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THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY 丙戊酸与托吡酯长期联合治疗对癫痫患儿血清维生素d水平的影响
Pub Date : 2021-12-24 DOI: 10.14710/dmj.v11i1.32563
Hexanto Muhartomo, M. Widiastuti, Endang Kustiowati, A. Bintoro, Arinta Puspita Wati, A. Putranti, R. P. Sinaga
Background: Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.Objective: To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramateMethods: A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.Results: The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).Conclusion: There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy
背景:癫痫是一种以无端发作为特征的慢性疾病。维生素D在儿童发育过程中是必需的,并且受到抗癫痫药物的强烈影响。目的:探讨丙戊酸联合托吡酯治疗癫痫患儿治疗时间与血清维生素D水平的相关性。方法:对三宝朗Dr. Kariadi医院40例5-10岁儿童癫痫患者进行横断面研究。血清维生素D水平检测采用ELISA法。统计学分析采用Spearman相关检验和偏相关检验,显著性水平p = 0.05。结果:联合治疗24个月后患者血清维生素D水平平均值为21.87±1.21ng/ml,仍有癫痫发作者血清维生素D水平平均值为27.94±2.40ng/ml,延迟治疗者血清维生素D水平平均值为23.23±2.07ng/ml。双变量分析显示,治疗持续时间(rho= -0.850, p<0.001)、治疗开始时间(rho=0.604, p<0.001)和癫痫发作频率(rho=0.559, p<0.001)与血清维生素D水平呈负相关。偏相关分析显示,治疗持续时间与经治疗开始调整后的血清维生素D水平(rho=-0.839, p<0.001)和癫痫发作频率(rho=-0.856, p<0.001)具有显著相关性。结论:癫痫患儿治疗时间与血清维生素D水平存在相关性
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引用次数: 0
EFFECT OF DIFFERENT CONCENTRATION CINNAMON EXTRACTS (CINNAMOMUM BURMANNII) IN GROWTH LACTOBACILLUS ACIDOPHILUS (IN VITRO) 不同浓度肉桂提取物对嗜酸乳杆菌生长的影响(体外)
Pub Date : 2021-12-15 DOI: 10.14710/dmj.v11i1.30523
Sherlin Mentary Farizha, D. Armalina, D. A. Purbaningrum
Background: One of the dental and oral health problem that really need attention is caries. Lactobacillus acidophilus is one of the bacteria that play a role in the process of further caries in dentin. We can control it by using materials like antibacterial. Cinnamon barks (Cinnamomum burmannii) is a plant from Indonesia that contains antibacterial compounds such as sinamaldehid, flavonoid, tannins, alkaloids, and saponinsPurpose: To know the effect of various concentrations of cinnamon barks extracts (Cinamomum burmannii) on the growth of Lactobacillus acidophilus in vitroMethod: True experimental study with the post test control group design has 25 samples. Cinnamon barks was extracted by the soxhletation method then phytochemical tests were performed to determine the antibacterial compounds. Antibacterial tested using the diffusion method to determine the diameter of the inhibitory zone. Statistical tests using Kruskal-Wallis and Man-WhitneyResult: The mean inhibition zone diameters at concentrations of 6.25%, 12.5%, 25%, 50%, and positive controls were 4.80 mm, 10.99 mm, 16.83 mm, 19.14 mm, 29, 80 mm. Kruskal Wallis test showed significant differences in inhibition zone diameter in inhibiting the growth of Lactobacillus acidophilus p = 0,000321 (p <0.05). The Man Whitnney test showed a significant difference between the concentration of 6.25% with concentrations of 25% and 50% and concentrations of 12.5% with concentrations of 25% and 50%. There were no significant differences between the concentrations of 6.25% with 12.5% and 25 % with 50%Conclusion: There is an effect of cinnamon bark extracts from various concentrations on the growth of Lactobacillus acidophillus as assessed by the formation of inhibition zone diameters. The 25% concentration is the minimum concentration that can significantly inhibit bacteria
