首页 > 最新文献

Journal of insurance medicine (New York, N.Y.)最新文献

英文 中文
Prostate cancer. 前列腺癌。
Q3 Medicine Pub Date : 2023-03-21 DOI: 10.1002/0470041102.ch18
R. E. Frank
Prostate cancer is the most common internal cancer in American males. There are many variables that effect prognosis, with the Gleason scoring system being one of the most important factors. There is controversy regarding the ideal treatment in various subsets of prostate cancer patients. Posttreatment prostate specific antigen values have prognostic significance.
前列腺癌是美国男性最常见的内部癌症。影响预后的因素有很多,其中格里森评分系统是最重要的因素之一。对于不同亚群前列腺癌患者的理想治疗方法存在争议。治疗后前列腺特异性抗原值具有预后意义。
{"title":"Prostate cancer.","authors":"R. E. Frank","doi":"10.1002/0470041102.ch18","DOIUrl":"https://doi.org/10.1002/0470041102.ch18","url":null,"abstract":"Prostate cancer is the most common internal cancer in American males. There are many variables that effect prognosis, with the Gleason scoring system being one of the most important factors. There is controversy regarding the ideal treatment in various subsets of prostate cancer patients. Posttreatment prostate specific antigen values have prognostic significance.","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/0470041102.ch18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41641914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lip Cancer: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration A Systematic Review of 19,213 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5). 唇癌:按年龄、性别、种族、分期、分级、队列进入时间和疾病持续时间划分的20年生存率和死亡率比较分析:1973-2014年19,213例诊断病例的系统回顾:(SEER*Stat 8.3.5)。
Q3 Medicine Pub Date : 2023-03-07 DOI: 10.17849/insm-49-4-1-12.1
Anthony F Milano

This report summarizes the incidence, relative frequency distributions and survival & mortality by age, sex, stage and grade, of adult invasive primary cancers of the lip in two entrant time-periods as recorded in the SEER Program of the National Cancer Institute for diagnosis years 1973-2014 (SEER Stat 8.3.5). While the occurrence rates and frequency are low in the United States, they are exceptionally important from a clinical and surgical standpoint because of the morphological and functional changes involved.

本报告总结了1973-2014年美国国家癌症研究所SEER项目诊断年份(SEER Stat 8.3.5)中记录的两个进入期成人侵袭性原发性唇部癌的发病率、相对频率分布、生存率和死亡率,按年龄、性别、分期和分级。虽然美国的发生率和频率较低,但由于涉及形态学和功能改变,从临床和外科的角度来看,它们非常重要。
{"title":"Lip Cancer: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration A Systematic Review of 19,213 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5).","authors":"Anthony F Milano","doi":"10.17849/insm-49-4-1-12.1","DOIUrl":"https://doi.org/10.17849/insm-49-4-1-12.1","url":null,"abstract":"<p><p>This report summarizes the incidence, relative frequency distributions and survival & mortality by age, sex, stage and grade, of adult invasive primary cancers of the lip in two entrant time-periods as recorded in the SEER Program of the National Cancer Institute for diagnosis years 1973-2014 (SEER Stat 8.3.5). While the occurrence rates and frequency are low in the United States, they are exceptionally important from a clinical and surgical standpoint because of the morphological and functional changes involved.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proactive Outreach for At-risk Health Plan Members During COVID-19 Pandemic in New Mexico. 在新墨西哥州COVID-19大流行期间,为高危健康计划成员提供积极外展服务。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-1-10.1
Victoria C Dirmyer, Ingrid Wurpts, Gray Clarke, Lane Evans, Cynthia Al-Aghbary, Kalyani Gopalan, Soyal Momin

Objective: -Explore the impact of proactive outreach to a health plan population during COVID-19 pandemic in New Mexico.

Background: -By March 2020, the 2019 novel coronavirus (COVID-19) was a global pandemic, circulating in more than 114 countries. As more information about virus transmission, symptoms, and comorbidities were reported over time, recommendations for reducing the spread of the virus within communities was provided by leading health organizations like the Centers for Disease Control and Prevention (CDC).

Methods: -Criteria were developed to identify health plan members most at risk for virus complications. Once members were identified, a health plan representative contacted each member to inquire about member needs, questions, and provide them with resources. Members were then tracked for COVID-19 testing results and vaccination status.

