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Fabrication and experimental investigation of a porous zinc alloy structure 多孔锌合金结构的制备与实验研究
Q4 Engineering Pub Date : 2017-10-16 DOI: 10.1504/IJMSI.2017.10008164
A. Chaturvedi, S. Chaturvedi
A porous structure has been designed and fabricated to generate very regular shaped pores. The porous structure has 20% porosity with a relative density of 0.8. Radiographic examinations conducted on the samples confirmed regular shaped porous structure throughout. Compression testings were carried out on the samples at three different strain rates viz. 7.93 × 10e-5/ sec, 7.93 × 10e-4/ sec and 3.96 × 10e-2/ sec respectively and the nominal stress-nominal strain graphs were plotted with 0.2% proof strength taken as the onset of yield in the structure, the testing revealed an approximately elasto-plastic strain rate sensitive response behaviour in the yield strength as well as plateau region of the porous samples. Energy absorption analysis was carried out up to ≅0.25 strain. The method described in this paper can be used to generate and study different kinds of porous structures.
已经设计和制造了多孔结构以产生非常规则形状的孔。多孔结构具有20%的孔隙率,相对密度为0.8。对样品进行的射线照相检查证实了整个样品具有规则形状的多孔结构。分别在7.93×10e-5/sec、7.93×10de-4/sec和3.96×10e-2/sec三种不同应变速率下对样品进行了压缩试验,并绘制了标称应力-标称应变图,其中0.2%的验证强度作为结构的屈服起点,测试表明,多孔样品的屈服强度和平台区具有近似弹塑性应变率敏感的响应行为。进行了能量吸收分析,直至应变达到?.25。本文所描述的方法可用于生成和研究不同类型的多孔结构。
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引用次数: 0
A discussion and prediction on thermal transfer of interface structure in micro/nano manufacturing 微纳制造中界面结构热传递的讨论与预测
Q4 Engineering Pub Date : 2017-10-16 DOI: 10.1504/IJMSI.2017.10008105
Bing Yang, Yuan Xiao, X. Zhou, Wei Gao, Ping Yang
Interface structure is a critical part of electronic components in computers, smart phones, automotive components and other electronic devices. Along with the development of technologies, the demand for electronic devices and their quality has increased rapidly in recent years. Thus, it is indispensable to study the thermal transfer of interface structure. In this article, we give a review of recent investigations on the thermal transfer of interface structure in micro/nano manufacturing. The research method is an important part of scientific research. Therefore, many research methods are listed in this paper. Some academic developments on design and reliability of interface structure by considering thermal characteristics under different loading conditions are also discussed.
接口结构是计算机、智能手机、汽车零部件和其他电子设备中电子元件的关键部分。近年来,随着技术的发展,对电子设备及其质量的需求迅速增长。因此,研究界面结构的热传递是必不可少的。本文综述了近年来在微/纳米制造中界面结构热传递的研究进展。研究方法是科学研究的重要组成部分。因此,本文列举了许多研究方法。还讨论了在考虑不同载荷条件下的热特性的界面结构设计和可靠性方面的一些学术进展。
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引用次数: 2
Flow behaviours and boundary slip of nitrogen-oxygen mixture confined in nanochannel 纳米通道中氮氧混合物的流动行为和边界滑移
Q4 Engineering Pub Date : 2017-10-16 DOI: 10.1504/IJMSI.2017.10008108
Zhongqiang Zhang, Maolei Hao, Zhen Liu, G. Cheng, Jianning Ding
Molecular dynamics simulations have been carried out to study the Couette flow of nitrogen-oxygen mixture confined in parallel-plate nanochannels. The simulation results show that the shear stress linearly increases with the increase of the shear rate when the channel width is a constant, implying that the shear viscosity of the gas flow is constant in our simulations, which increases with the channel width. However, as the channel width reaches a threshold, the effect of channel width on fluid viscosity decreases gradually. The slip velocity decreases with increasing the solid-gas coupling strength and the number density of the gas molecules. Interestingly, the shear viscosity of fluid confined in the nanochannels increases with enlarging the component ratio of nitrogen. The particular issue at nanoscale is that the solid-like structure is extremely easy to form at the gas flow boundaries for the nitrogen molecules confined in the parallel-plate nanochannels.
