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Tuberculosis pulmonar: la epidemia mundial continúa y la enseñanza de este tema resulta crucial y compleja 肺结核:全球流行病仍在继续,这一主题的教学至关重要和复杂
Q4 Social Sciences Pub Date : 2017-01-01 DOI: 10.1016/j.eq.2016.09.009
Raúl Garza-Velasco , Jacqueline Ávila-de Jesús , Luis Manuel Perea-Mejía

Understanding of tuberculosis (TB) requires students to identify some critical points. The disease is caused by Mycobacterium tuberculosis, a peculiar bacterium mainly transmitted by inhaling infectious droplets expelled when coughing, talking and sneezing. One of the least understood aspects is that, following the exposure to the infectious droplets, a third of the people develop a latent pulmonary infection. The last means that some people control, rather than eliminate, the bacteria; therefore, some of them can later develop the TB disease, especially when they present an immunological deficiency. The key is to recognize the cell-mediated immunity as a determining factor in the course of the latent or active infection and that the antibodies, the complement system and the phagocytosis by non-activated macrophages result irrelevant in the defense against TB.

Another major concern is the effect of multidrug resistant and extensively drug resistant strains. Management of multidrug resistant -TB and extensively drug resistant -TB is more complicated due the long treatment periods and the elevated costs.

了解结核病(TB)要求学生识别一些关键点。这种疾病是由结核分枝杆菌引起的,结核分枝杆菌是一种特殊的细菌,主要通过吸入咳嗽、说话和打喷嚏时喷出的传染性飞沫传播。其中一个最不为人所知的方面是,在接触传染性飞沫后,三分之一的人会出现潜伏性肺部感染。最后一种方法意味着有些人控制而不是消灭细菌;因此,他们中的一些人后来会发展成结核病,特别是当他们出现免疫缺陷时。关键是要认识到细胞介导的免疫在潜伏性或活动性感染过程中是一个决定性因素,而抗体、补体系统和非活化巨噬细胞的吞噬作用与结核病的防御无关。另一个主要问题是多重耐药和广泛耐药菌株的影响。耐多药结核病和广泛耐药结核病的管理由于治疗周期长和费用高而更加复杂。
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引用次数: 3
Descubrimiento y desarrollo de fármacos: un enfoque computacional 药物发现与开发:计算方法
Q4 Social Sciences Pub Date : 2017-01-01 DOI: 10.1016/j.eq.2016.06.002
Fernanda Saldívar-González, Fernando D. Prieto-Martínez, José L. Medina-Franco

Drug discovery is a complex and expensive process where different research areas converge. Computational methods have been part of the multidisciplinary efforts and their principles should be included in courses of Medicinal Chemistry. In a given project, the application of computational approaches depends on the information available for the system and the specific goals of the study. Computational approaches have made key contributions to perform efficient analyses of data, filtering compounds collections to select molecules for experimental screening, generate hypothesis to understand the mechanism of action of drugs, and the design of new chemical structures. In addition, computational methods have made significant contributions to develop drugs that are in clinical use. However, there are several challenges to face. Addressing these challenges promote innovation and improvement of methodologies that form part of the multidisciplinary effort to develop drugs.

药物发现是一个复杂而昂贵的过程,不同的研究领域汇聚在一起。计算方法已成为多学科努力的一部分,其原理应包括在药物化学课程中。在给定的项目中,计算方法的应用取决于系统可用的信息和研究的具体目标。计算方法在执行有效的数据分析,过滤化合物集合以选择用于实验筛选的分子,生成假设以了解药物的作用机制以及设计新的化学结构方面做出了关键贡献。此外,计算方法对开发临床使用的药物做出了重大贡献。然而,有几个挑战需要面对。应对这些挑战可促进方法的创新和改进,这些方法是开发药物的多学科努力的一部分。
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引用次数: 17
Wikis en Moodle: la mirada de estudiantes y docentes Moodle中的维基:学生和老师的观点
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.08.001
Ivana Núñez , Marina Míguez , Gustavo Seoane

The use of ICT in education does not imply innovation per se, since these technologies can be used to maintain immutable educational models, and therefore the adequacy and scope of the incorporation must be analyzed. In order to provide elements for the reflection on the possibilities of incorporating tools to support teaching and learning processes, the results from an investigation carried out within the Department of Organic Chemistry of the Faculty of Chemistry, Universidad de la República, are analyzed. This paper discusses the use of wikies as a tool for the Organic Chemistry Laboratory course corresponding to the third year of all careers offered by the Faculty of Chemistry (Universidad de la República) through the students’ reports, the platform registers and the opinions expressed by the course participants.