Results: -Overall, 50,000+ members received an outreach call (during 8-month timeframe), and 26,000 calls were tracked for member outcomes. Over 50% of the outreach calls were answered by the health plan member. Of the members who were called, 1186 (4.4%) tested positive for COVID-19. Health plan members that could not be reached represented 55% of the positive cases. A chi-square test of the two populations (reached vs unable to reach) showed a significant difference in COVID-19 positive test results (N = 26,663, X2(1) = 16.33, P<0.01).

Conclusions: -Community outreach was related to lower rates of COVID-19. Community connection is important, especially in tumultuous times, and proactive outreach to the community provides an opportunity for information sharing and community bonding.

目的:-探索新墨西哥州在COVID-19大流行期间对健康计划人群进行主动外展的影响。背景:到2020年3月,2019年新型冠状病毒(COVID-19)已成为全球大流行,在114多个国家传播。随着时间的推移,有关病毒传播、症状和合并症的信息越来越多,疾病控制和预防中心(CDC)等主要卫生组织提出了减少病毒在社区内传播的建议。方法:制定标准以确定最有可能发生病毒并发症的健康计划成员。一旦确定了成员,健康计划代表就会联系每个成员,询问成员的需求和问题,并为他们提供资源。然后跟踪成员的COVID-19检测结果和疫苗接种状况。结果:总体而言,50,000多名会员接到了外展电话(在8个月的时间框架内),26,000个电话被跟踪以了解会员的结果。超过50%的外展电话是由健康计划成员接听的。在被传唤的成员中,1186人(4.4%)被检测出新冠病毒阳性。无法接触到的健康计划成员占阳性病例的55%。两组人群(到达与无法到达)的卡方检验显示COVID-19阳性检测结果有显著差异(N = 26,663, X2(1) = 16.33, p)结论:社区外展与较低的COVID-19发病率有关。社区联系很重要,特别是在动荡时期,积极主动地向社区伸出援手为信息共享和社区联系提供了机会。
{"title":"Proactive Outreach for At-risk Health Plan Members During COVID-19 Pandemic in New Mexico.","authors":"Victoria C Dirmyer,&nbsp;Ingrid Wurpts,&nbsp;Gray Clarke,&nbsp;Lane Evans,&nbsp;Cynthia Al-Aghbary,&nbsp;Kalyani Gopalan,&nbsp;Soyal Momin","doi":"10.17849/insm-49-4-1-10.1","DOIUrl":"https://doi.org/10.17849/insm-49-4-1-10.1","url":null,"abstract":"<p><strong>Objective: </strong>-Explore the impact of proactive outreach to a health plan population during COVID-19 pandemic in New Mexico.</p><p><strong>Background: </strong>-By March 2020, the 2019 novel coronavirus (COVID-19) was a global pandemic, circulating in more than 114 countries. As more information about virus transmission, symptoms, and comorbidities were reported over time, recommendations for reducing the spread of the virus within communities was provided by leading health organizations like the Centers for Disease Control and Prevention (CDC).</p><p><strong>Methods: </strong>-Criteria were developed to identify health plan members most at risk for virus complications. Once members were identified, a health plan representative contacted each member to inquire about member needs, questions, and provide them with resources. Members were then tracked for COVID-19 testing results and vaccination status.</p><p><strong>Results: </strong>-Overall, 50,000+ members received an outreach call (during 8-month timeframe), and 26,000 calls were tracked for member outcomes. Over 50% of the outreach calls were answered by the health plan member. Of the members who were called, 1186 (4.4%) tested positive for COVID-19. Health plan members that could not be reached represented 55% of the positive cases. A chi-square test of the two populations (reached vs unable to reach) showed a significant difference in COVID-19 positive test results (N = 26,663, X2(1) = 16.33, P<0.01).</p><p><strong>Conclusions: </strong>-Community outreach was related to lower rates of COVID-19. Community connection is important, especially in tumultuous times, and proactive outreach to the community provides an opportunity for information sharing and community bonding.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9330730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality Statistics in Asthma. 哮喘死亡率统计。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-04-244-249.1
Rodney C Richie

This article summarizes the mortality associated with asthma and was created from a presentation given at the 130th AAIM Annual Meeting.

