8세부터 17세까지 4회의 세균성 뇌수막염을 경험하였던 21세 남자에서 세균성 뇌수막염이 재발하였고, 혈액과 뇌척수액에서 group B streptococcus (GBS)가 배양되었다. GBS에 의한 성인 뇌수막염의 사례는 흔하지 않으며, 본 증례 환자의 경우에도 과거 소아청소년시기에 재발했던 뇌수막염의 원인은 Streptococcus pneumoniae였다. 저자들은 세균성 뇌수막염이 재발하는 원인 중 환자의 면역 결핍 여부에 대해서는 검사를 통해 배제하였고, 기존의 여러 연구결과에 비추어보아 첫 발병 시부터 존재했던 두개저 해부학적 이상이 S. pneumoniae에 의한 뇌수막염 재발의 원인이라고 판단하였다. 나아가 성인이 되어 GBS 뇌수막염이 발병한 이유는 GBS 혈청형에 대한 옵소닌 포식항체의 혈청학적 유병률을 조사한 연구에 비추어보아 증례 환자가 GBS Ib에 대한 항체가 음성인 경우라면, 해부학적 결함이 해결되지 않은 상태가 코인두 보균이 침습 감염을 일으킬 수 있는 경로가 되어 발병한 사례라고 생각하였다. 환자는 3주 간 항생제 치료 후 임상 경과가 호전되어 퇴원 후 다른 병원에서 수막종과 동반된 뇌기저부의 뇌척수액 누출을 확진 받고 수술을 받았다. 환자는 앞으로도 세균성 뇌수막염 재발 여부와 후유증으로 치료받고 있는 뇌전증에 대해 지속적인 추적관찰이 필요하다.
一名21岁男子在8岁至17岁期间经历了4次细菌性脑膜炎，他又复发了细菌性脑膜炎，并在血液和脑脊液中培养了group B streptococcus (GBS)。由GBS引起的成人脑膜炎的事例并不多见，以本病例患者为例，过去小儿、青少年时期复发的脑膜炎的原因是Streptococcus pneumoniae。作者们细菌性脑膜炎复发的原因中,病人的免疫缺乏对是否通过检查排除的,根据现有的各研究结果,初次发病时至曾存在两个我s . pneumoniae解剖学异常引起的脑膜炎导致复发的原因的判断。乃至成人馆,脑膜炎发病的原因是馆,血清型来牛而是捕食抗体的血清对学籍发病率进行了调查研究,根据症患者馆,如ib对抗体阴性,如果不解决了解剖学的缺陷就是状态鼻咽病毒携带者可以侵袭引起感染的途径成为发病的事例认为。患者在接受了3周的抗生素治疗之后，临床经过有所好转，出院后到其他医院被确诊为脑膜瘤和脑基底的脑脊髓液泄漏，并接受了手术。患者今后也有必要对细菌性脑膜炎复发与否和因后遗症正在接受治疗的脑电症持续进行追踪观察。
{"title":"두개저 이상을 동반한 재발성 세균성 뇌수막염 증례보고","authors":"오 정민, 이 지연, 임 희정, 조 현혜, 김 경효","doi":"10.14776/PIV.2020.27.E4","DOIUrl":"https://doi.org/10.14776/PIV.2020.27.E4","url":null,"abstract":"8세부터 17세까지 4회의 세균성 뇌수막염을 경험하였던 21세 남자에서 세균성 뇌수막염이 재발하였고, 혈액과 뇌척수액에서 group B streptococcus (GBS)가 배양되었다. GBS에 의한 성인 뇌수막염의 사례는 흔하지 않으며, 본 증례 환자의 경우에도 과거 소아청소년시기에 재발했던 뇌수막염의 원인은 Streptococcus pneumoniae였다. 저자들은 세균성 뇌수막염이 재발하는 원인 중 환자의 면역 결핍 여부에 대해서는 검사를 통해 배제하였고, 기존의 여러 연구결과에 비추어보아 첫 발병 시부터 존재했던 두개저 해부학적 이상이 S. pneumoniae에 의한 뇌수막염 재발의 원인이라고 판단하였다. 나아가 성인이 되어 GBS 뇌수막염이 발병한 이유는 GBS 혈청형에 대한 옵소닌 포식항체의 혈청학적 유병률을 조사한 연구에 비추어보아 증례 환자가 GBS Ib에 대한 항체가 음성인 경우라면, 해부학적 결함이 해결되지 않은 상태가 코인두 보균이 침습 감염을 일으킬 수 있는 경로가 되어 발병한 사례라고 생각하였다. 환자는 3주 간 항생제 치료 후 임상 경과가 호전되어 퇴원 후 다른 병원에서 수막종과 동반된 뇌기저부의 뇌척수액 누출을 확진 받고 수술을 받았다. 환자는 앞으로도 세균성 뇌수막염 재발 여부와 후유증으로 치료받고 있는 뇌전증에 대해 지속적인 추적관찰이 필요하다.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75495794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute bacterial sinusitis is one of the most common diseases in children, and 5–13% of patients with viral upper respiratory infection experience secondary bacterial sinusitis as a complication. Isolated sphenoid sinusitis is rarer than frontal, maxillary, and ethmoid sinusitis. However, it presents potentially devastating complications, such as cranial nerve involvement, brain abscess, and meningitis, owing to its anatomical location. Nontypeable Haemophilus influenzae (NTHi) commonly causes acute bacterial sinusitis but rarely causes bacteremia, particularly in immunocompetent patients. We present a rare case of a 14-year-old boy with bacteremia due to isolated sphenoid sinusitis caused by NTHi.
