I. Averyanova, E. Lugovaya, S. Vdovenko, Yu.V. Barbaruk
Background: Living in Russias Far North brings pronounced natural and social characteristics that exert an unfavourable influence on the human functional state. Objective: This study analyzed assessment of medical, physiological, and social factors determining the body functional state in northerners of different age groups. Methods: The research involved male residents of Magadan region, Caucasians by origin: one hundred and fifty-six young men aged 17-21 (mean age 18.5 0.6 yr), fifty-six men of the working age of 34-45 (mean age 37.4 0.5 yr) and forty-five elderly men at the age of 60-77 (mean age 65.9 1.1 yr). The participants somatometric variables were measured. The functioning of cardiovascular and respiratory systems, insulin resistance, as well as the pictures of blood biochemistry, vitamin D, trace element and basal metabolism were assessed. The subjective tobacco smoking and motor activity rates were also analyzed. Results: We can conclude that the body systemic functioning is increasingly stressed out with age. We determined that subjects, as they age, exhibit increased incidence of those with arterial hypertension, insulin resistance, and elevated blood glucose and atherogenicity coefficient levels. We also identified elevated bronchial obstruction index and lowered variables of respiratory functioning in older people who reported consistently high levels of tobacco consumption. Conclusion: The developed matrices illustrate the worsening observed in subjective functional reserves and increasing intensity occurred in body systems of examinees as they grow from ontogenesis of the youth to the elderly.
{"title":"Far North residents’ age-related peculiarities based on construction of functional state matrices","authors":"I. Averyanova, E. Lugovaya, S. Vdovenko, Yu.V. Barbaruk","doi":"10.17816/humeco111891","DOIUrl":"https://doi.org/10.17816/humeco111891","url":null,"abstract":"Background: Living in Russias Far North brings pronounced natural and social characteristics that exert an unfavourable influence on the human functional state. Objective: This study analyzed assessment of medical, physiological, and social factors determining the body functional state in northerners of different age groups. \u0000Methods: The research involved male residents of Magadan region, Caucasians by origin: one hundred and fifty-six young men aged 17-21 (mean age 18.5 0.6 yr), fifty-six men of the working age of 34-45 (mean age 37.4 0.5 yr) and forty-five elderly men at the age of 60-77 (mean age 65.9 1.1 yr). The participants somatometric variables were measured. The functioning of cardiovascular and respiratory systems, insulin resistance, as well as the pictures of blood biochemistry, vitamin D, trace element and basal metabolism were assessed. The subjective tobacco smoking and motor activity rates were also analyzed. \u0000Results: We can conclude that the body systemic functioning is increasingly stressed out with age. We determined that subjects, as they age, exhibit increased incidence of those with arterial hypertension, insulin resistance, and elevated blood glucose and atherogenicity coefficient levels. We also identified elevated bronchial obstruction index and lowered variables of respiratory functioning in older people who reported consistently high levels of tobacco consumption. \u0000Conclusion: The developed matrices illustrate the worsening observed in subjective functional reserves and increasing intensity occurred in body systems of examinees as they grow from ontogenesis of the youth to the elderly.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87007884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Fatkhutdinova, Guzel A. Timerbulatova, S. Zaripov, Lyalya I. Yapparova, A. Ablyaeva, Anatolii A. Saveliev, E. P. Sizova, R. Zalyalov
The aim of the study was to study the role of fine suspended particles in the atmospheric air in the formation of allergic, non-allergic and mixed phenotypes of bronchial asthma in adults. Methods. The analysis of atmospheric air pollution by fine particles in Kazan was carried out according to the database of social and hygienic monitoring of the FBUZ "Center for Hygiene and Epidemiology in the Republic of Tatarstan" for 2014-2020. To study the relationship between the level of atmospheric air pollution with fine particles and bronchial asthma in adults (18-65 years old), a retrospective analysis of the incidence of bronchial asthma (ICD-10 codes J45.0, J45.1, J45.8) was carried out during the same period among the population of Kazan. The regional medical information system "Electronic Health of the Republic of Tatarstan" was used. Statistical modeling was carried out using the method of mixed models based on the Poisson distribution or the negative binomial distribution. Results. The average annual absolute risk of bronchial asthma in the adult population of Kazan was 0.51 per 100 people aged 18-65 years, an increase of 0.09 per 100 people (17.6%) per year (p = 0.039). An increase in the annual maximum concentrations of PM2.5 by 10 g increased the absolute risk of non-allergic bronchial asthma by 0.066 per 100 people aged 18-65 years (p=0.043). Similar dependences, but without statistical significance at the level of p0.05, were found for such exposure parameters as the mass concentration of PM10 and the mass of particles deposited in the tracheobronchial and respiratory sections of the lungs. For allergic and mixed asthma, no statistically significant relationships with mass concentrations and deposited doses of suspended particles were found. Conclusions. Air pollution with fine suspended particles increases the risk of developing a non-allergic phenotype of adult bronchial asthma, which may be associated with specific pathogenetic mechanisms, including the reaction of the epithelium to the deposition of fine particles.
