Pub Date : 2016-10-01DOI: 10.1177/0270467617707079
J. Powell
Skuce et al., responding to Powell, title their article, “Does It Matter if the Consensus on Anthropogenic Global Warming Is 97% or 99.99%?” I argue that the extent of the consensus does matter, most of all because scholars have shown that the stronger the public believe the consensus to be, the more they support the action on global warming that human society so desperately needs. Moreover, anyone who knows that scientists once thought that the continents are fixed in place, or that the craters of the Moon are volcanic, or that the Earth cannot be more than 100 million years old, understands that a small minority has sometimes turned out to be right. But it is hard to think of a case in the modern era in which scientists have been virtually unanimous and wrong. Moreover, as I show, the consensus among publishing scientists is demonstrably not 97%. Instead, five surveys of the peer-reviewed literature from 1991 to 2015 combine to 54,195 articles with an average consensus of 99.94%.
{"title":"The Consensus on Anthropogenic Global Warming Matters","authors":"J. Powell","doi":"10.1177/0270467617707079","DOIUrl":"https://doi.org/10.1177/0270467617707079","url":null,"abstract":"Skuce et al., responding to Powell, title their article, “Does It Matter if the Consensus on Anthropogenic Global Warming Is 97% or 99.99%?” I argue that the extent of the consensus does matter, most of all because scholars have shown that the stronger the public believe the consensus to be, the more they support the action on global warming that human society so desperately needs. Moreover, anyone who knows that scientists once thought that the continents are fixed in place, or that the craters of the Moon are volcanic, or that the Earth cannot be more than 100 million years old, understands that a small minority has sometimes turned out to be right. But it is hard to think of a case in the modern era in which scientists have been virtually unanimous and wrong. Moreover, as I show, the consensus among publishing scientists is demonstrably not 97%. Instead, five surveys of the peer-reviewed literature from 1991 to 2015 combine to 54,195 articles with an average consensus of 99.94%.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"11 1","pages":"157 - 163"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467617707079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65144227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-01DOI: 10.1177/0270467616687217
John Mihelich, Dilshani Sarathchandra, Leontina M. Hormel, Debbie A. Storrs, M. Wiest
Over the past few decades, public anxiety about how people interact with science has spawned cycles of discourse across a wide range of media, public and private initiatives, and substantial research endeavors. National and international STEM (science, technology, engineering, and math) education initiatives and research have addressed how students interact with science and pursue careers in STEM fields. Researchers concerned with adult interaction with science have focused on factors that influence how citizens gather and interpret scientific knowledge and form positions on scientific issues, applications, and/or policy in a politicized democratic milieu. Building from research on how the public interacts with science in and outside of formal education, this study focuses on attitudes toward science among students in 4th, 7th, and 10th grades and their parents. Little research to date has paired the STEM experiences of adults with their children. We find that the extent to which parents are positively oriented toward science significantly shapes their children’s attitudes toward science. Furthermore, between 7th and 10th grades, students with parents holding positive orientations toward science are more likely to sustain positive attitudes toward science. Since the foundation for most adults’ interactions with science develops in the K-12 environment, we demonstrate that the foundation, as expressed in adulthood, may directly affect the ways the next generation of students interacts with science. We offer insights into the importance of developing student learning into the social scientific research on public understanding of science and how important scientific issues of today interplay with society.
