K. Shelygin, T. Ushakova, N. V. Zykova, L. I. Lozhkina, Valentina A. Mikityuk
BACKGROUND:Currently, health care occupies an exceptional place in a socially oriented economy. To assess the effective functioning of the health care system, it is necessary to constantlymonitor performance indicators that allow you to determine the level of saving the health of the population. AIM:Determine the degree of effectiveness of health system management based on a comparative analysis of certain target indicators with their actual values. MATERIALS AND METHODS:An analysis of the indicators contained in the State program of the Arkhangelsk region "Health care development in the Arkhangelsk region" was carried out. The following parameters were chosen as targets: life expectancy at birth; maternal mortality per 1000 live births; infant mortality per 1000 live births; total fertility rate; number of doctors per 10000 population; number of average medical personnel per one doctor. Analysis period: 2010-2020. The study is retrospective, descriptive, not randomized. To calculate the private and integral indicators of regional management performance we used the method proposed by A.V. Pepelyaeva and E.A. Tretiakova. The analysis of dynamic series for the presence of anomalous values (outliers) was carried out by the Irwin method. RESULTS:The main indicators that ensure the level of performance are maternal mortality and availability of doctors. The availability of doctors per 10,000 population was significantly higher than the target indicators over the entire time period by an average of 32.8%. The target indicators of maternal mortality were lower than the actual ones on average by 50.1%, which seems to be due to overestimation of the target indicator. CONCLUSION:Target indicators of health care system performance tend to overestimate against the background of the lack of a clearly defined methodological apparatus for their calculation, which, in most cases, leads to a mismatch between their dynamics and the dynamics of actual indicators, increasing the calculated level of health care system management performance.
{"title":"PERFORMANCE OF MANAGEMENT OF THE HEALTH SYSTEM (ON THE EXAMPLE OF THE ARKHANGELSK REGION)","authors":"K. Shelygin, T. Ushakova, N. V. Zykova, L. I. Lozhkina, Valentina A. Mikityuk","doi":"10.17816/humeco121859","DOIUrl":"https://doi.org/10.17816/humeco121859","url":null,"abstract":"BACKGROUND:Currently, health care occupies an exceptional place in a socially oriented economy. To assess the effective functioning of the health care system, it is necessary to constantlymonitor performance indicators that allow you to determine the level of saving the health of the population. \u0000AIM:Determine the degree of effectiveness of health system management based on a comparative analysis of certain target indicators with their actual values. \u0000MATERIALS AND METHODS:An analysis of the indicators contained in the State program of the Arkhangelsk region \"Health care development in the Arkhangelsk region\" was carried out. The following parameters were chosen as targets: life expectancy at birth; maternal mortality per 1000 live births; infant mortality per 1000 live births; total fertility rate; number of doctors per 10000 population; number of average medical personnel per one doctor. Analysis period: 2010-2020. The study is retrospective, descriptive, not randomized. To calculate the private and integral indicators of regional management performance we used the method proposed by A.V. Pepelyaeva and E.A. Tretiakova. The analysis of dynamic series for the presence of anomalous values (outliers) was carried out by the Irwin method. \u0000RESULTS:The main indicators that ensure the level of performance are maternal mortality and availability of doctors. The availability of doctors per 10,000 population was significantly higher than the target indicators over the entire time period by an average of 32.8%. The target indicators of maternal mortality were lower than the actual ones on average by 50.1%, which seems to be due to overestimation of the target indicator. \u0000CONCLUSION:Target indicators of health care system performance tend to overestimate against the background of the lack of a clearly defined methodological apparatus for their calculation, which, in most cases, leads to a mismatch between their dynamics and the dynamics of actual indicators, increasing the calculated level of health care system management performance.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Ragozin, Pavel B Tatarinzev, A. Gudkov, I. Pogonysheva, Elena Yu. Shalamova, D. A. Pogonyshev, Anvar Beisembaev
Resume. The purpose of the study is to develop mathematical and geographical corrections in the analysis of time series. Materials and methods. The paper uses the results of a long-term analysis of the physiological and demographic indicators of the population of Khanty-Mansiysk and other regions of Russia. Results. For standardization and ranking of inter-seasonal, interregional studies (physiology of movements, shift work) in chronophysiological format, we propose the use of the calculated "photoperiodic latitudinal coefficient". To improve the accuracy of the results, we propose the use of the "signal noise coefficient" in the interpretation of the results, an assessment of the "degree of polyrhythmicity" and the "rhythm instability index" in the presence of "insertion" or "quantized" rhythms.
