Pub Date : 2022-11-01DOI: 10.14710/dmj.v11i6.35882
Yuri Savitri, Wina Yunida M Siregar, Viola Septina, M. F. Arif, Arini Nashirah, Narisha Amelia Putri
Abstract Right Heart Failure (RHF) as a rapidly progressive syndrome with systemic congestion in the setting of impaired RV filling and/or decreased RV outflow output. A 28-year-old male patient, a photographer, lived in North Aceh was admitted to the ED of Cut Meutia Hospital. He was admitted with worsening dyspnea since 2 days before, initiated after a periode of fever. He also complained of fatigue, palpitations in ordinary activities and chest pain occasionally. He had history of presyncope and syncope. He denied any history of hypertension, type 2 diabetes, allergies, and active smoking. He had no congenital or family history of heart disease. Physical examination revealed full of conciousness with slightly abnormal vital sign. He had malar rash, dilated jugular vein. The apex of the heart shifts to the axilla anterior line, S1>S2 with systolic murmur (+). ECG showed complete RBBB with RAD and chest x-ray showed cardiomegaly. The transthoracic echocardiogram revealed severe TR (Tricuspid Regurgitation), dilatation of RARV (Right Atrium Right Ventricle), with severe PH (Pulmonary Hypertension). The patient was diagnosed with RHF (Right Heart Failure) caused by primary PH. The patient was placed on intravenous furosemide, spironolacton, digoxin, and sildenafil. Treatment and lifestyle modification were expected to improve the quality of life.
{"title":"A 28-Year-Old Male Patient With Right Heart Failure Due To Pulmonary Hypertension","authors":"Yuri Savitri, Wina Yunida M Siregar, Viola Septina, M. F. Arif, Arini Nashirah, Narisha Amelia Putri","doi":"10.14710/dmj.v11i6.35882","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35882","url":null,"abstract":"Abstract Right Heart Failure (RHF) as a rapidly progressive syndrome with systemic congestion in the setting of impaired RV filling and/or decreased RV outflow output. A 28-year-old male patient, a photographer, lived in North Aceh was admitted to the ED of Cut Meutia Hospital. He was admitted with worsening dyspnea since 2 days before, initiated after a periode of fever. He also complained of fatigue, palpitations in ordinary activities and chest pain occasionally. He had history of presyncope and syncope. He denied any history of hypertension, type 2 diabetes, allergies, and active smoking. He had no congenital or family history of heart disease. Physical examination revealed full of conciousness with slightly abnormal vital sign. He had malar rash, dilated jugular vein. The apex of the heart shifts to the axilla anterior line, S1>S2 with systolic murmur (+). ECG showed complete RBBB with RAD and chest x-ray showed cardiomegaly. The transthoracic echocardiogram revealed severe TR (Tricuspid Regurgitation), dilatation of RARV (Right Atrium Right Ventricle), with severe PH (Pulmonary Hypertension). The patient was diagnosed with RHF (Right Heart Failure) caused by primary PH. The patient was placed on intravenous furosemide, spironolacton, digoxin, and sildenafil. Treatment and lifestyle modification were expected to improve the quality of life.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124832954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.14710/dmj.v11i6.35942
R. Ananda, Asep Bayu Dani Nandiyanto
Background: A Study to determine the development of research can be done by bibliometric analysis technique. There are many studies that have been carried out on bibliometric analysis. However, research on bibliometric analysis of published data in the field of protein nanoparticles that has been carried out specifically to determine research development has not been carried out. Objective: This study aims to examine the development of protein nanoparticle research through a bibliometric approach. Methods: The article data was obtained from the Google Scholar database using the publish or perish reference manager software. The keyword "Protein Nanoparticles" is used with a publication time span from 2012 to 2022. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. Results: The article data obtained and considered relevant were 390 articles. The results of the analysis of the development of protein nanoparticle publications in the last 10 years show quite frequent fluctuations. Research fluctuations occurred in 2012 to 2020. There was a decline in 2020-2022 from 35 in 2020 to 19 in 2022. In 2012 and 2014 research on protein nanoparticles became popular, with 47 studies each. Conclusion: Based on the results of mapping the collected article data, it can be seen that the keyword protein nanoparticles is still rarely used in research. It can be concluded that the field of protein nanoparticles is still very likely to be researched and associated with other terms, this will have a higher impact on the novelty of the research.
