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A roadmap for improving representation in clinical trials 提高临床试验代表性的路线图
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-23 DOI: 10.1016/j.conctc.2024.101374
Clinical trials continue to struggle with recruiting diverse participants that include historically underrepresented and minoritized patients, who are typically patients in non-white racial and ethnic groups and have low income (Medicaid). Enrolling diverse participants will benefit the health sciences by providing more generalizable findings. The Cancer Financial Experience project (CAFÉ) study sought to improve financial distress by providing financial navigation for newly diagnosed cancer patients, and intentionally recruited diverse participants. All diverse participants consented at slightly higher rates than non-diverse participants (21.3 % vs. 20.1 %). Spanish-speaking patients consented at a much higher rate than non-Spanish speakers (36.4 % vs. 20.2 % respectively). Here we discuss how we increased our recruitment of diverse participants. Obtaining diverse participation is achievable and will provide more meaningful findings.
临床试验在招募多元化参与者方面仍有困难,这些参与者包括历来代表性不足的少数群体患者,他们通常是非白人种族和民族群体的患者以及低收入者(医疗补助)。招募多样化的参与者将有利于健康科学的发展,提供更具普遍性的研究结果。癌症财务体验项目(CAFÉ)研究旨在通过为新诊断的癌症患者提供财务指导来改善财务困境,并有意招募了不同的参与者。所有多元化参与者的同意率略高于非多元化参与者(21.3% 对 20.1%)。西班牙语患者的同意率远远高于非西班牙语患者(分别为 36.4% 对 20.2%)。在此,我们将讨论如何增加对不同参与者的招募。多元化参与是可以实现的,并将提供更有意义的研究结果。
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引用次数: 0
The safety and feasibility of transcranial direct current stimulation combined with conservative treatment for patients with cervicogenic headaches: A double-blinded randomized control study protocol 经颅直流电刺激联合保守治疗颈源性头痛患者的安全性和可行性:双盲随机对照研究方案
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-19 DOI: 10.1016/j.conctc.2024.101370

Background

Cervicogenic headaches (CGH) are common following concussion and whiplash injuries and significantly reduce patient quality of life. Conservative therapies such as ET (ET) and physiotherapy combined with injection-based therapies are cornerstones of treatment for CGH but have shown limited efficacy. Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has shown promise in treating other chronic pain conditions. The primary aim of this trial is to evaluate the feasibility and safety of tDCS when combined with ET for the treatment of CGH.

Methods

Adults (aged 18–65), blinded to treatment arm, will be randomized into one of two groups: active tDCS followed by ET or sham tDCS followed by ET. Transcranial direct current stimulation will be applied over M1 three times per week for 6-weeks and ET will be performed daily. The primary outcomes of this trial will be the feasibility and safety of the intervention. Feasibility will be defined as greater than 30 % recruitment, 70 % protocol adherence, and 80 % retention rate. Safety will be defined as no severe adverse events. Secondary exploratory outcomes will assess improvement in pain, strength, function, and quality of life.

Conclusions

This trial aims to demonstrate the safety and feasibility of tDCS in combination with ET for the treatment of CGH. Cervicogenic headaches can be difficult to treat contributing to significant impairments function and quality of life. Transcranial direct current stimulation is a potential novel treatment to improve health outcomes in these patients.

Registration

ClinicalTrials.gov-NCT05582616.
背景颈源性头痛(CGH)是脑震荡和鞭打伤后的常见病,严重降低了患者的生活质量。ET和物理疗法等保守疗法结合注射疗法是治疗颈源性头痛的基础,但疗效有限。对初级运动皮层(M1)的经颅直流电刺激(tDCS)已显示出治疗其他慢性疼痛病症的前景。本试验的主要目的是评估经颅直流电刺激(tDCS)与ET联合治疗CGH的可行性和安全性。方法成人(18-65岁)将被随机分为两组:主动经颅直流电刺激组(active tDCS)和假经颅直流电刺激组(sham tDCS)。经颅直流电刺激将应用于 M1,每周三次,持续 6 周,ET 将每天进行。本试验的主要结果是干预的可行性和安全性。可行性的定义是招募率超过 30%,方案遵守率超过 70%,保留率超过 80%。安全性的定义是无严重不良事件发生。次要探索性结果将评估疼痛、力量、功能和生活质量的改善情况。结论这项试验旨在证明 tDCS 联合 ET 治疗颈源性头痛的安全性和可行性。颈源性头痛很难治疗,会严重影响患者的功能和生活质量。经颅直流电刺激是一种潜在的新型疗法,可改善这些患者的健康状况。RegistrationClinicalTrials.gov-NCT05582616.
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引用次数: 0
Constricting Gaps: Protocol development, implementation challenges and lessons learned for the reality map of unmet needs for Palliative Care Interventions in advanced cancer patients study in Romania and Switzerland 缩小差距:罗马尼亚和瑞士晚期癌症患者姑息关怀干预未满足需求现实图研究的协议制定、实施挑战和经验教训
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-17 DOI: 10.1016/j.conctc.2024.101360