这篇文章总结了与哮喘相关的死亡率,并根据第130届AAIM年会上的一份报告创建。
{"title":"Mortality Statistics in Asthma.","authors":"Rodney C Richie","doi":"10.17849/insm-49-04-244-249.1","DOIUrl":"https://doi.org/10.17849/insm-49-04-244-249.1","url":null,"abstract":"<p><p>This article summarizes the mortality associated with asthma and was created from a presentation given at the 130th AAIM Annual Meeting.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normal Transaminases in Methamphetamine- and Heroin-Associated Hyperammonemic Encephalopathy. 甲基苯丙胺和海洛因相关性高氨血症脑病的正常转氨酶。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-2-4.1
Vera F Dolan

Detecting undisclosed methamphetamine and heroin abuse is a challenge for life underwriters and medical directors. A common clinical assumption is that if substance abusers experience liver damage, it will be indicated by elevated serum transaminases. The following case suggests that assumption may not be true for heavy substance abusers who consume no or minimal alcohol. This report describes a 44-year-old male with long-term use of inhaled combined methamphetamine and heroin ("speedballs") and minimal alcohol use, whose transaminases remained normal while episodes of acute liver failure and transient hepatic encephalopathy from hyperammonemia were observed. In this case, a fatal motor vehicle accident occurred following the sudden onset of hepatic encephalopathy hours after consuming a "speedball." Normal transaminases may not be proof of a normal healthy liver among methamphetamine and heroin abusers.

检测未公开的甲基苯丙胺和海洛因滥用对寿险保险公司和医疗主管来说是一个挑战。一个常见的临床假设是,如果药物滥用者经历肝损害,它将表明血清转氨酶升高。下面的案例表明,对于不饮酒或少量饮酒的重度药物滥用者来说,这种假设可能不成立。本报告描述了一名44岁男性,长期吸入甲基苯丙胺和海洛因(“速球”)并少量饮酒,其转氨酶保持正常,但观察到急性肝功能衰竭和高氨血症引起的一过性肝性脑病发作。在这个案例中,一个致命的机动车事故发生在肝性脑病的突然发作数小时后,食用“速度球”。在甲基苯丙胺和海洛因滥用者中,正常的转氨酶可能不是肝脏正常健康的证明。
{"title":"Normal Transaminases in Methamphetamine- and Heroin-Associated Hyperammonemic Encephalopathy.","authors":"Vera F Dolan","doi":"10.17849/insm-49-4-2-4.1","DOIUrl":"https://doi.org/10.17849/insm-49-4-2-4.1","url":null,"abstract":"<p><p>Detecting undisclosed methamphetamine and heroin abuse is a challenge for life underwriters and medical directors. A common clinical assumption is that if substance abusers experience liver damage, it will be indicated by elevated serum transaminases. The following case suggests that assumption may not be true for heavy substance abusers who consume no or minimal alcohol. This report describes a 44-year-old male with long-term use of inhaled combined methamphetamine and heroin (\"speedballs\") and minimal alcohol use, whose transaminases remained normal while episodes of acute liver failure and transient hepatic encephalopathy from hyperammonemia were observed. In this case, a fatal motor vehicle accident occurred following the sudden onset of hepatic encephalopathy hours after consuming a \"speedball.\" Normal transaminases may not be proof of a normal healthy liver among methamphetamine and heroin abusers.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical Illness at 40: Still a Thorn in the Medical Director's Side. 40岁时的危重疾病:仍然是医学主任的眼中钉。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-4-3-3.1
Timothy Meagher

Critical illness insurance was introduced 40 years ago. Medical directors continue to be challenged and frustrated with the complexities that critical illness claims offer. This article provides insights into the continued issues and possible solutions.

重病保险是40年前推出的。医疗主管继续受到挑战和沮丧的复杂性,危重疾病索赔提供。本文提供了对持续存在的问题和可能的解决方案的见解。
{"title":"Critical Illness at 40: Still a Thorn in the Medical Director's Side.","authors":"Timothy Meagher","doi":"10.17849/insm-49-4-3-3.1","DOIUrl":"https://doi.org/10.17849/insm-49-4-3-3.1","url":null,"abstract":"<p><p>Critical illness insurance was introduced 40 years ago. Medical directors continue to be challenged and frustrated with the complexities that critical illness claims offer. This article provides insights into the continued issues and possible solutions.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morbidity and Mortality Associated with Chronic Obstructive Pulmonary Disease (COPD). 慢性阻塞性肺疾病(COPD)的发病率和死亡率。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-04-230-243.1
Rodney C Richie

This article summarizes the morbidity and mortality associated with COPD and was created from a presentation given at the 130th AAIM Annual Meeting. The author reviews what most medical directors already know about COPD, but with particular attention paid to the Pulmonary Function Tests dealing with spirometry. Underwriters and medical directors need to understand the three basic measurements of spirometry (FVC, FEV1, and FEF25-75), as well as the significance of the FEV1/FVC ratio, in establishing an applicant as having an obstructive or restrictive impairment.