采用分子动力学方法研究了氮氧混合物在平行板纳米通道内的Couette流动。模拟结果表明,当通道宽度一定时,剪切应力随剪切速率的增加而线性增加,这意味着在模拟中气流的剪切粘度是恒定的,随通道宽度的增加而增加。但当通道宽度达到一定阈值时,通道宽度对流体粘度的影响逐渐减小。滑移速度随固气耦合强度和气体分子数密度的增加而减小。有趣的是,限制在纳米通道内的流体的剪切粘度随着氮组分比的增大而增加。在纳米尺度上的特殊问题是,被限制在平行板纳米通道中的氮分子极容易在气体流动边界处形成类固体结构。
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引用次数: 0
Elevated basal antibody-dependent cell-mediated cytotoxicity (ADCC) and high epidermal growth factor receptor (EGFR) expression predict favourable outcome in patients with locally advanced head and neck cancer treated with cetuximab and radiotherapy. 基础抗体依赖性细胞介导的细胞毒性(ADCC)升高和表皮生长因子受体(EGFR)高表达可预测接受西妥昔单抗和放疗的局部晚期头颈癌患者的预后。
IF 5.8 Q4 Engineering Pub Date : 2017-05-01 Epub Date: 2017-02-14 DOI: 10.1007/s00262-017-1960-8
Laura Lattanzio, Nerina Denaro, Daniela Vivenza, Chiara Varamo, Giuliana Strola, Mirella Fortunato, Emmanuel Chamorey, Alberto Comino, Martino Monteverde, Cristiana Lo Nigro, Gerard Milano, Marco Merlano

Background: Antibody-dependent cell-mediated cytotoxicity (ADCC) may contribute to the antitumor activity of cetuximab. However, the extent of this contribution is unclear. In this study, we investigated the impact of baseline ADCC on the outcome of patients with locally advanced squamous cell carcinoma treated with cetuximab and radiotherapy.

Methods: We determined baseline ADCC in 28 patients treated with cetuximab and radiotherapy and in 15 patients treated with chemoradiation. We linked the values observed with complete response and with overall survival. We also considered the role of epidermal growth factor receptor (EGFR) expression and studied the combined effect of EGFR and ADCC.

Results: We observed a wide range of baseline values of ADCC. Complete response did not correlate with either ADCC or EGFR expression. However, when ADCC and EGFR were considered together using a mixed score, they significantly correlated with achieving a complete response (p = 0.04). High baseline ADCC significantly correlated with outcome compared to low (p = 0.03), but not in patients treated without cetuximab. Patients showing high baseline levels of both ADCC and EGFR3+ achieved the best outcome compared to the others (p = 0.02).

Conclusions: In this study, patients treated with cetuximab and radiotherapy, showing high baseline of both ADCC and EGFR3+, have significant higher probability of achieving a complete response and a long overall survival compared to the others.

背景:抗体依赖性细胞介导的细胞毒性(ADCC)可能有助于西妥昔单抗的抗肿瘤活性。然而,这种贡献的程度尚不清楚。在这项研究中,我们调查了基线 ADCC 对接受西妥昔单抗和放疗的局部晚期鳞状细胞癌患者预后的影响:我们测定了28名接受西妥昔单抗和放疗的患者以及15名接受化疗的患者的基线ADCC。我们将观察到的数值与完全应答和总生存期联系起来。我们还考虑了表皮生长因子受体(EGFR)表达的作用,并研究了EGFR和ADCC的联合效应:我们观察到 ADCC 的基线值范围很广。完全应答与ADCC或表皮生长因子受体表达均无相关性。然而,当使用混合评分法同时考虑 ADCC 和表皮生长因子受体时,它们与获得完全应答显著相关(p = 0.04)。高基线ADCC与低基线ADCC相比与疗效有明显相关性(p = 0.03),但在未使用西妥昔单抗治疗的患者中没有相关性。与其他患者相比,ADCC和表皮生长因子受体3+基线水平均较高的患者获得的疗效最好(p = 0.02):在这项研究中,与其他患者相比,接受西妥昔单抗和放疗的患者中,ADCC和表皮生长因子受体3+基线水平较高的患者获得完全应答和较长的总生存期的概率要高得多。
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引用次数: 0
Seismic response control of benchmark highway bridge using passive hybrid control systems 基于被动混合控制系统的基准公路桥梁地震响应控制
Q4 Engineering Pub Date : 2017-01-01 DOI: 10.1504/IJMSI.2017.10010797
Kamalesh Bhowmik, P. Saha
In this study, the seismic response of a benchmark highway bridge is investigated with passive hybrid systems consisting of high damping rubber bearing (HDRB) and linear and nonlinear viscous fluid damper (VFD). The Phase I problem of the benchmark highway bridge is considered for this study. The ground acceleration is applied at all supports of the bridge. A comparative study is performed among the passive control strategies for seismic response control of the highway bridge by calculating various evaluation criteria as mentioned in the benchmark highway bridge problem. A parametric study has been conducted to find different parameters of VFD and HDRB. The optimum damping coefficient and velocity exponent are found for VFD and optimum isolation time period and optimum damping ratio are found for HDRB. The passive hybrid control system consisting of HDRB and nonlinear VFD gives better performance for reduction of base shear, overturning moment, displacement at midspan, bearing deformation and displacement at abutment of the bridge. Hence, it can be deduced that the performance of passive hybrid control system consisting of HDRB and nonlinear VFD is better than individual VFD and HDRB control systems.
