{"title":"Éxitos y retos para el control de la toxoplasmosis congénita en Colombia","authors":"Jorge E. Gómez-Marín","doi":"10.22354/24223794.1145","DOIUrl":"https://doi.org/10.22354/24223794.1145","url":null,"abstract":"","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"1069 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heitmar Santiago Infante-Fernández, Nicolás González-Gacharná, Santiago Diaz Pinillos, Nairo Cano Arenas
Pyogenic liver abscess is a high-incidence disease, in which hypervirulent (hypermucoviscous) Klebsiella pneumoniae (KP) has become more relevant due to its ability to spread and infect other tissues, among which endogenous endophthalmitis (EE) is the most common complication. A patient with right-sided abdominal pain, vomiting, anorexia, fever, and jaundice was diagnosed with a KP liver abscess that was drained and treated with ampicillin/sulbactam plus metronidazole. Subsequently, he had a recurrence of the liver abscess plus rapidly progressive ocular symptoms that raised suspicion of EE. Due to the severity of the infection, eye enucleation was required and despite the natural resistance pattern, the patient only improved after meropenem was prescribed. Any ocular symptoms in patients with KP liver abscess should raise suspicion of EE, contributing to an early diagnosis and treatment. It is possible that despite the antibiogram results, only broad-spectrum antibiotics may avoid vision loss and improve clinical outcomes.
化脓性肝脓肿是一种高发疾病，其中高病毒性（高黏液性）肺炎克雷伯氏菌（KP）因其传播和感染其他组织的能力而变得越来越重要，其中内源性眼内炎（EE）是最常见的并发症。一名患者出现右侧腹痛、呕吐、厌食、发热和黄疸，被诊断为 KP 肝脓肿，经引流后用氨苄西林/舒巴坦加甲硝唑治疗。随后，他的肝脓肿复发，眼部症状也迅速加重，这引起了对 EE 的怀疑。由于感染严重，需要进行眼球摘除术，尽管存在天然耐药模式，但在开具美罗培南处方后，患者的病情才有所好转。KP 肝脓肿患者的任何眼部症状都应引起对 EE 的怀疑，从而有助于早期诊断和治疗。尽管有抗生素图谱结果，但只有广谱抗生素才有可能避免视力丧失并改善临床预后。
{"title":"Endogenous endophthalmitis and liver abscess due to presumed-Hypervirulent Klebsiella pneumoniae: a case report.","authors":"Heitmar Santiago Infante-Fernández, Nicolás González-Gacharná, Santiago Diaz Pinillos, Nairo Cano Arenas","doi":"10.22354/24223794.1152","DOIUrl":"https://doi.org/10.22354/24223794.1152","url":null,"abstract":"Pyogenic liver abscess is a high-incidence disease, in which hypervirulent (hypermucoviscous) Klebsiella pneumoniae (KP) has become more relevant due to its ability to spread and infect other tissues, among which endogenous endophthalmitis (EE) is the most common complication. A patient with right-sided abdominal pain, vomiting, anorexia, fever, and jaundice was diagnosed with a KP liver abscess that was drained and treated with ampicillin/sulbactam plus metronidazole. Subsequently, he had a recurrence of the liver abscess plus rapidly progressive ocular symptoms that raised suspicion of EE. Due to the severity of the infection, eye enucleation was required and despite the natural resistance pattern, the patient only improved after meropenem was prescribed. Any ocular symptoms in patients with KP liver abscess should raise suspicion of EE, contributing to an early diagnosis and treatment. It is possible that despite the antibiogram results, only broad-spectrum antibiotics may avoid vision loss and improve clinical outcomes.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"89 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrés Bravo-González, Daniel Villa-Tamayo, Tomás Giraldo-Hinestroza, Nicolás Manjarrés-Sierra, Diego Córdoba-Alzate, Carolina Buitrago-Salazar, Hernán Carvajal-Restrepo, M. Romero-Montoya, Miryam Sánchez-Jiménez, N. Cardona-Castro
Objective: To identify the profile of intestinal parasitosis in children of four populations in the municipalities of Quibdó, Apartadó, Guachené, and Granada, Colombia, in 2012. Material and methods: A cross-sectional study was conducted using a secondary source of information, in which sociodemographic factors associated with the presence of parasites were analyzed in a univariate and bivariate manner. Results: A total of 240 individuals were analyzed. Two thirds of them were parasitized. The most frequent species were Entamoeba histolytica/dispar (22.9%), Endolimax nana (19.2%), Blastocystis hominins (19.2%), and Giardia intestinalis (20.8%). An association between inadequate excreta disposal (latrine or septic tank) and the presence of parasitic colonization was found with a prevalence ratio (PR) of 1.34 [1.14, 1.59] (p=0.005). Similarly, housing construction with wood or baharequewas 1.31 times more frequent in subjects with parasitic forms in their stool samples than those with brick houses.Discussion: A higher frequency of intestinal parasites was found for the different age groups compared to several reports worldwide and in Latin America. The most frequent species of parasites were similar to those reported in the literature.Conclusions: Isolated populations in Colombia, such as those studied, have a higher frequency of intestinal parasites than other populations.
