to improve the treatment landscape and offer new hope for those suffering from sexual dysfunction, researchers have turned to explore unconventional therapies, examining substances beyond the traditional medicinal spectrum. Compounds typically associated with recreational use, like cannabis and LSD, have been subjects of recent studies, exploring their potential therapeutic value. Notably, 3,4-Methylenedioxymethamphetamine (MDMA), colloquially known as 'Ecstasy,' has been attracting significant scientific interest. This synthetic amphetamine is known for its psychostimulant and entactogenic properties, and anecdotally noted for its potential effects on the sexual response cycle.\u0000 \u0000 \u0000 \u0000 To examine the existing literature on the effects of MDMA on male and female sexual responsiveness and the potential role of MDMA in treating sexual dysfunction of various etiologies.\u0000 \u0000 \u0000 \u0000 We conducted a systematic review on the effects of MDMA on each domain of the female and male sexual response cycles. PubMed, MEDLINE, and EMBASE were queried, and results were screened using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Search terms utilized were “MDMA” or “Ecstasy” in combination with “desire,” “arousal”, “lubrication”, “orgasm”, “pleasure”, “libido”, “erection” and “ejaculation”. Inclusion criteria for this review were MDMA use by study subjects, sexual outcomes in at least one domain of the female and/or male sexual response cycles were described and measured. Randomized control trials (RCT), cohort studies (both prospective and retrospective), surveys, and literature reviews published between January 2000 and June 2022 were included.\u0000 \u0000 \u0000 \u0000 We identified 181 studies, of which six met criteria for assessment of the female sexual response cycle and eight met criteria for assessment of the male sexual response cycle. Four of six studies reported increased sexual desire with MDMA use among women. Arousal and lubrication were improved with MDMA use in three of four studies, but they were not affected in one randomized control study. In men, seven studies evaluated the effects of MDMA on desire and/or arousal, five studies measured impact on erection, three on orgasm, and two on ejaculation. Sixty percent of interview-based studies reported increased sexual desire in men, while 40% reported mixed or no effect. Two studies reported impairment of erection, two reported mixed effects, and one reported “fear of erection impairment.” In both men and women, all studies evaluating orgasm reported delay in achieving orgasm, but increased intensity and pleasure if achieved. Primary outcome meas","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140283303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.212
M. El-Bahnasawy, T. Alzahrani, M. Alanazi, A. Albalawi
Brucellosis, which is also called Mediterranean or Malta fever, is an endemic enzootic disease and can involve various organ systems. It is commonly endemic in the Mediterranean countries and the Middle East. Epididymo-orchitis is a focal form of human brucellosis. Brucella species cause granulomatous orchitis usually presenting as an acute or chronic unilateral swelling of the testis. Patients rarely present to the clinicians with acute scrotum due to Brucellosis Epididymo-Orchitis (BEO) as an initial finding. Our aim is to estimate the prevalence of the BEO among the cases diagnosed with Epididymoorchitis in our hospital over the last four years. Retrospective study from 2015–2018 involving all cases diagnosed with Epididymoorchitis in our hospital. A total of 92 cases of Epididymoorchitis were diagnosed during this period. These cases presented to ER complaining of severe unilateral scrotal pain, swelling, fever and sweating. Local examination showed swollen enlarged testis and epididymis with marked tenderness. Brucella serologic test for both B abortus and B melitensis were requested routinely for all cases of epididymo-orchitis. Scrotal Doppler ultrasonographic examination was requested at initial diagnosis and after 2 weeks to exclude abscess formation. Out of 92 cases, 8 were diagnosed to have brucellosis (8.7%). The median age of patients was 32 years (range, 18–41 years). All patients had positive history of consuming unpasteurized dairy products, which is a risk factor for brucellosis. The diagnosis of brucellosis was made via positive serological testing results (Brucella abortus and melitensis). One case showed testicular abscess formation. All cases were given combination of tetracyclin and rifampicin for 6–12 weeks. Two cases required prolonged hospital stay due to testicular abscess formation in one and development of Brucellosis spondylitis in the other. Gentamycin was added for one week in such cases. In endemic regions for brucellosis, we have to consider it in the workup of all cases of epididiymo-orchitis. The diagnosis is easy by positive serology tests. Positive cases need special antibiotic combination protocol for longer time and close monitoring for development of local complications or other systemic brucellosis manifestations No.
