Pub Date : 2022-01-04DOI: 10.17352/2455-5282.000145
Altaf Raisa, A. Imtiaz, Siraj Rabiya, Iqbal Jawaid, Hassan Faiza
Facial artery a branch of external carotid artery rarely develops an aneurysm due to its superficial location and small size that mostly leads to complete dissection rather than laceration of the vessel. Pseudo-aneurysms develop in the superficial temporal arteries in this region. Rupture of this aneurysm can lead to extravasation of blood within the adjacent soft tissues resulting in hemorrhage in some cases. Only a few cases of facial artery aneurysms have been reported in publications. We are therefore discussing here a case of left facial artery pseudoaneurysm secondary to trauma and its radiological imaging findings on CT angiogram.
{"title":"Post traumatic facial artery pseudoaneurysm-A case report","authors":"Altaf Raisa, A. Imtiaz, Siraj Rabiya, Iqbal Jawaid, Hassan Faiza","doi":"10.17352/2455-5282.000145","DOIUrl":"https://doi.org/10.17352/2455-5282.000145","url":null,"abstract":"Facial artery a branch of external carotid artery rarely develops an aneurysm due to its superficial location and small size that mostly leads to complete dissection rather than laceration of the vessel. Pseudo-aneurysms develop in the superficial temporal arteries in this region. Rupture of this aneurysm can lead to extravasation of blood within the adjacent soft tissues resulting in hemorrhage in some cases. Only a few cases of facial artery aneurysms have been reported in publications. We are therefore discussing here a case of left facial artery pseudoaneurysm secondary to trauma and its radiological imaging findings on CT angiogram.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133147008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-27DOI: 10.17352/2455-5282.000143
Kingdom David Lekpa, Barinem Vidona Willy
Background: The understanding of Craniometry with its associated craniometric points and dimensions have found immense applicable relevance in anthropology and neuroscience, ranging from growth determination, estimation of cranial deformities, personal biological profile identification and facial reconstructive surgeries, analysis of evolution of the human species in archeology as well as age variations. Objective: The aim of this study was to evaluate the craniometric dimensions among adults’ subjects in Eastern Nigerian State. Methods: Research data was collected from Computed Tomography scans in the Radiological Department of Federal Medical Centre, Umuahia, Nigeria with strict adherence to inclusive and exclusive factors. A total number of 150 human CT scans were used in the findings. Craniometric parameters were calculated - derived from the two and three coordinate points for linear and angular measurements respectively. Results: Results revealed that age group 36-45 had the lowest cranial parameters and age group 56-65 had the highest cranial parameters. Conclusion: It was concluded that cranial parameters does not increase as age increases throughout life. The study findings will be useful to the anatomists, anthropologists and neuroscientists.
{"title":"Anatomical evaluation of the craniometric points and dimensions among adult’s populations of the South-Eastern Nigerians and its implication for intracranial surgical procedures","authors":"Kingdom David Lekpa, Barinem Vidona Willy","doi":"10.17352/2455-5282.000143","DOIUrl":"https://doi.org/10.17352/2455-5282.000143","url":null,"abstract":"Background: The understanding of Craniometry with its associated craniometric points and dimensions have found immense applicable relevance in anthropology and neuroscience, ranging from growth determination, estimation of cranial deformities, personal biological profile identification and facial reconstructive surgeries, analysis of evolution of the human species in archeology as well as age variations. Objective: The aim of this study was to evaluate the craniometric dimensions among adults’ subjects in Eastern Nigerian State. Methods: Research data was collected from Computed Tomography scans in the Radiological Department of Federal Medical Centre, Umuahia, Nigeria with strict adherence to inclusive and exclusive factors. A total number of 150 human CT scans were used in the findings. Craniometric parameters were calculated - derived from the two and three coordinate points for linear and angular measurements respectively. Results: Results revealed that age group 36-45 had the lowest cranial parameters and age group 56-65 had the highest cranial parameters. Conclusion: It was concluded that cranial parameters does not increase as age increases throughout life. The study findings will be useful to the anatomists, anthropologists and neuroscientists.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123049323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-18DOI: 10.17352/2455-5282.000142
Hopper Wade, Veria Spiro, Glosser Logan, Garg Anu, Awad Mohammed T, Smith Justin, Din Shahab Ud
Xanthomas are benign cutaneous manifestations of extracellular lipid accumulation. Eruptive xanthoma is characterized by the acute, widespread presentation of a papular rash and usually involves the back, buttocks, and extremities. Eruptive xanthoma is associated with hyperlipidemia, hypertriglyceridemia, and an increased long-term risk of atherosclerotic cardiovascular disease. We present a case of eruptive xanthoma accompanied by severe hypertriglyceridemia (10,164 mg/dL) in which the course of the disease was reversed following implementation of lipid-lowering pharmacotherapy.
