Pub Date : 2022-07-22DOI: 10.17352/2455-5282.000155
Ode Abu, ON Orobator, I. Momodu
The aim of the present study was to evaluate the hepatoprotective effect of total saponins and tannins of Dialium guineense stem bark in Wistar rats exposed to carbon tetrachloride (CCl4). Adult male Wistar rats (n = 25) weighing 160 – 180 g (mean weight = 170 ± 10 g) were randomly assigned to five groups (5 rats per group): normal control, CCl4 control, silymarin, total saponins, and total tannins groups. With the exception of normal control, the rats were exposed to CCl4 (a single oral dose of 1.0 mL/kg body weight, bwt). Rats in the silymarin group were administered 100 mg/kg bwt silymarin (standard hepatoprotective drug), while those in the two treatment groups received 150 mg/kg bwt of total saponins or tannins orally. Treatment lasted 28 days. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Alkaline Phosphatase (ALP), as well as levels of Total Protein (TP), bilirubin, and albumin, were measured in plasma. The results showed that there were no significant differences in the concentrations of TP among the groups (p > 0.05). The activities of the liver enzymes, as well as levels of bilirubin and albumin, were significantly higher in the CCl4 control group than in the normal control group, but they were reduced by extract treatment (p < 0.05). These results indicate that CCl4 negatively impacted the integrity of the liver cells, and total saponins and tannins of D. guineense stem bark conferred some level of protection on the organ.
{"title":"Evaluation of the effect of total saponins and tannins isolated from Dialium guineense stem bark on CCl4 - Induced hepatotoxicity in wistar rats","authors":"Ode Abu, ON Orobator, I. Momodu","doi":"10.17352/2455-5282.000155","DOIUrl":"https://doi.org/10.17352/2455-5282.000155","url":null,"abstract":"The aim of the present study was to evaluate the hepatoprotective effect of total saponins and tannins of Dialium guineense stem bark in Wistar rats exposed to carbon tetrachloride (CCl4). Adult male Wistar rats (n = 25) weighing 160 – 180 g (mean weight = 170 ± 10 g) were randomly assigned to five groups (5 rats per group): normal control, CCl4 control, silymarin, total saponins, and total tannins groups. With the exception of normal control, the rats were exposed to CCl4 (a single oral dose of 1.0 mL/kg body weight, bwt). Rats in the silymarin group were administered 100 mg/kg bwt silymarin (standard hepatoprotective drug), while those in the two treatment groups received 150 mg/kg bwt of total saponins or tannins orally. Treatment lasted 28 days. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Alkaline Phosphatase (ALP), as well as levels of Total Protein (TP), bilirubin, and albumin, were measured in plasma. The results showed that there were no significant differences in the concentrations of TP among the groups (p > 0.05). The activities of the liver enzymes, as well as levels of bilirubin and albumin, were significantly higher in the CCl4 control group than in the normal control group, but they were reduced by extract treatment (p < 0.05). These results indicate that CCl4 negatively impacted the integrity of the liver cells, and total saponins and tannins of D. guineense stem bark conferred some level of protection on the organ.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126529337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-30DOI: 10.17352/2455-5282.000154
Haddad Christian, Saliba Rindala, Ibrahim Racha, Choucair Jacques
Listeria monocytogenes infection in humans is mostly asymptomatic in immunocompetent patients. It rarely can cause self-limiting febrile gastroenteritis, bacteremia, meningoencephalitis, and maternal-neonatal infections. The latter three manifestations are the most common, especially among immunocompromised patients. We present two cases of Listeria monocytogenes bacteremia in cancer patients, a 79-year-old man and a 70-year-old woman in whom the source of bacteremia was identified to be the implantable venous access port (TIVAP). In both cases, the TIVAP has been removed after “positive control cultures the following readmission to the hospital despite targeted therapy with ampicillin and gentamicin”. Removal of TIVAP was warranted to control the infection.
