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The unfortunate events of bowel ischaemia post-Whipple surgery Whipple 手术后肠道缺血的不幸事件
Q4 Medicine Pub Date : 2024-02-27 DOI: 10.29089/paom/177641
Dinesh Alagoo, Harivinthan Sellappan, T. Maiyauen, Guang Hong Ong, Zae Szen Anderson Yong, F. Hayati
Pancreaticoduodenectomy is an extensive procedure with multiple postoperative complications which include surgical site infections, bleeding, delayed gastric emptying, and anastomotic leakage. Among all, postoperative bowel ischaemia is the rarest complication that might be difficult to diagnose and ascertain the cause. If it is left untreated, it may lead to mortality.The aim is to describe the management of bowel ischaemia post-Whipple surgery.A 76-year-old female patient underwent a Whipple procedure for adenocarcinoma of the ampulla which was complicated by postoperative bowel ischemia. A series of investigations, namely endoscopy and imaging, revealed postoperative bowel ischemia beyond the gastro-jejunostomy anastomosis. The patient underwent a series of surgeries and was eventually discharged well. The final histology was consistent with pancreatic cancer and did not require adjuvant chemotherapy.Bowel ischemia in any major surgery occurs due to thrombosis. It is multifactorial including cancer patients, complex reconstruction and major surgery. Identification of thrombosis early in the postoperative follow-up is difficult due to non-specific symptoms, postoperative paralysis of the gastrointestinal tract and modified pain reaction after analgesia. Once diagnosed, the goal is for cessation of thrombosis and fibrinolytic destruction of the thrombus.Bowel ischemia post-Whipple procedure is rare yet dreaded and requires a high level of clinical suspicion. Once diagnosed, an aggressive approach is needed, including relaparotomy and relook surgery. This complication is salvageable with a controlled fistula and adequate nutrition support.
胰十二指肠切除术是一种广泛的手术,术后会出现多种并发症,包括手术部位感染、出血、胃排空延迟和吻合口漏。其中,术后肠缺血是最罕见的并发症,可能难以诊断和确定病因。一名 76 岁的女性患者因胰腺腺癌接受了 Whipple 手术,术后并发肠缺血。一系列检查(即内窥镜检查和影像学检查)显示,术后肠缺血超出了胃空肠吻合口。患者接受了一系列手术,最终康复出院。最终的组织学检查结果与胰腺癌一致,无需进行辅助化疗。任何大手术中的肠缺血都会因血栓形成而发生,其原因是多方面的,包括癌症患者、复杂的重建手术和大手术。由于非特异性症状、术后胃肠道麻痹以及镇痛后疼痛反应的改变,在术后随访的早期发现血栓是很困难的。一旦确诊,目标是停止血栓形成并用纤维蛋白溶解剂破坏血栓。Whipple 术后肠道缺血非常罕见,但却非常可怕,需要临床高度怀疑。一旦确诊,需要采取积极的治疗方法,包括再次剖腹探查术和再次探查手术。通过控制瘘管和适当的营养支持,这种并发症是可以挽救的。
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引用次数: 0
A neuroendocrine tumor in a macroscopically unchanged appendix 大体无变化的阑尾中的神经内分泌肿瘤
Q4 Medicine Pub Date : 2024-02-27 DOI: 10.29089/paom/178458
Wojciech Całka
The intraoperative failure to find a macroscopically visible pathological condition within the appendix or other abnormalities of abdominal organs that could explain clinical symptoms in patients eligible for appendectomy does not prejudge the absence of underlying disease in an apparently healthy appendix.The aim of the study is to highlight the problem of possible hidden pathological conditions in a macroscopically unchanged appendix in patients scheduled for appendectomy.In this article, we present a case of female patient who was qualified to laparoscopic appendectomy due to symptoms of acute appendicitis. Although intra-operatively appendix did not show any pathological signs, histopathological examination revealed neuroendocrine tumor in the organ.This publication describes a case of the removal of a macroscopically unchanged appendix in a patient with clinical and laboratory signs of acute appendicitis. A neuroendocrine neoplasm was histopathologically revealed in the removed appendix. The correct eligibility for appendectomy can present great difficulties even for experienced surgeons. Failure to identify visible abnormalities in the appendix after ruling out other possible causes of clinical symptoms does not prejudge the absence of pathological conditions in this organ.This clinical case shows that the removal of a morphologically normal appendix in a patient eligible for appendectomy, in the absence of other intra-abdominal pathological conditions explaining the clinical signs, is not necessarily a mistake.
