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Actinomycosis of the pelvis minor involving the ovary, fallopian tube, bladder, rectum, sigmoideum and pelvic wall, mimicking a dispersed neoplastic process 小骨盆放线菌病,累及卵巢、输卵管、膀胱、直肠、乙状结肠和骨盆壁,模拟分散的肿瘤过程
Q4 Medicine Pub Date : 2023-03-15 DOI: 10.29089/paom/162204
D. Zaryjewski, J. Malarkiewicz, Jarosław Ciuńczyk, D. Onichimowski
Introduction. Actinomycosis is a disease caused by anaerobic Gramme positive bacterium Actinomyces israeli. This is a specific inflammation with characteristic pathomorphological changes (sulphur granules), which is accompanied by focuses of fibrosis and the formation of abscesses or fistulas. Actinomycosis may develop in any organ, but the most frequent localization involvs face and neck (63%), lungs (15%) and abdominal cavity, including pelvis minor (22%). Regardless of the observed decrease in the total incidence of actinomycosis in recent years, the number of cases involving the abdominal cavity and pelvis minor localization in the population of women who use intrauterine contraceptive devices (IUD) has increased. Aim. To present, on the basis of own experience, a case of multiorgan actinomycosis within the pelvis minor, as a disease which is too rarely considered in the differentiating diagnostic process in cases of tumour originating from the reproductive organ, urinary tract or alimentary tract. Materials and methods. This article discusses a case of actinomycosis of the pelvis minor, involving the left ovary and tube, bladder, rectum, sigmoideum and pelvic wall. It describes the diagnostic process preceding the surgery, the surgery itself, during which an intraoperative histopathological examination was performed, facilitating the final diagnosis and the application of penicillin therapy. Diagnostic problems involving actinomycosis and a significant role of intraoperative histopathological examination are emphasised. The relationship between pelvic actinomycosis and the application of intrauterine contraceptive device is highlighted. Conclusions. 1. Clinical picture of actinomycosis localized in the reproductive organ may be similar to that of a neoplastic process. 2. In the case of tumours of the pelvis minor of non-specific localization, associated with the application of intrauterine device as a contraceptive method, the possibility of actinomycosis should be considered. 3 Histopathological examination, performed intraoperatively or by biopsy before the surgical procedure, is decisive in the diagnostic process and subsequent treatment. 4. The evaluation of a diagnostic value of bacteriological cultures taken from the uterine cervix to detect anaerobic bacteria in the female population with an increased risk of infection caused by Actinomyces israeli requires further researchperformed on a large group of patients.
介绍放线菌病是由厌氧革兰氏阳性菌以色列放线菌引起的一种疾病。这是一种特殊的炎症,具有特征性的病理形态学变化(硫颗粒),伴有纤维化病灶和脓肿或瘘管的形成。放线菌病可能发生在任何器官,但最常见的部位涉及面部和颈部(63%)、肺部(15%)和腹腔,包括小骨盆(22%)。尽管近年来观察到放线菌病的总发病率有所下降,但在使用宫内节育器(IUD)的女性人群中,涉及腹腔和骨盆轻微定位的病例数量有所增加。目标根据自己的经验,介绍一例小骨盆内多器官放线菌病,这是一种在生殖器官、泌尿道或消化道肿瘤的鉴别诊断过程中很少考虑的疾病。材料和方法。本文讨论一例小骨盆放线菌病,累及左侧卵巢和输卵管、膀胱、直肠、乙状结肠和骨盆壁。它描述了手术前的诊断过程,手术本身,在此过程中进行了术中组织病理学检查,促进了最终诊断和青霉素治疗的应用。强调了放线菌病的诊断问题和术中组织病理学检查的重要作用。强调盆腔放线菌病与宫内节育器应用之间的关系。结论。1.生殖器官放线菌病的临床表现可能与肿瘤过程相似。2.如果是非特异性定位的小骨盆肿瘤,并且使用宫内节育器作为避孕方法,则应考虑放线菌病的可能性。3术中或手术前活检的组织病理学检查对诊断过程和后续治疗具有决定性作用。4.从子宫颈采集的细菌培养物检测以色列放线菌引起的感染风险增加的女性人群中的厌氧细菌的诊断价值的评估需要对大量患者进行进一步的研究。
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引用次数: 0
Prophylactics of postural deformities in children and youth carried out within the teaching environment – experts recommendations 在教学环境中进行的儿童和青少年姿势畸形的预防-专家建议
Q4 Medicine Pub Date : 2023-03-15 DOI: 10.29089/paom/162260