{"title":"(245) Epididymo-Orchitis as the First Presentation of Brucellosis in an Endemic Area","authors":"M. El-Bahnasawy, T. Alzahrani, M. Alanazi, A. Albalawi","doi":"10.1093/jsxmed/qdae002.212","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.212","url":null,"abstract":"\u0000 \u0000 \u0000 Brucellosis, which is also called Mediterranean or Malta fever, is an endemic enzootic disease and can involve various organ systems. It is commonly endemic in the Mediterranean countries and the Middle East. Epididymo-orchitis is a focal form of human brucellosis. Brucella species cause granulomatous orchitis usually presenting as an acute or chronic unilateral swelling of the testis. Patients rarely present to the clinicians with acute scrotum due to Brucellosis Epididymo-Orchitis (BEO) as an initial finding.\u0000 \u0000 \u0000 \u0000 Our aim is to estimate the prevalence of the BEO among the cases diagnosed with Epididymoorchitis in our hospital over the last four years.\u0000 \u0000 \u0000 \u0000 Retrospective study from 2015–2018 involving all cases diagnosed with Epididymoorchitis in our hospital. A total of 92 cases of Epididymoorchitis were diagnosed during this period. These cases presented to ER complaining of severe unilateral scrotal pain, swelling, fever and sweating. Local examination showed swollen enlarged testis and epididymis with marked tenderness. Brucella serologic test for both B abortus and B melitensis were requested routinely for all cases of epididymo-orchitis. Scrotal Doppler ultrasonographic examination was requested at initial diagnosis and after 2 weeks to exclude abscess formation.\u0000 \u0000 \u0000 \u0000 Out of 92 cases, 8 were diagnosed to have brucellosis (8.7%). The median age of patients was 32 years (range, 18–41 years). All patients had positive history of consuming unpasteurized dairy products, which is a risk factor for brucellosis. The diagnosis of brucellosis was made via positive serological testing results (Brucella abortus and melitensis). One case showed testicular abscess formation. All cases were given combination of tetracyclin and rifampicin for 6–12 weeks. Two cases required prolonged hospital stay due to testicular abscess formation in one and development of Brucellosis spondylitis in the other. Gentamycin was added for one week in such cases.\u0000 \u0000 \u0000 \u0000 In endemic regions for brucellosis, we have to consider it in the workup of all cases of epididiymo-orchitis. The diagnosis is easy by positive serology tests. Positive cases need special antibiotic combination protocol for longer time and close monitoring for development of local complications or other systemic brucellosis manifestations\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"210 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.083
J. E. Rodríguez Martínez, R. Dadian, A. García Gómez
Around 40 percent of women in Spain are unable to achieve orgasm during coital relations, although most can do so through other means. Many of these women do not seek treatment, even though this situation may affect their sexual and relational life. Female Orgasm Disorder (FOD) treatment has seen little innovation since the 1980s. The growing acceptance, technological development, and focus on diversity have contributed to the flourishing of the sex toy industry. This sector has enabled the development of therapeutic devices that have already demonstrated usefulness in addressing other female and male sexual dysfunctions, often making treatments more Accessible. However, more scientific studies are needed on this topic. Present the results of the utility and safety of using a vibrating device in the management of situational female orgasm disorder (FOD) in a group of women from Spain. A case report study of an observational, descriptive, prospective nature, involving 19 women undergoing treatment, that meet criteria for lifelong, situational FOD from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) was conducted in Murcia, Spain, from January 2022 to July 2023. Patients were 18 years or older, generally healthy as evidenced by medical history, were sexually active, in a current relationship of 3 months or longer, and participation was voluntary. Patients did not meet criteria for PTSD, psychosis or dissociative disorders, depression or bipolar disorders, were not pregnant or in menopause and did not use drugs known to interfere with sexual functioning. Main outcome measures were assessed using the Female Sexual Function Index (FSFI) domain for orgasm at baseline and after 6 and 12 weeks, as well as the success rate of achieving orgasm during coital relations. Treatment consisted of an educational session where a vibrating device called Crescendo II® and its accompanying resource of different positions, Play Book was provided, along with instructions for using the device during coital relations. Patients had a mean age of 31.19 years (range 27–53). An improvement was observed in the average scores at six and twelve weeks in FSFI orgasmic domain, (mean pre = 1.62 (SD) = 0.42, mean post six weeks = 3.47 (SD) = 1.26, mean post twelve weeks = 3.43 (SD) = 1.25). The success rate (orgasm achievement during intercourse) at the end of the study was 90.47%. This case series suggests that the use of a vibration device could be an effective and safe therapeutic option for female situational anorgasmia in addition to reducing the length and cost of treatment. Future research with experimental designs should confirm the clear potential of the use of these devices in treating FOD and clarify issues related to the most appropriate amplitude and frequency of vibration, as well as the possible long-term effects of using these types of vibration devices in patients. Any of the authors act as a
