Background: Prostatic adenocarcinoma is the second leading cause of death in males due to cancer. The prostate-specific antigen (PSA) serum level is the first marker for screening such patients. Objectives: The present study evaluated the comparison between the degree of staining of the PSA marker and some factors in the prognosis of prostate cancer. Methods: The current cross-sectional study was performed on 97 tissue blocks from patients with prostate adenocarcinoma collected in 2019-2020 from the Pathology Department of Golestan Ahvaz Hospital archives. Clinical information such as age, tumor size, grade of tumor, lymph node involvement, and vascular and perineural invasion was extracted from patients' pathology reports and recorded on a checklist. Then, PSA apical and intensity staining was studied using immunohistochemistry. Results: The mean age of patients was 72.76 ± 8.19 years. The mean serum PSA level was 39.2 ± 8.90. In the present study, the highest PSA staining intensity in the samples was related to grade 1 with a frequency of 39 (40.2%), and then it was related to grade 4 with a frequency of 38 (39.2%), while the lowest frequency of staining intensity was related to grade 2 was with a frequency of 9 (9.3%). Regarding PSA apical staining, 58 samples (59.8%) were positive, and 39 (40.2%) were negative. A statistically significant comparison was shown between Gleason scoring and PSA apical staining (P < 0.001). The results indicate that increasing Gleason scoring decreases the staining intensity, and this correlation is significant (P < 0.05). The mean age in samples with positive staining of apical marker PSA is lower than in samples with negative staining of apical marker PSA but is not statistically significant (P = 0.38). In contrast, the serum level of the PSA marker is statistically significantly higher in samples with positive staining of apical marker PSA than in samples with negative staining of PSA (P < 0.001). According to the Spearman correlation coefficient test, the intensity of staining of the PSA marker decreases with age, and this correlation is significant (P = 0.032). However, according to the Spearman correlation coefficient test, staining intensity increases with increasing serum PSA level, and this correlation is statistically significant (P < 0.001). Conclusions: It is also suggested that in future studies with a larger sample size, the comparison between apical marker expression and PSA marker staining intensity with clinicopathological factors, survival and mortality rates, response to treatment, etc., will be evaluated.
{"title":"Diagnostic and Prognostic Role of Prostate-Specific Antigen Immunologic Staining in Prostate Cancer","authors":"","doi":"10.5812/semj-127269","DOIUrl":"https://doi.org/10.5812/semj-127269","url":null,"abstract":"Background: Prostatic adenocarcinoma is the second leading cause of death in males due to cancer. The prostate-specific antigen (PSA) serum level is the first marker for screening such patients. Objectives: The present study evaluated the comparison between the degree of staining of the PSA marker and some factors in the prognosis of prostate cancer. Methods: The current cross-sectional study was performed on 97 tissue blocks from patients with prostate adenocarcinoma collected in 2019-2020 from the Pathology Department of Golestan Ahvaz Hospital archives. Clinical information such as age, tumor size, grade of tumor, lymph node involvement, and vascular and perineural invasion was extracted from patients' pathology reports and recorded on a checklist. Then, PSA apical and intensity staining was studied using immunohistochemistry. Results: The mean age of patients was 72.76 ± 8.19 years. The mean serum PSA level was 39.2 ± 8.90. In the present study, the highest PSA staining intensity in the samples was related to grade 1 with a frequency of 39 (40.2%), and then it was related to grade 4 with a frequency of 38 (39.2%), while the lowest frequency of staining intensity was related to grade 2 was with a frequency of 9 (9.3%). Regarding PSA apical staining, 58 samples (59.8%) were positive, and 39 (40.2%) were negative. A statistically significant comparison was shown between Gleason scoring and PSA apical staining (P < 0.001). The results indicate that increasing Gleason scoring decreases the staining intensity, and this correlation is significant (P < 0.05). The mean age in samples with positive staining of apical marker PSA is lower than in samples with negative staining of apical marker PSA but is not statistically significant (P = 0.38). In contrast, the serum level of the PSA marker is statistically significantly higher in samples with positive staining