{"title":"Eruptive xanthomas secondary to severe hypertriglyceridemia","authors":"Hopper Wade, Veria Spiro, Glosser Logan, Garg Anu, Awad Mohammed T, Smith Justin, Din Shahab Ud","doi":"10.17352/2455-5282.000142","DOIUrl":"https://doi.org/10.17352/2455-5282.000142","url":null,"abstract":"Xanthomas are benign cutaneous manifestations of extracellular lipid accumulation. Eruptive xanthoma is characterized by the acute, widespread presentation of a papular rash and usually involves the back, buttocks, and extremities. Eruptive xanthoma is associated with hyperlipidemia, hypertriglyceridemia, and an increased long-term risk of atherosclerotic cardiovascular disease. We present a case of eruptive xanthoma accompanied by severe hypertriglyceridemia (10,164 mg/dL) in which the course of the disease was reversed following implementation of lipid-lowering pharmacotherapy.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124219980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-07DOI: 10.17352/2455-5282.000141
Solanki Prithviraj Kishoresingh, Bhide Vijayshri, Gadage Vijaya, K. Vinay, P. Anil
Mastocytosis is a disorder of clonal proliferation of the mast cells, which can be cutaneous or systemic. Abnormal mast cell infiltration comprising multifocal compact clusters or cohesive aggregates can affect one or more organ systems. Cutaneous mastocytosis is a relatively uncommon condition in the pediatric population. We report a case of 9 month infant presented with multiple papular and vesicular skin rashes since 6 months of age. On clinical examination Darier’s sign was negative. The serum tryptase levels were within normal limits. Clinical differential diagnoses were benign cephalic histiocytosis vs cutaneous mastocytosis. Skin biopsy revealed a mononuclear cell infiltrate in the papillary dermis reaching up to the dermo-epidermal junction. Toluidine blue staining highlighted the metachromatic granules. CD117, CD30 IHC stains were positive which confirmed the diagnosis of cutaneous mastocytosis. This case is presented to highlight the histomorphology and the special stains in cases of mastocytosis.
{"title":"Cutaneous mastocytosis in an infant: Case report and clinicopathological correlation","authors":"Solanki Prithviraj Kishoresingh, Bhide Vijayshri, Gadage Vijaya, K. Vinay, P. Anil","doi":"10.17352/2455-5282.000141","DOIUrl":"https://doi.org/10.17352/2455-5282.000141","url":null,"abstract":"Mastocytosis is a disorder of clonal proliferation of the mast cells, which can be cutaneous or systemic. Abnormal mast cell infiltration comprising multifocal compact clusters or cohesive aggregates can affect one or more organ systems. Cutaneous mastocytosis is a relatively uncommon condition in the pediatric population. We report a case of 9 month infant presented with multiple papular and vesicular skin rashes since 6 months of age. On clinical examination Darier’s sign was negative. The serum tryptase levels were within normal limits. Clinical differential diagnoses were benign cephalic histiocytosis vs cutaneous mastocytosis. Skin biopsy revealed a mononuclear cell infiltrate in the papillary dermis reaching up to the dermo-epidermal junction. Toluidine blue staining highlighted the metachromatic granules. CD117, CD30 IHC stains were positive which confirmed the diagnosis of cutaneous mastocytosis. This case is presented to highlight the histomorphology and the special stains in cases of mastocytosis.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131549368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-08DOI: 10.17352/2455-5282.000138
Gumasana Harshil, Patel Mansukh V
Background: Miliary Tuberculosis (MTB) is a potentially lethal disease if not diagnosed and treated early. Miliary tuberculosis infection in childhood remains a signifi cant health problem in developing countries. Clinical manifestations are non-specifi c and therefore the condition may bemuse even the most experienced clinicians. Infective Endocarditis (IE) remains a lethal valvular heart disease and can be fatal if not treated promptly. Coagulase-negative staphylococci and oral streptococci are common causative organisms. Both conditions can be fatal independently but can present in the same patient. Since fever is a common symptom in both, one infection may mask the other. Tuberculous Endocarditis (TBE) is another rare entity with few documented cases and often presents with a miliary tuberculosis picture, especially in endemic countries.
