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An enigmatic combined tumour of oral malignant melanoma and oral squamous cell carcinoma - A rare case report. 口腔恶性黑色素瘤和口腔鳞状细胞癌的神秘合并肿瘤--罕见病例报告。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_330_22
S Renuga, N S Sahana, G Suganya, Meghashyama Kulkarni

Combined tumours are those composed of two benign tumours or a benign and malignant tumour or two malignant tumours occurring within the same tumour population. The incidence of combined tumours is very rare. Due to the rarity of these tumours, their biological behaviour remains unlashed. Incisional biopsy of a 48 years old female patient with single, diffuse tumour mass in the oral cavity showed combined tumour or collision tumour of malignant melanoma and squamous cell carcinoma. This was confirmed with immunohistochemistry study. The incidence of combined tumour of malignant melanoma and squamous cell carcinoma in oral cavity is extremely rare. To the best of our knowledge based on the previous literature records, this is the first case report of its kind where there is incidence in the human oral cavity.

合并肿瘤是指由两个良性肿瘤、一个良性肿瘤和一个恶性肿瘤或两个恶性肿瘤组成的同一肿瘤群。合并肿瘤的发病率非常罕见。由于这类肿瘤非常罕见,其生物学行为仍未被揭示。一名 48 岁的女性患者口腔内有单个弥漫性肿瘤肿块,切开活检显示其为恶性黑色素瘤和鳞状细胞癌的合并瘤或碰撞瘤。免疫组化研究证实了这一点。口腔恶性黑色素瘤和鳞状细胞癌合并肿瘤的发病率极为罕见。据我们所知,根据以往的文献记录,这是第一例在人类口腔中发生的同类病例报告。
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引用次数: 0
Squamous odontogenic tumour-like proliferation in a maxillary dentigerous cyst - An unusual finding. 上颌牙源性囊肿中的鳞状牙源性肿瘤样增生--一个不寻常的发现。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_51_24
Ngairangbam Sanjeeta, Brajbushan Mall, Sumita Banerjee, Praveen B Reddy

Squamous odontogenic tumour-like proliferations (SOTLPs) in the wall of odontogenic cysts are rare occurrences. Due to the histopathological similarity of these proliferations to neoplasms, such as squamous odontogenic tumour, intraosseous well-differentiated squamous cell carcinoma, and acanthomatous ameloblastoma, their correct elucidation is of paramount importance to avoid unnecessary and unwanted treatment. SOTLPs are uncommon in dentigerous cysts and rare in those that occur in the maxilla particularly the anterior region. This paper presents a case of maxillary dentigerous cyst involving 33 and a mesiodens in a 32 year old male which on histopathological examination showed SOTLPs in a dentigerous cyst.

牙源性囊肿壁上的鳞状牙源性肿瘤样增生(SOTLPs)很少见。由于这些增生与鳞状牙源性肿瘤、骨内分化良好的鳞状细胞癌、棘细胞瘤等肿瘤在组织病理学上相似,因此正确地阐明这些增生对避免不必要的治疗至关重要。SOTLPs在牙源性囊肿中并不常见,在发生于上颌骨尤其是前牙区的牙源性囊肿中更是罕见。本文介绍了一例上颌齿槽囊肿病例,患者为一名32岁男性,涉及33颗牙和一颗牙间质,组织病理学检查显示齿槽囊肿中存在SOTLPs。
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引用次数: 0
Molecular expression of Forkhead Box C2 gene (FOXC2) and Prospero homeobox gene (PROX-1) in oral squamous carcinoma and their correlation with clinicopathological parameters: A prospective cohort study. 口腔鳞癌中叉头盒 C2 基因(FOXC2)和 Prospero homeobox 基因(PROX-1)的分子表达及其与临床病理参数的相关性:前瞻性队列研究。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_394_23
Georgia Benitha, Pratibha Ramani, Selvaraj Jayakumar, Karthikeyan Ramalingam

Background: Forkhead box C2 gene (FOXC2) acts as an epithelial-mesenchymal transition (EMT) inducer while Prospero homeobox 1 gene (PROX-1) function as a regulator of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma (OSCC). It is presumed that PROX-1 has both tumour-suppressive and oncogenic effects. The main aim of this study is to evaluate the role of PROX-1 and FOXC2 in the invasion and progression of OSCC cases and to correlate their expression with various histopathological parameters.