Background

Patients with advanced cancer experience many symptoms and needs requiring a Palliative Care Intervention (PCI). Identifying gaps between needs for PCIs and experienced delivery may improve health care, furthermore the association of gaps with quality indicators (QI). The multicentre Romanian (RO)-Swiss (CH) reality map study implemented a novel protocol based on needs concepts and culturally adapted quality indicators (QI).

Methods

An interactive mapping guide measuring unmet needs for PCIs monthly over six months, patient characteristics (cognition, EAPC basic data set, Cofactors) and QI (Inappropriate Anticancer Treatment, High Symptom Burden [IPOS, EQ5D], Repeated ER Admissions, Aggressive End-of-Life Care, and Quality of Death-and-Dying) were developed, applying swiss standards for quality assurance. A composite endpoint (QI, cofactors) was planned. Finally, local solutions responding to gaps were piloted.

Results

From 308 patients (RO: 262, CH: 46, age 62j [mean], 74 % ECOG PS 1&2, 81 % current anticancer treatment) baseline and first follow-up data revealed main gaps (symptom management, spiritual needs, family support), country differences (e.g. illness understanding, spiritual needs) and a significant association of the number of gaps with depression. Later data become less, and data quality on QI variable, revealing gaps in research conduct competences, resources, and applicability of over-sophisticated quality assurance tools. Nevertheless, the unmet needs data promoted local initiatives, 81 patients participated in feasibility studies. Finally, the joint experience stimulated academic developments and national integration of palliative care into oncology.

Conclusions

Pairing motivation and enthusiasm with more modest aims, feasibility testing of all outcomes and investment in research competences may disperse gaps.

背景晚期癌症患者有许多症状和需求,需要姑息治疗干预(PCI)。找出PCI需求与经验提供之间的差距可以改善医疗服务,并将差距与质量指标(QI)联系起来。罗马尼亚(RO)-瑞士(CH)多中心现实地图研究根据需求概念和文化适应性质量指标(QI)实施了一项新方案。方法应用瑞士的质量保证标准,开发了一个交互式绘图指南,用于测量未满足的六个月内每月 PCIs 需求、患者特征(认知、EAPC 基本数据集、Cofactors)和 QI(不恰当的抗癌治疗、高症状负担 [IPOS、EQ5D]、重复急诊入院、积极的生命末期护理和临终质量)。还规划了一个综合终点(质量指标、辅助因素)。结果从 308 名患者(瑞士:262 人,中国:46 人,平均年龄 62 岁,74% ECOG PS 1&2,81% 正在接受抗癌治疗)的基线和首次随访数据中发现了主要差距(症状管理、精神需求、家庭支持)、国家差异(如对疾病的理解、精神需求)以及差距数量与抑郁的显著关联。后来的数据变得越来越少,有关质量保证的数据质量也参差不齐,显示出在研究能力、资源和过于复杂的质量保证工具的适用性方面存在差距。尽管如此,未满足需求的数据促进了当地的主动行动,81 名患者参与了可行性研究。最后,联合经验促进了学术发展和国家将姑息关怀纳入肿瘤学的进程。结论将积极性和热情与更适度的目标相结合,对所有结果进行可行性测试,并对研究能力进行投资,可以消除差距。
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引用次数: 0
Protocol for COACH, an evidence-based intervention for improved head impact safety in youth American football developed using a community-engaged approach COACH 协议,这是一项以证据为基础的干预措施,旨在通过社区参与的方式改善青少年美式橄榄球的头部撞击安全。
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-17 DOI: 10.1016/j.conctc.2024.101371

