Journal of Oral and Maxillofacial Pathology最新文献

Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology. Histopathology, along with immunohistochemistry, is needed for its confirmative diagnosis. We present a 28-year-old female with slow-growing, painless palatal swelling diagnosed as clear cell myoepithelioma on histopathology and immunohistochemistry.

Merkel cells are perceived as tactile receptors within skin and oral mucosa containing abundant intermediate filaments but lacking characteristic condensation of tonofilaments, hence are also referred to as non-keratinocytes. Merkel cell carcinomas (MCCs) are primary aggressive neuroendocrine neoplasms occurring in elderly individuals. Toker in 1972 reported MCC of skin pointing towards sweat glands as the source of origin which was later rectified by Tang with the aid of ultrastructural studies as Merkel cells to be a lineage of such tumours. Normally, Merkel cells are abundant in the gingiva and vermillion border of the lip and thus these are the common sites for this neoplasm. Histopathologically, MCC mimics varied other carcinomas, hence requiring a thorough diagnostic protocol. We present a case of challenging histopathology which on immunohistochemical analysis with a unique cytokeratin profile and neurofilament staining pattern helped in reaching a definitive diagnosis.

Context: Platelet concentrates are rich in growth factors that assist in regenerative medicine to promote healing and tissue regeneration. Similarly, partially demineralized tooth is a storehouse of many growth factors, assisting in bone regeneration. Hence, the present study aimed to quantify the release of growth factors from different platelet concentrates individually and when mixed with a partially demineralized tooth matrix.

Method: Human growth factors such as bFGF, EGF, PDGF-AB, TGF-beta-1, and VEGF-A present in platelet-rich fibrin and injectable platelet-rich fibrin from young and old male and female donors were quantified separately. Then these platelet concentrates were then mixed with a partially demineralized tooth matrix, which was powdered using a Smart Dentin Grinder. An enzyme-linked immunosorbent assay was used for the quantification of growth factors.

Results: The release of growth factors, such as platelet-rich fibrin and injectable platelet-rich fibrin, was not statistically significant; however, it was significantly greater when i-PRF was mixed with a partially demineralized tooth matrix.

Conclusion: The study revealed that the expression of growth factors was significantly greater when a partially demineralized tooth matrix was mixed with injectable platelet-rich fibrin than when combined with platelet-rich fibrin.

Background: Gingiva is a keratinised mucosa akin to the skin and is exposed in all modalities of treatment of oral cancer. Acquired lymphangiectasia are acquired dilatations of lymphatic channels secondary to an external cause. They are extremely rare in the oral cavity despite that oral cancers are treated with different treatment modalities.

Methods: The archives of the Oral and Maxillofacial Pathology Department of our institute were retrospectively reviewed from 2001 to 2021. Of the 9566 cases of oral biopsies, 4596 were confirmed cases of oral cancer including salivary gland carcinoma. These cases were followed up for the presence of post-neoplastic and post-therapeutic gingival lesions.

Results: Of the 4596 patients, <10% patients reported recurrence or new primary of squamous cell carcinoma in the gingiva. Two patients were histopathologically diagnosed with acquired lymphangiectasia of gingiva after 12 years following surgery and radiation therapy as treatment for oral squamous cell carcinoma and mucoepidermoid carcinoma, which has been described in our report for the first time in the literature.

Conclusion: Even though acquired lymphangiectasia of gingiva is very rare, lymphatic malformations should be included in the clinical differential diagnosis of post-therapeutic gingival proliferative pathologies in order to ensure appropriate treatment and prevent over-diagnosis of this benign condition.

Background and objectives: Globally, the prevalence of diabetes and dental caries has been soaring high in recent times. There is a constant effort in the scientific community to develop a reliable and economic early predictor which can serve the purpose of mass screening of genetically vulnerable populations. The present study attempts to evaluate the different types of lip prints and finger prints in diabetes mellitus and dental caries and to see association between the most common diseases (diabetes mellitus and dental caries) if any.

Materials and methods: Study subjects included 100 subjects (50 uncontrolled Type II diabetes mellitus patients and 50 healthy controls) in the age group of 30-80 years among the population of Lucknow. Lip prints were obtained using lipstick and cellophane paper, analysed, and classified using Suzuki and Tsuchihashi's classification. Finger prints were obtained using inkpad, analysed, and classified using Henry's system of classification.

Results: We found loop-type fingerprints and type IV lip prints associated with diabetic patients. Non-diabetics showed loop-type fingerprints and type I lip prints. We found increased dental caries incidence (DMFT scores) in diabetics. Diabetic subjects with caries showed loop fingerprints, which reiterated our earlier findings but are not associated with type IV lip prints. Non-diabetics with caries showed arch fingerprints, but they are not associated with type I lip prints. We found that DMFT scores that we used to assess caries did not associate well with lip prints.

Conclusion: The results from our study strongly suggest that dermatoglyphics can be used as a non-invasive technique to mass screen for diabetes as well as dental caries as both diseases are predominantly associated with loop-type fingerprints. Type IV lip prints could be used to screen for diabetes, but no association of lip prints was seen in patients with caries.