{"title":"Isolated Sphenoid Sinusitis with Nontypeable Haemophilus influenzae Bacteremia in a Healthy Child","authors":"M. Seok, K. Choi, Saeam Shin, K. Cho","doi":"10.14776/piv.2020.27.e2","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e2","url":null,"abstract":"Acute bacterial sinusitis is one of the most common diseases in children, and 5–13% of patients with viral upper respiratory infection experience secondary bacterial sinusitis as a complication. Isolated sphenoid sinusitis is rarer than frontal, maxillary, and ethmoid sinusitis. However, it presents potentially devastating complications, such as cranial nerve involvement, brain abscess, and meningitis, owing to its anatomical location. Nontypeable Haemophilus influenzae (NTHi) commonly causes acute bacterial sinusitis but rarely causes bacteremia, particularly in immunocompetent patients. We present a rare case of a 14-year-old boy with bacteremia due to isolated sphenoid sinusitis caused by NTHi.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66642013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Brain Abscess due to Parvimonas micra in a Healthy Child without Dental Disease","authors":"Shin Young Lee, T. Roh, H. Jung","doi":"10.14776/piv.2020.27.e6","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e6","url":null,"abstract":"","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66642095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.14776/piv.2020.27.e11
Ki Hwan Kim, E. Cho, Dong Hyun Kim, H. Kim, J. Park, B. Eun, D. Jo, Soo-Han Choi, Jae Hong Choi, M. Han, E. Choi, Jong-Hyun Kim
The Korean Society of Pediatric Infectious Diseases and the Korea Centers for Disease Control and Prevention issued the guidelines about coronavirus disease 2019 (COVID-19) for children and adolescents. Case definitions and management of COVID-19 in neonates, infants, children and adolescents are presented in this guideline. In addition, guidelines for caregiver management are also provided. In this review, we introduce the contents of the current guidelines for COVID-19 in children and adolescents in Korea.
