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Journal of insurance medicine (New York, N.Y.)最新文献

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The Survival Benefit of Pancreas Transplantation: Considerations for Insurance Coverage. 胰腺移植的生存益处:保险承保的考虑因素。
Q3 Medicine Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00031.1
Angelika C Gruessner, Rainer W G Gruessner
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引用次数: 0
Non-Physiologic Doses of Androgenic Anabolic Steroids: Mortality and Underwriting Assessment. 非生理性剂量的雄性同化类固醇:死亡率和承保评估。
Q3 Medicine Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00028.1
John R Iacovino

Little evidence based information exists in the medical literature on the mortality of abusers of anabolic androgenic steroids. These individuals range from competitive athletes and body builders to those whose who use physician prescribed mega-doses. Life insurance medical directors have little guidance on how to underwrite these individuals when presented with their applications. A recent article presented a Kaplan-Meir mortality curve accompanied with a control population demonstrating the mortality of these individuals over a 13-year period. Users of non-physiologic doses of anabolic androgenic steroids experience a mortality about two times the expected mortality of the control population. They should be underwritten with ratings commensurate with their anabolic androgenic steroid abuse and demonstrated mortality.

医学文献中几乎没有关于合成代谢雄性类固醇滥用者死亡率的循证信息。这些人既包括竞技运动员和健美运动员,也包括使用医生开具的超大剂量药物的人。人寿保险公司的医学主管对如何承保这些人的申请几乎没有指导。最近的一篇文章展示了一条 Kaplan-Meir 死亡率曲线,并附有一个对照人群,显示了这些人在 13 年间的死亡率。使用非生理剂量合成代谢雄性类固醇者的死亡率约为对照人群预期死亡率的两倍。应根据他们滥用合成代谢雄性类固醇的情况和显示的死亡率对他们进行相应的评级。
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引用次数: 0
Innovative Strategies and Insurance Consequences for Implementing Universal Health Insurance in the United States. 在美国实施全民健康保险的创新战略和保险后果。
Q3 Medicine Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00014.1
Rainer W G Gruessner

Universal Health Insurance does not exist in the United States for two reasons: (1) there is a general unwillingness to dismantle the historically grown framework of the world's most complex mix of public and private sector health coverage and (2) mere cost considerations. The first concern can be abated by establishing a Universal Health Insurance system which retains many or most of the historically grown infrastructure. Cost containment of such a reform is addressed herein in that the two proposed pathways comprise either (1) a leveled solution through Medicare-expansion for the uninsured only or (2) a more complex solution through a national, 2-tier healthcare system for all Americans. Both pathways are based on solid financing without major tax increases by using existing and/or yet untapped funding sources. The insurance consequences for both options are assessable. They are minor for the Medicare-expansion and more wide-ranging, yet also achievable, for a national, 2-tier healthcare system. Universal Health Insurance must no longer be an illusion that continues to haunt our society in the 21st century.

美国没有全民健康保险有两个原因:(1) 人们普遍不愿意拆除历史上形成的世界上最复杂的公共和私营部门混合健康保险框架;(2) 只是出于成本考虑。建立全民健康保险制度,保留许多或大部分历史上发展起来的基础设施,可以缓解第一种担忧。本文将讨论这种改革的成本控制问题,建议的两种途径包括:(1) 仅通过扩大医疗保险范围为未参保者提供公平的解决方案;(2) 通过为所有美国人建立一个全国性的两级医疗保健系统提供更为复杂的解决方案。这两种方案的基础都是在不大幅增税的情况下,利用现有和/或尚未开发的资金来源进行稳健融资。两种方案的保险后果都是可以评估的。对于扩大医疗保险来说,其影响较小,而对于全国性的两级医疗保健系统来说,其影响范围更广,但也是可以实现的。全民医疗保险决不能再成为 21 世纪继续困扰我们社会的幻想。
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引用次数: 0
Assessing the Pathophysiology, Morbidity, and Mortality of Obstructive Sleep Apnea. 评估阻塞性睡眠呼吸暂停的病理生理学、发病率和死亡率。
Q3 Medicine Pub Date : 2024-11-01 DOI: 10.17849/insm-51-3-1-20.2
R C Richie

The basic definitions of obstructive sleep apnea (OSA), its epidemiology, its clinical features and complications, and the morbidity and mortality of OSA are discussed. Included in this treatise is a discussion of the various symptomatic and polysomnographic phenotypes of COPD that may enable better treatment and impact mortality in persons with OSA. The goal of this article is to serve as a reference for life and disability insurance company medical directors and underwriters when underwriting an applicant with probable or diagnosed sleep apnea. It is well-referenced (133 ref.) allowing for more in-depth investigation of any aspect of sleep apnea being queried.

