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Enumeration of Ki67 proliferation index by an algorithm-based digital image analysis in breast carcinoma 基于算法的乳腺癌数字图像分析中Ki67增殖指数的计数
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2025.07.008
Ankit Dhaka , Jeevantika Rana , Brajesh Singh , Manoj Gopal Madakshira

Background

Ki67 is a prognostic factor in breast carcinoma (BC). We evaluate algorithm-based digital image analysis for Ki67 proliferation index (KPI).

Methods

A retrospective study was conducted on 81 BC cases. KPI (by eyeballing, EB) and tubule scores were obtained from records. A region of interest within the hotspot on the scanned slide was annotated and analysed using ImageJ (Reference standard) and Optrascan algorithm (OA). Statistical analysis included Pearson correlation (PC) included Pearson Correlation (PC) and Bland - Altman plots (BAP).

Results

EB and OA correlated with ImageJ (p < 0.001). OA had a stronger correlation (r: 0.9913) than EB. BAP revealed larger bias with EB (bias: 1.309) than OA. EB showed significant bias in tumours with >10% tubule formation (bias: 7.268) compared with OA.

Conclusion

OA is a reasonable alternative for KPI. EB tends to overestimate in solid tumours and underestimate in differentiated tumours. OA overestimates with increased nuclear pleomorphism and underestimates in increased intra-tumoural lymphocytes or fibroblasts.
背景:ki67是乳腺癌(BC)的预后因素。我们评估基于算法的数字图像分析Ki67增殖指数(KPI)。方法对81例BC患者进行回顾性分析。从记录中获得KPI (by eyeballing, EB)和小管评分。使用ImageJ(参考标准)和Optrascan算法(OA)对扫描切片热点内的感兴趣区域进行注释和分析。统计分析包括Pearson correlation (PC)和Bland - Altman plots (BAP)。结果b、OA与ImageJ相关(p < 0.001)。OA与EB的相关性较强(r: 0.9913)。BAP对EB的偏倚比OA更大(偏倚:1.309)。与OA相比,EB在小管形成>;10%的肿瘤中显示出显著的偏倚(偏倚:7.268)。结论oa是KPI的合理替代方案。EB在实体瘤中倾向于高估,在分化瘤中倾向于低估。OA过高估计核多形性增加,低估肿瘤内淋巴细胞或成纤维细胞增加。
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引用次数: 0
Large urinary bladder leiomyoma mimicking malignancy: Using diffusion-weighted imaging as a problem solving tool 模拟恶性肿瘤的大膀胱平滑肌瘤:使用扩散加权成像作为解决问题的工具
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2023.06.004
Pooja Pande , Satyendra N. Singh , M.V. Manikandan
Benign tumors of the urinary bladder are rare and while leiomyomas are the most common type of benign mesenchymal tumors of the bladder, their incidence is low, and most of these tumors are small and asymptomatic. We present a rare case of a large symptomatic urinary bladder leiomyoma in a young female patient referred to a tertiary cancer hospital for management after a suspicion for malignant involvement was raised on initial evaluation, and subsequently, a magnetic resonance imaging was performed. Diffusion-weighted imaging was used as a problem-solving tool to differentiate the tumor from a more common malignant pathology arising from the urinary bladder.
膀胱良性肿瘤是罕见的,而平滑肌瘤是膀胱良性间质肿瘤中最常见的类型,其发病率较低,且大多数肿瘤小且无症状。我们报告一例罕见的有症状的大膀胱平滑肌瘤的年轻女性患者,在最初的评估中怀疑恶性累及后,被转介到三级肿瘤医院进行治疗,随后进行了磁共振成像。弥散加权成像被用作解决问题的工具,以区分肿瘤与来自膀胱的更常见的恶性病理。
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引用次数: 0
Artificial intelligence in dermatology: The shifting paradigms 皮肤病学中的人工智能:转变的范例
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2025.08.016
Biju Vasudevan , Debdeep Mitra , Venus Deshwal
Artificial intelligence (AI) is revolutionizing dermatological practice, fundamentally transforming diagnostic methodologies, treatment approaches, and patient care delivery systems. This perspective examines the current landscape of AI integration in dermatology, with particular emphasis on the Indian healthcare context. The rapid advancement of deep learning algorithms, particularly convolutional neural networks (CNNs), has achieved diagnostic accuracies comparable to board-certified dermatologists in skin cancer detection, with sensitivities reaching 87% and specificities of 77% across various conditions.