A. Górecki, J. Kiwerski, I. Kowalski, W. Marczynski, J. Nowotny, M. Rybicka, Urszula Jarosz, Maria Suwalska, Wanda Szelachowska-Kluza
Introduction. The Minister of Health, aware of the need to draw up a uniform study, based on up-to-date medical knowledge, which would provide guidelines for educational workers concerning the prophylactics of postural deformities in children and youth, addressed a group of specialists to help arrive at the aforementioned document. All abnormalities of human posture are generally termed posturaldeformities, although this term is not clearly defined and is rather ambiguous. The issue of postural deformities has already been analysed within numerous publications of various natures; still, however, it remains unsolved. The reasons for postural deformities are ample. Apart from the cases when their aetiology stems from congenital deformities or specific diseases, postural deformities usually develop withoutany evident reasons. Factors which lead to adopting an improper posture of the body certainly play a significant role. In time they result in the formation and retention of the habit of adopting an improper posture and thus contribute to the development of deformities.The incidence of postural deformities at the developmental age is assessed approximately at 50–60% of the population, depending on the region. Usually, these are habitual deformities, which to a large degree then contribute to the increase of the number of individuals with postural deformities in the population. Providing care for children and youth with developing or already developed postural deformities is a complex matter. Deformities developed due to a specific cause or those which are much more advanced require specialist treatment, which is beyond the sphere of interest and duties of the teaching environment. The basic tasks of this environment include primary prophylactics, i.e. eliminating these factors which may contribute to the development of deformities as well as promoting a proper body posture. Aim. The aim of this study was to draw up a uniform and up-to-date document which would provide guidelines concerning the prophylactics of postural deformities in children and youth. Methods. Prophylactic activities within the teaching environment are carried out by:director of the teaching institution, teacher/form tutor, physical education teacher, nurse working within the teaching environment/ school hygienist. Conclusions. The aforementioned document drawn up by the specialists is forwarded by the Minister of Health to the Minister of National Education, with the hope that it will prove useful for educational workers in undertaking activities that promote healthy habits amongst children and youth.
介绍。卫生部长意识到有必要根据最新的医学知识编写一份统一的研究报告,为教育工作者提供关于预防儿童和青年姿势畸形的指导方针,他向一组专家发表讲话,以帮助制定上述文件。所有人体姿势的异常通常被称为姿势畸形,尽管这个术语没有明确的定义,而且相当模糊。姿势畸形的问题已经在许多不同性质的出版物中进行了分析;然而,这个问题仍然没有得到解决。造成姿势畸形的原因有很多。除了先天性畸形或特殊疾病引起的病例外,姿势畸形的发生通常没有任何明显的原因。导致采取不正确的身体姿势的因素当然起着重要作用。随着时间的推移,它们会形成并保持采取不正确姿势的习惯,从而导致畸形的发展。根据地区的不同,发育年龄的姿势畸形发生率估计约为人口的50-60%。通常,这些都是习惯性的畸形,这在很大程度上导致了人群中有姿势畸形的人数的增加。为患有发展中或已经发展的姿势畸形的儿童和青少年提供护理是一件复杂的事情。由于特殊原因造成的畸形或那些更严重的畸形需要专门治疗,这超出了教学环境的兴趣和职责范围。这个环境的基本任务包括初级预防,即消除这些可能导致畸形发展的因素,以及促进适当的身体姿势。的目标。这项研究的目的是起草一个统一的和最新的文件,将提供有关预防儿童和青少年姿势畸形的指导方针。方法。教学环境内的预防活动由以下人员开展:教学机构主任、教师/形式导师、体育教师、在教学环境内工作的护士/学校卫生员。结论。卫生部长将上述专家起草的文件转交给国民教育部长,希望该文件对教育工作者开展促进儿童和青年健康习惯的活动有所帮助。
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引用次数: 3
Primary hyperparathyroidism in a 14-year-old boy – a case report 14岁男孩原发性甲状旁腺功能亢进1例报告
Q4 Medicine Pub Date : 2023-02-07 DOI: 10.29089/paom/152262
J. Lewandowska, D. Charemska