{"title":"Particulate matter in the ambient air as a risk factor of bronchial asthma in adults","authors":"L. Fatkhutdinova, Guzel A. Timerbulatova, S. Zaripov, Lyalya I. Yapparova, A. Ablyaeva, Anatolii A. Saveliev, E. P. Sizova, R. Zalyalov","doi":"10.17816/humeco109943","DOIUrl":"https://doi.org/10.17816/humeco109943","url":null,"abstract":"The aim of the study was to study the role of fine suspended particles in the atmospheric air in the formation of allergic, non-allergic and mixed phenotypes of bronchial asthma in adults. \u0000Methods. The analysis of atmospheric air pollution by fine particles in Kazan was carried out according to the database of social and hygienic monitoring of the FBUZ \"Center for Hygiene and Epidemiology in the Republic of Tatarstan\" for 2014-2020. To study the relationship between the level of atmospheric air pollution with fine particles and bronchial asthma in adults (18-65 years old), a retrospective analysis of the incidence of bronchial asthma (ICD-10 codes J45.0, J45.1, J45.8) was carried out during the same period among the population of Kazan. The regional medical information system \"Electronic Health of the Republic of Tatarstan\" was used. Statistical modeling was carried out using the method of mixed models based on the Poisson distribution or the negative binomial distribution. \u0000Results. The average annual absolute risk of bronchial asthma in the adult population of Kazan was 0.51 per 100 people aged 18-65 years, an increase of 0.09 per 100 people (17.6%) per year (p = 0.039). An increase in the annual maximum concentrations of PM2.5 by 10 g increased the absolute risk of non-allergic bronchial asthma by 0.066 per 100 people aged 18-65 years (p=0.043). Similar dependences, but without statistical significance at the level of p0.05, were found for such exposure parameters as the mass concentration of PM10 and the mass of particles deposited in the tracheobronchial and respiratory sections of the lungs. For allergic and mixed asthma, no statistically significant relationships with mass concentrations and deposited doses of suspended particles were found. \u0000Conclusions. Air pollution with fine suspended particles increases the risk of developing a non-allergic phenotype of adult bronchial asthma, which may be associated with specific pathogenetic mechanisms, including the reaction of the epithelium to the deposition of fine particles.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89627096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Reproductive health disorders in adolescent girls in the Kola North, the lack of studies of the physiological status of reproductive age girls living in the territory with high pollution by dust particles of apatite-nepheline ore, determine the relevance of this study, involving the identification of indicators of premorbid state. Objective. To estimate the physiological status of reproductive age girls living under chronic stress condition caused by exposure to anthropogenic and Arctic environment, to reveal possible prenosological deviations as indicators of premorbid state. Methods. The study design was an observational, analytic, cross-sectional, cohort study in 3 observational series: 2019, 2020, 2021, involving 54 female medical college students 16-20 years living in Apatity. Territorial morbidity of adolescents was analyzed on the basis of data from the MIAC of the Murmansk Regional Clinical Hospital named after P.A. Bayandin. Physiological status was assessed on the basis of the content of hypothalamic-pituitary-adrenocortical system (HPACS) hormones, metabolites of lipid peroxidation, antioxidant protection (AOP), vitamin D, lipids, carbohydrates using percentile distribution of indicator values. Significance of the differences was determined by Mann-Whitney U test, Kolmogorov-Smirnov test, t-criterion for independent samples. Results. It was shown that morbidity in adolescents with circulatory system diseases, skin and subcutaneous tissue diseases (atopic dermatitis), urogenital system diseases in Apatity exceeds corresponding values in other industrial polluted territories of the Murmansk region. Early effects of chronic exposure of the body to dust particles were revealed in more than 25% of the girls, which manifested themselves in increased secretion of adrenocorticotropic hormone, cortisol, thyrotropic hormone, in decreased somatotropic hormone, thyroxine, in reduced content of AOS enzymes. Hypovitaminosis of vitamin D was detected in 95% of girls, low values of low density lipoproteins was found in 50% of girls. Conclusion. Pre-nosological deviations of the physiological status in the conditions of technogenic pollution testify to the oppression of the body's protective systems and are predictors of morbidity and are subject to individual correction.
