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Journal of insurance medicine (New York, N.Y.)最新文献

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Metabolic Muddle. MASLD and MASH on the Horizon. 代谢混乱地平线上的 MASLD 和 MASH。
Q3 Medicine Pub Date : 2023-07-01 DOI: 10.17849/insm-50-2-147-149.1
Timothy Meagher

NAFLD (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis) are time-honored acronyms, with widely popular acceptance. Experts now recommend discarding them in favor of MASLD for "metabolic dysfunction-associated steatotic liver disease" and MASH for "metabolic dysfunction-associated steatohepatitis." The reasons for this change are explored and an argument about why the change is confusing, is advanced. Should these acronyms become clinically popular, risk assessment manuals will require updates.

NAFLD(非酒精性脂肪肝)和 NASH(非酒精性脂肪性肝炎)是历史悠久的缩略词,已被广泛接受。现在,专家建议摒弃它们,改用 MASLD 表示 "代谢功能障碍相关性脂肪性肝病",MASH 表示 "代谢功能障碍相关性脂肪性肝炎"。本文探讨了这一变化的原因,并提出了为什么这一变化会造成混淆的论点。如果这些缩写在临床上流行起来,风险评估手册将需要更新。
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引用次数: 0
Prevalence of Antibodies to COVID-19 Due to Infection or Vaccination in US Adults. 美国成年人因感染或接种疫苗而产生的COVID-19抗体患病率
Q3 Medicine Pub Date : 2023-05-24 DOI: 10.17849/insm-50-01-02.1
Robert L Stout, Steven J Rigatti

Objective: -Determine the seroprevalence of SARS-CoV-2 infection and vaccination in a population applying for life insurance.

Setting: -This is a cross-sectional study of 2584 US life insurance applicants, to determine the seroprevalence of antibodies to COVID-19. This convenience sample was selected on two consecutive days April 25-26, 2022.

Results: -For COVID-19, 97.3% are seropositive, and 63.9% have antibodies to nucleocapsid protein, a marker of prior infection. An additional, 33.7% have been vaccinated with no serologic evidence of infection.

Methodology: -Serum and urine samples from a nationwide group of insurance applicants for routine risk assessment were collected. The examination of applicants typically occurs, in their homes, their place of employment, or a clinic. The paramedic exam occurs 7-14 days after the insurance application. Before the exam, an office assistant calls the applicant and inquires if they have been in contact with a person with SARS-CoV-2, been ill within the last 2 weeks, felt sick, or recently had a fever. If the applicant answers yes, the exam is rescheduled. Before sample collection, the applicant reads and signs a consent form to release medical information and testing. Next, the examiner records the applicant's blood pressure, height, and weight. Then, a blood and a urine sample are collected and sent with the consent form to our laboratory via Federal Express. On April 25-26, 2022, we tested 2584 convenience samples from adult insurance applicants for the presence of antibodies to nucleocapsid and spike proteins from SARS-CoV-2. As a standard practice, we reported the client-specified test profile results to our life insurance carriers. In contrast, the COVID-19 test results were only available to the authors. Patient and Public Involvement.-There was no patient involvement in study design, reporting of results, or journal publication selection. There was patient consent to publish de-identified study results. No public involvement occurred in the creation or completion of the study. The authors thank the participants in this study for approving the use of their blood samples to further society's understanding of the SARS-CoV-19 pandemic. Ethics Review.-Western Institutional Review Board reviewed the study design and determined it to be exempt under the Common Rule and applicable guidance. Therefore, it is exempt under 45 CFR § 46.104(d)(4) from using de-identified study samples for epidemiologic investigation, WIRB Work Order #1-1324846-1. In addition, all test subjects had signed a consent allowing research of their blood and urine samples with the removal of personally identifiable information.

Results: -The combined seroprevalence for antibodies to nucleocapsid, a marker of prior infection, and antibodies to spike protein, an indicator of either previous infection or vaccination, was 97.3%.