{"title":"Totally implantable venous access port infection with Listeria monocytogenes: 2 case reports at a tertiary center and literature review","authors":"Haddad Christian, Saliba Rindala, Ibrahim Racha, Choucair Jacques","doi":"10.17352/2455-5282.000154","DOIUrl":"https://doi.org/10.17352/2455-5282.000154","url":null,"abstract":"Listeria monocytogenes infection in humans is mostly asymptomatic in immunocompetent patients. It rarely can cause self-limiting febrile gastroenteritis, bacteremia, meningoencephalitis, and maternal-neonatal infections. The latter three manifestations are the most common, especially among immunocompromised patients. We present two cases of Listeria monocytogenes bacteremia in cancer patients, a 79-year-old man and a 70-year-old woman in whom the source of bacteremia was identified to be the implantable venous access port (TIVAP). In both cases, the TIVAP has been removed after “positive control cultures the following readmission to the hospital despite targeted therapy with ampicillin and gentamicin”. Removal of TIVAP was warranted to control the infection.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114562705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-27DOI: 10.17352/2455-5282.000153
Pinto Filho João Ernesto Aldred, Ejje Kailly Pedro Henrique, Louback Filho Ruston da Matta, Renteria Juan Miguel, Claudio Antonio, Cunha Ahouagi
Actinic cystitis hematuria is a frequent complication after pelvic radiotherapy, present in approximately 5% of patients exposed to this therapy. The management of these cases seems to be a challenge for today’s urologists. In this article, we present the case of a 73- year-old man diagnosed with actinic cystitis after pelvic radiotherapy and admitted to our service with a clinical picture of refractory macroscopic hematuria. During admission, the patient underwent multiple procedures and blood transfusions, without success in controlling hematuria. After a review of the literature, we chose to use Potassium Alum in the patient’s treatment. Under general anesthesia, we performed a cystoscopy with the evacuation of clots and subsequently infused a 1% solution of potassium alum into the bladder at a rate of 200 ml/h for 25 hours. Less than 24 hours after Alum infusion, there were no more clinical signs of hematuria, which remained until hospital discharge. After 6 months of treatment, the patient did not present another episode of hematuria.
{"title":"Refractory hematuria post actinic cystitis. Role of potassium alumen as treatment - Case Report","authors":"Pinto Filho João Ernesto Aldred, Ejje Kailly Pedro Henrique, Louback Filho Ruston da Matta, Renteria Juan Miguel, Claudio Antonio, Cunha Ahouagi","doi":"10.17352/2455-5282.000153","DOIUrl":"https://doi.org/10.17352/2455-5282.000153","url":null,"abstract":"Actinic cystitis hematuria is a frequent complication after pelvic radiotherapy, present in approximately 5% of patients exposed to this therapy. The management of these cases seems to be a challenge for today’s urologists. In this article, we present the case of a 73- year-old man diagnosed with actinic cystitis after pelvic radiotherapy and admitted to our service with a clinical picture of refractory macroscopic hematuria. During admission, the patient underwent multiple procedures and blood transfusions, without success in controlling hematuria. After a review of the literature, we chose to use Potassium Alum in the patient’s treatment. Under general anesthesia, we performed a cystoscopy with the evacuation of clots and subsequently infused a 1% solution of potassium alum into the bladder at a rate of 200 ml/h for 25 hours. Less than 24 hours after Alum infusion, there were no more clinical signs of hematuria, which remained until hospital discharge. After 6 months of treatment, the patient did not present another episode of hematuria.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116764119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-07DOI: 10.17352/2455-5282.000152
Haddad Christian, Awali Mohamad, I. Salim, Gudero Getachew, C. Jacques
Pneumomediastinum is a rare complication described following dental extraction, especially of the third molar. 212 case reports were described in the English literature since 1960. We describe a case report of a 19-year-old girl who presented to the emergency department with subcutaneous emphysema. Investigations showed the presence of pneumomediastinum. The patient was admitted for surveillance with no antibiotic therapy given due to the improvement seen the following day.
{"title":"Pneumomediastinum following dental extraction – a case report in a tertiary hospital","authors":"Haddad Christian, Awali Mohamad, I. Salim, Gudero Getachew, C. Jacques","doi":"10.17352/2455-5282.000152","DOIUrl":"https://doi.org/10.17352/2455-5282.000152","url":null,"abstract":"Pneumomediastinum is a rare complication described following dental extraction, especially of the third molar. 212 case reports were described in the English literature since 1960. We describe a case report of a 19-year-old girl who presented to the emergency department with subcutaneous emphysema. Investigations showed the presence of pneumomediastinum. The patient was admitted for surveillance with no antibiotic therapy given due to the improvement seen the following day.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127024737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.17352/2455-5282.000151
Tanni Afia Zainab, Uddin Md Farid, Arafat Shohael Mahmud, Selim Shahjada, Mustari Marufa, Chowdhury MSI Tipu
The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.
{"title":"Glimepiride induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A case report","authors":"Tanni Afia Zainab, Uddin Md Farid, Arafat Shohael Mahmud, Selim Shahjada, Mustari Marufa, Chowdhury MSI Tipu","doi":"10.17352/2455-5282.000151","DOIUrl":"https://doi.org/10.17352/2455-5282.000151","url":null,"abstract":"The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"47 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114015441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.17352/2455-5282.000150
Baiya Mahjouba, Yahyaoui Hicham, Mhirig Ibtissam, Khannouri Imane El, Ameur Mustapha Ait, C. Mohamed
A 65-year-old man was diagnosed with multiple myeloma (IgG-Lambda) and was treated with high-dose dexamethasone as induction therapy followed by thalidomide-based regimens. About 18 months after the initial diagnosis, the patient presented a first relapse which was treated with the LCD protocol (Lenalidomide, Cyclophosphamide, Dexamethasone).