Materials and methods: A prospective cohort study was conducted in a total sample size of 52 OSCC tissues and histologically tumour-free margins of 20. mRNA expression and protein levels of FOXC2 and PROX-1 were evaluated using real-time PCR and sandwich enzyme-linked immunosorbent assay techniques. Chi-square analysis and correlation analysis were done. Kaplan-Meier analysis evaluated the survival rate.

Results: Mean Ct values of FOXC2 were 1.915 ± 0.519 and PROX-1 was 0.061 ± 0.173. There was a significant 2-fold increase in the FOXC2 expression and a 0.5-fold decrease in the PROX-1 expression in OSCC tissue. Increased levels of FOXC2 protein and decreased levels of PROX-1 with a mean difference of 1.64 ± 0.73 ng/ml and 1.27 ± 0.33 ng/ml were observed in OSCC compared to histologically tumour-free margins. A significant positive correlation was found between the FOXC2 expression and clinicopathological parameters such as staging, perineural invasion (PNI) and lymphovascular invasion (LVI) whereas PROX-1 showed a significant negative correlation with histopathological parameters such as staging, PNI, LVI and tumour staging. There was a significant positive correlation between the PROX-1 and histologically tumour-free margins in disease-free survival patients (P-value = 0.03).

Conclusion: FOXC2 and PROX-1 expressions were correlated with lymphovascular invasion, OSCC tumour staging and PNI. Thus, FOXC2 and PROX-1 could be possible therapeutic targets in the treatment of OSCC that can inhibit the EMT in OSCC and thereby favouring a better prognosis.

背景:叉头盒 C2 基因(FOXC2)是上皮-间质转化(EMT)的诱导因子,而 Prospero homeobox 1 基因(PROX-1)则是口腔鳞状细胞癌(OSCC)淋巴管生成和血管生成的调节因子。据推测,PROX-1 具有抑制肿瘤和致癌的双重作用。本研究的主要目的是评估 PROX-1 和 FOXC2 在 OSCC 病例的侵袭和进展中的作用,并将它们的表达与各种组织病理学参数相关联:采用实时 PCR 和夹心酶联免疫吸附试验技术评估 FOXC2 和 PROX-1 的 mRNA 表达和蛋白水平。进行了卡方分析和相关分析。Kaplan-Meier分析评估了存活率:结果:FOXC2的平均Ct值为1.915 ± 0.519,PROX-1为0.061 ± 0.173。在 OSCC 组织中,FOXC2 的表达量明显增加了 2 倍,PROX-1 的表达量减少了 0.5 倍。与组织学上无肿瘤的边缘相比,在OSCC中观察到FOXC2蛋白水平升高,PROX-1水平降低,平均差异为1.64 ± 0.73 ng/ml和1.27 ± 0.33 ng/ml。研究发现,FOXC2 的表达与临床病理参数(如分期、神经周围侵犯(PNI)和淋巴管侵犯(LVI))呈显著正相关,而 PROX-1 与组织病理参数(如分期、PNI、LVI 和肿瘤分期)呈显著负相关。在无病生存患者中,PROX-1与组织学无肿瘤边缘之间存在明显的正相关性(P值=0.03):结论:FOXC2和PROX-1的表达与淋巴管侵犯、OSCC肿瘤分期和PNI相关。因此,FOXC2和PROX-1可能是治疗OSCC的治疗靶点,可抑制OSCC的EMT,从而改善预后。
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引用次数: 0
Oral squamous cell carcinoma: A 26 years institutional cross-sectional study. 口腔鳞状细胞癌:一项长达 26 年的机构横断面研究。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_38_24
Dipak D Ghatage, Ashwini G Kendre, Devendra H Palve, Akshay Dhobley, Divya Ghodichor, Akhil Lakawath

Context: The variance in the prevalence of oral squamous cell carcinoma (OSCC) around the world has been associated with a number of sociocultural traits, significant regional variations in risk factors, variations in data gathering, and the degree of health service development in different populations. Here, we undertake a 26 years institutional review and analysis of OSCC cases.