Subconcussive, repetitive head impacts sustained in collision sports may negatively affect brain health. American football practices are controlled environments amenable to intervention. Engaging community members is essential for successful development, implementation, and sustainability of viable interventions. The objective of this study is to develop and pilot test an evidence-based intervention to reduce head impact exposure in youth American football (i.e., football), using a community-engaged approach. This manuscript describes the co-design of the intervention and associated implementation plan and the study protocol for evaluating the effectiveness and feasibility of the intervention and implementation plan. In the first part of this study, focus groups with parents and coaches, and individual interviews with organizational leaders associated with two teams at the middle school level were conducted. An anonymous survey assessing beliefs and perceptions of non-concussive head impacts was given to parents, coaches, and organizational leaders within the local youth football league. Following the football season, qualitative and quantitative data describing determinants of head acceleration events in football were shared with 12 stakeholders of coaches, league and school administrators, parents, an athletic trainer, and local university player development director. Together, we co-designed COACH (COmmunities Aligned to reduce Concussion and Head impact exposure) and implementation plan using a strategic planning approach. The preliminary effectiveness and feasibility were assessed in the second part of this study. Youth football players participating on the teams in year 1 (control teams) were fitted with mouthpiece-based head kinematic sensors which measure head acceleration events (HAEs). HAEs were collected and quantified during team activities. Preliminary effectiveness of the intervention to reduce HAEs was measured among two new teams pilot testing COACH with mouthpiece-based sensors, while simultaneously monitoring implementation of the intervention. We report our study design and evaluation, and opportunities and challenges with our approach. The results will inform a future full-scale pragmatic trial to assess the implementation and effectiveness of the intervention program.

NCT04908930.

碰撞运动中头部受到的次撞击和重复撞击可能会对大脑健康产生负面影响。美式橄榄球训练是一种可控环境,适合采取干预措施。社区成员的参与对于可行干预措施的成功开发、实施和可持续性至关重要。本研究的目的是采用社区参与的方法,开发并试点测试一种循证干预措施,以减少青少年美式橄榄球(即足球)运动中的头部撞击。本手稿介绍了干预措施和相关实施计划的共同设计,以及评估干预措施和实施计划的有效性和可行性的研究方案。在研究的第一部分,对家长和教练进行了焦点小组讨论,并对与中学两支球队相关的组织领导进行了个别访谈。此外,还向当地青少年足球联赛的家长、教练和组织领导者发放了一份匿名调查问卷,评估他们对非撞击性头部撞击的信念和看法。足球赛季结束后,我们与教练、联赛和学校管理人员、家长、运动训练师和当地大学球员发展主任等 12 名利益相关者分享了描述足球运动中头部加速事件决定因素的定性和定量数据。我们采用战略规划方法,共同设计了 COACH(减少脑震荡和头部撞击的社区联盟)和实施计划。本研究的第二部分对初步的有效性和可行性进行了评估。参加第一年级球队(对照组)的青少年足球运动员都安装了口罩式头部运动传感器,用于测量头部加速度事件(HAE)。在球队活动中收集并量化 HAEs。在两支新队伍中,对使用口罩式传感器的 COACH 进行了试点测试,同时对干预措施的实施情况进行了监测,以衡量干预措施在减少 HAE 方面的初步效果。我们报告了我们的研究设计和评估,以及我们的方法所面临的机遇和挑战。研究结果将为未来的全面务实试验提供参考,以评估干预计划的实施情况和有效性。
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引用次数: 0
Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes: Rationale and design of a two-armed double blind randomized controlled trial 两种药物护肤霜对糖尿病患者脚部干燥症的治疗效果:双臂双盲随机对照试验的原理与设计
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-16 DOI: 10.1016/j.conctc.2024.101372

Introduction

To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without foot-ulcers using two skincare creams containing different humectants (interventions) against a cream base non-humectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, low-molecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams.

Methods

Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28.

Discussion

This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.