{"title":"Cloverleaf plasma cell nuclei in multiple myeloma","authors":"Baiya Mahjouba, Yahyaoui Hicham, Mhirig Ibtissam, Khannouri Imane El, Ameur Mustapha Ait, C. Mohamed","doi":"10.17352/2455-5282.000150","DOIUrl":"https://doi.org/10.17352/2455-5282.000150","url":null,"abstract":"A 65-year-old man was diagnosed with multiple myeloma (IgG-Lambda) and was treated with high-dose dexamethasone as induction therapy followed by thalidomide-based regimens. About 18 months after the initial diagnosis, the patient presented a first relapse which was treated with the LCD protocol (Lenalidomide, Cyclophosphamide, Dexamethasone).","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128173682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-09DOI: 10.17352/2455-5282.000149
Lemfadli Yassine, A. Hala, Jallouli Abderrahmane, Errami Adil Ait, Oubaha Sofia, Samlani Zouhour, K. Khadija
Gastrointestinal Stromal Tumors (GISTs) are rare tumors of the digestive tract. The small intestine is the second most frequent localization of GIST after the stomach. We report a case of the ileal stromal tumor. The patient was admitted with a picture of hemorrhagic shock due to massive rectal bleeding. The fiberscope performed after stabilization was not objectified at the origin of the document while the CT scan objectified a mass of tissue density at the level of the right iliac fossa. Given the increasing evolution with the recurrence of patients to a target of a laparotomy for diagnostic and therapeutic purposes objectifying the tumor of the right iliac fossa at the expense of the ileum. The surgical procedure consisted of a major segmental resection of the tumor with ileo-ileal anastomosis. The anatomopathological study confirmed the diagnosis of the stromal tumor with good evolution. Through a general review of the literature, we have described the various clinical, para-clinical, anatomopathological, prognostic, and current therapeutic aspects specific to these tumors.
{"title":"Gastrointestinal stromal tumor revealed by hemorrhagic shock","authors":"Lemfadli Yassine, A. Hala, Jallouli Abderrahmane, Errami Adil Ait, Oubaha Sofia, Samlani Zouhour, K. Khadija","doi":"10.17352/2455-5282.000149","DOIUrl":"https://doi.org/10.17352/2455-5282.000149","url":null,"abstract":"Gastrointestinal Stromal Tumors (GISTs) are rare tumors of the digestive tract. The small intestine is the second most frequent localization of GIST after the stomach. We report a case of the ileal stromal tumor. The patient was admitted with a picture of hemorrhagic shock due to massive rectal bleeding. The fiberscope performed after stabilization was not objectified at the origin of the document while the CT scan objectified a mass of tissue density at the level of the right iliac fossa. Given the increasing evolution with the recurrence of patients to a target of a laparotomy for diagnostic and therapeutic purposes objectifying the tumor of the right iliac fossa at the expense of the ileum. The surgical procedure consisted of a major segmental resection of the tumor with ileo-ileal anastomosis. The anatomopathological study confirmed the diagnosis of the stromal tumor with good evolution. Through a general review of the literature, we have described the various clinical, para-clinical, anatomopathological, prognostic, and current therapeutic aspects specific to these tumors.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121541710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.17352/2455-5282.000148
Alkaabba Fahad, Lieutenant H. C. Holman, Ibrahim Farrah
The SARS-CoV-2 pandemic has grown into a major global concern with huge efforts to combat the spread. Exaggerated inflammatory response plays a major role in which was the rationale to use corticosteroids to treat patients. However, multiple studies showed an association between opportunistic and bacterial infections with corticosteroid therapy. We report a case of a 76 year old patient diagnosed with COVID-19 treated with 10 days Dexamethasone and Remdesivir who presented with abdominal symptoms with eosinophilia. Biopsy and stool studies revealed Strongyloides stercoralis larvae. The patient was treated with 2 doses of Ivermectin with significant clinical resolution. Clinician should have high clinical suspicion for Strongloydiasis in patients who have lived or visited endemic areas and for patients with unexplained eosinophilia. Prompt treatment with Ivermectin is crucial for confirmed cases and high risk cases where obtaining a diagnosis is unfeasible.
