Clinical Microbiology Newsletter最新文献_第4页

Morganella morganii: an opportunistic multidrug-resistant pathogen isolated in ascitic fluid in an old man, case report and literature review 莫氏摩根菌：一种从老人腹水中分离出的机会性多重耐药病原菌，病例报告及文献复习

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-04-24 DOI: 10.1016/j.clinmicnews.2025.04.004

Ismail Faiz , Abderrazak Saddari , Said Ezrari , Mohammed Lahmer , Samir Kaddouri , Elmostafa Benaissa , Yassine BenLahlou , Mostafa Elouennass , Adil Maleb

Morganella morganii is commonly found in nature and is also part of the normal intestinal flora in humans and animals. Although typically an opportunistic pathogen, it is rarely isolated in human infections. Infections caused by this bacterium primarily include postoperative wound infections, urinary tract infections, sepsis, abscesses, chorioamnionitis, and cellulitis. The emergence of multidrug-resistant strains poses a significant public health concern, as these strains can lead to severe or even fatal infections in vulnerable patients. We report the case of a 94-year-old immunocompromised patient admitted to the emergency department with dyspnea, significant ascites, and prolonged fever. A C-TAP scan revealed chronic liver disease with large-volume ascites. Laboratory tests showed a mild inflammatory response (CRP: 14 mg/L), low prothrombin time (PT: 56%), hypoalbuminemia (19 g/L), pancytopenia, and macrocytic anemia. Cytobacteriological analysis of the ascitic fluid revealed a significant neutrophilic response and the growth of Morganella morganii. Antibiotic susceptibility testing showed susceptibility to carbapenems, fluoroquinolones, co-trimoxazole, and chloramphenicol, while resistance was observed against penicillins (aminopenicillins, carboxypenicillins, ureidopenicillins), cephalosporins, fosfomycin/trometamol, and aminoglycosides. The multidrug-resistant strain of Morganella morganii in this case demonstrated concerning resistance to most β-lactams, aminoglycosides, and fosfomycin/trometamol. Given its increasingly opportunistic nature, multidrug resistance, and potential to cause severe nosocomial infections, clinicians must consider this bacterium during the diagnostic process.

摩氏摩根菌常见于自然界，也是人类和动物正常肠道菌群的一部分。虽然它通常是一种机会性病原体，但在人类感染中很少分离出来。这种细菌引起的感染主要包括术后伤口感染、尿路感染、败血症、脓肿、绒毛膜羊膜炎和蜂窝织炎。耐多药菌株的出现引起了重大的公共卫生关注，因为这些菌株可导致易感患者发生严重甚至致命的感染。我们报告一个94岁的免疫功能低下的病人入院急诊科呼吸困难，明显腹水，并延长发烧。C-TAP扫描显示慢性肝病伴大量腹水。实验室检查显示轻度炎症反应（CRP: 14 mg/L），凝血酶原时间低（PT: 56%），低白蛋白血症（19 g/L），全血细胞减少症和大细胞性贫血。腹水的细胞细菌学分析显示明显的嗜中性反应和摩根氏摩根菌的生长。抗生素药敏试验显示对碳青霉烯类、氟喹诺酮类、复方新诺明和氯霉素敏感，对青霉素类（氨霉素类、羧霉素类、脲霉素类）、头孢菌素类、磷霉素/曲美醇类和氨基糖苷类耐药。在本病例中，多重耐药菌株莫氏摩根菌对大多数β-内酰胺类、氨基糖苷类和磷霉素/曲霉醇具有耐药性。鉴于其日益增加的机会性、多药耐药性和可能导致严重的医院感染，临床医生在诊断过程中必须考虑这种细菌。

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引用次数: 0

Purulent pericarditis caused by Kytococcus schroeteri: Case report and literature review 鼠形Kytococcus schroeteri致化脓性心包炎1例并文献复习

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-04-21 DOI: 10.1016/j.clinmicnews.2025.04.002

Abir Yahyaoui , Abderrazak Saddari , Said Ezrari , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb

Kytococcus schroeteri is a Gram-positive Cocci, considered a saprophyte of human skin, which can cause severe infections. Diagnosis is difficult due to non-specific clinical manifestations that vary according to the host's immune status and the presence or absence of implantable devices. It appears that this pathogen has the potential to acquire resistance to multiple antibiotic classes, which only exacerbates the challenge of curing it. We report a rare case of K. schroeteri purulent pericarditis in a 40-year-old woman who underwent surgery to implant an implantable catheter chamber in order to receive chemotherapy for her left breast tumor, associated with a pericardial effusion requiring emergency drainage. Microbiological identification by matrix-assisted laser desorption-time-of-flight mass spectrometry (MALDI-TOF MS) demonstrated the exclusive presence of K. schroeteri from the subculture of the aerobic enrichment broth of the pericardial fluid. Prompt initiation of antibiotic therapy adapted to the results of the antimicrobial susceptibility testing led to clinical and biological improvement, marked by normalization of inflammatory indicators. This case sheds light on an emerging microbiological pathogen with the potential to affect a variety of tissues, putting the vital prognosis at risk, and underlines the need for heightened clinical suspicion and an adapted therapeutic approach in immunocompromised patients.

棘球球菌是一种革兰氏阳性球菌，被认为是人体皮肤的腐生菌，可引起严重感染。由于非特异性临床表现根据宿主的免疫状态和有无植入式装置而变化，诊断很困难。这种病原体似乎有可能对多种抗生素产生耐药性，这只会加剧治疗它的挑战。我们报告一例罕见的施氏克雷氏化脓性心包炎病例，该病例发生于一名40岁的女性，她为接受左乳房肿瘤化疗而行手术植入可植入导管腔，并伴有心包积液需要紧急引流。基质辅助激光解吸-飞行时间质谱（MALDI-TOF MS）的微生物鉴定表明，在心包积液的好氧富集培养基的传代培养中，只存在薛氏K. schroeteri。根据抗菌药物敏感性测试结果及时开始抗生素治疗，导致临床和生物学改善，以炎症指标正常化为标志。该病例揭示了一种新出现的微生物病原体，它有可能影响多种组织，使重要的预后处于危险之中，并强调需要加强临床怀疑，并对免疫功能低下的患者采取适应的治疗方法。

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引用次数: 0

Scratching the surface: The rise of antifungal-resistant dermatophytes 触及表面：抗真菌皮肤真菌的兴起

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-04-21 DOI: 10.1016/j.clinmicnews.2025.04.003

Jeremy A.W. Gold, Shawn R. Lockhart

Dermatophytosis (also called ringworm or tinea infection) is a common, contagious superficial infection of the skin, hair, or nails caused by dermatophyte molds. Historically, clinicians have considered dermatophytosis as a mild, easy-to-treat condition; however, the epidemiology of dermatophytosis has changed dramatically in the past decade because of the emergence of dermatophyte strains causing increasingly severe and difficult-to-treat infections. We review three recently emerged dermatophytes of public health concern: Trichophyton indotineae, which is causing outbreaks of frequently terbinafine-resistant and difficult-to-treat tinea in South Asia, with cases also reported across six continents; Trichophyton mentagrophytes genotype VII (TMVII), associated with oral and anogenital tinea infections particularly among men who have sex with men in France and the United States; and terbinafine-resistant Trichophyton rubrum, noted as a cause of difficult-to-treat tinea infections, although data are limited. We discuss practical considerations for identifying these pathogens, which relies on DNA sequencing or MALDI-ToF rather than on morphological characteristics. Additionally, we highlight the importance of antifungal susceptibility testing and practical laboratory considerations. Finally, we emphasize the importance of increased adoption of diagnostic testing for suspected dermatophyte infections, as well as the development of rapid, accurate, and affordable dermatophyte testing methods to help improve diagnostic accuracy and judicious antifungal use. Overall, the emergence of severe and antifungal-resistant dermatophyte infections poses a global public health concern. Clinical microbiologists can play a crucial role in addressing this threat by familiarizing themselves with techniques for identifying emerging dermatophyte species and performing antifungal susceptibility testing to guide patient management, monitor trends, and inform future public health interventions.