{"title":"Bibliometric Analysis of Publication on Protein Nanoparticle Using VOSviewer","authors":"R. Ananda, Asep Bayu Dani Nandiyanto","doi":"10.14710/dmj.v11i6.35942","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35942","url":null,"abstract":"Background: A Study to determine the development of research can be done by bibliometric analysis technique. There are many studies that have been carried out on bibliometric analysis. However, research on bibliometric analysis of published data in the field of protein nanoparticles that has been carried out specifically to determine research development has not been carried out. \u0000Objective: This study aims to examine the development of protein nanoparticle research through a bibliometric approach. \u0000Methods: The article data was obtained from the Google Scholar database using the publish or perish reference manager software. The keyword \"Protein Nanoparticles\" is used with a publication time span from 2012 to 2022. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. \u0000Results: The article data obtained and considered relevant were 390 articles. The results of the analysis of the development of protein nanoparticle publications in the last 10 years show quite frequent fluctuations. Research fluctuations occurred in 2012 to 2020. There was a decline in 2020-2022 from 35 in 2020 to 19 in 2022. In 2012 and 2014 research on protein nanoparticles became popular, with 47 studies each. \u0000Conclusion: Based on the results of mapping the collected article data, it can be seen that the keyword protein nanoparticles is still rarely used in research. It can be concluded that the field of protein nanoparticles is still very likely to be researched and associated with other terms, this will have a higher impact on the novelty of the research.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132259473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.14710/dmj.v11i6.35993
Yuri Savitri, Helma Humairah, Jauza Raudhatul Jannah Mendrofa, N. Afni, Della Vega Nisha Ayuna
Rheumatic heart disease (RHD) is damage of the heart valves due to acute rheumatic fever (ARF) which results from the body’s autoimmune response to Streptococcus pyogenes (group A Streptococcus bacteria) infection which is a throat infection. Acute rheumatic fever is one of the most important causes of cardiovascular morbidity and mortality in the developing countries. A 25-years-old male patient, domiciled in Alue Dalam, Darul Aman, East Aceh, admitted to emergency department of Cut Mutia hospital, the patient was brought to the hospital by his family at 05.0o pm on January 27th, 2022. Patient referred from Graha Bunda hospital. Patient was admitted to the hospital with complaints shortness of breath. Shortness of breath is felt during activity and worsens at night. Shortness of breath since yesterday. The patient also complained of pounding. The pounding has been felt for five days before arriving at the hospital. The patient also has chest pain, and tired easily. Past medical history such hypertension and diabetes mellitus are denied. Physical examination before treatment was obtained: the patient looked restless, weakness, and akker. Echocardiography examination showed the MR Severe, MS moderate, AR moderate, TR moderate, PH mild, AML calsification, all chamber dilatation, and thrombus LV. The patient was given initial treatment in Cut Mutia General Hospital.
风湿性心脏病(RHD)是由急性风湿热(ARF)引起的心脏瓣膜损伤，这是由身体对化脓性链球菌(A组链球菌)感染(一种喉咙感染)的自身免疫反应引起的。急性风湿热是发展中国家心血管疾病发病和死亡的最重要原因之一。一名25岁男性患者，居住在东亚齐省Darul Aman的Alue Dalam，于2022年1月27日下午5点由其家人带到医院急诊科。格拉哈·本达医院转来的病人。病人因主诉呼吸短促而住进医院。活动时感到呼吸急促，夜间加重。从昨天开始呼吸急促。病人还抱怨有重击感。在到达医院之前，这种重击感已经持续了五天。病人还有胸痛，而且容易疲倦。否认既往病史，如高血压和糖尿病。治疗前进行体格检查:患者看起来坐立不安、虚弱、虚弱。超声心动图检查示MR Severe, MS moderate, AR moderate, TR moderate, PH mild, AML分级，全室扩张，血栓LV。患者在切穆提亚总医院接受初步治疗。
{"title":"Patient With RHD Ec MR Severe, MS Moderate And Trombus In LV, When We Do The Surgeom In Cut Meutia Regional General Hospital","authors":"Yuri Savitri, Helma Humairah, Jauza Raudhatul Jannah Mendrofa, N. Afni, Della Vega Nisha Ayuna","doi":"10.14710/dmj.v11i6.35993","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35993","url":null,"abstract":"Rheumatic heart disease (RHD) is damage of the heart valves due to acute rheumatic fever (ARF) which results from the body’s autoimmune response to Streptococcus pyogenes (group A Streptococcus bacteria) infection which is a throat infection. Acute rheumatic fever is one of the most important causes of cardiovascular morbidity and mortality in the