Focal osteoporotic bone marrow defects (FOBMDs) of jaws are rare and usually discovered as an incidental radiographic finding. They present as a poorly demarcated radiolucency affecting the posterior mandible of middle-aged women with pathogenesis remaining unknown. A 60-year-old female patient had visited our dental college for routine dental checkup and oral prophylaxis. Her radiograph revealed a well-defined radiolucency in the left mandibular posterior region as an incidental finding. Clinical examination revealed a diffuse swelling in the above-mentioned region which the patient had not noticed. The patient gave a history of trauma in the same region almost 20 years back. Incisional biopsy was performed. Microscopic examination revealed multiple bits of fatty fibro cellular tissue resembling the bone marrow with aggregates of blood cells. A diagnosis of FOBMD was given. FOBMD, although rare, should be included in differential diagnosis of the radiolucent lesions of the jaws.

Hand, foot and mouth disease (HFMD) is a viral highly contagious disease affecting mostly infants and children and occasionally adults. It has become a significant public health problem because of frequent outbreaks and rise in its incidence, severity and fatal complications in Southeast Asian countries in the last few decades. India had experienced a sudden resurgence of HFMD recently in the year 2022. The clinical course of HFMD is mainly mild and self-limiting with recovery within 1-2 weeks, but in few patient's, severe form of infection has been reported. In this report, we present the case of a 4-year-old boy presenting with HFMD.

Amidst worldwide reports of adverse oral lesions subsequent to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, the current systematic review planned to determine the prevalence of adverse oral events in adult individuals (≥18 years) after SARS-CoV-2 vaccination, emphasizing upon the type and dose of vaccine, time of onset, and underlying pathophysiology. The registered protocol (PROSPERO CRD42023421307), conforming with PRISMA guidelines, included an all-inclusive literature search through online databases, consisting of Scopus, PubMed/MEDLINE, Web of Science, Lilacs, Livivo, and PROSPERO, completed on 2 May 2023, followed by assessment of risk of bias by Joana Briggs Institute Evaluation Checklist. Due to the paucity of literature, case reports and case series were included. Self-reported lesions were excluded. Qualitative synthesis employing Microsoft Excel software 2019 revealed low prevalence (43 subjects) from 26 case reports and two case series. There were multiple erosive oral ulcers on gingiva, palate, burning pain in the mouth, xerostomia, tongue fissuring and glossitis, palatal petechiae, diffuse erythematous lesions and loss of smell (16.2%), primary herpetic gingivostomatitis (21%), oral lichen planus (16.2%), Stevens-Johnson syndrome (6.9%), Bell's palsy in four cases where two cases were Guillain-Barré syndrome (9.3%), erythema multiforme (11.6%), pemphigus (4.6%), idiopathic thrombocytopenic purpura (6.9%), unilateral hypoglossal nerve palsy (4.6%), and trigeminal neuralgia (2.3%). Maximum cases (22 subjects) presented oral lesions after Pfizer (BNT162b2) SARS-CoV-2 vaccine. No association was found between the vaccine type and dose with oral side effects. Dentists must be aware of the oral adverse effects after coronavirus disease 2019 vaccination to better understand the pathogenesis and the risk factors associated with such reactions.

Identification of cancer stem cells (CSCs), their multilineage potential, and their ability of self-renewal have revolutionised the current concepts of cancer treatment. The suspected role of CSCs in cancer initiation, progression and relapse with the observed resistance to conventional cancer treatments has led to the development of more specific and targeted therapies. Identification of the properties of stem cells (SCs) and their potential for localisation in cancer has made targeted anti-cancer treatment possible by incorporating some modifications into these SCs. The same concept has been applied to the treatment strategy for head and neck squamous cell carcinoma (HNSCC) to control the relapse and improve the mortality rates in patients. This review aims to discuss the role of CSCs in the course and relapse of HNSCC, various surface markers for their identification and SC-targeted therapy options for the treatment of HNSCC, with a highlight on the advantages, shortcomings, opportunities and challenges to SC therapy in head and neck squamous cell carcinoma, treatment and scope for future research.

Background: Trace elements are the important components that play a crucial role in various functions of the human body at cellular and molecular levels. Considering the role of the trace elements in precancerous and cancerous conditions, estimation of their levels in these conditions could aid in understanding the disease process and progression. The purpose of this study is to determine the alteration in salivary electrolyte concentration of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients to correlate the variations with the severity and biological behaviour.

Material and method: A total of 70 subjects were included in this study, and they were divided into three groups: patients with OSCC (30), OPMDs (30) and apparently healthy individuals (10). An informed consent was obtained, following which blood and saliva samples were collected from the participants. Salivary and serum levels of copper, zinc, lead, cadmium, calcium and magnesium were measured and compared between the groups.

Results: The levels of biochemical elements in both serum and saliva were in perfect correlation. The amount of all the estimated metallic ions was found to be significantly (P 0.001) increased in OSCC followed by OPMDs and normal mucosa. The levels of copper, cadmium and magnesium were gradually increased in increasing grades of OSCC (P 0.001).

Conclusion: Salivary trace element levels could possibly have diagnostic significance in the early evaluation of OPMDs and OSCC as well. Increased levels of these elements might be used as a marker of disease progression and predictor of prognosis.