{"title":"Geographical and mathematical corrections in the analysis of time series in regions with a modified photoperiod","authors":"O. Ragozin, Pavel B Tatarinzev, A. Gudkov, I. Pogonysheva, Elena Yu. Shalamova, D. A. Pogonyshev, Anvar Beisembaev","doi":"10.17816/humeco117532","DOIUrl":"https://doi.org/10.17816/humeco117532","url":null,"abstract":"Resume. \u0000The purpose of the study is to develop mathematical and geographical corrections in the analysis of time series. \u0000Materials and methods. The paper uses the results of a long-term analysis of the physiological and demographic indicators of the population of Khanty-Mansiysk and other regions of Russia. \u0000Results. For standardization and ranking of inter-seasonal, interregional studies (physiology of movements, shift work) in chronophysiological format, we propose the use of the calculated \"photoperiodic latitudinal coefficient\". To improve the accuracy of the results, we propose the use of the \"signal noise coefficient\" in the interpretation of the results, an assessment of the \"degree of polyrhythmicity\" and the \"rhythm instability index\" in the presence of \"insertion\" or \"quantized\" rhythms.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89446193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Dobrodeeva, Samodova Samodova, S. N. Balashova, K. O. Pashinskaya
Introduction: Numerous studies have proven the relationship between the content of brain natriuretic peptide (BNP) in the blood and the problems of cardiovascular insufficiency.Aim: To study the role of changes in Nt-pro-BNP concentrations in the blood in the regulation of hemodynamic reactions in practically adults living and working in the Arctic. Materials and methods. 111 adults (46-55 years old) of practically healthy persons living and working on the Svalbard peninsula, as well as in the villages of Revda and Lovozero of the Murmansk region, including 66 women and 45 men, were examined. The comparison group included 118 healthy adults born and living in the Primorsky district of the Arkhangelsk region, 59 women and 59 men aged 46-55 years.The hemogram in peripheral venous blood, the content of lymphocytes with CD3, CD4, CD8, CD10, CD16, CD19, CD23, CD25, CD71 phenotypes were studied by indirect immunoperoxidase reaction (Sorbent, Moscow) and flow cytometry (Beckman Coulter Immunotech, France); concentrations of Nt-pro-BNP, endothelin-1, total NO, endogenous NO2, nitrate NO3 (RnDSystems, USA), cortisol, norepinephrine, epinephrine (Bender Medsystems, Austria) using enzyme immunoassay. The results are presented as the arithmetic mean and the error of the mean (Mm). For comparison between groups, an independent sample t-test or a nonparametric Mann-Whitney U-test was used, depending on the distribution.Results: In people living in the Arctic and territories equated to the regions of the Far North, the content of the precursor of natriuretic peptide in the venous peripheral blood is higher. Elevated concentrations of Nt-pro-BNP in the blood of Arctic residents are associated with simultaneously higher levels of norepinephrine and cortisol against the background of less pronounced concentrations of adrenaline and endothelin-1, as well as the redistribution of lymphocytes and monocytes from the circulating pool to the marginal one. The established features of hemodynamic reaction regulation are more pronounced in adult Arctic residents and women.Conclusion: The effect of natriuretic peptide is associated with simultaneous activation of the secretion of norepinephrine and cortisol and constitutes a risk of disruption of the mechanisms for maintaining the osmolarity of the internal environment of the body in a very narrow range.