在教育中使用信通技术本身并不意味着创新,因为这些技术可以用来维持不变的教育模式,因此必须分析这种结合的适当性和范围。为了提供关于整合工具来支持教学和学习过程的可能性的反思元素,分析了在universsidad de la República化学系有机化学系进行的调查结果。本文通过学生的报告、平台注册和课程参与者的意见,讨论了在化学系(universsidad de la República)所有职业所提供的三年级有机化学实验课程中使用wiki作为工具的问题。
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引用次数: 2
Reproducción de un ambiente de innovación en el salón de clase. Una estrategia para promover la creatividad en la educación en Ingeniería Química 在课堂上再现创新的氛围。促进化学工程教育创造力的策略
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.07.001
Ronald Márquez, Laura Tolosa, Rubén Gómez, César Izaguirre, Leonardo Rennola, Johnny Bullón, Beatriz Sandia

The teaching-learning process in traditional college education uses strategies that place the student as a recipient of information transmitted by the teacher, which is conceptualized as knowledge. The reality in which we live requires generating training solutions to meet the needs of individuals in the development of skills or know-how to respond to society, to form individuals capable of learning to learn and learning to transfer, prepared to continually seek knowledge and able to create and innovate. In this paper, the results of the implementation of the strategy ‘Reproducing an Innovation Environment in the Classroom’ (RAIS) in courses of the Chemical Engineering curriculum, in Universidad de Los Andes, Mérida-Venezuela are presented. This is a strategy of teaching, learning and assessment in which the student is a co-participant in the construction and generation of knowledge, developing the skills proposed in the course by the execution of a product. RAIS strategy was applied in the courses of Physical Chemistry for Chemical Engineers, Industrial Chemistry I and Laboratory of Industrial Chemistry, where students obtained a finished product using the know-how in the area of each course. This strategy led to an increase in motivation over other courses based on lectures, and the development of the ability to function and find solutions in multidisciplinary groups workplaces. It is important to note that more than 80% of students said the RAIS strategy contributes to their personal development and training for applied research.

传统大学教育的教学过程使用的策略是将学生作为教师传递的信息的接受者,这些信息被概念化为知识。我们所生活的现实需要产生培训解决方案,以满足个人在发展技能或专门知识方面的需求,以对社会作出反应,形成能够学习学习和学习转移的个人,准备不断寻求知识并能够创造和创新。在这篇论文中,介绍了在委内瑞拉的洛斯安第斯大学化学工程课程中实施“再现课堂创新环境”(RAIS)战略的结果。这是一种教学、学习和评估的策略,在这种策略中,学生是知识的构建和生成的共同参与者,通过产品的执行来发展课程中提出的技能。RAIS策略应用于化学工程师物理化学、工业化学I和工业化学实验室课程,学生利用每门课程领域的专业知识获得成品。这一策略导致了动力的增加,而不是其他基于讲座的课程,以及在多学科团体工作场所中发挥作用和寻找解决方案的能力的发展。值得注意的是,超过80%的学生表示RAIS策略有助于他们的个人发展和应用研究培训。
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引用次数: 9
Producción de radiofármacos para tomografía por emisión de positrones (PET) y su aplicación en el diagnóstico de diversas enfermedades 正电子发射断层摄影术(PET)放射性药物的生产及其在各种疾病诊断中的应用
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.04.005
Adolfo Obaya Valdivia, Jesús López López, Yolanda Marina Vargas-Rodríguez, Oyuki Camacho González

The radioactivity is more known for adverse effects by the explosion of atomic bombs in World War II, but also has features beneficial to health care since it serves for the early diagnosis of diseases to your treatment. This paper presents, from a perspective of chemical education, the fundamental concepts of the Emission of Positron Tomography (PET). Also explains the process of production of radiopharmaceuticals for PET, in particular 18F. Also, different types of radiopharmaceuticals used for diagnosis of oncological, neurological and cardiac diseases are discussed. The use and clinical applications of this method of Imaging is already a reality in Mexico since 2005. It is expected students and teachers of the area chemical biological sciences achieve a better understanding and an overview of the scope and applications that this technique can have.

