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Assessing the Pathophysiology, Morbidity, and Mortality of Obstructive Sleep Apnea. 评估阻塞性睡眠呼吸暂停的病理生理学、发病率和死亡率。
Q3 Medicine Pub Date : 2024-10-30 DOI: 10.17849/insm-51-3-1-20.2
R C Richie

The basic definitions of obstructive sleep apnea (OSA), its epidemiology, it's clinical features and complications, and the morbidity and mortality of OSA are discussed. Included in this treatise is a discussion of the various symptomatic and polysomnographic phenotypes of COPD that may enable better treatment and impact mortality in persons with OSA. The goal of this article is to serve as a reference for life and disability insurance company medical directors and underwriters when underwriting an applicant with probable or diagnosed sleep apnea. It is well-referenced (133 ref.) allowing for more in-depth investigation of any aspect of sleep apnea being queried.

论述了阻塞性睡眠呼吸暂停(OSA)的基本定义、流行病学、临床特征和并发症,以及 OSA 的发病率和死亡率。本论文还讨论了慢性阻塞性肺疾病的各种症状和多导睡眠图表型,这些表型可帮助更好地治疗 OSA 患者并影响其死亡率。本文旨在为人寿和伤残保险公司的医疗主管和核保人员在核保可能或确诊患有睡眠呼吸暂停的申请人时提供参考。本文参考文献丰富(133 篇参考文献),可对睡眠呼吸暂停的任何方面进行更深入的调查。
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引用次数: 0
Varicose Veins as Model for Apportionment among Risk Factors for Compensation Purposes. 静脉曲张作为赔偿风险因素的分摊模型。
Q3 Medicine Pub Date : 2024-09-16 DOI: 10.17849/insm-51-3-1-9.2
Marc J Weber, Mark I Taragin

Objective.—: To demonstrate a method which is being used to apportion between risk factors for occupationally related disease and compensate individuals with multiple risk factors. The application to individuals will be demonstrated for varicose veins.

Background.—: The National Insurance Institute (NII) is tasked with compensating work related injuries and illness in Israel. Population attributable fraction (PAF) has been utilized in order to estimate the amount of disease that can potentially be eliminated in a population through the elimination of individual risk factors. PAF is based on relative risks and the prevalence of these risks.

Methods.—: A review of the medical literature consisting of epidemiological studies of varicose veins and its multiple risk factors was conducted, with special attention to prolonged occupational standing. Summary, weighted, relative risks were calculated for eight different risk factors. The proposed formula then allowed for apportioning among those risk factors in the individual.

Results.—: The findings of the current study indicate that prolonged standing may be associated with the presence of varicose veins, however in light of the multiple other risk factors associated, its overall contribution is generally minor.

Conclusion.—: Apportionment among multiple risk factors for varicose veins can be accomplished mathematically in individuals. This application is being applied successfully for other diseases as well.

目标:展示一种方法,该方法被用于分摊与职业有关的疾病的风险因素,并对具有多种风险因素的个人进行补偿。背景:国家保险研究所(NII)的任务是对与工作有关的工伤和职业病进行赔偿:国家保险研究所(NII)的任务是对以色列的工伤和疾病进行赔偿。人口可归因分数(PAF)被用来估算通过消除个人风险因素而可能在人口中消除的疾病数量。PAF 基于相对风险和这些风险的发生率:对有关静脉曲张及其多种风险因素的流行病学研究的医学文献进行了回顾,并特别关注了长期职业性站立。针对八种不同的风险因素,计算了加权相对风险汇总。然后,根据拟议的公式对这些风险因素在个人中进行分摊:目前的研究结果表明,长时间站立可能与静脉曲张的存在有关,但考虑到与之相关的其他多种风险因素,其总体影响一般较小:结论:静脉曲张的多种风险因素可以通过数学方法在个人身上进行分摊。这种应用也成功地应用于其他疾病。
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引用次数: 0
Beware the Black Widow at Claim Time: A Report of Three Cases. 当心索赔时的黑寡妇:三个案例的报告。
Q3 Medicine Pub Date : 2024-09-12 DOI: 10.17849/insm-51-3-1-6.2
Vera F Dolan