本文介绍了一例因急性阑尾炎症状而接受腹腔镜阑尾切除术的女性患者。虽然术中阑尾未显示任何病理征象,但组织病理学检查发现该器官中存在神经内分泌肿瘤。本文描述了一例切除阑尾的病例,患者的阑尾在宏观上没有任何变化,但临床和实验室检查均显示其患有急性阑尾炎。切除的阑尾经组织病理学检查发现存在神经内分泌肿瘤。即使是经验丰富的外科医生也很难正确确定阑尾切除术的资格。本临床病例表明,在没有其他腹腔内病变可解释临床症状的情况下,对符合阑尾切除术条件的患者切除形态正常的阑尾并不一定是错误的。
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引用次数: 0
Anesthesia of a drug-addicted pregnant woman. The current state of knowledge 吸毒孕妇的麻醉。知识现状
Q4 Medicine Pub Date : 2024-02-27 DOI: 10.29089/paom/177290
Paweł Radkowski, Magdalena Wojtczak, Dorota Bartoś-Zdrojewska, Damian Bronisław Truszczyński, Aneta Pruszkowska
Stimulant use during pregnancy is a growing concern, particularly in the USA and Europe. This article explores anesthesia challenges in pregnant patients with substance abuse, optimizing analgesic treatment, and addressing newborns of addicted mothers. Understanding substance use differences is crucial for managing complications and providing long-term care.Investigate anesthesia management, analgesic optimization, and care for newborns of drug-addicted pregnant patients.A comprehensive literature review included articles from PubMed (from January 2009 to December 2021) and relevant Polish, English, and German literature.Opioid use by pregnant women, especially in North America, raises concerns for maternal and child health. The incidence of newborns with withdrawal syndrome is rapidly increasing. Anesthesia challenges arise in managing pregnant patients with addiction, including analgesia optimization and reducing neonatal abstinence syndrome risk. Individualized approaches like regional anesthesia minimize systemic opioids and neonatal withdrawal symptoms. Medication-assisted therapy, e.g., buprenorphine and methadone, reduces illicit opioid use and improves outcomes for mother and baby. Collaborative care among providers is essential.Managing drug-addicted pregnant women requires a multidisciplinary approach. Anesthesia providers play a crucial role in ensuring safety and pain control.
妊娠期间使用兴奋剂的问题日益受到关注,尤其是在美国和欧洲。本文探讨了药物滥用孕妇的麻醉难题、镇痛治疗的优化以及成瘾母亲新生儿的护理问题。了解药物使用的差异对于控制并发症和提供长期护理至关重要。本文对麻醉管理、镇痛优化以及吸毒孕妇新生儿的护理进行了全面的文献综述,包括PubMed(2009年1月至2021年12月)上的文章以及波兰语、英语和德语的相关文献。孕妇使用阿片类药物,尤其是在北美,引起了人们对母婴健康的关注。新生儿戒断综合征的发病率正在迅速上升。在管理有毒瘾的孕妇时,麻醉工作面临挑战,包括优化镇痛和降低新生儿戒断综合征的风险。区域麻醉等个性化方法可最大限度地减少全身阿片类药物和新生儿戒断症状。药物辅助治疗(如丁丙诺啡和美沙酮)可减少阿片类药物的非法使用并改善母婴的预后。医疗服务提供者之间的协作护理至关重要。管理吸毒成瘾的孕妇需要采用多学科方法。麻醉提供者在确保安全和疼痛控制方面发挥着至关重要的作用。
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引用次数: 0
Metformin intake among geriatric patients may predispose to vitamin B12 deficiency: Polish population-based study 老年病人摄入二甲双胍可能导致维生素 B12 缺乏:基于波兰人口的研究
Q4 Medicine Pub Date : 2024-02-27 DOI: 10.29089/paom/176287
Justyna Kacperczyk, Adrian Perdyan, Klaudia Kitala-Tańska, Ewa Kania-Zimnicka, K. Osowiecka, Mateusz Wyszatycki, M. Stompór
Vitamin B12 deficiency is becoming a major problem among geriatric population worldwide. It may contribute to higher prevalence of cognitive impairment and depression, and may occur as a side effect of commonly prescribed anti-diabetic and anti-acid treatments. However, the scale of this phenomenon in Poland remains unknown.We investigated the scale of vitamin B12 deficiency across population of geriatric patients over 70 years old. Additionally, we examined the association between vitamin B12 deficiency, cognitive impairment or depression prevalence, and metformin or proton pump inhibitors intake.Based on the measured vitamin B12 serum level, we divided patients into 3 groups: (1) normal (≥300 pg/mL); (2) borderline (191–300 pg/mL), and (3) low (≤191 pg/mL). The assessment of cognitive impairment or depression was performed by using 5 distinct tests (mini-mental state examination, abbreviated mental test score, clock drawing test, and 4-item or 15-item geriatric depression scale). For statistical analysis, we used χ2 and ANOVA tests.We showed no differences in the frequency of cognitive impairment, depression, and vitamin among characterized groups. Importantly, we found that metformin intake was associated with vitamin B12 deficiency (P = 0.009), contrary to proton pump inhibitor (P = 0.53) and combined these drugs (P = 0.24).We showed a relatively high prevalence of vitamin B12 deficiency across a population of geriatric patients. A preventive vitamin B12 supplementation should be considered when treating, especially geriatric diabetic patients. Due to conflicting results of retrospective studies, prospective clinical trial should be undertaken to describe the association between vitamin B12 deficiency and prevalence of cognitive impairment or depression.