皮肤癣（也称为癣或足癣感染）是一种常见的皮肤、头发或指甲的传染性浅表感染，由皮肤癣菌霉菌引起。从历史上看，临床医生认为皮肤癣是一种轻微的，易于治疗的疾病；然而，在过去的十年中，由于皮肤真菌菌株的出现导致越来越严重和难以治疗的感染，皮肤真菌的流行病学发生了巨大的变化。我们回顾了最近出现的三种引起公共卫生关注的皮肤真菌：在南亚经常引起特比萘芬耐药和难以治疗的癣的毛癣菌，六大洲也有病例报告；在法国和美国，与口腔和肛门生殖器癣感染有关的毛癣菌基因型VII (TMVII)，特别是在男男性行为者中；耐特比萘芬的红毛癣菌（Trichophyton rubrum），被认为是难以治疗的癣感染的原因，尽管数据有限。我们讨论了鉴定这些病原体的实际考虑，这些病原体依赖于DNA测序或MALDI-ToF，而不是形态学特征。此外，我们强调抗真菌药敏试验和实际实验室考虑的重要性。最后，我们强调增加对疑似皮肤真菌感染的诊断检测的重要性，以及开发快速、准确和负担得起的皮肤真菌检测方法，以帮助提高诊断准确性和明智地使用抗真菌药物。总的来说，严重和抗真菌耐药的皮肤真菌感染的出现引起了全球公共卫生关注。临床微生物学家可以通过熟悉识别新出现的皮肤真菌种类的技术和进行抗真菌药敏试验来指导患者管理，监测趋势，并为未来的公共卫生干预提供信息，从而在解决这一威胁方面发挥关键作用。

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引用次数: 0

The need for clinical, public health, industry partnerships and collaborations 临床、公共卫生、行业伙伴关系和协作的需要

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-04-14 DOI: 10.1016/j.clinmicnews.2025.04.001

Filipe Cerqueira , Kristen L. Jurcic Smith , Kara J. Levinson , Diana R. Hernández , Andrea M. Prinzi

引用次数: 0

Challenges in the phenotypic detection of streptococcus Pneumoniae from clinical samples in low resource settings 低资源环境下临床样本中肺炎链球菌表型检测的挑战

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-03-20 DOI: 10.1016/j.clinmicnews.2025.03.001

Hafeez Aderinsayo Adekola , Tajudeen Bamidele , Emelda Chukwu , Muinah Fowora , Sola Ajibaye , Abideen Salako , Zaidat Musa , Oliver Ezechi

The phenotypic detection of Streptococcus pneumoniae in clinical samples, particularly those collected from infants, is vital for understanding its epidemiology and improving disease management. However, despite advancements in laboratory techniques, achieving optimal yield of Streptococcus pneumoniae remains a significant challenge. This paper explores the primary obstacles that compromise the effective recovery of Streptococcus pneumoniae from clinical samples and suggests potential strategies for improvement. One of the key issues identified are the effect of various sampling, transportation and storage techniques on the overall bacteria yield. Factors such as improper sample collection methods, inappropriate use or lack of use of transport media, and delays in processing can significantly diminish the viability of Streptococcus pneumoniae. In addition, the choice of culture media and conditions, while critical, may not always support the optimal growth of the bacterium, leading to false-negative results or underestimation of bacterial load. There is a need for a re-evaluation of current protocols, emphasizing the need for standardized procedures that are tailored to the specific requirements of pneumococcal detection. Further research into developing more resilient and specific culture media and better training for healthcare professionals involved in sample collection and processing should be encouraged. Addressing these challenges is crucial for improving diagnostic accuracy, guiding effective treatment strategies, and ultimately reducing the burden of pneumococcal disease.

临床样本中肺炎链球菌的表型检测，特别是那些从婴儿收集的样本，对于了解其流行病学和改善疾病管理至关重要。然而，尽管实验室技术取得了进步，但实现肺炎链球菌的最佳产量仍然是一个重大挑战。本文探讨了从临床样本中有效回收肺炎链球菌的主要障碍，并提出了潜在的改进策略。确定的关键问题之一是各种采样，运输和储存技术对总体细菌产量的影响。样本采集方法不当、运输介质使用不当或使用不足以及处理延误等因素可显著降低肺炎链球菌的生存能力。此外，培养基和条件的选择虽然至关重要，但可能并不总是支持细菌的最佳生长，导致假阴性结果或低估细菌负荷。有必要重新评估目前的方案，强调需要制定适合肺炎球菌检测具体要求的标准化程序。应鼓励进一步研究开发更具弹性和特异性的培养基，并对参与样本收集和处理的保健专业人员进行更好的培训。应对这些挑战对于提高诊断准确性、指导有效的治疗策略以及最终减轻肺炎球菌疾病的负担至关重要。

