Pub Date : 2025-08-20DOI: 10.1016/j.clinmicnews.2025.08.001
Nada Ouahabi , Abderrazak Saddari , Said Ezrari , Mohammed Lahmer , Safae Ouahabi , Chaimaa Boujloud , Wissam Azizi , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb
Citrobacter koseri is a Gram-negative bacillus of the Enterobacteriaceae family, formerly known as Citrobacter diversus. While this pathogen is known to cause severe infections in neonates, cerebral abscesses due to C. koseri in adults are exceptionally uncommon. We present a rare case of a brain abscess in an elderly man caused by C. koseri, successfully treated with ceftriaxone, resulting in a favorable clinical outcome.
{"title":"Cerebral abscess caused by Citrobacter koseri: A case report and review of the literature","authors":"Nada Ouahabi , Abderrazak Saddari , Said Ezrari , Mohammed Lahmer , Safae Ouahabi , Chaimaa Boujloud , Wissam Azizi , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb","doi":"10.1016/j.clinmicnews.2025.08.001","DOIUrl":"10.1016/j.clinmicnews.2025.08.001","url":null,"abstract":"<div><div>Citrobacter koseri is a Gram-negative bacillus of the Enterobacteriaceae family, formerly known as Citrobacter diversus. While this pathogen is known to cause severe infections in neonates, cerebral abscesses due to C. koseri in adults are exceptionally uncommon. We present a rare case of a brain abscess in an elderly man caused by C. koseri, successfully treated with ceftriaxone, resulting in a favorable clinical outcome.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"53 ","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.1016/j.clinmicnews.2025.08.002
Arijit Pal , Arkaprabha Sau
Lophomonas sp. is a multiflagellated protozoan commonly found in the intestines of cockroaches and is increasingly being recognized as a potential respiratory pathogen. We report an unusual case of a 25-year-old male patient from the Eastern Part of India with chronic rhinitis unresponsive to conventional therapy, in whom Lophomonas sp. was identified in nasal secretions. The patient lived in poor hygienic conditions with a significant cockroach infestation. Microscopic examination of nasal discharge revealed motile, multiflagellated protozoa resembling Lophomonas blattarum. This case highlights the importance of considering rare parasitic infections in individuals with chronic upper respiratory symptoms, particularly those with known environmental exposures.
{"title":"Lophomonas sp. infection in a patient with chronic rhinitis","authors":"Arijit Pal , Arkaprabha Sau","doi":"10.1016/j.clinmicnews.2025.08.002","DOIUrl":"10.1016/j.clinmicnews.2025.08.002","url":null,"abstract":"<div><div><em>Lophomonas</em> sp. is a multiflagellated protozoan commonly found in the intestines of cockroaches and is increasingly being recognized as a potential respiratory pathogen. We report an unusual case of a 25-year-old male patient from the Eastern Part of India with chronic rhinitis unresponsive to conventional therapy, in whom <em>Lophomonas</em> sp. was identified in nasal secretions. The patient lived in poor hygienic conditions with a significant cockroach infestation. Microscopic examination of nasal discharge revealed motile, multiflagellated protozoa resembling <em>Lophomonas blattarum</em>. This case highlights the importance of considering rare parasitic infections in individuals with chronic upper respiratory symptoms, particularly those with known environmental exposures.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 85-87"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-22DOI: 10.1016/j.clinmicnews.2025.05.005
Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny
The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20-30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.
{"title":"Laboratory diagnosis of nontuberculous Mycobacteria – an update – Part 2: Specimen collection and laboratory work-up","authors":"Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny","doi":"10.1016/j.clinmicnews.2025.05.005","DOIUrl":"10.1016/j.clinmicnews.2025.05.005","url":null,"abstract":"<div><div>The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20-30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 62-75"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-25DOI: 10.1016/j.clinmicnews.2025.06.008
Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny
The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20-30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.
{"title":"Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 3*: Molecular diagnostics, environmental testing, and notifiable conditions","authors":"Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny","doi":"10.1016/j.clinmicnews.2025.06.008","DOIUrl":"10.1016/j.clinmicnews.2025.06.008","url":null,"abstract":"<div><div>The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20-30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 50-60"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-18DOI: 10.1016/j.clinmicnews.2025.06.007
Kaoutar Jamal , Said Ezrari , Abderrazak Saddari , Sabah Mokhtari , Zahi Ismaili , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb
Streptococcus gordonii is a commensal bacterium rarely described in human infections. Herein, we describe a case of cholangitis due to Streptococcus gordonii. A 62-year-old woman, known to have had cholelithiasis, with history of gastroesophageal reflux and a brother who died of nasopharyngeal carcinoma, was admitted due to abdominal pain, fever, and jaundice. Abdominal computed tomography showed moderate dilation of the common and intrahepatic bile duct upstream of stones the distal ampullary portion, and cholelithiasis. The patient underwent endoscopic retrograde cholangiopancreatography and intraoperative sampling of bile fluid. The patient received empiric antibiotic therapy based on parenteral ceftriaxone and metronidazole. The microbiological analysis revealed the exclusive presence of Streptococcus gordonii. The initial treatment was maintained for 5 days and then replaced by oral amoxicillin-clavulanate and metronidazole. The clinical evolution was favorable. We present here a case of cholangitis caused by Streptococcus gordonii and a literature review.