{"title":"(091) Use of a Vibrating Device in the Management of Female Situational Anorgasmia: Prospective Case Series Study in Women from Southeastern Spain","authors":"J. E. Rodríguez Martínez, R. Dadian, A. García Gómez","doi":"10.1093/jsxmed/qdae002.083","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.083","url":null,"abstract":"\u0000 \u0000 \u0000 Around 40 percent of women in Spain are unable to achieve orgasm during coital relations, although most can do so through other means. Many of these women do not seek treatment, even though this situation may affect their sexual and relational life. Female Orgasm Disorder (FOD) treatment has seen little innovation since the 1980s. The growing acceptance, technological development, and focus on diversity have contributed to the flourishing of the sex toy industry. This sector has enabled the development of therapeutic devices that have already demonstrated usefulness in addressing other female and male sexual dysfunctions, often making treatments more Accessible. However, more scientific studies are needed on this topic.\u0000 \u0000 \u0000 \u0000 Present the results of the utility and safety of using a vibrating device in the management of situational female orgasm disorder (FOD) in a group of women from Spain.\u0000 \u0000 \u0000 \u0000 A case report study of an observational, descriptive, prospective nature, involving 19 women undergoing treatment, that meet criteria for lifelong, situational FOD from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) was conducted in Murcia, Spain, from January 2022 to July 2023. Patients were 18 years or older, generally healthy as evidenced by medical history, were sexually active, in a current relationship of 3 months or longer, and participation was voluntary. Patients did not meet criteria for PTSD, psychosis or dissociative disorders, depression or bipolar disorders, were not pregnant or in menopause and did not use drugs known to interfere with sexual functioning. Main outcome measures were assessed using the Female Sexual Function Index (FSFI) domain for orgasm at baseline and after 6 and 12 weeks, as well as the success rate of achieving orgasm during coital relations. Treatment consisted of an educational session where a vibrating device called Crescendo II® and its accompanying resource of different positions, Play Book was provided, along with instructions for using the device during coital relations.\u0000 \u0000 \u0000 \u0000 Patients had a mean age of 31.19 years (range 27–53). An improvement was observed in the average scores at six and twelve weeks in FSFI orgasmic domain, (mean pre = 1.62 (SD) = 0.42, mean post six weeks = 3.47 (SD) = 1.26, mean post twelve weeks = 3.43 (SD) = 1.25). The success rate (orgasm achievement during intercourse) at the end of the study was 90.47%.\u0000 \u0000 \u0000 \u0000 This case series suggests that the use of a vibration device could be an effective and safe therapeutic option for female situational anorgasmia in addition to reducing the length and cost of treatment. Future research with experimental designs should confirm the clear potential of the use of these devices in treating FOD and clarify issues related to the most appropriate amplitude and frequency of vibration, as well as the possible long-term effects of using these types of vibration devices in patients.\u0000 \u0000 \u0000 \u0000 Any of the authors act as a","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.104
A. El-Achkar, K. Khalaf Alla, T. Nguyen, M. Mahdi, R. Wang
In cases of non-infected malfunctioning Inflatable penile prosthesis (IPP) device, surgeon often opt to exchange all the device rather than the defective component for fear of increased infection rate and future mechanical dysfunction. To assess whether partial component exchange of IPP device has comparable outcomes to complete explant and replacement of IPP device with or without retained reservoir. A meta-analysis was completed in line with PRISMA 2020 and AMSTAR guidelines. A comprehensive search was done on MEDLINE (OVID), PubMed, and Cochrane Library electronic databases from their inceptions until May 2023, identifying studies that reported on outcomes and complications of revision surgery for non-infected malfunctioning IPP device. Three groups were compared: the first group underwent a single or two-component exchange, the second group had a complete explant replacement of the entire device, and the third group had replacement of all components with a drained and retained primary reservoir. A total of 9 articles were included in the analysis. 12,152 patients had complete replacement of their device, 128 had partial exchange of their device and 151 patients had “drained and retained” reservoir following revision. The mean age was similar among the 3 groups between 62–68 years. The median follows up time ranged between 12 and 79 months. Partial component ex change had a higher rate of mechanical failure 10.3% versus 1.3% and 2.3 % (p=0.03) for complete and “drain and retain” groups respectively. (Figure 1) Similarly, partial component exchange had higher peri-operative complications at 21.2% compared to complete replacement group 9.5% and “drain and retain” group 14.5% (p=0.022). However, the infection rate was similar among the three groups, 7.7%, 2.7% and 3.3% respectively (p= 0.301). (Figure 2) Partial component exchange during IPP revision has higher rates of perioperative complication and future mechanical failure but has similar rate of infection compared to complete component replacement with or without “drain and retain” of original reservoir. No.
{"title":"(114) A Comparative Meta-Analysis of Revision Strategies for Malfunctioning Inflatable Penile Prosthesis: Partial vs Complete Component Replacement With or Without Retained Reservoir","authors":"A. El-Achkar, K. Khalaf Alla, T. Nguyen, M. Mahdi, R. Wang","doi":"10.1093/jsxmed/qdae002.104","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.104","url":null,"abstract":"\u0000 \u0000 \u0000 In cases of non-infected malfunctioning Inflatable penile prosthesis (IPP) device, surgeon often opt to exchange all the device rather than the defective component for fear of increased infection rate and future mechanical dysfunction.\u0000 \u0000 \u0000 \u0000 To assess whether partial component exchange of IPP device has comparable outcomes to complete explant and replacement of IPP device with or without retained reservoir.\u0000 \u0000 \u0000 \u0000 A meta-analysis was completed in line with PRISMA 2020 and AMSTAR guidelines. A comprehensive search was done on MEDLINE (OVID), PubMed, and Cochrane Library electronic databases from their inceptions until May 2023, identifying studies that reported on outcomes and complications of revision surgery for non-infected malfunctioning IPP device. Three groups were compared: the first group underwent a single or two-component exchange, the second group had a complete explant replacement of the entire device, and the third group had replacement of all components with a drained and retained primary reservoir.