Current applications demonstrate significant promise in conditions ranging from melanoma detection to inflammatory dermatoses, with AI-powered tools showing superior performance in lesion counting and severity assessment compared to manual evaluation. However, challenges persist, including dataset bias, particularly underrepresentation of darker skin tones, regulatory uncertainties, and the need for comprehensive training programs.
Looking forward, the roadmap for AI in Indian dermatology requires strategic curriculum reform, incorporating AI literacy into residency training, development of culturally diverse datasets, and establishment of robust validation frameworks. The rise of vision-language models combined with collaborative learning presents a unique chance to make dermatological knowledge more accessible, especially in areas with limited resources. This transformation demands adaptive strategies from practicing dermatologists, emphasizing continuous learning, ethical AI implementation, and collaborative approaches to technology integration.
The future of dermatology lies in augmented intelligence, where AI serves as a powerful ally rather than a replacement, enhancing diagnostic precision and expanding access to specialized care across India's diverse healthcare landscape.
人工智能(AI)正在彻底改变皮肤科实践,从根本上改变诊断方法、治疗方法和患者护理提供系统。这一观点考察了人工智能在皮肤科整合的现状,特别强调了印度的医疗保健背景。深度学习算法的快速发展,特别是卷积神经网络(cnn),在皮肤癌检测方面已经实现了与委员会认证的皮肤科医生相当的诊断准确性,在各种条件下的敏感性达到87%,特异性达到77%。目前,人工智能工具在从黑色素瘤检测到炎症性皮肤病等方面的应用显示出了巨大的前景,与人工评估相比,人工智能工具在病变计数和严重程度评估方面表现出了卓越的性能。然而,挑战仍然存在,包括数据集偏差,特别是深色肤色的代表性不足,监管不确定性以及对综合培训计划的需求。展望未来,印度皮肤病学的人工智能路线图需要战略性的课程改革,将人工智能知识纳入住院医师培训,开发多元文化的数据集,并建立强大的验证框架。视觉语言模型与协作学习相结合的兴起提供了一个独特的机会,使皮肤病学知识更容易获得,特别是在资源有限的地区。这种转变需要皮肤科医生的适应性策略,强调持续学习、合乎道德的人工智能实施以及技术集成的协作方法。皮肤科的未来在于增强智能,人工智能将成为强大的盟友,而不是替代品,提高诊断精度,并在印度多样化的医疗保健领域扩大专业护理的可及性。
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引用次数: 0
Beyond algorithms: Ethical implications of AI in healthcare 超越算法:人工智能在医疗保健中的伦理影响
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2024.10.014
Rajiv Kumar Pathni
In the recent years, the abilities of artificial intelligence (AI) to augment those of clinicians have been repeatedly and emphatically demonstrated in many medical domains. However, the current state and nature of the technology have raised several concerns about its safety and ethicality. World Health Organization (WHO) has cautioned about the need to demonstrate evidence-based benefits before AI services are offered to patients as they may come with long-term risks. While AI brings immense possibilities, it is essential to address these ethical challenges to ensure its safe, reliable, fair, and trustworthy application in healthcare. This paper explores the challenges for AI in healthcare and discusses its ethical implications using the framework of the four core principles of modern bioethics.
近年来,人工智能(AI)增强临床医生的能力在许多医学领域得到了反复和强调的证明。然而,这项技术的现状和性质引发了人们对其安全性和伦理性的担忧。世界卫生组织(世卫组织)警告说,在向患者提供人工智能服务之前,有必要证明有证据支持的益处,因为人工智能服务可能会带来长期风险。虽然人工智能带来了巨大的可能性,但必须解决这些道德挑战,以确保其在医疗保健领域的安全、可靠、公平和值得信赖的应用。本文探讨了人工智能在医疗保健中的挑战,并利用现代生物伦理学的四个核心原则的框架讨论了其伦理含义。
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引用次数: 0
The role of virtual reality in management of complex congenital heart diseases in comparison to conventional cardiac computed tomography scan 与传统心脏计算机断层扫描相比,虚拟现实技术在复杂先天性心脏病治疗中的作用
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2025.05.015
Nikhil Tiwari , Arvind Mishra , H. Ravi Ramamurthy , Gorav Sharma , B. Dhanalakshmi , Somali Pattanayak , Alok Kumar , Saajan Joshi