{"title":"Public Understanding of Science and K-12 STEM Education Outcomes: Effects of Idaho Parents’ Orientation Toward Science on Students’ Attitudes Toward Science","authors":"John Mihelich, Dilshani Sarathchandra, Leontina M. Hormel, Debbie A. Storrs, M. Wiest","doi":"10.1177/0270467616687217","DOIUrl":"https://doi.org/10.1177/0270467616687217","url":null,"abstract":"Over the past few decades, public anxiety about how people interact with science has spawned cycles of discourse across a wide range of media, public and private initiatives, and substantial research endeavors. National and international STEM (science, technology, engineering, and math) education initiatives and research have addressed how students interact with science and pursue careers in STEM fields. Researchers concerned with adult interaction with science have focused on factors that influence how citizens gather and interpret scientific knowledge and form positions on scientific issues, applications, and/or policy in a politicized democratic milieu. Building from research on how the public interacts with science in and outside of formal education, this study focuses on attitudes toward science among students in 4th, 7th, and 10th grades and their parents. Little research to date has paired the STEM experiences of adults with their children. We find that the extent to which parents are positively oriented toward science significantly shapes their children’s attitudes toward science. Furthermore, between 7th and 10th grades, students with parents holding positive orientations toward science are more likely to sustain positive attitudes toward science. Since the foundation for most adults’ interactions with science develops in the K-12 environment, we demonstrate that the foundation, as expressed in adulthood, may directly affect the ways the next generation of students interacts with science. We offer insights into the importance of developing student learning into the social scientific research on public understanding of science and how important scientific issues of today interplay with society.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"164 - 178"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616687217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65144112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-01DOI: 10.1177/0270467617707432
S. Losh
{"title":"Why It Matters: U.S. Adult Perceptions of Environmental Scientist Agreement on Global Warming","authors":"S. Losh","doi":"10.1177/0270467617707432","DOIUrl":"https://doi.org/10.1177/0270467617707432","url":null,"abstract":"","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"147 - 149"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467617707432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65144238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.1177/0270467616668760
Nadine Levin, S. Leonelli, Dagmara Weckowska, D. Castle, J. Dupré
This article documents how biomedical researchers in the United Kingdom understand and enact the idea of “openness.” This is of particular interest to researchers and science policy worldwide in view of the recent adoption of pioneering policies on Open Science and Open Access by the U.K. government—policies whose impact on and implications for research practice are in need of urgent evaluation, so as to decide on their eventual implementation elsewhere. This study is based on 22 in-depth interviews with U.K. researchers in systems biology, synthetic biology, and bioinformatics, which were conducted between September 2013 and February 2014. Through an analysis of the interview transcripts, we identify seven core themes that characterize researchers’ understanding of openness in science and nine factors that shape the practice of openness in research. Our findings highlight the implications that Open Science policies can have for research processes and outcomes and provide recommendations for enhancing their content, effectiveness, and implementation.
{"title":"How Do Scientists Define Openness? Exploring the Relationship Between Open Science Policies and Research Practice","authors":"Nadine Levin, S. Leonelli, Dagmara Weckowska, D. Castle, J. Dupré","doi":"10.1177/0270467616668760","DOIUrl":"https://doi.org/10.1177/0270467616668760","url":null,"abstract":"This article documents how biomedical researchers in the United Kingdom understand and enact the idea of “openness.” This is of particular interest to researchers and science policy worldwide in view of the recent adoption of pioneering policies on Open Science and Open Access by the U.K. government—policies whose impact on and implications for research practice are in need of urgent evaluation, so as to decide on their eventual implementation elsewhere. This study is based on 22 in-depth interviews with U.K. researchers in systems biology, synthetic biology, and bioinformatics, which were conducted between September 2013 and February 2014. Through an analysis of the interview transcripts, we identify seven core themes that characterize researchers’ understanding of openness in science and nine factors that shape the practice of openness in research. Our findings highlight the implications that Open Science policies can have for research processes and outcomes and provide recommendations for enhancing their content, effectiveness, and implementation.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"128 - 141"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616668760","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65144100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.1177/0270467616658745
A. Koblitz
Images of Middle Eastern women in the Western media tend toward the exotic, erotic, or abject. The women are often styled as the victims of patriarchal institutions and depicted as in need of being saved by their supposedly more enlightened Western sisters. These stereotypes carry over into Western media assumptions about the participation of Arab women in science and technology as well; few people are aware of the existence of professional women in STEM (science, technology, engineering, and mathematics) fields in the Middle East. This article discusses the experiences of expatriate Arab women in high-tech start-ups and other scientific enterprises in the United Arab Emirates and other countries of the Middle East. Among the issues addressed are experiences in the field and on temporary job locations, citizenship quandaries, family and community responsibilities, private versus governmental and semigovernmental employers, apparel/veiling considerations, and gender and racial prejudice. The essay is based on conversations with young women from Belorussia, Egypt, Jordan, Kuwait, Lebanon, and Palestine who work primarily as engineers and computer scientists.
