Pub Date : 2021-01-01DOI: 10.5336/dermato.2021-82039
G. Akay, Burcu Tuğrul
{"title":"Assessment of the Mean Platelet Volume-to-Platelet Count Ratio in Alopecia Areata: A Retrospective Case Control Study","authors":"G. Akay, Burcu Tuğrul","doi":"10.5336/dermato.2021-82039","DOIUrl":"https://doi.org/10.5336/dermato.2021-82039","url":null,"abstract":"","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70757657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5336/dermato.2020-78575
Zekiye Kanat, M. Pepele
{"title":"Evaluation of Patients Directed from Emergency Department to Dermatology Clinic","authors":"Zekiye Kanat, M. Pepele","doi":"10.5336/dermato.2020-78575","DOIUrl":"https://doi.org/10.5336/dermato.2020-78575","url":null,"abstract":"","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70756705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5336/dermato.2020-75529
Ayşe Dursun, A. Aktürk, E. Demirsoy
1 Jefa de Residentes del Servicio de Dermatología 2 Jefa del Servicio de Dermatología 3 Profesor Consulto en Dermatología 4 Jefa del Servicio de Anatomía Patológica Hospital Nacional Profesor Alejandro Posadas, El Palomar, Provincia de Buenos Aires, Argentina Contacto del Autor: María Lertora E-mail: marialertorael@gmail.com Fecha de trabajo recibido: 26/10/2020 Fecha de trabajo aceptado: 18/3/2021 Conflicto de interés: los autores declaran que no existe conflicto de interés.
{"title":"Trigeminal Trophic Syndrome","authors":"Ayşe Dursun, A. Aktürk, E. Demirsoy","doi":"10.5336/dermato.2020-75529","DOIUrl":"https://doi.org/10.5336/dermato.2020-75529","url":null,"abstract":"1 Jefa de Residentes del Servicio de Dermatología 2 Jefa del Servicio de Dermatología 3 Profesor Consulto en Dermatología 4 Jefa del Servicio de Anatomía Patológica Hospital Nacional Profesor Alejandro Posadas, El Palomar, Provincia de Buenos Aires, Argentina Contacto del Autor: María Lertora E-mail: marialertorael@gmail.com Fecha de trabajo recibido: 26/10/2020 Fecha de trabajo aceptado: 18/3/2021 Conflicto de interés: los autores declaran que no existe conflicto de interés.","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70756744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2020-74503
Damla Demir, Ezgi Aktaş Karabay, I. Altunay, F. Y. Ozturk
ABS TRACT Objective: A strong link between psoriasis and obesity, type 2 diabetes, insulin resistance dyslipidaemia and metabolic syndrome has been documented. The aim of this study was to investigate the effects of methotrexate (MTX), a conventional antipsoriatic agent, and tumour necrosis factor (TNF)-alpha inhibitors (TNFi) on insulin resistance in pa- tients with psoriasis. Material and Methods: Thirty-one patients with psoriasis treated with MTX and TNFi were prospectively evaluated. Se- venteen patients received MTX, while 14 received the TNFi treatment. At the baseline and at week 12 values of serum C-reactive protein (CRP), the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and lipid parameters were evaluated. Results: The decrease in CRP le- vels after the treatment was significantly higher in the TNFi group than in the MTX group (-1.76 vs. -0.1, p = 0.005; respectively). The levels of serum glucose showed increases in both therapy groups, which was statistically significant in only TNFi group (p = 0.012). Although it was not statistically significant, increases in the HOMA-IR values were noted in MTX and TNFi therapy groups (0.26 ± 1.77 vs. 0.59±1.81, p = 0.558, p = 249; respectively). Conclusion: In the present study, a significant increase in the levels of fasting serum glucose was observed in TNFi group, and an increase in HOMA-IR values was noted in both therapy groups, which is not consistent with the literature. Despite the short follow-up pe- riod and small sample size, we believe that the effects of the TNFi and MTX demand caution for the follow-up of psoriasis, which is already an insulin-resistant condition.