of apical marker PSA than in samples with negative staining of PSA (P < 0.001). According to the Spearman correlation coefficient test, the intensity of staining of the PSA marker decreases with age, and this correlation is significant (P = 0.032). However, according to the Spearman correlation coefficient test, staining intensity increases with increasing serum PSA level, and this correlation is statistically significant (P < 0.001). Conclusions: It is also suggested that in future studies with a larger sample size, the comparison between apical marker expression and PSA marker staining intensity with clinicopathological factors, survival and mortality rates, response to treatment, etc., will be evaluated.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86791984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Obsessive-compulsive disorder is identified by intrusive thoughts and related compulsive behaviors. Memory complaints are controversial among obsessive-compulsive disorder patients. Objectives: The present study compared verbal, visual, episodic, and semantic memory between obsessive-compulsive disorder patients and healthy controls. Methods: This is a case-control study. The participants included 31 newly diagnosed obsessive-compulsive disorder outpatients and 30 healthy controls. The patients were selected using targeted sampling from Emam Reza Polyclinic, affiliated with blinded for peer review. They responded to a demographic checklist, structured clinical interview for DSM-IV (SCID-I), verbal and visual episodic memory from the Wechsler Memory Scale-Revised (WMS-R), and autobiographical memory interview (AMI). Results: The results indicated that patients with obsessive-compulsive disorder compared with the controls had lower scores in visual (P = 0.0001), verbal (P = 0.006), semantic (P = 0.3), and episodic memory (P = 0.001). Conclusions: All types of memory which were evaluated in the present study were impaired in obsessive-compulsive disorder. Memory impairment might explain the psychiatric symptoms of the disorder.
{"title":"Episodic Memory in Obsessive-Compulsive Disorder: Comparison with Healthy Controls","authors":"","doi":"10.5812/semj-115654","DOIUrl":"https://doi.org/10.5812/semj-115654","url":null,"abstract":"Background: Obsessive-compulsive disorder is identified by intrusive thoughts and related compulsive behaviors. Memory complaints are controversial among obsessive-compulsive disorder patients. Objectives: The present study compared verbal, visual, episodic, and semantic memory between obsessive-compulsive disorder patients and healthy controls. Methods: This is a case-control study. The participants included 31 newly diagnosed obsessive-compulsive disorder outpatients and 30 healthy controls. The patients were selected using targeted sampling from Emam Reza Polyclinic, affiliated with blinded for peer review. They responded to a demographic checklist, structured clinical interview for DSM-IV (SCID-I), verbal and visual episodic memory from the Wechsler Memory Scale-Revised (WMS-R), and autobiographical memory interview (AMI). Results: The results indicated that patients with obsessive-compulsive disorder compared with the controls had lower scores in visual (P = 0.0001), verbal (P = 0.006), semantic (P = 0.3), and episodic memory (P = 0.001). Conclusions: All types of memory which were evaluated in the present study were impaired in obsessive-compulsive disorder. Memory impairment might explain the psychiatric symptoms of the disorder.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86465117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Haemophilia is one of the hereditary recessive diseases linked to sex-induced coagulation disorder and is characterized by bleeding episodes. This report presents a rare involvement of the distal phalanx hemophilic pseudotumor. Case Presentation: A 21-year-old man was crushed by a closing door 18 months before. The distal phalanx was fractured, and a large hematoma developed under the nail plate, which separated the nail plate from its bed. Eighteen months after the injury, plain radiographs demonstrated an expansile lesion with extensive destruction of the distal phalanx. Regarding the patient’s history and abnormal clotting tests, the development of a hemophilic pseudotumor was considered at the distal phalanx due to the enlarging nature of the coagulum, which induced compression and pressure necrosis on the adjacent bone and structures. Conclusions: Hemophilic pseudotumors in the small bones are rarely reported. After a minor traumatic injury in hand, exact management and coagulopathy control are important to prevent further complications.