\u0000 \u0000 \u0000 \u0000 A total of 9 articles were included in the analysis. 12,152 patients had complete replacement of their device, 128 had partial exchange of their device and 151 patients had “drained and retained” reservoir following revision. The mean age was similar among the 3 groups between 62–68 years. The median follows up time ranged between 12 and 79 months. Partial component ex change had a higher rate of mechanical failure 10.3% versus 1.3% and 2.3 % (p=0.03) for complete and “drain and retain” groups respectively. (Figure 1) Similarly, partial component exchange had higher peri-operative complications at 21.2% compared to complete replacement group 9.5% and “drain and retain” group 14.5% (p=0.022). However, the infection rate was similar among the three groups, 7.7%, 2.7% and 3.3% respectively (p= 0.301). (Figure 2)\u0000 \u0000 \u0000 \u0000 Partial component exchange during IPP revision has higher rates of perioperative complication and future mechanical failure but has similar rate of infection compared to complete component replacement with or without “drain and retain” of original reservoir.\u0000 \u0000 \u0000 \u0000 No.\u0000 \u0000 \u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.134
D. Moon, S. Ahn, H. S. Lee, S. B. Cho, S. J. Moon, W. K. Hwang, H J Kim
Human papillomavirus (HPV) prevalence and genotype distribution are different between various nations and regions. Additionally, previous studies have mainly focused on HPV infection in western female and epidemiological studies of HPV infection in regional populations have been rarely reported. The lack of information on the HPV genotype distribution of the regional population in each individual country or region raises questions about the effectiveness of the current 9-valent vaccination. To assess the prevalence and genotype of HPV(+) Korean and to know whether currently available 9-valent vaccine can cover the most prevalent and high risk genotype as HPV vaccine in Korean. Between January 2014 to June 2022, samples of 44,065 men (Study I, M) and 564,499 females (Study II, F), who were volunteered for testing or recommended by a clinician, were tested for HPV detection and genotyping. Samples were collected swabs from the pap smear test. HPV detection and typing were conducted using the Anyplex™ II HPV 28 Detection system, which detects 19 high-risk (HR) HPVs and 9 low-risk (LR) HPVs. In Study I & Study II, overall prevalence were 59.7% (M), 44.3%(F), prevalence of HR were 30.6%(M), 37.5%(F) and LR HPVs were 50.1%(M), 18.3%(F), respectively. Overall HPV prevalence was higher in teens (34.1% in M and 58.3% in F) and 20s (33.8% in M and 51.9% in F) with age [Table 1]. The most prevalent genotypes of HR were 16 (5.2%), 53 (4.6%), 51 (4.2%), 52 (3.8%), 58 (3.7%), 39(3.6%) and 66(3.4%) in Study I. In Study II of Female, the most prevalent genotypes of HR were 52 (7.1%), 53 (6.2%), 58 (5.0%), 68 (4.8%), and 16 (4.3%). In Study I of 26,299 men with HPV infection, 9,259 (35.2%) had a genotype with HR; 53 (4.6%), 51 (4.2%), 39(3.6%) and 66(3.4%), which could not prevented by the 9-valent vaccine. In Study II of 211,883 females with HPV infection, 72,252 (34.1%) had a genotype with HR, 68 (4.8%), 51 (4.1%), 39 (3.8%), and 56 (3.7%) which could not be prevented by the 9-valent vaccine. In this study, Korea male and female aged under 30 years showed a high prevalence of HR HPVs. In both Male and Female groups, a significant number of HR HPVs infections were not prevented by 9-valent vaccine. Based on this result, it is necessary to develop nation-specific HPV vaccination for Korean. Further, this approach can be applied in other countries. No.
{"title":"(148) The Prevalence and Genotype Distribution of Human Papillomaviruses in Korean","authors":"D. Moon, S. Ahn, H. S. Lee, S. B. Cho, S. J. Moon, W. K. Hwang, H J Kim","doi":"10.1093/jsxmed/qdae002.134","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.134","url":null,"abstract":"\u0000 \u0000 \u0000 Human papillomavirus (HPV) prevalence and genotype distribution are different between various nations and regions. Additionally, previous studies have mainly focused on HPV infection in western female and epidemiological studies of HPV infection in regional populations have been rarely reported. The lack of information on the HPV genotype distribution of the regional population in each individual country or region raises questions about the effectiveness of the current 9-valent vaccination.\u0000 \u0000 \u0000 \u0000 To assess the prevalence and genotype of HPV(+) Korean and to know whether currently available 9-valent vaccine can cover the most prevalent and high risk genotype as HPV vaccine in Korean.\u0000 \u0000 \u0000 \u0000 Between January 2014 to June 2022, samples of 44,065 men (Study I, M) and 564,499 females (Study II, F), who were volunteered for testing or recommended by a clinician, were tested for HPV detection and genotyping. Samples were collected swabs from the pap smear test. HPV detection and typing were conducted using the Anyplex™ II HPV 28 Detection system, which detects 19 high-risk (HR) HPVs and 9 low-risk (LR) HPVs.\u0000 \u0000 \u0000 \u0000 In Study I & Study II, overall prevalence were 59.7% (M), 44.3%(F), prevalence of HR were 30.6%(M), 37.5%(F) and LR HPVs were 50.1%(M), 18.3%(F), respectively. Overall HPV prevalence was higher in teens (34.1% in M and 58.3% in F) and 20s (33.8% in M and 51.9% in F) with age [Table 1]. The most prevalent genotypes of HR were 16 (5.2%), 53 (4.6%), 51 (4.2%), 52 (3.8%), 58 (3.7%), 39(3.6%) and 66(3.4%) in Study I. In Study II of Female, the most prevalent genotypes of HR were 52 (7.1%), 53 (6.2%), 58 (5.0%), 68 (4.8%), and 16 (4.3%). In Study I of 26,299 men with HPV infection, 9,259 (35.2%) had a genotype with HR; 53 (4.6%), 51 (4.2%), 39(3.6%) and 66(3.4%), which could not prevented by the 9-valent vaccine. In Study II of 211,883 females with HPV infection, 72,252 (34.1%) had a genotype with HR, 68 (4.8%), 51 (4.1%), 39 (3.8%), and 56 (3.7%) which could not be prevented by the 9-valent vaccine.\u0000 \u0000 \u0000 \u0000 In this study, Korea male and female aged under 30 years showed a high prevalence of HR HPVs. In both Male and Female groups, a significant number of HR HPVs infections were not prevented by 9-valent vaccine. Based on this result, it is necessary to develop nation-specific HPV vaccination for Korean. Further, this approach can be applied in other countries.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"113 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140088525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.252