Background

Virtual reality (VR) image reconstruction enables the computer-assisted conversion of two-dimensional imaging data into virtual “models” or replicas. This helps reconstruct patient-specific virtual three-dimensional (3D) cardiac models in complex congenital heart diseases (CHD) to better understand the anomaly and surgical decision-making. The study aimed to evaluate the role of VR by creating patient-specific cardiac VR images from high-resolution imaging data of computed tomography (CT) angiography in such patients.

Methods

Patients with complex CHD with a dilemma in surgical management plan after initial evaluation with echocardiography and conventional cardiac CT scans were included for VR cardiac structural reconstruction. All cases were reviewed by the same team, and decisions before VR and after VR were grouped as either “corrective surgery” or “no surgery or medical management”. Agreement in terms of therapeutic decision between the pre-VR and post-VR was analyzed using Cohen's kappa test.

Results

Out of 754 patients diagnosed to have CHD, 413 (54.7%) patients had a clear surgical plan. 146 (19.3%) underwent cardiac catheterization-based intervention procedures while 185 (24.5%) required only medical follow-up. Ten patients (1.3%) had a management dilemma and were included in the study. The commonest indication was to assess the routability of the aorta to the left ventricle. There was an agreement between the pre-VR and post-VR management decisions for three patients (k = −0.21, 95% CI = −0.60, 0.18).

Conclusions

VR reconstruction in CHD is useful in a selected group of patients to improve surgical planning and outcomes in pediatric cardiac surgery.
虚拟现实(VR)图像重建使计算机辅助将二维成像数据转换为虚拟“模型”或复制品。这有助于在复杂先天性心脏病(CHD)中重建患者特异性的虚拟三维(3D)心脏模型,以更好地了解异常和手术决策。该研究旨在通过利用此类患者的计算机断层扫描(CT)血管造影的高分辨率成像数据创建患者特异性心脏VR图像来评估VR的作用。方法对经超声心动图和常规心脏CT扫描初步评估、手术方案进退两难的复杂冠心病患者进行VR心脏结构重建。所有病例均由同一小组审查,虚拟现实前后的决定分为“矫正手术”或“不手术或医疗管理”。采用Cohen’s kappa检验分析vr前和vr后治疗决策的一致性。结果754例冠心病患者中,413例(54.7%)有明确的手术计划。146例(19.3%)接受了基于心导管的干预程序,185例(24.5%)只需要医学随访。10例患者(1.3%)出现管理困境,纳入研究。最常见的适应症是评估主动脉到左心室的可达性。三名患者的vr前和vr后管理决策一致(k = - 0.21, 95% CI = - 0.60, 0.18)。结论svr重建在冠心病患者中有一定的应用价值,有助于改善小儿心脏手术的手术计划和预后。
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引用次数: 0
Health technology assessment for mental health in India 印度心理健康卫生技术评估
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2024.11.010
Kaushik Chatterjee , Ankit Dangi , Vinay Singh Chauhan
Health technology assessment (HTA) is a method of systematically assessing various aspects of a new or available health technology regarding its implementation. HTA can generate evidence regarding the cost effectiveness among existing similar health technology interventions as well. This is relevant in current times when healthcare costs are rising and health inequity is prominent. Mental health care is widely neglected, and globally, resource allocation for mental health is a miniscule part of total health expenditure. HTA in mental health can provide scientifically valid information to guide policy decisions for rational healthcare resource allocation. In India, although HTA has been partly institutionalised, inclusion of mental health–related issues for HTA has lagged. In this short review, we briefly survey the state of HTA in India from a mental health perspective. We have highlighted possible areas that might benefit from HTA process in the field of mental health in India.
卫生技术评估(HTA)是一种系统地评估一种新的或现有的卫生技术在实施方面的各个方面的方法。HTA还可以提供有关现有类似卫生技术干预措施成本效益的证据。这在当前医疗成本不断上升、卫生不平等现象突出的时代具有重要意义。精神卫生保健被广泛忽视,在全球范围内,用于精神卫生的资源分配只占卫生总支出的很小一部分。心理健康HTA可以为决策提供科学有效的信息,指导卫生资源的合理配置。在印度,尽管HTA已部分制度化,但将心理健康相关问题纳入HTA的工作滞后。在这篇简短的综述中,我们从心理健康的角度简要调查了印度的HTA状况。我们强调了在印度精神卫生领域可能受益于HTA进程的领域。
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引用次数: 0
EDU_VACCINE app: Mobile application for public health students and health educators EDU_VACCINE 应用程序:面向公共卫生专业学生和卫生教育工作者的移动应用程序
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2024.06.002
Mahsa Khodayarian , Arezoo Dehghani , Hossein Fallahzadeh , Elahe Nafari

