{"title":"Enchanted by science: my study of the endothelial cell","authors":"Masaaki Sato","doi":"10.17106/JBR.28.5","DOIUrl":"https://doi.org/10.17106/JBR.28.5","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"24 1","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In those days, I was totally engaged in clinical practice as a cardiologist at the Hokkaido University Hospital. Ten years had passed since my graduation from medical school, and I had begun thinking about leaving the university hospital and finding a new place of work at a community hospital. One morning, Prof. Hisakazu Yasuda made me an unexpected offer. He told me that his friend Prof. Akira Kamiya, Hokkaido University Research Institute of Applied Electricity (currently Research Institute for Electronic Science), had developed a new system for measurement of arteriosclerosis and was on the lookout for a physician who would help him apply this system clinically. Prof. Yasuda asked me if I might be interested in this position. He recommended it to me, saying that experience in basic research for one year or so would expand my perspective field and benefit me. So I accepted this sudden offer that came my way. At that time, I had no idea how this decision would profoundly influence my future life direction.
{"title":"My biorheology research guided by curiosity","authors":"J. Ando","doi":"10.17106/JBR.28.2","DOIUrl":"https://doi.org/10.17106/JBR.28.2","url":null,"abstract":"In those days, I was totally engaged in clinical practice as a cardiologist at the Hokkaido University Hospital. Ten years had passed since my graduation from medical school, and I had begun thinking about leaving the university hospital and finding a new place of work at a community hospital. One morning, Prof. Hisakazu Yasuda made me an unexpected offer. He told me that his friend Prof. Akira Kamiya, Hokkaido University Research Institute of Applied Electricity (currently Research Institute for Electronic Science), had developed a new system for measurement of arteriosclerosis and was on the lookout for a physician who would help him apply this system clinically. Prof. Yasuda asked me if I might be interested in this position. He recommended it to me, saying that experience in basic research for one year or so would expand my perspective field and benefit me. So I accepted this sudden offer that came my way. At that time, I had no idea how this decision would profoundly influence my future life direction.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"28 1","pages":"2-4"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68195272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As is well-known, the mechanical properties of surimi gels are improved by incubation at moderate temperatures (low temperature setting: LTS) prior to high temperature treatment (high temperature setting: HTS). In this study we investigated the effect of the setting temperature on the mechanical properties of surimi gels. To this end, the temporal development of the dynamic modulus during the setting process was investigated at various temperatures. The dynamic modulus of the surimi paste increased with time at low temperature treatment (5 and 10°C). However, this trend reversed at higher temperatures (25 and 30°C). The mechanical properties of the thermal gel, which was heated to 90°C after LTS, were also investigated. In this case, the sample treated at 10°C prior to HTS showed the most rigid property. The protein extracted from both the set surimi paste and thermal gel was analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE). This analysis revealed a relatively high actin content in the thermal gel set at 10°C. Two important findings emerged from the study; the setting temperature at which the gel acquires its most desirable textural properties is not the commercial setting temperature, and actin appears to play an unexpected role in the gelling mechanism.
{"title":"Effect of setting temperature on the mechanical properties of surimi gels","authors":"I. Kaneda, Kohei Aonuma, Y. Funatsu, S. Matsukawa","doi":"10.17106/JBR.28.11","DOIUrl":"https://doi.org/10.17106/JBR.28.11","url":null,"abstract":"As is well-known, the mechanical properties of surimi gels are improved by incubation at moderate temperatures (low temperature setting: LTS) prior to high temperature treatment (high temperature setting: HTS). In this study we investigated the effect of the setting temperature on the mechanical properties of surimi gels. To this end, the temporal development of the dynamic modulus during the setting process was investigated at various temperatures. The dynamic modulus of the surimi paste increased with time at low temperature treatment (5 and 10°C). However, this trend reversed at higher temperatures (25 and 30°C). The mechanical properties of the thermal gel, which was heated to 90°C after LTS, were also investigated. In this case, the sample treated at 10°C prior to HTS showed the most rigid property. The protein extracted from both the set surimi paste and thermal gel was analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE). This analysis revealed a relatively high actin content in the thermal gel set at 10°C. Two important findings emerged from the study; the setting temperature at which the gel acquires its most desirable textural properties is not the commercial setting temperature, and actin appears to play an unexpected role in the gelling mechanism.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"28 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68194845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eijiro Maeda, M. Sugimoto, Youtaro Kosato, C. T. Poon, B. Pingguan-Murphy, T. Ohashi
The present study examined expressions of type I collagen and MMP-1 mRNA of bovine tenocytes in response to elevation in intracellular tension/traction forces induced by either mechanical or chemical stimulation. Tenocytes were cultured in the following conditions: micropillars with the Young’s modulus of 75 kPa in a normal culture medium, in the presence of 1 nM calyculin A in the medium or under 4 or 8% static tensile strain in the normal medium. In all the treatments, cell traction forces were increased significantly from the levels of corresponding control tenocytes. However, these increases in traction forces were not associated with statistically significant increase in type I collagen gene expression. Because our treatments induced the increase in traction forces equidirectionally, it is speculated that highly directional increase in traction forces, associated with an elongated cell shape, is required to induce marked upregulation of type I collagen mRNA expression in tenocytes.