目的:了解某寿险投保人群SARS-CoV-2感染及疫苗接种情况。-这是一项针对2584名美国人寿保险申请人的横断面研究,以确定COVID-19抗体的血清阳性率。这个方便样本是在2022年4月25日至26日连续两天选择的。结果:- COVID-19血清阳性97.3%,核衣壳蛋白抗体阳性63.9%,核衣壳蛋白抗体是既往感染的标志。此外,33.7%的人接种了疫苗,但没有血清学感染证据。方法:从全国范围内的保险申请人群体中收集血清和尿液样本进行常规风险评估。对申请人的检查通常在他们的家中、工作地点或诊所进行。护理人员考试在保险申请后7-14天进行。在考试前,办公室助理会打电话给申请人,询问他们是否与SARS-CoV-2患者有过接触,是否在过去两周内生病,是否感到不适或最近发烧。如果答案是肯定的,考试将重新安排。在样本采集前,申请人阅读并签署一份同意书,以公布医疗信息和测试结果。接下来,考官记录申请人的血压、身高和体重。然后采集血样和尿样,连同同意书一起通过联邦快递送到我们的实验室。2022年4月25日至26日,我们检测了2584份来自成人保险申请人的便利样本中是否存在SARS-CoV-2的核衣壳和刺突蛋白抗体。作为一项标准实践,我们将客户指定的测试概要结果报告给我们的人寿保险公司。相比之下,COVID-19检测结果仅供作者使用。病人和公众的参与。-没有患者参与研究设计、结果报告或期刊发表选择。患者同意发表去标识的研究结果。在研究的创建和完成过程中没有公众参与。作者感谢本研究的参与者批准使用他们的血液样本,以进一步增进社会对SARS-CoV-19大流行的了解。伦理审查。-西方机构审查委员会审查了研究设计,并根据共同规则和适用指南确定其豁免。因此,根据45 CFR§46.104(d)(4), WIRB工作令#1-1324846-1,可豁免使用去鉴定研究样本进行流行病学调查。此外,所有测试对象都签署了一份同意书,允许对他们的血液和尿液样本进行研究,并删除个人身份信息。结果:-核衣壳抗体(既往感染的标志)和刺突蛋白抗体(既往感染或接种的标志)的联合血清阳性率为97.3%。较年轻的年龄组与较年长的年龄组感染率较高,接种疫苗和获得自然免疫之间存在非统计差异。对于16-84岁年龄组,美国估计的COVID-19血清总患病率为2.49亿例。结论:-由于先前感染或接种疫苗,美国人群对当前的COVID-19变体具有广泛的免疫抗性。独立于既往感染或疫苗接种的新变异体和隐性疾病的传染性是临床SARS-CoV-2病例散发增加的驱动力。
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引用次数: 1
Long Covid - Into the Third Year. 长冠-进入第三年。
Q3 Medicine Pub Date : 2023-05-24 DOI: 10.17849/insm-50-1-1-5.1
Timothy Meagher

As the COVID-19 pandemic reaches the end of its third year, and as COVID-related mortality in North America wanes, long Covid and its disabling symptoms are attracting more attention. Some individuals report symptoms lasting more than 2 years, and a subset report continuing disability. This article will provide an update on long Covid, with a particular focus on disease prevalence, disability, symptom clustering and risk factors. It will also discuss the longer-term outlook for individuals with long Covid.

随着Covid -19大流行进入第三年的尾声,随着北美Covid -19相关死亡率的下降,Covid -19及其致残症状引起了越来越多的关注。有些人报告症状持续2年以上,还有一部分人报告持续残疾。本文将提供关于新冠肺炎的最新情况,特别关注疾病流行、残疾、症状聚类和风险因素。会议还将讨论长期感染Covid的个人的长期前景。
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引用次数: 0
Prostate cancer. 前列腺癌。
Q3 Medicine Pub Date : 2023-03-21 DOI: 10.1002/0470041102.ch18
R. E. Frank
Prostate cancer is the most common internal cancer in American males. There are many variables that effect prognosis, with the Gleason scoring system being one of the most important factors. There is controversy regarding the ideal treatment in various subsets of prostate cancer patients. Posttreatment prostate specific antigen values have prognostic significance.
前列腺癌是美国男性最常见的内部癌症。影响预后的因素有很多,其中格里森评分系统是最重要的因素之一。对于不同亚群前列腺癌患者的理想治疗方法存在争议。治疗后前列腺特异性抗原值具有预后意义。
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引用次数: 0
Lip Cancer: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration A Systematic Review of 19,213 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5). 唇癌:按年龄、性别、种族、分期、分级、队列进入时间和疾病持续时间划分的20年生存率和死亡率比较分析:1973-2014年19,213例诊断病例的系统回顾:(SEER*Stat 8.3.5)。
Q3 Medicine Pub Date : 2023-03-07 DOI: 10.17849/insm-49-4-1-12.1
Anthony F Milano