{"title":"Prevalence and risk factors related to intestinal parasitosis in children under 18 years of age in four populations of Colombia: a cross-sectional study","authors":"Andrés Bravo-González, Daniel Villa-Tamayo, Tomás Giraldo-Hinestroza, Nicolás Manjarrés-Sierra, Diego Córdoba-Alzate, Carolina Buitrago-Salazar, Hernán Carvajal-Restrepo, M. Romero-Montoya, Miryam Sánchez-Jiménez, N. Cardona-Castro","doi":"10.22354/24223794.1149","DOIUrl":"https://doi.org/10.22354/24223794.1149","url":null,"abstract":"Objective: To identify the profile of intestinal parasitosis in children of four populations in the municipalities of Quibdó, Apartadó, Guachené, and Granada, Colombia, in 2012. \u0000Material and methods: A cross-sectional study was conducted using a secondary source of information, in which sociodemographic factors associated with the presence of parasites were analyzed in a univariate and bivariate manner. \u0000Results: A total of 240 individuals were analyzed. Two thirds of them were parasitized. The most frequent species were Entamoeba histolytica/dispar (22.9%), Endolimax nana (19.2%), Blastocystis hominins (19.2%), and Giardia intestinalis (20.8%). An association between inadequate excreta disposal (latrine or septic tank) and the presence of parasitic colonization was found with a prevalence ratio (PR) of 1.34 [1.14, 1.59] (p=0.005). Similarly, housing construction with wood or baharequewas 1.31 times more frequent in subjects with parasitic forms in their stool samples than those with brick houses.Discussion: A higher frequency of intestinal parasites was found for the different age groups compared to several reports worldwide and in Latin America. The most frequent species of parasites were similar to those reported in the literature.Conclusions: Isolated populations in Colombia, such as those studied, have a higher frequency of intestinal parasites than other populations.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"214 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge Alberto Cortés, Martha Carolina Valderrama-Ríos, Lilian Torregrosa-Almonacid, Cándida Díaz-Brochero, Laura Cristina Nócua-Báez, E. P. Vergara, Felipe Vargas-Barato, Bibiana Jeannette Escobar, Oscar A. Guevara, Julián Mauricio Parada, Oscar Alberto Velásquez, Mauricio Zuluaga Botero, Carlos Oliver Valderrama-Molina, C. F. Grillo-Ardila, German Esparza, Karina María Vélez, Rosibel Prieto-Silva
Las infecciones asociadas a la atención de la salud (IAAS) son el evento adverso más frecuentemente reportado en todo el mundo, siendo la infección del sitio quirúrgico (ISQ) la IAAS con mayor incidencia en los países de ingresos bajos y medios, como Colombia, con consecuencias importantes para los pacientes, la sociedad y el sistema de salud, debido al incremento en morbilidad, mortalidad y costos que genera. La presente guía contiene recomendaciones perioperatorias para la prevención de la ISQ, basadas en la evidencia, realizadas mediante el proceso de adaptación de guías de práctica clínica para el contexto colombiano.