Moral hazard is well known to life insurance underwriters and medical directors to increase the risk of adverse consequences to insured individuals. The underwriting investigation of proposed insureds at time of policy issue is done to ensure no likely moral hazard exists. However, not all situations involving moral hazard may be identified at time of underwriting and policy issue, and may only be identified at time of claim. Three cases that were underwritten for life expectancies in legal matters are described here as examples of moral hazard identified at time of severe injury and/or death. All three of these cases involved a woman who manipulated her male partner into situations that increased the man's risk of severe injury and/or death to the woman's financial benefit. Such "black widows" made a great deal of effort over an extensive period of time to ensure that the moral hazard set up for their male partners resulted in a substantial financial windfall through litigation. The moral hazard set up by a black widow thus can be considered by the life insurance industry as sufficiently anti-selective and speculative to deny a claim at any time after policy issue.

人寿保险承保人和医务主任都知道,道德风险会增加投保人遭受不利后果的风险。在签发保单时对拟投保人进行核保调查,以确保不存在可能的道德风险。然而,并非所有涉及道德风险的情况都能在核保和签发保单时发现,可能只有在索赔时才能发现。这里介绍三个在法律事务中为预期寿命承保的案例,作为在严重伤害和/或死亡时发现道德风险的例子。所有这三个案例都涉及一名妇女操纵她的男性伴侣,使其陷入增加男性严重受伤和/或死亡风险的境地,从而使该妇女获得经济利益。这些 "黑寡妇 "在很长一段时间内做出了巨大努力,以确保为其男性伴侣设置的道德风险能够通过诉讼获得巨额经济利益。因此,人寿保险业认为,"黑寡妇 "设置的道德风险具有足够的反选择性和投机性,足以在保单签发后的任何时候拒绝理赔。
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引用次数: 0
The Long-term Complications of Covid-19 Infection. Covid-19感染的长期并发症
Q3 Medicine Pub Date : 2024-07-09 DOI: 10.17849/insm-51-2-1-4.2
Timothy Meagher

As the Covid-19 pandemic continues into its 4th year, reports of long-term morbidity and mortality are now attracting attention. Recent studies suggest that Covid-19 survivors are at increased risk of common illnesses, such as myocardial infarction, diabetes mellitus and autoimmune disorders. Mortality may also be increased. This article will review the evidence that supports some of these observations and provide an opinion about their validity and their relevance to insured cohorts.

随着 Covid-19 大流行进入第 4 个年头,有关长期发病率和死亡率的报告正引起人们的关注。最近的研究表明,Covid-19 的幸存者罹患心肌梗塞、糖尿病和自身免疫性疾病等常见疾病的风险增加。死亡率也可能增加。本文将回顾支持其中一些观察结果的证据,并就其有效性及其与投保人群的相关性发表看法。
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引用次数: 0
Through the Looking Glass Darkly: How May AI Models Influence Future Underwriting? 透过黑暗的望远镜:人工智能模型如何影响未来的核保?
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-59-63.1
Rodney C Richie

Applications of Artificial Intelligence (AI) deep-learning models to screening for clinical conditions continue to evolve. Instances provided in this treatise include using a simple one-view PA chest radiograph to screen for Type 2 Diabetes Mellitus (T2DM), congestive heart failure, valvular heart disease, and to assess mortality in asymptomatic persons with respiratory diseases. This technology incorporates hundreds of thousands of CXRs into a convoluted neural network and is generally named AI CXR. As an example, the AUROC (Area Under Receiving Operator Characteristic) of screening for T2DM was 0.84, with sensitivity and specificities that exceed those of the United States Preventative Services Task Force (USPSTF) guidelines for screening with HBA1c or blood glucose studies. The AUROC's for diagnosing ejection fractions less than 40% was 0.92, and for detecting valvular heart diseases was 0.87. The potential implications for underwriting life and disability policies may be significant. A companion article in the Journal of Insurance Medicine addresses this same technology using a simple 12-lead ECG, generally named AI ECGs.