This report summarizes the incidence, relative frequency distributions and survival & mortality by age, sex, stage and grade, of adult invasive primary cancers of the lip in two entrant time-periods as recorded in the SEER Program of the National Cancer Institute for diagnosis years 1973-2014 (SEER Stat 8.3.5). While the occurrence rates and frequency are low in the United States, they are exceptionally important from a clinical and surgical standpoint because of the morphological and functional changes involved.

本报告总结了1973-2014年美国国家癌症研究所SEER项目诊断年份(SEER Stat 8.3.5)中记录的两个进入期成人侵袭性原发性唇部癌的发病率、相对频率分布、生存率和死亡率,按年龄、性别、分期和分级。虽然美国的发生率和频率较低,但由于涉及形态学和功能改变,从临床和外科的角度来看,它们非常重要。
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引用次数: 0
Proactive Outreach for At-risk Health Plan Members During COVID-19 Pandemic in New Mexico. 在新墨西哥州COVID-19大流行期间,为高危健康计划成员提供积极外展服务。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-1-10.1
Victoria C Dirmyer, Ingrid Wurpts, Gray Clarke, Lane Evans, Cynthia Al-Aghbary, Kalyani Gopalan, Soyal Momin

Objective: -Explore the impact of proactive outreach to a health plan population during COVID-19 pandemic in New Mexico.

Background: -By March 2020, the 2019 novel coronavirus (COVID-19) was a global pandemic, circulating in more than 114 countries. As more information about virus transmission, symptoms, and comorbidities were reported over time, recommendations for reducing the spread of the virus within communities was provided by leading health organizations like the Centers for Disease Control and Prevention (CDC).

Methods: -Criteria were developed to identify health plan members most at risk for virus complications. Once members were identified, a health plan representative contacted each member to inquire about member needs, questions, and provide them with resources. Members were then tracked for COVID-19 testing results and vaccination status.

Results: -Overall, 50,000+ members received an outreach call (during 8-month timeframe), and 26,000 calls were tracked for member outcomes. Over 50% of the outreach calls were answered by the health plan member. Of the members who were called, 1186 (4.4%) tested positive for COVID-19. Health plan members that could not be reached represented 55% of the positive cases. A chi-square test of the two populations (reached vs unable to reach) showed a significant difference in COVID-19 positive test results (N = 26,663, X2(1) = 16.33, P<0.01).

Conclusions: -Community outreach was related to lower rates of COVID-19. Community connection is important, especially in tumultuous times, and proactive outreach to the community provides an opportunity for information sharing and community bonding.

目的:-探索新墨西哥州在COVID-19大流行期间对健康计划人群进行主动外展的影响。背景:到2020年3月,2019年新型冠状病毒(COVID-19)已成为全球大流行,在114多个国家传播。随着时间的推移,有关病毒传播、症状和合并症的信息越来越多,疾病控制和预防中心(CDC)等主要卫生组织提出了减少病毒在社区内传播的建议。方法:制定标准以确定最有可能发生病毒并发症的健康计划成员。一旦确定了成员,健康计划代表就会联系每个成员,询问成员的需求和问题,并为他们提供资源。然后跟踪成员的COVID-19检测结果和疫苗接种状况。结果:总体而言,50,000多名会员接到了外展电话(在8个月的时间框架内),26,000个电话被跟踪以了解会员的结果。超过50%的外展电话是由健康计划成员接听的。在被传唤的成员中,1186人(4.4%)被检测出新冠病毒阳性。无法接触到的健康计划成员占阳性病例的55%。两组人群(到达与无法到达)的卡方检验显示COVID-19阳性检测结果有显著差异(N = 26,663, X2(1) = 16.33, p)结论:社区外展与较低的COVID-19发病率有关。社区联系很重要,特别是在动荡时期,积极主动地向社区伸出援手为信息共享和社区联系提供了机会。
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引用次数: 0
Mortality Statistics in Asthma. 哮喘死亡率统计。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-04-244-249.1
Rodney C Richie

This article summarizes the mortality associated with asthma and was created from a presentation given at the 130th AAIM Annual Meeting.