{"title":"Guidelines for Coronavirus Disease 2019 Response in Children and Adolescents","authors":"Ki Hwan Kim, E. Cho, Dong Hyun Kim, H. Kim, J. Park, B. Eun, D. Jo, Soo-Han Choi, Jae Hong Choi, M. Han, E. Choi, Jong-Hyun Kim","doi":"10.14776/piv.2020.27.e11","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e11","url":null,"abstract":"The Korean Society of Pediatric Infectious Diseases and the Korea Centers for Disease Control and Prevention issued the guidelines about coronavirus disease 2019 (COVID-19) for children and adolescents. Case definitions and management of COVID-19 in neonates, infants, children and adolescents are presented in this guideline. In addition, guidelines for caregiver management are also provided. In this review, we introduce the contents of the current guidelines for COVID-19 in children and adolescents in Korea.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66641919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology, Virology, and Clinical Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; Coronavirus Disease-19)","authors":"Su Eun Park","doi":"10.14776/piv.2020.27.e9","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e9","url":null,"abstract":"","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66642192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ascariasis is the most common helminthic infection in humans. However, its prevalence has been very low in Korea since the 1990s. Recently, there have been several case reports on intestinal obstruction or pancreaticobiliary disease due to infection with Ascaris lumbricoides in adults. However, cases of ascariasis in children have rarely been reported in Korea. We report a case of ascariasis in a 2-year-old boy who experienced expulsion of an adult ascaris worm from his anus. His mother found the worm in his diaper in the morning. His medical history was nonsignificant for any previous illnesses. There were no specific symptoms, and no abnormal findings were found on physical examination. The worm was pink, elongated, and cylindrical; it was 25 cm long and 5 mm wide. Unfertilized eggs of A. lumbricoides were detected in his stool specimen. He was treated with albendazole and remained asymptomatic at follow-up. As long as the number of immigrants from endemic areas and people returning from overseas trips, and import of agricultural products keep increasing, ascariasis can still occur in Korea. Therefore, it is necessary to raise awareness regarding ascariasis.
{"title":"A Case of Expulsion of an Adult Ascaris Worm from the Anus of a 2-year-old Boy","authors":"Y. Cho, Sik Kyung Choi, S. Kim","doi":"10.14776/piv.2020.27.e1","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e1","url":null,"abstract":"Ascariasis is the most common helminthic infection in humans. However, its prevalence has been very low in Korea since the 1990s. Recently, there have been several case reports on intestinal obstruction or pancreaticobiliary disease due to infection with Ascaris lumbricoides in adults. However, cases of ascariasis in children have rarely been reported in Korea. We report a case of ascariasis in a 2-year-old boy who experienced expulsion of an adult ascaris worm from his anus. His mother found the worm in his diaper in the morning. His medical history was nonsignificant for any previous illnesses. There were no specific symptoms, and no abnormal findings were found on physical examination. The worm was pink, elongated, and cylindrical; it was 25 cm long and 5 mm wide. Unfertilized eggs of A. lumbricoides were detected in his stool specimen. He was treated with albendazole and remained asymptomatic at follow-up. As long as the number of immigrants from endemic areas and people returning from overseas trips, and import of agricultural products keep increasing, ascariasis can still occur in Korea. Therefore, it is necessary to raise awareness regarding ascariasis.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66641858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.14776/piv.2020.27.e16
Jae Min Lee, Joon-sik Choi, K. Yoo, Yae-Jean Kim, Sun-Ja Kim
Staphylococcus epidermidis is a part of the normal skin flora of humans. However, it can cause serious infections in people exposed to foreign bodies or in immunocompromised patients. A 13-year-old boy was hospitalized with fever and myalgia. Painful nodular lesions were detected on the scalp, arms, and legs. Pancytopenia and blasts were present in the peripheral blood. He was diagnosed with acute myeloid leukemia. Magnetic resonance imaging of the whole body showed multiple peripheral rim-enhancing, cyst-like lesions. Ultrasonography showed echogenic nodules inside the cystic lesions in the intramuscular space of the arms and legs. Therefore, cysticercosis was strongly suggested initially. However, an abscess was confirmed on sono-guided biopsy and S. epidermidis was isolated from a microbial culture of the tissue. We report a case of multiple disseminated lesions caused by S. epidermidis in a leukemia patient, initially mistaken for cysticercosis.
