Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594958
S.S. Han, B. Dardzinski, C. Sotak
The purpose of this study was to investigate methods for reconciling differences between tumor oxygenation measurements performed using /sup 19/F NMR spectroscopy and imaging of sequestered PFC's. In vivo data from RIF-1 tumor bearing C/sub 3/H mice were acquired using /sup 19/F NMR spectroscopy and imaging, and the imaging data were analyzed via three different methods: (1) average of the T/sub 1/ map; (2) weighted average of the T/sub 1/ map which compensated for the spin density (M/sub 0/); and (3) region of interest (ROI) analysis of the tumor region. It was shown that compensating for M/sub 0/ in the imaging maps allowed correction of much of the discrepancy between tumor oxygenation values that were calculated from imaging and spectroscopic data.
{"title":"Reconciling differences between tumor oxygenation measurements performed using /sup 19/F NMR spectroscopy and imaging of perfluorocarbon (PFC) emulsions","authors":"S.S. Han, B. Dardzinski, C. Sotak","doi":"10.1109/NEBC.1997.594958","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594958","url":null,"abstract":"The purpose of this study was to investigate methods for reconciling differences between tumor oxygenation measurements performed using /sup 19/F NMR spectroscopy and imaging of sequestered PFC's. In vivo data from RIF-1 tumor bearing C/sub 3/H mice were acquired using /sup 19/F NMR spectroscopy and imaging, and the imaging data were analyzed via three different methods: (1) average of the T/sub 1/ map; (2) weighted average of the T/sub 1/ map which compensated for the spin density (M/sub 0/); and (3) region of interest (ROI) analysis of the tumor region. It was shown that compensating for M/sub 0/ in the imaging maps allowed correction of much of the discrepancy between tumor oxygenation values that were calculated from imaging and spectroscopic data.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"59 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120879901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594964
L.A. Santiago, D. Tucker
This work is being done to enable the creation of a proven method of predicting specific conformations of hydroxyapatite for the needs of hard and soft tissue replacement. Specific conformations of hydroxyapatite are needed in order to replicate the many different types of hydroxyapatites found in different tissues around the body, including bone and cartilage. Through the establishment of a known method of creating specific conformations of hydroxyapatite matching those found in the body, an in vitro matrix could then be developed for the replacement of lost or damaged tissues throughout the body.
{"title":"Predictable hydroxyapatite conformation","authors":"L.A. Santiago, D. Tucker","doi":"10.1109/NEBC.1997.594964","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594964","url":null,"abstract":"This work is being done to enable the creation of a proven method of predicting specific conformations of hydroxyapatite for the needs of hard and soft tissue replacement. Specific conformations of hydroxyapatite are needed in order to replicate the many different types of hydroxyapatites found in different tissues around the body, including bone and cartilage. Through the establishment of a known method of creating specific conformations of hydroxyapatite matching those found in the body, an in vitro matrix could then be developed for the replacement of lost or damaged tissues throughout the body.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"41 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125914932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594968
M. Zullow, S. Reisman
A pilot study was performed to test the theory that manual medicine techniques known as the CV4 (compression of fourth cerebral ventricle) maneuver and a Sacra/Illiac Bridge Hold combination increase parasympathetic activity. Autonomic activity was measured in this study by computing heart rate variability. Results indicated an increase in parasympathetic activity as a result of the CV4 maneuver and Sacral Holds.
{"title":"Measurement of autonomic function during craniosacral manipulation using heart rate variability","authors":"M. Zullow, S. Reisman","doi":"10.1109/NEBC.1997.594968","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594968","url":null,"abstract":"A pilot study was performed to test the theory that manual medicine techniques known as the CV4 (compression of fourth cerebral ventricle) maneuver and a Sacra/Illiac Bridge Hold combination increase parasympathetic activity. Autonomic activity was measured in this study by computing heart rate variability. Results indicated an increase in parasympathetic activity as a result of the CV4 maneuver and Sacral Holds.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"7563 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128014121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594948
J. Sommers, R. Gaumond
A promising coil geometry for focal stimulation of neurons through magnetic induction is the quad-square coil. This configuration utilizes four 90/spl deg/ corners at the center to produce large values of dE/sub x//dx (considered the activating function in neural stimulation). The values of dE/sub x//dx produced by the center of the coil are limited by the coil dimensions and coil spacing. A closed form solution of the limiting function in terms of coil dimension, spacing, and stimulating depth is presented and the relationship between dE/sub x//dx and spacing is graphically shown.