Aim: To evaluate and analyse 26 years Institutional Data of OSCC.

Settings and design: Department of Oral and Maxillofacial Pathology's archives, Government Dental College and Hospital, Nagpur, Maharashtra, and observational cross-sectional study.

Methods and material: This study examines instances of OSCC that were histologically diagnosed between 1997 and 2022. All information pertaining to cases of OSCC was obtained from the departmental archives.

Statistical analysis used: Data tabulated and then subjected to descriptive statistical analysis with the SPSS statistical software.

Results: The total number of the patients included 1508 (69.6%) males and 660 (30.4%) females, whose age ranged from the second decade to the tenth decade of life with a mean age of 55.5 years with a range of 20-91 years. The incidence was the highest in the fifth and sixth decades (n = 603, 27.8% and n = 572, 26.4%), respectively. The left buccal mucosa recorded the maximum number of cases (left buccal mucosa 559, 25.8%). There were 1405 (64.8%) cases of well-differentiated SCC, 301 (13.9%) cases of moderately differentiated SCC, and 51 (2.4%) cases of poorly differentiated SCC.

Conclusions: The overall incidence and prevalence of OSCC can be estimated using baseline epidemiological data from our institution.

背景:世界各地口腔鳞状细胞癌(OSCC)发病率的差异与许多社会文化特征、风险因素的显著地区差异、数据收集的差异以及不同人群的医疗服务发展程度有关。在此,我们对26年来的OSCC病例进行了机构回顾和分析。目的:评估和分析26年来的OSCC机构数据:马哈拉施特拉邦那格浦尔政府牙科学院和医院口腔颌面病理系档案,观察性横断面研究:本研究调查了 1997 年至 2022 年间经组织学诊断的 OSCC 病例。与 OSCC 病例有关的所有信息均来自科室档案:数据制成表格,然后使用 SPSS 统计软件进行描述性统计分析:患者总人数中包括 1508 名男性(69.6%)和 660 名女性(30.4%),他们的年龄从二十岁到十岁不等,平均年龄为 55.5 岁,年龄范围为 20-91 岁。第五个十年和第六个十年的发病率最高,分别为 603 例(27.8%)和 572 例(26.4%)。左侧口腔黏膜的病例数最多(左侧口腔黏膜 559 例,占 25.8%)。分化良好的 SCC 有 1405 例(64.8%),中度分化的 SCC 有 301 例(13.9%),分化不良的 SCC 有 51 例(2.4%):结论:利用本院的基线流行病学数据可以估算出 OSCC 的总体发病率和流行率。
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引用次数: 0
Paediatric oral hyaline ring granuloma associated with an impacted tooth and its management preserving the tooth germ: A case report. 与撞击牙相关的小儿口腔透明环肉芽肿及其保留牙胚的处理方法:病例报告。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_391_21
Jaspreet Kaur Deo, Pravesh Mehra, Shailaja Shukla

Oral hyaline ring granuloma is an unusual granulomatous lesion affecting the jaws characterized by the presence of numerous eosinophilic rings with multinucleated giant cells. The lesion can be of central or peripheral variety, caused by the impaction of foreign particles in the oral cavity. While literature describes this lesion in association with dentures, carious teeth and extraction socket, this paper reports the first case of an oral hyaline ring granuloma associated with an impacted premolar tooth and its surgical management.