{"title":"Changes in the concentrations of brain natriuretic peptide (Nt-pro-BNP) in the blood in the regulation of hemodynamic reactions in practically healthy people living in the Arctic","authors":"L. Dobrodeeva, Samodova Samodova, S. N. Balashova, K. O. Pashinskaya","doi":"10.17816/humeco120042","DOIUrl":"https://doi.org/10.17816/humeco120042","url":null,"abstract":"Introduction: Numerous studies have proven the relationship between the content of brain natriuretic peptide (BNP) in the blood and the problems of cardiovascular insufficiency.Aim: To study the role of changes in Nt-pro-BNP concentrations in the blood in the regulation of hemodynamic reactions in practically adults living and working in the Arctic. \u0000Materials and methods. 111 adults (46-55 years old) of practically healthy persons living and working on the Svalbard peninsula, as well as in the villages of Revda and Lovozero of the Murmansk region, including 66 women and 45 men, were examined. The comparison group included 118 healthy adults born and living in the Primorsky district of the Arkhangelsk region, 59 women and 59 men aged 46-55 years.The hemogram in peripheral venous blood, the content of lymphocytes with CD3, CD4, CD8, CD10, CD16, CD19, CD23, CD25, CD71 phenotypes were studied by indirect immunoperoxidase reaction (Sorbent, Moscow) and flow cytometry (Beckman Coulter Immunotech, France); concentrations of Nt-pro-BNP, endothelin-1, total NO, endogenous NO2, nitrate NO3 (RnDSystems, USA), cortisol, norepinephrine, epinephrine (Bender Medsystems, Austria) using enzyme immunoassay. The results are presented as the arithmetic mean and the error of the mean (Mm). For comparison between groups, an independent sample t-test or a nonparametric Mann-Whitney U-test was used, depending on the distribution.Results: In people living in the Arctic and territories equated to the regions of the Far North, the content of the precursor of natriuretic peptide in the venous peripheral blood is higher. Elevated concentrations of Nt-pro-BNP in the blood of Arctic residents are associated with simultaneously higher levels of norepinephrine and cortisol against the background of less pronounced concentrations of adrenaline and endothelin-1, as well as the redistribution of lymphocytes and monocytes from the circulating pool to the marginal one. The established features of hemodynamic reaction regulation are more pronounced in adult Arctic residents and women.Conclusion: The effect of natriuretic peptide is associated with simultaneous activation of the secretion of norepinephrine and cortisol and constitutes a risk of disruption of the mechanisms for maintaining the osmolarity of the internal environment of the body in a very narrow range.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80946399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Popovich, A. Kontsevaya, E. Oussova, V. Zinovyeva, M. Lopatina, O. Drapkina
Formation of a socially comfortable urban environment is of a great importance for reducing health risks of the living population. The results of many foreign studies, assessing urban infrastructure, indicate a significant impact of environmental elements: buildings, transport, street design, public spaces, as well as access to infrastructure resources such as healthy eating, recreation areas and places for physical activity on the health of the living population. In Russia, such research is being carried out for the first time, in this regard, it seems appropriate to introduce the research methodology for the audience. The purpose of this article is to describe the relevance, design of the study and the methodology for a comprehensive assessment of the actual state of the infrastructure of the municipality, affecting the health of the residing population and the analysis of the association of infrastructure with the lifestyle for the formation of a unified preventive environment at the level of the municipality and the development of a comprehensive intersectoral health promotion program, taking into account risk factors (RF) for health of population in a specific municipality territory.
{"title":"A MODEL FOR A COMPREHENSIVE ASSESSMENT OF THE ACTUAL STATE OF THE HEALTH- AFFECTING INFRASTRUCTURE OF THE MUNICIPALITY AND ANALYSIS OF THE ASSOCIATION OF INFRASTRUCTURE WITH THE LIFESTYLE OF THE POPULATION: RELENANCE, STUDY DESIGN AND METODOLOGY","authors":"M. Popovich, A. Kontsevaya, E. Oussova, V. Zinovyeva, M. Lopatina, O. Drapkina","doi":"10.17816/humeco76381","DOIUrl":"https://doi.org/10.17816/humeco76381","url":null,"abstract":"Formation of a socially comfortable urban environment is of a great importance for reducing health risks of the living population. The results of many foreign studies, assessing urban infrastructure, indicate a significant impact of environmental elements: buildings, transport, street design, public spaces, as well as access to infrastructure resources such as healthy eating, recreation areas and places for physical activity on the health of the living population. In Russia, such research is being carried out for the first time, in this regard, it seems appropriate to introduce the research methodology for the audience. \u0000The purpose of this article is to describe the relevance, design of the study and the methodology for a comprehensive assessment of the actual state of the infrastructure of the municipality, affecting the health of the residing population and the analysis of the association of infrastructure with the lifestyle for the formation of a unified preventive environment at the level of the municipality and the development of a comprehensive intersectoral health promotion program, taking into account risk factors (RF) for health of population in a specific municipality territory.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72728853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary. Introduction. The possibility of realizing the intellectual potential and development of students with enhanced abilities is actually ensured by creating conditions aimed at preserving and maintaining their health. Methods. In order to scientifically substantiate the system of accompanying students with increased mental abilities under the influence of risk factors of the educational environment on the basis of a multidisciplinary lyceum for gifted adolescents, a one-stage study of risk factors for the organization and intensity of the educational process and daily routine of students in grades 9-11 was carried out. To substantiate the application of the biofeedback method in the medical support system, the students were taught the diaphragmatic breathing technique, the effectiveness of which was evaluated on the basis of a comparative analysis of the functional state of the central nervous and cardiovascular systems, the psycho-emotional status of students before and after two weeks of functional biofeedback training. Results. It is shown that the risk factors for the health of students with increased mental abilities were the irrational organization of educational activities, its high intensity, as well as the violation of such health-saving components of the daily routine as night sleep and walks. At the same time, the analysis showed that the training loads contributed to the development of mental performance, and at the same time, increased tension in the regulatory systems of the students' body, which determined the need to develop a system to support students in the educational process. It was found that the implementation of diaphragmatic breathing training contributed to a 1.3-fold decrease in the level of anxiety among students, an increase in the number of students with satisfactory biological adaptation, against the background of a decrease in the number of students with reduced mental performance. Conclusion. The results of the study made it possible to scientifically substantiate and develop a system of accompanying students with enhanced abilities in the educational process, the implementation of which involves screening the diagnosis of the psychophysiological state of students, the formation of students of the "risk group" and "health group", the organization of a complex of corrective and health-improving and health-saving measures for them, aimed at increasing compensatory capabilities and psychophysiological reserves, strengthening and maintaining the health of students in the learning process.
