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Journal of Kerman University of Medical Sciences最新文献

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Maternal Serological Screening for Congenital Toxoplasmosis During Pregnancy and Evaluating the Pregnant Women’s Knowledge on Toxoplasmosis in Qazvin, Iran 伊朗加兹温孕妇妊娠期先天性弓形虫病血清学筛查及弓形虫病知识评估
Q4 Medicine Pub Date : 2022-10-31 DOI: 10.34172/jkmu.2022.52
Siavash Abdi Gheshlaghi, Zahra Babaeinejad, M. Saraei, N. Mohammadi, E. Hajialilo, A. Javadi, Peyman Heydarian, F. Samieerad
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引用次数: 0
The Effect of Metacognitive Therapy on Treatment Adherence and Life Expectancy of Patients with Gastrointestinal Cancers 元认知疗法对胃肠道肿瘤患者治疗依从性和预期寿命的影响
Q4 Medicine Pub Date : 2022-10-31 DOI: 10.34172/jkmu.2022.58
Faraz Tayyar-Iravanlou, Seyedeh Narjes Mousavizadeh, J. Mohtashami, M. Nasiri
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引用次数: 4
Exposure of Healthy Adult Male Rats to Dust Storm Impairs Cognition, Anxiety, Locomotion and Depression-like Behaviors by Stimulation of Brain Neuroinflammation and Oxidative Stress 健康成年雄性大鼠暴露于沙尘暴环境中通过刺激脑神经炎症和氧化应激影响认知、焦虑、运动和抑郁样行为
Q4 Medicine Pub Date : 2022-10-31 DOI: 10.34172/jkmu.2022.56
Somayeh Hajipour, Y. Farbood, S. Khoshnam, G. Goudarzi, M. Rashno, Heidar Maleki, N. Bakhtiari, Behjat Sarkaki, A. Sarkaki
Background: T Exposure of normal subjects to dust storm (DS) with different doses of ambient air-born dusty particulate matter (PM) causes memory and locomotion impairment, anxiety and depression-like behaviors. This study was designed to investigate the effect of sub-chronic exposure to DS with inhalation of ambient PM in a designed special chamber on cognition, anxiety, depression, locomotion behaviors, brain tissue inflammatory cytokines and antioxidant indices in healthy adult rats. Methods: Adult male Wistar rats (250-300 g) were divided randomly into the 4 groups: Sham (clean air, contains the least dusty PM < 150 µg/m 3 ), DS1 (200-500 µg/m 3 PM), DS2 (500-2000 µg/m 3 PM) and DS3 (2000- 8000 µg/m 3 PM). Rats were exposed to the clean air or different sizes and concentrations of PM in DS during the first 4 consecutive days of each week in an experimental actual-ambient dust exposure chamber. Results: Sub-chronic exposing to dust storm PM impaired avoidance memory and locomotion, increased anxiety and depression like behaviors. These disturbances were in line with increased levels of inflammatory cytokines in brain tissue and suppressing the antioxidant indexes. Conclusion: Current findings indicated that exposure to ambient PM due to DS caused cognitive, anxiety, depression-like and locomotion behaviors impairment by increasing the neuroinflammatory responses and suppressing the antioxidant indexes in the brain.
背景:正常人暴露于不同剂量的沙尘暴(DS)环境空气中粉尘颗粒(PM)会导致记忆和运动障碍、焦虑和抑郁样行为。本研究旨在探讨亚慢性暴露DS并在设计的特殊室中吸入环境PM对健康成年大鼠认知、焦虑、抑郁、运动行为、脑组织炎症因子和抗氧化指标的影响。方法:将成年雄性Wistar大鼠(250 ~ 300 g)随机分为4组:Sham组(空气清新,含尘最少的PM < 150µg/m 3)、DS1组(200 ~ 500µg/m 3 PM)、DS2组(500 ~ 2000µg/m 3 PM)和DS3组(2000 ~ 8000µg/m 3 PM)。将大鼠于每周连续4天在实验环境粉尘暴露室内暴露于洁净空气或不同大小和浓度的DS中PM。结果:亚慢性暴露于沙尘暴PM会损害回避记忆和运动,增加焦虑和抑郁样行为。这些干扰与脑组织中炎症细胞因子水平的增加和抗氧化指标的抑制一致。结论:目前的研究结果表明,退行性痴呆导致的环境PM暴露通过增加神经炎症反应和抑制大脑抗氧化指标而导致认知、焦虑、抑郁样和运动行为障碍。
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引用次数: 0
Does Vitamin D Administration Increase the Neuroprotective Effect of Estrogen in Male Rats with Traumatic Brain Injury? 维生素D给药是否增加雌激素对雄性大鼠脑损伤的神经保护作用?
Q4 Medicine Pub Date : 2022-10-31 DOI: 10.34172/jkmu.2022.53
A. Alinaghi Langari, Nazanin Sabet, Hamideh Bashiri, Sobhan Mohammadi Jorjafki, Reyhaneh Rezaie, Nafiseh Esmaeilpour, Sedigheh Amiresmaili, M. Khaksari, Shahryar Dabiri, Mahmoud Amiri, Z. Soltani
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引用次数: 1
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Journal of Kerman University of Medical Sciences
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