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2002 IEEE Ultrasonics Symposium, 2002. Proceedings.最新文献

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Subharmonic performance of contrast microbubbles: an experimental and numerical investigation 对比微泡的次谐波性能:实验与数值研究
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192683
W. Shi, L. Hoff, F. Forsberg
The diagnostic capabilities of ultrasound imaging can be improved with contrast-specific nonlinear imaging modalities such as harmonic and subharmonic imaging. The subharmonic performance of the ultrasound contrast agent Sonazoid/sup /spl reg// (Amersham Health, Oslo, Norway) has been investigated experimentally and numerically for the implementation of subharmonic imaging. Strong subharmonic responses were observed from Sonazoid microbubbles in vitro, in vivo and numerically. In conclusion, the scattered subharmonic signal amplitude increases with the total energy within each insonation pulse and depends strongly on the polarity of short insonation pulses.
超声成像的诊断能力可以提高与对比度特定的非线性成像模式,如谐波和次谐波成像。对超声造影剂Sonazoid/sup /spl reg// (Amersham Health, Oslo, Norway)的亚谐波成像性能进行了实验和数值研究。在体外、体内和数值上观察了索那唑类微泡的强次谐波响应。综上所述,散射次谐波信号幅值随每个超声脉冲内总能量的增加而增加,并与短超声脉冲的极性密切相关。
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引用次数: 18
Development of ultrasonic techniques with buffer rod in molten aluminum 铝液缓冲棒超声技术的发展
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193520
Y. Ono, J. Moisan, C. Jen, D. R. França
The development of ultrasonic techniques for imaging and measurements in molten aluminum (Al) using clad buffer rods operated at 10 MHz is presented. The ultrasonic image of a character "N", engraved on a stainless steel plate immersed in molten Al, has been observed at 780/spl deg/C using the focused probe. Inclusion detection experiments have been conducted in reflection configurations involving pitch-catch and pulse-echo modes. The backscattered ultrasonic signals from the silicon carbide particles with an averaged diameter of 50 /spl mu/m suspended in molten Al are successfully detected due to the high signal-to-noise ratio of the clad buffer rods.
介绍了利用10兆赫频率的包层缓冲棒在熔融铝(Al)中成像和测量的超声技术的发展。在780/spl℃的温度下,用聚焦探头观察了不锈钢板上刻字“N”的超声图像。在基音捕捉和脉冲回波两种反射模式下进行了包体检测实验。由于包覆缓冲棒的高信噪比,悬浮在Al熔液中的平均直径为50 /spl μ m的碳化硅颗粒能够成功地检测到后向散射超声信号。
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引用次数: 13
Microbubble destruction-reperfusion in the non-invasive measurement of the vascular targeting effects of the anti-cancer drug ZD6126 微泡破坏-再灌注在无创测量抗癌药物ZD6126血管靶向作用中的应用
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192691
R. Karshafian, P. Burns, X. Qi, Mingyu Zhang
A new and promising strategy in cancer therapy targets the proliferating endothelium of a tumour's blood vessels rather than the cells of the cancer itself. Among other advantages, such therapies may evade the drug resistance that many tumours acquire during treatment, rendering the drugs appropriate for long term use. However, because the tumour vasculature lies below the threshold of detection for conventional radiological techniques, new methods are required to determine the effect of such therapy on the tumour microvasculature. The combination of microbubble contrast and nonlinear imaging methods such as pulse inversion Doppler have been shown capable of detecting (but not resolving) flow at the capillary level. In this study, we use a combination of microbubble destruction-reperfusion flow measurement and real time contrast Imaging to assess the effects of an anti-vascular agent ZD6126 (AstraZeneca Inc, NJ) on experimental VX-2 tumours in the rabbit. The active component of this drug, N-acetyl colchinol, causes tubulin depolymerisation, thereby inducing neovascular endothelial cell rounding and subsequent vascular collapse. The effect is selective to tumour blood vessels (whose endothelial cells rely on tubulin for their structure) and is thought to be an acute one, occurring within hours of administration of the drug. Our objectives in this study were to make haemodynamic measurements of tumour blood flow rate and vascular volume, then to use these to determine dose response to the anti-vascular drug and to demonstrate the evolution of this effect with time following drug administration. We intended that the method used should employ a commercially available scanner and be suitable for translation to clinical contrast imaging of breast cancers.