developing countries. A 25-years-old male patient, domiciled in Alue Dalam, Darul Aman, East Aceh, admitted to emergency department of Cut Mutia hospital, the patient was brought to the hospital by his family at 05.0o pm on January 27th, 2022. Patient referred from Graha Bunda hospital. Patient was admitted to the hospital with complaints shortness of breath. Shortness of breath is felt during activity and worsens at night. Shortness of breath since yesterday. The patient also complained of pounding. The pounding has been felt for five days before arriving at the hospital. The patient also has chest pain, and tired easily. Past medical history such hypertension and diabetes mellitus are denied. Physical examination before treatment was obtained: the patient looked restless, weakness, and akker. Echocardiography examination showed the MR Severe, MS moderate, AR moderate, TR moderate, PH mild, AML calsification, all chamber dilatation, and thrombus LV. The patient was given initial treatment in Cut Mutia General Hospital.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125379359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.14710/dmj.v11i6.35990
Yuri Savitri, Jauza Raudhatul Jannah Mendrofa
Rheumatic heart disease (rheumatic heart disease) is an acquired heart disease which is a heart valve disorder that persists due to previous acute rheumatic fever, mainly affecting the mitral valve (75%), the aorta (25%), rarely affecting the tricuspid valve, and never affecting the valves lungs. A 52-year-old male patient, domiciled in Mutiara (Alue Awe) Lhokseumawe City, Indonesia. Come for outpatient treatment at Polyclinic of Cut Meutia Hospital. Patients are who routinely go to the polyclinic every month to take medicine. The patient complains of left chest pain, shortness of breath, heart palpitations, cough, tired easily during activities, especially during strenuous activities. History of Diabetes Mellitus is denied, history of hypertension (+). The patient admitted that he was diagnosed with rheumatic heart disease at the age of 19 years. The patient has been undergoing treatment for 33 years by routinely complete checks related to his heart every year and regularly taking medication at the polyclinic every month. The patient admitted at junior high school age he often experienced attacks of fever that went up and down accompanied by pain in the throat. Physical examination found: Compos Mentis (E4V5M6), BP:140/40 mmHg, HR : 92x/i, RR: 23x/i, T; 37.1°C, SpO2 : 95%. Chest examination showed vesicular breath sounds, Rhonki (-), Wheezing (-), Diastolic murmur (+).Echocardiography showed an EF of 70%. AR Severe, MR Moderate. AML Prolapse, Calcification (+), LV Dilatation, LVH Eccentric
{"title":"A 52-Years Old Male Patient With Aorta Regurgitation Et Causa Rheumatic Heart Desease In Cut Meutia Regional General Hospital","authors":"Yuri Savitri, Jauza Raudhatul Jannah Mendrofa","doi":"10.14710/dmj.v11i6.35990","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35990","url":null,"abstract":"Rheumatic heart disease (rheumatic heart disease) is an acquired heart disease which is a heart valve disorder that persists due to previous acute rheumatic fever, mainly affecting the mitral valve (75%), the aorta (25%), rarely affecting the tricuspid valve, and never affecting the valves lungs. A 52-year-old male patient, domiciled in Mutiara (Alue Awe) Lhokseumawe City, Indonesia. Come for outpatient treatment at Polyclinic of Cut Meutia Hospital. Patients are who routinely go to the polyclinic every month to take medicine. The patient complains of left chest pain, shortness of breath, heart palpitations, cough, tired easily during activities, especially during strenuous activities. History of Diabetes Mellitus is denied, history of hypertension (+). The patient admitted that he was diagnosed with rheumatic heart disease at the age of 19 years. The patient has been undergoing treatment for 33 years by routinely complete checks related to his heart every year and regularly taking medication at the polyclinic every month. The patient admitted at junior high school age he often experienced attacks of fever that went up and down accompanied by pain in the throat. Physical examination found: Compos Mentis (E4V5M6), BP:140/40 mmHg, HR : 92x/i, RR: 23x/i, T; 37.1°C, SpO2 : 95%. Chest examination showed vesicular breath sounds, Rhonki (-), Wheezing (-), Diastolic murmur (+).Echocardiography showed an EF of 70%. AR Severe, MR Moderate. AML Prolapse, Calcification (+), LV Dilatation, LVH Eccentric","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132599752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.14710/dmj.v11i6.35896