D. Lee, Y. Choi
It has been suggested that 5AR (5-alpha reductase) inhibitors may have negative effects on psychosexual activity, but there is still debate. We aimed to observe the effect of 5AR type 2 inhibition on brain tissue by using finasteride. 14 weeks old, eight male rats were assigned to each group (group 1 as the control group, group 2 as the finasteride group, and group 3 as the finasteride withdrawal group). Each rat was isolated and acclimatized in a single cage, then mated for 2 days. Rats in group 2 and 3 were administrated with finasteride for 4 weeks, then rats in group 2 were sacrificed whereas rats in group 3 were sacrificed 4 weeks thereafter. Before sacrifice, they were exposed to female bedding at least for 2 days. RT-PCR, western blot, and immunohistochemistry were performed for brain tissue evaluation where the target genes/proteins were 5AR (type 2) and c-Fos. Dihydrotestosterone (ng/dl) and dihydrotestosterone to testosterone ratio (%) plunged after 1 month administration of finasteride (group 2), and they were ameliorated after discontinuation of the drug (group 3) (Figure 1). These results were parallel to those from the western blot and immunohistochemistry (Figure 2 and 3). On the contraty, RT-PCR showed elevation of each gene (5AR and c-Fos) expression (Figure 2). Finasteride exerted an influence on brain tissue including hippocampus and ventromedial preoptic area via 5AR-2 inhibition, resulting in decrease of c-Fos protein activation. However, the negative impact of finasteride on rat brain in regard with c-Fos activation may fall away in a month cessation of the drug. No.
{"title":"(291) The Effect of Administration and Discontinuation of Finasteride in Male Rats","authors":"D. Lee, Y. Choi","doi":"10.1093/jsxmed/qdae002.252","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.252","url":null,"abstract":"\u0000 \u0000 \u0000 It has been suggested that 5AR (5-alpha reductase) inhibitors may have negative effects on psychosexual activity, but there is still debate.\u0000 \u0000 \u0000 \u0000 We aimed to observe the effect of 5AR type 2 inhibition on brain tissue by using finasteride.\u0000 \u0000 \u0000 \u0000 14 weeks old, eight male rats were assigned to each group (group 1 as the control group, group 2 as the finasteride group, and group 3 as the finasteride withdrawal group). Each rat was isolated and acclimatized in a single cage, then mated for 2 days. Rats in group 2 and 3 were administrated with finasteride for 4 weeks, then rats in group 2 were sacrificed whereas rats in group 3 were sacrificed 4 weeks thereafter. Before sacrifice, they were exposed to female bedding at least for 2 days. RT-PCR, western blot, and immunohistochemistry were performed for brain tissue evaluation where the target genes/proteins were 5AR (type 2) and c-Fos.\u0000 \u0000 \u0000 \u0000 Dihydrotestosterone (ng/dl) and dihydrotestosterone to testosterone ratio (%) plunged after 1 month administration of finasteride (group 2), and they were ameliorated after discontinuation of the drug (group 3) (Figure 1). These results were parallel to those from the western blot and immunohistochemistry (Figure 2 and 3). On the contraty, RT-PCR showed elevation of each gene (5AR and c-Fos) expression (Figure 2).\u0000 \u0000 \u0000 \u0000 Finasteride exerted an influence on brain tissue including hippocampus and ventromedial preoptic area via 5AR-2 inhibition, resulting in decrease of c-Fos protein activation. However, the negative impact of finasteride on rat brain in regard with c-Fos activation may fall away in a month cessation of the drug.\u0000 \u0000 \u0000 \u0000 No.\u0000 \u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"118 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.218
M. Hammad, H. Nakamura, J. Miller, B. Azad, F. Yafi
The COVID-19 pandemic has significantly impacted various aspects of society, including healthcare-seeking behaviors. Online search trends have become valuable indicators of public health concerns and interests. This study focuses on the search trends for penile implants to understand how these trends have changed in different metro/county income levels pre- and post-COVID-19. Data on Google search trends for penile implant procedures were collected for specific metropolitan areas before and after the COVID-19 pandemic. The metropolitan areas with the highest search intents were further analyzed. Average household income and per capita income, based off 2021 US Census Bureau, were calculated for the top five metropolitan hot spots (household income, per capita income before and after the pandemic) then visualized in a linear model. Between 2016 and 2023, pre- and post- COVID-19, the interest in penile implants has been steadily increasing on average in the US (figure 1). Within these interest groups, a handful of counties account for the most searches that result in the following surges, and are associated with specific socioeconomic backgrounds and events. Before COVID-19, the average household income of counties most interested in penile implants was $53,215.80 (39th percentile) and the per capita median income was $34,626.80 (37th percentile). Post-COVID-19, both of these averages decreased over time to $50, 945.17 (37th percentile) and $31, 435.17, respectively (34th percentile) (figure 2). This study demonstrates significant increases in Google search trends for penile implant procedures after the COVID-19 pandemic. Before the pandemic, higher-income regions demonstrated more interest in penile implant searches, potentially linked to affluence and investment in men’s health, compared to more interest in lower income regions post-pandemic. Any of the authors act as a consultant, employee or shareholder of an industry for: Advisory board and speaker for Coloplast; consultant for Cynosure; advisory board and speaker for Halozyme; intellectual property with Masimo; advisory board for Promescent; consultant for Sprout; advisory board for Xialla.