{"title":"Guía de práctica clínica para la prevención de la infección del sitio quirúrgico","authors":"Jorge Alberto Cortés, Martha Carolina Valderrama-Ríos, Lilian Torregrosa-Almonacid, Cándida Díaz-Brochero, Laura Cristina Nócua-Báez, E. P. Vergara, Felipe Vargas-Barato, Bibiana Jeannette Escobar, Oscar A. Guevara, Julián Mauricio Parada, Oscar Alberto Velásquez, Mauricio Zuluaga Botero, Carlos Oliver Valderrama-Molina, C. F. Grillo-Ardila, German Esparza, Karina María Vélez, Rosibel Prieto-Silva","doi":"10.22354/24223794.1151","DOIUrl":"https://doi.org/10.22354/24223794.1151","url":null,"abstract":"Las infecciones asociadas a la atención de la salud (IAAS) son el evento adverso más frecuentemente reportado en todo el mundo, siendo la infección del sitio quirúrgico (ISQ) la IAAS con mayor incidencia en los países de ingresos bajos y medios, como Colombia, con consecuencias importantes para los pacientes, la sociedad y el sistema de salud, debido al incremento en morbilidad, mortalidad y costos que genera. La presente guía contiene recomendaciones perioperatorias para la prevención de la ISQ, basadas en la evidencia, realizadas mediante el proceso de adaptación de guías de práctica clínica para el contexto colombiano.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"452 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Patiño-Niño, Ana María Monsalve-Quintero, Laura Torres-Canchala, Camila Ariza-Insignares, Inés Elvira Gómez, Lina M. Sandoval-Calle, Jessica Pino, Paola Marsela Pérez-Camacho
Introducción: La meningitis y encefalitis son neuro infecciones potencialmente fatales para la población pediátrica. La incidencia de meningitis es de 4 a 30 casos por 100.000 habitantes y para encefalitis es de 3 a 7 casos por 100.000 habitantes.Materiales y método: Se realizó un estudio observacional, descriptivo, retrospectivo con el objetivo de identificar las características clínicas, microbiológicas y desenlaces de una cohorte de pacientes pediátricos con diagnóstico de encefalitis o meningitis, de una institución de alta complejidad en Cali, Colombia durante marzo del 2017 y diciembre del 2020. Resultados: Se analizaron las historias clínicas de pacientes atendidos en la Fundación Valle del Lili durante el periodo mencionado y se realizó un análisis estadístico descriptivo encontrando mayor proporción de aislamiento de Streptococcus agalactiae en los casos de etiología bacteriana, mientras que el Enterovirus fue el microorganismo más frecuentemente aislado en los casos de etiología viral. El síntoma más reportado al ingreso fue fiebre en el 78.6% de los pacientes, seguidode emesis (61.9%) y alteración del sensorio (52.4%).Conclusiones: Nuestro estudio demuestra la importancia de las pruebas moleculares para el apropiado diagnóstico etiológico y manejo de las meningitis y encefalitis.
{"title":"Caracterización clínica, microbiológica y desenlaces de una cohorte de pacientes pediátricos con diagnóstico de encefalitis/meningitis de una institución de alta complejidad en Cali-Colombia","authors":"J. Patiño-Niño, Ana María Monsalve-Quintero, Laura Torres-Canchala, Camila Ariza-Insignares, Inés Elvira Gómez, Lina M. Sandoval-Calle, Jessica Pino, Paola Marsela Pérez-Camacho","doi":"10.22354/24223794.1147","DOIUrl":"https://doi.org/10.22354/24223794.1147","url":null,"abstract":"Introducción: La meningitis y encefalitis son neuro infecciones potencialmente fatales para la población pediátrica. La incidencia de meningitis es de 4 a 30 casos por 100.000 habitantes y para encefalitis es de 3 a 7 casos por 100.000 habitantes.Materiales y método: Se realizó un estudio observacional, descriptivo, retrospectivo con el objetivo de identificar las características clínicas, microbiológicas y desenlaces de una cohorte de pacientes pediátricos con diagnóstico de encefalitis o meningitis, de una institución de alta complejidad en Cali, Colombia durante marzo del 2017 y diciembre del 2020. \u0000Resultados: Se analizaron las historias clínicas de pacientes atendidos en la Fundación Valle del Lili durante el periodo mencionado y se realizó un análisis estadístico descriptivo encontrando mayor proporción de aislamiento de Streptococcus agalactiae en los casos de etiología bacteriana, mientras que el Enterovirus fue el microorganismo más frecuentemente aislado en los casos de etiología viral. El síntoma más reportado al ingreso fue fiebre en el 78.6% de los pacientes, seguidode emesis (61.9%) y alteración del sensorio (52.4%).Conclusiones: Nuestro estudio demuestra la importancia de las pruebas moleculares para el apropiado diagnóstico etiológico y manejo de las meningitis y encefalitis.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"60 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dany Cristina Cruz-Agudelo, Manuela Bedoya-Vélez, Libia María Rodríguez-Padilla, M. N. Campo-Campo, J. E. Sanín-Blair, Juan Alejandro Londoño-Montoya, J. H. Gutiérrez-Marín, R. García-Posada
