Pub Date : 2025-06-16DOI: 10.1016/j.clinmicnews.2025.06.004
Geneviève Amaral , Christopher F. Lowe , Gordon Ritchie , Conor Broderick , Michael Payne , Aleksandra Stefanovic , Nancy Matic , Nick P.G. Gauthier , Samuel D. Chorlton , Patrick Tang , Marc G. Romney
Vibrio cholerae is a motile, gram-negative bacterium typically found in brackish, coastal waters and most often associated with gastroenteritis. This case details a rare presentation of non-O1/O139 V. cholerae cystitis in an immunocompetent 27-year-old male with no urogenital tract abnormalities following exposure to geothermal hot springs in California. We present the diagnostic considerations and challenges in clinical management for this case, and the relevance of climate change for understanding epidemiology and exposure risk relevant to clinical practice.
{"title":"Vibrio cholerae cystitis following geothermal hot springs exposure in California","authors":"Geneviève Amaral , Christopher F. Lowe , Gordon Ritchie , Conor Broderick , Michael Payne , Aleksandra Stefanovic , Nancy Matic , Nick P.G. Gauthier , Samuel D. Chorlton , Patrick Tang , Marc G. Romney","doi":"10.1016/j.clinmicnews.2025.06.004","DOIUrl":"10.1016/j.clinmicnews.2025.06.004","url":null,"abstract":"<div><div><em>Vibrio cholerae</em> is a motile, gram-negative bacterium typically found in brackish, coastal waters and most often associated with gastroenteritis. This case details a rare presentation of non-O1/O139 <em>V. cholerae</em> cystitis in an immunocompetent 27-year-old male with no urogenital tract abnormalities following exposure to geothermal hot springs in California. We present the diagnostic considerations and challenges in clinical management for this case, and the relevance of climate change for understanding epidemiology and exposure risk relevant to clinical practice.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 17-20"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-10DOI: 10.1016/j.clinmicnews.2025.06.002
Kevin Fonseca
Measles, a highly infectious virus, previously eliminated from the Americas in 2000, has returned causing large outbreaks in the USA and Canada, largely in communities with low vaccination rates. Pregnant women, unvaccinated young children and the immunocompromised have the highest risk for severe complications, that include pneumonia, encephalitis and infrequently, death. As there is no treatment, management for the more frequent complications of dehydration and pneumonia require significant acute-care resources with airborne containment during the infectious phase. The current measles vaccine is safe and the only means available to maintain high levels of herd immunity to prevent transmission, until the goal of global elimination of measles is finally achieved.
{"title":"Microbe snapshots: Measles virus","authors":"Kevin Fonseca","doi":"10.1016/j.clinmicnews.2025.06.002","DOIUrl":"10.1016/j.clinmicnews.2025.06.002","url":null,"abstract":"<div><div>Measles, a highly infectious virus, previously eliminated from the Americas in 2000, has returned causing large outbreaks in the USA and Canada, largely in communities with low vaccination rates. Pregnant women, unvaccinated young children and the immunocompromised have the highest risk for severe complications, that include pneumonia, encephalitis and infrequently, death. As there is no treatment, management for the more frequent complications of dehydration and pneumonia require significant acute-care resources with airborne containment during the infectious phase. The current measles vaccine is safe and the only means available to maintain high levels of herd immunity to prevent transmission, until the goal of global elimination of measles is finally achieved.