{"title":"Hemophilic Pseudotumor of the Distal Phalanx","authors":"A. Afshar, A. Tabrizi","doi":"10.5812/semj-132255","DOIUrl":"https://doi.org/10.5812/semj-132255","url":null,"abstract":"Introduction: Haemophilia is one of the hereditary recessive diseases linked to sex-induced coagulation disorder and is characterized by bleeding episodes. This report presents a rare involvement of the distal phalanx hemophilic pseudotumor. Case Presentation: A 21-year-old man was crushed by a closing door 18 months before. The distal phalanx was fractured, and a large hematoma developed under the nail plate, which separated the nail plate from its bed. Eighteen months after the injury, plain radiographs demonstrated an expansile lesion with extensive destruction of the distal phalanx. Regarding the patient’s history and abnormal clotting tests, the development of a hemophilic pseudotumor was considered at the distal phalanx due to the enlarging nature of the coagulum, which induced compression and pressure necrosis on the adjacent bone and structures. Conclusions: Hemophilic pseudotumors in the small bones are rarely reported. After a minor traumatic injury in hand, exact management and coagulopathy control are important to prevent further complications.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82421403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Promoting the immunity of pregnant women during the Covid-19 pandemic through vaccination against SARS-CoV-2 infection is one of the main challenges. It is important to manage the information related to receiving the vaccine and its possible complications for surveillance of its safety and to deal with the challenges. Based on this, it is necessary to design a national information management system for the COVID-19 vaccination. Objectives: To promote the safety of pregnant women by providing a national model of an information management system for pregnant women's COVID-19 vaccination in Iran. Methods: The present research was of applied descriptive type. Based on the review of articles and information sources and a comparative study of the information management and surveillance system for the vaccination of pregnant women in developed countries, and according to the country's organizational structure, the national model of the information management system for pregnant women's COVID-19 vaccination was designed for Iran. Then the validation of the model was examined in two steps using the Delphi technique. Finally, after analyzing the data, the final model was presented. Results: The findings were categorized into two main groups, including the structural components (responsible organization and databases, surveillance center, participating organizations, and data sources) and informational process (data set, data collection, quality control, data exchanges, data processing, reporting) that reached 100% consensus of experts. Conclusions: For developing IMS for the COVID-19 vaccination of pregnant women, it is necessary to specify the responsible organization and the participating centers, create surveillance centers and databases, and define the information management system process.
{"title":"Promoting the Safety of Pregnant Women: Information Management System Strategy for the COVID-19 Vaccination","authors":"F. Asadi, Roya Shakiba, R. Rabiei, H. Emami","doi":"10.5812/semj-135224","DOIUrl":"https://doi.org/10.5812/semj-135224","url":null,"abstract":"Background: Promoting the immunity of pregnant women during the Covid-19 pandemic through vaccination against SARS-CoV-2 infection is one of the main challenges. It is important to manage the information related to receiving the vaccine and its possible complications for surveillance of its safety and to deal with the challenges. Based on this, it is necessary to design a national information management system for the COVID-19 vaccination. Objectives: To promote the safety of pregnant women by providing a national model of an information management system for pregnant women's COVID-19 vaccination in Iran. Methods: The present research was of applied descriptive type. Based on the review of articles and information sources and a comparative study of the information management and surveillance system for the vaccination of pregnant women in developed countries, and according to the country's organizational structure, the national model of the information management system for pregnant women's COVID-19 vaccination was designed for Iran. Then the validation of the model was examined in two steps using the Delphi technique. Finally, after analyzing the data, the final model was presented. Results: The findings were categorized into two main groups, including the structural components (responsible organization and databases, surveillance center, participating organizations, and data sources) and informational process (data set, data collection, quality control, data exchanges, data processing, reporting) that reached 100% consensus of experts. Conclusions: For developing IMS for the COVID-19 vaccination of pregnant women, it is necessary to specify the responsible organization and the participating centers, create surveillance centers and databases, and define the information management system process.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77103954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Honarvar, E. Khaksar, P. Keshavarz, M. Banakar, Abbas Balaghi Inalou, Yasman Movahednejad, Vahid Hajianpour
Background: Quality of life (QOL) in the elderly has not been investigated as much as their life expectancy. Objectives: The present study aimed to evaluate the elders’ QOL. Methods: In this study, 386 elders were selected using the multistage cluster random sampling method. The Leiden-Padua (LIEPAD) questionnaire, consisting of the core components (CCQOL) and moderators (MQOL) of QOL, was used and analyzed with SPSS software. Results: The interviewees’ mean age was 68.12 ± 6.24 years. The QOL score was 83.67 ± 13.75 (out of 127), consisting of 27 (6.9%) elders with low, 316 (81.8%) elders with moderate, and 43 (11%) elders with high levels of QOL. The CCQOL and MQOL scores were 70.68 ± 9.42 (out of 93), and 20.94 ± 2.30 (out of 34), respectively. According to the multivariate analysis, sleep disorders (B = -0.15), osteoporosis (B = -0.14), female gender (B = -0.13), and not being the source of family income (B = -0.13) were inversely correlated with QOL. In contrast, sleep disorders, facing violence, female gender, migraine, psychological diseases, and not being the source of family income were inversely correlated with CCQOL. Sexual problems, facing violence, no supplementary insurance coverage, inability to walk, and migraine had inverse correlations with MQOL. Conclusions: Seven out of ten elders had a moderate level of QOL, while elderly females and elders with chronic diseases or those who were not the source of family income had lower levels of QOL. Accordingly, the elders’ QOL can be improved by integrating the elders’ care programs in the health centers.
