Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.017
K. Khalaf Alla, M. Mahdi, J. Mehr, O. Westney, R. Wang
Artificial urinary sphincter (AUS) and bulbourethral male sling are used frequently in the management of post prostatectomy urinary incontinence (UI) in men. Some surgeons used to combine an inflatable Penile Prosthesis (IPP) procedure at the same setting to treat concurrent erectile dysfunction (ED). Recent clinical trials have aimed to determine the comparative effectiveness between the male sling and the artificial urinary sphincter (AUS) in men with urodynamic stress urinary incontinence (SUI) after prostate surgery, focusing on non-inferiority. We aim to compare continence control and complications rates in patients who underwent bulbourethral slings or AUS during IPP surgery via perineal approach. A retrospective chart review was done in a large tertiary center. Post prostatectomy patients who underwent perineal dual implantation IPP and AUS or bulbourethral sling for ED and UI purposes, between 2014 and 2022 were included. Clinical data, patients’ demographics were retrieved. Post-operative outcomes with regards to IPP complication rates, revision rates for IPP/ AUS / Male sling, and continence control at 6 weeks, 6 months and 1 year were collected and included in the analysis. Continence control rates were assessed by the number of pads used per day on subsequent follow up visits for both groups. A total of 32 patients met the inclusion criteria. 16 Patients underwent synchronous IPP and AUS insertion, whereas another 16 patients underwent IPP with bulbourethral sling procedure. Patient demographics, median follow up & complication rates are summarized below in Table 1. In both groups the procedure was done through a perineal approach. There was no significant difference in baseline data among groups. Complication rates between AUS devices and bulbourethral slings showed no statistically significant differences (12.5% vs 6.25% p= 0.22 respectively). Infection rates and need for revision also did not show any statistically significant differences. With regards to post-operative continence rates, both groups had comparable outcome with no significant differences (P = 0.81). Upon the 6 months follow up visit, the AUS group, 56% were pad free, 19% used 1 pad per day, 19% used 2 pads per day, and 6% used 3 pads or more per day, while in the sling group, 50% were pad free, 25% used 1 pad per day, 19% used 2 pads per day, and 6% used 3 pads or more per day. Patients were followed for a total of 1 year after the surgery. The combined insertion of IPP with either AUS or sling procedures has comparable outcomes with regards to continence rate and device- related complications. Each incontinence surgery should be chosen according to surgeon experience and specific patient indications. Further prospective studies on a larger sample of patients with longer follow up period are needed to solidify these findings and will guide patient's decision and preference for incontinence surgeries along with IPP once indicated.
{"title":"(017) Comparing Complication Rates and Continence Control in Concurrent Dual Implantation of Inflatable Penile Prosthesis/Artificial Urinary Sphincter vs. Inflatable Penile Prosthesis/Male Sling: An Updated Comparative Pilot Study","authors":"K. Khalaf Alla, M. Mahdi, J. Mehr, O. Westney, R. Wang","doi":"10.1093/jsxmed/qdae002.017","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.017","url":null,"abstract":"\u0000 \u0000 \u0000 Artificial urinary sphincter (AUS) and bulbourethral male sling are used frequently in the management of post prostatectomy urinary incontinence (UI) in men. Some surgeons used to combine an inflatable Penile Prosthesis (IPP) procedure at the same setting to treat concurrent erectile dysfunction (ED). Recent clinical trials have aimed to determine the comparative effectiveness between the male sling and the artificial urinary sphincter (AUS) in men with urodynamic stress urinary incontinence (SUI) after prostate surgery, focusing on non-inferiority.\u0000 \u0000 \u0000 \u0000 We aim to compare continence control and complications rates in patients who underwent bulbourethral slings or AUS during IPP surgery via perineal approach.\u0000 \u0000 \u0000 \u0000 A retrospective chart review was done in a large tertiary center. Post prostatectomy patients who underwent perineal dual implantation IPP and AUS or bulbourethral sling for ED and UI purposes, between 2014 and 2022 were included. Clinical data, patients’ demographics were retrieved. Post-operative outcomes with regards to IPP complication rates, revision rates for IPP/ AUS / Male sling, and continence control at 6 weeks, 6 months and 1 year were collected and included in the analysis. Continence control rates were assessed by the number of pads used per day on subsequent follow up visits for both groups.\u0000 \u0000 \u0000 \u0000 A total of 32 patients met the inclusion criteria. 16 Patients underwent synchronous IPP and AUS insertion, whereas another 16 patients underwent IPP with bulbourethral sling procedure. Patient demographics, median follow up & complication rates are summarized below in Table 1. In both groups the procedure was done through a perineal approach. There was no significant difference in baseline data among groups. Complication rates between AUS devices and bulbourethral slings showed no statistically significant differences (12.5% vs 6.25% p= 0.22 respectively). Infection rates and need for revision also did not show any statistically significant differences. With regards to post-operative continence rates, both groups had comparable outcome with no significant differences (P = 0.81). Upon the 6 months follow up visit, the AUS group, 56% were pad free, 19% used 1 pad per day, 19% used 2 pads per day, and 6% used 3 pads or more per day, while in the sling group, 50% were pad free, 25% used 1 pad per day, 19% used 2 pads per day, and 6% used 3 pads or more per day. Patients were followed for a total of 1 year after the surgery.\u0000 \u0000 \u0000 \u0000 The combined insertion of IPP with either AUS or sling procedures has comparable outcomes with regards to continence rate and device- related complications. Each incontinence surgery should be chosen according to surgeon experience and specific patient indications. Further prospective studies on a larger sample of patients with longer follow up period are needed to solidify these findings and will guide patient's decision and preference for incontinence surgeries along with IPP once indicated.\u0000 \u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140269363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.007
G. Seijas, S. G. Comerma Steffensen, A. Gomez Del Val, G. Wegener, U. Simonsen
Female sexual behavior animal translation data do not translate to acute results and neither current synchronization invasive models (ovariectomy+Estrogen “E2”+Progesterone “P4”) guarantee hormonal physiological values. Therefore, our study investigated the effect of non-invasive oestrus synchronization on sexual behavior. Methods: Twelve week old Sprague Dawley intact rats were synchronized and randomly divided into three groups each of n=8-10. Each group received a dose of prostaglandin F2α “PGF2α” (75, 125 and 250 μg) at days 0 and 3, and 1 mg of progesterone at day four. Vaginal cytology was performed to determine the point of the cycle and the animals underwent an incentive test. To investigate the sexual behavior, the synchronized female rats were paired with trained male rats, and behavior recorded. The videos were quantified by trained operators. Sexual behavior was quantified as paracopulatory (hops, darts, ear wiggling, sniffing from male and from female) or copulatory (male mounting female, thrusting from male, intromission, ejaculation, female for sniffing position, lordosis, orgasm, female mounting on male, female rotation in her axis and female licking itself), E2 and Follicle Stimulating hormone (FSH) in plasma and E2 in vaginal fluid were quantified by immune assay. Based on the vaginal cytology, the proportion of animals in proestrus (p), estrus (e) or metestrus (m) was calculated with values of 0.5 (p), 0.25 (e) and 0.25 (m) for the group which received 0.75 μg PGF2α; 0.4 (p), and 0.6 (e) for the group which received 0.125 μg PGF2α; 0.2 (p), 0.5 (e), and 0.3 (m) for the group which received 250 μg PGF2α. The numbers of hops was higher in the proestrus compared to the metestrus, and of mounts higher in the estrus compared to the metestrus phase. The sexual encounter profile and E2 levels were unchanged with the different PGF2α doses, but in the high-dose group no hops were observed. The levels of sexual behavior was comparable to previous studies of hormone substituted ovariectomized rats, but E2 and FSH plasma levels were in a physiological range. In summary, the non-invasive synchronization protocol could substitute the state-of-the-art used ovariectomized+hormone (E2) model. Our findings suggest the largest part of rats were synchronized in the oestrus phase with 125 μg PGF2α. but the 250 μg had also a positive profile. Any of the authors act as a consultant, employee or shareholder of an industry for: Initiator Pharma A/S.