放射性更广为人知的是第二次世界大战中原子弹爆炸的不良影响,但它也有对医疗保健有益的特点,因为它有助于疾病的早期诊断和治疗。本文从化学教育的角度,介绍了正电子断层扫描(PET)发射的基本概念。还解释了生产PET的放射性药物的过程,特别是18F。此外,还讨论了用于诊断肿瘤、神经和心脏疾病的不同类型的放射性药物。自2005年以来,这种成像方法的使用和临床应用在墨西哥已经成为现实。期望化学生物科学领域的学生和教师对该技术的范围和应用有更好的理解和概述。
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引用次数: 3
Henry Enfield Roscoe 亨利·恩菲尔德·罗斯科
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2015.09.012
Jaime Wisniak

Henry Enfield Roscoe (1833–1915), together with Robert Bunsen, his mentor, carried on fundamental research in photochemistry, determining its laws and quantitative effects. His most important studies were on the chemistry of vanadium, uranium, tungsten, and molybdenum, their oxides and oxychlorides, carrying on, for the first time, their synthesis and separation. He also did important studies on public heath. His academic activities transformed Owens College (Victoria University) into the leading chemistry school in Britain.

亨利·恩菲尔德·罗斯科(1833-1915)和他的导师罗伯特·本生一起进行了光化学的基础研究,确定了光化学的规律和定量效应。他最重要的研究是钒、铀、钨和钼的化学性质,以及它们的氧化物和氯氧化物,并首次进行了它们的合成和分离。他还对公共卫生做了重要的研究。他的学术活动使欧文斯学院(维多利亚大学)成为英国领先的化学学校。
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引用次数: 1
Árbitros de Educación Química 化学教育裁判
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.09.007
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引用次数: 0
La nanomedicina y los sistemas de liberación de fármacos: ¿la (r)evolución de la terapia contra el cáncer? 纳米医学和药物释放系统:癌症治疗的(r)进化?
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.07.002
Yareli Rojas-Aguirre, Karina Aguado-Castrejón, Israel González-Méndez

The term nanotechnology refers to a number of disciplines intended to study materials and structures at the nanoscale. One of the most important areas of nanotechnology is nanomedicine, which is focused in great extent on the design and development of drug delivery systems. These drug delivery platforms can display very sophisticated properties and unique features, and are considered as the revolution of the conventional chemotherapies, specifically those to treat cancer. In this work we review the concept of nanomedicine and its application on the design of nanocarriers of antineoplastic drugs and highlight some aspects that have to be addressed to translate the drug delivery platforms in to devices with possibilities to reach clinical trials.

纳米技术这个术语指的是一些旨在研究纳米尺度上的材料和结构的学科。纳米技术最重要的领域之一是纳米医学,它在很大程度上集中在药物输送系统的设计和开发上。这些给药平台可以显示出非常复杂的特性和独特的特征,被认为是传统化疗的革命,特别是治疗癌症的化疗。在这项工作中,我们回顾了纳米医学的概念及其在抗肿瘤药物纳米载体设计中的应用,并强调了将药物输送平台转化为有可能达到临床试验的设备必须解决的一些方面。
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引用次数: 8
Fe de erratas 勘误
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.09.006
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引用次数: 0
Logros y perspectivas de la Química Teórica 理论化学的成就与展望
Q4 Social Sciences Pub Date : 2016-10-01 DOI: 10.1016/j.eq.2016.09.001
Alberto Vela

A review of the methods developed within Theoretical Chemistry to study matter in many spatial and temporal scales is presented. The scientific career of a well known theoretical chemist is used to show how the astonishing advances that have been achieved in four decades in the development of theories, codes (algorithms) and computer technology allow nowadays the reliable study of the electronic structure of systems whose sizes were unmanageable forty years ago. It is emphasized that the central difficulty in studying Chemistry from a theoretical perspective is that, in every scale, one deals with a many-body problem whose solution and comprehension are still an unsolved and fascinating scientific challenge.

回顾了理论化学中发展起来的研究物质在许多空间和时间尺度的方法。一位著名的理论化学家的科学生涯被用来说明四十年来在理论、密码(算法)和计算机技术的发展方面取得的惊人进展如何使今天能够可靠地研究四十年前难以控制的系统的电子结构。本文强调,从理论角度研究化学的主要困难在于,在每一个尺度上,人们都要处理一个多体问题,其解决和理解仍然是一个未解决的、令人着迷的科学挑战。
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引用次数: 0
期刊
Educacion Quimica
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