背景:龋齿是牙齿和口腔健康中真正需要关注的问题之一。嗜酸乳杆菌是在牙本质龋的进一步发展过程中起作用的细菌之一。我们可以通过使用抗菌剂等材料来控制它。肉桂皮(Cinnamomum burmannii)是一种来自印度尼西亚的植物,含有肉桂醛、类黄酮、单宁、生物碱、皂苷等抗菌化合物。目的:了解不同浓度肉桂皮提取物(Cinamomum burmannii)对嗜酸乳杆菌体外生长的影响。方法:采用试验后对照组设计,共25个样品进行真实实验研究。采用索氏法提取肉桂皮,进行植物化学试验,测定其抗菌成分。抑菌试验采用扩散法测定抑菌带的直径。结果:浓度为6.25%、12.5%、25%、50%和阳性对照时,平均抑菌带直径分别为4.80 mm、10.99 mm、16.83 mm、19.14 mm、29、80 mm。Kruskal Wallis检验显示,抑制区直径对嗜酸乳杆菌生长的抑制差异显著p = 0,000321 (p <0.05)。Man whitney试验表明,6.25%浓度与25%、50%浓度、12.5%浓度与25%、50%浓度之间存在显著性差异。6.25%与12.5%、25%与50%肉桂皮提取物对嗜酸乳杆菌的生长均有显著影响。结论:不同浓度肉桂皮提取物对嗜酸乳杆菌的生长均有抑制带直径的影响。25%的浓度是能显著抑制细菌的最低浓度
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引用次数: 0
Antidiarrheal Effect of Lime Peel Extract on Bisacodyl-Induced Mice 青柠皮提取物对比沙可的止泻作用
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.32144
Abraham Talent Bawadi Sibarani, Hesti Triwahyu Hutami, Nani Maharani, Y. Nindita
Background: Diarrhea is a condition of increased fecal water content of more than 200 grams or 200 ml/24 hours with a liquid or semi-liquid consistency. Complications of diarrhea, dehydration and malnutrition are still world health problems. Lime peel extract contains tannins which have astringent properties. Tannins are indicated as an alternative anti-diarrheal agent by tightening and forming a protective layer on the intestinal mucosa thereby reducing osmolarity.Aim: To examine the consistency, fecal water content, and frequency of defecation of bisacodyl-induced diarrhea in mice that are given lime peel extract.Methods: This research was an experimental with post test only group design. Thirty-six male mice were included and then divided into 5 groups with bisacodyl induction and 1 normal control group (KM) without bisacodyl induction. The negative control group (KN) was given 0.5 ml Tween 80 1%, the positive control group (KP) was given attalpugite 0.4 mg/40gW, treatment group 1 (X1), treatment group 2 (X2), treatment group 3 (X3 ) were given lime peel extract at graded doses of 125, 250, and 500 mg/KgW. Consistency, fecal water content, and frequency of defecation were observed every 30 minutes for 4 hours by observing the consistency of feces, weighing wet and dry feces to measure the water content, and measuring the frequency of defecation in each group. Data were analyzed statitiscally using Kruskal Wallis test with Post Hoc Mann Whitney test.Results: There were significant differences between the comparison of defecation frequency in the X3 group and the KM group, for the fecal water content comparison between the X3 group and the KN group, and no significant differences in the following group comparisons.Conclusion: Lime peel extract cannot reduce the frequency of defecation, fecal water content, and increase the consistency of feces significantly.Keywords: Diarrhea, lime peel extract, tannins, astringent, consistency, fecal water content, frequency of defecation.