{"title":"Life in the Fast Lane","authors":"A. Koblitz","doi":"10.1177/0270467616658745","DOIUrl":"https://doi.org/10.1177/0270467616658745","url":null,"abstract":"Images of Middle Eastern women in the Western media tend toward the exotic, erotic, or abject. The women are often styled as the victims of patriarchal institutions and depicted as in need of being saved by their supposedly more enlightened Western sisters. These stereotypes carry over into Western media assumptions about the participation of Arab women in science and technology as well; few people are aware of the existence of professional women in STEM (science, technology, engineering, and mathematics) fields in the Middle East. This article discusses the experiences of expatriate Arab women in high-tech start-ups and other scientific enterprises in the United Arab Emirates and other countries of the Middle East. Among the issues addressed are experiences in the field and on temporary job locations, citizenship quandaries, family and community responsibilities, private versus governmental and semigovernmental employers, apparel/veiling considerations, and gender and racial prejudice. The essay is based on conversations with young women from Belorussia, Egypt, Jordan, Kuwait, Lebanon, and Palestine who work primarily as engineers and computer scientists.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"107 - 117"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616658745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65143990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.1177/0270467616668075
M. Reza
Southeast Asian landscapes have been shifting from natural landscapes to the modified landscapes at a rate faster than ever. Ecological integrity is under tremendous pressure due to the anthropogenic developmental activities. Little attention, however, has been paid to identify the major underlying causes of this rapid landscape transformation. This article discusses these issues from the point of view of a landscape ecologist. Landsat TM 30 m satellite images of 1988, 1996, and Landsat ETM+ 30 m image of 2005 were classified using ERDAS Imagine 9.2. Vector-based Landscape Analysis Tools Extension software was used in analyzing landscape patterns. Landscape size and shape metrics have revealed that the main transformation occurred in the first period (between the years 1988 and 1996) which was due to the rapid extension of the commercial agriculture. However, in the second period (between the year 1996 and 2005), the main driver of rapid landscape transformation occurred due to the expansion of urban areas, transportation networks, housing, and township. The pace of developmental activities breaks all previous records at a faster rate in the second period as compared with the first. These findings will provide necessary information about the driving forces which have a potential use for sustainable management decision processes. Additionally, results and data on landscape patterns may help scientists, academics, and researchers in further study. They can also be of potential use for the sustainable management of natural resources, urban planning, and livable green cities.
{"title":"Southeast Asian Landscapes Are Facing Rapid Transition","authors":"M. Reza","doi":"10.1177/0270467616668075","DOIUrl":"https://doi.org/10.1177/0270467616668075","url":null,"abstract":"Southeast Asian landscapes have been shifting from natural landscapes to the modified landscapes at a rate faster than ever. Ecological integrity is under tremendous pressure due to the anthropogenic developmental activities. Little attention, however, has been paid to identify the major underlying causes of this rapid landscape transformation. This article discusses these issues from the point of view of a landscape ecologist. Landsat TM 30 m satellite images of 1988, 1996, and Landsat ETM+ 30 m image of 2005 were classified using ERDAS Imagine 9.2. Vector-based Landscape Analysis Tools Extension software was used in analyzing landscape patterns. Landscape size and shape metrics have revealed that the main transformation occurred in the first period (between the years 1988 and 1996) which was due to the rapid extension of the commercial agriculture. However, in the second period (between the year 1996 and 2005), the main driver of rapid landscape transformation occurred due to the expansion of urban areas, transportation networks, housing, and township. The pace of developmental activities breaks all previous records at a faster rate in the second period as compared with the first. These findings will provide necessary information about the driving forces which have a potential use for sustainable management decision processes. Additionally, results and data on landscape patterns may help scientists, academics, and researchers in further study. They can also be of potential use for the sustainable management of natural resources, urban planning, and livable green cities.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"118 - 127"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616668075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65144050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.1177/0270467616655951
Bradley J. Bond
The present study, grounded in gender schema theory, employed a posttest experimental design to examine how television might influence girls’ perceptions of STEM (science, technology, engineering, and mathematics). Girls (6-9 years old) were either exposed to stereotypical or counter-stereotypical STEM female television characters. In a posttest following exposure, girls reported math and science self-efficacy, preference for STEM and stereotypical careers, and perceptions of scientists’ gender using the draw-a-scientist procedure. Girls in the stereotype condition reported more interest in stereotypical careers and were more likely to perceive scientists as males than girls in the counter-stereotype STEM condition or a no exposure control. Girls in the counter-stereotype STEM condition did not differ from the no exposure control in any of the dependent variables. Results suggest that onetime exposure to televised stereotypes may activate existing gender schema, but that onetime exposure to televised counter-stereotypes may not have the capacity to alter girls’ STEM schema.