{"title":"(007) Impact of Non-Invasive Oestrus Synchronization on Sexual Behavior in Intact Sprague Dawley Rats","authors":"G. Seijas, S. G. Comerma Steffensen, A. Gomez Del Val, G. Wegener, U. Simonsen","doi":"10.1093/jsxmed/qdae002.007","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.007","url":null,"abstract":"\u0000 \u0000 \u0000 Female sexual behavior animal translation data do not translate to acute results and neither current synchronization invasive models (ovariectomy+Estrogen “E2”+Progesterone “P4”) guarantee hormonal physiological values.\u0000 \u0000 \u0000 \u0000 Therefore, our study investigated the effect of non-invasive oestrus synchronization on sexual behavior.\u0000 \u0000 \u0000 \u0000 Methods: Twelve week old Sprague Dawley intact rats were synchronized and randomly divided into three groups each of n=8-10. Each group received a dose of prostaglandin F2α “PGF2α” (75, 125 and 250 μg) at days 0 and 3, and 1 mg of progesterone at day four. Vaginal cytology was performed to determine the point of the cycle and the animals underwent an incentive test. To investigate the sexual behavior, the synchronized female rats were paired with trained male rats, and behavior recorded. The videos were quantified by trained operators. Sexual behavior was quantified as paracopulatory (hops, darts, ear wiggling, sniffing from male and from female) or copulatory (male mounting female, thrusting from male, intromission, ejaculation, female for sniffing position, lordosis, orgasm, female mounting on male, female rotation in her axis and female licking itself), E2 and Follicle Stimulating hormone (FSH) in plasma and E2 in vaginal fluid were quantified by immune assay.\u0000 \u0000 \u0000 \u0000 Based on the vaginal cytology, the proportion of animals in proestrus (p), estrus (e) or metestrus (m) was calculated with values of 0.5 (p), 0.25 (e) and 0.25 (m) for the group which received 0.75 μg PGF2α; 0.4 (p), and 0.6 (e) for the group which received 0.125 μg PGF2α; 0.2 (p), 0.5 (e), and 0.3 (m) for the group which received 250 μg PGF2α. The numbers of hops was higher in the proestrus compared to the metestrus, and of mounts higher in the estrus compared to the metestrus phase. The sexual encounter profile and E2 levels were unchanged with the different PGF2α doses, but in the high-dose group no hops were observed. The levels of sexual behavior was comparable to previous studies of hormone substituted ovariectomized rats, but E2 and FSH plasma levels were in a physiological range.\u0000 \u0000 \u0000 \u0000 In summary, the non-invasive synchronization protocol could substitute the state-of-the-art used ovariectomized+hormone (E2) model. Our findings suggest the largest part of rats were synchronized in the oestrus phase with 125 μg PGF2α. but the 250 μg had also a positive profile.\u0000 \u0000 \u0000 \u0000 Any of the authors act as a consultant, employee or shareholder of an industry for: Initiator Pharma A/S.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.048
O. Kaabia, K. Dimassi
Assuming that the Obstetrician and Gynecologist (ObGyn) is the natural and first interlocutor for sexual questions in women, particular attention should be paid to their specific training in sexual health and clinical sexology. However, it turns out that the latter is neglected with little attention given to the development or implementation of specific curricular programs within the gynecologists’ residency programs. This study aims to: - Identify and analyze the specific needs of the ObGyn residents in terms of education and training in Sexual Health and Clinical Sexology. - Discuss the methods of integrating a specific sexology training into their residency program to be adapted to the needs thus identified. It is a knowledge, attitudes, and practices cross-sectional online study that took place over 5 weeks starting May 1st, 2021. All the ObGyn residents registered at the National College of Gynecology and Obstetrics were contacted through the College’s social media groups. The online questionnaire was a 9-item Google form elaborated in concertation with the Frequency, Gravity Problem (FGP) grid leading to 33 questions. With a response rate of 34 %, 94 residents participated in the survey. The participants were representative of the local population of ObGyn residents with an equal proportion of participants from the 5 years of the program. According to 69% of the participants, complaints or sexual disorders are rarely encountered during the ObGyn residency program courses. This finding was not correlated with the participants' residency level (R= 0.258, p> 0.05). The most frequently encountered sexual disorders during the clinical consultations were sexual disorders with pain (44.68%) and in particular vaginismus (75%). Regardless of the frequency of the disorders, the difficulties reported were primarily in the domain of knowledge (67.5%); then in the domain of know-how or practices (68%), and often in the domain of interpersonal skills (42.2%). Following the application of the rating system of the FGP grid, the main problems identified concerned sexual disorders with pain, in particular, vaginismus and then a decrease in female desire. Following the analysis of these results and a review of the literature, we were able to propose the outline of a project to implement basic academic education and training in clinical sexology for the ObGyn residents. No.
