Pub Date : 2017-01-01DOI: 10.5005/jp-journals-10016-1157
S. Nigam, K. Shankar, Thankam R. Varma, K. Rao
{"title":"Role of Low-dose Human Chorionic Gonadotropin in Follicular Phase for Thin Endometrium in Frozen Embryo Replacement Cycles in in vitro Fertilization/ Intracytoplasmic Sperm Injection Patients: A Pilot Study","authors":"S. Nigam, K. Shankar, Thankam R. Varma, K. Rao","doi":"10.5005/jp-journals-10016-1157","DOIUrl":"https://doi.org/10.5005/jp-journals-10016-1157","url":null,"abstract":"","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"37 1","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74766525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/jp-journals-10016-1150
Harsha Bhadarka, NayanaH Patel, K. Patel, Nilofar R. Sodagar, Yuvraj D Jadeja, Niket Patel, M. Patel, Atul Patel, D. Patel, J. Patel, K. Rao
Aim: In recent past, many studies had come up with the combination of time-lapse (TL) imaging of embryo morphokinetics as a noninvasive means for improving embryo selection and in vitro fertilization (IVF) success. The primary objective of the study was to find out if there is significant variation in morphokinetics of embryos with different implantation potential and also to study the effect of sperm freezing on time points of embryogenesis events in embryos with implantation potential. Materials and methods: Kinetic data and cycle outcomes were analyzed retrospectively in 142 patients who had undergone IVF/intracytoplasmic sperm injection (ICSI) cycles using semen with normal parameters and embryo transfer (ET) on day 3. For the surety of specificity of morphokinetics, only cases with single ET cycles were included in the study. Timing of specific events, from the point of ICSI, was determined using TL imaging. Kinetic markers like time to syngamy (t-pnf), t2, time to two cells (c), 3c (t3), 4c (t4), 5c (t5), 8c (t8), tMor, CC2, CC3, t5–t2, t5–t4, s1, s2, and s3 were calculated. The cleavage synchronicity from the 2–8 cell stage (CS2–8), from 4 to 8 cell stage (CS4–8), and from 2 to 4 cell stage (CS2–4) were calculated as defined elsewhere. Deoxyribonucleic acid replication time ratio (DR) was also included RESEARCH ARTiCLE 1Lab Director, 2Gynecologist and Medical Director, 3Senior Embryologist, 4Research Scientist, 5,7Gynecologist, 6Gynecologist and Director, 8Statistician, 9Assistant Professor, 10Former Assistant Professor and Head 1Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India; Department of Biochemistry, P D Patel Institute of Applied Sciences, Changa, Gujarat, India 2,5-7Department of Obstetrics and Gynecology, Akanksha Hospital & Research Institute, Anand, Gujarat, India 3Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India 4Department of Research and Development, Sat Kaival Hospital Private Limited, Anand, Gujarat, India 8Department of Administration, Sardar Patel University, Anand Gujarat, India 9Department of Biotechnology, P D Patel Institute of Applied Sciences, Changa, Gujarat, India 10Department of Biochemistry, P D Patel Institute of Applied Sciences, Changa, Gujarat, India Corresponding Author: Harsha K Bhadarka, Lab Director Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India; Department of Biochemistry, PD Patel Institute of Applied Sciences, Changa, Gujarat, India, Phone: +919727416492, e-mail: harshabhadarka@yahoo.co.in 10.5005/jp-journals-10016-1150 in the comparison. Analysis of variance test was used for comparison of the mean timing of cell division and cell cycle intervals. Results: Morphokinetics t-pnf, t2, t8, CC2, S2, S3, CS2–8, CS4–8, and CS2–4 differed significantly between embryos with and without implantation potential, when embryos were developed using fresh semen, while t3, t4, t5, CC2, S2, t5–t2, CS2–4, and DR differed sign
{"title":"Study of Morphokinetics in Day 3 Embryo with Implantation Potential and Effect of Sperm Cryopreservation on Embryogenesis","authors":"Harsha Bhadarka, NayanaH Patel, K. Patel, Nilofar R. Sodagar, Yuvraj D Jadeja, Niket Patel, M. Patel, Atul Patel, D. Patel, J. Patel, K. Rao","doi":"10.5005/jp-journals-10016-1150","DOIUrl":"https://doi.org/10.5005/jp-journals-10016-1150","url":null,"abstract":"Aim: In recent past, many studies had come up with the combination of time-lapse (TL) imaging of embryo morphokinetics as a noninvasive means for improving embryo selection and in vitro fertilization (IVF) success. The primary objective of the study was to find out if there is significant variation in morphokinetics of embryos with different