{"title":"Fairy Godmothers > Robots","authors":"Bradley J. Bond","doi":"10.1177/0270467616655951","DOIUrl":"https://doi.org/10.1177/0270467616655951","url":null,"abstract":"The present study, grounded in gender schema theory, employed a posttest experimental design to examine how television might influence girls’ perceptions of STEM (science, technology, engineering, and mathematics). Girls (6-9 years old) were either exposed to stereotypical or counter-stereotypical STEM female television characters. In a posttest following exposure, girls reported math and science self-efficacy, preference for STEM and stereotypical careers, and perceptions of scientists’ gender using the draw-a-scientist procedure. Girls in the stereotype condition reported more interest in stereotypical careers and were more likely to perceive scientists as males than girls in the counter-stereotype STEM condition or a no exposure control. Girls in the counter-stereotype STEM condition did not differ from the no exposure control in any of the dependent variables. Results suggest that onetime exposure to televised stereotypes may activate existing gender schema, but that onetime exposure to televised counter-stereotypes may not have the capacity to alter girls’ STEM schema.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"57 1","pages":"91 - 97"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616655951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65143938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.1177/0270467616658744
Qihao Ji, Di Cui
Drawing on recent developments in media entertainment research, this study examined the relationship between social question and answer (Q&A) websites use and users’ perceived enjoyment with the goal of expanding the line of research on the enjoyment of new and interactive forms of media entertainment. Special attention was paid to meaningfulness, self-presentation, and social presence, which were introduced as mediators. An online survey of users of a social Q&A website was carried out (N = 150). Results indicated an indirect effect of social Q&A websites usage on enjoyment through users’ meaningfulness, self-presentation success, and social presence. Theoretical implications and further directions were discussed in detail.
{"title":"The Enjoyment of Social Q&A Websites Usage","authors":"Qihao Ji, Di Cui","doi":"10.1177/0270467616658744","DOIUrl":"https://doi.org/10.1177/0270467616658744","url":null,"abstract":"Drawing on recent developments in media entertainment research, this study examined the relationship between social question and answer (Q&A) websites use and users’ perceived enjoyment with the goal of expanding the line of research on the enjoyment of new and interactive forms of media entertainment. Special attention was paid to meaningfulness, self-presentation, and social presence, which were introduced as mediators. An online survey of users of a social Q&A website was carried out (N = 150). Results indicated an indirect effect of social Q&A websites usage on enjoyment through users’ meaningfulness, self-presentation success, and social presence. Theoretical implications and further directions were discussed in detail.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"106 - 98"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616658744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65143981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01Epub Date: 2015-12-29DOI: 10.3892/or.2015.4528
Dan-Dan Yuan, Zhong-Xiu Zhu, Xia Zhang, Jie Liu
According to the 2012 statistics of the International Agency for Research on Cancer (IARC), gastric cancer is the fifth most common malignancy, and the third leading cause of cancer-related deaths worldwide. Conventional chemotherapy and radiation have shown limited efficacy for advanced gastric cancer, showing an overall survival (OS) rate of ~10 months. Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2), is the first approved molecularly targeted agent for HER2-overexpressing gastric cancer, which was found to prolong the OS and the progression-free survival (PFS) of patients. However, HER2 overexpression is present only in a minority of patients with gastric cancer. Hence, other targeted agents are urgently needed. Ramucirumab, a novel human IgG1 monoclonal antibody that selectively targets the extracellular domain of VEGF receptor 2 (VEGFR2), is regarded as a new standard second-line treatment for patients with advanced gastric cancer. The combination of two or more targeted agents directed against two different molecular targets may improve the survival of patients with advanced gastric cancer. Although great efforts have been made, the effect of targeted therapy for gastric cancer is limited. One key reason is that participants in clinical trials for new targeted agents were not selected by detection of the targeted molecule. Here, we review clinical trials related to molecular targets such as anti-epidermal growth factor receptor signaling including anti-HER2 and anti-EGFR1, anti-VEGF signaling, anti-mammalian target of rapamycin (mTOR), tyrosine kinase inhibitors (TKIs) and anti-MET.