采用由高阻尼橡胶支座(HDRB)和线性及非线性粘性流体阻尼器(VFD)组成的被动混合动力系统,对某基准公路桥梁的地震响应进行了研究。本研究考虑的是基准公路桥一期问题。地面加速度作用于桥梁的所有支撑点。通过计算基准公路桥梁问题中的各种评价标准,对公路桥梁地震反应控制的被动控制策略进行了对比研究。对VFD和HDRB的不同参数进行了参数化研究。找到了VFD的最佳阻尼系数和速度指数,HDRB的最佳隔振时间和最佳阻尼比。由HDRB和非线性VFD组成的被动混合控制系统对降低桥梁的基底剪力、倾覆力矩、跨中位移、支座变形和桥台位移具有较好的效果。由此可以推断,由HDRB和非线性VFD组成的被动混合控制系统的性能优于单独的VFD和HDRB控制系统。
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引用次数: 4
Predicting structural properties of amorphous silicon carbonitride by atomistic simulation 原子模拟预测非晶碳氮化硅的结构特性
Q4 Engineering Pub Date : 2016-10-10 DOI: 10.1504/IJMSI.2016.079642
N. Liao, Miao Zhang, R. Raj, S. Zhou
Silicon carbonitride (SiCN) has superior mechanical properties at high temperature, but its structural properties in molecular scale are not clear. In this study, atomistic simulations were applied to study the molecular structure of amorphous SiCN. The atomistic structures obtained by large-scale molecular dynamics simulations agree with current experimental results, and moreover, provide more details on molecular structure. The Si-C bonds generally keep stable proportion for all the three cases, which means the additional carbon tends to form free carbon network rather than Si-C bonds. Si-CN3 is dominant inSi-C/N tetrahedron, and as expected the increase of C content in SiCN tends to form more Si-C2N2 and Si-C3N tetrahedra.
碳氮化硅(SiCN)具有优异的高温力学性能,但其在分子尺度上的结构特性尚不清楚。本研究采用原子模拟方法研究了非晶SiCN的分子结构。大尺度分子动力学模拟得到的原子结构与目前的实验结果一致,而且提供了更多的分子结构细节。三种情况下Si-C键的比例基本保持稳定,这意味着附加碳倾向于形成自由碳网络,而不是Si-C键。Si-CN3为主要的si -C/N四面体,随着SiCN中C含量的增加,Si-C2N2和Si-C3N四面体的形成趋于增多。
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引用次数: 0
A review on design of interface structure in micro/nano manufacturing 微纳制造中界面结构设计研究进展
Q4 Engineering Pub Date : 2016-10-10 DOI: 10.1504/IJMSI.2016.079638
Ping Yang, Yunqing Tang, Bing Yang
Interface structure is a critical part of electronic components in computers, smart phones, automotive components and other electronic devices. Along with the development of technologies, the demand for electronic devices and their quality has increased rapidly in recent years. Thus, it is indispensable to research the design and reliability of interface structure. In this article, we give a review of recent investigations on the design and reliability of interface structure. Some academic developments on design and reliability of interface structure by considering thermal characteristics under different loading conditions are discussed.