{"title":"PHYSIOLOGICAL STATUS OF REPRODUCTIVE AGE GIRLS UNDER CONDITIONS OF TECHNOGENIC IMPACT IN THE KOLA NORTH","authors":"N. Belisheva, A. A. Martynova, A. V. Korovkina","doi":"10.17816/humeco109941","DOIUrl":"https://doi.org/10.17816/humeco109941","url":null,"abstract":"Introduction. Reproductive health disorders in adolescent girls in the Kola North, the lack of studies of the physiological status of reproductive age girls living in the territory with high pollution by dust particles of apatite-nepheline ore, determine the relevance of this study, involving the identification of indicators of premorbid state. \u0000Objective. To estimate the physiological status of reproductive age girls living under chronic stress condition caused by exposure to anthropogenic and Arctic environment, to reveal possible prenosological deviations as indicators of premorbid state. \u0000Methods. The study design was an observational, analytic, cross-sectional, cohort study in 3 observational series: 2019, 2020, 2021, involving 54 female medical college students 16-20 years living in Apatity. Territorial morbidity of adolescents was analyzed on the basis of data from the MIAC of the Murmansk Regional Clinical Hospital named after P.A. Bayandin. Physiological status was assessed on the basis of the content of hypothalamic-pituitary-adrenocortical system (HPACS) hormones, metabolites of lipid peroxidation, antioxidant protection (AOP), vitamin D, lipids, carbohydrates using percentile distribution of indicator values. Significance of the differences was determined by Mann-Whitney U test, Kolmogorov-Smirnov test, t-criterion for independent samples. \u0000Results. It was shown that morbidity in adolescents with circulatory system diseases, skin and subcutaneous tissue diseases (atopic dermatitis), urogenital system diseases in Apatity exceeds corresponding values in other industrial polluted territories of the Murmansk region. Early effects of chronic exposure of the body to dust particles were revealed in more than 25% of the girls, which manifested themselves in increased secretion of adrenocorticotropic hormone, cortisol, thyrotropic hormone, in decreased somatotropic hormone, thyroxine, in reduced content of AOS enzymes. Hypovitaminosis of vitamin D was detected in 95% of girls, low values of low density lipoproteins was found in 50% of girls. \u0000Conclusion. Pre-nosological deviations of the physiological status in the conditions of technogenic pollution testify to the oppression of the body's protective systems and are predictors of morbidity and are subject to individual correction.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88166976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIM: To assess the effectiveness of technological measures to manage the risk to public health of exposure to atmospheric emissions from multi-fuel combined heat and power plants (CHP). METHODS: The study involved modeling the dispersion of emissions from the thermal power plants, calculation of surface concentrations, assessment of carcinogenic and non-carcinogenic risks to public health, and estimating the relative risk of mortality, referrals and hospitalizations based on WHO guidelines on atmospheric air quality. Predictive scenarios were constructed for thermal power plants, including the initial state, modernization with the help of technological and sanitary measures, and changes in the structure of the fuel balance. RESULTS: The use of low-temperature vortex fuel combustion technology in combination with a modernized dust and gas cleaning system significantly (p 0.001) decreased the predicted carcinogenic risk index by an average of 80.67%, non-carcinogenic risk index by 78.84%, and relative mortality risks and referrals to medical organizations by more than 80%. The use of a gas turbine plant increased the production of electric energy by 72.23%, thermal energy by 4.89%, and significantly (p 0.001) reduced the level of carcinogenic risk by 4460%, non-carcinogenic risk by 3547%, and relative risks of mortality, visits to medical organizations and hospitalizations by 3364%. CONCLUSION: The use of the best available technologies to modernize multi-fuel CHP plants significantly reduces the level of risk to public health while it increases the production of electric and thermal energy and maintaining the advantage of using both solid and gaseous fuels.