口腔透明环肉芽肿是一种影响颌骨的不常见肉芽肿病变,其特征是存在大量带有多核巨细胞的嗜酸性环。这种病变可以是中心性的,也可以是周围性的,由口腔中的异物颗粒嵌塞引起。文献描述这种病变与假牙、龋齿和拔牙窝有关,本文则报告了首例与受撞击的前磨牙有关的口腔透明环肉芽肿及其手术治疗。
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引用次数: 0
Clinical management of bullous pemphigoid-The importance of cytology in diagnosis. 大疱性类天疱疮的临床治疗--细胞学诊断的重要性。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_544_23
Preethi Ramesh, C V Divyambika, Aravind S Warrier, Leena Dennis Joseph

Bullous pemphigoid (BP) is a common immune-mediated blistering disorder with predominant skin involvement and occasionally oral manifestations. Vesiculobullous lesions of the oral mucosa present with similar clinical features, and hence arriving at a clinical diagnosis is aided by a valuable chairside investigation, exfoliative cytology. Cytology done in the present case ruled out pemphigus because of the absence of Tzanck cells in the smear. Biopsy and direct immunofluorescence further confirmed the diagnosis of BP. Treatment initiated with systemic steroids and immunomodulators, along with oral topical application of triamcinolone acetonide resulted in complete remission in 2 months. This case report highlights the role of cytology in the diagnosis of vesiculobullous lesions and management protocol for BP patients presenting with simultaneous skin and oral lesions.

大疱性类天疱疮(BP)是一种常见的免疫介导的水疱性疾病,主要累及皮肤,偶尔也有口腔表现。口腔黏膜的疱疹性病变具有相似的临床特征,因此,临床诊断需要借助一项有价值的诊室检查--脱落细胞学检查。本病例的细胞学检查排除了丘疹性荨麻疹的可能性,因为涂片中没有Tzanck细胞。活组织检查和直接免疫荧光进一步确诊为天疱疮。患者接受了全身类固醇激素和免疫调节剂治疗,并口服曲安奈德外用药,两个月后病情完全缓解。本病例报告强调了细胞学在诊断膀胱疱疹病变中的作用,以及对同时出现皮肤和口腔病变的 BP 患者的治疗方案。
{"title":"Clinical management of bullous pemphigoid-The importance of cytology in diagnosis.","authors":"Preethi Ramesh, C V Divyambika, Aravind S Warrier, Leena Dennis Joseph","doi":"10.4103/jomfp.jomfp_544_23","DOIUrl":"10.4103/jomfp.jomfp_544_23","url":null,"abstract":"<p><p>Bullous pemphigoid (BP) is a common immune-mediated blistering disorder with predominant skin involvement and occasionally oral manifestations. Vesiculobullous lesions of the oral mucosa present with similar clinical features, and hence arriving at a clinical diagnosis is aided by a valuable chairside investigation, exfoliative cytology. Cytology done in the present case ruled out pemphigus because of the absence of Tzanck cells in the smear. Biopsy and direct immunofluorescence further confirmed the diagnosis of BP. Treatment initiated with systemic steroids and immunomodulators, along with oral topical application of triamcinolone acetonide resulted in complete remission in 2 months. This case report highlights the role of cytology in the diagnosis of vesiculobullous lesions and management protocol for BP patients presenting with simultaneous skin and oral lesions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"328-331"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative cytopathological investigatory aids in the diagnosis of salivary gland lesions. 术前细胞病理学检查有助于诊断唾液腺病变。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_132_24
S Vidyalakshmi, K Shanmugasamy

Salivary gland lesions are a group of heterogeneous lesions inclusive of non-neoplastic and neoplastic lesions. History, clinical examination and preoperative investigations attempt to minimise the challenges faced in diagnosing these diverse lesions. Preoperative investigations include imaging and cytopathology. The advent of onsite evaluation methods to ensure sample adequacy and newer reporting systems that assign risk of malignancy has improved the sensitivity and specificity of cytopathology. The scope of this review is limited to the preoperative cytopathological investigations and the diagnostic challenges met in reporting salivary gland tumours.