{"title":"Quality of Life in Elderlies: A Cross-Sectional and Field-Based Study in Iran","authors":"B. Honarvar, E. Khaksar, P. Keshavarz, M. Banakar, Abbas Balaghi Inalou, Yasman Movahednejad, Vahid Hajianpour","doi":"10.5812/semj-130534","DOIUrl":"https://doi.org/10.5812/semj-130534","url":null,"abstract":"Background: Quality of life (QOL) in the elderly has not been investigated as much as their life expectancy. Objectives: The present study aimed to evaluate the elders’ QOL. Methods: In this study, 386 elders were selected using the multistage cluster random sampling method. The Leiden-Padua (LIEPAD) questionnaire, consisting of the core components (CCQOL) and moderators (MQOL) of QOL, was used and analyzed with SPSS software. Results: The interviewees’ mean age was 68.12 ± 6.24 years. The QOL score was 83.67 ± 13.75 (out of 127), consisting of 27 (6.9%) elders with low, 316 (81.8%) elders with moderate, and 43 (11%) elders with high levels of QOL. The CCQOL and MQOL scores were 70.68 ± 9.42 (out of 93), and 20.94 ± 2.30 (out of 34), respectively. According to the multivariate analysis, sleep disorders (B = -0.15), osteoporosis (B = -0.14), female gender (B = -0.13), and not being the source of family income (B = -0.13) were inversely correlated with QOL. In contrast, sleep disorders, facing violence, female gender, migraine, psychological diseases, and not being the source of family income were inversely correlated with CCQOL. Sexual problems, facing violence, no supplementary insurance coverage, inability to walk, and migraine had inverse correlations with MQOL. Conclusions: Seven out of ten elders had a moderate level of QOL, while elderly females and elders with chronic diseases or those who were not the source of family income had lower levels of QOL. Accordingly, the elders’ QOL can be improved by integrating the elders’ care programs in the health centers.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76235816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identifying Organizations Providing Healthcare Services in Floods and Explaining Their Duties to Children","authors":"A. Dehghani, K. Jahangiri","doi":"10.5812/semj-130143","DOIUrl":"https://doi.org/10.5812/semj-130143","url":null,"abstract":"<jats:p />","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73145823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) are demonstrated to promote the repair of mandibular defects. Objectives: This study investigated the mechanical properties and calcium content at the tooth extraction site in a rat model exposed to LLLT (λ = 808 nm) with or without PRP. Methods: In this experimental rat model study, the left first molar maxillary teeth were extracted in twenty male rats. Then, the animals were randomly divided into four groups. Group one: after extraction, the extraction sockets were treated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours for the next 12 days (4 times overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was applied; group four: the extraction sockets remained untreated (the control group). All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Mann-Whitney test, one-way ANOVA test, and post hoc Fisher’s least significant difference (LSD) were used to analyze the data. A P-value less than 0.05 was considered significant. All analyses were performed by SPSS 16.0. The graph is illustrated in the graph pad 5. Results: The compressive strength in the laser group was significantly higher than in the control and PRP-treated groups (P = 0.0001 and 0.00044, respectively). Compared to the control and PRP groups, the effects of a combination of PRP and LLLT mechanical strength were statistically similar. Calcium content was influenced by none of the treatments. Conclusions: The mechanical strength of the bone blocks was significantly stronger in the LLLT group than in the other groups. PRP alone or combined with LLLT demonstrated a synergistic impact on neither mechanical strength nor calcium content.