{"title":"HYGIENIC JUSTIFICATION OF THE SYSTEM OF MEDICAL SUPPORT FOR STUDENTS WITH INCREASED MENTAL ABILITIES UNDER THE IMPACT OF EDUCATIONAL ENVIRONMENT RISK FACTORS","authors":"A. Setko, O. Zhdanova","doi":"10.17816/humeco106761","DOIUrl":"https://doi.org/10.17816/humeco106761","url":null,"abstract":"Summary. Introduction. The possibility of realizing the intellectual potential and development of students with enhanced abilities is actually ensured by creating conditions aimed at preserving and maintaining their health. Methods. In order to scientifically substantiate the system of accompanying students with increased mental abilities under the influence of risk factors of the educational environment on the basis of a multidisciplinary lyceum for gifted adolescents, a one-stage study of risk factors for the organization and intensity of the educational process and daily routine of students in grades 9-11 was carried out. To substantiate the application of the biofeedback method in the medical support system, the students were taught the diaphragmatic breathing technique, the effectiveness of which was evaluated on the basis of a comparative analysis of the functional state of the central nervous and cardiovascular systems, the psycho-emotional status of students before and after two weeks of functional biofeedback training. Results. It is shown that the risk factors for the health of students with increased mental abilities were the irrational organization of educational activities, its high intensity, as well as the violation of such health-saving components of the daily routine as night sleep and walks. At the same time, the analysis showed that the training loads contributed to the development of mental performance, and at the same time, increased tension in the regulatory systems of the students' body, which determined the need to develop a system to support students in the educational process. It was found that the implementation of diaphragmatic breathing training contributed to a 1.3-fold decrease in the level of anxiety among students, an increase in the number of students with satisfactory biological adaptation, against the background of a decrease in the number of students with reduced mental performance. Conclusion. The results of the study made it possible to scientifically substantiate and develop a system of accompanying students with enhanced abilities in the educational process, the implementation of which involves screening the diagnosis of the psychophysiological state of students, the formation of students of the \"risk group\" and \"health group\", the organization of a complex of corrective and health-improving and health-saving measures for them, aimed at increasing compensatory capabilities and psychophysiological reserves, strengthening and maintaining the health of students in the learning process.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80269200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: Observed global climate changes can significantly influence on the regional climate anomalies and recreational conditions over the Crimean peninsula. AIM: To study the features of complex bioclimatic indicators changes on the territory of Crimea over a multidecadal period (~70 years), paying special attention to each month of the year, and on bases of obtained results to show the possible way of recreational activities development associated with these changes. METHODS: For calculations, we used daily hydrometeorological data for each month from the archive of observations at the network of European weather stations E-OBS (v. 17.0) from 22 stations and NCEP/NCAR R1 reanalysis for the period of 19502018. The obtained arrays were verified in accordance with an open database of standard daily station observations in Crimea in 20052018. To assess the impact of climate change on the human body, the equivalent effective temperature, normal equivalent effective temperature, weight content of oxygen in the air (partial oxygen density) (O2), wet wind chill index Hill (Hw) and index Bodmann dry wind chiller (S) were calculated. The features of their linear trends for each month in the Crimean Peninsula were analysed. RESULTS: Monthwise analyses of the bioclimatic indicator trends demonstrated an increase or decrease in recreational comfort in certain seasons. The most pronounced positive normal equivalent effective temperature trends over Crimea were observed from winter to spring. This indicated improved complex recreational conditions in recent decades and the possibility to extend the duration of the holiday season. The pO2, Hw and S indices had opposite tendencies throughout the year (except for December). According to the pO2 index, in the period from August to October, a physiological oxygen deficiency may be experienced throughout Crimea. Windy and uncomfortable bioclimatic conditions tend to increase in the steppes of Crimea in December. CONCLUSION: The patterns of changes in bioclimatic indicators revealed through this study can be used as a regulatory factor for effectively organising and conducting recreational activities in the territory of Crimea and thus ensure the duration of the recreational period.