人工智能(AI)深度学习模型在临床疾病筛查中的应用不断发展。本论文提供的实例包括使用简单的单视角 PA 胸片筛查 2 型糖尿病 (T2DM)、充血性心力衰竭、瓣膜性心脏病,以及评估无症状呼吸系统疾病患者的死亡率。这项技术将数十万张 CXR 纳入一个复杂的神经网络,一般被命名为 AI CXR。例如,筛查 T2DM 的 AUROC(接收操作者特征下面积)为 0.84,灵敏度和特异性都超过了美国预防服务工作组(USPSTF)关于使用 HBA1c 或血糖研究进行筛查的指南。诊断射血分数低于 40% 的 AUROC 为 0.92,检测瓣膜性心脏病的 AUROC 为 0.87。这对人寿保险和残疾保险的承保可能会产生重大影响。保险医学杂志》(Journal of Insurance Medicine)上的另一篇文章使用简单的 12 导联心电图(一般称为人工智能心电图)探讨了相同的技术。
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引用次数: 0
How the Medical Director Should Use Data Sources. 医务主任应如何使用数据源。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-1-31-34.1
Jean-Marc Fix

The life insurance industry is transitioning towards precision underwriting driven by increased data availability and access to advanced analytical tools. Effectively utilizing diverse data sources in life insurance underwriting presents an opportunity for medical directors to fully leverage their skillset in this evolving environment. By navigating these changes, balancing the value of data against its limitations, and fostering collaborative approaches to enhance risk assessment and underwriting processes, medical directors can maintain a pivotal role in the life insurance companies of tomorrow.

在数据可用性和先进分析工具日益普及的推动下,寿险业正在向精准核保转型。在寿险核保中有效利用各种数据源,为医务总监在这一不断变化的环境中充分发挥其技能提供了机会。通过驾驭这些变化,平衡数据的价值和局限性,并促进合作方法以加强风险评估和核保流程,医务总监可以在未来的寿险公司中保持举足轻重的地位。
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引用次数: 0
The Long-term Complications of Covid-19 Infection. Covid-19感染的长期并发症
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-111-115.1
Timothy Meagher

Context.—: As the Covid-19 pandemic continues into its 4th year, reports of long-term morbidity and mortality are now attracting attention. Recent studies suggest that Covid-19 survivors are at increased risk of common illnesses, such as myocardial infarction, diabetes mellitus and autoimmune disorders. Mortality may also be increased. This article will review the evidence that supports some of these observations and provide an opinion about their validity and their relevance to insured cohorts.