Primary hyperparathyroidism (PHPT) is an unusual childhood disease characterized by an excessive secretion of parathyroid hormone (PTH). Its presentation may consist of nonspecific symptoms. Consequently, physicians have trouble diagnosing the disease as they fail to check the level of calcium or PTH.To describe a case of a paediatric patient with primary hyperparathyroidism, who was successfully diagnosed and treated.A 14-year-old boy was admitted to the Paediatric Department with suspected PHPT after performing tests at the Endocrinology Outpatient Clinic, which revealed hypercalcaemia and high PTH level. The ordering of tests was motivated by non-specific symptoms that could indicate PHPT. The ultrasonography, single photon emission computed tomography of the neck and Tc-99m MIBI parathyroid scintigraphy of the neck and upper thorax were performed, which revealed the presence of hypoechogenic structure and focal accumulation of a marker, consistent with the presence of adenoma. The patient was qualified for surgical treatment, which resulted in a resolution of pathological symptoms.Because PHPT is a rare disease among paediatric patients, and is initially characterised by non-specific clinical picture, it is usually diagnosed when advanced organ changes occur. Screening tests, such as calcium and PTH determinations, are also not routinely ordered in this age group. Once the diagnosis is made, the treatment is largely supportive and includes prevention of life-threatening complications.A rare case of a boy with parathyroid adenoma was successfully managed with a multidisciplinary approach combining input from paediatric endocrinologists, radiologists and surgeons.
原发性甲状旁腺功能亢进症(PHPT)是一种不常见的儿童疾病,其特征是甲状旁腺激素(PTH)分泌过多。其表现可能包括非特异性症状。因此,医生在诊断该疾病时遇到了困难,因为他们没有检查钙或甲状旁腺激素的水平。描述一例儿童原发性甲状旁腺功能亢进症患者,该患者被成功诊断和治疗。一名14岁男孩在内分泌门诊进行检查后,因疑似PHPT被送入儿科,检查结果显示他患有高钙血症和高PTH水平。测试的顺序是由可能表明PHPT的非特异性症状引起的。进行了颈部的超声、单光子发射计算机断层扫描和颈部和上胸部的Tc-99m MIBI甲状旁腺闪烁扫描,结果显示存在低回声结构和标志物的局灶性积聚,与腺瘤的存在一致。该患者符合手术治疗条件,病理症状得以缓解。由于PHPT在儿科患者中是一种罕见的疾病,并且最初以非特异性临床表现为特征,因此通常在发生晚期器官变化时诊断。筛查测试,如钙和甲状旁腺激素的测定,也不是这个年龄组的常规要求。一旦确诊,治疗在很大程度上是支持性的,包括预防危及生命的并发症。结合儿科内分泌学家、放射科医生和外科医生的投入,采用多学科方法成功治疗了一例罕见的男孩甲状旁腺腺瘤病例。
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引用次数: 0
Eosinophilic pustular folliculitis in a 90-year-old patient 90岁患者嗜酸性脓疱性毛囊炎
Q4 Medicine Pub Date : 2023-02-07 DOI: 10.29089/paom/156267
M. Cichoń, Beata Wańczyk-Dręczewska, W. Placek, W. Biernat, W. Potocka, Agnieszka Owczarczyk-Saczonek
Eosinophilic pustular folliculitis (EPF), sometimes called Ofuji disease, is a chronic skin disorder of unknown etiology which develops predominantly in elderly man. Clinically it usually presents as itching centrifugally extending papulopustular rash.To present a case of EPF and to raise dermatologists’ awareness of this this dermatosis when dealing with patients who are in higher risk of EPF occurrence.A 90-year-old man presented to the dermatology clinic due to the itching rash that had been present for 3 months. Physical examination of the patient revealed red-brown papulopustules covering trunk and extremities, most severe on the frontal part of thighs. Other possible causative agents of the symptoms were excluded. Histopathological results together with clinical symptoms led us to the final diagnosis of classic EPF.EPF is challenging to diagnose. The disease is very rare, especially in Europe, and clinical and/or histological appearance may mimic other dermatological conditions. The most commonly affected areas are face, back and trunk. EPF is usually classified into three main subtypes: classic, infantile and immunosuppression-associated. There are many viable therapeutic algorithms for the treatment of EPF.Eosinophilic pustular folliculitis should be considered in differential diagnosis of pruritic follicular papulopustular rash affecting elderly men. Histopathological results play a crucial role in the making of final diagnosis.