Deaniar Hafilah, A. Nandiyanto
Background: Nanocrystalline cellulose has potential for biomedical applications due to its abundant material availability, biodegradability, biocompatibility, and low weight. Research on nanocrystalline cellulose as medical implants has rarely been studied in the past 10 years, although this material has tremendous potential such as bone implants and cardiovascular implants. Objective: This study aims to analyze the development of research on nanocrystalline cellulose as medical implants using a bibliometric approach with computational analysis using VOSviewer. Methods: The article data was obtained using the Publish or Perish software by retrieving the database from Google Scholar. The keyword “nanocrystalline cellulose, medical implants, biomedical" is used with the publication time span from 2012 to 2020. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. Results: Research on the application of nanocrystalline cellulose has been carried out several times, this can be proven from computational mapping analysis using VOSviewer which shows the term "nanocrystalline cellulose" is in the same cluster as the term "medical implant". However, research on the application of nanocrystalline cellulose as medical implants is still rarely carried out, this is evidenced by the small frequency indicated by the two terms. Conclusion: Based on the results of mapping the collected article data, research on the application of nanocrystalline cellulose as medical implants is an interesting topic. However, this topic is still rarely studied. Therefore, this review can be a starting point for selecting the topic of research on the application of nanocrystalline cellulose materials as medical implants as a consideration for determining the research theme to be taken.
背景:纳米晶纤维素由于其丰富的材料可用性、生物可降解性、生物相容性和重量轻而具有潜在的生物医学应用。虽然纳米纤维素在骨植入、心血管植入等方面具有巨大的应用潜力，但其作为医用植入材料的研究在近10年来很少。目的:利用文献计量学方法，结合VOSviewer的计算分析，分析纳米纤维素作为医用植入物的研究进展。方法:通过检索Google Scholar数据库，使用Publish or Perish软件获取文章数据。关键词“纳米晶纤维素，医用植入物，生物医学”，发表时间跨度为2012 - 2020年。数据处理使用Microsoft Excel。使用VOSviewer计算映射。结果:关于纳米晶纤维素的应用研究已经进行了多次，这可以从VOSviewer的计算映射分析中得到证明，“纳米晶纤维素”一词与“医用植入物”一词处于同一簇。然而，纳米晶纤维素作为医疗植入物的应用研究仍然很少，这两个术语的出现频率很低。结论:基于收集到的文献数据的映射结果，纳米晶纤维素作为医疗植入物的应用研究是一个有趣的话题。然而，这一课题的研究仍然很少。因此，这篇综述可以作为选择纳米晶纤维素材料作为医疗植入物的研究课题的起点，作为确定研究主题的考虑因素。
{"title":"A Bibliometric Analysis of Nanocrystalline Cellulose Research as Medical Implant Using VOSviewer","authors":"Deaniar Hafilah, A. Nandiyanto","doi":"10.14710/dmj.v11i6.35896","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35896","url":null,"abstract":"Background: Nanocrystalline cellulose has potential for biomedical applications due to its abundant material availability, biodegradability, biocompatibility, and low weight. Research on nanocrystalline cellulose as medical implants has rarely been studied in the past 10 years, although this material has tremendous potential such as bone implants and cardiovascular implants. \u0000Objective: This study aims to analyze the development of research on nanocrystalline cellulose as medical implants using a bibliometric approach with computational analysis using VOSviewer. \u0000Methods: The article data was obtained using the Publish or Perish software by retrieving the database from Google Scholar. The keyword “nanocrystalline cellulose, medical implants, biomedical\" is used with the publication time span from 2012 to 2020. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. \u0000Results: Research on the application of nanocrystalline cellulose has been carried out several times, this can be proven from computational mapping analysis using VOSviewer which shows the term \"nanocrystalline cellulose\" is in the same cluster as the term \"medical implant\". However, research on the application of nanocrystalline cellulose as medical implants is still rarely carried out, this is evidenced by the small frequency indicated by the two terms. \u0000Conclusion: Based on the results of mapping the collected article data, research on the application of nanocrystalline cellulose as medical implants is an interesting topic. However, this topic is still rarely studied. Therefore, this review can be a starting point for selecting the topic of research on the application of nanocrystalline cellulose materials as medical implants as a consideration for determining the research theme to be taken.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"65 2 Spec No 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126770230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.14710/dmj.v11i5.35895