{"title":"Changes in complex bioclimatic indicators in Crimea since the middle of the 20th century","authors":"Anna A. Stefanovich, E. Voskresenskaya","doi":"10.17816/humeco111767","DOIUrl":"https://doi.org/10.17816/humeco111767","url":null,"abstract":"BACKGROUND: Observed global climate changes can significantly influence on the regional climate anomalies and recreational conditions over the Crimean peninsula. \u0000AIM: To study the features of complex bioclimatic indicators changes on the territory of Crimea over a multidecadal period (~70 years), paying special attention to each month of the year, and on bases of obtained results to show the possible way of recreational activities development associated with these changes. \u0000METHODS: For calculations, we used daily hydrometeorological data for each month from the archive of observations at the network of European weather stations E-OBS (v. 17.0) from 22 stations and NCEP/NCAR R1 reanalysis for the period of 19502018. The obtained arrays were verified in accordance with an open database of standard daily station observations in Crimea in 20052018. To assess the impact of climate change on the human body, the equivalent effective temperature, normal equivalent effective temperature, weight content of oxygen in the air (partial oxygen density) (O2), wet wind chill index Hill (Hw) and index Bodmann dry wind chiller (S) were calculated. The features of their linear trends for each month in the Crimean Peninsula were analysed. \u0000RESULTS: Monthwise analyses of the bioclimatic indicator trends demonstrated an increase or decrease in recreational comfort in certain seasons. The most pronounced positive normal equivalent effective temperature trends over Crimea were observed from winter to spring. This indicated improved complex recreational conditions in recent decades and the possibility to extend the duration of the holiday season. The pO2, Hw and S indices had opposite tendencies throughout the year (except for December). According to the pO2 index, in the period from August to October, a physiological oxygen deficiency may be experienced throughout Crimea. Windy and uncomfortable bioclimatic conditions tend to increase in the steppes of Crimea in December. \u0000CONCLUSION: The patterns of changes in bioclimatic indicators revealed through this study can be used as a regulatory factor for effectively organising and conducting recreational activities in the territory of Crimea and thus ensure the duration of the recreational period.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89332278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The association of hemoblastoses, tumours of the central nervous system, with several other human neoplasms with various environmental factors of a chemical and physical nature has been previously established. Nonetheless, the mechanism of this relationship remains unclear. The author formulated the concept of environmentally determined oncogenesis with a key role of heme. According to the proposed model, the first stage of oncogenesis is the induction of environmentally determined oxidative stress, which is amplified by haem iron. Simultaneously, due to the ferromagnetic properties of heme iron reception, the induction and amplification of external electromagnetic fields occur with the formation of a feedback loop and additional stimulation of oxidative processes. Further, under the influence of active oxygen metabolites in target tissues with the greatest contact with heme, epigenomic dysregulation of semaphorin is developed. This leads to oncogenesis in actively proliferating cells of the axon growth cone, bone marrow, precursors of kidney cells, mesenchymal stem cells and endothelium. Consequently, benign tumours of the endothelium (hemangiomas), leukemias, lymphomas, tumours of the peripheral and central nervous system, as well as benign and malignant tumours of soft tissues occur. The proposed model illustrates the features of childhood oncology incidence with a predominance of hemangiomas among benign tumours, as well as hemoblastoses and tumours of the nervous system among cancers. In addition, the ability of heme to interact with electromagnetic fields advances our understanding of the relationship between neoplasms and solar activity.
