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Multiple myeloma with an unusual presentation 多发性骨髓瘤,表现不寻常
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2025.02.005
Sajitha K , Michelle Mathias
Central nervous system (CNS) involvement in multiple myeloma (MM) is rare and can be a challenge to diagnose due to the heterogenous symptoms and associated confounding neurological symptoms because of any other underlying condition. CNS - MM can occur either at the onset of the disease or during relapse when the myeloma is usually more aggressive and the patient would have already taken different types of treatments. CNS - MM has a grim prognosis inspite of the availability of newer modalities of pharmacologic treatment including immunomodulatory drugs and proteasome inhibitors. Here, we report a case of MM with CNS involvement at presentation which posed a diagnostic challenge. This case is being reported due to its rarity of occurrence and limited data available in literature.
多发性骨髓瘤(MM)的中枢神经系统(CNS)受累是罕见的,并且由于任何其他潜在疾病的异质性症状和相关的混淆神经症状,可能是诊断的挑战。中枢神经系统-多发性骨髓瘤可发生在发病时或复发时,此时骨髓瘤通常更具侵袭性,患者可能已经接受了不同类型的治疗。尽管有新的药物治疗方法,包括免疫调节药物和蛋白酶体抑制剂,但CNS - MM的预后很差。在这里,我们报告一例MM与中枢神经系统累及的表现提出了诊断挑战。本病例罕见,文献资料有限,故予以报道。
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引用次数: 0
The role of androgen receptors in breast cancer 雄激素受体在乳腺癌中的作用
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.03.008
Kalpana Ketan Kulkarni , Asha Kashinath Kubde

Background

Breast cancer is a heterogenous group of diseases with steroid hormone dependant carcinogenesis. Along with Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal growth factor Receptor 2 (HER2), androgen receptor (AR) is now emerging to play key role in disease progression of various molecular breast cancer subtypes especially triple negative breast cancers. Aim of this study was to find out prevalence of AR positivity in all breast cancers, correlation of ER, PR, HER2 and Ki67 index with AR positivity. To find out correlation of AR positivity with histological grade.

Methods

This was a descriptive cross-sectional study done on 55 primary breast carcinoma cases. Routine Hematoxylin and Eosin stain as well as immunohistochemical ER, PR, HER2/neu, Ki67 and AR stain were done. The outcome was assessed in the form of relationship between AR and ER, PR, HER2 status and Ki-67 index and histopathological grade.

Results

AR positivity was seen in 69% of all breast cancers. AR positivity was seen in 8% of triple negative breast cancers. High Ki67 index showed 55% AR positivity. Grade II breast cancers showed 42% AR positivity.

Conclusion

Cases with triple negative breast cancers have worst prognosis. Unlike targeted novel hormone therapy (tamoxifen) in luminal cancers and monoclonal antibody (trastuzumab) in her2 enriched cancers, AR is looked upon as a target to treat triple negative breast cancer. However, the existing controversies demand more AR related studies.
背景:乳腺癌是一种异质组的疾病与类固醇激素依赖的癌变。雄激素受体(AR)与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2 (HER2)一起,在各种分子乳腺癌亚型尤其是三阴性乳腺癌的疾病进展中发挥着关键作用。本研究的目的是了解所有乳腺癌中AR阳性的患病率,以及ER、PR、HER2和Ki67指数与AR阳性的相关性。探讨AR阳性与组织学分级的相关性。方法对55例原发性乳腺癌患者进行描述性横断面研究。常规苏木精染色、伊红染色及免疫组化ER、PR、HER2/neu、Ki67、AR染色。以AR与ER、PR、HER2状态、Ki-67指数及组织病理学分级的关系评估结果。结果69%的乳腺癌患者呈ar阳性。三阴性乳腺癌患者中有8%呈AR阳性。Ki67指数高,AR阳性55%。II级乳腺癌的AR阳性率为42%。结论三阴性乳腺癌患者预后最差。与靶向新型激素治疗(他莫昔芬)治疗腔内癌症和单克隆抗体(曲妥珠单抗)治疗her2富集癌症不同,AR被视为治疗三阴性乳腺癌的靶点。然而,存在的争议需要更多的AR相关研究。
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引用次数: 0
Detailing’ an obstetric conundrum with COVID-19 用 COVID-19 详细描述 "产科难题
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.04.001
Rohan Magoon, Jes Jose
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引用次数: 0
Four-hour voiding observation: Normative data from term Indian neonates 四小时排尿观察:来自足月印度新生儿的规范性数据
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2023.07.004
R.W. Thergaonkar , Vivek Bhat , Manisha Thakur , Ahmad Jamal , Shikha Awasthi

Background

The four-hour voiding observation is an important non-invasive urodynamic test for infants and young children before toilet training. The study was performed to generate normative data for term Indian neonates.