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 14-16"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trueperella pyogenes is a well-known pathogen that causes opportunistic infections in farm animals, especially cattle and pigs. However, human infections are extremely rare and typically linked to occupational exposure. In this report, we present a case of sepsis due to T. pyogenes in an immunocompromised patient. A 75-year-old male patient, with a background of chronic obstructive pulmonary disease and a history of livestock farming, was admitted with headache, nasal congestion, dyspnea, and hypotension. He was hypoxic, pancytopenic, and severely hyponatremic, with elevated inflammatory markers. A biopsy from a maxillary sinus mass revealed nasal-type NK/T-cell lymphoma. Two sets of blood cultures (each consisting of two aerobic and one anaerobic bottle) were collected from separate venipuncture sites 24 h apart. A growth signal was detected on day two, and T. pyogenes was isolated from all bottles across both sets. Beta-hemolytic colonies grew on sheep blood agar; Gram staining revealed pleomorphic Gram-positive rods. The isolate was catalase and oxidase negative and identified as T. pyogenes via VITEK-MS. Susceptibility testing showed resistance to trimethoprim-sulfamethoxazole and susceptibility to penicillin, tetracycline, clindamycin, rifampin, linezolid, and vancomycin. Empirical treatment with meropenem, vancomycin, and levofloxacin was initiated; dexamethasone was added due to suspected lymphoma infiltration. By the fifth day, respiratory symptoms and fever had resolved, and inflammatory markers normalized. The patient was discharged with oral methylprednisolone for lymphoma and levofloxacin for antimicrobial therapy. This case highlights the importance of recognizing T. pyogenes as a rare but significant human pathogen, especially in immunocompromised individuals with animal exposure, and underlines the need for advanced identification methods in clinical microbiology.
{"title":"Trueperella pyogenes bacteremia in a patient with nasal NK/T-cell lymphoma: A case report","authors":"Sinem Özdemir , Okan Aydoğan , Umut Yılmaz , Ahmet Emre Eşkazan , Fatma Köksal Çakırlar","doi":"10.1016/j.clinmicnews.2025.06.001","DOIUrl":"10.1016/j.clinmicnews.2025.06.001","url":null,"abstract":"<div><div><em>Trueperella pyogenes</em> is a well-known pathogen that causes opportunistic infections in farm animals, especially cattle and pigs. However, human infections are extremely rare and typically linked to occupational exposure. In this report, we present a case of sepsis due to <em>T. pyogenes</em> in an immunocompromised patient. A 75-year-old male patient, with a background of chronic obstructive pulmonary disease and a history of livestock farming, was admitted with headache, nasal congestion, dyspnea, and hypotension. He was hypoxic, pancytopenic, and severely hyponatremic, with elevated inflammatory markers. A biopsy from a maxillary sinus mass revealed nasal-type NK/T-cell lymphoma. Two sets of blood cultures (each consisting of two aerobic and one anaerobic bottle) were collected from separate venipuncture sites 24 h apart. A growth signal was detected on day two, and <em>T. pyogenes</em> was isolated from all bottles across both sets. Beta-hemolytic colonies grew on sheep blood agar; Gram staining revealed pleomorphic Gram-positive rods. The isolate was catalase and oxidase negative and identified as <em>T. pyogenes</em> via VITEK-MS. Susceptibility testing showed resistance to trimethoprim-sulfamethoxazole and susceptibility to penicillin, tetracycline, clindamycin, rifampin, linezolid, and vancomycin. Empirical treatment with meropenem, vancomycin, and levofloxacin was initiated; dexamethasone was added due to suspected lymphoma infiltration. By the fifth day, respiratory symptoms and fever had resolved, and inflammatory markers normalized. The patient was discharged with oral methylprednisolone for lymphoma and levofloxacin for antimicrobial therapy. This case highlights the importance of recognizing <em>T. pyogenes</em> as a rare but significant human pathogen, especially in immunocompromised individuals with animal exposure, and underlines the need for advanced identification methods in clinical microbiology.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 10-13"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-26DOI: 10.1016/j.clinmicnews.2025.05.003
Dínimo Bolivar-Saénz , Nohora Patricia Bonilla Solano , Georgina González Tarazona , José Antonio Villamizar Silva , Yohana Alfonso Guerra , Juan Camilo Arango Brand , Andrea Torres Contreras
Objective
Intestinal tuberculosis (ITB) represents an atypical clinical manifestation of tuberculosis, constituting a significant proportion of extrapulmonary cases. This study, combining a case report and a narrative literature review, aims to deepen the understanding of ITB and its clinical characteristics.