{"title":"Evaluating the Effects of Low-level Laser Therapy and Platelet-rich Plasma on Bone Calcium Content and Mechanical Properties at Tooth Extraction Sites: An Animal Study","authors":"Alireza Sharifi, N. Tanideh, Hossein Khaje Zadeh, Meysam Haghighat, Sheila Shahsavari-pour, Saeid Tavanafard","doi":"10.5812/semj-130303","DOIUrl":"https://doi.org/10.5812/semj-130303","url":null,"abstract":"Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) are demonstrated to promote the repair of mandibular defects. Objectives: This study investigated the mechanical properties and calcium content at the tooth extraction site in a rat model exposed to LLLT (λ = 808 nm) with or without PRP. Methods: In this experimental rat model study, the left first molar maxillary teeth were extracted in twenty male rats. Then, the animals were randomly divided into four groups. Group one: after extraction, the extraction sockets were treated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours for the next 12 days (4 times overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was applied; group four: the extraction sockets remained untreated (the control group). All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Mann-Whitney test, one-way ANOVA test, and post hoc Fisher’s least significant difference (LSD) were used to analyze the data. A P-value less than 0.05 was considered significant. All analyses were performed by SPSS 16.0. The graph is illustrated in the graph pad 5. Results: The compressive strength in the laser group was significantly higher than in the control and PRP-treated groups (P = 0.0001 and 0.00044, respectively). Compared to the control and PRP groups, the effects of a combination of PRP and LLLT mechanical strength were statistically similar. Calcium content was influenced by none of the treatments. Conclusions: The mechanical strength of the bone blocks was significantly stronger in the LLLT group than in the other groups. PRP alone or combined with LLLT demonstrated a synergistic impact on neither mechanical strength nor calcium content.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78597983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Bagheri Lankarani, A. Ardekani, Reza Fereidooni, Seyed Reza Abdipour Mehrian, Reza Moshfeghinia, Hafez Shojaaldini, Dorsa Shekouh, Aida Bazrgar, Masoumeh Saberi Rounkian, N. Maharlouei, H. Joulaei, M. Zakeri, S. Heydari, M. Bazargan
{"title":"Women’s Health in Post-COVID Era: A report from the 11th International Conference on Women’s Health","authors":"K. Bagheri Lankarani, A. Ardekani, Reza Fereidooni, Seyed Reza Abdipour Mehrian, Reza Moshfeghinia, Hafez Shojaaldini, Dorsa Shekouh, Aida Bazrgar, Masoumeh Saberi Rounkian, N. Maharlouei, H. Joulaei, M. Zakeri, S. Heydari, M. Bazargan","doi":"10.5812/semj-135187","DOIUrl":"https://doi.org/10.5812/semj-135187","url":null,"abstract":"<jats:p />","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73547963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification the Individual Vulnerability to COVID-19","authors":"Z. Ghaffari, Mahboubeh Es'haghi","doi":"10.5812/semj-118143","DOIUrl":"https://doi.org/10.5812/semj-118143","url":null,"abstract":"<jats:p />","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78980305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Negin Tavakoli Haghighiand, S. Mehrabani, M. E. Esmaeili Dooki, M. Hajiahmadi, L. Moslemi, H. Asgarirad, Ali Farmoudeh, Rogheih Aghalari
Background: One of the most common functional problems in children is functional abdominal pain (FAP), and dysmotility is one of the possible causes of FAP. Domperidone is a prokinetic drug that increases gastrointestinal motility. Objectives: The aim of this study was to evaluate the effect of domperidone on the treatment of FAP in children. Methods: In this double-blind clinical trial study, FAP was diagnosed in 80 children aged 5 - 14 years, who were referred to Amirkola Children's Hospital in Babol for one year based on the criteria of the Rome IV. Then, they were randomly divided into two groups of 40 patients. Group A received domperidone tablets (0.25 mg/kg, three-time/day) for two months, and group B received a placebo. The primary outcome was at least a 50% reduction in both frequency and severity of pain, and the secondary outcome was a significant reduction in the duration, frequency, and intensity of pain according to the Wong-Baker scale compared to baseline. Results: A total of 80 children completed the trial (40 with domperidone). The recovery rate was higher in the domperidone group than in the placebo group after eight weeks (71.8% vs. 28.2%; P < 0.0001), and domperidone had significant superiority over the placebo in reducing the duration (4.58 ± 7.71 vs. 24.5 ± 41.45, min/day, P < 0.001), frequency (3.35 ± 3.99 vs. 10.63 ± 10.55, episode/week, P < 0.001), and intensity (2.20 ± 2.16 vs. 5.05 ± 2.37, P < 0.001) of the pain. Conclusions: Based on the results, domperidone can be useful in the treatment of FAP in children.