Methods

The study was a descriptive study performed in the Department of Paediatrics of a secondary care hospital in South India with patients having nationwide representation from August 2018 to August 2020. Term neonates, appropriate for gestational age on days 4–14 of life were included. Neonates at risk of oliguria or abnormal bladder functions were excluded. Four-hour voiding observation was performed by direct observation of voids, pre- and post-void diaper weight and measurement of post-void residue (PVR) by ultrasonography using two formulae within five minutes of voiding.

Results

A total of 102 neonates (166 voids) were studied. Important results were (a) Eight neonates did not void; (b) median (fifth–95th percentile) of important test outcomes as follows: voided volume: 15 (7.5–33.5) ml, maximum voided volume (MVV) 16.5 (8.0–38.7) ml, PVR 3.2 (0.5–10.2) ml, PVR% 17.0 (2.9–46.4) % functional bladder capacity 19.7 (9.6–38.0) ml, and diuresis: 1.7 (0.0–5.1) ml/kg/hour; (c) four (4.3%) neonates had one interrupted void each; (d) linear regression yielded the following formulae: MVV (ml) = 8.1019 + 4.8702 ∗Diuresis (ml/kg/hr) and PVR % (max) = 14.2312 + 3.2682∗ Diuresis (ml/kg/hr).

Conclusion

Normative data on the four-hour voiding observation study for Indian term exclusively breast-fed neonates are reported.
背景4小时排尿观察是婴幼儿如厕训练前一项重要的无创尿动力学检查。该研究是为了生成足月印度新生儿的规范数据。方法:本研究是一项描述性研究,于2018年8月至2020年8月在印度南部一家二级护理医院的儿科进行,患者具有全国代表性。包括4-14天与胎龄相符的足月新生儿。排除有少尿或膀胱功能异常风险的新生儿。在排尿5分钟内,采用2个公式,通过直接观察空隙、排尿前后纸尿裤重量和超声测量排尿后残留物(PVR)进行4小时的排尿观察。结果共调查新生儿102例(166例)。重要的结果是(a) 8个新生儿没有无效;(b)重要试验结果中位数(第5 - 95百分位)如下:排尿量:15 (7.5-33.5)ml,最大排尿量(MVV) 16.5 (8.0-38.7) ml, PVR 3.2 (0.5-10.2) ml, PVR% 17.0(2.9-46.4) %膀胱功能容量19.7 (9.6-38.0)ml,利尿量:1.7 (0.0-5.1)ml/kg/h;(c)四名(4.3%)新生儿每人有一次中断性空虚;(d)线性回归得到:MVV (ml) = 8.1019 + 4.8702 *利尿(ml/kg/hr), PVR % (max) = 14.2312 + 3.2682 *利尿(ml/kg/hr)。结论本文报道了印度足月纯母乳喂养新生儿4小时排空观察研究的规范性数据。
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引用次数: 0
Screening for Von Hipple-Lindau gene mutation and management of cerebellar hemangioblastoma presenting as erythrocytosis 小脑血管母细胞瘤表现为红细胞增多症的 Von Hipple-Lindau 基因突变筛查和处理方法
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.06.001
Abdeali Ginwala, Ajit Tambolkar
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引用次数: 0
Rapidly progressing respiratory failure in a young male: Diagnostic dilemma and treatment nightmare 年轻男性快速进展的呼吸衰竭:诊断困境和治疗噩梦
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.10.012
Manu Chopra, Monika Aggarwal, Utkarsh Suyal, P.K. Sharma, Rahul Tyagi, Alok D. Sen, Sanskar Kishore
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引用次数: 0
Demography of brain stem death and factors leading to successful consent for organ donation 脑干死亡的人口学及成功同意器官捐献的因素
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.05.007
Aditya A. Jha , Amit Singh , Sandhya Nair , Manish Manrai , Atul A. Jha , Sandeep Thareja , Pankaj P. Rao , Atul K. Sood , Praveen K. Sharma , Rajat Shukla