背景:腹泻是粪便含水量增加超过200克或200毫升/24小时,呈液体或半液体状。腹泻、脱水和营养不良并发症仍然是世界卫生问题。酸橙皮提取物含有单宁,具有收敛性。单宁通过在肠粘膜上收紧和形成保护层从而降低渗透压,被认为是一种替代的抗腹泻剂。目的:观察灌胃青柠皮提取物后比沙可啶致腹泻小鼠的稠度、粪便含水量和排便次数。方法:本研究采用单纯后测组设计。选取雄性小鼠36只,分为5组双羟基乙酸乙酯诱导组和1组非双羟基乙酸乙酯正常对照组。阴性对照组(KN)给予Tween 80 % 0.5 ml,阳性对照组(KP)给予阿滑石0.4 mg/40gW,治疗组1 (X1)、治疗组2 (X2)、治疗组3 (X3)给予石灰皮提取物,剂量依次为125、250、500 mg/KgW。每隔30分钟观察一次粪便稠度、粪便含水量、排便次数,连续4 h,测量各组粪便稠度,称量干湿粪便含水量,测量排便次数。采用Kruskal Wallis检验和Post Hoc Mann Whitney检验对数据进行统计学分析。结果:X3组排便次数与KM组比较差异有统计学意义,粪便含水率与KN组比较差异无统计学意义,其余各组比较差异无统计学意义。结论:青柠皮提取物不能显著降低排便次数、降低粪便含水量、增加粪便粘稠度。关键词:腹泻,酸橙皮提取物,单宁,收敛,稠度,粪便含水量,排便次数。
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引用次数: 2
The Association between Face Mask Use and Headache: A Challenge in the New Normal Era 口罩使用与头痛的关系:新常态下的挑战
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.32104
Wira Dharma Utama, Erlina Purnamayani
Abstract Background: Indonesia has entered a new normal in the Covid-19 era and implemented strict health protocols in day-to-day activities. Transportation sectors, including air transportation, have been allowed to continue their services as long as they follow the health protocols, such as the mandatory use of face masks. Unfortunately, face masks now deal with several negative health issues, e.g., headache.Objective: To observe the association between face mask use and headache among airport officers and the average degree of the headache experience.Methods: The study was conducted at the Sultan Mahmud Badaruddin II (SMB II) International Airport in Palembang. The data were collected by a questionnaire gathered from December 2020 to January 2021. The data were processed using a quantitative approach with analytical methods.Results: From 207 airport officers, the major characteristics were female (57.9%), indoor workplaces (78.3%), face masks use ≤ 4 (four) hours per day (58.9%), and no headaches while using face masks (70.1%). There was a significant relationship between headache and face masks used > 4 hours per day (p < 0.001; 95% CI = 6.201 {3.215-11.958}). The mean of headaches degree using the VAS score was 2.3 (scale 0 - 10).Conclusion: Headaches could result from wearing facemasks for more than 4 hours per day. The mean degree of headaches due to facemasks used was relatively mild. The present research suggests that face masks must not cause other health problems. Improvement in face masks is the key to facing the Covid-19 pandemic and as important as washing hands and physical distancing.Keywords: Face mask; Headache; VAS Score
背景:印尼进入新冠肺炎疫情新常态,在日常活动中实施严格的卫生规程。交通运输部门,包括航空运输部门,只要遵守卫生议定书,例如强制使用口罩,就可以继续提供服务。不幸的是,口罩现在要处理一些负面的健康问题,例如头痛。目的:观察机场工作人员口罩使用与头痛的关系及平均头痛程度。方法:研究在巨港苏丹马哈茂德巴达鲁丁二世(SMB II)国际机场进行。数据是通过2020年12月至2021年1月收集的问卷收集的。数据采用定量分析方法处理。结果:207名机场工作人员的主要特征为女性(57.9%)、室内工作(78.3%)、每天使用口罩≤4(4)小时(58.9%)、使用口罩时不头痛(70.1%)。每天使用口罩> 4小时与头痛有显著关系(p < 0.001;95% ci = 6.201{3.215-11.958})。使用VAS评分的头痛程度平均值为2.3(评分范围0 - 10)。结论:每天戴口罩超过4小时可能导致头痛。使用口罩引起的平均头痛程度相对较轻。目前的研究表明,口罩一定不会造成其他健康问题。改进口罩是应对Covid-19大流行的关键,与洗手和保持身体距离一样重要。关键词:口罩;头痛;脉管得分
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引用次数: 0
Acute COVID-19 cardiovascular syndrome: A case report 急性COVID-19心血管综合征1例报告
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.30323
Agus Layanto, S. R. Addin, Friska Anggraini Helena Silitonga, A. Nurani, Rakhma Yanti Hellmi, Charles Limantoro, K. Seno, Fathur Nur Kholis
A man 44 years old with metabolic syndrome and chronic kidney disease was presenting acute COVID-19 cardiovascular syndrome. The condition was aggravated by presence of ureterolithiasis and gout. After treatment, hemodialysis and ureteroscopic lithotripsy-double J ureteral stent, the patient was recovered from his condition
44岁男性合并代谢综合征和慢性肾脏疾病,出现急性COVID-19心血管综合征。输尿管结石和痛风加重了病情。经血液透析及输尿管镜碎石+双J输尿管支架治疗后,患者痊愈