{"title":"Spacing analysis of a focal magnetic stimulating coil","authors":"J. Sommers, R. Gaumond","doi":"10.1109/NEBC.1997.594948","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594948","url":null,"abstract":"A promising coil geometry for focal stimulation of neurons through magnetic induction is the quad-square coil. This configuration utilizes four 90/spl deg/ corners at the center to produce large values of dE/sub x//dx (considered the activating function in neural stimulation). The values of dE/sub x//dx produced by the center of the coil are limited by the coil dimensions and coil spacing. A closed form solution of the limiting function in terms of coil dimension, spacing, and stimulating depth is presented and the relationship between dE/sub x//dx and spacing is graphically shown.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116783356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594953
W. Yuan, J. Semmlow, T. Alvarez, P. Munoz
According to the dual-mode theory, the two different dynamic components seen in the step response of disparity vergence eye movements are under separate control mechanisms. The initial, fast rising component is controlled by an open loop, preprogrammed system while the later, slow component is feedback controlled. The ability to separate the two components, or to isolate the initial component, is critical to the study of both control systems. To approach this goal, a simple open-loop control model, containing four independently adjustable parameters, was designed to simulate the disparity vergence movement. This model provided a substantial simplification of the control system, yet demonstrated remarkable accuracy in its ability to simulate the dynamic details of the initial component vergence response.
{"title":"A minimal model to simulate dynamics of initial vergence component","authors":"W. Yuan, J. Semmlow, T. Alvarez, P. Munoz","doi":"10.1109/NEBC.1997.594953","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594953","url":null,"abstract":"According to the dual-mode theory, the two different dynamic components seen in the step response of disparity vergence eye movements are under separate control mechanisms. The initial, fast rising component is controlled by an open loop, preprogrammed system while the later, slow component is feedback controlled. The ability to separate the two components, or to isolate the initial component, is critical to the study of both control systems. To approach this goal, a simple open-loop control model, containing four independently adjustable parameters, was designed to simulate the disparity vergence movement. This model provided a substantial simplification of the control system, yet demonstrated remarkable accuracy in its ability to simulate the dynamic details of the initial component vergence response.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127171906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594957
K. M. Lahti, C. Ferris, C. Sotak, J. A. King
Human studies utilizing functional magnetic resonance imaging (fMRI) have advanced our understanding of the regional and functional interplay between populations of neurons serving sensory, integrative and motor functions. Although animal studies allow greater flexibility in experimental design, performing such studies in animals has been difficult, since they are typically anesthetized in order to minimize motion artifacts. In this a study a novel restriction device is used to minimize the interfering motion artifacts from head and body movements. Furthermore, preliminary BOLD fMRI experiment with an electrically evoked cortical brain activation, is performed in fully conscious animal. Signal changes are measured without the use of contrast agents.
{"title":"Functional MRI in conscious rats using electrical stimulation of a hind paw","authors":"K. M. Lahti, C. Ferris, C. Sotak, J. A. King","doi":"10.1109/NEBC.1997.594957","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594957","url":null,"abstract":"Human studies utilizing functional magnetic resonance imaging (fMRI) have advanced our understanding of the regional and functional interplay between populations of neurons serving sensory, integrative and motor functions. Although animal studies allow greater flexibility in experimental design, performing such studies in animals has been difficult, since they are typically anesthetized in order to minimize motion artifacts. In this a study a novel restriction device is used to minimize the interfering motion artifacts from head and body movements. Furthermore, preliminary BOLD fMRI experiment with an electrically evoked cortical brain activation, is performed in fully conscious animal. Signal changes are measured without the use of contrast agents.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130994581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594962
R.K. Miles, G. A. Fitch, J. Olivier, J. Pallotta, J. Raja, R. A. Petrie, J. LaCourse
A graphical neurofeedback interface is described which is employed in the non-pharmacological intervention in Attention Deficit/Attention Deficit Hyperactivity Disorder (ADD/ADHD). The interface is used in conjunction with the New England Neurobehavioral (NE Neuro) CorTekScan electroencephalographic amplifier to administer neurofeedback to patients who suffer from ADD/ADHD.
{"title":"Graphical neurofeedback interface for the non-pharmacological intervention in attention deficit/attention deficit hyperactivity disorder","authors":"R.K. Miles, G. A. Fitch, J. Olivier, J. Pallotta, J. Raja, R. A. Petrie, J. LaCourse","doi":"10.1109/NEBC.1997.594962","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594962","url":null,"abstract":"A graphical neurofeedback interface is described which is employed in the non-pharmacological intervention in Attention Deficit/Attention Deficit Hyperactivity Disorder (ADD/ADHD). The interface is used in conjunction with the New England Neurobehavioral (NE Neuro) CorTekScan electroencephalographic amplifier to administer neurofeedback to patients who suffer from ADD/ADHD.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115297574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594955
R.K. Miles, L. Gardner, R. Croce, J. Miller, J. Lacourse
An empirically derived Rehabilitation Work Conditioning Protocol (RWCP) has been found to significantly reduce the recurrence of upper quadrant cumulative trauma disorders (CTD's) among high risk workers (OSHA Criteria, musculoskeletal disorders, MSD) and dramatically reduce Workers' Compensation Costs at a manufacturing facility. A controlled study to quantify the changes occurring in the worker's physiology as a consequence of the RWCP is proposed, the findings to be configured into a screening protocol to predict a predisposition to upper quadrant cumulative disorders.