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引用次数: 0

Chikungunya: The silent threat in the shadows 基孔肯雅热：阴影中的无声威胁

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-02-20 DOI: 10.1016/j.clinmicnews.2025.02.001

Ambreen Talib , Rabbya Rayan Shah , Rameen Atique , Hafiza Arshi Saeed , Ayesha Haidar , Ayesha Nadeem , Areesha Naveed , Javeria Sharif , Ayesha Muazzam , Abdul Samad

Chikungunya virus (CHIKV) is mostly related to arboviruses that cause serious public health threats. CHIKV belongs to the family Togaviridae and genus Alphavirus, the cause of chikungunya fever (CHIKF), an arthritogenic disease. Its distinguishing feature is intense arthralgia that lasts for months and even years in susceptible persons. CHIKF is a re-emerging disease that has occurred as an epidemic in Africa across Asia and America in recent decades and has caused global health threats, leading to outbreaks that impact millions of people. Pathogenesis of CHIKV has been researched for >50 years, but no evidence has led to the development of vaccines or drugs. Current management involves reliving symptoms by supportive care to improve the quality of patients’ lives. The ongoing outbreaks of CHIKV show that there is a crying need to understand the pathogenesis of CHIKV. It is important to comprehend CHKIV to develop prevention and control measures for the spread of the disease. This review aims to provide comprehensive knowledge about CHIKV, shedding light on its host-related factors, vector-related factors, and complicated interactions of viral genetics. By following these complex interactions, this review aims to communicate the studies and research about CHIKV, offering strategies that lead to more effective prevention and control measures for this re-emerging global health threat.

基孔肯雅病毒（CHIKV）主要与引起严重公共卫生威胁的虫媒病毒有关。基孔肯雅热属甲病毒科和甲病毒属，是引起基孔肯雅热（一种关节炎性疾病）的原因。其显著特征是强烈的关节痛，持续数月甚至数年的易感人群。CHIKF是一种重新出现的疾病，近几十年来在非洲、亚洲和美洲流行，造成全球健康威胁，导致影响数百万人的疫情。CHIKV的发病机制已经研究了50年，但没有证据导致疫苗或药物的开发。目前的管理包括通过支持性护理来缓解症状，以改善患者的生活质量。正在发生的CHIKV疫情表明，迫切需要了解CHIKV的发病机制。了解CHKIV对制定预防和控制疾病传播的措施具有重要意义。本文旨在对其宿主相关因素、媒介相关因素以及病毒遗传学的复杂相互作用等方面进行综述。通过跟踪这些复杂的相互作用，本综述旨在传播有关CHIKV的研究和研究，为这一重新出现的全球健康威胁提供更有效的预防和控制措施的战略。

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引用次数: 0

A comparative analysis of Orientia Tsutsugamushi (Scrub Typhus): Essential information on causes, symptoms, and care 恙虫病东方体（恙虫病）的比较分析：病因、症状和护理的基本信息

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-01-16 DOI: 10.1016/j.clinmicnews.2025.01.004

Neetesh Jindal , Kumar Abhishek , Ashish Kumar , Manas Ranjan Dikhit , Roshan Kamal Topno , Krishna Pandey , Ganesh Chandra Sahoo

Scrub typhus is a disease caused by the bacteria Orientia tsutsugamushi, spread primarily by chiggers, which are larval mites. These mites are commonly found in Southeast Asia, including countries like India, Indonesia, and Thailand. The disease is often hard to diagnose because its symptoms—fever, headache, muscle pain, and stomach issues—are similar to other illnesses. A key sign of scrub typhus is an “eschar,” a sore that appears at the bite site. Without treatment, which typically involves antibiotics like doxycycline or azithromycin, the disease can lead to severe complications such as sepsis, shock, and multi-organ failure, with a high mortality rate. Scrub typhus has been documented in various regions, with historical records dating back to the 19th century in China. Despite advances in treatment regimen since World War II, no vaccine is available. Diagnostic methods include serological tests and PCR techniques to detect the bacteria. Preventive measures focus on avoiding areas where chiggers are prevalent and using insect repellent. Even if the scrub typhus fever has been reported from regions such as Japan to northern Australia and the Arabian Peninsula, Indian people from different parts are suffering from this endemic disease and doxycycline has become the drug of choice for the treatment of scrub typhus fever. Clinical diagnosis of scrub typhus and research related to this endemic disease must be assorted as the scrub typhus may become resistant to the current treatment regimen.