Objetivo: describir los resultados perinatales de gestantes con sospecha de seroconversión o confirmación de toxoplasmosis gestacional y la evolución clínica de sus neonatos hasta el mes de vida en una institución de alta complejidad, 2015-2021.Materiales y métodos: estudio descriptivo retrospectivo que incluyó gestantes quienes fueron referidas al servicio de medicina materno fetal por toxoplasmosis gestacional. Se tuvo en cuenta serologías positivas para esta patología, hallazgos ecográficos, reacción en cadena de polimerasa en líquido amniótico y serologías del neonato. La información de las variables clínicas y resultados de prueba serológicas se recolectó a través de historias clínicas.Resultados: Se incluyeron 209 pacientes, la mediana de edad gestacional al momento de la realización de las pruebas serológicas en institución de atención inicial, fue 16 semanas (RIC: 10-24 semanas). Los resultados serológicos fueron positivos para Inmunoglobulina G (IgG) en 191/ 208 (91,8%) y para inmunoglobulina M (IgM) 194/209 (92,8%).De las pacientes con IgG e IgM positivas, se le realizó prueba de avidez a 60 (28,7%), la cual fue baja en 15 (26,8%) pacientes. A 76 (36,4%) gestantes se les realizó la prueba de reacción en cadena de polimerasa en líquido amniótico, de estas, 15 (19,7%) tuvieron resultados positivos para diagnóstico de toxoplasmosis congénita, de las cuales en nueve casos los recién nacidos presentaron hallazgos positivos en el examen oftalmológico inicial y / o en la ecografía transfontanelar, confirmando los hallazgos ecográficos prenatales. La ecografía de detalle anatómico se realizó en 188 (90%) de las gestantes, donde se encontró alguna alteración en 47 (25,0%) de los casos.Conclusiones: La interpretación serológica y la ecografía obstétrica permitieron identificar una población de gestantes con la infección a quien se le ofreció el tratamiento disponible, sin embargo, existieron casos de toxoplasmosis congénita en ocasiones fueron fatales o con compromiso neurológico grave en la población estudiada.
{"title":"Toxoplasmosis gestacional: desenlaces obstétricos y resultados perinatales en un hospital de referencia en Medellín, Colombia. 2015-2021. Un estudio descriptivo","authors":"Dany Cristina Cruz-Agudelo, Manuela Bedoya-Vélez, Libia María Rodríguez-Padilla, M. N. Campo-Campo, J. E. Sanín-Blair, Juan Alejandro Londoño-Montoya, J. H. Gutiérrez-Marín, R. García-Posada","doi":"10.22354/24223794.1150","DOIUrl":"https://doi.org/10.22354/24223794.1150","url":null,"abstract":"Objetivo: describir los resultados perinatales de gestantes con sospecha de seroconversión o confirmación de toxoplasmosis gestacional y la evolución clínica de sus neonatos hasta el mes de vida en una institución de alta complejidad, 2015-2021.Materiales y métodos: estudio descriptivo retrospectivo que incluyó gestantes quienes fueron referidas al servicio de medicina materno fetal por toxoplasmosis gestacional. Se tuvo en cuenta serologías positivas para esta patología, hallazgos ecográficos, reacción en cadena de polimerasa en líquido amniótico y serologías del neonato. La información de las variables clínicas y resultados de prueba serológicas se recolectó a través de historias clínicas.Resultados: Se incluyeron 209 pacientes, la mediana de edad gestacional al momento de la realización de las pruebas serológicas en institución de atención inicial, fue 16 semanas (RIC: 10-24 semanas). Los resultados serológicos fueron positivos para Inmunoglobulina G (IgG) en 191/ 208 (91,8%) y para inmunoglobulina M (IgM) 194/209 (92,8%).De las pacientes con IgG e IgM positivas, se le realizó prueba de avidez a 60 (28,7%), la cual fue baja en 15 (26,8%) pacientes. A 76 (36,4%) gestantes se les realizó la prueba de reacción en cadena de polimerasa en líquido amniótico, de estas, 15 (19,7%) tuvieron resultados positivos para diagnóstico de toxoplasmosis congénita, de las cuales en nueve casos los recién nacidos presentaron hallazgos positivos en el examen oftalmológico inicial y / o en la ecografía transfontanelar, confirmando los hallazgos ecográficos prenatales. La ecografía de detalle anatómico se realizó en 188 (90%) de las gestantes, donde se encontró alguna alteración en 47 (25,0%) de los casos.Conclusiones: La interpretación serológica y la ecografía obstétrica permitieron identificar una población de gestantes con la infección a quien se le ofreció el tratamiento disponible, sin embargo, existieron casos de toxoplasmosis congénita en ocasiones fueron fatales o con compromiso neurológico grave en la población estudiada.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"1048 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge E. Gomez-Marin, Alfonso J. Rodriguez-Morales