这篇文章总结了COPD相关的发病率和死亡率,是根据第130届AAIM年会上的一份报告编写的。作者回顾了大多数医学主任已经知道的关于慢性阻塞性肺病,但特别关注肺功能测试处理肺活量测定。承保人和医疗主管需要了解肺活量测定法的三个基本测量值(FVC、FEV1和FEF25-75),以及FEV1/FVC比值在确定申请人是否患有阻塞性或限制性损伤方面的重要性。
{"title":"Morbidity and Mortality Associated with Chronic Obstructive Pulmonary Disease (COPD).","authors":"Rodney C Richie","doi":"10.17849/insm-49-04-230-243.1","DOIUrl":"https://doi.org/10.17849/insm-49-04-230-243.1","url":null,"abstract":"<p><p>This article summarizes the morbidity and mortality associated with COPD and was created from a presentation given at the 130th AAIM Annual Meeting. The author reviews what most medical directors already know about COPD, but with particular attention paid to the Pulmonary Function Tests dealing with spirometry. Underwriters and medical directors need to understand the three basic measurements of spirometry (FVC, FEV1, and FEF25-75), as well as the significance of the FEV1/FVC ratio, in establishing an applicant as having an obstructive or restrictive impairment.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JIM Reading List. 吉姆阅读清单。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.17849/insm-49-04-254-258.1
{"title":"JIM Reading List.","authors":"","doi":"10.17849/insm-49-04-254-258.1","DOIUrl":"https://doi.org/10.17849/insm-49-04-254-258.1","url":null,"abstract":"","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Liver Function Tests with Mortality in an Insurance Applicant Population. 保险申请人人群中肝功能检测与死亡率的关系
Q3 Medicine Pub Date : 2022-07-01 DOI: 10.17849/insm-49-3-172-182.1
Steven J Rigatti, Robert Stout

Objectives: -Determine the relationship between liver function test (LFT) results (GGT, alkaline phosphatase, AST, ALT and albumin) and all-cause mortality in life insurance applicants.

Method: -By use of the Social Security Master Death File, mortality was examined in 15,272,955 insurance applicants for whom blood samples were submitted to the Clinical Reference Laboratory. There were 268,593 deaths observed in this study population, after an average follow-up time of 10.9 years. Results were stratified by sex and by age less/greater than 60, creating 4 groups. Liver function test values were grouped using percentiles of their distribution within these age/ sex groups - so as to update the results generated in prior publications. Additional models were fit using different exclusions and percentile groups within single year age groups. Also, LFTs were treated as continuous variables and included in Cox models with age and smoking status.

Results: -Using the risk of the middle 50% of the population by distribution as a reference, relative mortality observed for GGT and alkaline phosphatase was linear with a steep slope from very low to high values. AST showed a J-shaped association with mortality. ALT showed a low-magnitude inverse correlation with mortality. Albumin demonstrated a higher-magnitude inverse correlation with mortality, especially at values below the median. The overall risk associated with LFTs was durable over at least 10 years of follow-up.

Conclusion: -Liver function tests show a strong and durable correlation to mortality in a large group of insurance applicants. The durability over time suggests that even older values of LFTs found in medical records could be of use in mortality risk prediction.