{"title":"Miliary Tuberculosis and Infective Endocarditis","authors":"Gumasana Harshil, Patel Mansukh V","doi":"10.17352/2455-5282.000138","DOIUrl":"https://doi.org/10.17352/2455-5282.000138","url":null,"abstract":"Background: Miliary Tuberculosis (MTB) is a potentially lethal disease if not diagnosed and treated early. Miliary tuberculosis infection in childhood remains a signifi cant health problem in developing countries. Clinical manifestations are non-specifi c and therefore the condition may bemuse even the most experienced clinicians. Infective Endocarditis (IE) remains a lethal valvular heart disease and can be fatal if not treated promptly. Coagulase-negative staphylococci and oral streptococci are common causative organisms. Both conditions can be fatal independently but can present in the same patient. Since fever is a common symptom in both, one infection may mask the other. Tuberculous Endocarditis (TBE) is another rare entity with few documented cases and often presents with a miliary tuberculosis picture, especially in endemic countries.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123720366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-24DOI: 10.17352/2455-5282.000137
Yutong Gao, Yuqing Chen
Objective: Systemic Juvenile Idiopathic Arthritis (SJIA) is a subtype of childhood rheumatoid arthritis, with the main clinical manifestations of high fever, recurrent rash, and arthritis. At present, it is generally believed that it is caused by the interaction of gene and environmental factors and has complex genetic characteristics. We report a case of a 1-year and 4-month SJIA patient with heterozygous mutation in PSTPIP1, and we studied the literature on this gene and related autoinfl ammatory diseases.
{"title":"Systemic juvenile idiopathic arthritis complicated with PSTPIP1 gene variant: A case report","authors":"Yutong Gao, Yuqing Chen","doi":"10.17352/2455-5282.000137","DOIUrl":"https://doi.org/10.17352/2455-5282.000137","url":null,"abstract":"Objective: Systemic Juvenile Idiopathic Arthritis (SJIA) is a subtype of childhood rheumatoid arthritis, with the main clinical manifestations of high fever, recurrent rash, and arthritis. At present, it is generally believed that it is caused by the interaction of gene and environmental factors and has complex genetic characteristics. We report a case of a 1-year and 4-month SJIA patient with heterozygous mutation in PSTPIP1, and we studied the literature on this gene and related autoinfl ammatory diseases.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131684859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.17352/2455-5282.000136
Razzaq Komal, A. Umair, Tahir Iqra, Rehman Touseef-ur, Liaqat Asima, Shafique Kaiynat, Almas Sabir Hafiz Muhammad
Background: This study investigated the effect of planter fascia stretch and heel pad with moist heat in the patients of planterfascitis among subjects aged 20-40. Planter fascia is a thickened fi brous sheet of connective tissue which begins from medial tubercle on undersurface of calcaneus and fans out joining to the metatarsophalangeal joints plates to form longitudinal foot arch. Manual active stretching or passive stretching of planter fascia and Achilles tendon are effective treatment option for patient with planter fasciitis. Aims and objectives: objectives of this study were to see the effect of planter fascia stretch and heel pad with moist heat in the patients of planterfascitis.