{"title":"La ciencia abierta y sus costos: un gran reto para los sistemas de ciencia públicos","authors":"Jorge E. Gomez-Marin, Alfonso J. Rodriguez-Morales","doi":"10.22354/24223794.1138","DOIUrl":"https://doi.org/10.22354/24223794.1138","url":null,"abstract":"","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Contreras-Arrieta, Henry Murrain, Beatriz Helena Vallejo, Luz Adriana Camargo López, Fernanda Hernández, Nubia Velasco, Juan Sebastián Garzón, Silvia Restrepo, Andrea Ramírez Varela
Worldwide COVID-19 vaccination began in December 2020 as an event without precedents in public health history. Currently, around 12.000 million doses have been given, constituting a massive global effort to fight the pandemic. By June 2023, 70.3% of the world’s population has been vaccinated, which is almost the 80% of the goal set by the World Health Organization (WHO). Despite va¬ccine availability, literature describes misinformation amongst other complex and multifactorial challenges related to low vaccination coverages against COVID-19. Therefore, the success of vaccine initiatives globally highly depends on the strategies to strengthen pedagogy in public health and risk communication, so there is an adequate level of knowledge, acceptance and trust in the process and decision-making regarding COVID-19 vaccination. The objective of this revision is to present basic concepts, available tools, and recommendations for developing strategies on health pedagogy, risk communication, and community involvement to promote vaccination. In addition, these insights were based on lessons learned during the COVID-19 pandemic in Bogotá, where the effective implementation of a timely, clear, and targeted communication strategy based in behavioral science principles played a crucial role in the progress of vaccination efforts.
{"title":"Vaccination against COVID-19 in Bogotá - Colombia: lessons and strategies in health pedagogy, risk communication and community participation, using behavioral sciences","authors":"Sandra Contreras-Arrieta, Henry Murrain, Beatriz Helena Vallejo, Luz Adriana Camargo López, Fernanda Hernández, Nubia Velasco, Juan Sebastián Garzón, Silvia Restrepo, Andrea Ramírez Varela","doi":"10.22354/24223794.1142","DOIUrl":"https://doi.org/10.22354/24223794.1142","url":null,"abstract":"Worldwide COVID-19 vaccination began in December 2020 as an event without precedents in public health history. Currently, around 12.000 million doses have been given, constituting a massive global effort to fight the pandemic. By June 2023, 70.3% of the world’s population has been vaccinated, which is almost the 80% of the goal set by the World Health Organization (WHO). Despite va¬ccine availability, literature describes misinformation amongst other complex and multifactorial challenges related to low vaccination coverages against COVID-19. Therefore, the success of vaccine initiatives globally highly depends on the strategies to strengthen pedagogy in public health and risk communication, so there is an adequate level of knowledge, acceptance and trust in the process and decision-making regarding COVID-19 vaccination. The objective of this revision is to present basic concepts, available tools, and recommendations for developing strategies on health pedagogy, risk communication, and community involvement to promote vaccination. In addition, these insights were based on lessons learned during the COVID-19 pandemic in Bogotá, where the effective implementation of a timely, clear, and targeted communication strategy based in behavioral science principles played a crucial role in the progress of vaccination efforts.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Carlos Alzate-Angel, Melissa Gutierrez-Gomez, Hector Mueses-Marin, Sandra Valderrama-Beltran, Beatriz Hernandez, Otto Sussmann-Peña, Ernesto Martinez-Buitrago
Objective: People living with HIV (PLWH); can be especially vulnerable to the effects of SARS Co V 2 and COVID 19. In this study, we evaluate the factors associated with acquiring COVID 19 and the severity of the infection among PLWH.
Materials and methods: Through a case-control study nested in a cohort, where cases were PLWH diagnosed with COVID 19; and controls were PLWH without the infection, 476 people were evaluated between May 1, 2020, and February 28, 2021. A univariate analysis was performed with the variables considered candidates. Binary logistic regression models were conducted for the COVID 19 outcome, and among those diagnosed with the infection, regression models for the outcome of hospitalization vs. outpatient treatment.