一种新的有前途的癌症治疗策略针对肿瘤血管的增殖内皮,而不是癌症本身的细胞。除其他优点外,这种疗法可以避免许多肿瘤在治疗期间获得的耐药性,使药物适合长期使用。然而,由于肿瘤血管系统低于常规放射技术的检测阈值,需要新的方法来确定这种治疗对肿瘤微血管系统的影响。结合微泡对比和非线性成像方法,如脉冲逆多普勒,已被证明能够检测(但不能分辨)毛细血管水平的流动。在这项研究中,我们使用微泡破坏-再灌注流量测量和实时对比成像相结合的方法来评估抗血管剂ZD6126(阿斯利康公司,NJ)对兔实验性VX-2肿瘤的影响。该药物的活性成分n -乙酰秋大麻醇可引起微管蛋白解聚合,从而诱导新生血管内皮细胞成圆和随后的血管塌陷。这种效果对肿瘤血管(其内皮细胞依赖于微管蛋白的结构)是选择性的,并且被认为是急性的,在给药后几小时内就会发生。在这项研究中,我们的目标是对肿瘤血流速率和血管体积进行血流动力学测量,然后用这些数据来确定抗血管药物的剂量反应,并证明这种效应随药物给药后时间的演变。我们的目的是,所使用的方法应采用市售扫描仪,并适用于乳腺癌的临床对比成像。
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引用次数: 1
A highly efficient 20 MHz piezo-composite transducer for nondestructive characterization of multilayer plastics 用于多层塑料无损表征的高效20mhz压电复合传感器
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193499
Q. Xue, A. Abbate, G. Elfbaum, Y. Shui, Haodong Wu
Fabrication of piezo-composite transducers over 20 MHz by the dice-and-fill method is a challenge to the industry. This paper reports a newly developed 20 MHz single element composite transducer using the dice-and-fill method. The transducer exhibited significant improvement in sensitivity of more than 10 dB in measurement of plastics as compared to standard piezo-ceramic transducers having similar size and electrical impedance. The high efficiency of the composite transducer was achieved by optimizing composite design to a configuration with maximum thickness coupling coefficient of the material. Meanwhile, the polymer and ceramic phases of the composite efficiently oscillate in phase. This design also allows the piezo-composite to be fabricated for frequencies higher than 20 MHz with a low aspect ratio where lateral modes usually dominate. However, with the optimized design, lateral modes are suppressed and almost invisible within usable bandwidths up to 40 MHz. Measurement of thin barrier layer samples using the 20MHz composite transducer demonstrated consistent results for a thickness of 0.084 mm, while the standard 20 MHz transducers are only able to resolve thickness above 0.100 mm.
用掷骰子和填充法制造超过20mhz的压电复合换能器对工业来说是一个挑战。本文报道了一种新研制的20 MHz单元件复合换能器。与具有相似尺寸和电阻抗的标准压电陶瓷换能器相比,该换能器在测量塑料时的灵敏度显着提高了10 dB以上。通过优化复合设计,使材料的厚度耦合系数达到最大,实现了复合换能器的高效率。同时,复合材料的聚合物相和陶瓷相具有有效的相振荡。这种设计也允许压电复合材料制造频率高于20 MHz,具有低纵横比,横向模式通常占主导地位。然而,通过优化设计,横向模式被抑制,并且在高达40mhz的可用带宽内几乎不可见。使用20MHz复合换能器测量薄阻挡层样品显示出厚度为0.084 mm的一致结果,而标准20MHz换能器只能解决0.100 mm以上的厚度。
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引用次数: 1
Utilization of the high-frequency piezoelectric ceramic hollow spheres for exposimetry and tissue ablation 高频压电陶瓷空心球在暴露测量和组织消融中的应用
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192575
O. Al-Bataineh, R. Meyer, R.E. Newnharn, N. Smith
Miniature, high-frequency piezoelectric ceramic hollow spheres were evaluated for potential use as hydrophones for exposimetry of high intensity ultrasound fields and as minimally invasive ablation devices. As a hydrophone, the hollow sphere has unique characteristics regarding its geometry, dimensions and sensitivity, which make it ideal for use in exposimetry of high pressure fields. Spheres with diameters ranging from 0.7 to 1.0 mm and with resonance frequencies from 1.8 to 2.7 MHz were used as hydrophones. A relative (reciprocal) calibration method was performed to determine the end-of-cable sensitivity as well