{"title":"Evaluation of the effectiveness of technological measures to manage the risk to public health when exposed to atmospheric emissions of multi-fuel combined heat and power plants","authors":"S. Petrov, Yurii Zhernov","doi":"10.17816/humeco110989","DOIUrl":"https://doi.org/10.17816/humeco110989","url":null,"abstract":"AIM: To assess the effectiveness of technological measures to manage the risk to public health of exposure to atmospheric emissions from multi-fuel combined heat and power plants (CHP). \u0000METHODS: The study involved modeling the dispersion of emissions from the thermal power plants, calculation of surface concentrations, assessment of carcinogenic and non-carcinogenic risks to public health, and estimating the relative risk of mortality, referrals and hospitalizations based on WHO guidelines on atmospheric air quality. Predictive scenarios were constructed for thermal power plants, including the initial state, modernization with the help of technological and sanitary measures, and changes in the structure of the fuel balance. \u0000RESULTS: The use of low-temperature vortex fuel combustion technology in combination with a modernized dust and gas cleaning system significantly (p 0.001) decreased the predicted carcinogenic risk index by an average of 80.67%, non-carcinogenic risk index by 78.84%, and relative mortality risks and referrals to medical organizations by more than 80%. The use of a gas turbine plant increased the production of electric energy by 72.23%, thermal energy by 4.89%, and significantly (p 0.001) reduced the level of carcinogenic risk by 4460%, non-carcinogenic risk by 3547%, and relative risks of mortality, visits to medical organizations and hospitalizations by 3364%. \u0000CONCLUSION: The use of the best available technologies to modernize multi-fuel CHP plants significantly reduces the level of risk to public health while it increases the production of electric and thermal energy and maintaining the advantage of using both solid and gaseous fuels.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79090051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: The reproductive health of a population depends on many factors one of which is chemical pollution of the environment caused by both natural conditions and man-made impacts. The population living in geochemical provinces is often subject to pathological conditions caused by a lack, excess or imbalance of macro- and microelements. This study was carried out in the Republic of Bashkortostan in areas of natural and man-made anomalies with excessive content of heavy metals in the environment. AIM: To analyze the demographic profile and assess the reproductive health of the population of the Trans-Ural zone of the Republic of Bashkortostan. MATERIALS AND METHODS: A descriptive ecological study of the trend of reproductive health of the population of the Trans-Ural zone of the Republic of Bashkortostan was carried out using average population indicators. Statistical data presented in the open press by the Ministry of Health of the Republic of Bashkortostan for the 20002020 period were used. These data included demographic indicators, infant mortality, frequency of congenital malformations, and morbidity of children within the first year of life. RESULTS: In all the areas studied, there was a tendency for a decrease in the birth rate and an increase in the mortality rate. The highest average birth rate of 19.8 was recorded in the Burzyansky District and the lowest of 13.1 in the Zilairsky District, which was higher than the republican average of 12.4. During the study period, there was a significant decrease in infant mortality both in the republic and in the Trans-Urals regions. Average infant mortality rates relative to congenital malformations among newborns in the Sibay, Baymaksky, and Zianchurinsky Districts as well as the relative risk of blood diseases in children of the first year of life in most of the studied areas was higher than the average republican level. CONCLUSION: Reproductive health of the population of Sibay for the period 20002020 is exposed to a higher risk of congenital malformations and infant mortality than the average republican level. In the Baymaksky, Zianchurinsky, Uchalinsky and Khaibullinsky Districts, the risk of developing blood diseases in children within the first year of life was higher than the average republican level. The results further indicate the need to take measures to reduce risks and improve the safety of reproductive health of the population of the mining region.