Background

One of the valuable tools in virtual education is mobile phone-based educational applications. The present study aims to design and evaluate the vaccination training program through a mobile phone application for the internship of public health students in 2022.

Methods

The current developmental-applied study was carried out among 30 female undergraduate public health students using census sampling method. The information needs and technical capabilities of the program were first determined. A skill-testing station test was taken, and the scores were recorded. The designed application was given to the students, and they were given one month to use it. After that, the same stationary test was taken again, and the scores were compared with those of the first test. Then, the level of user satisfaction with the vaccination training program was collected and analyzed using the fifth version of the user interaction satisfaction (QUIS) questionnaire. The collected data were analyzed by SPSS software version 25 and the Wilcoxon test with a significance level of 0.05.

Results

The students’ average performance scores in vaccination skills increased from 17.56 ± 6.24 to 60.4 ± 2.15 after using the EDU_VACCINE application (p < 0.05). The average overall satisfaction score of the application was 117.86 ± 10.76 (p < 0.05).

Conclusion

According to the results, the average scores related to the vaccination performance of the students as well as the satisfaction of the EDU_VACCINE application are at a high level. Respectively, ‘ease of working with the application’ and its being ‘offline’ garnered the highest level of satisfaction, and these factors can make education through the application more popular among different educational fields.
基于手机的教育应用程序是虚拟教育中最有价值的工具之一。本研究旨在通过手机应用程序设计和评估2022年公共卫生专业学生实习的疫苗接种培训计划。方法采用人口普查抽样法,对30名女公共卫生专业大学生进行发展应用研究。首先确定了该计划的信息需求和技术能力。进行技能测试站测试,并记录分数。设计好的应用程序交给了学生,他们有一个月的时间来使用它。之后,再次进行相同的平稳测试,并将得分与第一次测试的得分进行比较。然后,使用第五版用户交互满意度(QUIS)问卷收集和分析用户对疫苗接种培训计划的满意度水平。收集的数据采用SPSS软件25版进行分析,采用Wilcoxon检验,显著性水平为0.05。结果采用EDU_VACCINE应用后,学生接种技能平均成绩由17.56±6.24分提高到60.4±2.15分(p < 0.05)。应用程序的平均总满意度得分为117.86±10.76 (p < 0.05)。结论根据调查结果,学生的疫苗接种绩效平均得分和教育-疫苗应用满意度均处于较高水平。“易于使用”和“离线”分别获得了最高的满意度,这些因素可以使通过应用程序进行教育在不同的教育领域更受欢迎。
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引用次数: 0
Future-ready military healthcare: Forensic odontology training and digital dental records integration in the Indian Armed Forces 面向未来的军事医疗保健:印度武装部队的法医牙科学培训和数字牙科记录整合
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2024.06.006
Poonam Prakash
Forensic odontology (FO) emerges as a critical discipline in conflict victim identification, particularly amid the challenges posed by war and calamities within the operational landscape of the Indian Armed Forces. FO plays an important role in improving the precision and efficacy of victim identification procedures in times of conflict.