{"title":"The role of heme in environmentally caused oncogenesis (review)","authors":"S. K. Pinaev","doi":"10.17816/humeco115234","DOIUrl":"https://doi.org/10.17816/humeco115234","url":null,"abstract":"The association of hemoblastoses, tumours of the central nervous system, with several other human neoplasms with various environmental factors of a chemical and physical nature has been previously established. Nonetheless, the mechanism of this relationship remains unclear. The author formulated the concept of environmentally determined oncogenesis with a key role of heme. According to the proposed model, the first stage of oncogenesis is the induction of environmentally determined oxidative stress, which is amplified by haem iron. Simultaneously, due to the ferromagnetic properties of heme iron reception, the induction and amplification of external electromagnetic fields occur with the formation of a feedback loop and additional stimulation of oxidative processes. Further, under the influence of active oxygen metabolites in target tissues with the greatest contact with heme, epigenomic dysregulation of semaphorin is developed. This leads to oncogenesis in actively proliferating cells of the axon growth cone, bone marrow, precursors of kidney cells, mesenchymal stem cells and endothelium. Consequently, benign tumours of the endothelium (hemangiomas), leukemias, lymphomas, tumours of the peripheral and central nervous system, as well as benign and malignant tumours of soft tissues occur. The proposed model illustrates the features of childhood oncology incidence with a predominance of hemangiomas among benign tumours, as well as hemoblastoses and tumours of the nervous system among cancers. In addition, the ability of heme to interact with electromagnetic fields advances our understanding of the relationship between neoplasms and solar activity.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79369251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Firefighters are characterized by constant interaction with smoke and various combustion products, which, entering the body can, affect the state of the respiratory system. Objective: To study the relationship of the bioelemental status with changes in the functional state of the lungs in firefighters of the Ministry of Emergency Situations of Russia. Results: The study revealed an increase in a number of toxic microelements in firefighters by 2-5 times compared with persons not participating in fire extinguishing, as well as a decrease in the content of essential microelements in the studied hair samples. The connection of toxic trace elements (aluminum, silver, cadmium) with a decrease in the diffusion capacity of the lungs, broncho-obstructive changes and pulmonary fibrosis was shown. The study showed the relationship between the accumulation of the level of silver, aluminum and cadmium with noticeable changes in the functional state of the lungs.
{"title":"RELATIONSHIP OF BIOELEMENTAL STATUS AND CHANGES IN THE FUNCTIONAL STATE OF THE LUNGS IN THE FIRE FIGHTERS OF THE EMERCOM OF RUSSIA","authors":"M. Vlasenko, M. Sannikov","doi":"10.17816/humeco108708","DOIUrl":"https://doi.org/10.17816/humeco108708","url":null,"abstract":"Background: Firefighters are characterized by constant interaction with smoke and various combustion products, which, entering the body can, affect the state of the respiratory system. \u0000 Objective: To study the relationship of the bioelemental status with changes in the functional state of the lungs in firefighters of the Ministry of Emergency Situations of Russia. \u0000 Results: The study revealed an increase in a number of toxic microelements in firefighters by 2-5 times compared with persons not participating in fire extinguishing, as well as a decrease in the content of essential microelements in the studied hair samples. The connection of toxic trace elements (aluminum, silver, cadmium) with a decrease in the diffusion capacity of the lungs, broncho-obstructive changes and pulmonary fibrosis was shown. \u0000The study showed the relationship between the accumulation of the level of silver, aluminum and cadmium with noticeable changes in the functional state of the lungs.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72714598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Darenskaya, L. V. Rychkova, S. Kolesnikov, N. Semenova, L. Kolesnikova