{"title":"(052) Sexual Health and Clinical Sexology Specific Training Needs of Residents in Gynecology and Obstetrics","authors":"O. Kaabia, K. Dimassi","doi":"10.1093/jsxmed/qdae002.048","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.048","url":null,"abstract":"\u0000 \u0000 \u0000 Assuming that the Obstetrician and Gynecologist (ObGyn) is the natural and first interlocutor for sexual questions in women, particular attention should be paid to their specific training in sexual health and clinical sexology. However, it turns out that the latter is neglected with little attention given to the development or implementation of specific curricular programs within the gynecologists’ residency programs.\u0000 \u0000 \u0000 \u0000 This study aims to: - Identify and analyze the specific needs of the ObGyn residents in terms of education and training in Sexual Health and Clinical Sexology. - Discuss the methods of integrating a specific sexology training into their residency program to be adapted to the needs thus identified.\u0000 \u0000 \u0000 \u0000 It is a knowledge, attitudes, and practices cross-sectional online study that took place over 5 weeks starting May 1st, 2021. All the ObGyn residents registered at the National College of Gynecology and Obstetrics were contacted through the College’s social media groups. The online questionnaire was a 9-item Google form elaborated in concertation with the Frequency, Gravity Problem (FGP) grid leading to 33 questions.\u0000 \u0000 \u0000 \u0000 With a response rate of 34 %, 94 residents participated in the survey. The participants were representative of the local population of ObGyn residents with an equal proportion of participants from the 5 years of the program. According to 69% of the participants, complaints or sexual disorders are rarely encountered during the ObGyn residency program courses. This finding was not correlated with the participants' residency level (R= 0.258, p> 0.05). The most frequently encountered sexual disorders during the clinical consultations were sexual disorders with pain (44.68%) and in particular vaginismus (75%). Regardless of the frequency of the disorders, the difficulties reported were primarily in the domain of knowledge (67.5%); then in the domain of know-how or practices (68%), and often in the domain of interpersonal skills (42.2%). Following the application of the rating system of the FGP grid, the main problems identified concerned sexual disorders with pain, in particular, vaginismus and then a decrease in female desire.\u0000 \u0000 \u0000 \u0000 Following the analysis of these results and a review of the literature, we were able to propose the outline of a project to implement basic academic education and training in clinical sexology for the ObGyn residents.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.122
A. R. Cintra, B. L. Linhares, E. L. Da Rocha, M. M. F. Monteiro, K. M. Da Trindade, M. S. R. Lopes, J. Linhares-Filho, M. J. Da Silva, H. T. Palmeira, J. Bessa Jr, E. P. Miranda, R. Reges
Androgen deprivation therapy (ADT) is considered one of the mainstays in the treatment of prostate cancer. ADT slows cancer progression, alleviates cancer-related symptoms, and is associated with survival gains. Despite these proven benefits, this treatment is related to several side effects, such as increased cardiovascular risk, changes in body composition and various metabolic changes. Although the well-established association between circulating testosterone level and endothelial integrity, the direct effects of ADT on endothelial function remain controversial. This study aimed to investigate the impact of ADT on endothelial function, through the analysis of vascular parameters of the brachial artery and measurement of serum inflammatory markers. It was also our aim to evaluate the early impact of ADT on body composition and metabolic parameters. We prospectively evaluated men with moderate to high-risk prostate cancer treated with ADT from January to December 2022 at our institution. Smokers and those who quit smoking less than five years ago, decompensated diabetics (glycated hemoglobin > 9%) and those who had already had a cardiovascular event were excluded. High-resolution B-mode ultrasound was used to assess vascular diameter and endothelium-dependent flow-mediated vasodilation (FMD) of the brachial artery. Our metabolic and inflammatory profile included measurement of serum total cholesterol and fractions, triglycerides, fasting glucose, glycated hemoglobin, basal insulin, C-reactive protein and assessment of body fat distribution through bioelectrical impedance. Subjects were evaluated at baseline and 3 months after starting ADT with goserelin acetate 10.80 mg. A total of 32 men were included. The mean age was 69 years and the prevalence of diabetes was 31.25%. FMD demonstrated a worsening trend after ADT, which did not reach statistical significance after 3 months (mean 3.39 ± 6.83 vs 1.16 ± 7.65; p = 0.14) (figure 1). Baseline brachial artery diameter also showed a tendency to worsen with ADT compared to baseline (0.44 ± 0.06 vs 0.42 ± 0.06; p = 0.06). With regard to the metabolic profile, ADT significantly increased insulin resistance: fasting glucose (mean 104.10 ± 18.96 vs 110.60 ± 25.29; p = 0.01), fasting insulin levels (mean 13.05 ± 8.76 vs 16.82 ± 11.36; p = 0.003), glycated hemoglobin (mean 5.89% ± 0.46 vs 6.15% ± 0.67; p = 0.008) and homeostatic model assessment insulin resistance (mean 3.47 ± 2.55 vs 5.05 ± 4.50; p = 0.005) increased significantly after 3 months. Triglycerides concentrations (mean 142.30 ± 69.66 vs 165.50 ± 93.04; p = 0.03) were higher after 3 months of ADT. Abdominal circumference (mean 98.66 ± 10.16 vs 99.76 ± 9.39; p = 0.02) and body mass index (mean 27.46 ± 4.06 vs 27.76 ± 3.89; p = 0.02) also increased after ADT. Although not statistically significant, the present study demonstrated a trend towards a decrease in brachial artery FMD. We also observed an important and su