导言:为了最大限度地降低患足部溃疡的风险,糖尿病患者被建议每天检查足部并使用护肤配方。然而,市面上很少有专门针对糖尿病足护理而开发和评估的护肤产品。这项随机对照试验(RCT)的主要目的是评估使用两种含有不同保湿剂的护肤霜(干预措施)和一种不含保湿剂的护肤霜(对比试验)对减轻无足部溃疡的糖尿病患者足部干燥症的效果。次要结果是评估干预药膏与对比药膏之间在皮肤屏障完整性、低分子量生物标志物和皮肤微生物群、微循环(包括经皮氧压)、神经病变程度和 HbA1c 方面的差异:NCT06427889。在80%的功率下,每组的双尾显著性为2.5%,每组需要39名研究人员,共78人(包括退出者98人),才能证明干预药膏与对比药膏相比,在 "角化严重程度量表"(Xerosis Severity Scale)中至少降低了一个等级。在一个治疗组中,每位受试者的一只脚使用一种干预药膏(Oviderm® 或 Canoderm®),另一只脚使用对比药膏(Decubal® 脂质药膏),每天两次。如有需要,参与者可在两周的冲洗期后参加治疗。本研究评估了护肤霜中的保湿剂对糖尿病患者足部干燥症的潜在作用。
{"title":"Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes: Rationale and design of a two-armed double blind randomized controlled trial","authors":"","doi":"10.1016/j.conctc.2024.101372","DOIUrl":"10.1016/j.conctc.2024.101372","url":null,"abstract":"<div><h3>Introduction</h3><p>To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without foot-ulcers using two skincare creams containing different humectants (interventions) against a cream base non-humectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, low-molecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams.</p></div><div><h3>Methods</h3><p>Two-armed double-blind RCT, registered in <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28.</p></div><div><h3>Discussion</h3><p>This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.</p></div>","PeriodicalId":37937,"journal":{"name":"Contemporary Clinical Trials Communications","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451865424001194/pdfft?md5=f48333f5855f1319b1cce6062b04605d&pid=1-s2.0-S2451865424001194-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and effectiveness of cardiac telerehabilitation for older adults with coronary heart disease: A pilot randomized controlled trial 为患有冠心病的老年人提供心脏远程康复服务的可行性和有效性:随机对照试验
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-12 DOI: 10.1016/j.conctc.2024.101365

Background

Cardiac rehabilitation is a beneficial multidisciplinary treatment of exercise promotion, patient education, risk factor management, and psychosocial counseling for people with coronary heart disease (CHD) that is underutilized due to substantial disparities in access, referral, and participation. Empirical studies suggest that cardiac telerehabilitation (CTR) have safety and efficacy comparable to traditional in-person cardiac rehabilitation, however, older adults are under-reported with effectiveness, feasibility, and usability remains unclear.

Methods

The study randomized 43 older adults (84 % males) to the 12-week CTR intervention or standard of care. Guided by Social Cognitive Theory, participants received individualized in-person assessment and e-coaching sessions, followed by CTR usage at home. Data were collected at baseline (T0), six-week (T1), and 12-week (T2).

Results

Participants in the CTR intervention group showed significant improvement in daily steps (T1: β = 4126.58, p = 0.001; T2: β = 5285, p = 0.01) and health-promoting lifestyle profile (T1: β = 23.26, p < 0.001; T2: β = 12.18, p = 0.008) across study endpoints. Twenty participants completed the intervention, with 40 % used the website for data-uploading or experiential learning, 90 % used the pedometer for tele-monitoring. Improving awareness of rehabilitation and an action focus were considered key facilitators while physical discomforts and difficulties in using the technology were described as the main barriers.

Conclusions

The CTR is feasible, safe and effective in improving physical activity and healthy behaviors in older adults with CHD. Considering the variation in individual cardiovascular risk factors, full-scale RCT with a larger sample is needed to determine the effect of CTR on psychological symptoms, body weight and blood pressure, and quality of life.