目的:确定寿险申请人肝功能检查(LFT)结果(GGT、碱性磷酸酶、AST、ALT和白蛋白)与全因死亡率之间的关系。方法:-通过使用社会保障总死亡档案,对15,272,955名投保人的死亡率进行了检查,他们的血液样本被提交给临床参考实验室。在平均10.9年的随访时间后,在该研究人群中观察到268,593例死亡。结果按性别、60岁以下/ 60岁以上年龄分层,分为4组。在这些年龄/性别组中使用其分布的百分位数对肝功能测试值进行分组,以便更新先前出版物中产生的结果。其他模型在单年年龄组中使用不同的排除和百分位数组进行拟合。此外,LFTs被视为连续变量,并与年龄和吸烟状况一起纳入Cox模型。结果:-以分布人群中中间50%的风险为参照,GGT和碱性磷酸酶的相对死亡率呈线性关系,从非常低的值到高的值呈陡斜率。AST与死亡率呈j型相关。ALT与死亡率呈低幅度负相关。白蛋白与死亡率呈较高的负相关,特别是在低于中位数的值时。与LFTs相关的总体风险在至少10年的随访中持续存在。结论:-肝功能测试显示,在一大群保险申请人中,肝功能测试与死亡率有很强且持久的相关性。随着时间的推移,即使是在医疗记录中发现的更古老的LFTs值也可能用于死亡率风险预测。
{"title":"Association of Liver Function Tests with Mortality in an Insurance Applicant Population.","authors":"Steven J Rigatti,&nbsp;Robert Stout","doi":"10.17849/insm-49-3-172-182.1","DOIUrl":"https://doi.org/10.17849/insm-49-3-172-182.1","url":null,"abstract":"<p><strong>Objectives: </strong>-Determine the relationship between liver function test (LFT) results (GGT, alkaline phosphatase, AST, ALT and albumin) and all-cause mortality in life insurance applicants.</p><p><strong>Method: </strong>-By use of the Social Security Master Death File, mortality was examined in 15,272,955 insurance applicants for whom blood samples were submitted to the Clinical Reference Laboratory. There were 268,593 deaths observed in this study population, after an average follow-up time of 10.9 years. Results were stratified by sex and by age less/greater than 60, creating 4 groups. Liver function test values were grouped using percentiles of their distribution within these age/ sex groups - so as to update the results generated in prior publications. Additional models were fit using different exclusions and percentile groups within single year age groups. Also, LFTs were treated as continuous variables and included in Cox models with age and smoking status.</p><p><strong>Results: </strong>-Using the risk of the middle 50% of the population by distribution as a reference, relative mortality observed for GGT and alkaline phosphatase was linear with a steep slope from very low to high values. AST showed a J-shaped association with mortality. ALT showed a low-magnitude inverse correlation with mortality. Albumin demonstrated a higher-magnitude inverse correlation with mortality, especially at values below the median. The overall risk associated with LFTs was durable over at least 10 years of follow-up.</p><p><strong>Conclusion: </strong>-Liver function tests show a strong and durable correlation to mortality in a large group of insurance applicants. The durability over time suggests that even older values of LFTs found in medical records could be of use in mortality risk prediction.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40467514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancers of the Oral Cavity and Pharynx: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration: A Systematic Review of 218,066 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5). 口腔癌和咽癌:按年龄、性别、种族、分期、分级、队列入组时间和病程划分的20年生存率和死亡率比较分析:1973-2014年218066例诊断病例的系统评价:(SEER*Stat 8.3.5)。
Q3 Medicine Pub Date : 2022-07-01 DOI: 10.17849/insm-49-3-147-171.1
Anthony F Milano

This article summarizes the results of a retrospective population-based cohort study using the statistical database of SEER*Stat 8.3.54 (produced 3/5/2018 for diagnosis years 1973-2014) to assess, determine, compare, and summarize the occurrence, long-term survival, and mortality indices of 218,066 patients with oral cavity and pharynx cancers by age, sex, race, stage, grade, and disease duration.

本文利用SEER*Stat 8.3.54统计数据库(3/5/2018,诊断年为1973-2014年)对218066例口腔癌和咽喉癌患者的年龄、性别、种族、分期、分级、病程进行回顾性人群队列研究,评估、确定、比较和总结其发生、长期生存和死亡指标。
{"title":"Cancers of the Oral Cavity and Pharynx: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration: A Systematic Review of 218,066 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5).","authors":"Anthony F Milano","doi":"10.17849/insm-49-3-147-171.1","DOIUrl":"https://doi.org/10.17849/insm-49-3-147-171.1","url":null,"abstract":"<p><p>This article summarizes the results of a retrospective population-based cohort study using the statistical database of SEER*Stat 8.3.54 (produced 3/5/2018 for diagnosis years 1973-2014) to assess, determine, compare, and summarize the occurrence, long-term survival, and mortality indices of 218,066 patients with oral cavity and pharynx cancers by age, sex, race, stage, grade, and disease duration.</p>","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40467513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of insurance medicine (New York, N.Y.)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1