{"title":"Assessment of indicators of reproductive health of the population of the Trans-Ural Republic of Bashkortostan in 2000–2020","authors":"I. Semenova, Y. Rafikova","doi":"10.17816/humeco105718","DOIUrl":"https://doi.org/10.17816/humeco105718","url":null,"abstract":"BACKGROUND: The reproductive health of a population depends on many factors one of which is chemical pollution of the environment caused by both natural conditions and man-made impacts. The population living in geochemical provinces is often subject to pathological conditions caused by a lack, excess or imbalance of macro- and microelements. This study was carried out in the Republic of Bashkortostan in areas of natural and man-made anomalies with excessive content of heavy metals in the environment. \u0000AIM: To analyze the demographic profile and assess the reproductive health of the population of the Trans-Ural zone of the Republic of Bashkortostan. \u0000MATERIALS AND METHODS: A descriptive ecological study of the trend of reproductive health of the population of the Trans-Ural zone of the Republic of Bashkortostan was carried out using average population indicators. Statistical data presented in the open press by the Ministry of Health of the Republic of Bashkortostan for the 20002020 period were used. These data included demographic indicators, infant mortality, frequency of congenital malformations, and morbidity of children within the first year of life. \u0000RESULTS: In all the areas studied, there was a tendency for a decrease in the birth rate and an increase in the mortality rate. The highest average birth rate of 19.8 was recorded in the Burzyansky District and the lowest of 13.1 in the Zilairsky District, which was higher than the republican average of 12.4. During the study period, there was a significant decrease in infant mortality both in the republic and in the Trans-Urals regions. Average infant mortality rates relative to congenital malformations among newborns in the Sibay, Baymaksky, and Zianchurinsky Districts as well as the relative risk of blood diseases in children of the first year of life in most of the studied areas was higher than the average republican level. \u0000CONCLUSION: Reproductive health of the population of Sibay for the period 20002020 is exposed to a higher risk of congenital malformations and infant mortality than the average republican level. In the Baymaksky, Zianchurinsky, Uchalinsky and Khaibullinsky Districts, the risk of developing blood diseases in children within the first year of life was higher than the average republican level. The results further indicate the need to take measures to reduce risks and improve the safety of reproductive health of the population of the mining region.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83690490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. Sharipova, Mariia V. Ivkina, A. N. Arkhangelskaya, K. Gurevich
Due to the continual increase in the incidence of endocrine diseases in the world, their prevention and treatment have become topical. Diseases of the endocrine system are often accompanied by the development of comorbidities and complications, which negatively affect the quality of life and survival of patients. Currently, research is focused on the status of trace elements in patients with various diseases. Numerous current studies are devoted to investigating the influence of the balance of trace elements on the etiology and pathogenesis of diabetes mellitus, obesity, and some thyroid diseases, including autoimmune ones. The role of iodine, selenium, iron, zinc, and copper in the development and progression of these diseases has been established, but the findings of these studies are sometimes contradictory. This review focuses on national and foreign studies on the role of trace elements in the development of endocrine pathology, and gives a brief description of the most significant mineral substances, as well as the effect of their imbalance on the structure and function of the organs of the endocrine system. This review recommends further studies on this issue incorporating concomitant diseases, as well as the mutual influences of mineral substances on each other, which can lead to a change in the concentration of trace elements in the body.