In the aftermath of wars and calamities, traditional identification methods may be rendered inadequate due to factors such as mass casualties, decomposition, or disfigurement. One particularly important area of forensic science is odontology, which uses radiography, dental records and distinguishing dental characteristics to establish the identity of victims. Application of advanced technologies, including digital imaging and dental databases, further amplifies the precision and speed of identification efforts.
The abstract aims to highlight the significance of fostering specialized training programs for forensic odontologists within the Indian Armed Forces, ensuring their preparedness to confront the unique challenges of conflict victim identification. It emphasizes the interdisciplinary collaboration between forensic odontologists, pathologists and other forensic experts as essential for developing comprehensive and efficient identification protocols.
Integration of FO into the operational protocols of the Indian Armed Forces, will contribute to the establishment of a robust framework for conflict victim identification during war and calamities. This proactive approach will not only aid in bringing closure to grieving families but also plays a crucial role in upholding human rights and international humanitarian standards amid the complexities of conflict scenarios.
法医牙医学(FO)在冲突受害者鉴定中成为一门关键学科,特别是在印度武装部队作战环境中战争和灾难带来的挑战中。在冲突时期,FO在提高受害者识别程序的准确性和效率方面发挥着重要作用。在战争和灾难之后,由于大量伤亡、腐烂或毁容等因素,传统的识别方法可能会变得不充分。法医科学的一个特别重要的领域是牙科学,它使用放射照相、牙科记录和区分牙齿特征来确定受害者的身份。先进技术的应用,包括数字成像和牙科数据库,进一步提高了识别工作的精度和速度。摘要旨在强调在印度武装部队中培养法医牙科学专家专业培训计划的重要性,确保他们准备好面对冲突受害者身份识别的独特挑战。它强调法医牙科医生、病理学家和其他法医专家之间的跨学科合作,这对于制定全面有效的鉴定协议至关重要。将FO纳入印度武装部队的行动议定书将有助于建立一个在战争和灾难期间识别冲突受害者的强有力框架。这种积极主动的做法不仅有助于使悲痛的家庭得到了结,而且在复杂的冲突局势中,在维护人权和国际人道主义标准方面也发挥着至关重要的作用。
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引用次数: 0
Will Artificial Intelligence replace physicians? 人工智能会取代医生吗?
Q2 Medicine Pub Date : 2025-11-01 DOI: 10.1016/j.mjafi.2025.04.018
Avinash Supe
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引用次数: 0
Surgical airway management in Pierre Robin sequence: A case series 皮埃尔罗宾序列的外科气道管理:一个病例系列
Q2 Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.mjafi.2023.06.010
Divyanshi Sharma , Sandeep Dhingra , Shifa Bidhan , Subhash Chandra Shaw
Pierre Robin sequence (PRS) comprises three main components, i.e., micrognathia, glossoptosis, and upper airway obstruction. Infants who are born with PRS suffer from two major issues hampering survival and growth potential: (i) Upper airway obstruction and (ii) Feeding issues. PRS has variable presentations and surgical management in the more severe cases, when medical or conservative management fail, may help the child in minimising upper airway obstruction.
We report a case series of surgical airway management in PRS, describe the problems of airway obstruction that were faced, and the various outcomes by different management techniques.
Pierre Robin序列(PRS)包括三个主要组成部分,即小颌畸形、舌下垂和上气道阻塞。出生时患有PRS的婴儿有两个主要问题阻碍其生存和生长潜力:(i)上呼吸道阻塞和(ii)喂养问题。PRS有不同的表现,在更严重的情况下,当药物或保守治疗失败时,手术治疗可能有助于减少儿童的上气道阻塞。我们报告了PRS的外科气道管理病例系列,描述了所面临的气道阻塞问题,以及不同管理技术的不同结果。
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引用次数: 0
期刊
Medical Journal Armed Forces India
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