根据国际癌症研究机构（IARC）2012 年的统计数据，胃癌是全球第五大最常见的恶性肿瘤，也是导致癌症相关死亡的第三大原因。传统化疗和放疗对晚期胃癌的疗效有限，总生存期（OS）约为 10 个月。曲妥珠单抗是一种针对人表皮生长因子受体 2（HER2）的单克隆抗体，是首个获批用于治疗 HER2 表达胃癌的分子靶向药物，可延长患者的 OS 和无进展生存期（PFS）。然而，HER2 过表达只存在于少数胃癌患者中。因此，迫切需要其他靶向药物。Ramucirumab是一种新型人IgG1单克隆抗体，可选择性地靶向血管内皮生长因子受体2（VEGFR2）的胞外域，被视为晚期胃癌患者二线治疗的新标准。两种或两种以上针对两种不同分子靶点的靶向药物联合使用，可提高晚期胃癌患者的生存率。尽管已经做出了巨大努力，但胃癌靶向治疗的效果有限。其中一个重要原因是，新靶向药物临床试验的参与者并不是通过检测靶向分子来选择的。在此，我们回顾了与抗表皮生长因子受体信号转导（包括抗HER2和抗EGFR1）、抗血管内皮生长因子信号转导、抗哺乳动物雷帕霉素靶点（mTOR）、酪氨酸激酶抑制剂（TKIs）和抗MET等分子靶点相关的临床试验。
{"title":"Targeted therapy for gastric cancer: Current status and future directions (Review).","authors":"Dan-Dan Yuan, Zhong-Xiu Zhu, Xia Zhang, Jie Liu","doi":"10.3892/or.2015.4528","DOIUrl":"10.3892/or.2015.4528","url":null,"abstract":"<p><p>According to the 2012 statistics of the International Agency for Research on Cancer (IARC), gastric cancer is the fifth most common malignancy, and the third leading cause of cancer-related deaths worldwide. Conventional chemotherapy and radiation have shown limited efficacy for advanced gastric cancer, showing an overall survival (OS) rate of ~10 months. Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2), is the first approved molecularly targeted agent for HER2-overexpressing gastric cancer, which was found to prolong the OS and the progression-free survival (PFS) of patients. However, HER2 overexpression is present only in a minority of patients with gastric cancer. Hence, other targeted agents are urgently needed. Ramucirumab, a novel human IgG1 monoclonal antibody that selectively targets the extracellular domain of VEGF receptor 2 (VEGFR2), is regarded as a new standard second-line treatment for patients with advanced gastric cancer. The combination of two or more targeted agents directed against two different molecular targets may improve the survival of patients with advanced gastric cancer. Although great efforts have been made, the effect of targeted therapy for gastric cancer is limited. One key reason is that participants in clinical trials for new targeted agents were not selected by detection of the targeted molecule. Here, we review clinical trials related to molecular targets such as anti-epidermal growth factor receptor signaling including anti-HER2 and anti-EGFR1, anti-VEGF signaling, anti-mammalian target of rapamycin (mTOR), tyrosine kinase inhibitors (TKIs) and anti-MET.</p>","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"10 1","pages":"1245-54"},"PeriodicalIF":4.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3892/or.2015.4528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87233773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/0270467616636198
Brittany Anne Chozinski
Science fiction is often used as a tool with which to think about actual science. While often this is depicted in terms of imaginary future potential, science fiction has also shown itself to be a poignant critique of existing science and a means of exploring our collective anxieties regarding the continued logic of current scientific development. This article explores the science fiction of organ transplantation, as mapped against scientific and medicolegal developments in actual organ transplantation. Explored through the lens of Adorno’s work on cultural criticism, it is argued that science fiction serves as a tool with which we address (and critique) the ethical boundaries (and fears, often colonial in nature) of actual organ transplantation. Science fiction works such as Larry Niven’s Known Space Universe and Repo! The Genetic Opera are examined, demonstrating that in critiquing the science of organ transplantation, fictionists ultimately come to examine changing cultural understandings of selfhood and embodiment.
{"title":"Science Fiction as Critique of Science","authors":"Brittany Anne Chozinski","doi":"10.1177/0270467616636198","DOIUrl":"https://doi.org/10.1177/0270467616636198","url":null,"abstract":"Science fiction is often used as a tool with which to think about actual science. While often this is depicted in terms of imaginary future potential, science fiction has also shown itself to be a poignant critique of existing science and a means of exploring our collective anxieties regarding the continued logic of current scientific development. This article explores the science fiction of organ transplantation, as mapped against scientific and medicolegal developments in actual organ transplantation. Explored through the lens of Adorno’s work on cultural criticism, it is argued that science fiction serves as a tool with which we address (and critique) the ethical boundaries (and fears, often colonial in nature) of actual organ transplantation. Science fiction works such as Larry Niven’s Known Space Universe and Repo! The Genetic Opera are examined, demonstrating that in critiquing the science of organ transplantation, fictionists ultimately come to examine changing cultural understandings of selfhood and embodiment.","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"36 1","pages":"58 - 66"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0270467616636198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65143766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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