接口结构是计算机、智能手机、汽车零部件等电子器件中电子元件的重要组成部分。近年来,随着科技的发展,人们对电子设备的需求及其质量迅速提高。因此,对界面结构的设计和可靠性进行研究是必不可少的。本文综述了近年来在界面结构设计和可靠性方面的研究进展。讨论了考虑不同载荷条件下热特性的界面结构设计和可靠性的一些学术进展。
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引用次数: 0
Random fatigue analysis of drill-pipe threaded connection 钻杆螺纹连接随机疲劳分析
Q4 Engineering Pub Date : 2016-10-10 DOI: 10.1504/IJMSI.2016.079646
Jiahao Zheng, Jianming Yang
Threaded connections are widely used in connecting drill pipes into a drill string. During drilling operations, the threaded connections are subjected to various external loads, including the load from the unevenness of rock formation at the bottom, impact from the well bore and axial hook load etc. These loads are primarily random, and will cause fatigue damage to the connections during drilling operation. In this paper, a standard 4.5" API line pipe threaded connection is analysed to investigate the fatigue effect of the random loads. A static stress analysis is first conducted considering 'make-up' and 'tensile load' steps. Then modal analysis and random vibration analysis are carried out, with the excitation considered as random. The fatigue damage is predicted using the so called three-band technique based on the stress results obtained. Effects of parameters, such as the random excitation, location of the connection, and friction coefficient, on the fatigue are discussed.
螺纹连接广泛用于将钻杆连接成钻柱。在钻井作业中,螺纹接头承受各种外部载荷,包括底部岩层的不均匀性载荷、井筒的冲击和轴向挂钩载荷等。这些载荷主要是随机的,在钻井作业中会对连接造成疲劳损伤。本文对一种标准的4.5" API管线螺纹接头进行了分析,研究了随机载荷作用下的疲劳效应。首先进行静态应力分析,考虑“补充”和“拉伸载荷”步骤。然后进行模态分析和随机振动分析,认为激励是随机的。根据得到的应力结果,采用三波段法对疲劳损伤进行预测。讨论了随机激励、连接位置和摩擦系数等参数对疲劳的影响。
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引用次数: 2
A general boundary scan test system based on EDIF netlist file transfer to Protel netlist file 一个基于EDIF网表文件传输到Protel网表文件的通用边界扫描测试系统
Q4 Engineering Pub Date : 2016-10-10 DOI: 10.1504/IJMSI.2016.079641
Shouhong Chen, Zhuang Wang, Hou Xingna, Xuelong Yan, Ping Yang
Boundary scan test technology provides a powerful means to solve the difficult problem of high density integrated test system components. It introduces the development of a more general boundary scan test system based on electronic design interchange format (EDIF) and Protel netlist which can transfer EDIF netlist file to Protel netlist file. According to the characteristics of EDIF netlist file and Protel netlist file, the design and implementation of a compiler to transfer EDIF to Protel netlist file is presented. The compiler uses Flex and Bison to deal with EDIF files for lexical and syntax checking, error handling, and then according to the rules of Protel it generates the Protel netlist file. The test system can achieve the test and fault diagnosis.
边界扫描测试技术为解决高密度集成测试系统组件难题提供了有力手段。介绍了一种基于电子设计交换格式(EDIF)和Protel网表的通用边界扫描测试系统的开发,该系统可以实现EDIF网表文件到Protel网表文件的转换。根据EDIF网表文件和Protel网表文件的特点,设计并实现了一个将EDIF转换为Protel网表文件的编译器。编译器使用Flex和Bison对EDIF文件进行词法和语法检查、错误处理,然后根据Protel的规则生成Protel网表文件。该测试系统可以实现测试和故障诊断。
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引用次数: 2
Research on ship-hull plate's curve forming by means of line heating with variable velocity 变速线加热成形船体板曲线的研究
Q4 Engineering Pub Date : 2016-10-10 DOI: 10.1504/IJMSI.2016.079640
Liang Qi, Tianbo Li, W. Mao, Ping Yang
Line heating (LH) technology is the main process mode in ship-hull plate's curve forming. Generally, operators implement LH process with constant velocity which is easy and convenient to realise. However, phenomenon of 'non-uniform deformation' is easily generated along heating path. The paper studies the root of the phenomenon and puts forth a new kind of LH technology with variable velocity. Internal relationship between temperature field and deformation field under the new technology is studied by numerical simulations. Simulation results show that the new technology can alleviate negative effects of the phenomenon effectively.
线加热技术是船体板曲线成形的主要工艺方式。一般情况下,操作人员采用等速执行LH过程,易于实现。然而,沿加热路径容易产生“不均匀变形”现象。本文研究了这一现象的根源,提出了一种新的变速LH技术。通过数值模拟研究了新工艺下温度场与变形场的内在关系。仿真结果表明,新技术可以有效地缓解该现象的负面影响。
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引用次数: 1
期刊
International Journal of Materials and Structural Integrity
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