{"title":"Role of microelements in the development of endocrine pathology","authors":"M. M. Sharipova, Mariia V. Ivkina, A. N. Arkhangelskaya, K. Gurevich","doi":"10.17816/humeco72102","DOIUrl":"https://doi.org/10.17816/humeco72102","url":null,"abstract":"Due to the continual increase in the incidence of endocrine diseases in the world, their prevention and treatment have become topical. Diseases of the endocrine system are often accompanied by the development of comorbidities and complications, which negatively affect the quality of life and survival of patients. Currently, research is focused on the status of trace elements in patients with various diseases. Numerous current studies are devoted to investigating the influence of the balance of trace elements on the etiology and pathogenesis of diabetes mellitus, obesity, and some thyroid diseases, including autoimmune ones. The role of iodine, selenium, iron, zinc, and copper in the development and progression of these diseases has been established, but the findings of these studies are sometimes contradictory. \u0000This review focuses on national and foreign studies on the role of trace elements in the development of endocrine pathology, and gives a brief description of the most significant mineral substances, as well as the effect of their imbalance on the structure and function of the organs of the endocrine system. This review recommends further studies on this issue incorporating concomitant diseases, as well as the mutual influences of mineral substances on each other, which can lead to a change in the concentration of trace elements in the body.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82516217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. METHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group. RESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively). CONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.
目的:探讨青春期脂肪性肝病超声征象与青春期激素代谢紊乱的性质及其与动脉粥样硬化危险因素的关系。方法:从阿尔汉格尔斯克选取120名年龄1217岁、有脂肪肝症状的青少年作为样本，检测其过氧化、慢性炎症和胰岛素抵抗指标。在检查时没有急性和慢性疾病的219名阿尔汉格尔斯克青少年被用作对照组。结果:青少年脂肪肝组总c反应蛋白(2.76 mg/ml)、脂质过氧化(531.28 mmol/l)、腰围(72.15 cm)、体重指数(25.70 kg/m2)、尿酸(0.29 mmol/l)、HOMA指数(2.24 IU)、胰岛素(11.92 IU/ml)、甘油三酯(0.91 mmol/l)、低密度脂蛋白胆固醇(2.20 mmol/l)的平均值均高于对照组(0.77 mg/ml, p 0.001);371.19 mmol/l, p=0.027;58.19 cm, p 0.001;25.70 kg/m2, p < 0.001;0.25 mmol/l, p 0.001;1.01 IU, p 0.001;5.90 uIU/ml, p 0.001;0.69 mmol/l, p 0.001;2.06 mmol/l, p=0.025)。结论:这些结果证实，非酒精性脂肪性肝病的发病因素(胰岛素抵抗，伴随腹部脂肪沉积的高胰岛素血症，脂质过氧化活化，动脉粥样硬化性血脂异常，高尿酸血症和慢性炎症)应在青少年预防，诊断，监测和治疗非酒精性脂肪性肝病时考虑。
{"title":"Hormonal and metabolic features of puberty in adolescents with ultrasound signs of fatty hepatosis (on the example of Arkhangelsk)","authors":"S. Malyavskaya, A. Lebedev, G. Kostrova","doi":"10.17816/humeco109055","DOIUrl":"https://doi.org/10.17816/humeco109055","url":null,"abstract":"AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. \u0000METHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group. \u0000RESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively). \u0000CONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72379590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: In the context of the development of measures aimed at reducing the mortality of the population, it is BACKGROUND: In developing measures to reduce mortality in the population, it is important not to directly analyze the mortality of the population but to study its manageable components attributed to preventable and treatable deaths. AIM: To analyze trends in mortality due to preventable and treatable causes in the population of the Krasnoyarsk Territory. MATERIALS AND METHODS: A retrospective observational study was done using data from primary mortality databases of urban districts and municipal districts of the Krasnoyarsk Territory for the period 19992020, as well as data from the Office of the Federal State Statistics Service for the Krasnoyarsk Territory, the Republic of Khakassia and the Republic of Tyva on the population. The study examines how f preventable and curable causes contribute to the mortality structure of the population of the Krasnoyarsk Territory for the period 19992020. RESULTS: Over the period 19992019, the mortality rate of the population decreased by 13.4% (from 1413.2 to 1224.2 cases per 100,000 people), but in 2020 mortality rate increased by 16.7%, becoming slightly higher than its 1999 level. Analysis of the structure of mortality from leading causes of mortality showed a systematic increase in the proportion of unavoidable and incurable causes from 1999 to 2020. CONCLUSION: The results of this study can serve as a guideline for determining the reserves for reducing the mortality of the population and for determining promising directions for reducing it at the regional level. However, to achieve this, a more detailed analysis of the mortality structure of the population is required in order to identify groups of headings, headings or individual causes of death, for which there is a high proportion of preventable and curable mortality.