论述了阻塞性睡眠呼吸暂停(OSA)的基本定义、流行病学、临床特征和并发症,以及 OSA 的发病率和死亡率。本论文还讨论了慢性阻塞性肺疾病的各种症状和多导睡眠图表型,这些表型可帮助更好地治疗 OSA 患者并影响其死亡率。本文旨在为人寿和伤残保险公司的医疗主管和核保人员在核保可能或确诊患有睡眠呼吸暂停的申请人时提供参考。本文参考文献丰富(133 篇参考文献),可对睡眠呼吸暂停的任何方面进行更深入的调查。
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引用次数: 0
Autoimmune Diseases following COVID-19 Infection: How Solid is the Evidence? 感染 COVID-19 后的自身免疫性疾病:证据有多充分?
Q3 Medicine Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00026.1
Timothy Meagher
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引用次数: 0
The Long-term Complications of Covid-19 Infection. Covid-19感染的长期并发症
Q3 Medicine Pub Date : 2024-07-09 DOI: 10.17849/insm-51-2-1-4.2
Timothy Meagher

As the Covid-19 pandemic continues into its 4th year, reports of long-term morbidity and mortality are now attracting attention. Recent studies suggest that Covid-19 survivors are at increased risk of common illnesses, such as myocardial infarction, diabetes mellitus and autoimmune disorders. Mortality may also be increased. This article will review the evidence that supports some of these observations and provide an opinion about their validity and their relevance to insured cohorts.

随着 Covid-19 大流行进入第 4 个年头,有关长期发病率和死亡率的报告正引起人们的关注。最近的研究表明,Covid-19 的幸存者罹患心肌梗塞、糖尿病和自身免疫性疾病等常见疾病的风险增加。死亡率也可能增加。本文将回顾支持其中一些观察结果的证据,并就其有效性及其与投保人群的相关性发表看法。
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引用次数: 0
Through the Looking Glass Darkly: How May AI Models Influence Future Underwriting? 透过黑暗的望远镜:人工智能模型如何影响未来的核保?
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-59-63.1
Rodney C Richie

Applications of Artificial Intelligence (AI) deep-learning models to screening for clinical conditions continue to evolve. Instances provided in this treatise include using a simple one-view PA chest radiograph to screen for Type 2 Diabetes Mellitus (T2DM), congestive heart failure, valvular heart disease, and to assess mortality in asymptomatic persons with respiratory diseases. This technology incorporates hundreds of thousands of CXRs into a convoluted neural network and is generally named AI CXR. As an example, the AUROC (Area Under Receiving Operator Characteristic) of screening for T2DM was 0.84, with sensitivity and specificities that exceed those of the United States Preventative Services Task Force (USPSTF) guidelines for screening with HBA1c or blood glucose studies. The AUROC's for diagnosing ejection fractions less than 40% was 0.92, and for detecting valvular heart diseases was 0.87. The potential implications for underwriting life and disability policies may be significant. A companion article in the Journal of Insurance Medicine addresses this same technology using a simple 12-lead ECG, generally named AI ECGs.

人工智能(AI)深度学习模型在临床疾病筛查中的应用不断发展。本论文提供的实例包括使用简单的单视角 PA 胸片筛查 2 型糖尿病 (T2DM)、充血性心力衰竭、瓣膜性心脏病,以及评估无症状呼吸系统疾病患者的死亡率。这项技术将数十万张 CXR 纳入一个复杂的神经网络,一般被命名为 AI CXR。例如,筛查 T2DM 的 AUROC(接收操作者特征下面积)为 0.84,灵敏度和特异性都超过了美国预防服务工作组(USPSTF)关于使用 HBA1c 或血糖研究进行筛查的指南。诊断射血分数低于 40% 的 AUROC 为 0.92,检测瓣膜性心脏病的 AUROC 为 0.87。这对人寿保险和残疾保险的承保可能会产生重大影响。保险医学杂志》(Journal of Insurance Medicine)上的另一篇文章使用简单的 12 导联心电图(一般称为人工智能心电图)探讨了相同的技术。
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引用次数: 0
How the Medical Director Should Use Data Sources. 医务主任应如何使用数据源。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-1-31-34.1
Jean-Marc Fix

The life insurance industry is transitioning towards precision underwriting driven by increased data availability and access to advanced analytical tools. Effectively utilizing diverse data sources in life insurance underwriting presents an opportunity for medical directors to fully leverage their skillset in this evolving environment. By navigating these changes, balancing the value of data against its limitations, and fostering collaborative approaches to enhance risk assessment and underwriting processes, medical directors can maintain a pivotal role in the life insurance companies of tomorrow.