{"title":"(252) Has the COVID-19 Pandemic Impacted Penile Implant Public Interest in the US?","authors":"M. Hammad, H. Nakamura, J. Miller, B. Azad, F. Yafi","doi":"10.1093/jsxmed/qdae002.218","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.218","url":null,"abstract":"\u0000 \u0000 \u0000 The COVID-19 pandemic has significantly impacted various aspects of society, including healthcare-seeking behaviors. Online search trends have become valuable indicators of public health concerns and interests.\u0000 \u0000 \u0000 \u0000 This study focuses on the search trends for penile implants to understand how these trends have changed in different metro/county income levels pre- and post-COVID-19.\u0000 \u0000 \u0000 \u0000 Data on Google search trends for penile implant procedures were collected for specific metropolitan areas before and after the COVID-19 pandemic. The metropolitan areas with the highest search intents were further analyzed. Average household income and per capita income, based off 2021 US Census Bureau, were calculated for the top five metropolitan hot spots (household income, per capita income before and after the pandemic) then visualized in a linear model.\u0000 \u0000 \u0000 \u0000 Between 2016 and 2023, pre- and post- COVID-19, the interest in penile implants has been steadily increasing on average in the US (figure 1). Within these interest groups, a handful of counties account for the most searches that result in the following surges, and are associated with specific socioeconomic backgrounds and events. Before COVID-19, the average household income of counties most interested in penile implants was $53,215.80 (39th percentile) and the per capita median income was $34,626.80 (37th percentile). Post-COVID-19, both of these averages decreased over time to $50, 945.17 (37th percentile) and $31, 435.17, respectively (34th percentile) (figure 2).\u0000 \u0000 \u0000 \u0000 This study demonstrates significant increases in Google search trends for penile implant procedures after the COVID-19 pandemic. Before the pandemic, higher-income regions demonstrated more interest in penile implant searches, potentially linked to affluence and investment in men’s health, compared to more interest in lower income regions post-pandemic.\u0000 \u0000 \u0000 \u0000 Any of the authors act as a consultant, employee or shareholder of an industry for: Advisory board and speaker for Coloplast; consultant for Cynosure; advisory board and speaker for Halozyme; intellectual property with Masimo; advisory board for Promescent; consultant for Sprout; advisory board for Xialla.\u0000 \u0000 \u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"113 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.093
K. Khalaf Alla, R. Calopedos, J. Mehr, M. Mahdi, H. Slovacek, R. Wang
Medications, namely antiplatelets (AP) and anticoagulation (AC), are effective at avoiding fatal vascular complications and prolonging the lives of our patients. As such, more and more men seeking treatment for erectile dysfunction (ED) also take blood thinners. This is an interaction we must better understand to provide safe, individualized care to our patients and minimize peri-operative morbidity. Currently, there is no published information on whether differences exist in the escalation of treatment for patients with erectile dysfunction and on AC. A previous study has demonstrated no statistically significant difference in complications between AC and non-AC groups while on ICI, despite there being a higher rate of absolute bleeding events for AC patients. To compare outcomes and complication rates in patients undergoing IPP implantation following ICI therapy with or without concurrent anticoagulation. A retrospective observational study was undertaken. Electronic patient records from January to September 2021 were reviewed. Included patients were those who had either currently or previously utilized ICI therapy for ED treatment. ICI therapy surveys and Erectile Dysfunction Inventory for Treatment Satisfaction (EDITS) questionnaire were obtained. 85 patients met the inclusion criteria; 43 concurrently using AC during ICI therapy and 42 with no AC use. Patients who were unable to completely stop their AC medications a week before surgery due to cardiovascular concerns or recommendations, underwent bridging with a shorter half life and reversible AC. Extra measures taken during the IPP for such patients, including meticulous hemostasis, compression dressing and drain insertion. Additional data regarding IPP implantation as well as any complications or infections experienced following IPP surgery which were compared between the AC and no AC groups. Patient demographics, IPP implantation information and subsequent complication rates are listed below in Table 1. There was no statistically significant difference in the rate of patients who underwent IPP placement between the AC and no AC cohorts. Moreover, there was also no statistically significant difference in median time from date of initial ICI usage to time of IPP placement as well as median time from IPP placement to last follow-up. Among the 12 total patients who underwent IPP placement, none experienced any complications, including infection, mechanical failure, device removal or revision at any time point up to last follow-up (longest was 18 months). No statistically significant differences in EDITS score between both groups was observed. These preliminary findings, while requiring large-scale follow up, show that there is no statistically significant difference in rate of patients opting for IPP surgery following initiation of ICI therapy regardless of concomitant AC usage as well as the rate of complications following IPP implantation. Lastly, there is