{"title":"Dynamics of mortality of the population of the Krasnoyarsk Territory from preventable and treatable causes","authors":"A. Mironova, A. Narkevich","doi":"10.17816/humeco109911","DOIUrl":"https://doi.org/10.17816/humeco109911","url":null,"abstract":"INTRODUCTION: In the context of the development of measures aimed at reducing the mortality of the population, it is BACKGROUND: In developing measures to reduce mortality in the population, it is important not to directly analyze the mortality of the population but to study its manageable components attributed to preventable and treatable deaths. \u0000AIM: To analyze trends in mortality due to preventable and treatable causes in the population of the Krasnoyarsk Territory. \u0000MATERIALS AND METHODS: A retrospective observational study was done using data from primary mortality databases of urban districts and municipal districts of the Krasnoyarsk Territory for the period 19992020, as well as data from the Office of the Federal State Statistics Service for the Krasnoyarsk Territory, the Republic of Khakassia and the Republic of Tyva on the population. The study examines how f preventable and curable causes contribute to the mortality structure of the population of the Krasnoyarsk Territory for the period 19992020. \u0000RESULTS: Over the period 19992019, the mortality rate of the population decreased by 13.4% (from 1413.2 to 1224.2 cases per 100,000 people), but in 2020 mortality rate increased by 16.7%, becoming slightly higher than its 1999 level. Analysis of the structure of mortality from leading causes of mortality showed a systematic increase in the proportion of unavoidable and incurable causes from 1999 to 2020. \u0000CONCLUSION: The results of this study can serve as a guideline for determining the reserves for reducing the mortality of the population and for determining promising directions for reducing it at the regional level. However, to achieve this, a more detailed analysis of the mortality structure of the population is required in order to identify groups of headings, headings or individual causes of death, for which there is a high proportion of preventable and curable mortality.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74801019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Vorobyeva, Alyona I. Vorobyeva, A. S. Vorontsova
BACKGROUND: Fundamental scientific research and practical medicine indicate that certain genes are potentially involved in the pathogenesis of oxidative stress. AIM: to determine the prevalence of polymorphic genes that cause oxidative stress in the Nenets ethnic group of the Vaigach Island of the Nenets Autonomous Okrug and compare it with that of other ethnic groups. MATERIALS AND METHODS: A molecular genetic study of the genes involved in oxidative stress in 44 representatives of the Nenets ethnic group permanently residing on the Vaygach Island was carried out. Data were analyzed using the STATA 2016 program and Microsoft Excel 2010. The assessment of the deviation of genotypic distributions from the HardyWeinberg equilibrium was carried out using the Pearson 2 test. Calculations were performed using the online program HardyWeinberg equilibrium calculator (HWEC). RESULTS: The prevalence of the main polymorphic variants of the oxidative system genes in the studied ethnic group was similar to that in European populations, with the exception of the SOD2 (rs4880), CYP1A1 (rs1048943), CAT (rs1001179) with prevalences of 97,73%, 20,45%, 13,64%, respectively. The oxidative system genes: the SOD2 (rs4880 and rs1141718), and CAT (rs1001179) were specific to the indigenous ethnic group of Vaygach Island. CONCLUSION: The study of the nature of genetic diversity in specific geographical, ethnic groups will allow us to reconstruct the genetic history of populations, and identify traces of natural selection associated with adaptive variability.