目的:牛皮癣与肥胖、2型糖尿病、胰岛素抵抗、血脂异常和代谢综合征之间存在密切联系。本研究的目的是探讨甲氨蝶呤(MTX)，一种传统的抗银屑病药物，和肿瘤坏死因子(TNF)- α抑制剂(TNFi)对银屑病患者胰岛素抵抗的影响。材料与方法:对31例经MTX联合TNFi治疗的银屑病患者进行前瞻性评价。17例患者接受MTX治疗，14例接受TNFi治疗。在基线和第12周的血清c反应蛋白(CRP)值，胰岛素抵抗稳态模型评估(HOMA-IR)和脂质参数进行评估。结果:TNFi组治疗后CRP水平下降明显高于MTX组(-1.76 vs -0.1, p = 0.005;分别)。两组患者血清葡萄糖水平均升高，仅TNFi组有统计学意义(p = 0.012)。虽然没有统计学意义，但MTX和TNFi治疗组HOMA-IR值升高(0.26±1.77比0.59±1.81,p = 0.558, p = 249;分别)。结论:本研究中，TNFi组空腹血糖水平明显升高，两组HOMA-IR值均升高，但与文献不一致。尽管随访时间短，样本量小，但我们认为TNFi和MTX的效果需要谨慎对待牛皮癣的随访，牛皮癣已经是一种胰岛素抵抗性疾病。
{"title":"Impact of Treatment with Methotrexate and TNF Alpha Inhibitors on Insulin Resistance in Patients with Psoriasis","authors":"Damla Demir, Ezgi Aktaş Karabay, I. Altunay, F. Y. Ozturk","doi":"10.5336/dermato.2020-74503","DOIUrl":"https://doi.org/10.5336/dermato.2020-74503","url":null,"abstract":"ABS TRACT Objective: A strong link between psoriasis and obesity, type 2 diabetes, insulin resistance dyslipidaemia and metabolic syndrome has been documented. The aim of this study was to investigate the effects of methotrexate (MTX), a conventional antipsoriatic agent, and tumour necrosis factor (TNF)-alpha inhibitors (TNFi) on insulin resistance in pa- tients with psoriasis. Material and Methods: Thirty-one patients with psoriasis treated with MTX and TNFi were prospectively evaluated. Se- venteen patients received MTX, while 14 received the TNFi treatment. At the baseline and at week 12 values of serum C-reactive protein (CRP), the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and lipid parameters were evaluated. Results: The decrease in CRP le- vels after the treatment was significantly higher in the TNFi group than in the MTX group (-1.76 vs. -0.1, p = 0.005; respectively). The levels of serum glucose showed increases in both therapy groups, which was statistically significant in only TNFi group (p = 0.012). Although it was not statistically significant, increases in the HOMA-IR values were noted in MTX and TNFi therapy groups (0.26 ± 1.77 vs. 0.59±1.81, p = 0.558, p = 249; respectively). Conclusion: In the present study, a significant increase in the levels of fasting serum glucose was observed in TNFi group, and an increase in HOMA-IR values was noted in both therapy groups, which is not consistent with the literature. Despite the short follow-up pe- riod and small sample size, we believe that the effects of the TNFi and MTX demand caution for the follow-up of psoriasis, which is already an insulin-resistant condition.","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70756247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2019-71783
O. Kutlu, I. Balta, H. Ekşioğlu
6 Acne vulgaris (AV) is a chronic, inflammatory disease of the pilosebaceous unit and may affect all age groups, although it usually occurs in adolescents. Four major factors in the pathogenesis of acne include increased sebum production, abnormal follicular keratinization, Propionibacterium acnes (P. acnes) proliferation and inflammation.1,2 Pilosebaceous unit activity is controlled by androgen hormones. Obesity is currently a major health problem and is frequently associated with peripheral hyperandrogenism. Since carbohydrate-rich Western type diet has become widespread especially in recent years and the patients with AV are often on this diet, diet factor is considered likely to be one of the factors that trigger the disDetermination of the Effect of Diet on the Development and Severity of Acne Vulgaris by Using Insulin Index and Glycemic Index
{"title":"Determination of the Effect of Diet on the Development and Severity of Acne Vulgaris by Using Insulin Index and Glycemic Index","authors":"O. Kutlu, I. Balta, H. Ekşioğlu","doi":"10.5336/dermato.2019-71783","DOIUrl":"https://doi.org/10.5336/dermato.2019-71783","url":null,"abstract":"6 Acne vulgaris (AV) is a chronic, inflammatory disease of the pilosebaceous unit and may affect all age groups, although it usually occurs in adolescents. Four major factors in the pathogenesis of acne include increased sebum production, abnormal follicular keratinization, Propionibacterium acnes (P. acnes) proliferation and inflammation.1,2 Pilosebaceous unit activity is controlled by androgen hormones. Obesity is currently a major health problem and is frequently associated with peripheral hyperandrogenism. Since carbohydrate-rich Western type diet has become widespread especially in recent years and the patients with AV are often on this diet, diet factor is considered likely to be one of the factors that trigger the disDetermination of the Effect of Diet on the Development and Severity of Acne Vulgaris by Using Insulin Index and Glycemic Index","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"30 1","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70755004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2019-71481
Seda Pürnak, S. Çakmak, B. Çakır, T. Turhan, F. Artüz
functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation.1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut.2 MK has critical function in development and repair mechanisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells.3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels.5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5