唾液腺病变是一组异质性病变,包括非肿瘤性和肿瘤性病变。病史、临床检查和术前检查可尽量减少诊断这些不同病变时所面临的挑战。术前检查包括影像学检查和细胞病理学检查。现场评估方法可确保样本的充分性,较新的报告系统可确定恶性风险,这些都提高了细胞病理学的敏感性和特异性。本综述的范围仅限于术前细胞病理学检查和报告唾液腺肿瘤时遇到的诊断难题。
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引用次数: 0
Role of C-reactive protein, IL-6, and D-dimers in prediction of severity of coronavirus disease 2019: A pilot study. C 反应蛋白、IL-6 和 D-二聚体在预测 2019 年冠状病毒疾病严重程度中的作用:一项试点研究。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_28_24
Pramod Jahagirdar, Kalpesh Vaishnav, Niharika Abhay Sarathy, Harneet Singh, Komal Kumia, Abhishek Banerjee

Background: The global outbreak of coronavirus disease 2019 (COVID-19) presents numerous obstacles for healthcare professionals. The present study aimed to evaluate and compare the role of serum biomarkers like- C-reactive protein (CRP), interleukin-6 (IL-6), and D-dimers in the severity of COVID-19 infection.

Methodology: A cross-sectional, observational retrospective pilot study was conducted in Udaipur, Rajasthan, wherein data was collected from 250 subjects, out of which, data of 100 subjects were included as per the inclusion criteria. The data was recorded retrospectively among the health professionals via Google Forms in Udaipur, Rajasthan.

Results: There were 1 (1%), 3 (3%), 31 (31%) and 65 (65%) participants with minor elevation (0.3-1.0), moderate elevation (1-10), marked elevation (10-50) and severe elevation (>50) of CRP respectively. The difference between the groups was statistically highly significant with a significantly higher number of study participants with a severe elevation of CRP levels (χ2 = 107.84, P < 0.001). The results showed that there was a significant difference between the groups with IL6 in 0-7 range while 96 (96%) study participants had >7 IL6, and the difference was statistically highly significant (2 = 84.640, P 0.001).

Conclusion: In conclusion, the existing body of research indicates a discernible correlation between COVID-19 infection and the fluctuation of biomarker levels. This supplement has the potential to be utilised in clinical practice as a means of informing treatment decisions and determining the necessity of admission to the intensive care unit (ICU).

背景:2019年冠状病毒病(COVID-19)的全球爆发给医护人员带来了许多障碍。本研究旨在评估和比较C反应蛋白(CRP)、白细胞介素-6(IL-6)和D-二聚体等血清生物标志物在COVID-19感染严重程度中的作用:在拉贾斯坦邦乌代布尔开展了一项横断面观察性回顾性试验研究,收集了 250 名受试者的数据,其中 100 名受试者的数据符合纳入标准。数据通过谷歌表格在拉贾斯坦邦乌代布尔的医疗专业人员中进行了回顾性记录:CRP轻度升高(0.3-1.0)、中度升高(1-10)、明显升高(10-50)和严重升高(>50)的受试者分别有 1 人(1%)、3 人(3%)、31 人(31%)和 65 人(65%)。组间差异具有高度统计学意义,CRP 水平严重升高的研究参与者人数明显较多(χ2 = 107.84,P < 0.001)。结果显示,IL6在0-7范围内的研究组之间存在显著差异,而96名(96%)研究参与者的IL6大于7,差异具有高度统计学意义(2 = 84.640,P 0.001):总之,现有研究表明,COVID-19 感染与生物标志物水平波动之间存在明显的相关性。临床实践中有可能利用这一补充信息,为治疗决策提供依据,并确定是否有必要入住重症监护室(ICU)。
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引用次数: 0
Unusual presentation of primary central xanthoma of the maxilla associated with impacted canine: An update on immunohistochemistry in the diagnosis. 上颌骨原发性中央黄瘤伴有犬齿撞击的不寻常表现:免疫组化诊断的最新进展。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_303_23
S Shivananda, Vidya G Doddawad, C S Vidya, S Sowmya