Meiriani Sari, N. Hairunisa
Monkeypox disease (monkey smallpox) is a disease that has never been found in Indonesia since it was first discovered in humans in the Congo in 1970. So if there is one positive confirmed event, then the disease is an Extraordinary Event (KLB). This disease has become a global concern because since May 13, 2022, WHO has received reports of Monkeypox cases from non-endemic countries. It has expanded to 4 WHO regions: Europe, America, Eastern Mediterranean, and Western Pacific. Until now, further investigations and studies are still being carried out to understand more about the epidemiology, sources of infection, and transmission patterns in non-endemic countries that have reported new cases, such as Indonesia. Until now, no specific treatment has been proven to treat Monkeypox infection. Currently, the therapy used is symptomatic support. The antiviral tecovirimat, or TPOXX, developed by the European Medicines Agency (EMA) as a Monkeypox therapy in 2022 based on research, has not been marketed freely. In addition, antivirals such as cidofovir and brincidofovir have been shown to be effective against orthopox virus in vitro and in animal studies. However, the effectiveness of this drug against monkeypox in humans is not yet known. However, this disease can be prevented by vaccination. In Indonesia, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is recommended to prevent Monkeypox disease. The existence of the outbreak report is important to discuss, explore, and understand more about the disease and its management and prevention.
{"title":"A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022","authors":"Meiriani Sari, N. Hairunisa","doi":"10.14710/dmj.v11i5.35895","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35895","url":null,"abstract":"Monkeypox disease (monkey smallpox) is a disease that has never been found in Indonesia since it was first discovered in humans in the Congo in 1970. So if there is one positive confirmed event, then the disease is an Extraordinary Event (KLB). This disease has become a global concern because since May 13, 2022, WHO has received reports of Monkeypox cases from non-endemic countries. It has expanded to 4 WHO regions: Europe, America, Eastern Mediterranean, and Western Pacific. Until now, further investigations and studies are still being carried out to understand more about the epidemiology, sources of infection, and transmission patterns in non-endemic countries that have reported new cases, such as Indonesia. Until now, no specific treatment has been proven to treat Monkeypox infection. Currently, the therapy used is symptomatic support. The antiviral tecovirimat, or TPOXX, developed by the European Medicines Agency (EMA) as a Monkeypox therapy in 2022 based on research, has not been marketed freely. In addition, antivirals such as cidofovir and brincidofovir have been shown to be effective against orthopox virus in vitro and in animal studies. However, the effectiveness of this drug against monkeypox in humans is not yet known. However, this disease can be prevented by vaccination. In Indonesia, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is recommended to prevent Monkeypox disease. The existence of the outbreak report is important to discuss, explore, and understand more about the disease and its management and prevention.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131051256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-29DOI: 10.14710/dmj.v11i5.35479
Nazilla Jufril, H. Hardian, Darmawati Ayu Indraswari, Endang Kumaidah
Background: Physical activity has protective effects against the development of depression symptoms for all age groups. Cognitive training and aerobic training are lifestyle interventions that have been shown to have a positive impact on health, reducing cognitive impairment, and delaying the onset of dementia. Jump rope training is one type of aerobic training. Aerobic training is effective in improving mood. Objective: This study aims to prove the effect of jump rope training on adolescent’s mood as measured by the POMS score. Methods: This is an experimental study with 2 parallel groups pre-test and post-test design. The research subjects were 32 students of senior-high school 1 of Gunung Talang, Solok Regency, West Sumatra that were selected by purposive sampling and grouped into 2 groups. The