{"title":"A comparative study to analyze the effect of planter fascia stretch and heel pad with moist heat in the patients of planterfascitis","authors":"Razzaq Komal, A. Umair, Tahir Iqra, Rehman Touseef-ur, Liaqat Asima, Shafique Kaiynat, Almas Sabir Hafiz Muhammad","doi":"10.17352/2455-5282.000136","DOIUrl":"https://doi.org/10.17352/2455-5282.000136","url":null,"abstract":"Background: This study investigated the effect of planter fascia stretch and heel pad with moist heat in the patients of planterfascitis among subjects aged 20-40. Planter fascia is a thickened fi brous sheet of connective tissue which begins from medial tubercle on undersurface of calcaneus and fans out joining to the metatarsophalangeal joints plates to form longitudinal foot arch. Manual active stretching or passive stretching of planter fascia and Achilles tendon are effective treatment option for patient with planter fasciitis. Aims and objectives: objectives of this study were to see the effect of planter fascia stretch and heel pad with moist heat in the patients of planterfascitis.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131957013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.17352/2455-5282.000135
K. Ali
Acute Flaccid Paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness, in the respiratory muscles, swallowing and limbs; and death because of respiratory muscles failure. AFP surveillance is crucial, the clinicians are required to notify AFP cases among children below 15 years old to the epidemiology department with completion of AFP surveillance form. In this study, the researcher analyzed AFP surveillance investigation forms to determine the clinical picture, viral etiology and the incidence of AFP among children under 15 years. Material and method (Study design): The research study conducted through cross sectional study, based on AFP investigation forms in the epidemiology department. Results: The final diagnosis of the cases were as follow, 71.1% “27 cases” were GBS, 10.5 % were Encephalitis, 7.9% were Neuropathy, 2.6% “ one case only” for each of the following Aseptic meningitis, Transverse myelitis, Tuphus fever and Subspinal muscular atrophy. The incidence rate among children less than 15 years old which range from 0.58 / 100.000 in 2006 to 1.2 / 100.000 in 2012; Most of the cases 89.5 % had fully vaccinated and 10.5% had not fully vaccinated due to their ages less than one year, 65.8 “25 cases” had residual weakness, all of the cases classified as discarded according to the expert committee decision; no one case dead, all of the samples sent to the Tal-Hashomir laboratory in the occupied land in 1948 for viral isolation; most of the results 81.6% revealed that no virus isolated, 11.8% isolated ECHO virus, 2.6% isolated Coxsachie virus and 4 % isolated NPEV. Conclusion: No wild polio virus in Palestine which is polio free since 1984 and certified in 2006, our success being attributed to: start of 2 doses of IPV and 5 doses of OPV since 1978, high immunization coverage more than 95% at district level and effective AFP surveillance system in Palestine. The study recommended to encourage polio immunization and all clinicians are required to report all AFP cases and submitting at least two stool samples to the epidemiology department (at least 24 hours apart within 14 days of onset of paralysis).
{"title":"Acute Flaccid Paralysis surveillance in Gaza Strip, Palestine","authors":"K. Ali","doi":"10.17352/2455-5282.000135","DOIUrl":"https://doi.org/10.17352/2455-5282.000135","url":null,"abstract":"Acute Flaccid Paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness, in the respiratory muscles, swallowing and limbs; and death because of respiratory muscles failure. \u0000AFP surveillance is crucial, the clinicians are required to notify AFP cases among children below 15 years old to the epidemiology department with completion of AFP surveillance form. \u0000In this study, the researcher analyzed AFP surveillance investigation forms to determine the clinical picture, viral etiology and the incidence of AFP among children under 15 years. \u0000Material and method (Study design): The research study conducted through cross sectional study, based on AFP investigation forms in the epidemiology department. \u0000Results: The final diagnosis of the cases were as follow, 71.1% “27 cases” were GBS, 10.5 % were Encephalitis, 7.9% were Neuropathy, 2.6% “ one case only” for each of the following Aseptic meningitis, Transverse myelitis, Tuphus fever and Subspinal muscular atrophy. \u0000The incidence rate among children less than 15 years old which range from 0.58 / 100.000 in 2006 to 1.2 / 100.000 in 2012; Most of the cases 89.5 % had fully vaccinated and 10.5% had not fully vaccinated due to their ages less than one year, 65.8 “25 cases” had residual weakness, all of the cases classified as discarded according to the expert committee decision; no one case dead, all of the samples sent to the Tal-Hashomir laboratory in the occupied land in 1948 for viral isolation; most of the results 81.6% revealed that no virus isolated, 11.8% isolated ECHO virus, 2.6% isolated Coxsachie virus and 4 % isolated NPEV. \u0000Conclusion: No wild polio virus in Palestine which is polio free since 1984 and certified in 2006, our success being attributed to: start of 2 doses of IPV and 5 doses of OPV since 1978, high immunization coverage more than 95% at district level and effective AFP surveillance system in Palestine. The study recommended to encourage polio immunization and all clinicians are required to report all AFP cases and submitting at least two stool samples to the epidemiology department (at least 24 hours apart within 14 days of onset of paralysis).","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126033797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-28DOI: 10.17352/2455-5282.000133