{"title":"Acute COVID-19 cardiovascular syndrome: A case report","authors":"Agus Layanto, S. R. Addin, Friska Anggraini Helena Silitonga, A. Nurani, Rakhma Yanti Hellmi, Charles Limantoro, K. Seno, Fathur Nur Kholis","doi":"10.14710/dmj.v10i6.30323","DOIUrl":"https://doi.org/10.14710/dmj.v10i6.30323","url":null,"abstract":"A man 44 years old with metabolic syndrome and chronic kidney disease was presenting acute COVID-19 cardiovascular syndrome. The condition was aggravated by presence of ureterolithiasis and gout. After treatment, hemodialysis and ureteroscopic lithotripsy-double J ureteral stent, the patient was recovered from his condition","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124791291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Sleep Quality and Working Memory of Medical Faculty Malikussaleh University Students 马利库沙勒大学医学院学生睡眠质量与工作记忆的关系
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.32145
Amri Afra Adilla, Cut Khairunnisa, Cut Sidrah Nadira, Rizka Sofia
Background: Working memory is a form of storage of information that is relevant to the activity being worked out in a short time and a limited amount of information. The working memory capacity is influenced by sleep quality. Increased human activity in the modern era, causing less attention to the quality and quantity of sleep. Recent study showed that the prevalence of medical student who have poor sleep quality is quite high, reaching 76%. Poor quality of sleep will cause a person to think and work more slowly, make mistakes, and have a hard time remembering things. Objective: This research aims to know the relationship of sleep quality with working memory capacity in medical students of Malikussaleh University. Methods: This research was an analytical study with cross- sectional approach, and the Fisher test was used as the statistical test. Proportional stratified random sampling was used to  obtained  71 samples of students who had qualified inclusion and exclusion criterias. Results: The results showed that 84,5% of students had poor quality of sleep and 56,3% of students had low working memory capacity. Statistical analysis by Fisher test showed the value of p < 0,05. Conclusion:  there is an association between sleep quality and the capacity of working memory in the Faculty of Medicine students of Malikussaleh University.
背景:工作记忆是一种存储信息的形式,这些信息与在短时间内和有限数量的信息中进行的活动有关。工作记忆容量受睡眠质量的影响。现代人类活动的增加,导致人们对睡眠质量和数量的关注减少。最近的研究表明,医学生睡眠质量差的患病率相当高,达到76%。睡眠质量差会导致一个人思考和工作更慢,犯错误,并且很难记住事情。目的:了解马利库萨勒大学医学生睡眠质量与工作记忆容量的关系。方法:本研究采用横断面分析方法,统计检验采用Fisher检验。采用比例分层随机抽样法,获得符合纳入标准和排除标准的学生样本71份。结果:84.5%的学生睡眠质量较差,56.3%的学生工作记忆容量较低。经Fisher检验,p < 0.05。结论:马利库萨勒大学医学院学生的睡眠质量与工作记忆容量存在相关性。
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引用次数: 1
Correlation between Body Mass Index, Muscle Mass, and Muscle Explosive Power in First-Year Medical Students of Diponegoro University 迪波内戈罗大学医一年级学生体重指数、肌肉质量和肌肉爆发力的相关性研究
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.31687
Devi Wahyu Arum sari, Hafizhil Uzhma Al Ahmadi, T. Jordan, Buwono Puruhito, Edwin Basyar, Darmawati Ayu Indraswari
Abstract Background: Muscle explosive power as a component of physical fitness is an important factor that supports athletic performance in most sports. jump height and vertical jump performance in assessing explosive muscle power are influenced by various factors, including physiological, biomechanical, and anthropometric factors. Body mass index, muscle mass, and fat mass are important anthropometric factors in supporting jumping performance.Objective: To analyze the relationship between body mass index and muscle mass with legs muscle explosive power in first-year medical students of