{"title":"(134) Early Impact of Androgen Deprivation Therapy on Endothelial Function and Metabolic Parameters in Prostate Cancer Patients: A Prospective Study","authors":"A. R. Cintra, B. L. Linhares, E. L. Da Rocha, M. M. F. Monteiro, K. M. Da Trindade, M. S. R. Lopes, J. Linhares-Filho, M. J. Da Silva, H. T. Palmeira, J. Bessa Jr, E. P. Miranda, R. Reges","doi":"10.1093/jsxmed/qdae002.122","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.122","url":null,"abstract":"\u0000 \u0000 \u0000 Androgen deprivation therapy (ADT) is considered one of the mainstays in the treatment of prostate cancer. ADT slows cancer progression, alleviates cancer-related symptoms, and is associated with survival gains. Despite these proven benefits, this treatment is related to several side effects, such as increased cardiovascular risk, changes in body composition and various metabolic changes. Although the well-established association between circulating testosterone level and endothelial integrity, the direct effects of ADT on endothelial function remain controversial.\u0000 \u0000 \u0000 \u0000 This study aimed to investigate the impact of ADT on endothelial function, through the analysis of vascular parameters of the brachial artery and measurement of serum inflammatory markers. It was also our aim to evaluate the early impact of ADT on body composition and metabolic parameters.\u0000 \u0000 \u0000 \u0000 We prospectively evaluated men with moderate to high-risk prostate cancer treated with ADT from January to December 2022 at our institution. Smokers and those who quit smoking less than five years ago, decompensated diabetics (glycated hemoglobin > 9%) and those who had already had a cardiovascular event were excluded. High-resolution B-mode ultrasound was used to assess vascular diameter and endothelium-dependent flow-mediated vasodilation (FMD) of the brachial artery. Our metabolic and inflammatory profile included measurement of serum total cholesterol and fractions, triglycerides, fasting glucose, glycated hemoglobin, basal insulin, C-reactive protein and assessment of body fat distribution through bioelectrical impedance. Subjects were evaluated at baseline and 3 months after starting ADT with goserelin acetate 10.80 mg.\u0000 \u0000 \u0000 \u0000 A total of 32 men were included. The mean age was 69 years and the prevalence of diabetes was 31.25%. FMD demonstrated a worsening trend after ADT, which did not reach statistical significance after 3 months (mean 3.39 ± 6.83 vs 1.16 ± 7.65; p = 0.14) (figure 1). Baseline brachial artery diameter also showed a tendency to worsen with ADT compared to baseline (0.44 ± 0.06 vs 0.42 ± 0.06; p = 0.06). With regard to the metabolic profile, ADT significantly increased insulin resistance: fasting glucose (mean 104.10 ± 18.96 vs 110.60 ± 25.29; p = 0.01), fasting insulin levels (mean 13.05 ± 8.76 vs 16.82 ± 11.36; p = 0.003), glycated hemoglobin (mean 5.89% ± 0.46 vs 6.15% ± 0.67; p = 0.008) and homeostatic model assessment insulin resistance (mean 3.47 ± 2.55 vs 5.05 ± 4.50; p = 0.005) increased significantly after 3 months. Triglycerides concentrations (mean 142.30 ± 69.66 vs 165.50 ± 93.04; p = 0.03) were higher after 3 months of ADT. Abdominal circumference (mean 98.66 ± 10.16 vs 99.76 ± 9.39; p = 0.02) and body mass index (mean 27.46 ± 4.06 vs 27.76 ± 3.89; p = 0.02) also increased after ADT.\u0000 \u0000 \u0000 \u0000 Although not statistically significant, the present study demonstrated a trend towards a decrease in brachial artery FMD. We also observed an important and su","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"507 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.113
K. Drasa, E. Bylykbashi
In healthy men, the average duration of sexual intercourse ranges from nine to ten minutes. However, duration of erection has been shown to be shorter in men with Erectile Dysfunction (ED) and even shorter for men with ED plus associated underlying conditions. Furthermore, duration of Penis erection is most important for sexual couple. The aim of this study was to assess two herbal supplements: HILTI gold (Hg) vs Epimedyumlu Macun (EM) efficacy in terms of duration of erection and (i) Its correlation with other efficacy end points and male and female sexual quality of life (QoL) and (ii) Its impact on intercourse duration. A double-blind, controlled trial randomized men (18–65 years of age) with ED for more than six months, to receive fixed-dose either Hg, 1 capsule or EM, 1 tea spoon (60 minutes prior intercourse) for 12 weeks in 52 patients with ED, after four-week without medication. Primary efficacy end points were stopwatch-assessed duration of erection (min) at any attempt and when leading to successful intercourse, and the erectile function domain of the International Index of Erectile Function (EF-IIEF) score was assessed at week 12/ last observation carried forward (LOCF). Secondary end points were Sexual Encounter Profile question three (SEP3) response rate and male sexual QoL. End points in participating women were stopwatch-assessed duration of intercourse and sexual QoL. 52 men included. 42% had moderate ED. 58% had severe ED at baseline. At week 12 / LOCF, patients taking Hg had longer duration of erections vs EM group (least square mean ± standard error 10.3±0.8 minutes vs. 7.7±0.7 minutes, and 10.3±0.8 vs. 7.8 ±1.0 minutes, respectively), and significant increases in EF-IIEF scores, the SEP3 response, and all sexual QoL items. An increased duration of intercourse was also observed. Female sexual QoL improved significantly. Both duration end points strongly correlated with EF-IIEF scores, and the three end points correlated well with SEP3 response. Correlation was good with sexual QoL scores in men and women and with duration of intercourse, with difference between groups only for duration end points. Safety was better in Hg than in EM group. The results indicate that duration of erection represents a novel efficacy measures for evaluating those herbal supplements (HS), and could be used as a predictor or efficacy measure of sexual performance in couples affected by ED. With regard to the method of measuring duration, stopwatch method was shown to be reliable and capable of complementing traditional self-assessment efficacy methods for evaluating the efficacy of HS. Hg is the best to significantly improve: Duration of erection in men with ED and Sexual QoL, in both members of a couple affected by ED than EM Absolutely, Hg and EM: Increase duration of erection; Improve sexual pleasure. And, thereby improving the sexual QoL of the COUPLE. And, most important is that sexual couples don’t risk to be un
健康男性的平均性交时间为九到十分钟。然而，事实证明，患有勃起功能障碍（ED）的男性勃起持续时间较短，而患有 ED 和相关潜在疾病的男性勃起持续时间更短。此外，阴茎勃起的持续时间对于性伴侣来说是最重要的。 本研究旨在评估两种草药补充剂：HILTI gold (Hg) 与 Epimedyumlu Macun (EM) 在阴茎勃起持续时间方面的疗效，以及 (i) 与其他疗效终点、男性和女性性生活质量 (QoL) 的相关性和 (ii) 对性交持续时间的影响。 一项双盲对照试验将患有 ED 超过 6 个月的男性（18-65 岁）随机分为两种剂量，一种是固定剂量的 Hg（1 粒胶囊），另一种是固定剂量的 EM（1 茶匙，性交前 60 分钟），52 名 ED 患者在未服药 4 周后接受了为期 12 周的试验。主要疗效终点为秒表评估的任何尝试和成功性交时的勃起持续时间（分钟），以及在第12周/最后一次观察结转（LOCF）时评估的国际勃起功能指数（EF-IIEF）勃起功能领域得分。次要终点是性接触档案问题三（SEP3）应答率和男性性生活质量。参与女性的终点为秒表评估的性交持续时间和性生活质量。 共纳入 52 名男性。42%患有中度ED。58%的基线值为重度 ED。在第 12 周/LOCF，服用 Hg 的患者与 EM 组相比，勃起持续时间更长（最小平方均值 ± 标准误差分别为 10.3±0.8 分钟 vs. 7.7±0.7 分钟和 10.3±0.8 分钟 vs. 7.8 ±1.0 分钟），EF-IIEF 评分、SEP3 反应和所有性生活 QoL 项目均显著增加。此外，还观察到性交持续时间延长。女性的性生活质量明显提高。两个持续时间终点都与 EF-IIEF 分数密切相关，三个终点都与 SEP3 反应密切相关。男性和女性的性生活质量评分与性交持续时间的相关性良好，仅在持续时间终点上存在组间差异。Hg 组的安全性优于 EM 组。 研究结果表明，勃起持续时间是评估草药补充剂（HS）的一种新型疗效指标，可用作受 ED 影响的夫妇性功能的预测指标或疗效指标。在测量持续时间的方法方面，秒表法被证明是可靠的，能够补充传统的自我评估疗效方法，用于评价中草药补充剂的疗效。Hg的改善效果最好：与 EM 绝对相比，Hg 和 EM 能够：延长勃起时间；提高性快感。从而提高夫妻双方的性生活质量。最重要的是，性伴侣不会有不忠的风险。 不