背景心脏康复是一种有益的多学科治疗方法,包括运动促进、患者教育、危险因素管理和冠心病患者的心理咨询,但由于在获取、转诊和参与方面存在巨大差异,因此未得到充分利用。经验性研究表明,心脏远程康复(CTR)的安全性和有效性可与传统的面对面心脏康复相媲美,但是,老年人对其有效性、可行性和可用性的报告不足,目前仍不清楚。方法该研究将 43 名老年人(84% 为男性)随机分配到为期 12 周的 CTR 干预或标准护理中。在社会认知理论的指导下,参与者接受了个性化的面对面评估和电子辅导课程,随后在家中使用 CTR。在基线(T0)、6 周(T1)和 12 周(T2)收集数据。结果CTR 干预组的参与者在各研究终点的每日步数(T1:β = 4126.58,p = 0.001;T2:β = 5285,p = 0.01)和促进健康的生活方式(T1:β = 23.26,p < 0.001;T2:β = 12.18,p = 0.008)方面均有显著改善。20名参与者完成了干预,其中40%的人使用网站上传数据或进行体验式学习,90%的人使用计步器进行远程监测。提高康复意识和行动重点被认为是主要的促进因素,而身体不适和使用技术的困难被认为是主要障碍。考虑到个体心血管风险因素的差异,需要进行更大规模的样本研究,以确定 CTR 对心理症状、体重和血压以及生活质量的影响。
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引用次数: 0
Get BusActive!: Protocol of a single-blinded randomised controlled trial incentivising public transport use for physical activity gain among young people and adults Get BusActive!单盲随机对照试验方案:鼓励年轻人和成年人使用公共交通以增加体育活动量
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-11 DOI: 10.1016/j.conctc.2024.101367

Background

Population level physical activity generally does not meet recommended targets. Compared with private motor vehicle users, public transport users tend to be more physically active and financial incentives may encourage more public transport use, but these relationships are under-investigated. This paper describes the protocol of a randomised controlled trial that aimed to determine the effect of financially incentivising public transport use on physical activity in a regional Australian setting.

Methods

Get BusActive! is a 9.5-month single-blinded randomised controlled trial. A convenience sample of Tasmanians aged ≥15 years will be randomised to a 14-week incentive-based intervention (bus trip target attainment rewarded by bus trip credits and weekly supportive text messages) or an active control following baseline measures and will be followed up ∼24 weeks later (maintenance phase). Both groups will receive written physical activity guidelines. The primary outcome is change in accelerometer-measured steps/day from baseline to immediately post intervention phase and maintenance phase. Secondary outcomes are change in: smartcard-measured bus trips/week; measured and self-reported minutes/week of physical activity and sitting; transport-related behaviour (using one-week travel diary), perspectives (e.g. enablers/barriers) and costs; health. Linear mixed model regression will determine group differences. Participant-level process evaluation will be conducted and intervention cost to the public transport provider determined.

Conclusion

Get BusActive! will fill an important knowledge gap about the causal relationship between financially incentivised public transport use and physical activity—the findings will benefit health and transport-related decision makers.

Trial registration

ACTRN12623000613606.

Universal trial number

U1111-1292-3414.

背景人群的体力活动一般达不到建议的目标。与私家车用户相比,公共交通用户往往更积极参加体育锻炼,经济激励措施可能会鼓励更多的人使用公共交通,但对这些关系的研究还不够。本文介绍了一项随机对照试验的方案,该试验旨在确定在澳大利亚地区环境中使用公共交通的经济激励措施对身体活动的影响。我们将对年龄≥15 岁的塔斯马尼亚人进行随机抽样,在进行基线测量后,将他们随机分配到为期 14 周的激励性干预措施(通过公交出行积分和每周支持性短信奖励达到公交出行目标)或积极对照组,并在 24 周后进行随访(维持阶段)。两组都将收到书面的体育锻炼指南。主要结果是加速度计测量的步数/天从基线到干预阶段后和维持阶段的变化。次要结果是以下方面的变化:智能卡测量的公交车出行次数/周;测量和自我报告的体育活动和坐姿的分钟/周;与交通有关的行为(使用一周的出行日记)、观点(如促进因素/障碍)和成本;健康。线性混合模型回归将确定组间差异。结论Get BusActive! 将填补有关经济激励的公共交通使用与身体活动之间因果关系的重要知识空白--研究结果将使健康和交通相关决策者受益。
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引用次数: 0
The impact of internet connectivity when conducting a virtual clinical trial with participants living in rural areas 为农村地区参与者开展虚拟临床试验时互联网连接的影响
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-10 DOI: 10.1016/j.conctc.2024.101366

Aim

The purpose of this secondary analysis was to describe issues related to internet connections during a virtual randomized clinical trial (v-RCT) that included family caregiver participants living in rural areas.

Background

Success of v-RCTs depends on reliable, high-quality internet access, which can be problematic in rural areas.