抗血小板（AP）和抗凝（AC）药物可有效避免致命的血管并发症，延长患者的生命。因此，越来越多的男性在寻求勃起功能障碍（ED）治疗的同时也在服用血液稀释剂。我们必须更好地了解这种相互作用，以便为患者提供安全、个性化的护理，并将围手术期的发病率降至最低。目前，还没有关于勃起功能障碍患者与服用 AC 的患者在治疗升级方面是否存在差异的公开信息。之前的一项研究表明，尽管勃起功能障碍患者的绝对出血率较高，但在使用 ICI 期间，勃起功能障碍组和非勃起功能障碍组的并发症在统计学上没有明显差异。 目的：比较接受 ICI 治疗后同时接受或不接受抗凝治疗的 IPP 植入患者的预后和并发症发生率。 开展一项回顾性观察研究。研究人员查阅了 2021 年 1 月至 9 月的电子病历。研究对象包括目前或之前使用 ICI 治疗 ED 的患者。研究人员获得了 ICI 治疗调查表和勃起功能障碍治疗满意度量表 (EDITS) 问卷。85 名患者符合纳入标准；其中 43 人在 ICI 治疗期间同时使用 AC，42 人未使用 AC。因心血管问题或建议而无法在手术前一周完全停用 AC 药物的患者，将使用半衰期较短且可逆的 AC 进行桥接。在 IPP 期间对这类患者采取了额外措施，包括细致止血、加压包扎和插入引流管。有关 IPP 植入以及 IPP 术后并发症或感染的其他数据，在 AC 组和无 AC 组之间进行了比较。 表 1 列出了患者的人口统计学特征、IPP 植入信息和随后的并发症发生率。有 AC 和无 AC 组患者接受 IPP 植入术的比例在统计学上没有明显差异。此外，从首次使用 ICI 到置入 IPP 的中位时间以及从置入 IPP 到最后一次随访的中位时间也没有明显的统计学差异。在总共 12 名接受 IPP 置入术的患者中，截至最后一次随访（最长时间为 18 个月）的任何时间点，均未出现任何并发症，包括感染、机械故障、设备移除或翻修。两组患者的 EDITS 评分差异无统计学意义。 这些初步研究结果虽然还需要大规模的随访，但表明无论是否同时使用 AC，患者在开始 ICI 治疗后选择 IPP 手术的比例以及 IPP 植入后的并发症发生率在统计学上没有明显差异。最后，只要采取一切必要措施将出血并发症降至最低，在这一特定患者群中实施此类手术并无缺点。 不
{"title":"(102) A Preliminary Analysis of Outcomes and Complication Rates for Patients Undergoing Inflatable Penile Prosthesis Implantation Following Intracavernosal Injection Therapy With or Without Concurrent Anticoagulation","authors":"K. Khalaf Alla, R. Calopedos, J. Mehr, M. Mahdi, H. Slovacek, R. Wang","doi":"10.1093/jsxmed/qdae002.093","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.093","url":null,"abstract":"\u0000 \u0000 \u0000 Medications, namely antiplatelets (AP) and anticoagulation (AC), are effective at avoiding fatal vascular complications and prolonging the lives of our patients. As such, more and more men seeking treatment for erectile dysfunction (ED) also take blood thinners. This is an interaction we must better understand to provide safe, individualized care to our patients and minimize peri-operative morbidity. Currently, there is no published information on whether differences exist in the escalation of treatment for patients with erectile dysfunction and on AC. A previous study has demonstrated no statistically significant difference in complications between AC and non-AC groups while on ICI, despite there being a higher rate of absolute bleeding events for AC patients.\u0000 \u0000 \u0000 \u0000 To compare outcomes and complication rates in patients undergoing IPP implantation following ICI therapy with or without concurrent anticoagulation.\u0000 \u0000 \u0000 \u0000 A retrospective observational study was undertaken. Electronic patient records from January to September 2021 were reviewed. Included patients were those who had either currently or previously utilized ICI therapy for ED treatment. ICI therapy surveys and Erectile Dysfunction Inventory for Treatment Satisfaction (EDITS) questionnaire were obtained. 85 patients met the inclusion criteria; 43 concurrently using AC during ICI therapy and 42 with no AC use. Patients who were unable to completely stop their AC medications a week before surgery due to cardiovascular concerns or recommendations, underwent bridging with a shorter half life and reversible AC. Extra measures taken during the IPP for such patients, including meticulous hemostasis, compression dressing and drain insertion. Additional data regarding IPP implantation as well as any complications or infections experienced following IPP surgery which were compared between the AC and no AC groups.\u0000 \u0000 \u0000 \u0000 Patient demographics, IPP implantation information and subsequent complication rates are listed below in Table 1. There was no statistically significant difference in the rate of patients who underwent IPP placement between the AC and no AC cohorts. Moreover, there was also no statistically significant difference in median time from date of initial ICI usage to time of IPP placement as well as median time from IPP placement to last follow-up. Among the 12 total patients who underwent IPP placement, none experienced any complications, including infection, mechanical failure, device removal or revision at any time point up to last follow-up (longest was 18 months). No statistically significant differences in EDITS score between both groups was observed.\u0000 \u0000 \u0000 \u0000 These preliminary findings, while requiring large-scale follow up, show that there is no statistically significant difference in rate of patients opting for IPP surgery following initiation of ICI therapy regardless of concomitant AC usage as well as the rate of complications following IPP implantation. Lastly, there is","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":" 689","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.001