{"title":"(125) Efficacy of Hilti Gold vs. Epimedyumlu Macun in Duration of Erection and Its Correlation with Partners ´Sexual Quality of Life","authors":"K. Drasa, E. Bylykbashi","doi":"10.1093/jsxmed/qdae002.113","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.113","url":null,"abstract":"\u0000 \u0000 \u0000 In healthy men, the average duration of sexual intercourse ranges from nine to ten minutes. However, duration of erection has been shown to be shorter in men with Erectile Dysfunction (ED) and even shorter for men with ED plus associated underlying conditions. Furthermore, duration of Penis erection is most important for sexual couple.\u0000 \u0000 \u0000 \u0000 The aim of this study was to assess two herbal supplements: HILTI gold (Hg) vs Epimedyumlu Macun (EM) efficacy in terms of duration of erection and (i) Its correlation with other efficacy end points and male and female sexual quality of life (QoL) and (ii) Its impact on intercourse duration.\u0000 \u0000 \u0000 \u0000 A double-blind, controlled trial randomized men (18–65 years of age) with ED for more than six months, to receive fixed-dose either Hg, 1 capsule or EM, 1 tea spoon (60 minutes prior intercourse) for 12 weeks in 52 patients with ED, after four-week without medication. Primary efficacy end points were stopwatch-assessed duration of erection (min) at any attempt and when leading to successful intercourse, and the erectile function domain of the International Index of Erectile Function (EF-IIEF) score was assessed at week 12/ last observation carried forward (LOCF). Secondary end points were Sexual Encounter Profile question three (SEP3) response rate and male sexual QoL. End points in participating women were stopwatch-assessed duration of intercourse and sexual QoL.\u0000 \u0000 \u0000 \u0000 52 men included. 42% had moderate ED. 58% had severe ED at baseline. At week 12 / LOCF, patients taking Hg had longer duration of erections vs EM group (least square mean ± standard error 10.3±0.8 minutes vs. 7.7±0.7 minutes, and 10.3±0.8 vs. 7.8 ±1.0 minutes, respectively), and significant increases in EF-IIEF scores, the SEP3 response, and all sexual QoL items. An increased duration of intercourse was also observed. Female sexual QoL improved significantly. Both duration end points strongly correlated with EF-IIEF scores, and the three end points correlated well with SEP3 response. Correlation was good with sexual QoL scores in men and women and with duration of intercourse, with difference between groups only for duration end points. Safety was better in Hg than in EM group.\u0000 \u0000 \u0000 \u0000 The results indicate that duration of erection represents a novel efficacy measures for evaluating those herbal supplements (HS), and could be used as a predictor or efficacy measure of sexual performance in couples affected by ED. With regard to the method of measuring duration, stopwatch method was shown to be reliable and capable of complementing traditional self-assessment efficacy methods for evaluating the efficacy of HS. Hg is the best to significantly improve: Duration of erection in men with ED and Sexual QoL, in both members of a couple affected by ED than EM Absolutely, Hg and EM: Increase duration of erection; Improve sexual pleasure. And, thereby improving the sexual QoL of the COUPLE. And, most important is that sexual couples don’t risk to be un","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"46 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.138
O. Knigavko
The venous leakage is one of the most often reason of erectile dysfunction (ED) in young and middle age men. The main reason of venous leakage or veno-occlusive Erectile Dysfunction (VOED) is the insufficiency venous obstruction under tunica albuginea of corpora cavernosa. Accordingly all types of veno-occlusive operations have particular and short term effect up to renovation of venous leakage in half year. Conservative treatment of VOED with PDE-5 has a low or mild effectiveness. Evermore young patients deny penile prosthesis implantation for psychological reason. We want to stimulate growth of endothelial valves under tunica albuginea with injections autological mesenchymal stem cells (ASC) and autological VEGF (Vascular endothelial growth factor) and combine it with veno-occlusive surgeries. 2012–2022 we treated 178 patients with VOED. The average patient age is 36.5 +4.1 years. Patients with prostatitis or depression/anxiety were excluded from the investigation or treated previously. We embolizated deep dorsal and Santorini plexus veins for patients with distal form of VOED–47 patients -Group 1. We ligated deep dorsal and penile veins for proximal form of VOED – 68 patients – Group 2. And we made both methods together for 65 patients –Group 3 with combination of proximal and distal leak. Patients with only surgical methods created subgroup A – 105 men. For improving of veno-occlusive mechanism for 73 patients (subgroup B) we injected to each corpus cavernosa 1 mln of autological stem cells 6 times (2 times before, during surgery and 3 times after surgery) each month and we performed 15 microinjections of VEGF each 10 days. Then we compared short (2 months) and long term (10 months) results. The efficacy of surgical treatment according to subjective data (questionnaires on IIEF-5) in 2 months was almost equal (16.7+3.1 and 16.9+3.0), but in 10 months significantly higher in SubGroup B(14.3+3.2 and 19.6+3.4). According to Doppler Penile Ultrasound in 10 months adding microinjections ASC and VEGF to surgery significantly improves Erectile function (absence of venous leakage) 56.4% - subgroup A and 87.4% - subgroup B. Only 6.8% patients subgroup B (opposite to 35.9% subgroup A) have to take PDE-5 inhibitors for maintain erectile function. Half year injections of ASC and VEGF improve of veno-occlusive mechanism and increases effectiveness and long term result of veno-occlusive operations for treatment of VOED. Combine occlusive method (embolisation and ligation of veins) has the highest effectiveness and should be used in different types of leakage. No.