control group without treatment (n=16), and the treatment group (n=16) were given jump rope training for 6 weeks. Mood scores were measured before and after the intervention using a profile of mood state (POMS) questionnaire and expressed as total mood disturbance (TMD) scores. Results: The research shown the significant decreases of TMD scores (p<0.001) on the treatment group rather than the control group. In addition, there was a significant difference between the post-test TMD scores of the control group and the treatment group (p=0.005). Conclusion: Jump rope training for 6 weeks can improve the mood of the adolescent.Keywords: aerobic training, jump rope training, mood, profile of mood state, total mood disturbance
{"title":"The Effect of Jump Rope Training on Mood Among Senior High School Students","authors":"Nazilla Jufril, H. Hardian, Darmawati Ayu Indraswari, Endang Kumaidah","doi":"10.14710/dmj.v11i5.35479","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35479","url":null,"abstract":"Background: Physical activity has protective effects against the development of depression symptoms for all age groups. Cognitive training and aerobic training are lifestyle interventions that have been shown to have a positive impact on health, reducing cognitive impairment, and delaying the onset of dementia. Jump rope training is one type of aerobic training. Aerobic training is effective in improving mood. Objective: This study aims to prove the effect of jump rope training on adolescent’s mood as measured by the POMS score. Methods: This is an experimental study with 2 parallel groups pre-test and post-test design. The research subjects were 32 students of senior-high school 1 of Gunung Talang, Solok Regency, West Sumatra that were selected by purposive sampling and grouped into 2 groups. The control group without treatment (n=16), and the treatment group (n=16) were given jump rope training for 6 weeks. Mood scores were measured before and after the intervention using a profile of mood state (POMS) questionnaire and expressed as total mood disturbance (TMD) scores. Results: The research shown the significant decreases of TMD scores (p<0.001) on the treatment group rather than the control group. In addition, there was a significant difference between the post-test TMD scores of the control group and the treatment group (p=0.005). Conclusion: Jump rope training for 6 weeks can improve the mood of the adolescent.Keywords: aerobic training, jump rope training, mood, profile of mood state, total mood disturbance","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132100630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-14DOI: 10.14710/dmj.v11i5.35628
T. Handoyo, Nurain Farhanah, Gianina Dinda Pamungkas
Background : Treatment of COVID-19 using IL-6 inhibitors, including Sarilumab or Tocilizumab, significantly decreased mortality risk. Though, Remdesivir therapy gave benefits, morbidity and mortality remained high. Baricitinib, a JAK inhibitor, can inhibit IL-6 activation pathway and has a potential effect of inhibiting disease progression to become severe. Objective : This study aimed to evaluate the use of Baricitinib for COVID-19 patients. Methods : This study was conducted by searching for observational and randomized controlled trial studies through online databases, “PubMed” and “Google Scholar”. Studies included must evaluate Baricitinib effectivity as therapy for hospitalized COVID-19 patients. This study included 11 studies (9 observational and 2 randomized controlled trial). Patients included had moderate-to-severe symptoms of COVID-19. Results : Standard dose of Baricitinib was administered at 4 mg daily dose. Length of therapy was varied between 5-14 days, or up to patients’ discharge. Baricitinib therapy among included studies was administered with intravenous Remdesivir, Steroid, Tocilizumab, or other complement therapies. Mortality rate within 7-day of hospitalization with Baricitinib was 4.4%. Requirement of invasive mechanic ventilation rate after Baricitinib administration was approximately 4%. Laboratory parameters were significantly getting better after Baricitinib administration: IL-6; CRP; ferritin; and D-dimer. Serious adverse events in a randomized controlled trial, occurred more often in placebo treated compared to Baricitinib treated group. Conclusion : Baricitinib as therapy for COVID-19 patients can decrease progression, morbidity, and mortality of the disease. Further studies are needed to evaluate the benefit of Baricitinib as main therapy for COVID-19.