Background

There is a widening gap between the patients requiring transplants in proportion to the availability of organs donated. After brain stem death (BSD), counselling for consent is mandatory and if successful, and viable organs are recovered. A low consent rate for donation results in failed donation in a number of potential donors. Many potential donors fail to make a donation due to various social and familial reasons resulting in a poor consent rate. The aim of this study was to identify the variables that lead to donation denials.

Methods

This retrospective study, carried out from Jan 2009 to Dec 2021 at a tertiary centre with an active transplant and donation programme, analysed BSDs and their counselling outcomes.

Results

A total of 10998 patients were admitted to the intensive care unit, with 2401 (21.8%) deaths. BSD was diagnosed in 8.5% of all deaths, with donor suitability seen in 77.1% (n = 158) cases. After counselling, 55.7% families consented for organ donation. Amongst the families declining consent, most had multiple reasons. The commonest reasons were a difference of opinion among the family members (70%) and unclarity of BSD concept (44.3%). Other reasons included fear of mutilation, religious beliefs, and hope of a miracle.

Conclusion

As most reasons of denial are social and related to public awareness, a meticulous transplant program with enthusiastic coordinators coupled with augmentation of public awareness, responsible media reporting, and improved doctor–patient–relative communication would result in enhanced rates of consent.
需要移植器官的患者数量与捐献器官数量之间的差距越来越大。在脑干死亡(BSD)后,征求同意的咨询是强制性的,如果成功,可以恢复可存活的器官。捐赠同意率低导致许多潜在捐赠者捐赠失败。由于各种社会和家庭原因,许多潜在的捐赠者未能进行捐赠,导致同意率很低。这项研究的目的是确定导致拒绝捐赠的变量。方法本回顾性研究于2009年1月至2021年12月在一家具有活跃移植和捐赠计划的三级中心进行,分析了bsd及其咨询结果。结果重症监护病房共收治10998例患者,死亡2401例(21.8%)。在所有死亡病例中,诊断为BSD的占8.5%,供体适宜性占77.1% (n = 158)。经辅导后,55.7%的家庭同意捐赠器官。在拒绝同意的家庭中,大多数有多种原因。最常见的原因是家庭成员意见分歧(70%)和BSD概念不清楚(44.3%)。其他原因还包括对残害的恐惧、宗教信仰和对奇迹的希望。结论由于大多数拒绝的原因是社会性的,与公众意识有关,一个细致的移植计划,加上热情的协调员,公众意识的增强,负责任的媒体报道,以及改善医患之间的沟通,将提高同意率。
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引用次数: 0
Centchroman and tamoxifen in mastalgia: A randomized controlled trial Centchroman和他莫昔芬治疗乳房痛:一项随机对照试验
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.08.009
Mithilesh Kumar Sinha , Biswa Mohan Padhy , Ankur Gogoi Cheleng , Al Ameen Asharaf

Background

Mastalgia can be incapacitating for some individuals, necessitating medical intervention. Only a limited number of drugs have demonstrated effectiveness in managing the symptoms. An emerging option is oral centchroman, purported to be effective in this condition. Clinical trials are necessary to determine its role in the treatment of mastalgia.

Methods

An evaluator-blinded randomized controlled trial was conducted at a tertiary care teaching hospital to compare the efficacy of tamoxifen 10 mg and centchroman 30 mg daily. The study aimed to investigate the effect of treatment on the Visual Analog Scale (VAS) score of pain and the number of painful days per menstrual cycle or month. Following appropriate exclusion and randomization procedures, 51 patients completed the treatment and follow-up.

Results

Centchroman was more effective in controlling pain in the first month (p =0.04). No significant difference in the VAS score of pain was observed at the third or sixth month. Both drugs were effective in reducing the number of painful days, with no statistically significant difference between them. The recurrence rate at the sixth month was also not different (P = 0.41). Overall, 32% of patients on centchroman and 38.4% of patients on tamoxifen either failed to achieve satisfactory pain relief or experienced recurrences.