维生素 B12 缺乏症正成为全球老年人群的一个主要问题。它可能会导致认知障碍和抑郁症的发病率升高,也可能是常用的抗糖尿病和抗酸治疗的副作用。我们调查了 70 岁以上老年患者中维生素 B12 缺乏的比例。此外,我们还研究了维生素 B12 缺乏、认知障碍或抑郁症患病率、二甲双胍或质子泵抑制剂摄入量之间的关联。根据测量的维生素 B12 血清水平,我们将患者分为 3 组:(1) 正常(≥300 pg/mL);(2) 边缘(191-300 pg/mL);(3) 低水平(≤191 pg/mL)。认知障碍或抑郁的评估采用 5 种不同的测试(小型精神状态检查、简短智力测验评分、时钟绘画测试、4 项或 15 项老年抑郁量表)。在统计分析中,我们使用了χ2 和方差分析。重要的是,我们发现二甲双胍的摄入与维生素 B12 缺乏有关(P = 0.009),与质子泵抑制剂(P = 0.53)和这些药物的联合使用(P = 0.24)相反。我们发现,在老年糖尿病患者中,维生素 B12 缺乏症的发病率相对较高。在治疗时,尤其是老年糖尿病患者,应考虑预防性补充维生素 B12。由于回顾性研究的结果相互矛盾,因此应开展前瞻性临床试验来描述维生素B12缺乏症与认知障碍或抑郁症发病率之间的关系。
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引用次数: 0
Congenital transsphenoidal meningocele in a newborn: A case report 新生儿先天性经鼻脑膜脑积水:病例报告
Q4 Medicine Pub Date : 2024-02-26 DOI: 10.29089/paom/177338
Azliana Aziz, Yi Wee Lim, Baharudin Abdullah, Zamzuri Idris, Mei Sin Lim
Congenital transsphenoidal meningocele is extremely rare.We present a newborn who was found to have a large midline cystic mass protruding from a cleft palate.Radiological imaging showed a large cerebrospinal fluid mass herniating through a large anterior cranial fossa defect into the sphenoid sinus with extension to the nasal cavity through a cleft palate into the oral cavity.A bifrontal craniotomy and decompression of meningocele with dura repair was performed.The child was discharged healthy postoperatively and on monthly follow-up and subsequently thriving well with improving neurological recovery.
放射成像显示,一个巨大的脑脊液肿块通过一个巨大的前颅窝缺损疝入蝶窦,并通过腭裂延伸至鼻腔,进入口腔。该患儿术后健康出院,每月随访,随后神经系统恢复良好。
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引用次数: 0
Combined right and left sided endocarditis in a hemodialysis patient: A cautionary tale 一名血液透析患者合并左右侧心内膜炎:一个值得警惕的故事
Q4 Medicine Pub Date : 2024-02-02 DOI: 10.29089/paom/176244
Erjola Bolleke (Likaj), E. Likaj, S. Seferi, Kristi Saliaj, Fjorba Mana, S. Dumani, Alma Idrizi
Infective endocarditis is a potentially life-threatening condition, more prevalent among chronic maintenance hemodialysis patients, as opposed to the general population.Combined involvement of both the right and left heart chambers is exceptionally rare.Herein, we present the case of a patient on long-term maintenance hemodialysis with right and left sided infective endocarditis.We discuss potential risk factors leading to the widespread infection and emphasize the importance of an early diagnosis and prompt treatment in yielding better outcomes.The patient was treated successfully by a multidisciplinary team.