恙虫病是一种由恙虫病东方体引起的疾病，主要由恙螨幼虫传播。这些螨虫常见于东南亚，包括印度、印度尼西亚和泰国等国家。这种疾病通常很难诊断，因为它的症状——发烧、头痛、肌肉疼痛和胃病——与其他疾病相似。恙虫病的一个关键症状是“疮疤”，即出现在咬伤部位的疼痛。如果不进行治疗，通常包括多西环素或阿奇霉素等抗生素，这种疾病会导致严重的并发症，如败血症、休克和多器官衰竭，死亡率很高。丛林斑疹伤寒在许多地区都有记载，历史记载可以追溯到19世纪的中国。尽管自第二次世界大战以来治疗方案取得了进展，但没有疫苗可用。诊断方法包括血清学测试和PCR技术来检测细菌。预防措施的重点是避开恙虫流行的地区并使用驱蚊剂。尽管从日本到澳大利亚北部和阿拉伯半岛等地区都报告了丛林斑疹伤寒，但来自不同地区的印度人都患有这种地方病，强力霉素已成为治疗丛林斑疹伤寒的首选药物。恙虫病的临床诊断和相关研究必须结合起来，因为恙虫病可能对目前的治疗方案产生耐药性。

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引用次数: 0

Soft tissue infection with multidrug-resistant Kluyvera ascorbata of extended-spectrum bêta-lactamase type (CTX-M): Case report and literature review 多药耐药克卢维拉抗坏血酸扩展谱bêta-lactamase型（CTX-M）软组织感染1例并文献复习

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-01-15 DOI: 10.1016/j.clinmicnews.2025.01.003

Samir Kaddouri , Abderrazak Saddari , Said Ezrari , Ouahiba Hafhaf , Ismail Faiz , Amjad Idrissi , Omar El Mahi , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb

Kluyvera ascorbata, which belongs to the Enterobacteriaceae family, is a commensal bacterium that is very rarely described in human infections. In this report, we describe a case of soft tissue infection due to Kluyvera ascorbata in a 72-year-old man with comorbidities. He was admitted to the vascular surgery department for the treatment of a gas gangrene of the left foot. The patient received probabilistic antibiotic therapy with metronidazole, ceftriaxone and gentamicin by parenteral route with an amputation of the left leg following critical ischemia of the left lower limb (LLL). Due to the superinfection of the left leg amputation stump, the patient underwent an amputation of the left thigh, followed by multiple debridements of the left thigh amputation stump and drainage of an abscess on the anterior surface of the left thigh in the operating room. A sample of superficial pus was collected intraoperatively for microbiological examination to identify the pathogen and guide therapeutic adjustments. This examination revealed the exclusive presence of Kluyvera ascorbata. The isolate was resistant to the majority of β-lactams, aminoglycosides and sulfonamides. However, it was susceptible at standard dosage to carbapenems, fluoroquinolones, chloramphenicol, fosfomycin-trometamol and nitrofurantoin. The antibiogram highlighted the potential for multi-resistance type ESBL (extended spectrum B-lactamases) which characterizes this bacterium. In addition, Kluyvera spp. have an innate antibiotic resistance mechanism, and it is now accepted that CTX-M are derived from chromosomal beta lactamases of species of the genus Kluyvera. They are part of the extended spectrum β-lactamases (ESBL). Given the above, the treatment regimen has been adapted according to the results of the antibiogram. The patient received parenteral antibiotic therapy with levofloxacin, and the clinical evolution was favorable. This leads us to discuss the pathogenicity of this germ and its multi-resistant potential.