implantation potential and also to study the effect of sperm freezing on time points of embryogenesis events in embryos with implantation potential. Materials and methods: Kinetic data and cycle outcomes were analyzed retrospectively in 142 patients who had undergone IVF/intracytoplasmic sperm injection (ICSI) cycles using semen with normal parameters and embryo transfer (ET) on day 3. For the surety of specificity of morphokinetics, only cases with single ET cycles were included in the study. Timing of specific events, from the point of ICSI, was determined using TL imaging. Kinetic markers like time to syngamy (t-pnf), t2, time to two cells (c), 3c (t3), 4c (t4), 5c (t5), 8c (t8), tMor, CC2, CC3, t5–t2, t5–t4, s1, s2, and s3 were calculated. The cleavage synchronicity from the 2–8 cell stage (CS2–8), from 4 to 8 cell stage (CS4–8), and from 2 to 4 cell stage (CS2–4) were calculated as defined elsewhere. Deoxyribonucleic acid replication time ratio (DR) was also included RESEARCH ARTiCLE 1Lab Director, 2Gynecologist and Medical Director, 3Senior Embryologist, 4Research Scientist, 5,7Gynecologist, 6Gynecologist and Director, 8Statistician, 9Assistant Professor, 10Former Assistant Professor and Head 1Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India; Department of Biochemistry, P D Patel Institute of Applied Sciences, Changa, Gujarat, India 2,5-7Department of Obstetrics and Gynecology, Akanksha Hospital & Research Institute, Anand, Gujarat, India 3Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India 4Department of Research and Development, Sat Kaival Hospital Private Limited, Anand, Gujarat, India 8Department of Administration, Sardar Patel University, Anand Gujarat, India 9Department of Biotechnology, P D Patel Institute of Applied Sciences, Changa, Gujarat, India 10Department of Biochemistry, P D Patel Institute of Applied Sciences, Changa, Gujarat, India Corresponding Author: Harsha K Bhadarka, Lab Director Department of IVF, Akanksha Hospital & Research Institute Anand, Gujarat, India; Department of Biochemistry, PD Patel Institute of Applied Sciences, Changa, Gujarat, India, Phone: +919727416492, e-mail: harshabhadarka@yahoo.co.in 10.5005/jp-journals-10016-1150 in the comparison. Analysis of variance test was used for comparison of the mean timing of cell division and cell cycle intervals. Results: Morphokinetics t-pnf, t2, t8, CC2, S2, S3, CS2–8, CS4–8, and CS2–4 differed significantly between embryos with and without implantation potential, when embryos were developed using fresh semen, while t3, t4, t5, CC2, S2, t5–t2, CS2–4, and DR differed sign","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"48 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80300792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1146
S. Rathinam, R. Rudrappa, B. Talluri, K. Rao
Aim: To enlighten the readers regarding rare and distinct presentation of fetal encephalocele in parietal location and its significance. Background: Cranium bifidum is a defect in the cranium through which there can be herniation of intracranial contents. If the content of herniation is meninges, it is called meningocele and if it contains brain tissue in addition to meninges, it is called meningoencephalocele or encephalocele. The incidence of encephalocele is 1 in 4,000 live births. The most common location is the occipital region (75%) followed by frontoethmoidal (15%), which is common in Asian population, and rarest is the basal followed by parietal locations. The exact incidence of parietal encephalocele is not available due to its rarity. Case report: We present a case of a 24-year-old primigravida female in second trimester who came for antenatal scan to rule out anomalies. On examination by ultrasonography, we found a large cerebriform soft tissue herniating through a defect in skull vault from the vertex region with secondary microcephaly. Conclusion: Here we give an overview of rarest form of encephalocele in parietal region, which grossly differs from the already reported parietal encephaloceles of atretic type presenting as small skin-covered subscalp lesions that contain Meninges and neural and glial rests. In our case, the encephalocele was distinct, being larger in size with normal brain parenchyma as the major content of the herniating sac. Clinical significance: Only few cases of parietal encephalocele is reported in the literature, that too of atretic type. Apart from being the rarest form, this variant is found to be associated with poor prognosis.