感染性心内膜炎是一种可能危及生命的疾病,在长期维持性血液透析患者中比在普通人群中更常见。在这里,我们介绍了一例患有左右侧感染性心内膜炎的长期维持性血液透析患者的病例。我们讨论了导致广泛感染的潜在风险因素,并强调了早期诊断和及时治疗对取得更好疗效的重要性。
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引用次数: 0
Combined right and left sided endocarditis in a hemodialysis patient: A cautionary tale 一名血液透析患者合并左右侧心内膜炎:一个值得警惕的故事
Q4 Medicine Pub Date : 2024-02-02 DOI: 10.29089/paom/176244
Erjola Bolleke (Likaj), E. Likaj, S. Seferi, Kristi Saliaj, Fjorba Mana, S. Dumani, Alma Idrizi
Infective endocarditis is a potentially life-threatening condition, more prevalent among chronic maintenance hemodialysis patients, as opposed to the general population.Combined involvement of both the right and left heart chambers is exceptionally rare.Herein, we present the case of a patient on long-term maintenance hemodialysis with right and left sided infective endocarditis.We discuss potential risk factors leading to the widespread infection and emphasize the importance of an early diagnosis and prompt treatment in yielding better outcomes.The patient was treated successfully by a multidisciplinary team.
感染性心内膜炎是一种可能危及生命的疾病,在长期维持性血液透析患者中比在普通人群中更常见。在这里,我们介绍了一例患有左右侧感染性心内膜炎的长期维持性血液透析患者的病例。我们讨论了导致广泛感染的潜在风险因素,并强调了早期诊断和及时治疗对取得更好疗效的重要性。
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引用次数: 0
Chest wall reconstruction in recurrent breast carcinoma – a case report 复发性乳腺癌的胸壁重建--病例报告
Q4 Medicine Pub Date : 2024-02-01 DOI: 10.29089/paom/175798
Rebecca Xin Yi Choy, Hamidah Mohd Zainal, Mohd Ali Mat Zain
Complex chest wall reconstruction after an oncological resection requires a multidisciplinary approach with the aim of curative resection.The complexity of such reconstruction is challenged by prior reconstructions that limit the options for free tissue transfer and recipient vessels for microsurgical anastomoses.We present a case of an immunocompromised patient with prior breast reconstruction for left breast carcinoma with a pedicled lattisimus dorsi flap who presents with a recurrence to the latissimus dorsi flap requiring a more extensive oncological resection.This resulted in a large chest wall defect that is reconstructed with plating and an anterolateral thigh fasciocutaneous free flap for soft tissue coverage.The radical resection allows for excellent overall survival and better quality of life.
肿瘤切除术后的复杂胸壁重建需要采用多学科方法,以达到治愈性切除的目的。这种重建的复杂性受到先前重建的挑战,因为先前的重建限制了游离组织转移和显微外科吻合受体血管的选择。我们介绍了一例免疫功能低下患者的病例,该患者曾因左侧乳腺癌使用带蒂背阔肌皮瓣进行乳房重建,但背阔肌皮瓣复发,需要进行更广泛的肿瘤切除,导致胸壁大面积缺损,使用钢板和大腿前外侧筋膜游离皮瓣进行软组织覆盖重建。
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引用次数: 0
Chest wall reconstruction in recurrent breast carcinoma – a case report 复发性乳腺癌的胸壁重建--病例报告
Q4 Medicine Pub Date : 2024-02-01 DOI: 10.29089/paom/175798
Rebecca Xin Yi Choy, Hamidah Mohd Zainal, Mohd Ali Mat Zain
Complex chest wall reconstruction after an oncological resection requires a multidisciplinary approach with the aim of curative resection.The complexity of such reconstruction is challenged by prior reconstructions that limit the options for free tissue transfer and recipient vessels for microsurgical anastomoses.We present a case of an immunocompromised patient with prior breast reconstruction for left breast carcinoma with a pedicled lattisimus dorsi flap who presents with a recurrence to the latissimus dorsi flap requiring a more extensive oncological resection.This resulted in a large chest wall defect that is reconstructed with plating and an anterolateral thigh fasciocutaneous free flap for soft tissue coverage.The radical resection allows for excellent overall survival and better quality of life.