嗜酸性脓疱性毛囊炎(EPF),有时被称为Ofuji病,是一种病因不明的慢性皮肤病,主要发生在老年人身上。临床上,它通常表现为瘙痒离心性延伸的丘疹性皮疹。介绍一例EPF病例,并提高皮肤科医生在处理EPF发生风险较高的患者时对这种皮肤病的认识。一名90岁的男子因瘙痒皮疹已出现3个月而到皮肤科诊所就诊。患者的身体检查显示,红棕色丘疹覆盖躯干和四肢,最严重的是大腿前部。排除了其他可能引起症状的因素。组织病理学结果和临床症状使我们最终诊断出经典EPF。EPF的诊断具有挑战性。这种疾病非常罕见,尤其是在欧洲,临床和/或组织学表现可能与其他皮肤病相似。受影响最常见的部位是面部、背部和躯干。EPF通常分为三种主要亚型:经典型、婴儿型和免疫抑制相关型。有许多可行的治疗算法可以治疗EPF。嗜酸性脓疱性毛囊炎应被考虑用于鉴别诊断老年男性瘙痒性毛囊丘疹性皮疹。组织病理学结果在最终诊断中起着至关重要的作用。
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引用次数: 0
Impact of omalizumab therapy on the course of COVID-19 in a patient with severe asthma: A case report 奥玛单抗治疗对重症哮喘患者COVID-19病程的影响:1例报告
Q4 Medicine Pub Date : 2023-02-06 DOI: 10.29089/paom/153600
A. Zaleska, A. Radlińska
Various risk factors have been attributed to coronavirus disease 19 (COVID-19) severity. Omalizumab as an immunoglobulin E blocker that enhances anti-viral immunity might be a potential cytokine storm trigger.Our goal was to investigate if the treatment with omalizumab due to severe asthma is a risk factor of severe COVID-19 pneumonia and if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger asthma exacerbation.We report the case of a 65-year-old patient with severe allergic asthma receiving treatment with omalizumab for last 8 months with good results, who in December 2020 was infected with SARS-CoV-2. The patient was not vaccinated against COVID-19 (no vaccine was available at that time), and had comorbidities.COVID-19 course of presented patient was asymptomatic and resolved quickly without the need for hospitalization or asthma exacerbation. There was a slightly worse score on the asthma control questionnaire after COVID-19 resolution (2.1 point vs. 1.5 points) and a threefold increase in eosinophil counts (660 cell/µL vs. 230 cell/µL). However, no wheezing or deterioration in pulmonary function tests were found. A computed tomography of the chest revealed only minor densities of pulmonary parenchyma and thickened walls of bronchi.Omalizumab used in the treatment of severe allergic asthma proved to be safe and beneficial for the course of COVID-19 in the case reported. Simultaneously, SARS-CoV-2 was not a factor for asthma exacerbation.