{"title":"Serum Midkine Levels in Patients with Psoriasis","authors":"Seda Pürnak, S. Çakmak, B. Çakır, T. Turhan, F. Artüz","doi":"10.5336/dermato.2019-71481","DOIUrl":"https://doi.org/10.5336/dermato.2019-71481","url":null,"abstract":"functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation.1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut.2 MK has critical function in development and repair mechanisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells.3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels.5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"30 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70755295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2019-65508
B. Erdem, M. Gönül, D. Ateş, Ö. Gököz, M. Albayrak, I. Akdag
30 miloidozis, primer ya da çeşitli hastalıklara sekonder olarak anormal protein yapısındaki amiloid denilen maddenin dokularda ve organlarda birikimi ile karakterize bir hastalıktır.1 Amiloid ana bileşeni fibril proteinden oluşur, diğer bileşenler amiloid p bileşeni, glikozaminoglikanlar ve apoE lipoproteindir.2 Hastalığın patogenezinde, birtakım protein ve protein öncülerinin yanlış katlanması sonucu çözünmez amiloid hâline gelerek hücre dışı dokularda birikmesi yatmaktadır.3 Sistemik ve loDeri Bulgularıyla Tanı Konulan Multipl Miyelomla İlişkili Bir Sistemik Amiloidoz Olgusu
30 miloidosis是一种称为淀粉样蛋白的物质的特征，在第一次或第二次发作中形成异常蛋白，在其中一个器官中，淀粉样蛋白由主要的复合原纤维蛋白、其他化合物淀粉样蛋白、葡糖氨基聚糖和apoE脂蛋白组成，birtakım蛋白ve蛋白öncülerinin yanlışkatlanmasısonucuçözünmez amiloid hâline gelerek hücre dış
{"title":"A Case of Systemic Amyloidosis Associated with Multiple Myeloma Diagnosed with Skin Findings","authors":"B. Erdem, M. Gönül, D. Ateş, Ö. Gököz, M. Albayrak, I. Akdag","doi":"10.5336/dermato.2019-65508","DOIUrl":"https://doi.org/10.5336/dermato.2019-65508","url":null,"abstract":"30 miloidozis, primer ya da çeşitli hastalıklara sekonder olarak anormal protein yapısındaki amiloid denilen maddenin dokularda ve organlarda birikimi ile karakterize bir hastalıktır.1 Amiloid ana bileşeni fibril proteinden oluşur, diğer bileşenler amiloid p bileşeni, glikozaminoglikanlar ve apoE lipoproteindir.2 Hastalığın patogenezinde, birtakım protein ve protein öncülerinin yanlış katlanması sonucu çözünmez amiloid hâline gelerek hücre dışı dokularda birikmesi yatmaktadır.3 Sistemik ve loDeri Bulgularıyla Tanı Konulan Multipl Miyelomla İlişkili Bir Sistemik Amiloidoz Olgusu","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70753990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2019-65980
Ü. Öner, Handan Bilen, Hatice Gencer, M. Melikoğlu, Şevki Özdemir
{"title":"A Case of Phyto Contact Dermatitis Due to Mentha pulegium","authors":"Ü. Öner, Handan Bilen, Hatice Gencer, M. Melikoğlu, Şevki Özdemir","doi":"10.5336/dermato.2019-65980","DOIUrl":"https://doi.org/10.5336/dermato.2019-65980","url":null,"abstract":"","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70754184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5336/dermato.2019-72771
E. P. Yüksel
For other rare primary cu- taneous T cell lymphomas, differential diagnosis is made with clinical, histopathological and immunophenotyping features. Primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type are 3 types of primary cutaneous B-cell lymphomas. Staging is important for the follow up, prognosis and treatment of the patients with primary cu- taneous lymphomas. Staging of mycosis fungoides and Sezary syndrome is based on TNMB classification. Clinical features and surface area of the lesions are important for the evaluation of the skin. Exci-sional biopsy is recommended for examination of abnormal lymph nodes. Prognosis regarding lymph nodes is related to effaced nodal ar-chitecture. TNM classification is used for staging other primary cuta- neous lymphomas and central lymph nodes are also evaluated.
{"title":"Diagnosis and Staging in Primary Cutaneous Lymphomas","authors":"E. P. Yüksel","doi":"10.5336/dermato.2019-72771","DOIUrl":"https://doi.org/10.5336/dermato.2019-72771","url":null,"abstract":"For other rare primary cu- taneous T cell lymphomas, differential diagnosis is made with clinical, histopathological and immunophenotyping features. Primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type are 3 types of primary cutaneous B-cell lymphomas. Staging is important for the follow up, prognosis and treatment of the patients with primary cu- taneous lymphomas. Staging of mycosis fungoides and Sezary syndrome is based on TNMB classification. Clinical features and surface area of the lesions are important for the evaluation of the skin. Exci-sional biopsy is recommended for examination of abnormal lymph nodes. Prognosis regarding lymph nodes is related to effaced nodal ar-chitecture. TNM classification is used for staging other primary cuta- neous lymphomas and central lymph nodes are also evaluated.","PeriodicalId":39132,"journal":{"name":"Turkiye Klinikleri Dermatoloji","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70755557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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