Case presentation
We present a clinical case of a young patient with concomitant pulmonary tuberculosis and chronic gastrointestinal symptoms. Imaging studies revealed intestinal wall thickening in the ileum and cecum, findings corroborated by colonoscopy, which showed multiple ulcers and an inflammatory response on biopsy, albeit without direct identification of the bacillus. The patient responded favorably to standard anti-tuberculosis treatment.
Discussion
Our findings, coupled with the literature review, suggest that ITB can present with nonspecific clinical features, hindering early diagnosis. Coexistence with pulmonary tuberculosis is common, and complications such as intestinal obstruction may necessitate surgical intervention.
Conclusion
Intestinal tuberculosis poses a diagnostic challenge due to the variability of its clinical manifestations and the lack of specific diagnostic tests. A high index of clinical suspicion, particularly in patients with pulmonary tuberculosis or risk factors, is crucial for early diagnosis, appropriate management, and consequently enhance the prognosis of the disease.
{"title":"Intestinal tuberculosis diagnosed by clinical presentation, imaging, and endoscopy, associated with pulmonary tuberculosis: A case report and narrative literature review","authors":"Dínimo Bolivar-Saénz , Nohora Patricia Bonilla Solano , Georgina González Tarazona , José Antonio Villamizar Silva , Yohana Alfonso Guerra , Juan Camilo Arango Brand , Andrea Torres Contreras","doi":"10.1016/j.clinmicnews.2025.05.003","DOIUrl":"10.1016/j.clinmicnews.2025.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>Intestinal tuberculosis (ITB) represents an atypical clinical manifestation of tuberculosis, constituting a significant proportion of extrapulmonary cases. This study, combining a case report and a narrative literature review, aims to deepen the understanding of ITB and its clinical characteristics.</div></div><div><h3>Case presentation</h3><div>We present a clinical case of a young patient with concomitant pulmonary tuberculosis and chronic gastrointestinal symptoms. Imaging studies revealed intestinal wall thickening in the ileum and cecum, findings corroborated by colonoscopy, which showed multiple ulcers and an inflammatory response on biopsy, albeit without direct identification of the bacillus. The patient responded favorably to standard anti-tuberculosis treatment.</div></div><div><h3>Discussion</h3><div>Our findings, coupled with the literature review, suggest that ITB can present with nonspecific clinical features, hindering early diagnosis. Coexistence with pulmonary tuberculosis is common, and complications such as intestinal obstruction may necessitate surgical intervention.</div></div><div><h3>Conclusion</h3><div>Intestinal tuberculosis poses a diagnostic challenge due to the variability of its clinical manifestations and the lack of specific diagnostic tests. A high index of clinical suspicion, particularly in patients with pulmonary tuberculosis or risk factors, is crucial for early diagnosis, appropriate management, and consequently enhance the prognosis of the disease.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 4-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clostridioides (Clostridium) difficile produces glutamate dehydrogenase (GDH) in large amounts, which is frequently used to screen C. difficile infection (CDI). Generally, the sensitivity of GDH–enzyme immunoassay (GDH–EIA) is significantly higher than that of the toxin EIA. In this report, we describe an extremely rare case of discrepancy in EIA with GDH-negative and toxin-positive results. Nucleic acid amplification revealed toxin B gene, binary toxin gene, and tcdC deletion. Additionally, the growth of C. difficile was monitored by culture method, which showed positive result for GDH. These findings indicate that laboratory diagnosis of CDI is challenging. Therefore, the results should be carefully interpreted considering the patient’s clinical course.