各种风险因素被归因于冠状病毒病19 (COVID-19)的严重程度。Omalizumab作为增强抗病毒免疫的免疫球蛋白E阻滞剂可能是潜在的细胞因子风暴触发器。我们的目标是调查因严重哮喘而使用omalizumab治疗是否是严重COVID-19肺炎的危险因素,以及严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)是否会引发哮喘恶化。我们报告了一名65岁的严重过敏性哮喘患者,他于2020年12月感染了SARS-CoV-2,接受了奥玛珠单抗治疗,过去8个月效果良好。患者未接种COVID-19疫苗(当时无疫苗可用),并有合并症。本例患者病程无症状且迅速消退,无需住院治疗或哮喘加重。在COVID-19消退后,哮喘控制问卷得分略差(2.1分对1.5分),嗜酸性粒细胞计数增加三倍(660细胞/µL对230细胞/µL)。然而,在肺功能测试中没有发现喘息或恶化。胸部计算机断层扫描显示只有少量肺实质密度和支气管壁增厚。在报告的病例中,用于治疗严重过敏性哮喘的Omalizumab被证明对COVID-19的病程是安全有益的。同时,SARS-CoV-2不是哮喘恶化的一个因素。
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引用次数: 0
Management of postoperative respiratory complication in a child with severe obstructive sleep apnoea syndrome during Covid-19 Covid-19期间1例严重阻塞性睡眠呼吸暂停综合征患儿术后呼吸并发症的处理
Q4 Medicine Pub Date : 2022-11-03 DOI: 10.29089/paom/155079
W. E. Wong, J. Saniasiaya, S. Abu bakar
Coronavirus disease (Covid-19) was first discovered in December 2019 with no signs of conceding to date. Many operations which are regarded as not lifesaving are postponed indefinitely owing to hospital bed shortage as well as to reduce the spread of infection among patients and staff. However, healthcare professionals are thrown down a huge challenge when deciding the timing of treatment for non-life-threatening conditions like severe paediatric obstructive sleep apnoea syndrome (OSAS) with a substantial impact on the development of very young children.To outline management of postoperative respiratory complication in a child with severe obstructive sleep anoea syndrome during Covid-19.We present a case of a major respiratory event requiring reintubation that developed post-adenotonsillectomy in a 3-year-old child with severe OSAS.The child was given close monitoring for 6 h in the post-anaesthetic care unit (PACU) before he was transferred to the general paediatric ward, without PICU admission during his stay in the hospital.Postoperative monitoring at the step-down unit with a high nurse-to-patient ratio appears to be beneficial as it does not compromise the need for close postoperative observation, meanwhile saving costs.
冠状病毒疾病(新冠肺炎)于2019年12月首次被发现,迄今为止没有让步的迹象。由于医院床位短缺以及减少感染在患者和工作人员中的传播,许多被视为无法挽救生命的手术被无限期推迟。然而,医疗保健专业人员在决定对严重儿童阻塞性睡眠呼吸暂停综合征(OSAS)等对幼儿发育有重大影响的无生命危险疾病的治疗时间时,面临着巨大的挑战。概述Covid-19期间一名患有严重阻塞性睡眠呼吸暂停综合征的儿童术后呼吸并发症的处理。我们报告了一例3岁患有严重OSAS的儿童在腺扁桃体切除术后发生的需要重新插管的重大呼吸事件。该儿童在麻醉后护理室(PACU)接受6小时的密切监测,然后被转移到儿科普通病房,住院期间未入住PICU。在护士与患者比例较高的降压单元进行术后监测似乎是有益的,因为它不影响术后密切观察的需要,同时节省了成本。
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引用次数: 0
Retrospective analysis of the methods and complications following the insertion of a PEG tube in children 儿童插入PEG管的方法和并发症的回顾性分析
Q4 Medicine Pub Date : 2022-11-03 DOI: 10.29089/paom/148133
M. Puliński, W. Choiński, Katarzyna Zubik, Julia Talaśka
A long-term intragastric feeding is the indication for percutaneous endoscopic gastrostomy (PEG) placement in a patient. The procedure is performed in children with central nervous system (CNS) disorders, congenital heart defects and neoplastic or metabolic diseases. The PEG placement procedure is most commonly performed by a gastroscopy procedure.The study aimed to retrospectively analyse the methods applied and complications following PEG tube insertion in patients of the Regional Specialist Children's Hospital in Olsztyn, Poland, in the years 2000–2019.A retrospective analysis was conducted of medical histories and records of children qualified for PEG placement procedure. PEG procedure was performed on 48 children: 24 boys and 24 girls. The mean age was 7 years. PEG was inserted in cerebral plasy in 30 patients, congenital defects in 11 and genetic disorders in 7.The reasons for PEG insertion included dysphagia in 30 children, no weight gain in 7, aspiration of gastric contents to the bronchial tree in 6, and feeding difficulties in 10. Two methods for performing PEG insertion procedure were employed: a gastroscopy alone (31 cases) and a laparoscopic-assisted gastroscopy (17). The following complications were: local complications at the incision site (28), PEG dysfunction (13), vomiting (9), sepsis (2), buried bumper syndrome (1), oesophagitis (1), and gastrointestinal fistula (1).The PEG placement procedure is burdened with a significant number of complications, however, they are mainly related to local inflammation or PEG dysfunction.