{"title":"(152) Efficiency Improvement Veno-Occlusive Surgeries for Treatment of Venous Leak with Autologous Stem Cell, VEGF and PRP","authors":"O. Knigavko","doi":"10.1093/jsxmed/qdae002.138","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.138","url":null,"abstract":"\u0000 \u0000 \u0000 The venous leakage is one of the most often reason of erectile dysfunction (ED) in young and middle age men. The main reason of venous leakage or veno-occlusive Erectile Dysfunction (VOED) is the insufficiency venous obstruction under tunica albuginea of corpora cavernosa. Accordingly all types of veno-occlusive operations have particular and short term effect up to renovation of venous leakage in half year. Conservative treatment of VOED with PDE-5 has a low or mild effectiveness. Evermore young patients deny penile prosthesis implantation for psychological reason.\u0000 \u0000 \u0000 \u0000 We want to stimulate growth of endothelial valves under tunica albuginea with injections autological mesenchymal stem cells (ASC) and autological VEGF (Vascular endothelial growth factor) and combine it with veno-occlusive surgeries.\u0000 \u0000 \u0000 \u0000 2012–2022 we treated 178 patients with VOED. The average patient age is 36.5 +4.1 years. Patients with prostatitis or depression/anxiety were excluded from the investigation or treated previously. We embolizated deep dorsal and Santorini plexus veins for patients with distal form of VOED–47 patients -Group 1. We ligated deep dorsal and penile veins for proximal form of VOED – 68 patients – Group 2. And we made both methods together for 65 patients –Group 3 with combination of proximal and distal leak. Patients with only surgical methods created subgroup A – 105 men. For improving of veno-occlusive mechanism for 73 patients (subgroup B) we injected to each corpus cavernosa 1 mln of autological stem cells 6 times (2 times before, during surgery and 3 times after surgery) each month and we performed 15 microinjections of VEGF each 10 days. Then we compared short (2 months) and long term (10 months) results.\u0000 \u0000 \u0000 \u0000 The efficacy of surgical treatment according to subjective data (questionnaires on IIEF-5) in 2 months was almost equal (16.7+3.1 and 16.9+3.0), but in 10 months significantly higher in SubGroup B(14.3+3.2 and 19.6+3.4). According to Doppler Penile Ultrasound in 10 months adding microinjections ASC and VEGF to surgery significantly improves Erectile function (absence of venous leakage) 56.4% - subgroup A and 87.4% - subgroup B. Only 6.8% patients subgroup B (opposite to 35.9% subgroup A) have to take PDE-5 inhibitors for maintain erectile function.\u0000 \u0000 \u0000 \u0000 Half year injections of ASC and VEGF improve of veno-occlusive mechanism and increases effectiveness and long term result of veno-occlusive operations for treatment of VOED. Combine occlusive method (embolisation and ligation of veins) has the highest effectiveness and should be used in different types of leakage.\u0000 \u0000 \u0000 \u0000 No.\u0000 \u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"354 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.158
B. T. Aujo, N. Nakasujja, A. Turiho, J. L. Gumikiriza, O. Kakaire
Sexual dysfunction is a significant problem among women, and it is associated with maladaptive coping mechanisms that can further worsen the situation. In African regions, the prevalence of female sexual dysfunction (FSD) is highly linked to hormonal contraceptives (HCs), a popular method of birth control. Uganda has a relatively high prevalence of HC use among women of reproductive age. However, there is limited research on sexual dysfunction and coping mechanisms among women who use HCs in Kawempe Hospital. This study aimed to (1) estimate the prevalence of sexual dysfunction among women who use hormonal contraceptives, (2) describe the coping mechanisms used by women who use hormonal contraceptives, and (3) identify the sociodemographic and clinical characteristics associated with sexual dysfunction among women using hormonal contraceptives at Kawempe Hospital. This was a cross-sectional study where sexually active adult females who were on hormonal contraceptives and gave informed consent were consecutively sampled. The female sexual function index and the SexFlex scale were used to assess sexual dysfunction and coping mechanisms of women using hormonal contraceptives. Means, proportions, chi squares and logistic regression were used to describe the population and determine characteristics associated with sexual dysfunction. Of the 401 participants recruited for the study, 386 were analyzed due to 15 incomplete questionnaires. The average age of participants was 29.4 years. Of the participants, almost half 46.6% used implants. The prevalence of FSD was 74.6%. Participants with FSD reported more reflexive 82 (28.47%) and less approach coping 62 (21.53%) than participants without FSD. Factors associated with FSD were relationship dissatisfaction (OR=3.78, 95% CI: 1.68, 8.5), psychological distress (OR=2.12, 95% CI: 1.17, 3.86), finding sex important (OR=0.22, 95%CI: 0.05, 0.88) and approach coping mechanisms (OR=0.49, 95%CI: 0.26, 0.95). FSD was not significantly associated with HCs This study found that women HCs have a high prevalence of FSD that is associated with psychological factors such as relationship dissatisfaction and psychological distress. The study suggests that women using HCs should be regularly screened for FSD and that clinicians should help them find solutions to the underlying causes. No.
{"title":"(174) Sexual Dysfunction and Coping Mechanisms among Women Using Hormonal Contraceptives at Kawempe Hospital - A Cross-Sectional Study","authors":"B. T. Aujo, N. Nakasujja, A. Turiho, J. L. Gumikiriza, O. Kakaire","doi":"10.1093/jsxmed/qdae002.158","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.158","url":null,"abstract":"\u0000 \u0000 \u0000 Sexual dysfunction is a significant problem among women, and it is associated with maladaptive coping mechanisms that can further worsen the situation. In African regions, the prevalence of female sexual dysfunction (FSD) is highly linked to hormonal contraceptives (HCs), a popular method of birth control. Uganda has a relatively high prevalence of HC use among women of reproductive age. However, there is limited research on sexual dysfunction and coping mechanisms among women who use HCs in Kawempe Hospital.\u0000 \u0000 \u0000 \u0000 This study aimed to (1) estimate the prevalence of sexual dysfunction among women who use hormonal contraceptives, (2) describe the coping mechanisms used by women who use hormonal contraceptives, and (3) identify the sociodemographic and clinical characteristics associated with sexual dysfunction among women using hormonal contraceptives at Kawempe Hospital.\u0000 \u0000 \u0000 \u0000 This was a cross-sectional study where sexually active adult females who were on hormonal contraceptives and gave informed consent were consecutively sampled. The female sexual function index and the SexFlex scale were used to assess sexual dysfunction and coping mechanisms of women using hormonal contraceptives. Means, proportions, chi squares and logistic regression were used to describe the population and determine characteristics associated with sexual dysfunction.\u0000 \u0000 \u0000 \u0000 Of the 401 participants recruited for the study, 386 were analyzed due to 15 incomplete questionnaires. The average age of participants was 29.4 years. Of the participants, almost half 46.6% used implants. The prevalence of FSD was 74.6%. Participants with FSD reported more reflexive 82 (28.47%) and less approach coping 62 (21.53%) than participants without FSD. Factors associated with FSD were relationship dissatisfaction (OR=3.78, 95% CI: 1.68, 8.5), psychological distress (OR=2.12, 95% CI: 1.17, 3.86), finding sex important (OR=0.22, 95%CI: 0.05, 0.88) and approach coping mechanisms (OR=0.49, 95%CI: 0.26, 0.95). FSD was not significantly associated with HCs\u0000 \u0000 \u0000 \u0000 This study found that women HCs have a high prevalence of FSD that is associated with psychological factors such as relationship dissatisfaction and psychological distress. The study suggests that women using HCs should be regularly screened for FSD and that clinicians should help them find solutions to the underlying causes.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"282 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.082
N. Thi Huyen Trang, H. Pham Thi My, T. Nguyen Thi Thu, K. Nguyen Thanh, H. Pham Van
Infertility is a significant issue that affects many couples worldwide. Depression is one of the most common psychiatric disorders among infertile patients. This study aims to determine the prevalence of depression and its determinant factors among infertile patients in the Andrology and Fertility Hospital of Hanoi based on the PHQ-9. The study was conducted among 360 infertile patients who visited the Andrology and Fertility Hospital of Hanoi between August 2022 and January 2023. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9). The relationships between depression and demographic/fertility characteristics were explored using univariate and multiple logistic regression with an odds ratio (OR) and 95% confidence interval (CI). The mean total PHQ-9 score was 4.47 (SD = 4.14). Using a cut-off value of 10, the prevalence of depression was 11.7%. Depression was significantly associated with being age over 35 years old (OR = 2.24, 95% CI =1.05 – 4.76), having an income per month of less than 10 million VND (OR=2.01; 95%CI (1.01 – 4.72), husbands feeling pressured to have children (OR = 2.26, 95%CI = 1.08 – 4.72), feeling uncomfortable when others find out about infertility (OR=2.78, 95%CI = 1.36 – 5.67), not receiving support from the workplace (OR=2.55, 95%CI = 1.25 – 5.20) and believing they can be happy without children (OR=4.41, 95%CI = 1.37 – 14.18). The high prevalence of depression among infertile patients in this study highlights the need for healthcare providers to screen and provide psychological support to this population. The finding that female aged above 35, low income, with husbands pressuring them to have kids, feeling uncomfortable when others know about their infertility, and lacking support from their workplace was found to be significant risk factors for depression are significant determinants of depression among infertile patients suggests that interventions should be targeted toward these groups. No.