Results: Among 238 PLWH diagnosed with COVID 19, receiving integrase inhibitors p < 0.001 (CI 95% 0.27,0.72) or protease inhibitors p 0.034 (CI 95%0.42,0.97) within their antiretroviral regime, was associated with a lower probability of developing COVID 19. 196 (82,35%) of the 238 cases received outpatient treatment, and 42 (17,64%) required hospitalization. In this case, being older than 50 years p < 0.001 (CI 95% 1.8,9.64) and having obesity as a comorbidity p 0.017 (CI 95% 1.34,17.93) increased the possibility of requiring hospitalization, while receiving antiretroviral treatment or having received vaccination against influenza, decreased the likelihood of this outcome.
Conclusions: There are still many questions regarding whether there is a differential risk of acquiring COVID 19 among PLWH. Antiretroviral treatment with integrase or protease inhibitors; was associated with a lower probability of developing the co-infection. Some factors related to comorbidities, such as older age and obesity, draw attention to possible risk factors for hospitalization in this population. Discussing the feasibility of new studies with proposed causal hypotheses that allow directing the research designs toward a more precise answer to these questions is essential
{"title":"Factors associated with COVID-19 infection in People Living with HIV. A case-control study nested in a Colombian cohort","authors":"Juan Carlos Alzate-Angel, Melissa Gutierrez-Gomez, Hector Mueses-Marin, Sandra Valderrama-Beltran, Beatriz Hernandez, Otto Sussmann-Peña, Ernesto Martinez-Buitrago","doi":"10.22354/24223794.1139","DOIUrl":"https://doi.org/10.22354/24223794.1139","url":null,"abstract":"Objective: People living with HIV (PLWH); can be especially vulnerable to the effects of SARS Co V 2 and COVID 19. In this study, we evaluate the factors associated with acquiring COVID 19 and the severity of the infection among PLWH.
 Materials and methods: Through a case-control study nested in a cohort, where cases were PLWH diagnosed with COVID 19; and controls were PLWH without the infection, 476 people were evaluated between May 1, 2020, and February 28, 2021. A univariate analysis was performed with the variables considered candidates. Binary logistic regression models were conducted for the COVID 19 outcome, and among those diagnosed with the infection, regression models for the outcome of hospitalization vs. outpatient treatment.
 Results: Among 238 PLWH diagnosed with COVID 19, receiving integrase inhibitors p < 0.001 (CI 95% 0.27,0.72) or protease inhibitors p 0.034 (CI 95%0.42,0.97) within their antiretroviral regime, was associated with a lower probability of developing COVID 19. 196 (82,35%) of the 238 cases received outpatient treatment, and 42 (17,64%) required hospitalization. In this case, being older than 50 years p < 0.001 (CI 95% 1.8,9.64) and having obesity as a comorbidity p 0.017 (CI 95% 1.34,17.93) increased the possibility of requiring hospitalization, while receiving antiretroviral treatment or having received vaccination against influenza, decreased the likelihood of this outcome.
 Conclusions: There are still many questions regarding whether there is a differential risk of acquiring COVID 19 among PLWH. Antiretroviral treatment with integrase or protease inhibitors; was associated with a lower probability of developing the co-infection. Some factors related to comorbidities, such as older age and obesity, draw attention to possible risk factors for hospitalization in this population. Discussing the feasibility of new studies with proposed causal hypotheses that allow directing the research designs toward a more precise answer to these questions is essential","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alirio Bastidas-Goyes, Eduardo Tuta-Quintero, Faure Yezid Rodríguez, Diego Holguín Riaño, Aldair Chaar Hernández, Lorena García Agudelo, Nicolas Peña Ramos, Carolina Gómez-Ruiz, Juan Giraldo-Vásquez, Doris Pumarejo-Villazón, María Henríquez-Rodríguez, Daniela Álvarez-Araujo, Paola Martínez-Artunduaga, Paola López Morales, Yesid Mantilla-Flórez, Luis F. Reyes
Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.
{"title":"Main clinical variables related to long-term mortality in COVID-19","authors":"Alirio Bastidas-Goyes, Eduardo Tuta-Quintero, Faure Yezid Rodríguez, Diego Holguín Riaño, Aldair Chaar Hernández, Lorena García Agudelo, Nicolas Peña Ramos, Carolina Gómez-Ruiz, Juan Giraldo-Vásquez, Doris Pumarejo-Villazón, María Henríquez-Rodríguez, Daniela Álvarez-Araujo, Paola Martínez-Artunduaga, Paola López Morales, Yesid Mantilla-Flórez, Luis F. Reyes","doi":"10.22354/24223794.1140","DOIUrl":"https://doi.org/10.22354/24223794.1140","url":null,"abstract":"Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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