Methods

Interventionists documented connectivity issues and corrections made to address connectivity in a narrative note after each virtual visit with family caregivers enrolled in a v-RCT. Notes were reviewed for descriptions of the internet connection during the visit and then coded into those with and without connectivity problems. Two investigators reviewed notes and codes to assure reliability. Discrepancies in codes were discussed or arbitrated by a third investigator until consensus was reached. Analysis was completed using descriptive statistics.

Results

Of the 1003 visits reviewed, only 11 % of visits (115/1003) contained a documented problem with internet connectivity. Visits with documented connectivity problems were experienced by 27 % of participants (58/215). However, 60 % (35/58) of participants with a documented issue had a problem with only one visit. None of the participants withdrew from the v-RCT due to problems with their internet connections.

Conclusions

The findings support the effective use of virtual visits in research involving participants living in rural locations. V-RCTs provide a strategy that enables participation for individuals who may not otherwise have access to clinical trials conducted in-person in urban settings. Utilizing internet access to connect with and support people who live in rural areas is critically needed to advance clinical research.

背景v-RCT的成功取决于可靠、高质量的互联网接入,而这在农村地区可能存在问题。方法干预者在每次对参加v-RCT的家庭照顾者进行虚拟访问后,都会在叙述性笔记中记录连接问题以及为解决连接问题而采取的纠正措施。研究人员审查了笔记中关于访问期间网络连接的描述,然后将其编码为有连接问题和无连接问题。两名调查人员审查了笔记和编码,以确保可靠性。代码中的差异由第三位调查员进行讨论或仲裁,直至达成共识。结果 在审查的 1003 次就诊中,只有 11% 的就诊(115/1003)记录了互联网连接问题。27%的参与者(58/215)在就诊时遇到了记录在案的连接问题。然而,60%(35/58)的记录在案的参与者只在一次访问中遇到问题。没有一位参与者因网络连接问题退出虚拟研究。V-RCT提供了一种策略,使那些在城市环境中无法亲自参加临床试验的人也能参与其中。利用互联网连接和支持生活在农村地区的人们是推进临床研究的迫切需要。
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引用次数: 0
Protocol for a personalized (N-of-1) trial for testing the effects of a mind–body intervention on sleep duration in middle-aged women working in health care 测试身心干预对从事医疗保健工作的中年女性睡眠时间影响的个性化(N-of-1)试验方案
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-10 DOI: 10.1016/j.conctc.2024.101364

Background

Adequate sleep plays a crucial role in maintaining physical, mental, and emotional health. On average, adults require 7–9 h of sleep per night. However, less than two-thirds of women meet this recommendation. During the coronavirus disease 2019 (COVID-19) pandemic, poor sleep quality and moderate-to-severe stress were highly prevalent among healthcare workers (HCWs), especially women. While some interventions have been proposed to address stress/burnout in HCWs, few have focused specifically on women in healthcare. Therefore, this is a protocol for a study that aims to determine the efficacy of a mind–body intervention (MBI) to improve sleep duration among women HCWs aged 40–60 years using the personalized (N-of-1) trial design.

Methods

A personalized (N-of-1) trials model will be employed to evaluate the efficacy of an MBI to improve sleep duration (primary endpoint) and explore its effects on sleep quality, physiological factors, and their relationships with participants’ perceived stress, anxiety, and depression. The series of personalized trials (n = 60) will be conducted over 16 weeks. The MBI will include mindfulness, yoga, and guided walking, delivered in two 2-week block sequences for 12 weeks, with two 2-week periods for baseline and follow-up. Participants will watch 30-min videos three times weekly and wear an activity tracker to monitor sleep and activity. They will receive daily text messages with questions about sleep quality and bi-weekly questionnaires about their stress, anxiety and depression scores, fatigue, concentration, confidence, mood, and pain levels.

Conclusion

Results from this study will inform the development of N-of-1 methodology for addressing the health and wellness needs of middle-aged women.