{"title":"Cholangitis caused by Streptococcus gordonii: A case report and review of the literature","authors":"Kaoutar Jamal , Said Ezrari , Abderrazak Saddari , Sabah Mokhtari , Zahi Ismaili , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb","doi":"10.1016/j.clinmicnews.2025.06.007","DOIUrl":"10.1016/j.clinmicnews.2025.06.007","url":null,"abstract":"<div><div><em>Streptococcus gordonii</em> is a commensal bacterium rarely described in human infections. Herein, we describe a case of cholangitis due to <em>Streptococcus gordonii</em>. A 62-year-old woman, known to have had cholelithiasis, with history of gastroesophageal reflux and a brother who died of nasopharyngeal carcinoma, was admitted due to abdominal pain, fever, and jaundice. Abdominal computed tomography showed moderate dilation of the common and intrahepatic bile duct upstream of stones the distal ampullary portion, and cholelithiasis. The patient underwent endoscopic retrograde cholangiopancreatography and intraoperative sampling of bile fluid. The patient received empiric antibiotic therapy based on parenteral ceftriaxone and metronidazole. The microbiological analysis revealed the exclusive presence of <em>Streptococcus gordonii</em>. The initial treatment was maintained for 5 days and then replaced by oral amoxicillin-clavulanate and metronidazole. The clinical evolution was favorable. We present here a case of cholangitis caused by <em>Streptococcus gordonii</em> and a literature review.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 24-30"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-17DOI: 10.1016/j.clinmicnews.2025.06.006
Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny
The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20–30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.
{"title":"Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 1★: Epidemiology, environment sources, and guidance for the provider","authors":"Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny","doi":"10.1016/j.clinmicnews.2025.06.006","DOIUrl":"10.1016/j.clinmicnews.2025.06.006","url":null,"abstract":"<div><div>The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20–30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 31-43"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-16DOI: 10.1016/j.clinmicnews.2025.06.005
Parham Salmani , Masoud Keikha , Mohsen Karbalaei
Clostridium botulinum is an anaerobic, spore-forming bacterium which produces eight different antigenic exotoxins (A, B, C1, C2, D, E, F, and G) and among them A, B, E and F are special for humans. This toxin has heavy (H) and light (L) chains, the light chain acts on Snap-25 protein in neuromuscular junction and cause paralysis in skeletal muscles by disabling SNARE proteins and then inhibiting the release of acetylcholine, then, causing diplopia, dysarthria, dysphagia. Among all clinical signs, dysarthria is characterized by difficulty in speech which is caused by paralysis of muscles of larynx, pharynx and oral cavity which are related to phonation and then speech. Dysarthria is a sign of botulism that appears in different kinds of botulism, but especially in wound botulism. Early administration of antitoxin play a vital role in the treatment, but the efficacy of antibiotic therapy has not been completely understood, because it can either improve or worsen the situation, also supportive treatments such as mechanical ventilation, physiotherapy and gastric lavage may help to reduce the incubation period.
{"title":"Clostridium botulinum disorders associated with speech processes and verbal communication: a comprehensive and documented review","authors":"Parham Salmani , Masoud Keikha , Mohsen Karbalaei","doi":"10.1016/j.clinmicnews.2025.06.005","DOIUrl":"10.1016/j.clinmicnews.2025.06.005","url":null,"abstract":"<div><div><em>Clostridium botulinum</em> is an anaerobic, spore-forming bacterium which produces eight different antigenic exotoxins (A, B, C1, C2, D, E, F, and G) and among them A, B, E and F are special for humans. This toxin has heavy (H) and light (L) chains, the light chain acts on Snap-25 protein in neuromuscular junction and cause paralysis in skeletal muscles by disabling SNARE proteins and then inhibiting the release of acetylcholine, then, causing diplopia, dysarthria, dysphagia. Among all clinical signs, dysarthria is characterized by difficulty in speech which is caused by paralysis of muscles of larynx, pharynx and oral cavity which are related to phonation and then speech. Dysarthria is a sign of botulism that appears in different kinds of botulism, but especially in wound botulism. Early administration of antitoxin play a vital role in the treatment, but the efficacy of antibiotic therapy has not been completely understood, because it can either improve or worsen the situation, also supportive treatments such as mechanical ventilation, physiotherapy and gastric lavage may help to reduce the incubation period.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 44-49"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号