{"title":"Parietal Cranium Bifidum: A Rare Presentation","authors":"S. Rathinam, R. Rudrappa, B. Talluri, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1146","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1146","url":null,"abstract":"Aim: To enlighten the readers regarding rare and distinct presentation of fetal encephalocele in parietal location and its significance. Background: Cranium bifidum is a defect in the cranium through which there can be herniation of intracranial contents. If the content of herniation is meninges, it is called meningocele and if it contains brain tissue in addition to meninges, it is called meningoencephalocele or encephalocele. The incidence of encephalocele is 1 in 4,000 live births. The most common location is the occipital region (75%) followed by frontoethmoidal (15%), which is common in Asian population, and rarest is the basal followed by parietal locations. The exact incidence of parietal encephalocele is not available due to its rarity. Case report: We present a case of a 24-year-old primigravida female in second trimester who came for antenatal scan to rule out anomalies. On examination by ultrasonography, we found a large cerebriform soft tissue herniating through a defect in skull vault from the vertex region with secondary microcephaly. Conclusion: Here we give an overview of rarest form of encephalocele in parietal region, which grossly differs from the already reported parietal encephaloceles of atretic type presenting as small skin-covered subscalp lesions that contain Meninges and neural and glial rests. In our case, the encephalocele was distinct, being larger in size with normal brain parenchyma as the major content of the herniating sac. Clinical significance: Only few cases of parietal encephalocele is reported in the literature, that too of atretic type. Apart from being the rarest form, this variant is found to be associated with poor prognosis.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"36 1","pages":"41-44"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86536356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1145
Puspal De, S. Chakravarty, A. Chakravarty, K. Rao
{"title":"Pre- and Postnatal Genetic Evaluation reduce the Reproductive Risk of nonhomologous Robertsonian Translocation Carrier Couple","authors":"Puspal De, S. Chakravarty, A. Chakravarty, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1145","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1145","url":null,"abstract":"","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"12 1","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75257482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1148
S. Nigam, I. Joy, K. Shankar, Thankam R. Varma, K. Rao
Introduction: In assisted reproduction technique cycles, controlled ovarian stimulation (COS) leads to supraphysiological levels of steroid hormone secretion and the subsequent need for luteal phase support (LPS). Therefore, existing data on the steroid secretion profile in the luteal phase of spontaneous conception cycles and its predictive value for pregnancy outcome need to be discussed against the background of preceding COS. The clinical significance of luteal phase hormones, such as estrogen (E2) and progesterone (P4), in predicting pregnancy after controlled ovarian hyperstimulation protocols for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is still poorly understood. The aim of the present study was to investigate the role of midluteal serum E2 and P4 level in predicting successful pregnancy in patients undergoing IVF/ICSI. Materials and methods: One hundred fifteen women were recruited for the study. They were given gonadotropin-releasing hormone antagonist protocol and human chorionic gonadotropin (hCG) was administered if at least three follicles were more than 18 mm in size. Transvaginal ultrasound-guided oocyte retrieval followed by ICSI and embryo transfer (ET) was done. Post-ET, all women had same LPS. The E2 and P4 measurements were done at day of ET (day 0) and 9 days post-ET (day 9). Levels of E2 and P4 were compared between those who subsequently became pregnant and those who could not achieve pregnancy. Statistical analysis was performed using Statistical Package for the Social Sciences. Results: Forty-six (40%) achieved pregnancy. The E2 and P4 levels on day 9 were significantly higher in those who achieved pregnancy (p < 0.01). Out of 46 pregnancies, 38 were ongoing viable pregnancies. Conclusion: Luteal phase E2 and P4 can be used as prognostic marker to predict pregnancy in IVF/ICSI cycles.