背景充足的睡眠对保持身体、精神和情绪健康起着至关重要的作用。成年人平均每晚需要 7-9 小时的睡眠时间。然而,只有不到三分之二的女性符合这一建议。在 2019 年冠状病毒病(COVID-19)大流行期间,医护人员(尤其是女性)普遍存在睡眠质量差和中度至重度压力的问题。虽然已经提出了一些干预措施来解决医护人员的压力/倦怠问题,但很少有干预措施专门针对医护人员中的女性。因此,本研究旨在采用个性化(N-of-1)试验设计,确定身心干预(MBI)对改善 40-60 岁女性医护人员睡眠时间的疗效。方法将采用个性化(N-of-1)试验模式,评估 MBI 对改善睡眠时间(主要终点)的疗效,并探讨其对睡眠质量、生理因素的影响,以及它们与参与者感知到的压力、焦虑和抑郁之间的关系。一系列个性化试验(n = 60)将持续 16 周。MBI 将包括正念、瑜伽和引导步行,分两个 2 周的区块序列进行,为期 12 周,基线和随访分两个 2 周进行。参与者将每周观看三次 30 分钟的视频,并佩戴活动追踪器来监测睡眠和活动情况。她们每天都会收到有关睡眠质量问题的短信,每两周会收到有关压力、焦虑和抑郁评分、疲劳、注意力、信心、情绪和疼痛程度的问卷。
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引用次数: 0
Prevention of postpartum methamphetamine use with micronized progesterone trial (PROMPT): A pilot randomized controlled trial protocol 用微粒化黄体酮预防产后吸食甲基苯丙胺试验(PROMPT):随机对照试验试点方案
IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-30 DOI: 10.1016/j.conctc.2024.101359

Background

While most pregnant individuals with methamphetamine use disorder (MUD) achieve abstinence, the postpartum period remains a vulnerable time for return to methamphetamine use (MU). Promising data from human and animal models, including three randomized controlled trials, suggest that micronized progesterone may prevent postpartum return to cocaine and nicotine use by reducing cravings. The primary objective of this study is to assess feasibility of enrollment and randomization of postpartum individuals with MUD to micronized progesterone to prevent return to MU. The secondary objectives are to evaluate safety, establish a preliminary estimate of efficacy, and characterize the association between allopregnanolone levels and methamphetamine cravings.

Methods

This is a pilot double-blind placebo randomized controlled trial. We plan to enroll 40 postpartum individuals with MUD over 24-months. Individuals, stratified by opioid use disorder (OUD), are randomized 1:1–400 mg oral micronized progesterone daily or placebo and attend weekly study sessions for 12 weeks. Feasibility is measured by achieving 80 % of enrollment goal. Safety is evaluated by side effect frequency, mental health status changes, lactation and medical complications. Efficacy is assessed by comparing proportion of participants with return to MU and time to return to MU based on self-report or urine testing between treatment and control groups. Salivary allopregnanolone levels and methamphetamine cravings are compared between the groups.

Conclusion

Study results will provide a first critical step towards potential intervention for prevention of return to MU among postpartum individuals. Completion of this trial will set the stage for a large-scale efficacy trial.

背景虽然大多数患有甲基苯丙胺使用障碍(MUD)的孕妇都能实现戒毒,但产后仍是重新使用甲基苯丙胺(MU)的脆弱时期。来自人类和动物模型(包括三项随机对照试验)的有希望的数据表明,微粒化黄体酮可以通过减少渴求来防止产后再次吸食可卡因和尼古丁。本研究的主要目的是评估对患有 MUD 的产后患者进行注册和随机分配微粒化黄体酮以防止其重返 MU 的可行性。次要目标是评估安全性,初步估计疗效,并确定异丙孕酮水平与甲基苯丙胺渴求之间的关系。我们计划在 24 个月内招募 40 名患有 MUD 的产后患者。根据阿片类药物使用障碍(OUD)对患者进行分层,按 1:1-400 mg 每日口服微粒化黄体酮或安慰剂进行随机分配,并在 12 周内每周参加一次研究课程。可行性通过达到 80% 的注册目标来衡量。安全性通过副作用频率、精神健康状况变化、哺乳和医疗并发症进行评估。疗效通过比较治疗组和对照组中根据自我报告或尿液检测恢复 MU 的参与者比例和恢复 MU 的时间进行评估。结论:研究结果将为预防产后妇女复吸 MU 的潜在干预措施迈出关键的第一步。本试验的完成将为大规模疗效试验奠定基础。
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引用次数: 0
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Contemporary Clinical Trials Communications
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