Introduction: Integral parameters, in particular, the oxidative stress coefficient, created by Scientific Centre for Family Health and Human Reproduction Problems, are more informative in contrast to individual indicators and can be used both for evaluation of pathological conditions and compensatory-adaptive reactions of the organism. The general decrease of the adaptation possibilities in the female population, especially indigenous peoples as a part of the reproductive potential of the nation has been noted. The estimation of the integral coefficient in adolescent girls living in different territories and belonging to different ethnic groups is topical. Aim: to investigate an integral coefficient the activity of nonspecific reactions of lipid peroxidation in adolescent girls of the Buryat, Evenki and Tofalar ethnic groups, as compared to the indigenous ethnic groups, by applying. Methods: The 190 adolescent girls (Buryats, Evenki and Tofalar, and non-indigenous population (for example of Russians)) living in the Irkutsk region were the objects of research. The survey was carried out in expeditionary conditions, in the territories of compact residence of ethnic groups. To calculate the integral coefficient (oxidative stress coefficient - OSC) spectrophotometry and fluorometry methods we used. The individual indicators: primary, secondary and final products of lipid peroxidation and antioxidant defense components were measured. Results: According to the obtained data, a lower content of diene conjugates (DC) (2.41 times lower; p0.0001), ketodienes and conjugated trienes (KD and СT) (2.10 times lower; p=0.0003), -tocopherol (1.38 times lower p0.0001) with elevated levels of TBA-active products (1.53 times higher (p=0.0074) and superoxide dismutase activity (p=0.0008) in the Buryat ethnic girls group relative to similar parameters of girls in the non-ingenious population was observed. Girls of the Evenki ethnic group had higher values of -tocopherol (1.29 times higher; p=0.0136) and reduced form of glutathione (1.28 times higher; p=0.0012) compared to those of the non-indigenous population. Girls of Tofalar ethnic group had higher values of DC (1,5 times higher; p=0,0009), -tocopherol (1,28 times higher; p=0,0227) and retinol (1,34 times higher; p=0,0420), with reduced values of KD and CT (1,43 times lower; p=0,0044) compared to those of the corresponding non-indigenous population. Integral analysis of the non-specific reactions of lipid peroxidation state by integral coefficient showed its maximum values in the representatives of the Evenki ethnos and reduced values in the girls of Tofalar ethnos. Conclusion: The integral evaluation of the activity of nonspecific lipid peroxidation reactions in adolescent girls belonging to different Siberian ethnic groups has revealed certain differences, which are evolutionarily deterministic and may serve as a basis for further monitoring of health conditions and developing regional ethnospecific measures
{"title":"INTEGRAL ASSESSMENT OF NON-SPECIFIC LIPID PEROXIDATION REACTIONS IN ADOLESCENT GIRLS OF THE SIBERIAN ETHNOUS","authors":"M. Darenskaya, L. V. Rychkova, S. Kolesnikov, N. Semenova, L. Kolesnikova","doi":"10.17816/humeco105586","DOIUrl":"https://doi.org/10.17816/humeco105586","url":null,"abstract":"Introduction: Integral parameters, in particular, the oxidative stress coefficient, created by Scientific Centre for Family Health and Human Reproduction Problems, are more informative in contrast to individual indicators and can be used both for evaluation of pathological conditions and compensatory-adaptive reactions of the organism. The general decrease of the adaptation possibilities in the female population, especially indigenous peoples as a part of the reproductive potential of the nation has been noted. The estimation of the integral coefficient in adolescent girls living in different territories and belonging to different ethnic groups is topical. \u0000Aim: to investigate an integral coefficient the activity of nonspecific reactions of lipid peroxidation in adolescent girls of the Buryat, Evenki and Tofalar ethnic groups, as compared to the indigenous ethnic groups, by applying. \u0000Methods: The 190 adolescent girls (Buryats, Evenki and Tofalar, and non-indigenous population (for example of Russians)) living in the Irkutsk region were the objects of research. The survey was carried out in expeditionary conditions, in the territories of compact residence of ethnic groups. To calculate the integral coefficient (oxidative stress coefficient - OSC) spectrophotometry and fluorometry methods we used. The individual indicators: primary, secondary and final products of lipid peroxidation and antioxidant defense components were measured. \u0000Results: According to the obtained data, a lower content of diene conjugates (DC) (2.41 times lower; p0.0001), ketodienes and conjugated trienes (KD and СT) (2.10 times lower; p=0.0003), -tocopherol (1.38 times lower p0.0001) with elevated levels of TBA-active products (1.53 times higher (p=0.0074) and superoxide dismutase activity (p=0.0008) in the Buryat ethnic girls group relative to similar parameters of girls in the non-ingenious population was observed. Girls of the Evenki ethnic group had higher values of -tocopherol (1.29 times higher; p=0.0136) and reduced form of glutathione (1.28 times higher; p=0.0012) compared to those of the non-indigenous population. Girls of Tofalar ethnic group had higher values of DC (1,5 times higher; p=0,0009), -tocopherol (1,28 times higher; p=0,0227) and retinol (1,34 times higher; p=0,0420), with reduced values of KD and CT (1,43 times lower; p=0,0044) compared to those of the corresponding non-indigenous population. Integral analysis of the non-specific reactions of lipid peroxidation state by integral coefficient showed its maximum values in the representatives of the Evenki ethnos and reduced values in the girls of Tofalar ethnos. \u0000Conclusion: The integral evaluation of the activity of nonspecific lipid peroxidation reactions in adolescent girls belonging to different Siberian ethnic groups has revealed certain differences, which are evolutionarily deterministic and may serve as a basis for further monitoring of health conditions and developing regional ethnospecific measures ","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84710298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Unguryanu, Daria Stepovaia, I. Beliaevskaia, Svetlana Zakharova, Konstantin Bobykin, N. Volkov, D. Kuznetsova, E. Kosareva, Anna Glukhanova