{"title":"Genetic predictors of oxidative stress in the indigenous ethnous of the Arctic","authors":"N. Vorobyeva, Alyona I. Vorobyeva, A. S. Vorontsova","doi":"10.17816/humeco109591","DOIUrl":"https://doi.org/10.17816/humeco109591","url":null,"abstract":"BACKGROUND: Fundamental scientific research and practical medicine indicate that certain genes are potentially involved in the pathogenesis of oxidative stress. \u0000AIM: to determine the prevalence of polymorphic genes that cause oxidative stress in the Nenets ethnic group of the Vaigach Island of the Nenets Autonomous Okrug and compare it with that of other ethnic groups. \u0000MATERIALS AND METHODS: A molecular genetic study of the genes involved in oxidative stress in 44 representatives of the Nenets ethnic group permanently residing on the Vaygach Island was carried out. Data were analyzed using the STATA 2016 program and Microsoft Excel 2010. The assessment of the deviation of genotypic distributions from the HardyWeinberg equilibrium was carried out using the Pearson 2 test. Calculations were performed using the online program HardyWeinberg equilibrium calculator (HWEC). \u0000RESULTS: The prevalence of the main polymorphic variants of the oxidative system genes in the studied ethnic group was similar to that in European populations, with the exception of the SOD2 (rs4880), CYP1A1 (rs1048943), CAT (rs1001179) with prevalences of 97,73%, 20,45%, 13,64%, respectively. The oxidative system genes: the SOD2 (rs4880 and rs1141718), and CAT (rs1001179) were specific to the indigenous ethnic group of Vaygach Island. \u0000CONCLUSION: The study of the nature of genetic diversity in specific geographical, ethnic groups will allow us to reconstruct the genetic history of populations, and identify traces of natural selection associated with adaptive variability.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77873303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Panchenko, A. Agumava, L. Pavlova, A. Panchenko, M. Timina
Telomeres are complex nucleoprotein structures with specific proteins of noncoding terminal regions of linear chromosomes of eukaryotic cells. Telomere DNA consists of a large number of short sequence repeats (TTAGGG in vertebrates). Telomeres protect chromosomes from their fusion and degradation, limit the proliferative potential of the cell, participate in the segregation of chromosomes during cell division, etc. Reduction of telomeres length is an important factor with significant impact on cell viability and function, aging, and leads to the development of various diseases including cancer. Alcohol abuse has a significant impact on a person's health. Ethanol consumption by a human may affect the length of chromosome telomeres on the cellular level. Current review presents an analysis of clinical and epidemiological studies on the effect of alcohol consumption on telomere length. Methods for telomere length determination and their applicability for clinical use with impact on research results are discussed. An association of alcohol consumption with shortening of telomeres has been shown in some studies with certain populations, including individuals with alcohol abuse, alcohol dependence and some genetic variants of alcohol metabolism enzymes but not in the general population. The analysis of reviewed studies allows to conclude that they are ambiguous and that there is further need to study the effect of alcohol on telomere length using modern methods of it determination.
{"title":"THE REVIEW OF STUDIES ON ASSOCIATION OF ALCOHOL CONSUMPTION WITH TELOMERE LENGTH IN HUMANS","authors":"A. Panchenko, A. Agumava, L. Pavlova, A. Panchenko, M. Timina","doi":"10.17816/humeco109491","DOIUrl":"https://doi.org/10.17816/humeco109491","url":null,"abstract":"Telomeres are complex nucleoprotein structures with specific proteins of noncoding terminal regions of linear chromosomes of eukaryotic cells. Telomere DNA consists of a large number of short sequence repeats (TTAGGG in vertebrates). Telomeres protect chromosomes from their fusion and degradation, limit the proliferative potential of the cell, participate in the segregation of chromosomes during cell division, etc. Reduction of telomeres length is an important factor with significant impact on cell viability and function, aging, and leads to the development of various diseases including cancer. Alcohol abuse has a significant impact on a person's health. Ethanol consumption by a human may affect the length of chromosome telomeres on the cellular level. Current review presents an analysis of clinical and epidemiological studies on the effect of alcohol consumption on telomere length. Methods for telomere length determination and their applicability for clinical use with impact on research results are discussed. An association of alcohol consumption with shortening of telomeres has been shown in some studies with certain populations, including individuals with alcohol abuse, alcohol dependence and some genetic variants of alcohol metabolism enzymes but not in the general population. The analysis of reviewed studies allows to conclude that they are ambiguous and that there is further need to study the effect of alcohol on telomere length using modern methods of it determination.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89874568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：