Kluyvera ascorbata属于肠杆菌科，是一种很少在人类感染中描述的共生细菌。在本报告中，我们描述了一例因抗坏血酸克鲁维拉引起的软组织感染，患者为72岁男性，并伴有合并症。他被送进血管外科治疗左脚气性坏疽。患者接受甲硝唑、头孢曲松和庆大霉素的概率抗生素治疗，左下肢严重缺血（LLL）后截肢左腿。由于左腿截肢残端重复感染，患者行左大腿截肢手术，随后在手术室对左大腿截肢残端进行多次清创，并对左大腿前表面脓肿进行引流。术中采集浅表脓液样本进行微生物学检查，以确定病原体并指导治疗调整。这一检查表明，只有克鲁维拉·阿斯科巴塔存在。该菌株对绝大多数β-内酰胺类、氨基糖苷类和磺胺类耐药。在标准剂量下对碳青霉烯类、氟喹诺酮类、氯霉素、磷霉素-曲美醇和呋喃妥英敏感。抗生素谱强调了该细菌具有多耐药型ESBL（扩展谱b -内酰胺酶）的潜力。此外，Kluyvera spp.具有先天的抗生素耐药机制，目前认为CTX-M来源于Kluyvera属物种的染色体β内酰胺酶。它们是扩展谱β-内酰胺酶（ESBL）的一部分。鉴于上述情况，治疗方案已根据抗生素谱的结果进行调整。患者接受左氧氟沙星肠外抗生素治疗，临床进展良好。这导致我们讨论这种细菌的致病性和它的多重抗性潜力。

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引用次数: 0

Phage therapy to treat unresponsive infections: A primer for the clinical microbiology laboratory staff 噬菌体治疗无反应性感染：临床微生物实验室工作人员的入门读物

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-01-15 DOI: 10.1016/j.clinmicnews.2025.01.002

Josephine M. Davey-Young , Dinuri D. Punchihewa , Bernadette Ng , Jenna Wong , Greg J. German

With the increase in antimicrobial resistance and subsequent need for alternatives to traditional antibiotics, phage therapy (PT) has gained a renewed interest. Much like antibiotics, bacteriophages or simply phages, have shown promise in eradicating bacterial infections; however, their fundamental differences require specific laboratory protocols and practices. As bacterial-specific viruses, they must be detected, replicated, and purified for safety and efficacy. The narrow spectrum of activity of phages provides a targeted approach to infection but also necessitates expansive libraries and susceptibility testing to match phages to bacteria. Such testing is not standardized, complicating both research and clinical efforts. This review then provides a background on PT in the clinical microbiology laboratory and an overview of such protocols and practices specific to PT, such as classic susceptibility testing methods and updated approaches. Also covered are the challenges and future directions for the field, as well as resources for clinical and research laboratory personnel.

随着抗菌素耐药性的增加以及随后对传统抗生素替代品的需求，噬菌体疗法（PT）重新引起了人们的兴趣。就像抗生素一样，噬菌体或简称噬菌体，在根除细菌感染方面显示出了希望；然而，它们的根本区别需要特定的实验室协议和实践。作为细菌特异性病毒，它们必须被检测、复制和纯化，以确保安全性和有效性。噬菌体的窄谱活性提供了一种有针对性的感染方法，但也需要广泛的文库和药敏试验来匹配噬菌体和细菌。这种检测没有标准化，使研究和临床工作都变得复杂。这篇综述随后提供了临床微生物实验室PT的背景，并概述了PT的具体方案和实践，如经典的药敏试验方法和最新的方法。也涵盖了该领域的挑战和未来方向，以及临床和研究实验室人员的资源。

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引用次数: 0

Maximizing the diagnostic potential of 1,3 beta-D-glucan assays for invasive fungal infections 最大化1,3 β - d -葡聚糖检测对侵袭性真菌感染的诊断潜力

Q3 Medicine

Clinical Microbiology Newsletter

Pub Date : 2025-01-10 DOI: 10.1016/j.clinmicnews.2025.01.001

Sejal Morjaria , N. Esther Babady

Invasive fungal infections (IFIs) pose a serious threat to patients, particularly those who are immunocompromised. Timely and accurate diagnosis of IFIs is critical to improving outcomes, and conventional diagnostic methods often fall short. The 1,3 Beta-D-Glucan (BDG) assay has become a significant test in the early diagnosis and management of IFIs when used in the appropriate clinical context.

侵袭性真菌感染（IFIs）对患者构成严重威胁，特别是那些免疫功能低下的患者。国际金融机构的及时和准确诊断对于改善结果至关重要，而传统的诊断方法往往达不到要求。在适当的临床环境下，1,3 β - d -葡聚糖（BDG）测定已成为ifi早期诊断和管理的重要测试。

引用次数: 0