背景随着 Covid-19 大流行进入第四个年头,有关长期发病率和死亡率的报告正引起人们的关注。最近的研究表明,Covid-19 的幸存者罹患心肌梗塞、糖尿病和自身免疫性疾病等常见疾病的风险增加。死亡率也可能增加。本文将回顾支持其中一些观察结果的证据,并就其有效性及其与投保人群的相关性发表看法。
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引用次数: 0
Cancer of the Nasal Cavity, Middle Ear and Accessory Sinuses - 15 Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration and Topographic Primary Sites: A Systematic Review of 13,404 Cases for Diagnosis Years 2000-2017: (NCI SEER*Stat 8.3.8). 鼻腔、中耳和附属鼻窦癌症--按年龄、性别、种族、分期、分级、队列进入时间段、疾病持续时间和地形原发部位的 15 年生存率和死亡率比较分析:对 2000-2017 年诊断的 13,404 个病例的系统回顾:(NCI SEER*Stat 8.3.8)。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-77-91.1
Anthony F Milano
<p><strong>Background: </strong>.-Sinonasal malignancies are rare, aggressive, deadly and challenging tumors to diagnose and treat. Since 2000, age-adjusted incidence rates average less than 1 case per 100,000 per year, male and female combined, in the United States. For the entire cohort, 2000-2017, overall median age-onset was 62.6 years. Carcinoma constitutes over 90% of these upper respiratory cancers and most cases are advanced, more than 72% (regional or distant stage) when the diagnosis is made. Composite mortality at 5 years was 108 excess deaths/1000/year with a mortality ratio of 558%, and 41% of deaths occurred in this time frame. As a consequence, observed median survival was approximately 6 years with 5-year cumulative observed survival (P) and relative survival rates (SR) 53% and 60%. This mortality and survival update study follows the World Health Organization International Classification of Diseases for Oncology-3rd Edition (ICD-O-3)1 topographical identification, coding, labeling and listing of 13,404 patient-cases accessible for analysis in the United States National Cancer Institute's Surveillance, Epidemiology and End Results program (NCI SEER Research Data, 18 Registries), 2000-2017 located in 8 primary anatomical sites: C30.0-Nasal cavity, C30.1-Middle ear, C31.0-Maxillary sinus, C31.1-Ethmoid sinus, C31.2-Frontal sinus, C31.3-Sphenoid sinus, C31.8-Overlapping lesion of accessory sinuses, C31.9-Accessory sinus, NOS.</p><p><strong>Objectives: </strong>.-1) Utilize national population-based SEER registry data for 2000-2017 to update cancer survival and mortality outcomes for 8 ICD-O-3 topographically coded sinonasal primary sites. 2) Discern similarities and contrasts in NCI-SEER case characteristics. 3) Identify current risk pattern outcomes and shifts in United States citizens, 2000-2017.</p><p><strong>Methods: </strong>.-SEER Research Data, 18 Registries, Nov 2019 Sub (2000-2017)2,3 are used to examine the risk consequences of 13,404 patients diagnosed with sinonasal malignancies, 2000-2017, in this retrospective population-based study employing prognostic data stratified by topography, age, sex, race, stage, grade, 2 cohort entry time-periods (2000-06 & 2007-17), and disease-duration to 15 years. General methods and standard double decrement life table methodologies for displaying and converting SEER site-specific annual survival and mortality data to aggregate average annual data units in durational intervals of 0-1, 0-2, 1-2, 2-5, 0-5, 5-10, and 10-15 years are employed. The reader is referred to the "Registrar Staging Assistant (SEER*RSA)" for local-regional-distant Extent of Disease (EOD) sources used in the development of staging descriptions for the Nasal Cavity and Paranasal Sinuses (maxillary and ethmoid sinuses only) and Summary Stage 2018 Coding Manual v2.0 released September 1, 2020. Cancer staging & grading procedural explanations, statistical significance & 95% confidence levels4 are described in previous Jou
背景:......窦道恶性肿瘤是一种罕见、侵袭性强、致命、诊断和治疗难度大的肿瘤。自2000年以来,在美国,经年龄调整后的发病率平均每年每10万名男性和女性中不到1例。在 2000-2017 年的整个队列中,发病年龄的总体中位数为 62.6 岁。在这些上呼吸道癌症中,90% 以上为癌肿,大多数病例在确诊时已属晚期,超过 72%(区域或远处分期)。5 年的综合死亡率为 108 例死亡/1000 例/年,死亡率为 558%,41% 的死亡发生在这一时期。因此,观察到的中位生存期约为 6 年,5 年累计观察生存期(P)和相对生存率(SR)分别为 53% 和 60%。这项死亡率和生存率更新研究采用了世界卫生组织《国际肿瘤疾病分类-第 3 版》(ICD-O-3)1 的地形识别、编码、标签和列表方法,对美国国家癌症研究所的监测、流行病学和最终结果计划(NCI SEER 研究数据,18 个登记处)中 2000-2017 年可获得的 13,404 例患者病例进行了分析,这些病例分布在 8 个主要解剖部位:C30.0-鼻腔、C30.1-中耳、C31.0-下颌窦、C31.1-蝶窦、C31.2-额窦、C31.3-蝶窦、C31.8-附属窦重叠病变、C31.9-附属窦,NOS。目标:.-1)利用 2000-2017 年基于人群的 SEER 登记数据,更新 8 个 ICD-O-3 拓扑编码鼻窦原发部位的癌症生存率和死亡率结果。2) 识别 NCI-SEER 病例特征的相似性和对比性。3) 确定 2000-2017 年美国公民当前的风险模式结果和转变。-在这项基于人群的回顾性研究中,采用了按地形、年龄、性别、种族、分期、分级、2 个队列进入时间段(2000-06 年和 2007-17 年)和病程达 15 年的分层预后数据,对 2000-2017 年诊断为鼻窦恶性肿瘤的 13404 名患者的风险后果进行了研究。采用一般方法和标准双减生命表方法显示 SEER 特定地点的年度存活率和死亡率数据,并将其转换为以 0-1、0-2、1-2、2-5、0-5、5-10 和 10-15 年为持续时间间隔的年均数据单位。读者可参阅 "注册医师分期助手(SEER*RSA)",了解用于制定鼻腔和副鼻窦(仅限上颌窦和乙状窦)分期描述的本地-区域-远处疾病范围(EOD)来源,以及 2020 年 9 月 1 日发布的《2018 年摘要分期编码手册》v2.0。癌症分期和分级的程序解释、统计意义和 95% 置信度4 在之前的《保险医学杂志》文章5,6 和其他出版物7,8 中有所描述。本研究中使用了基于观察到的死亡人数的 95% 水平的泊松置信区间,但为了节省死亡率表格的空间,此处未予显示。结果:......在 SEER 18 登记处中,共有 13,404 例患者(2000-2017 年)可用于分析,其发病率低于每 10 万人 1 例。在这组病例中,共分析了10624名患者的存活率和死亡率。男性占病例的 59.3%,女性占 40.7%。白人占病例的 80.3%,黑人、其他和未知患者占 19.7%。最常见的恶性肿瘤解剖部位是鼻腔(49.7%),最少见的是额窦(1.2%)。从确诊开始,在8个原发部位中,第一年死亡率q从14.3%(C30.0-鼻腔)到30.2%(C31.8-重叠窦)不等,相应的超额死亡率(EDR)分别为118/1000/年和279/1000/年。就单一部位而言,鼻腔的 5 年累积生存率(SR)最高(69.5%),附属窦重叠病变的 5 年累积生存率(SR)最低(47.2%),超额死亡率(EDR)分别为 76/1000/ 年和 169/1000/ 年。结论:......8 个鼻窦癌原发部位的特点是局部阶段的病例比例较低(28%)。由于即使在局部化疗阶段死亡率也很高,因此所有患者的总体预后都很差。鼻窦鼻道癌症的超额死亡率在确诊和治疗后长达 10-15 年持续存在。在 15 年的持续时间内,所有鼻窦部位癌症的超额死亡率仍为 27.6‰/年,累计生存率(SR)持续下降至 43.9%。
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引用次数: 0
Unlocking Hidden Risks: Harnessing Artificial Intelligence (AI) to Detect Subclinical Conditions from an Electrocardiogram (ECG). 揭开隐藏的风险:利用人工智能(AI)从心电图(ECG)中检测亚临床病症。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-64-76.1
Emoke Posan, Rod Richie