K. Park, G. Kim, M. Lee, H. S. Lee, G. Jeong
Cross-sex hormones in female-to-male (FtM) transgender individuals play a crucial role in brain plasticity. Brain activity associated with sexual arousal in FtM transgenders receiving cross-sex hormones is poorly understood. This study aimed to compare brain activation patterns associated with sexual arousal between FtM transgenders and premenopausal women using a 3.0 Tesla functional magnetic resonance imaging (fMRI). This study included 13 FtM transgenders (mean age: 43.2±6.4 years) and 13 premenopausal women (mean age: 41.5 ± 8.3 years). The FtM transgender individuals, who have had sex-reassignment surgery, received testosterone supplementary therapy. Sexual orientation was evaluated using the Kinsey sexuality rating scale (0 = exclusively heterosexual; 6 = exclusively homosexual). Serum sex hormones were measured, including free testosterone (free-T), estradiol (E2), follicle-stimulating, and luteinizing hormones. Visual sexual stimulation began with a 30-s cross fixation (rest condition), followed by a 30-s natural documentary (neutral condition), 540-s erotic video (sexual activation condition), then a 30-s cross fixation (rest condition). The fMRI data were post-processed using SPM8 software. The average rating of the Kinsey scale in the FtM transgenders was 5.6 ± 0.5, indicating their sexual orientation falls within the category of homosexual. The FtM transgenders showed significant increases in the free-T levels (18.8±18.9 pg/mL vs. 0.4±0.4 pg/mL, p < 0.001) and significant decreases in the E2 levels (45.4±32.0 pg/mL vs. 279.2±247.3 pg/mL, p = 0.001) compared with premenopausal women. The brain areas with significantly higher activities during visual sexual stimuli in the FtM transgenders compared with premenopausal women included the superior parietal lobule, middle occipital gyrus, and superior frontal gyrus (p < 0.001). This study illustrates the specific brain activation patterns associated with sexual arousal in female-to-male (FtM) transgenders. These findings could contribute to our understanding of the neural mechanisms associated with sexual arousal in relation to the levels of sexual hormones in FtM transgenders. This research was supported by grants from the National Research Foundation funded by the government (MSIT; 2022R1A2C2007809, 2021R1C1C2011748). No.
{"title":"(001) Brain Activation Patterns Associated with Visually Evoked Sexual Arousal in Female-To-Male Transgender Individuals","authors":"K. Park, G. Kim, M. Lee, H. S. Lee, G. Jeong","doi":"10.1093/jsxmed/qdae002.001","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.001","url":null,"abstract":"\u0000 \u0000 \u0000 Cross-sex hormones in female-to-male (FtM) transgender individuals play a crucial role in brain plasticity. Brain activity associated with sexual arousal in FtM transgenders receiving cross-sex hormones is poorly understood.\u0000 \u0000 \u0000 \u0000 This study aimed to compare brain activation patterns associated with sexual arousal between FtM transgenders and premenopausal women using a 3.0 Tesla functional magnetic resonance imaging (fMRI).\u0000 \u0000 \u0000 \u0000 This study included 13 FtM transgenders (mean age: 43.2±6.4 years) and 13 premenopausal women (mean age: 41.5 ± 8.3 years). The FtM transgender individuals, who have had sex-reassignment surgery, received testosterone supplementary therapy. Sexual orientation was evaluated using the Kinsey sexuality rating scale (0 = exclusively heterosexual; 6 = exclusively homosexual). Serum sex hormones were measured, including free testosterone (free-T), estradiol (E2), follicle-stimulating, and luteinizing hormones. Visual sexual stimulation began with a 30-s cross fixation (rest condition), followed by a 30-s natural documentary (neutral condition), 540-s erotic video (sexual activation condition), then a 30-s cross fixation (rest condition). The fMRI data were post-processed using SPM8 software.\u0000 \u0000 \u0000 \u0000 The average rating of the Kinsey scale in the FtM transgenders was 5.6 ± 0.5, indicating their sexual orientation falls within the category of homosexual. The FtM transgenders showed significant increases in the free-T levels (18.8±18.9 pg/mL vs. 0.4±0.4 pg/mL, p < 0.001) and significant decreases in the E2 levels (45.4±32.0 pg/mL vs. 279.2±247.3 pg/mL, p = 0.001) compared with premenopausal women. The brain areas with significantly higher activities during visual sexual stimuli in the FtM transgenders compared with premenopausal women included the superior parietal lobule, middle occipital gyrus, and superior frontal gyrus (p < 0.001).\u0000 \u0000 \u0000 \u0000 This study illustrates the specific brain activation patterns associated with sexual arousal in female-to-male (FtM) transgenders. These findings could contribute to our understanding of the neural mechanisms associated with sexual arousal in relation to the levels of sexual hormones in FtM transgenders. This research was supported by grants from the National Research Foundation funded by the government (MSIT; 2022R1A2C2007809, 2021R1C1C2011748).\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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