长期胃内喂养是经皮内镜胃造口术(PEG)安置患者的指征。该手术适用于患有中枢神经系统(CNS)疾病、先天性心脏缺陷和肿瘤或代谢性疾病的儿童。PEG放置手术最常通过胃镜检查进行。该研究旨在回顾性分析2000-2019年波兰Olsztyn地区专科儿童医院患者应用的PEG管插入方法和并发症。回顾性分析符合PEG置入术条件的儿童的病史和记录。48例患儿行PEG手术,男24例,女24例。平均年龄为7岁。应用聚乙二醇植入脑畸形30例,先天性缺陷11例,遗传性疾病7例。插入PEG的原因包括30例患儿吞咽困难,7例患儿体重未增加,6例患儿胃内容物误吸至支气管树,10例患儿进食困难。采用两种方法进行PEG插入手术:单独胃镜检查(31例)和腹腔镜辅助胃镜检查(17例)。以下并发症为切口局部并发症(28例)、PEG功能障碍(13例)、呕吐(9例)、败血症(2例)、埋杆综合征(1例)、食管炎(1例)、胃肠瘘(1例)。PEG放置过程中存在大量并发症,但主要与局部炎症或PEG功能障碍有关。
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引用次数: 0
Abscess of the piriformis muscle in a 14-year old boy - a transrectal drainage method under transabdominal ultrasound guidance 14岁男孩梨状肌脓肿——经腹部超声引导下经直肠引流法
Q4 Medicine Pub Date : 2022-10-28 DOI: 10.29089/paom/154893
Katarzyna Szymak, M. Puliński, W. Choiński, Michał Szostawicki
Sciatica is a common reason for a medical consultation throughout the population. Piriformis pyomyositis is a rare cause of these symptoms. Its probable etiology is transient bacteraemia co-existing temporarily with a muscle injury.The aim of the study is to present a method for treating a piriformis muscle abscess with transabdominal ultrasound-guided transrectal drainage.A 14-year old boy, previously healthy, was admitted with symptoms of sciatica that appeared after intense physical exertion. Laboratory tests revealed elevated inflammatory parameters and positive blood culture results indicating Staphylococcus aureus. Antibiotic therapy was implemented. MRI of the small pelvis revealed a forming abscess of the right piriformis muscle. On day 6 of the antibiotic therapy, in the absence of improvement, it was decided to perform transrectal drainage under ultrasound guidance. Clinical improvement was achieved, and the inflammatory parameters decreased.Co-existence of sciatica symptoms and signs of an inflammatory condition should prompt the consideration of piriformis pyomyositis. The mainstay of treatment for piriformis pyomyositis is antibiotic therapy. The abscess formation reduces its effectiveness, which necessitates surgical intervention. The authors present the application of transrectal drainage under transabdominal ultrasound guidance as the shortest route of abscess evacuation.Transrectal drainage of piriformis pyomyositis is an effective and safe method. Concomitant use of ultrasound scans reduces the patient’s exposure to ionising radiation. However, the widespread use of this method requires more in-depth research and broadened experience.