在数据可用性和先进分析工具日益普及的推动下,寿险业正在向精准核保转型。在寿险核保中有效利用各种数据源,为医务总监在这一不断变化的环境中充分发挥其技能提供了机会。通过驾驭这些变化,平衡数据的价值和局限性,并促进合作方法以加强风险评估和核保流程,医务总监可以在未来的寿险公司中保持举足轻重的地位。
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引用次数: 0
The Long-term Complications of Covid-19 Infection. Covid-19感染的长期并发症
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-111-115.1
Timothy Meagher

Context.—: As the Covid-19 pandemic continues into its 4th year, reports of long-term morbidity and mortality are now attracting attention. Recent studies suggest that Covid-19 survivors are at increased risk of common illnesses, such as myocardial infarction, diabetes mellitus and autoimmune disorders. Mortality may also be increased. This article will review the evidence that supports some of these observations and provide an opinion about their validity and their relevance to insured cohorts.

背景随着 Covid-19 大流行进入第四个年头,有关长期发病率和死亡率的报告正引起人们的关注。最近的研究表明,Covid-19 的幸存者罹患心肌梗塞、糖尿病和自身免疫性疾病等常见疾病的风险增加。死亡率也可能增加。本文将回顾支持其中一些观察结果的证据,并就其有效性及其与投保人群的相关性发表看法。
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引用次数: 0
Cancer of the Nasal Cavity, Middle Ear and Accessory Sinuses - 15 Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration and Topographic Primary Sites: A Systematic Review of 13,404 Cases for Diagnosis Years 2000-2017: (NCI SEER*Stat 8.3.8). 鼻腔、中耳和附属鼻窦癌症--按年龄、性别、种族、分期、分级、队列进入时间段、疾病持续时间和地形原发部位的 15 年生存率和死亡率比较分析:对 2000-2017 年诊断的 13,404 个病例的系统回顾:(NCI SEER*Stat 8.3.8)。
Q3 Medicine Pub Date : 2024-07-01 DOI: 10.17849/insm-51-2-77-91.1
Anthony F Milano
<p><strong>Background: </strong>.-Sinonasal malignancies are rare, aggressive, deadly and challenging tumors to diagnose and treat. Since 2000, age-adjusted incidence rates average less than 1 case per 100,000 per year, male and female combined, in the United States. For the entire cohort, 2000-2017, overall median age-onset was 62.6 years. Carcinoma constitutes over 90% of these upper respiratory cancers and most cases are advanced, more than 72% (regional or distant stage) when the diagnosis is made. Composite mortality at 5 years was 108 excess deaths/1000/year with a mortality ratio of 558%, and 41% of deaths occurred in this time frame. As a consequence, observed median survival was approximately 6 years with 5-year cumulative observed survival (P) and relative survival rates (SR) 53% and 60%. This mortality and survival update study follows the World Health Organization International Classification of Diseases for Oncology-3rd Edition (ICD-O-3)1 topographical identification, coding, labeling and listing of 13,404 patient-cases accessible for analysis in the United States National Cancer Institute's Surveillance, Epidemiology and End Results program (NCI SEER Research Data, 18 Registries), 2000-2017 located in 8 primary anatomical sites: C30.0-Nasal cavity, C30.1-Middle ear, C31.0-Maxillary sinus, C31.1-Ethmoid sinus, C31.2-Frontal sinus, C31.3-Sphenoid sinus, C31.8-Overlapping lesion of accessory sinuses, C31.9-Accessory sinus, NOS.</p><p><strong>Objectives: </strong>.-1) Utilize national population-based SEER registry data for 2000-2017 to update cancer survival and mortality outcomes for 8 ICD-O-3 topographically coded sinonasal primary sites. 