{"title":"Disseminated Septic Lesions Caused by Staphylococcus epidermidis Mimicking Cysticercosis Detected on Ultrasonography in a Pediatric Patient with Acute Myeloid Leukemia","authors":"Jae Min Lee, Joon-sik Choi, K. Yoo, Yae-Jean Kim, Sun-Ja Kim","doi":"10.14776/piv.2020.27.e16","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e16","url":null,"abstract":"Staphylococcus epidermidis is a part of the normal skin flora of humans. However, it can cause serious infections in people exposed to foreign bodies or in immunocompromised patients. A 13-year-old boy was hospitalized with fever and myalgia. Painful nodular lesions were detected on the scalp, arms, and legs. Pancytopenia and blasts were present in the peripheral blood. He was diagnosed with acute myeloid leukemia. Magnetic resonance imaging of the whole body showed multiple peripheral rim-enhancing, cyst-like lesions. Ultrasonography showed echogenic nodules inside the cystic lesions in the intramuscular space of the arms and legs. Therefore, cysticercosis was strongly suggested initially. However, an abscess was confirmed on sono-guided biopsy and S. epidermidis was isolated from a microbial culture of the tissue. We report a case of multiple disseminated lesions caused by S. epidermidis in a leukemia patient, initially mistaken for cysticercosis.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66641969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dengue fever (DF) is endemic throughout tropical and subtropical regions; however, it is not endemic in Korea. Imported infectious diseases should be suspected when encountering returned travelers with non-specific symptoms such as fever, rash, and headache. Persistent vomiting, abdominal pain, hemorrhagic tendency, hepatic enzyme abnormalities, and proteinuria are risk factors for the development of severe DF in a patient with DF. Severe hyperglycemia is also known to be related to poor prognosis in acute illness, and with certain underlying diseases that present with hyperglycemia, such as diabetes, it is related to the progression of severe DF. We report a DF case with severe hyperglycemia in an adolescent returning from India. Pediatric DF cases reported in Korea were also reviewed.
{"title":"A Pediatric Case of Dengue Fever with Extreme Hyperglycemia Developed in a Family Who Returned from India","authors":"J. Kim, H. Kim","doi":"10.14776/piv.2020.27.e8","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e8","url":null,"abstract":"Dengue fever (DF) is endemic throughout tropical and subtropical regions; however, it is not endemic in Korea. Imported infectious diseases should be suspected when encountering returned travelers with non-specific symptoms such as fever, rash, and headache. Persistent vomiting, abdominal pain, hemorrhagic tendency, hepatic enzyme abnormalities, and proteinuria are risk factors for the development of severe DF in a patient with DF. Severe hyperglycemia is also known to be related to poor prognosis in acute illness, and with certain underlying diseases that present with hyperglycemia, such as diabetes, it is related to the progression of severe DF. We report a DF case with severe hyperglycemia in an adolescent returning from India. Pediatric DF cases reported in Korea were also reviewed.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66642142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.14776/piv.2020.27.e22
E. Yu, W. Kim, Young Jin Kim
Korea was verified as a measles-free country by the World Health Organization in 2014; however, some imported measles cases and related outbreaks were reported. As the incidence of wild-type measles decreases in measles-free countries, the proportion of vaccine-associated measles is increasing. Wild-type measles is highly contagious and requires follow-up and management of the contacts, whereas vaccine-related measles is not contagious and does not require follow-up intervention. Therefore, measles genotyping should be performed to reliably distinguish between them in suspected patients. Two patients with vaccine-associated measles were confirmed through genotyping at Daegu Fatima Hospital. In Korea, there are only a few reports of vaccine-associated measles confirmed through genotyping; thus, we report recent vaccine-associated measles cases, emphasizing the need for genotyping.
