Pub Date : 2024-05-08DOI: 10.1007/s13272-024-00737-7
F. Möhren, O. Bergmann, F. Janser, C. Braun
{"title":"Assessment of structural mechanical effects related to torsional deformations of propellers","authors":"F. Möhren, O. Bergmann, F. Janser, C. Braun","doi":"10.1007/s13272-024-00737-7","DOIUrl":"https://doi.org/10.1007/s13272-024-00737-7","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.1007/s13272-024-00739-5
T. Dehne, P. Lange, D. Schmeling, Ingo Gores
{"title":"Experimental evaluation of alternative ceiling-based ventilation systems for long-range passenger aircraft","authors":"T. Dehne, P. Lange, D. Schmeling, Ingo Gores","doi":"10.1007/s13272-024-00739-5","DOIUrl":"https://doi.org/10.1007/s13272-024-00739-5","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141020877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.1007/s13272-023-00708-4
Jan Berling, Alexander Lau, Volker Gollnick
{"title":"Constraint reconciliation optimization to minimize primary and reactionary delay in a research network strategic tool","authors":"Jan Berling, Alexander Lau, Volker Gollnick","doi":"10.1007/s13272-023-00708-4","DOIUrl":"https://doi.org/10.1007/s13272-023-00708-4","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"20 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-22DOI: 10.1007/s13272-024-00736-8
T. Bielsky, Nils Kuelper, Frank Thielecke
{"title":"Assessment of an auto-routing method for topology generation of aircraft power supply systems","authors":"T. Bielsky, Nils Kuelper, Frank Thielecke","doi":"10.1007/s13272-024-00736-8","DOIUrl":"https://doi.org/10.1007/s13272-024-00736-8","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"71 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140677518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1007/s13272-024-00738-6
Dennis Becker, L. Schalk
{"title":"Toward robust and efficient communications for urban air mobility","authors":"Dennis Becker, L. Schalk","doi":"10.1007/s13272-024-00738-6","DOIUrl":"https://doi.org/10.1007/s13272-024-00738-6","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1007/s13272-024-00722-0
A. Vinz, A. Raichle
{"title":"Investigation of the effects of boundary layer ingestion engine integration on aircraft thrust requirement","authors":"A. Vinz, A. Raichle","doi":"10.1007/s13272-024-00722-0","DOIUrl":"https://doi.org/10.1007/s13272-024-00722-0","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"21 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1007/s13272-024-00732-y
I. Metz, S. Schier-Morgenthal
{"title":"Extending air traffic control tasks to control air taxis and to warn of critical wildlife: an impact analysis","authors":"I. Metz, S. Schier-Morgenthal","doi":"10.1007/s13272-024-00732-y","DOIUrl":"https://doi.org/10.1007/s13272-024-00732-y","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"12 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1101/2023.02.07.527394
Ketaki A Katdare, Andrew Kjar, Natasha M O'Brown, Emma H Neal, Alexander G Sorets, Alena Shostak, Wilber Romero-Fernandez, Alexander J Kwiatkowski, Kate Mlouk, Hyosung Kim, Rebecca P Cowell, Katrina R Schwensen, Kensley B Horner, John T Wilson, Matthew S Schrag, Sean G Megason, Ethan S Lippmann
Brain endothelial cells (BECs) play an important role in maintaining central nervous system (CNS) homeostasis through blood-brain barrier (BBB) functions. BECs express low baseline levels of adhesion receptors, which limits entry of leukocytes. However, the molecular mediators governing this phenotype remain mostly unclear. Here, we explored how infiltration of immune cells across the BBB is influenced by the scaffold protein IQ motif containing GTPase activating protein 2 (IQGAP2). In mice and zebrafish, we demonstrate that loss of Iqgap2 increases infiltration of peripheral leukocytes into the CNS under homeostatic and inflammatory conditions. Using single-cell RNA sequencing and immunohistology, we further show that BECs from mice lacking Iqgap2 exhibit a profound inflammatory signature, including extensive upregulation of adhesion receptors and antigen-processing machinery. Human tissue analyses also reveal that Alzheimer's disease is associated with reduced hippocampal IQGAP2. Overall, our results implicate IQGAP2 as an essential regulator of BBB immune privilege and immune cell entry into the CNS.
{"title":"IQGAP2 regulates blood-brain barrier immune dynamics.","authors":"Ketaki A Katdare, Andrew Kjar, Natasha M O'Brown, Emma H Neal, Alexander G Sorets, Alena Shostak, Wilber Romero-Fernandez, Alexander J Kwiatkowski, Kate Mlouk, Hyosung Kim, Rebecca P Cowell, Katrina R Schwensen, Kensley B Horner, John T Wilson, Matthew S Schrag, Sean G Megason, Ethan S Lippmann","doi":"10.1101/2023.02.07.527394","DOIUrl":"10.1101/2023.02.07.527394","url":null,"abstract":"<p><p>Brain endothelial cells (BECs) play an important role in maintaining central nervous system (CNS) homeostasis through blood-brain barrier (BBB) functions. BECs express low baseline levels of adhesion receptors, which limits entry of leukocytes. However, the molecular mediators governing this phenotype remain mostly unclear. Here, we explored how infiltration of immune cells across the BBB is influenced by the scaffold protein IQ motif containing GTPase activating protein 2 (IQGAP2). In mice and zebrafish, we demonstrate that loss of Iqgap2 increases infiltration of peripheral leukocytes into the CNS under homeostatic and inflammatory conditions. Using single-cell RNA sequencing and immunohistology, we further show that BECs from mice lacking Iqgap2 exhibit a profound inflammatory signature, including extensive upregulation of adhesion receptors and antigen-processing machinery. Human tissue analyses also reveal that Alzheimer's disease is associated with reduced hippocampal IQGAP2. Overall, our results implicate IQGAP2 as an essential regulator of BBB immune privilege and immune cell entry into the CNS.</p>","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11030232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74558490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-08DOI: 10.1007/s13272-023-00712-8
M. Seidler, Z. Montano, D. Mimic, N. Meinicke, J. Friedrichs, J. Riemenschneider, J. R. Seume
{"title":"Combining shape-adaptive blades and active flow control in a multi-stage axial compressor: a numerical study","authors":"M. Seidler, Z. Montano, D. Mimic, N. Meinicke, J. Friedrichs, J. Riemenschneider, J. R. Seume","doi":"10.1007/s13272-023-00712-8","DOIUrl":"https://doi.org/10.1007/s13272-023-00712-8","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"35 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1007/s13272-024-00731-z
B. G. van der Wall, Joon W. Lim, Johannes Riemenschneider, Steffen Kalow, Gunther A. Wilke, D. D. Boyd, J. Bailly, Y. Delrieux, Italo Cafarelli, Y. Tanabe, H. Sugawara, S. N. Jung, Seong H. Hong, Do-Hyung Kim, Hee J. Kang, G. Barakos, Rinaldo Steininger
{"title":"New smart twisting active rotor (STAR): pretest predictions","authors":"B. G. van der Wall, Joon W. Lim, Johannes Riemenschneider, Steffen Kalow, Gunther A. Wilke, D. D. Boyd, J. Bailly, Y. Delrieux, Italo Cafarelli, Y. Tanabe, H. Sugawara, S. N. Jung, Seong H. Hong, Do-Hyung Kim, Hee J. Kang, G. Barakos, Rinaldo Steininger","doi":"10.1007/s13272-024-00731-z","DOIUrl":"https://doi.org/10.1007/s13272-024-00731-z","url":null,"abstract":"","PeriodicalId":38083,"journal":{"name":"CEAS Aeronautical Journal","volume":"448 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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