{"title":"Baricitinib as Treatment Option for Corona Virus Disease-19: a Literature Review","authors":"T. Handoyo, Nurain Farhanah, Gianina Dinda Pamungkas","doi":"10.14710/dmj.v11i5.35628","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35628","url":null,"abstract":"Background : Treatment of COVID-19 using IL-6 inhibitors, including Sarilumab or Tocilizumab, significantly decreased mortality risk. Though, Remdesivir therapy gave benefits, morbidity and mortality remained high. Baricitinib, a JAK inhibitor, can inhibit IL-6 activation pathway and has a potential effect of inhibiting disease progression to become severe. \u0000Objective : This study aimed to evaluate the use of Baricitinib for COVID-19 patients. \u0000Methods : This study was conducted by searching for observational and randomized controlled trial studies through online databases, “PubMed” and “Google Scholar”. Studies included must evaluate Baricitinib effectivity as therapy for hospitalized COVID-19 patients. This study included 11 studies (9 observational and 2 randomized controlled trial). Patients included had moderate-to-severe symptoms of COVID-19. \u0000Results : Standard dose of Baricitinib was administered at 4 mg daily dose. Length of therapy was varied between 5-14 days, or up to patients’ discharge. Baricitinib therapy among included studies was administered with intravenous Remdesivir, Steroid, Tocilizumab, or other complement therapies. Mortality rate within 7-day of hospitalization with Baricitinib was 4.4%. Requirement of invasive mechanic ventilation rate after Baricitinib administration was approximately 4%. Laboratory parameters were significantly getting better after Baricitinib administration: IL-6; CRP; ferritin; and D-dimer. Serious adverse events in a randomized controlled trial, occurred more often in placebo treated compared to Baricitinib treated group. \u0000Conclusion : Baricitinib as therapy for COVID-19 patients can decrease progression, morbidity, and mortality of the disease. Further studies are needed to evaluate the benefit of Baricitinib as main therapy for COVID-19.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129211522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-14DOI: 10.14710/dmj.v11i5.35640
Rosalia Indri Dewanti, V. R. Ciptaningtyas, Ryan Halleyantoro, Gustantyo Wahyu Wibobo
Background: Streptococcus mutans was the most dominant bacteria in caused caries. Caries could be prevented by chemical plaque control methods used toothpaste. Toothpaste had antibacterial properties by helped to prevent bacteria from colonized. There were two antibacterial ingredients in toothpaste, fluoride and herbal ingredients. Aim: Determined the antibacterial effect of toothpaste with herbal and fluoride content on the growth of Streptococcus mutans. Methods: This study was an experimental study with a post-test only control group design. This research method was a diffusion method by means of wells. The sample used was the Streptococcus mutans colony. The study was divided into four groups, namely herbal toothpaste, fluoride toothpaste, positive control (chlorhexidine), and negative control (aquadest sterile) which were replicated 16 times in each group. The results of this study was the diameter of the resistance zone. Results: The average diameter of the zone of inhibition results obtained 12.49 mm (herbal toothpaste), 14.66 mm (fluoride toothpaste), 21.70 mm (chlorhexidine) and aquadest sterile there were no inhibition zones. There was a significant difference with the p value
{"title":"COMPARISON OF ANTIBACTERIAL EFFECTIVENESS OF HERBAL TOOTHPASTE AND FLUORIDE ON THE GROWTH OF Streptococcus mutans","authors":"Rosalia Indri Dewanti, V. R. Ciptaningtyas, Ryan Halleyantoro, Gustantyo Wahyu Wibobo","doi":"10.14710/dmj.v11i5.35640","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35640","url":null,"abstract":"Background: Streptococcus mutans was the most dominant bacteria in caused caries. Caries could be prevented by chemical plaque control methods used toothpaste. Toothpaste had antibacterial properties by helped to prevent bacteria from colonized. There were two antibacterial ingredients in toothpaste, fluoride and herbal ingredients. \u0000Aim: Determined the antibacterial effect of toothpaste with herbal and fluoride content on the growth of Streptococcus mutans. \u0000Methods: This study was an experimental study with a post-test only control group design. This