{"title":"Two Cases of Vaccine-Associated Measles in Daegu, South Korea, 2019","authors":"E. Yu, W. Kim, Young Jin Kim","doi":"10.14776/piv.2020.27.e22","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e22","url":null,"abstract":"Korea was verified as a measles-free country by the World Health Organization in 2014; however, some imported measles cases and related outbreaks were reported. As the incidence of wild-type measles decreases in measles-free countries, the proportion of vaccine-associated measles is increasing. Wild-type measles is highly contagious and requires follow-up and management of the contacts, whereas vaccine-related measles is not contagious and does not require follow-up intervention. Therefore, measles genotyping should be performed to reliably distinguish between them in suspected patients. Two patients with vaccine-associated measles were confirmed through genotyping at Daegu Fatima Hospital. In Korea, there are only a few reports of vaccine-associated measles confirmed through genotyping; thus, we report recent vaccine-associated measles cases, emphasizing the need for genotyping.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66642025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.14776/piv.2020.27.e15
Dongsub Kim
Purpose: Group A streptococcus (GAS) is a common pathogen in pediatric patients and often causes acute pharyngotonsillitis and skin and soft tissue infections. In addition, bacteremia with significant morbidity and mortality can also occur. This study was conducted to describe the clinical manifestations and treatment outcomes of pediatric GAS bacteremia patients in Korea. Methods: This was a single-center, retrospective study. From January 2000 to December 2016, pediatric patients aged ≤18 years with GAS bacteremia were studied. Clinical manifestations, underlying diseases, intensive care unit stay, and antibiotic susceptibility were evaluated. Results: During the study period, 19 patients had GAS bacteremia. Ten (53%) were male, and the median age was 7.4 years (range, 0.3–17.4 years). Fourteen (74%) had chronic underlying diseases. Five (26%) were immunocompromised (leukemia and chronic kidney disease). Eight (42%) had lymphatic or vascular malformations, of which seven had lesions with signs of inflammation. Three (16%) developed pneumonia, and two of them received ventilator care. The 30-day mortality rate was 6% (1/19), and the cause of death was bacteremic pneumonia. All GAS isolates were sensitive to penicillin. Fifteen (79%) were sensitive to both erythromycin and clindamycin. Conclusions: This study identified various clinical manifestations of GAS bacteremia. GAS should be considered as a potential pathogen that can cause bacteremia and result in a serious clinical course.
{"title":"Group A Streptococcal Bacteremia in Pediatric Patients: A Single-Center Study","authors":"Dongsub Kim","doi":"10.14776/piv.2020.27.e15","DOIUrl":"https://doi.org/10.14776/piv.2020.27.e15","url":null,"abstract":"Purpose: Group A streptococcus (GAS) is a common pathogen in pediatric patients and often causes acute pharyngotonsillitis and skin and soft tissue infections. In addition, bacteremia with significant morbidity and mortality can also occur. This study was conducted to describe the clinical manifestations and treatment outcomes of pediatric GAS bacteremia patients in Korea. Methods: This was a single-center, retrospective study. From January 2000 to December 2016, pediatric patients aged ≤18 years with GAS bacteremia were studied. Clinical manifestations, underlying diseases, intensive care unit stay, and antibiotic susceptibility were evaluated. Results: During the study period, 19 patients had GAS bacteremia. Ten (53%) were male, and the median age was 7.4 years (range, 0.3–17.4 years). Fourteen (74%) had chronic underlying diseases. Five (26%) were immunocompromised (leukemia and chronic kidney disease). Eight (42%) had lymphatic or vascular malformations, of which seven had lesions with signs of inflammation. Three (16%) developed pneumonia, and two of them received ventilator care. The 30-day mortality rate was 6% (1/19), and the cause of death was bacteremic pneumonia. All GAS isolates were sensitive to penicillin. Fifteen (79%) were sensitive to both erythromycin and clindamycin. Conclusions: This study identified various clinical manifestations of GAS bacteremia. GAS should be considered as a potential pathogen that can cause bacteremia and result in a serious clinical course.","PeriodicalId":37997,"journal":{"name":"Pediatric Infection and Vaccine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66641934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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