{"title":"Minimum strength criteria as a predictor of predisposition to upper quadrant cumulative trauma disorders among high risk workers","authors":"R.K. Miles, L. Gardner, R. Croce, J. Miller, J. Lacourse","doi":"10.1109/NEBC.1997.594955","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594955","url":null,"abstract":"An empirically derived Rehabilitation Work Conditioning Protocol (RWCP) has been found to significantly reduce the recurrence of upper quadrant cumulative trauma disorders (CTD's) among high risk workers (OSHA Criteria, musculoskeletal disorders, MSD) and dramatically reduce Workers' Compensation Costs at a manufacturing facility. A controlled study to quantify the changes occurring in the worker's physiology as a consequence of the RWCP is proposed, the findings to be configured into a screening protocol to predict a predisposition to upper quadrant cumulative disorders.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115870328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594941
P. Nketia, S. Reisman
The present study investigated the effects of stress and relaxation on peripheral blood volume. Venous and arterial blood volume, and temperature of the fingertips were measured by photoplethysmograph and thermistor, respectively. The mean of the peak cross correlation between the blood volume and the temperature of the fingertips of the nine cases studied was 0.9236/spl plusmn/0.0408. The finger temperature closely followed that of the finger blood volume but at a slower rate. The blood volume and the temperature of the fingertip increased during eyes closed relaxation, but decreased during stressful state. Changes in venous blood volume (temperature), corresponded to changes in the amplitude of the arterial blood volume. Thus, during relaxation the finger arterioles were vasodilated, and during stress they were vasoconstricted.
{"title":"The relationship between thermoregulatory and haemodynamic responses of the skin to relaxation and stress","authors":"P. Nketia, S. Reisman","doi":"10.1109/NEBC.1997.594941","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594941","url":null,"abstract":"The present study investigated the effects of stress and relaxation on peripheral blood volume. Venous and arterial blood volume, and temperature of the fingertips were measured by photoplethysmograph and thermistor, respectively. The mean of the peak cross correlation between the blood volume and the temperature of the fingertips of the nine cases studied was 0.9236/spl plusmn/0.0408. The finger temperature closely followed that of the finger blood volume but at a slower rate. The blood volume and the temperature of the fingertip increased during eyes closed relaxation, but decreased during stressful state. Changes in venous blood volume (temperature), corresponded to changes in the amplitude of the arterial blood volume. Thus, during relaxation the finger arterioles were vasodilated, and during stress they were vasoconstricted.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124050291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-05-21DOI: 10.1109/NEBC.1997.594933
A. Browne, T. Nelson, R. Northrop
It has long been known that certain organic molecules in solution, e.g. glucose, possess the property of optical activity, rotating the E vector of linearly-polarized light passed through the solution. A Gilham-based polarimeter uses crossed polarizers and E vector modulation to measure the amount of rotation of polarized light caused by a solution of a known path length. In the past, such systems have required the use of an expensive Faraday rotator and a high-voltage photomultiplier tube (PMT) to obtain resolutions down to the microdegree range. We have developed a modified low-cost Gilham polarimeter with microdegree resolution using a coil wound around the solution-under-test instead of a Faraday rotator, and a silicon photo-diode instead of a PMT.
{"title":"Microdegree polarimetric measurement of glucose concentrations for biotechnology applications","authors":"A. Browne, T. Nelson, R. Northrop","doi":"10.1109/NEBC.1997.594933","DOIUrl":"https://doi.org/10.1109/NEBC.1997.594933","url":null,"abstract":"It has long been known that certain organic molecules in solution, e.g. glucose, possess the property of optical activity, rotating the E vector of linearly-polarized light passed through the solution. A Gilham-based polarimeter uses crossed polarizers and E vector modulation to measure the amount of rotation of polarized light caused by a solution of a known path length. In the past, such systems have required the use of an expensive Faraday rotator and a high-voltage photomultiplier tube (PMT) to obtain resolutions down to the microdegree range. We have developed a modified low-cost Gilham polarimeter with microdegree resolution using a coil wound around the solution-under-test instead of a Faraday rotator, and a silicon photo-diode instead of a PMT.","PeriodicalId":393788,"journal":{"name":"Proceedings of the IEEE 23rd Northeast Bioengineering Conference","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124063361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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