Conclusion

Centchroman is a safe and effective substitute for tamoxifen, demonstrating superior early symptom control, albeit with a slightly increased occurrence of adverse effects. In the event that no symptomatic relief is observed within a one-month trial of either medication, discontinuation is recommended, as prolonged use is unlikely to yield additional relief.
CTRI registration no.- CTRI/2021/01/030206.
背景:乳房痛可以使一些人丧失行为能力,需要医疗干预。只有有限数量的药物已证明对控制症状有效。一个新兴的选择是口服centchroman,据称对这种情况有效。临床试验是必要的,以确定其在治疗乳房痛的作用。方法在某三级教学医院进行一项评价者盲法随机对照试验,比较他莫昔芬10 mg / d与centchroman 30 mg / d的疗效。本研究旨在探讨治疗对疼痛的视觉模拟评分(VAS)评分和每个月经周期或每月疼痛天数的影响。经过适当的排除和随机化程序,51例患者完成了治疗和随访。结果scentchroman在第1个月的镇痛效果优于对照组(p =0.04)。第3个月和第6个月疼痛VAS评分差异无统计学意义。两种药物在减少疼痛天数方面都有效,两者之间没有统计学上的显著差异。6个月复发率差异无统计学意义(P = 0.41)。总的来说,32%的centchroman组患者和38.4%的他莫昔芬组患者未能达到令人满意的疼痛缓解或出现复发。结论centchroman是一种安全有效的他莫昔芬替代品,早期症状控制较好,但不良反应发生率略有增加。如果在任何一种药物的一个月的试验中没有观察到症状缓解,建议停药,因为长期使用不太可能产生额外的缓解。CTRI注册号:- CTRI / 2021/01/030206。
{"title":"Centchroman and tamoxifen in mastalgia: A randomized controlled trial","authors":"Mithilesh Kumar Sinha ,&nbsp;Biswa Mohan Padhy ,&nbsp;Ankur Gogoi Cheleng ,&nbsp;Al Ameen Asharaf","doi":"10.1016/j.mjafi.2024.08.009","DOIUrl":"10.1016/j.mjafi.2024.08.009","url":null,"abstract":"<div><h3>Background</h3><div>Mastalgia can be incapacitating for some individuals, necessitating medical intervention. Only a limited number of drugs have demonstrated effectiveness in managing the symptoms. An emerging option is oral centchroman, purported to be effective in this condition. Clinical trials are necessary to determine its role in the treatment of mastalgia.</div></div><div><h3>Methods</h3><div>An evaluator-blinded randomized controlled trial was conducted at a tertiary care teaching hospital to compare the efficacy of tamoxifen 10 mg and centchroman 30 mg daily. The study aimed to investigate the effect of treatment on the Visual Analog Scale (VAS) score of pain and the number of painful days per menstrual cycle or month. Following appropriate exclusion and randomization procedures, 51 patients completed the treatment and follow-up.</div></div><div><h3>Results</h3><div>Centchroman was more effective in controlling pain in the first month (<em>p =0.04</em>). No significant difference in the VAS score of pain was observed at the third or sixth month. Both drugs were effective in reducing the number of painful days, with no statistically significant difference between them. The recurrence rate at the sixth month was also not different (<em>P = 0.41</em>). Overall, 32% of patients on centchroman and 38.4% of patients on tamoxifen either failed to achieve satisfactory pain relief or experienced recurrences.</div></div><div><h3>Conclusion</h3><div>Centchroman is a safe and effective substitute for tamoxifen, demonstrating superior early symptom control, albeit with a slightly increased occurrence of adverse effects. In the event that no symptomatic relief is observed within a one-month trial of either medication, discontinuation is recommended, as prolonged use is unlikely to yield additional relief.</div><div><strong><em>CTRI registration no.-</em></strong> CTRI/2021/01/030206.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"81 ","pages":"Pages S109-S114"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Favipiravir-induced fluorescent nails and hair: A rare phenomenon favipirvir诱导的荧光指甲和头发:罕见现象
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.08.013
Anand Mannu, Rohit Kothari, Durga Madhab Tripathy, Pankaj Das
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引用次数: 0
Functional outcome after arthroscopic mosaicplasty for localised osteochondral defects in the knee 膝关节局部骨软骨缺损关节镜镶嵌成形术后的功能结果
Q2 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.mjafi.2024.09.001
Amresh Ghai , M.A. Jafri , S. Vignesh
Background: Knee injuries are commonly encountered in active sports persons as well as nonathletes, with approximately 60% of patients having cartilage damage with or without associated ligament and meniscal injuries. In this study, we report on the functional outcome of autologous osteochondral grafting in localised cartilage lesions of the knee.