坐骨神经痛是全民就医的常见原因。梨状肌化脓性肌炎是引起这些症状的罕见原因。其可能的病因是暂时性菌血症和肌肉损伤并存。本研究的目的是提出一种经腹部超声引导经直肠引流治疗梨状肌脓肿的方法。一名14岁男孩此前健康,因剧烈体力消耗后出现坐骨神经痛症状入院。实验室检测显示炎症参数升高,血液培养结果呈阳性,表明金黄色葡萄球菌。实施了抗生素治疗。小骨盆的核磁共振成像显示右侧梨状肌脓肿正在形成。在抗生素治疗的第6天,在没有改善的情况下,决定在超声引导下进行经直肠引流。临床症状得到改善,炎症参数降低。坐骨神经痛症状和炎症症状的共同存在应促使考虑梨状肌化脓性肌炎。梨状肌化脓性肌炎的主要治疗方法是抗生素治疗。脓肿的形成降低了它的有效性,因此需要手术干预。作者介绍了经腹部超声引导下经直肠引流作为脓肿最短引流途径的应用。梨状肌化脓性肌炎经直肠引流是一种安全有效的治疗方法。同时使用超声波扫描可以减少患者暴露在电离辐射下的风险。然而,这种方法的广泛使用需要更深入的研究和更广泛的经验。
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引用次数: 0
Phoenixin plasma concentration in heart failure with reduced ejection fraction patients 凤凰新在心力衰竭伴射血分数降低患者血药浓度中的作用
Q4 Medicine Pub Date : 2022-10-05 DOI: 10.29089/paom/150551
Tomasz Zemleduch, K. Ratajczyk, J. Majewska, Piotr Kimla, B. Kudliński, K. Marek-Bukowiec, E. Straburzyńska-Migaj
Heart failure (HF) nowadays in western countries is an immense problem largely due to its social impact as well as an economic burden. A widely accepted biomarker-based strategy to establish prognosis and predict re-hospitalization events in HF is lacking. Currently, besides natriuretic peptides and cardiac troponins, a variety of molecules are being studied. Phoenixin (PNX) is a neuropeptide mainly involved in the regulation of gonadotropin secretion. Recently, a significant cardioprotective effect of PNX was reported.The aim of this study was to measure PNX plasma concentration in a group of HF with reduced ejection fraction (HFrEF) patients and to compare it to levels found in HF-negative participants.A group of 74 HFrEF patients and a control group consisting of 40 participants without systolic or diastolic myocardial dysfunction were studied. Each individual underwent anthropometric measurements, laboratory testing, clinical and echocardiographic examination. To evaluate PNX plasma concentration, an immunoenzymatic assay (ELISA) was performed.PNX plasma concentration in the HFrEF group was not statistically different than in the control group. No significant correlation between PNX level and age, sex, BMI, HF etiology, diabetes or atrial fibrillation presence was found. PNX concentration correlated positively with total and LDL cholesterol blood levels in HFrEF patients. A negative correlation was found with creatinine in HFrEF, uric acid and triglycerides levels as well as AlAT activity in the control group.There is no significant difference in PNX plasma concentration between HF and non-HF individuals. PNX role in cardiovascular disease requires further investigation.