{"title":"(090) Depression Among Infertile Women: Prevalence and Risk Factors","authors":"N. Thi Huyen Trang, H. Pham Thi My, T. Nguyen Thi Thu, K. Nguyen Thanh, H. Pham Van","doi":"10.1093/jsxmed/qdae002.082","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.082","url":null,"abstract":"\u0000 \u0000 \u0000 Infertility is a significant issue that affects many couples worldwide. Depression is one of the most common psychiatric disorders among infertile patients.\u0000 \u0000 \u0000 \u0000 This study aims to determine the prevalence of depression and its determinant factors among infertile patients in the Andrology and Fertility Hospital of Hanoi based on the PHQ-9.\u0000 \u0000 \u0000 \u0000 The study was conducted among 360 infertile patients who visited the Andrology and Fertility Hospital of Hanoi between August 2022 and January 2023. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9). The relationships between depression and demographic/fertility characteristics were explored using univariate and multiple logistic regression with an odds ratio (OR) and 95% confidence interval (CI).\u0000 \u0000 \u0000 \u0000 The mean total PHQ-9 score was 4.47 (SD = 4.14). Using a cut-off value of 10, the prevalence of depression was 11.7%. Depression was significantly associated with being age over 35 years old (OR = 2.24, 95% CI =1.05 – 4.76), having an income per month of less than 10 million VND (OR=2.01; 95%CI (1.01 – 4.72), husbands feeling pressured to have children (OR = 2.26, 95%CI = 1.08 – 4.72), feeling uncomfortable when others find out about infertility (OR=2.78, 95%CI = 1.36 – 5.67), not receiving support from the workplace (OR=2.55, 95%CI = 1.25 – 5.20) and believing they can be happy without children (OR=4.41, 95%CI = 1.37 – 14.18).\u0000 \u0000 \u0000 \u0000 The high prevalence of depression among infertile patients in this study highlights the need for healthcare providers to screen and provide psychological support to this population. The finding that female aged above 35, low income, with husbands pressuring them to have kids, feeling uncomfortable when others know about their infertility, and lacking support from their workplace was found to be significant risk factors for depression are significant determinants of depression among infertile patients suggests that interventions should be targeted toward these groups.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"203 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.081
B. T. Aujo, N. Nakasujja, A. Turiho, J. L. Gumikiriza, O. Kakaire
Sexual dysfunction is very distressing to women of reproductive age. Hormonal contraceptives (HC) are often reported to be highly associated with sexual dysfunction. The occurrence of female sexual dysfunction (FSD) varies across African regions however, the literature is scanty. This study, therefore aimed to assess the psychological distress (PD) and coping mechanisms of women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital (KH). To determine the prevalence of psychological distress among women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital To examine the factors associated with psychological distress among women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital To evaluate the coping mechanisms of women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital The study was cross-sectional and conducted by a female team at the family planning clinic of KH. Participants were sexually active females aged 18 to 50 years, who had used HCs for at least six months, and had a positive FSD score below 26.55 on the female sexual function index. PD was assessed using the Kessler Psychological Distress Scale K-6, with a score over 13 indicating PD. Coping mechanisms were determined using the SexFlex scale. The data was analyzed using proportions, means, chi-squares and logistic regression to determine characteristics associated with PD at a significance level of 0.05. Of the 401 individuals screened, 288 who had positive FSD scores were enrolled. The average age of the participants was 28.8 years, and 46.18% used implants for contraception. The prevalence of PD was 55.56%, with 28.47% using reflexive-only coping mechanisms, 24.35% using approach-only mechanisms, 13.19% using both, and 63.19% using neither. Being married (AOR=0.45) and breastfeeding (AOR=0.41) were negatively associated with PD, while using injectables (AOR=7.43), implants (AOR=5.17), levonorgestrel IUD (AOR=4.17), having relationship dissatisfaction (AOR=4.65), and sexual pain (AOR=2.60) were positively associated with PD. PD was prevalent among women with FSD using HCs at Kawempe Hospital and associated with modifiable characteristics. It is recommended that health workers regularly screen for PD among women with FSD using HCs and provide education on malleable characteristics, such as breastfeeding and relationship satisfaction. No.