{"title":"Activating dormant strongyloidiasis secondary to COVID-19 treatment","authors":"Alkaabba Fahad, Lieutenant H. C. Holman, Ibrahim Farrah","doi":"10.17352/2455-5282.000148","DOIUrl":"https://doi.org/10.17352/2455-5282.000148","url":null,"abstract":"The SARS-CoV-2 pandemic has grown into a major global concern with huge efforts to combat the spread. Exaggerated inflammatory response plays a major role in which was the rationale to use corticosteroids to treat patients. However, multiple studies showed an association between opportunistic and bacterial infections with corticosteroid therapy. We report a case of a 76 year old patient diagnosed with COVID-19 treated with 10 days Dexamethasone and Remdesivir who presented with abdominal symptoms with eosinophilia. Biopsy and stool studies revealed Strongyloides stercoralis larvae. The patient was treated with 2 doses of Ivermectin with significant clinical resolution. Clinician should have high clinical suspicion for Strongloydiasis in patients who have lived or visited endemic areas and for patients with unexplained eosinophilia. Prompt treatment with Ivermectin is crucial for confirmed cases and high risk cases where obtaining a diagnosis is unfeasible.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125751490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.17352/2455-5282.000147
M. Ameri, L. Suarez, B. Miles, CF Michie, J. Abdul
Antimicrobial Resistance (AMR) poses an increasing threat to global public health and is projected to be one of the greatest challenges of healthcare in the future as the costs of healthcare, morbidity, and mortality will increase. AMR is likely to complicate many routine procedures such as elective surgery in the future. Together, healthcare professionals need to be aware of the significance antimicrobial resistance poses and make changes needed to mitigate the danger as a result of one of the most important developments in medicine.
{"title":"Antimicrobial resistance: An unrelenting enemy","authors":"M. Ameri, L. Suarez, B. Miles, CF Michie, J. Abdul","doi":"10.17352/2455-5282.000147","DOIUrl":"https://doi.org/10.17352/2455-5282.000147","url":null,"abstract":"Antimicrobial Resistance (AMR) poses an increasing threat to global public health and is projected to be one of the greatest challenges of healthcare in the future as the costs of healthcare, morbidity, and mortality will increase. AMR is likely to complicate many routine procedures such as elective surgery in the future. Together, healthcare professionals need to be aware of the significance antimicrobial resistance poses and make changes needed to mitigate the danger as a result of one of the most important developments in medicine.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114218599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-19DOI: 10.17352/2455-5282.000146
Antunes Paula, Costa Rita, Gorgulho Ana, Marinho António
Spondyloarthropathies are known to affect the interleukin (IL)-17 activation pathway as a basis of their pathology, as is apparent from the literature. Recent studies established the vital role of IL-17 in the treatment of Systemic Lupus Erythematosus (SLE). This article aims to demonstrate the efficacy and safety of IL-17 in the treatment of both spondyloarthropathies and SLE by presenting two cases. The first case concerns a 30-year-old woman who was initially diagnosed with SLE. In the course of the disease, she developed spondyloarthritis and genital psoriasis. She was initially medicated with secukinumab but maintained severe genital psoriasis, the reason it was changed to ixekizumab with great improvement. The second case refers to a 40-year-old woman who previously had spondyloarthropathy with D12 enthesitis and sacroiliitis. Initial treatment with adalimumab led to a lupus-like syndrome, with persistent high systemic inflammatory response syndrome and extreme fatigue. Because of the recrudescence of axial complaints, secukinumab was started and the patient evolved with a global clinical response. Thus, the authors present two cases of spondyloarthropathy and SLE that document the efficacy and safety of IL- 17 blockers, which can lead to the incorporation of these agents in the treatment of SLE.
{"title":"The role of interleukin-17 in spondyloarthropathies and systemic lupus erythematosus: Two clinical cases in real","authors":"Antunes Paula, Costa Rita, Gorgulho Ana, Marinho António","doi":"10.17352/2455-5282.000146","DOIUrl":"https://doi.org/10.17352/2455-5282.000146","url":null,"abstract":"Spondyloarthropathies are known to affect the interleukin (IL)-17 activation pathway as a basis of their pathology, as is apparent from the literature. Recent studies established the vital role of IL-17 in the treatment of Systemic Lupus Erythematosus (SLE). This article aims to demonstrate the efficacy and safety of IL-17 in the treatment of both spondyloarthropathies and SLE by presenting two cases. The first case concerns a 30-year-old woman who was initially diagnosed with SLE. In the course of the disease, she developed spondyloarthritis and genital psoriasis. She was initially medicated with secukinumab but maintained severe genital psoriasis, the reason it was changed to ixekizumab with great improvement. The second case refers to a 40-year-old woman who previously had spondyloarthropathy with D12 enthesitis and sacroiliitis. Initial treatment with adalimumab led to a lupus-like syndrome, with persistent high systemic inflammatory response syndrome and extreme fatigue. Because of the recrudescence of axial complaints, secukinumab was started and the patient evolved with a global clinical response. Thus, the authors present two cases of spondyloarthropathy and SLE that document the efficacy and safety of IL- 17 blockers, which can lead to the incorporation of these agents in the treatment of SLE.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131372426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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