心力衰竭(HF)目前在西方国家是一个巨大的问题,主要是由于它的社会影响和经济负担。目前缺乏一种广泛接受的基于生物标志物的策略来建立心衰的预后和预测再住院事件。目前,除了利钠肽和心脏肌钙蛋白外,还有多种分子正在研究中。凤凰素(phoenix xin, PNX)是一种主要参与调节促性腺激素分泌的神经肽。最近,有报道称PNX具有显著的心脏保护作用。本研究的目的是测量一组HF伴射血分数降低(HFrEF)患者的PNX血浆浓度,并将其与HF阴性参与者的水平进行比较。研究了74名HFrEF患者和40名无收缩或舒张心肌功能障碍的对照组。每个人都接受了人体测量、实验室测试、临床和超声心动图检查。采用免疫酶法(ELISA)评价PNX血药浓度。HFrEF组PNX血药浓度与对照组比较差异无统计学意义。PNX水平与年龄、性别、BMI、HF病因、糖尿病或房颤无显著相关性。PNX浓度与HFrEF患者血液中总胆固醇和低密度脂蛋白胆固醇水平呈正相关。在对照组中,HFrEF、尿酸和甘油三酯水平以及AlAT活性与肌酐呈负相关。HF与非HF患者PNX血药浓度无显著差异。PNX在心血管疾病中的作用有待进一步研究。
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引用次数: 0
The forgotten bomb: Ramussens’s aneurysm 被遗忘的炸弹:Ramussens的动脉瘤
Q4 Medicine Pub Date : 2022-09-20 DOI: 10.29089/paom/151915
Hüseyin Akkaya, Okan Dilek, Sinan Sözütok, H. Onan, Cengiz Yılmaz, Ümit Çelik, B. Gülek
Rasmussen’s aneurysm is an inflammatory pseudoaneurysmal dilatation of a branch of the pulmonary artery adjacent to the tuberculous cavity. It often presents with hemoptysis resulting from its rupture. Massive hemoptysis seen in giant aneurysms is a rare but life-threatening complication of cavitary tuberculosis.In this case, we aimed to present a case of giant rasmussen aneurysm that did not bleed and was diagnosed incidentally.In this article, we present a female patient who was surprisingly diagnosed with Rasmussen’s aneurysm during her follow-up after having been admitted to our emergency department due to diabetic ketoacidosis, fever, and shortness of breath and not responding to tuberculosis treatment. She was diagnosed using multi-detector computed tomography angiography and underwent embolization with a percutaneous thrombin injection. On the day after the procedure, thoracotomy had to be performed because the pseudoaneurysm continued to show contrast enhancement on imaging. She was successfully treated with surgery.Although pulmonary artery aneurysms are rare, it should be kept in mind that they may be related to tuberculosis. Pulmonary artery aneurysms are large asymptomatic and can reach gigantic dimensions as in this case. Rupture of an aneurysm of this size can be predicted to be mortal. Percutaneous thrombin injection can be used for treatment. However, percutaneous treatment may recur in large aneurysms, in which case surgical treatment is curative.Rasmussen aneurysm is very rare, and when it is asymptomatic, its diagnosis may be delayed until it reaches gigantic dimensions. Contrast-enhanced thorax computed tomography and especially multi-detector computed tomography angiography are helpful in diagnosis.
拉斯穆森动脉瘤是结核腔附近肺动脉分支的炎症性假动脉瘤样扩张。它经常表现为破裂引起的咳血。巨大动脉瘤中的大量咳血是空洞性肺结核的一种罕见但危及生命的并发症。在这种情况下,我们的目的是提出一个巨大的拉斯穆森动脉瘤,没有出血,是偶然诊断的。在这篇文章中,我们介绍了一名女性患者,她在因糖尿病酮症酸中毒、发烧和呼吸急促入院后,在随访中被意外诊断为拉斯穆森动脉瘤,但对结核病治疗没有反应。她通过多探测器计算机断层扫描血管造影术得到诊断,并接受了经皮凝血酶注射栓塞。手术后的第二天,由于假性动脉瘤在影像学上继续表现出对比增强,不得不进行开胸手术。她成功地接受了手术治疗。尽管肺动脉瘤很少见,但应该记住,它们可能与肺结核有关。肺动脉瘤是无症状的大动脉瘤,在这种情况下可以达到巨大的尺寸。这种大小的动脉瘤破裂可以预测是致命的。经皮凝血酶注射可用于治疗。然而,经皮治疗可能会在大动脉瘤中复发,在这种情况下,手术治疗是有效的。拉斯穆森动脉瘤是非常罕见的,当它没有症状时,它的诊断可能会推迟到它达到巨大的尺寸。胸部计算机断层造影,特别是多探测器计算机断层造影血管造影术有助于诊断。
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Polish Annals of Medicine
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