{"title":"(089) Psychological Distress and Coping Mechanisms among Women with Sexual Dysfunction Using Hormonal Contraceptives at Kawempe Hospital - A Cross-sectional Study","authors":"B. T. Aujo, N. Nakasujja, A. Turiho, J. L. Gumikiriza, O. Kakaire","doi":"10.1093/jsxmed/qdae002.081","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.081","url":null,"abstract":"\u0000 \u0000 \u0000 Sexual dysfunction is very distressing to women of reproductive age. Hormonal contraceptives (HC) are often reported to be highly associated with sexual dysfunction. The occurrence of female sexual dysfunction (FSD) varies across African regions however, the literature is scanty. This study, therefore aimed to assess the psychological distress (PD) and coping mechanisms of women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital (KH).\u0000 \u0000 \u0000 \u0000 To determine the prevalence of psychological distress among women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital To examine the factors associated with psychological distress among women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital To evaluate the coping mechanisms of women with sexual dysfunction using hormonal contraceptives at Kawempe Hospital\u0000 \u0000 \u0000 \u0000 The study was cross-sectional and conducted by a female team at the family planning clinic of KH. Participants were sexually active females aged 18 to 50 years, who had used HCs for at least six months, and had a positive FSD score below 26.55 on the female sexual function index. PD was assessed using the Kessler Psychological Distress Scale K-6, with a score over 13 indicating PD. Coping mechanisms were determined using the SexFlex scale. The data was analyzed using proportions, means, chi-squares and logistic regression to determine characteristics associated with PD at a significance level of 0.05.\u0000 \u0000 \u0000 \u0000 Of the 401 individuals screened, 288 who had positive FSD scores were enrolled. The average age of the participants was 28.8 years, and 46.18% used implants for contraception. The prevalence of PD was 55.56%, with 28.47% using reflexive-only coping mechanisms, 24.35% using approach-only mechanisms, 13.19% using both, and 63.19% using neither. Being married (AOR=0.45) and breastfeeding (AOR=0.41) were negatively associated with PD, while using injectables (AOR=7.43), implants (AOR=5.17), levonorgestrel IUD (AOR=4.17), having relationship dissatisfaction (AOR=4.65), and sexual pain (AOR=2.60) were positively associated with PD.\u0000 \u0000 \u0000 \u0000 PD was prevalent among women with FSD using HCs at Kawempe Hospital and associated with modifiable characteristics. It is recommended that health workers regularly screen for PD among women with FSD using HCs and provide education on malleable characteristics, such as breastfeeding and relationship satisfaction.\u0000 \u0000 \u0000 \u0000 No.\u0000","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"24 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1093/jsxmed/qdae002.075
J. Carvalho, J. Oliveira
Psychological models theorizing human sexual response have consistently stressed the role of cognitive factors, namely attention to sexual cues, as a precursor of sexual arousal. Specifically, laboratory studies have focused on (visual)attention as a trigger and maintenance factor of sexual arousal and interest; these studies suggest that sexual stimuli, e.g., stimuli displaying human-realistic nudity and/or sexual intercourse, capture more attention, prompting a sexual response. These studies have settled the basis for psychological interventions in sexual dysfunctions. However, contemporary generations were (sexually)educated and are a product of the digital era, where human-realistic sexual stimuli are no longer the only features people use to induce a sexual response. Female video game characters have “ascended” to the status of sexual stimuli. Animated sexual features are replacing human-realistic ones to induce a sexual response. Yet, sexology research still supports its assumptions on people’s responses to “old fashion” sexual stimuli. Given the lack of laboratory studies using animated sexual features as a frame to study human sexual response - being, therefore, aligned to current preferences regarding what constitutes a sexual stimulus – the current study was aimed at testing the effects of being exposed to a sexualized as compared to a non-sexualized female video game character on men’s (visual)attention, affective and sexual responses. It further tested if the propensity to get sexually aroused predicts men’s responses to sexually animated cues. 46 men (Mage = 25, SD = 8.71) were exposed to the following 2-minute video clips/experimental conditions: 1) a sexualized female video game character, i.e., the character is fighting against a non-human male character, using nothing more than a tie, short bikini; 2) a non-sexualized female character fighting, and wearing a common, practical, outfit, with no evidence of nudity. The video clips were presented in a counterbalanced fashion. The female characters were equal, except for the woman’s clothing and display of nudity. Objective proxies of sexual arousal and interest were captured by an eye tracker (pupil size and dwell time to the sexual features, respectively). Self-reported attention, affective, and sexual responses were also measured. Furthermore, the propensity for sexual excitation was included as a trait sexual dimension. As expected, participants reported being more distracted and sexually aroused during the sexualized experimental condition. Similarly, ocular metrics revealed that during the sexualized condition, participants paid less attention to the game/dangerous cues and spent more time looking at the woman’s body and buttocks. No effects were found regarding pupil size. Findings regarding sexual excitation as a sexual trait showed that the propensity to get sexually aroused predicted increased visual attention, i.e., more interest, to the buttocks
{"title":"(083) Visual Attention, Affective, and Sexual Responses Toward a Sexualized Video Game Female Character","authors":"J. Carvalho, J. Oliveira","doi":"10.1093/jsxmed/qdae002.075","DOIUrl":"https://doi.org/10.1093/jsxmed/qdae002.075","url":null,"abstract":"\u0000 \u0000 \u0000 Psychological models theorizing human sexual response have consistently stressed the role of cognitive factors, namely attention to sexual cues, as a precursor of sexual arousal. Specifically, laboratory studies have focused on (visual)attention as a trigger and maintenance factor of sexual arousal and interest; these studies suggest that sexual stimuli, e.g., stimuli displaying human-realistic nudity and/or sexual intercourse, capture more attention, prompting a sexual response. These studies have settled the basis for psychological interventions in sexual dysfunctions. However, contemporary generations were (sexually)educated and are a product of the digital era, where human-realistic sexual stimuli are no longer the only features people use to induce a sexual response. Female video game characters have “ascended” to the status of sexual stimuli. Animated sexual features are replacing human-realistic ones to induce a sexual response. Yet, sexology research still supports its assumptions on people’s responses to “old fashion” sexual stimuli.\u0000 \u0000 \u0000 \u0000 Given the lack of laboratory studies using animated sexual features as a frame to study human sexual response - being, therefore, aligned to current preferences regarding what constitutes a sexual stimulus – the current study was aimed at testing the effects of being exposed to a sexualized as compared to a non-sexualized female video game character on men’s (visual)attention, affective and sexual responses. It further tested if the propensity to get sexually aroused predicts men’s responses to sexually animated cues.\u0000 \u0000 \u0000 \u0000 46 men (Mage = 25, SD = 8.71) were exposed to the following 2-minute video clips/experimental conditions: 1) a sexualized female video game character, i.e., the character is fighting against a non-human male character, using nothing more than a tie, short bikini; 2) a non-sexualized female character fighting, and wearing a common, practical, outfit, with no evidence of nudity. The video clips were presented in a counterbalanced fashion. The female characters were equal, except for the woman’s clothing and display of nudity. Objective proxies of sexual arousal and interest were captured by an eye tracker (pupil size and dwell time to the sexual features, respectively). Self-reported attention, affective, and sexual responses were also measured. Furthermore, the propensity for sexual excitation was included as a trait sexual dimension.\u0000 \u0000 \u0000 \u0000 As expected, participants reported being more distracted and sexually aroused during the sexualized experimental condition. Similarly, ocular metrics revealed that during the sexualized condition, participants paid less attention to the game/dangerous cues and spent more time looking at the woman’s body and buttocks. No effects were found regarding pupil size. Findings regarding sexual excitation as a sexual trait showed that the propensity to get sexually aroused predicted increased visual attention, i.e., more interest, to the buttocks ","PeriodicalId":377411,"journal":{"name":"The Journal of Sexual Medicine","volume":"32 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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