2) Discern similarities and contrasts in NCI-SEER case characteristics. 3) Identify current risk pattern outcomes and shifts in United States citizens, 2000-2017.</p><p><strong>Methods: </strong>.-SEER Research Data, 18 Registries, Nov 2019 Sub (2000-2017)2,3 are used to examine the risk consequences of 13,404 patients diagnosed with sinonasal malignancies, 2000-2017, in this retrospective population-based study employing prognostic data stratified by topography, age, sex, race, stage, grade, 2 cohort entry time-periods (2000-06 & 2007-17), and disease-duration to 15 years. General methods and standard double decrement life table methodologies for displaying and converting SEER site-specific annual survival and mortality data to aggregate average annual data units in durational intervals of 0-1, 0-2, 1-2, 2-5, 0-5, 5-10, and 10-15 years are employed. The reader is referred to the "Registrar Staging Assistant (SEER*RSA)" for local-regional-distant Extent of Disease (EOD) sources used in the development of staging descriptions for the Nasal Cavity and Paranasal Sinuses (maxillary and ethmoid sinuses only) and Summary Stage 2018 Coding Manual v2.0 released September 1, 2020. Cancer staging & grading procedural explanations, statistical significance & 95% confidence levels4 are described in previous Jou
背景:......窦道恶性肿瘤是一种罕见、侵袭性强、致命、诊断和治疗难度大的肿瘤。自2000年以来,在美国,经年龄调整后的发病率平均每年每10万名男性和女性中不到1例。在 2000-2017 年的整个队列中,发病年龄的总体中位数为 62.6 岁。在这些上呼吸道癌症中,90% 以上为癌肿,大多数病例在确诊时已属晚期,超过 72%(区域或远处分期)。5 年的综合死亡率为 108 例死亡/1000 例/年,死亡率为 558%,41% 的死亡发生在这一时期。因此,观察到的中位生存期约为 6 年,5 年累计观察生存期(P)和相对生存率(SR)分别为 53% 和 60%。这项死亡率和生存率更新研究采用了世界卫生组织《国际肿瘤疾病分类-第 3 版》(ICD-O-3)1 的地形识别、编码、标签和列表方法,对美国国家癌症研究所的监测、流行病学和最终结果计划(NCI SEER 研究数据,18 个登记处)中 2000-2017 年可获得的 13,404 例患者病例进行了分析,这些病例分布在 8 个主要解剖部位:C30.0-鼻腔、C30.1-中耳、C31.0-下颌窦、C31.1-蝶窦、C31.2-额窦、C31.3-蝶窦、C31.8-附属窦重叠病变、C31.9-附属窦,NOS。目标:.-1)利用 2000-2017 年基于人群的 SEER 登记数据,更新 8 个 ICD-O-3 拓扑编码鼻窦原发部位的癌症生存率和死亡率结果。2) 识别 NCI-SEER 病例特征的相似性和对比性。3) 确定 2000-2017 年美国公民当前的风险模式结果和转变。-在这项基于人群的回顾性研究中,采用了按地形、年龄、性别、种族、分期、分级、2 个队列进入时间段(2000-06 年和 2007-17 年)和病程达 15 年的分层预后数据,对 2000-2017 年诊断为鼻窦恶性肿瘤的 13404 名患者的风险后果进行了研究。采用一般方法和标准双减生命表方法显示 SEER 特定地点的年度存活率和死亡率数据,并将其转换为以 0-1、0-2、1-2、2-5、0-5、5-10 和 10-15 年为持续时间间隔的年均数据单位。读者可参阅 "注册医师分期助手(SEER*RSA)",了解用于制定鼻腔和副鼻窦(仅限上颌窦和乙状窦)分期描述的本地-区域-远处疾病范围(EOD)来源,以及 2020 年 9 月 1 日发布的《2018 年摘要分期编码手册》v2.0。癌症分期和分级的程序解释、统计意义和 95% 置信度4 在之前的《保险医学杂志》文章5,6 和其他出版物7,8 中有所描述。本研究中使用了基于观察到的死亡人数的 95% 水平的泊松置信区间,但为了节省死亡率表格的空间,此处未予显示。结果:......在 SEER 18 登记处中,共有 13,404 例患者(2000-2017 年)可用于分析,其发病率低于每 10 万人 1 例。在这组病例中,共分析了10624名患者的存活率和死亡率。男性占病例的 59.3%,女性占 40.7%。白人占病例的 80.3%,黑人、其他和未知患者占 19.7%。最常见的恶性肿瘤解剖部位是鼻腔(49.7%),最少见的是额窦(1.2%)。从确诊开始,在8个原发部位中,第一年死亡率q从14.3%(C30.0-鼻腔)到30.2%(C31.8-重叠窦)不等,相应的超额死亡率(EDR)分别为118/1000/年和279/1000/年。就单一部位而言,鼻腔的 5 年累积生存率(SR)最高(69.5%),附属窦重叠病变的 5 年累积生存率(SR)最低(47.2%),超额死亡率(EDR)分别为 76/1000/ 年和 169/1000/ 年。结论:......8 个鼻窦癌原发部位的特点是局部阶段的病例比例较低(28%)。由于即使在局部化疗阶段死亡率也很高,因此所有患者的总体预后都很差。鼻窦鼻道癌症的超额死亡率在确诊和治疗后长达 10-15 年持续存在。在 15 年的持续时间内,所有鼻窦部位癌症的超额死亡率仍为 27.6‰/年,累计生存率(SR)持续下降至 43.9%。
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Journal of insurance medicine (New York, N.Y.)
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