Vanitha Palanisamy, Sia Kian Joo, C. A. Wee, M. Amin, S. Hashim, Ng Syiao Wei
Tracheo-Oesophageal Puncture (TEP) with voice prosthesis insertion is considered as a gold standard among various voice rehabilitation procedures in laryngectomized patients. It is easily reversible with a high success rate, and the speech, which closely resembles laryngeal speech, develops faster than esophageal speech. However the prosthesis has to be cleaned regularly to ensure proper function as well as longevity of the voice prosthesis valve system. There are not many incidents of the voice prosthesis cleaning brush reported, as the cleaning brush is made to be durable and able to withstand repetitive usage. Hereby we describe an unusual case of a laryngectomized patient who had aspirated a broken tip of a cleaning brush while cleaning his voice prosthesis. The delay in removal of the aspirated foreign body due to technical difficulty had led to lung collapse subjecting the patient to partial lobectomy. We would like to highlight several aspects in this case report, firstly patients should be counselled regarding the proper techniques to clean the voice prosthesis and they should be vigilant during the cleaning process to prevent aspiration in case of accidental broken of cleaning brush. Secondly the incident should be reported to the manufacturer so that the durability of the cleaning brush is reviewed and improvised. Lastly, prompt management of foreign body aspiration should be implied to prevent complications.
{"title":"An unusual case of foreign body aspiration","authors":"Vanitha Palanisamy, Sia Kian Joo, C. A. Wee, M. Amin, S. Hashim, Ng Syiao Wei","doi":"10.17352/2455-5282.000133","DOIUrl":"https://doi.org/10.17352/2455-5282.000133","url":null,"abstract":"Tracheo-Oesophageal Puncture (TEP) with voice prosthesis insertion is considered as a gold standard among various voice rehabilitation procedures in laryngectomized patients. It is easily reversible with a high success rate, and the speech, which closely resembles laryngeal speech, develops faster than esophageal speech. However the prosthesis has to be cleaned regularly to ensure proper function as well as longevity of the voice prosthesis valve system. There are not many incidents of the voice prosthesis cleaning brush reported, as the cleaning brush is made to be durable and able to withstand repetitive usage. Hereby we describe an unusual case of a laryngectomized patient who had aspirated a broken tip of a cleaning brush while cleaning his voice prosthesis. The delay in removal of the aspirated foreign body due to technical difficulty had led to lung collapse subjecting the patient to partial lobectomy. We would like to highlight several aspects in this case report, firstly patients should be counselled regarding the proper techniques to clean the voice prosthesis and they should be vigilant during the cleaning process to prevent aspiration in case of accidental broken of cleaning brush. Secondly the incident should be reported to the manufacturer so that the durability of the cleaning brush is reviewed and improvised. Lastly, prompt management of foreign body aspiration should be implied to prevent complications.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114622243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progressionfree survival of only 3 months [2,3]. Even though Merkel cell carcinoma frequently shows lymphatic metastases, it almost never shows cerebral involvement [1]. To our knowledge there are only twelve reported cases of cerebral metastases. Furthermore this is the fi rst reported case of complete response in a patient with advanced Merkel cell carcinoma Stage IV with brain metastases under combined treatment with pembrolizumab and radiotherapy.
{"title":"Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report","authors":"Koechel Ansgar, Hilke Franz-Joachim, Klumpp Bernhard, Schroeder Christopher, Eigentler Thomas, Lomberg Diana, Garbe Claus, Leiter Ulrike","doi":"10.17352/2455-5282.000129","DOIUrl":"https://doi.org/10.17352/2455-5282.000129","url":null,"abstract":"Merkel cell carcinoma is a rare, but highly malignant and fast growing skin-cancer with high recurrence-rates, deriving from endothelial and neuroendocrine tissues. For advanced Merkel cell carcinoma prognosis is poor [1] and even under cytotoxic chemotherapy there is only a median progressionfree survival of only 3 months [2,3]. Even though Merkel cell carcinoma frequently shows lymphatic metastases, it almost never shows cerebral involvement [1]. To our knowledge there are only twelve reported cases of cerebral metastases. Furthermore this is the fi rst reported case of complete response in a patient with advanced Merkel cell carcinoma Stage IV with brain metastases under combined treatment with pembrolizumab and radiotherapy.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130726720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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