背景:儿童最常见的功能问题之一是功能性腹痛(FAP)，而运动障碍是导致FAP的可能原因之一。多潘立酮是一种促进胃肠运动的药物。目的:本研究的目的是评价多潘立酮对儿童FAP的治疗效果。方法:在本双盲临床试验研究中，对80例5 ~ 14岁的儿童诊断为FAP，根据罗马IV标准转诊至巴博勒Amirkola儿童医院1年，然后将其随机分为两组，每组40例。A组给予多潘立酮片(0.25 mg/kg, 3次/天)，疗程2个月，B组给予安慰剂。主要结局是疼痛的频率和严重程度至少减少50%，次要结局是根据Wong-Baker量表，与基线相比，疼痛的持续时间、频率和强度显著减少。结果:共有80名儿童完成了试验(其中40名使用多潘立酮)。8周后，多潘立酮组的恢复率高于安慰剂组(71.8% vs. 28.2%;P < 0.0001)，多潘立酮在减轻疼痛持续时间(4.58±7.71 vs. 24.5±41.45，分钟/天，P < 0.001)、频率(3.35±3.99 vs. 10.63±10.55，发作次数/周，P < 0.001)和强度(2.20±2.16 vs. 5.05±2.37,P < 0.001)方面明显优于安慰剂。结论:基于上述结果，多潘立酮可用于治疗儿童FAP。
{"title":"Effect of Domperidone on Children with Functional Abdominal Pain: A Randomized Controlled Clinical Trial","authors":"Negin Tavakoli Haghighiand, S. Mehrabani, M. E. Esmaeili Dooki, M. Hajiahmadi, L. Moslemi, H. Asgarirad, Ali Farmoudeh, Rogheih Aghalari","doi":"10.5812/semj-128504","DOIUrl":"https://doi.org/10.5812/semj-128504","url":null,"abstract":"Background: One of the most common functional problems in children is functional abdominal pain (FAP), and dysmotility is one of the possible causes of FAP. Domperidone is a prokinetic drug that increases gastrointestinal motility. Objectives: The aim of this study was to evaluate the effect of domperidone on the treatment of FAP in children. Methods: In this double-blind clinical trial study, FAP was diagnosed in 80 children aged 5 - 14 years, who were referred to Amirkola Children's Hospital in Babol for one year based on the criteria of the Rome IV. Then, they were randomly divided into two groups of 40 patients. Group A received domperidone tablets (0.25 mg/kg, three-time/day) for two months, and group B received a placebo. The primary outcome was at least a 50% reduction in both frequency and severity of pain, and the secondary outcome was a significant reduction in the duration, frequency, and intensity of pain according to the Wong-Baker scale compared to baseline. Results: A total of 80 children completed the trial (40 with domperidone). The recovery rate was higher in the domperidone group than in the placebo group after eight weeks (71.8% vs. 28.2%; P < 0.0001), and domperidone had significant superiority over the placebo in reducing the duration (4.58 ± 7.71 vs. 24.5 ± 41.45, min/day, P < 0.001), frequency (3.35 ± 3.99 vs. 10.63 ± 10.55, episode/week, P < 0.001), and intensity (2.20 ± 2.16 vs. 5.05 ± 2.37, P < 0.001) of the pain. Conclusions: Based on the results, domperidone can be useful in the treatment of FAP in children.","PeriodicalId":39157,"journal":{"name":"Shiraz E Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81643388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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