{"title":"Rare discrepancy in the result of enzyme immunoassay in a patient infected by Clostridioides difficile","authors":"Tatsuya Hioki , Hiroyuki Takenaka , Takumi Umemura , Yoshimi Ishihara , Masayoshi Ajioka , Yoshikazu Mutoh","doi":"10.1016/j.clinmicnews.2025.05.004","DOIUrl":"10.1016/j.clinmicnews.2025.05.004","url":null,"abstract":"<div><div><em>Clostridioides</em> (<em>Clostridium</em>) <em>difficile</em> produces glutamate dehydrogenase (GDH) in large amounts, which is frequently used to screen <em>C. difficile</em> infection (CDI). Generally, the sensitivity of GDH–enzyme immunoassay (GDH–EIA) is significantly higher than that of the toxin EIA. In this report, we describe an extremely rare case of discrepancy in EIA with GDH-negative and toxin-positive results. Nucleic acid amplification revealed toxin B gene, binary toxin gene, and <em>tcdC</em> deletion. Additionally, the growth of <em>C. difficile</em> was monitored by culture method, which showed positive result for GDH. These findings indicate that laboratory diagnosis of CDI is challenging. Therefore, the results should be carefully interpreted considering the patient’s clinical course.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-14DOI: 10.1016/j.clinmicnews.2025.05.001
Antonio Vitiello , Andrea Silenzi , Andrea Zovi , Rosario Sorrentino
The COVID-19 pandemic has caused significant health, social, and economic challenges, with an estimated 65 million people affected by long-term complications collectively referred to as long COVID-19. Symptoms include psychiatric, neurological, cardiovascular, immune, and metabolic disorders, including chronic fatigue syndrome and autoimmune conditions. Risk factors include female sex, lack of vaccination, pre-existing comorbidities, and smoking. A longer duration or increased severity of symptoms is associated with reduced quality of life, physical performance, and the ability to work or attend school. Diagnostic and therapeutic innovations are being adopted, including digital medicine and artificial intelligence. Recovery from long COVID varies widely among individuals, and probiotics have been proposed as effective remedies for fatigue, memory loss, and gastrointestinal symptoms. Further research and data are needed to fully understand the complexity and multi-organ nature of the disease.
{"title":"Long-term complications of SARS-CoV-2 infection (Long COVID)","authors":"Antonio Vitiello , Andrea Silenzi , Andrea Zovi , Rosario Sorrentino","doi":"10.1016/j.clinmicnews.2025.05.001","DOIUrl":"10.1016/j.clinmicnews.2025.05.001","url":null,"abstract":"<div><div>The COVID-19 pandemic has caused significant health, social, and economic challenges, with an estimated 65 million people affected by long-term complications collectively referred to as long COVID-19. Symptoms include psychiatric, neurological, cardiovascular, immune, and metabolic disorders, including chronic fatigue syndrome and autoimmune conditions. Risk factors include female sex, lack of vaccination, pre-existing comorbidities, and smoking. A longer duration or increased severity of symptoms is associated with reduced quality of life, physical performance, and the ability to work or attend school. Diagnostic and therapeutic innovations are being adopted, including digital medicine and artificial intelligence. Recovery from long COVID varies widely among individuals, and probiotics have been proposed as effective remedies for fatigue, memory loss, and gastrointestinal symptoms. Further research and data are needed to fully understand the complexity and multi-organ nature of the disease.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"51 ","pages":"Pages 52-54"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-06DOI: 10.1016/j.clinmicnews.2025.04.006
Sara Soomro , Ramlla Hatif , Muzeer Ahmed , Ayesha Saleem , Muhammad Ateeb Sheikh , Sara Ismail , Abdul Nafey Kazi , Muhammad Junaid Patel
Mortality from Salmonella Typhi fever is very high among South-Asian countries including Pakistan. With the emergence of the extensively drug-resistant Salmonella Typhi strain, mortality has increased among all age groups. Salmonella Typhi usually presents with abdominal symptoms and complications; however, literature has reported its extreme rare clinical presentation with neurological symptoms. We report a case of a young male whose initial presentation was altered mentation and seizures and later diagnosed as having extremely drug-resistant Salmonella Typhi encephalopathy.