as the directivity of the hollow sphere hydrophones. An almost constant sensitivity was reported for the spherical hydrophones and an omni-directional receive pattern was also demonstrated. The hollow sphere hydrophone was shown to have twice the sensitivity of a needle type hydrophone but with no pre-amplification stages and could withstand four times the pressure. As a minimally invasive interstitial ablation device, several in vitro experiments were conducted using two different size spheres. The results demonstrated an increased necrosed tissue volume for increasing exposure time. With a 1.0 mm diameter sphere (f = 1.87 MHz), the necrosed tissue diameter as a function of exposure times was 2.35 /spl plusmn/ 0.34, 3.00 /spl plusmn/ 0.37 and 4.61 /spl plusmn/ 1.13 mm for 5, 10 and 15 second sonications, respectively. Using a 0.7 mm diameter sphere (f = 2.70 MHz), the size of the ablated tissue was 1.50 /spl plusmn/ 0.01 and 1.63 /spl plusmn/ 0.31 mm for 5 and 10 seconds sonications, respectively. As a tissue ablation device, the hollow sphere was able to produce controllable lesion diameters with sharp boundaries between the normal and necrosed tissue.
微型高频压电陶瓷空心球作为高强度超声场暴露的水听器和微创消融装置的潜在用途进行了评估。作为一种水听器,空心球在几何形状、尺寸和灵敏度方面具有独特的特点,是高压场暴露测量的理想选择。直径为0.7 ~ 1.0 mm,共振频率为1.8 ~ 2.7 MHz的球体被用作水听器。采用相对(倒数)定标法测定了空心球水听器的缆端灵敏度和指向性。报道了球形水听器几乎恒定的灵敏度,并证明了全向接收模式。空心球体水听器的灵敏度是针型水听器的两倍,但没有预放大级,可以承受四倍的压力。作为一种微创间质消融装置,使用两种不同大小的球体进行了多次体外实验。结果表明,随着暴露时间的增加,坏死组织体积增加。对于直径为1.0 mm的球体(f = 1.87 MHz),在5、10和15秒的超声条件下,坏死组织直径随暴露时间的变化分别为2.35 /spl plusmn/ 0.34、3.00 /spl plusmn/ 0.37和4.61 /spl plusmn/ 1.13 mm。使用直径为0.7 mm的球体(f = 2.70 MHz),超声时间为5秒和10秒,消融组织的大小分别为1.50 /spl plusmn/ 0.01和1.63 /spl plusmn/ 0.31 mm。作为一种组织消融装置,空心球体能够产生可控制的病变直径,在正常组织和坏死组织之间有明确的界限。
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引用次数: 3
Novel optical observation technique for shear horizontal wave in SAW resonators on 42/spl deg/YX-cut lithium tantalate 42/spl度/ yx切割钽酸锂表面波共振腔剪切水平波光学观测新技术
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193359
A. Miyamoto, S. Wakana, A. Ito
We developed a new optical technique for observing the shear horizontal component of surface acoustic waves. The technique detects the change in polarization of the probe light caused by the photoelastic effect. We measured the distribution in and around a resonator on rotated Y-cut LiTaO/sub 3/, and occurrence and propagation of leakage was observed.
我们开发了一种新的观测表面声波剪切水平分量的光学技术。该技术探测到由光弹性效应引起的探针光偏振变化。在旋转y型切割LiTaO/sub 3/上测量了谐振腔内部和周围的分布,观察了泄漏的发生和传播。
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引用次数: 21
Temperature stability of surface acoustic wave resonators on the in-plane rotated 33/spl deg/Y-cut quartz 面内旋转33/声压角/ y形石英表面声波谐振器的温度稳定性
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193362
S. Kanna, K. Iizawa, T. Yamazaki, M. Takagi
We present surface acoustic wave resonators on the in-plane rotated 33/spl deg/Y-cut quartz with improved temperature stability. We calculate the frequency temperature characteristics of Rayleigh waves using finite element method under the condition of Euler angle (0, 123, 39-44). We confirmed the accuracy of calculated temperature coefficients by experiments. We also measured the resonance characteristics of prototype SAW resonators.