A xanthoma is an extremely rare condition that affects the soft tissues and bones and is characterized by a predominance of lipid-rich foamy histiocytes. The onset of xanthomas is frequently accompanied by primary or secondary hyperlipidemia. Primary bone xanthomas are very uncommon benign bone lesions that are not linked to hyperlipidemia. Histopathologically, they are distinguished by histiocytes, an abundance of foam cells or xanthoma cells that contain lipids, and a paucity of multinucleated giant cells. There have only been four reports of primary maxillary xanthoma in the medical literature. We present a rare primary intrabony xanthoma of the anterior maxilla in a 23-year-old normolipidemic female patient with solitary radiolucency. Using CD68, S-100, and CD1a immunohistochemical staining, it is possible to distinguish between macrophage/non-Langerhans histiocytes and Langerhans histiocytes. Therefore, a diagnosis of a central xanthoma of the jaws must be made.

黄疽瘤是一种极为罕见的疾病,会影响软组织和骨骼,其特征是富含脂质的泡沫组织细胞占主导地位。黄瘤的发病常伴有原发性或继发性高脂血症。原发性骨黄瘤是一种非常罕见的良性骨病变,与高脂血症无关。从组织病理学角度看,它们的特征是组织细胞、大量泡沫细胞或含脂质的黄瘤细胞,而多核巨细胞则很少。医学文献中仅有四篇关于原发性上颌骨黄瘤的报道。我们介绍了一名罕见的原发性上颌骨前部骨内黄瘤,患者是一名 23 岁的女性,血脂正常,伴有单发放射性黄斑。通过CD68、S-100和CD1a免疫组化染色,可以区分巨噬细胞/非朗格汉斯组织细胞和朗格汉斯组织细胞。因此,必须诊断为颌骨中央黄瘤。
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引用次数: 0
Low-grade dermatofibrosarcoma protuberance - A rare case report. 低级别皮纤维肉瘤突起--罕见病例报告。
Q3 Medicine Pub Date : 2024-04-01 Epub Date: 2024-07-11 DOI: 10.4103/jomfp.jomfp_135_23
T L Yogesh, Anjani Kumar Jha, Sindhumati Jayaraman, Vidhya Jayaraman

Dermatofibrosarcoma protuberans (DFSP) is a slow-growing, soft-tissue tumour of early or mid-adult life, affecting both the genders equally. The most common sites are soft tissue of the trunk (50 to 60%), followed by proximal extremities (20 to 30%) and the head and neck region (10 to 15%). Its metastatic potential is low though the local recurrence rate is high. Here, we report a case of a female patient with a large soft tissue growth located at the right cheek, chin and neck region. Local excision was done under the impression of a benign tumour such as lipoma or sebaceous cyst. Histological evaluation showed bland spindle cells arranged in a storiform pattern questioning the provisional diagnosis of the lesion. Further evaluation with the immunohistochemistry (IHC) panel confirmed the diagnosis of DFSP. Since it is a rare tumour of the head and neck region with non-alarming initial presentation and the potential for erroneous diagnosis as another lesion, we present a case of DFSP.

原发性皮肤纤维肉瘤(DFSP)是一种生长缓慢的软组织肿瘤,多发于成年早期或中期,男女均可患病。最常见的部位是躯干软组织(50% 至 60%),其次是四肢近端(20% 至 30%)和头颈部(10% 至 15%)。虽然局部复发率较高,但其转移潜力较低。在此,我们报告了一例女性患者的病例,她的右脸颊、下巴和颈部有一大片软组织增生。患者被误认为是脂肪瘤或皮脂腺囊肿等良性肿瘤,因此进行了局部切除手术。组织学评估显示,平滑的纺锤形细胞呈星状排列,这对病变的初步诊断提出了质疑。免疫组化(IHC)小组的进一步评估证实了 DFSP 的诊断。由于这是一种罕见的头颈部肿瘤,初始表现并不可怕,而且有可能被误诊为其他病变,因此我们介绍了一例 DFSP 病例。
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引用次数: 0
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Journal of Oral and Maxillofacial Pathology
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