research method was a diffusion method by means of wells. The sample used was the Streptococcus mutans colony. The study was divided into four groups, namely herbal toothpaste, fluoride toothpaste, positive control (chlorhexidine), and negative control (aquadest sterile) which were replicated 16 times in each group. The results of this study was the diameter of the resistance zone. \u0000Results: The average diameter of the zone of inhibition results obtained 12.49 mm (herbal toothpaste), 14.66 mm (fluoride toothpaste), 21.70 mm (chlorhexidine) and aquadest sterile there were no inhibition zones. There was a significant difference with the p value","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123464137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-14DOI: 10.14710/dmj.v11i5.35304
M. Ilham, Endang Mahati, M. Muniroh, Y. Nindita
ABSTRACTBackground: Antioxidant is a substance that can catch and neutralize free radicals so that the process of oxidative stress can be stopped and cell damage can be avoided. Kaffir lime peel contains antioxidant compounds that have the potential to be the neuroprotective agent and can protect neurons from free radical-induced damage.Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the plasma malondialdehyde (MDA) level of mice induced by Scopolamine (SCM).Method: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups consisting of a healthy control (K+), Negative Control (K-), extract 5 mg/20gBW group (P1), 10 mg/20gBW group (P2), 20 mg/20gBW group (P3). SCM was injected intraperitoneally on days 1-7 and kaffir lime peel extract was given orally on days 2-7, the MDA levels testing of mice using TBARS method on day 8. Data analysis used One-Way ANOVA test and continued with Post Hoc LSD test.Results: The mean MDA levels of K+, K-, P1, P2, P3 were 4,212; 4,644; 3,481; 4,555; 4,733 nmol/mL, respectively. MDA levels of P1 were lower than K-, even though there were no statistically significant differences.Conclusion: There was no effect of administration kaffir lime peel extract (Citrus hystrix) on MDA levels in mice with scopolamine-induced dementia.Keywords: Citrus hystrix, malondialdehyde, dementia, mice
摘要背景:抗氧化剂是一种能够捕获和中和自由基，从而阻止氧化应激过程，避免细胞损伤的物质。Kaffir酸橙皮含有抗氧化化合物，有可能成为神经保护剂，可以保护神经元免受自由基引起的损伤。目的:探讨青柠皮提取物对东莨菪碱(SCM)致小鼠血浆丙二醛(MDA)水平的影响。方法:本研究为真正意义上的实验研究，采用后验对照组设计。30只小鼠随机分为5组，分别为健康对照组(K+)、阴性对照组(K-)、提取物5 mg/20gBW组(P1)、10 mg/20gBW组(P2)、20 mg/20gBW组(P3)。第1-7天腹腔注射SCM，第2-7天口服kaffir青柠皮提取物，第8天采用TBARS法检测小鼠丙二醛水平。数据分析采用单因素方差分析，并继续采用Post Hoc LSD检验。结果:大鼠血清K+、K-、P1、P2、P3平均MDA水平为4212;4644;3481;4555;分别为4733 nmol/mL。P1的MDA水平低于K-，但差异无统计学意义。结论:枸杞皮提取物对东莨菪碱致痴呆小鼠MDA水平无影响。关键词:柑桔，丙二醛，痴呆，小鼠
{"title":"THE EFFECTIVENESS OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON PLASMA MALONDIALDEHYDE LEVEL IN DEMENTIA MICE","authors":"M. Ilham, Endang Mahati, M. Muniroh, Y. Nindita","doi":"10.14710/dmj.v11i5.35304","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35304","url":null,"abstract":"ABSTRACTBackground: Antioxidant is a substance that can catch and neutralize free radicals so that the process of oxidative stress can be stopped and cell damage can be avoided. Kaffir lime peel contains antioxidant compounds that have the potential to be the neuroprotective agent and can protect neurons from free radical-induced damage.Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the plasma malondialdehyde (MDA) level of mice induced by Scopolamine (SCM).Method: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups consisting of a healthy control (K+), Negative Control (K-), extract 5 mg/20gBW group (P1), 10 mg/20gBW group (P2), 20 mg/20gBW group (P3). SCM was injected intraperitoneally on days 1-7 and kaffir lime peel extract was given orally on days 2-7, the MDA levels testing of mice using TBARS method on day 8. Data analysis used One-Way ANOVA test and continued with Post Hoc LSD test.Results: The mean MDA levels of K+, K-, P1, P2, P3 were 4,212; 4,644; 3,481; 4,555; 4,733 nmol/mL, respectively. MDA levels of P1 were lower than K-, even though there were no statistically significant differences.Conclusion: There was no effect of administration kaffir lime peel extract (Citrus hystrix) on MDA levels in mice with scopolamine-induced dementia.Keywords: Citrus hystrix, malondialdehyde, dementia, mice","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122824862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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