我们在平面内旋转33/spl度/ y形切割石英上提出了表面声波谐振器,提高了温度稳定性。在欧拉角(0,123,39-44)条件下,用有限元法计算了瑞利波的频率温度特性。通过实验验证了计算温度系数的准确性。我们还测量了原型SAW谐振器的谐振特性。
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引用次数: 7
Calculation of COM parameters for an arbitrary IDT cell 计算任意IDT单元的COM参数
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193399
S. Malocha, B. Abbott
In this paper a fast and accurate method to calculate COM parameters (transduction and reflectivity) of a transducer cell with any arbitrary geometry and polarity sequence is presented. This method was applied to optimization of SPUDT cells on different materials. SPUDT structures with three and four electrodes per wavelength have been optimized for several different substrates. Very good agreement between predicted and experimental results is shown for SPUDT transducers on quartz, langasite and lithium tantalate.
本文提出了一种快速准确地计算任意几何形状和极性序列的换能器单元的COM参数(转导和反射率)的方法。将该方法应用于SPUDT细胞在不同材料上的优化。每个波长有三个和四个电极的SPUDT结构已经针对几种不同的衬底进行了优化。在石英、langasite和钽酸锂上的SPUDT换能器的预测结果与实验结果非常吻合。
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引用次数: 7
Study on ultrasound transducer with double peak type frequency characteristics for sub-harmonic imaging 用于次谐波成像的双峰型超声换能器的研究
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192486
S. Takeuchi, M.R.A. Al Zaabi, T. Sato, N. Kawashima
In this study, an ultrasound transducer with double peak type frequency characteristics having a peak on the high frequency side for illuminating ultrasound to tissues or microbubbles in the human body and a peak on the low frequency side for detecting sub-harmonic component from microbubbles was designed with numerical calculations and fabricated as the one for sub-harmonic imaging. The trial ultrasound transducer was confirmed to have the double peak type frequency characteristics of transmitting and receiving sensitivity adapted to sub-harmonic imaging.
本研究通过数值计算设计并制作了一种双峰型频率特性的超声换能器,该换能器高频侧有一个峰值用于对人体组织或微泡进行超声照射,低频侧有一个峰值用于检测微泡中的次谐波成分。试验超声换能器具有双峰型频率特性,发射和接收灵敏度适合于次谐波成像。
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引用次数: 2
Interaction between leaky surface acoustic waves in periodic gratings of thick metal electrodes 厚金属电极周期光栅中泄漏表面声波的相互作用
Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193415
V.I. Grigorievski
It is shown that effective permittivity function in the complex plane of slowness for 36-42 degrees rotated lithium tantalate substrates apart from the well-known LSAW exhibits an additional singular point. The pole is located between "fast shear" and "longitudinal" branch points and can be numerically found out when appropriate branch line is drawn from the "fast shear" branch point. The effective propagation velocity of this leaky mode on 36 degrees rotated lithium tantalate equals 4723 m/s that is 1.1 times larger than the velocity of fast shear SSBW propagating in the same direction. The intrinsic attenuation of this mode is extremely high and equal to 6.93 dB/wavelength. The previously reported PSAW-like mode in periodic system of metal electrodes is associated with this new mode.
结果表明,除了已知的LSAW外,36-42度旋转钽酸锂衬底的有效介电常数函数在慢速复平面上呈现一个额外的奇点。极点位于“快剪”支点与“纵”支点之间,从“快剪”支点处画出合适的支线即可数值求出。该泄漏模式在36度旋转的钽酸锂上的有效传播速度为4723 m/s,是同方向快速剪切SSBW传播速度的1.1倍。这种模式的固有衰减非常高,等于6.93 dB/波长。先前报道的金属电极周期系统中的类psaw模式与这种新模式有关。
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引用次数: 1
期刊
2002 IEEE Ultrasonics Symposium, 2002. Proceedings.
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