Methods

A longitudinal follow-up study was conducted on 50 patients aged between 18-55 years with symptomatic focal cartilage defect in the knee of size less than 2.0 cm2 after necessary inclusion/exclusion criteria. Management involved arthroscopic autologous osteochondral grafting. The donor cartilage was from the non–weight-bearing region of the ipsilateral knee. Other associated intra-articular injuries were addressed in the same sitting. The patients were followed up after 6 weeks, 3 months and 6 months and clinical status documented by the Lysholm Knee Function Scale (LKFS).

Results

Most patients were young active males. Clinical presentation involved pain in all participants, followed by joint line tenderness. There was at least one associated injury to other intra-articular structures in 52% of the patients. The commonest associated injury was anterior cruciate ligament (ACL) tear followed by meniscus tear. The mean size of the focal cartilage defect was 1.013 cm2, ranging from 0.8 cm2 to 1.6 cm2. The mean preoperative LKFS was 56.97 ± 1.38 (standard error). There was a statistically (p < 0.001) as well as clinically significant (clinically important difference >13.0 and patient acceptable symptomatic state >70.0) improvement in the mean Lysholm score, which was 70 ± 1.32, 81.3 ± 1.12 and 92.1 ± 1.11 at the end of 6 weeks, 3 months and 6 months respectively. Eighty-four percent of the patients showed excellent functional outcome at 6 months (LKFS >90), whereas 8% and 4% had good and fair outcomes, respectively, at 6 months (LKFS: 70–90). Two patients (4%) who had failed ACL reconstruction had poor outcome (LKFS <70)at 6 months.

Conclusion

Mosaicplasty is an excellent procedure for managing cartilage defects of small to medium sizes, less than 2.0 cm2. The short-term results are satisfying and can accelerate rehabilitation of sports injuries. It is noteworthy that instability is a contra-indication for the procedure to succeed.
背景:膝关节损伤在活跃的运动员和非运动员中都很常见,大约60%的患者有软骨损伤,伴有或不伴有韧带和半月板损伤。在这项研究中,我们报告了自体骨软骨移植治疗膝关节局部软骨病变的功能结果。方法对50例年龄在18-55岁之间且膝关节局灶性软骨缺损小于2.0 cm2的患者进行纵向随访研究。治疗包括关节镜下自体骨软骨移植。供体软骨来自同侧膝关节的非负重区。其他相关的关节内损伤在同一坐姿中处理。随访时间分别为6周、3个月和6个月,采用Lysholm膝关节功能量表(LKFS)记录患者的临床状况。结果患者以年轻活跃男性居多。临床表现包括所有参与者的疼痛,其次是关节线压痛。在52%的患者中至少有一种其他关节内结构的相关损伤。最常见的相关损伤是前交叉韧带(ACL)撕裂,其次是半月板撕裂。局灶性软骨缺损的平均大小为1.013 cm2,范围为0.8 ~ 1.6 cm2。术前平均LKFS为56.97±1.38(标准误差)。统计学上(p <;6周、3个月和6个月时,Lysholm平均评分分别为70±1.32、81.3±1.12和92.1±1.11,显著改善(临床重要差异>;13.0,患者可接受症状状态>;70.0)。84%的患者在6个月时表现出良好的功能结果(LKFS >90),而8%和4%的患者在6个月时分别表现出良好和一般的结果(LKFS: 70-90)。2例ACL重建失败的患者(4%)在6个月时预后较差(LKFS <70)。结论镶嵌成形术是治疗小于2.0 cm2的中小型软骨缺损的一种很好的方法。短期效果满意,可促进运动损伤的康复。值得注意的是,不稳定性是手术成功的禁忌症。
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引用次数: 0
期刊
Medical Journal Armed Forces India
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