Aim: to analyze the levels of contamination with heavy metals and radionuclides of forest mushrooms and berries growing in the Arkhangelsk region. Methods: data on the content of heavy metals (cadmium, mercury, lead, arsenic) and radionuclides (cesium-137 and strontium-90) in berries and mushrooms were studied based on the protocols of the Agrochemical Service Station Arkhangelskaya and the Center for Hygiene and Epidemiology in the Arkhangelsk Region and the Nenets Autonomous Okrug for 2015-2021. 201 samples of mushrooms and 175 samples of berries were analyzed. Results: The concentrations of heavy metals did not exceed the maximum permissible concentrations in 94% of the studied samples of mushrooms and 86% of the studied samples of berries. All samples of mushrooms and berries corresponded the hygienic standards for the content of radionuclides. The mean concentrations of mercury (0.013 mg/kg) and cadmium (0.040 mg/kg) in mushrooms were higher than the average concentrations of these metals in berries by 2.1 times (p = 0.002) and 1.8 times (p0.001), respectively. At the level of median concentration and 90th percentile, the content of mercury in tubular mushrooms (0.036 and 0.047 mg/kg, respectively) was 3.2 times higher compared to plate mushrooms (p = 0.003). The highest content of arsenic (0.067 mg/kg and 0.24 mg/kg, respectively) and lead (0.088 mg/kg and 0.15 mg/kg) were found in the berries of the large-sized shrubs at the level of average concentration and the 90th percentile compared to other shrub species, but the differences were not statistically significant. Conclusion: Mushrooms and berries from the Arkhangelsk region contain low concentrations of heavy metals and radionuclides. Mushrooms accumulate heavy metals and radionuclides more than berries. It is necessary to organize monitoring of the content of heavy metals in wild mushrooms and berries.
{"title":"ASSESSMENT OF THE CHEMICAL AND RADIOLOGICAL SAFETY OF WILD MUSHROOMS AND BERRIES GROWING IN THE ARKHANGELSK REGION","authors":"T. Unguryanu, Daria Stepovaia, I. Beliaevskaia, Svetlana Zakharova, Konstantin Bobykin, N. Volkov, D. Kuznetsova, E. Kosareva, Anna Glukhanova","doi":"10.17816/humeco110972","DOIUrl":"https://doi.org/10.17816/humeco110972","url":null,"abstract":"Aim: to analyze the levels of contamination with heavy metals and radionuclides of forest mushrooms and berries growing in the Arkhangelsk region. \u0000Methods: data on the content of heavy metals (cadmium, mercury, lead, arsenic) and radionuclides (cesium-137 and strontium-90) in berries and mushrooms were studied based on the protocols of the Agrochemical Service Station Arkhangelskaya and the Center for Hygiene and Epidemiology in the Arkhangelsk Region and the Nenets Autonomous Okrug for 2015-2021. 201 samples of mushrooms and 175 samples of berries were analyzed. \u0000Results: The concentrations of heavy metals did not exceed the maximum permissible concentrations in 94% of the studied samples of mushrooms and 86% of the studied samples of berries. All samples of mushrooms and berries corresponded the hygienic standards for the content of radionuclides. The mean concentrations of mercury (0.013 mg/kg) and cadmium (0.040 mg/kg) in mushrooms were higher than the average concentrations of these metals in berries by 2.1 times (p = 0.002) and 1.8 times (p0.001), respectively. At the level of median concentration and 90th percentile, the content of mercury in tubular mushrooms (0.036 and 0.047 mg/kg, respectively) was 3.2 times higher compared to plate mushrooms (p = 0.003). The highest content of arsenic (0.067 mg/kg and 0.24 mg/kg, respectively) and lead (0.088 mg/kg and 0.15 mg/kg) were found in the berries of the large-sized shrubs at the level of average concentration and the 90th percentile compared to other shrub species, but the differences were not statistically significant. \u0000Conclusion: Mushrooms and berries from the Arkhangelsk region contain low concentrations of heavy metals and radionuclides. Mushrooms accumulate heavy metals and radionuclides more than berries. It is necessary to organize monitoring of the content of heavy metals in wild mushrooms and berries.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83167193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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