肿瘤切除术后的复杂胸壁重建需要采用多学科方法,以达到治愈性切除的目的。这种重建的复杂性受到先前重建的挑战,因为先前的重建限制了游离组织转移和显微外科吻合受体血管的选择。我们介绍了一例免疫功能低下患者的病例,该患者曾因左侧乳腺癌使用带蒂背阔肌皮瓣进行乳房重建,但背阔肌皮瓣复发,需要进行更广泛的肿瘤切除,导致胸壁大面积缺损,使用钢板和大腿前外侧筋膜游离皮瓣进行软组织覆盖重建。
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引用次数: 0
Limy bile syndrome or milk of calcium bile: An unexpected encounter 胆汁乳糜综合征或胆汁钙乳:不期而遇
Q4 Medicine Pub Date : 2024-02-01 DOI: 10.29089/paom/175881
Mitali Madhumita Rath, Rashmi Patnayak, Sambit Kumar Mohanty, Brundaban Nahak, Manoranjan Mohapatra
Limy bile or milk of calcium bile caused due to precipitation of calcium salts in bile is an extremely rare condition of gall bladder, wherein the lumen of gall bladder is filled with chalky white paste like material. Not many cases have been reported till date.In this exceptional case, we tried to correlate the radiological and surgical findings with the histopathology.We hereby present an interesting case of a 59-year-old male who presented with dyspepsia and painful abdomen and was finally diagnosed with limy bile syndrome.The etiology of this rare entity is not fully understood, but it certainly has strong association with impacted stone at the neck of gall bladder and hyperparathyroidism. Females are more commonly affected than males. Patients usually present with complaints of painful abdomen and are commonly diagnosed radiologically, as a radiopacity in gall bladder. Cholecystectomy is the preferred method of treatment for this unusual condition and histopathologically chronic cholecystitis is seen along with presence of slender needle shaped crystals of calcium salts.A thorough evaluation of the clinicoradiological and histopathological findings can sometimes bring to light many uncommon variants of common looking pathologies.
钙盐在胆汁中沉淀而导致的钙化胆汁或钙化胆汁乳是一种极为罕见的胆囊疾病,胆囊腔内充满白垩状白色糊状物。在这个特殊的病例中,我们试图将放射学和外科手术结果与组织病理学相关联。我们在此介绍一例有趣的病例,患者是一名 59 岁的男性,因消化不良和腹部疼痛就诊,最终被诊断为胆汁钙化综合征。这种罕见病的病因尚未完全明了,但肯定与胆囊颈部结石和甲状旁腺功能亢进症有密切关系。女性患者多于男性。患者通常以腹部疼痛为主诉,通常经放射学诊断为胆囊放射性脓肿。胆囊切除术是治疗这种不寻常病症的首选方法,组织病理学检查可见慢性胆囊炎和细长的针状钙盐结晶。
{"title":"Limy bile syndrome or milk of calcium bile: An unexpected encounter","authors":"Mitali Madhumita Rath, Rashmi Patnayak, Sambit Kumar Mohanty, Brundaban Nahak, Manoranjan Mohapatra","doi":"10.29089/paom/175881","DOIUrl":"https://doi.org/10.29089/paom/175881","url":null,"abstract":"Limy bile or milk of calcium bile caused due to precipitation of calcium salts in bile is an extremely rare condition of gall bladder, wherein the lumen of gall bladder is filled with chalky white paste like material. Not many cases have been reported till date.In this exceptional case, we tried to correlate the radiological and surgical findings with the histopathology.We hereby present an interesting case of a 59-year-old male who presented with dyspepsia and painful abdomen and was finally diagnosed with limy bile syndrome.The etiology of this rare entity is not fully understood, but it certainly has strong association with impacted stone at the neck of gall bladder and hyperparathyroidism. Females are more commonly affected than males. Patients usually present with complaints of painful abdomen and are commonly diagnosed radiologically, as a radiopacity in gall bladder. Cholecystectomy is the preferred method of treatment for this unusual condition and histopathologically chronic cholecystitis is seen along with presence of slender needle shaped crystals of calcium salts.A thorough evaluation of the clinicoradiological and histopathological findings can sometimes bring to light many uncommon variants of common looking pathologies.","PeriodicalId":38569,"journal":{"name":"Polish Annals of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Polish Annals of Medicine
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