{"title":"Tenocyte anabolic and catabolic response to elevation in intracellular tension","authors":"Eijiro Maeda, M. Sugimoto, Youtaro Kosato, C. T. Poon, B. Pingguan-Murphy, T. Ohashi","doi":"10.17106/JBR.28.16","DOIUrl":"https://doi.org/10.17106/JBR.28.16","url":null,"abstract":"The present study examined expressions of type I collagen and MMP-1 mRNA of bovine tenocytes in response to elevation in intracellular tension/traction forces induced by either mechanical or chemical stimulation. Tenocytes were cultured in the following conditions: micropillars with the Young’s modulus of 75 kPa in a normal culture medium, in the presence of 1 nM calyculin A in the medium or under 4 or 8% static tensile strain in the normal medium. In all the treatments, cell traction forces were increased significantly from the levels of corresponding control tenocytes. However, these increases in traction forces were not associated with statistically significant increase in type I collagen gene expression. Because our treatments induced the increase in traction forces equidirectionally, it is speculated that highly directional increase in traction forces, associated with an elongated cell shape, is required to induce marked upregulation of type I collagen mRNA expression in tenocytes.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"28 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68194922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study is concerned with the flow of blood in an artery with an overlapping mild stenosis. To account for the slip at stenotic wall, hematocrit, pulsatility of flow and inclination of the tube, blood has been represented by a fluid whose viscosity varies with radial coordinate and hematocrit. The expression for the flow characteristics, namely, the wall shear stress, the shear stress at the critical height of the stenosis, the pressure drop and the resistance to flow (impedance) have been derived and represented graphically with respect to different flow parameters. The resistance to flow increases with the hematocrit and critical height of the stenosis but decreases with slip at wall. With respect to any parameter, the shear stress at the critical height possesses the characteristics similar to that of the impedance.
{"title":"Effect of slip on pulsatile flow of blood in a tube with an overlapping mild stenosis","authors":"U. Chakraborty","doi":"10.17106/JBR.28.21","DOIUrl":"https://doi.org/10.17106/JBR.28.21","url":null,"abstract":"The present study is concerned with the flow of blood in an artery with an overlapping mild stenosis. To account for the slip at stenotic wall, hematocrit, pulsatility of flow and inclination of the tube, blood has been represented by a fluid whose viscosity varies with radial coordinate and hematocrit. The expression for the flow characteristics, namely, the wall shear stress, the shear stress at the critical height of the stenosis, the pressure drop and the resistance to flow (impedance) have been derived and represented graphically with respect to different flow parameters. The resistance to flow increases with the hematocrit and critical height of the stenosis but decreases with slip at wall. With respect to any parameter, the shear stress at the critical height possesses the characteristics similar to that of the impedance.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"28 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68195414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulation of binary dispersion system of droplets with size and surface tension difference under Couette flow","authors":"M. Makino, M. Sugihara-Seki","doi":"10.17106/JBR.28.7","DOIUrl":"https://doi.org/10.17106/JBR.28.7","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"28 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.28.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68195371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-01DOI: 10.1007/S12573-012-0053-8
K. Bando, K. Ohba, Y. Oiso
{"title":"Deformation analysis of microcapsules compressed by two rigid parallel plates","authors":"K. Bando, K. Ohba, Y. Oiso","doi":"10.1007/S12573-012-0053-8","DOIUrl":"https://doi.org/10.1007/S12573-012-0053-8","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"27 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S12573-012-0053-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52629849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-01DOI: 10.1007/S12573-012-0052-9
T. Tajikawa, Yuya Imamura, Takaya Ohno, Fumiya Muranishi, M. Kubota, K. Ohba
{"title":"Measurement and analysis of the shape recovery process of each erythrocyte for estimation of its deformability using the microchannel technique: the influence of the softness of the cell membrane and viscosity of the hemoglobin solution inside the cell","authors":"T. Tajikawa, Yuya Imamura, Takaya Ohno, Fumiya Muranishi, M. Kubota, K. Ohba","doi":"10.1007/S12573-012-0052-9","DOIUrl":"https://doi.org/10.1007/S12573-012-0052-9","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"27 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S12573-012-0052-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52629837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-01DOI: 10.1007/S12573-012-0051-X
H. Yamada, N. Sakata
{"title":"Low pressure condition of a lipid core in an eccentrically developed carotid atheromatous plaque: a static finite element analysis","authors":"H. Yamada, N. Sakata","doi":"10.1007/S12573-012-0051-X","DOIUrl":"https://doi.org/10.1007/S12573-012-0051-X","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"27 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S12573-012-0051-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52629827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-01DOI: 10.1007/S12573-012-0056-5
Y. Abe, R. Sudo, M. Ikeda, K. Tanishita
{"title":"Steady and pulsatile shear stress induce different three-dimensional endothelial networks through pseudopodium formation","authors":"Y. Abe, R. Sudo, M. Ikeda, K. Tanishita","doi":"10.1007/S12573-012-0056-5","DOIUrl":"https://doi.org/10.1007/S12573-012-0056-5","url":null,"abstract":"","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"27 1","pages":"38-48"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S12573-012-0056-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52629887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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