{"title":"Midluteal Serum Estrogen and Progesterone Levels predict Pregnancy Rate in in vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Prospective Study","authors":"S. Nigam, I. Joy, K. Shankar, Thankam R. Varma, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1148","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1148","url":null,"abstract":"Introduction: In assisted reproduction technique cycles, controlled ovarian stimulation (COS) leads to supraphysiological levels of steroid hormone secretion and the subsequent need for luteal phase support (LPS). Therefore, existing data on the steroid secretion profile in the luteal phase of spontaneous conception cycles and its predictive value for pregnancy outcome need to be discussed against the background of preceding COS. The clinical significance of luteal phase hormones, such as estrogen (E2) and progesterone (P4), in predicting pregnancy after controlled ovarian hyperstimulation protocols for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is still poorly understood. The aim of the present study was to investigate the role of midluteal serum E2 and P4 level in predicting successful pregnancy in patients undergoing IVF/ICSI. Materials and methods: One hundred fifteen women were recruited for the study. They were given gonadotropin-releasing hormone antagonist protocol and human chorionic gonadotropin (hCG) was administered if at least three follicles were more than 18 mm in size. Transvaginal ultrasound-guided oocyte retrieval followed by ICSI and embryo transfer (ET) was done. Post-ET, all women had same LPS. The E2 and P4 measurements were done at day of ET (day 0) and 9 days post-ET (day 9). Levels of E2 and P4 were compared between those who subsequently became pregnant and those who could not achieve pregnancy. Statistical analysis was performed using Statistical Package for the Social Sciences. Results: Forty-six (40%) achieved pregnancy. The E2 and P4 levels on day 9 were significantly higher in those who achieved pregnancy (p < 0.01). Out of 46 pregnancies, 38 were ongoing viable pregnancies. Conclusion: Luteal phase E2 and P4 can be used as prognostic marker to predict pregnancy in IVF/ICSI cycles.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"1 1","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89760183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1139
S. Balasubramanyam, K. Rao
{"title":"Sequential Use of Testosterone Gel and Growth Hormone in Expected Poor Responders and those with Previous Poor Assisted Reproductive Technology Outcomes: A Pilot Study","authors":"S. Balasubramanyam, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1139","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1139","url":null,"abstract":"","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82458010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1153
Vaibhav Kumar, G. Sharma, Saherish Khan, A. Singhania, Shraddha Singhania, K. Rao
Purpose: To evaluate clinically suspected cases of intrauterine growth restriction (IUGR) for Doppler study of uterine artery, umbilical artery, and fetal middle cerebral artery. To compare the various indices of the three vessels in predicting perinatal outcome. To evaluate the positive predictive value among these parameters. To compare the Doppler findings with fetal outcome. Materials and methods: One hundred and two singleton pregnancies complicated by IUGR and severe preeclampsia or both were prospectively examined with Doppler ultrasound of the umbilical artery, middle cerebral artery, and umbilical vein which were compared with 104 uncomplicated pregnancies that formed the control group. Observation and Results: One hundred and two singleton pregnancies included in the study population had at least one major or minor adverse outcome. Major adverse outcome criteria included perinatal deaths – including intrauterine and early neonatal deaths, etc. Minor outcomes included cesarean delivery for fetal distress, APGAR score below 7 at 5 minutes, and admission to neonatal intensive care unit for treatment. Conclusion: Low diastolic and high indices characterize the pregnancies with abnormal outcomes. The uterine artery had a better sensitivity and specificity as compared with the umbilical arteries and diastolic notch had the highest sensitivity and specificity. Doppler also provides a noninvasive method of assessing the fetal and maternal circulation during pregnancy.
{"title":"Study of the Significance of Fetal Doppler Flow Velocimetry in the Perinatal Outcome of Growth-restricted Fetuses","authors":"Vaibhav Kumar, G. Sharma, Saherish Khan, A. Singhania, Shraddha Singhania, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1153","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1153","url":null,"abstract":"Purpose: To evaluate clinically suspected cases of intrauterine growth restriction (IUGR) for Doppler study of uterine artery, umbilical artery, and fetal middle cerebral artery. To compare the various indices of the three vessels in predicting perinatal outcome. To evaluate the positive predictive value among these parameters. To compare the Doppler findings with fetal outcome. Materials and methods: One hundred and two singleton pregnancies complicated by IUGR and severe preeclampsia or both were prospectively examined with Doppler ultrasound of the umbilical artery, middle cerebral artery, and umbilical vein which were compared with 104 uncomplicated pregnancies that formed the control group. Observation and Results: One hundred and two singleton pregnancies included in the study population had at least one major or minor adverse outcome. Major adverse outcome criteria included perinatal deaths – including intrauterine and early neonatal deaths, etc. Minor outcomes included cesarean delivery for fetal distress, APGAR score below 7 at 5 minutes, and admission to neonatal intensive care unit for treatment. Conclusion: Low diastolic and high indices characterize the pregnancies with abnormal outcomes. The uterine artery had a better sensitivity and specificity as compared with the umbilical arteries and diastolic notch had the highest sensitivity and specificity. Doppler also provides a noninvasive method of assessing the fetal and maternal circulation during pregnancy.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"13 1","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88935693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1141
M. Jaffar, Mohammed C. Ashraf, K. Rao
Objective: To determine whether weight loss in obese men improves seminal parameters. Design: Prospective interventional study. Setting: Infertility clinic and weight loss centers. Patient: All men attending infertility center and weight loss programmes from April 2012 to May 2015 (n = 105). Intervention: Diet counseling and exercise. Main Outcome Measure: Collected reproductive parameters included semen analysis (ejaculate volume, sperm concentration, progressive and non-progressive motility) data. Body mass index (BMI) was calculated for all patients with comparisons to reproductive parameters before and after weight loss by using paired-t test and Chi-square tests. Result: The mean BMI was significantly higher before weight loss (33.2) than after weight loss (30.4) in obese men. The weight loss had significant positive correlation with percentage of progressive sperm motility (p = < 0.001) and static percentage (p = < 0.001). Weight loss had non-significant correlation with semen volume (p = 0.083), concentration (p = 0.418) and non progressive motile sperm (p = 0.361). Conclusion: In one of the largest cohorts of male fertility and obesity, semen parameters demonstrated mild but significant relationships with BMI and semen parameters, possibly contributing to subfertility in this population.