Recent artificial intelligence (AI) advancements in cardiovascular medicine offer potential enhancements in diagnosis, prediction, treatment, and outcomes. This article aims to provide a basic understanding of AI enabled ECG technology. Specific conditions and findings will be discussed, followed by reviewing associated terminology and methodology. In the appendix, definitions of AUC versus accuracy are explained. The application of deep learning models enables detecting diseases from normal electrocardiograms at accuracy not previously achieved by technology or human experts. Results with AI enabled ECG are encouraging as they considerably exceeded current screening models for specific conditions (i.e., atrial fibrillation, left ventricular dysfunction, aortic stenosis, and hypertrophic cardiomyopathy). This could potentially lead to a revitalization of the utilization of the ECG in the insurance domain. While we are embracing the findings with this rapidly evolving technology, but cautious optimism is still necessary at this point.

人工智能(AI)在心血管医学领域的最新进展为诊断、预测、治疗和预后提供了潜在的提升空间。本文旨在介绍人工智能心电图技术的基本知识。文章将讨论具体病症和研究结果,然后回顾相关术语和方法。附录中将解释 AUC 与准确度的定义。应用深度学习模型可以从正常心电图中检测出疾病,其准确性是以前的技术或人类专家无法达到的。人工智能心电图的结果令人鼓舞,因为它们大大超过了目前针对特定病症(即心房颤动、左心室功能障碍、主动脉瓣狭窄和肥厚型心肌病)的筛查模型。这有可能使心电图在保险领域的应用重新焕发生机。虽然我们对这项快速发展的技术的研究结果表示欢迎,但目前仍有必要保持谨慎乐观的态度。
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引用次数: 0
Fetal Alcohol Spectrum Disorder. 胎儿酒精紊乱症。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-55-58.1
Rodney C Richie
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引用次数: 0
期刊
Journal of insurance medicine (New York, N.Y.)
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