{"title":"Extensively drug-resistant Salmonella Typhi encephalopathy: A rare clinical presentation","authors":"Sara Soomro , Ramlla Hatif , Muzeer Ahmed , Ayesha Saleem , Muhammad Ateeb Sheikh , Sara Ismail , Abdul Nafey Kazi , Muhammad Junaid Patel","doi":"10.1016/j.clinmicnews.2025.04.006","DOIUrl":"10.1016/j.clinmicnews.2025.04.006","url":null,"abstract":"<div><div>Mortality from <em>Salmonella Typhi</em> fever is very high among <strong>South-Asian</strong> countries including Pakistan. With the emergence of the extensively drug-resistant <em>Salmonella Typhi</em> strain, mortality has increased among all age groups. <em>Salmonella Typhi</em> usually presents with abdominal symptoms and complications; however, literature has reported its extreme rare clinical presentation with neurological symptoms. We report a case of a young male whose initial presentation was altered mentation and seizures and later diagnosed as having extremely drug-resistant <em>Salmonella Typhi</em> encephalopathy.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"51 ","pages":"Pages 48-51"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-25DOI: 10.1016/j.clinmicnews.2025.04.005
Abdessamad Amrani , Abderrazak Saddari , Said Ezrari , Mohammed Lahmer , Amjad Idrissi , Yasser Akil , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb
Comamonas kerstersii is a non-fermentative Gram-negative bacterium recently described, and its role in serious human infections has been recognized since 2013. In this article, we report the case of a 53-year-old male admitted to the emergency room for acute abdominal pain in the right iliac fossa. Laboratory tests revealed an inflammatory syndrome with CRP at 399.02 mg/L and Procalcitonin at 5.21 ng/mL. An urgent abdominal computed tomography (CT) scan was realized, revealing appendiceal peritonitis. The patient underwent an appendectomy and fluid aspiration. The microbiological analysis of the peritoneal fluid led to the identification of Comamonas kerstersii by MALDI-TOF mass spectrometry. The recent discovery of C. kerstersii and the limits of classical phenotypic methods in its detection are probably leading to an underestimated prevalence. More recently, acquired resistance in this bacterium has been reported, requiring systematic susceptibility testing and the rapid adaptation of therapeutic strategies to improve patient outcomes.
{"title":"Unusual cause of appendiceal peritonitis: Comamonas kerstersii– A case report and literature review","authors":"Abdessamad Amrani , Abderrazak Saddari , Said Ezrari , Mohammed Lahmer , Amjad Idrissi , Yasser Akil , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb","doi":"10.1016/j.clinmicnews.2025.04.005","DOIUrl":"10.1016/j.clinmicnews.2025.04.005","url":null,"abstract":"<div><div><em>Comamonas kerstersii</em> is a non-fermentative Gram-negative bacterium recently described, and its role in serious human infections has been recognized since 2013. In this article, we report the case of a 53-year-old male admitted to the emergency room for acute abdominal pain in the right iliac fossa. Laboratory tests revealed an inflammatory syndrome with CRP at 399.02 mg/L and Procalcitonin at 5.21 ng/mL. An urgent abdominal computed tomography (CT) scan was realized, revealing appendiceal peritonitis. The patient underwent an appendectomy and fluid aspiration. The microbiological analysis of the peritoneal fluid led to the identification of <em>Comamonas kerstersii</em> by MALDI-TOF mass spectrometry. The recent discovery of <em>C. kerstersii</em> and the limits of classical phenotypic methods in its detection are probably leading to an underestimated prevalence. More recently, acquired resistance in this bacterium has been reported, requiring systematic susceptibility testing and the rapid adaptation of therapeutic strategies to improve patient outcomes.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"51 ","pages":"Pages 42-47"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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