{"title":"Does Weight Loss improve Fertility with respect to Semen Parameters— Results from a Large Cohort Study","authors":"M. Jaffar, Mohammed C. Ashraf, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1141","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1141","url":null,"abstract":"Objective: To determine whether weight loss in obese men improves seminal parameters. Design: Prospective interventional study. Setting: Infertility clinic and weight loss centers. Patient: All men attending infertility center and weight loss programmes from April 2012 to May 2015 (n = 105). Intervention: Diet counseling and exercise. Main Outcome Measure: Collected reproductive parameters included semen analysis (ejaculate volume, sperm concentration, progressive and non-progressive motility) data. Body mass index (BMI) was calculated for all patients with comparisons to reproductive parameters before and after weight loss by using paired-t test and Chi-square tests. Result: The mean BMI was significantly higher before weight loss (33.2) than after weight loss (30.4) in obese men. The weight loss had significant positive correlation with percentage of progressive sperm motility (p = < 0.001) and static percentage (p = < 0.001). Weight loss had non-significant correlation with semen volume (p = 0.083), concentration (p = 0.418) and non progressive motile sperm (p = 0.361). Conclusion: In one of the largest cohorts of male fertility and obesity, semen parameters demonstrated mild but significant relationships with BMI and semen parameters, possibly contributing to subfertility in this population.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"114 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88027864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5005/JP-JOURNALS-10016-1154
S. Bhat, R. Nambiar, D. Nayak, Krupa H Shah, K. Rao
{"title":"Prenatal diagnosis and postnatal management of congenital pulmonary airway malformation","authors":"S. Bhat, R. Nambiar, D. Nayak, Krupa H Shah, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1154","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1154","url":null,"abstract":"","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"10 1","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87932493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-01DOI: 10.5005/JP-JOURNALS-10016-1135
G. Pallavi, P. Pai, Pratap Kumar, Arun Maiyya, Preetha Ramachandra
Aims: To determine the body fat distribution in 30 women with polycystic ovarian syndrome (PCOS) using bioelectric impedance analysis (BIA) and assess the effect of a 2-month structured exercise on body fat, menstrual function and fertility outcomes.Materials and methods: Thirty women with PCOS underwent assessment of body composition with BIA. Their body mass index (BMI), total body fat (TBF), visceral fat (VF) and subcutaneous fat were analyzed. Two-month structured exercises were advised based on individual exercise tolerance. The postexercise parameters were reassessed. Outcome measures studied were improvement in BMI, TBF, VF, subcutaneous fat,menstrual functions and fertility outcomes.Results: A significant reduction in BMI, VF and subcutaneous fat was found in these women after exercise. Results were further analyzed after dividing them into three groups based on their BMI (normal, overweight, and obese). There was a significant reduction in all parameters (BMI, TBF, visceral and subcutaneous fat) in the overweight group. In the obese group, there was a significant drop in BMI and VF and to a lesser extent in the TBF. In women with normal BMI, a significant drop was noted in TBF only. On follow-up, five women reported regularization of their menstrual cycles and four others managed to conceive.Conclusion: Total body fat and VF can be cost-effectively measured by a simple tool called BIA. Tailor-made exercises based on individual tolerance are effective in improving these parameters even when done over a short duration. These improvements do positively impact the menstrual dysfunctions and subfertility.Clinical significance: These findings will help in better management of women with PCOS and ensure optimal improvement in menstrual dysfunction and fertility outcomes.
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