这篇文章总结了与哮喘相关的死亡率,并根据第130届AAIM年会上的一份报告创建。
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引用次数: 0
Normal Transaminases in Methamphetamine- and Heroin-Associated Hyperammonemic Encephalopathy. 甲基苯丙胺和海洛因相关性高氨血症脑病的正常转氨酶。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-2-4.1
Vera F Dolan

Detecting undisclosed methamphetamine and heroin abuse is a challenge for life underwriters and medical directors. A common clinical assumption is that if substance abusers experience liver damage, it will be indicated by elevated serum transaminases. The following case suggests that assumption may not be true for heavy substance abusers who consume no or minimal alcohol. This report describes a 44-year-old male with long-term use of inhaled combined methamphetamine and heroin ("speedballs") and minimal alcohol use, whose transaminases remained normal while episodes of acute liver failure and transient hepatic encephalopathy from hyperammonemia were observed. In this case, a fatal motor vehicle accident occurred following the sudden onset of hepatic encephalopathy hours after consuming a "speedball." Normal transaminases may not be proof of a normal healthy liver among methamphetamine and heroin abusers.

检测未公开的甲基苯丙胺和海洛因滥用对寿险保险公司和医疗主管来说是一个挑战。一个常见的临床假设是,如果药物滥用者经历肝损害,它将表明血清转氨酶升高。下面的案例表明,对于不饮酒或少量饮酒的重度药物滥用者来说,这种假设可能不成立。本报告描述了一名44岁男性,长期吸入甲基苯丙胺和海洛因(“速球”)并少量饮酒,其转氨酶保持正常,但观察到急性肝功能衰竭和高氨血症引起的一过性肝性脑病发作。在这个案例中,一个致命的机动车事故发生在肝性脑病的突然发作数小时后,食用“速度球”。在甲基苯丙胺和海洛因滥用者中,正常的转氨酶可能不是肝脏正常健康的证明。
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引用次数: 0
Critical Illness at 40: Still a Thorn in the Medical Director's Side. 40岁时的危重疾病:仍然是医学主任的眼中钉。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-3-3.1
Timothy Meagher

Critical illness insurance was introduced 40 years ago. Medical directors continue to be challenged and frustrated with the complexities that critical illness claims offer. This article provides insights into the continued issues and possible solutions.

重病保险是40年前推出的。医疗主管继续受到挑战和沮丧的复杂性,危重疾病索赔提供。本文提供了对持续存在的问题和可能的解决方案的见解。
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引用次数: 0
Morbidity and Mortality Associated with Chronic Obstructive Pulmonary Disease (COPD). 慢性阻塞性肺疾病(COPD)的发病率和死亡率。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-04-230-243.1
Rodney C Richie

This article summarizes the morbidity and mortality associated with COPD and was created from a presentation given at the 130th AAIM Annual Meeting. The author reviews what most medical directors already know about COPD, but with particular attention paid to the Pulmonary Function Tests dealing with spirometry. Underwriters and medical directors need to understand the three basic measurements of spirometry (FVC, FEV1, and FEF25-75), as well as the significance of the FEV1/FVC ratio, in establishing an applicant as having an obstructive or restrictive impairment.

这篇文章总结了COPD相关的发病率和死亡率,是根据第130届AAIM年会上的一份报告编写的。作者回顾了大多数医学主任已经知道的关于慢性阻塞性肺病,但特别关注肺功能测试处理肺活量测定。承保人和医疗主管需要了解肺活量测定法的三个基本测量值(FVC、FEV1和FEF25-75),以及FEV1/FVC比值在确定申请人是否患有阻塞性或限制性损伤方面的重要性。
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引用次数: 0
期刊
Journal of insurance medicine (New York, N.Y.)
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