Diponegoro University.Methods: This study is an observational analytic study with a cross-sectional design. The subjects consist of 60 males and 108 females in first-year medical students of Diponegoro University who met the criteria. Body mass index and muscle mass were measured by Omron bioelectrical impedance analyzer, and muscle explosive power was measured by vertical jump test. Data were analyzed with the Kolmogorov Smirnov normality test and Spearman correlation test.Results: The average value of body mass index was 21.760±2.7734, muscle mass was 29.468±4.3283, and muscle explosive power was 29.468±4.3283. Muscle mass was positively correlated with legs muscle explosive power (p=0.00, R= 0.583) and negatively correlated between body mass index and legs muscle explosive power but it was not statistically significant (p=0.823 dan R=- 0.017) in first-year medical students of Diponegoro University.Conclusion: Muscle mass was positively correlated with legs muscle explosive power and body mass index showed no significant correlation with muscle explosive power. Keywords: body mass index, muscle explosive power, muscle mass, vertical jump test
摘要背景:在大多数运动中,肌肉爆发力作为体能的组成部分是支持运动成绩的重要因素。在评估爆发力时,起跳高度和垂直起跳表现受到多种因素的影响,包括生理学、生物力学和人体测量学因素。身体质量指数、肌肉质量和脂肪质量是支持跳跃表现的重要人体测量因素。目的:分析狄波尼哥罗大学医一年级学生体重指数、肌肉质量与腿部肌肉爆发力的关系。方法:采用横断面设计的观察性分析研究。研究对象包括符合标准的迪波涅戈罗大学医学院一年级学生60名男性和108名女性。用欧姆龙生物电阻抗分析仪测定体重指数和肌肉质量,用垂直跳跃试验测定肌肉爆发力。采用Kolmogorov - Smirnov正态性检验和Spearman相关检验对数据进行分析。结果:体重指数平均值为21.760±2.7734,肌肉质量平均值为29.468±4.3283,肌肉爆发力平均值为29.468±4.3283。迪波内戈罗大学医一年级学生的肌肉质量与腿部肌肉爆发力呈正相关(p=0.00, R= 0.583),体重指数与腿部肌肉爆发力呈负相关(p=0.823, R=- 0.017),但差异无统计学意义(p=0.823, R=- 0.017)。结论:肌肉质量与腿部肌肉爆发力呈正相关,体质量指数与肌肉爆发力无显著相关。关键词:体重指数,肌肉爆发力,肌肉质量,垂直跳跃试验
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引用次数: 3
POTENTIAL USE OF VIRTUAL REALITY IN OVERCOMING NEEDLE PHOBIA IN COVID-19 VACCINATION 虚拟现实在COVID-19疫苗接种中克服针头恐惧症的潜在应用
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.31504
P. M. Herlambang, N. Wiyono, Hendry Gunawan, Rani Tiyas Budiyanti
Background: Vaccination is very important because it can help prevent diseases that can be prevented by immunization (PD3I) such as polio, tetanus, diphtheria, measles, mumps, and rubella. During the Coronavirus Disease -19 (COVID-19) pandemic, the role of vaccination is very crucial, especially to reach herd immunity. However, there are many problems related to the implementation of vaccination, including needle phobia, which is a phobia of needles because it is considered painful. Virtual reality is a technology that develops in the form of a virtual image that can be used in vaccination services. This study aims to determine the potency of virtual reality to solve the needle phobia in vaccination services.Methods: The method used in this study is a literature review with sources from journals in the Scopus, ProQuest, and ScienceDirect database that was published in 2000 until 2020, and also books and articles with the keywords "virtual reality" "AND" "immunization," virtual reality " AND " vaccination " , "Needle phobia" "AND" "vaccination". This research was conducted from January to February 2021.Results: Based on the results obtained, virtual reality can be used in vaccination services, especially in the treatment of needle phobia. Virtual reality can become a distraction so that the patient will be distracted from fear and can lower the pain threshold. In addition, virtual reality can also be used as a means of education about immunization.Conclusion: Product development and clinical research need to be developed to assess the use of virtual reality in vaccination services during the COVID-19 pandemic. The use of virtual reality for other medical procedures that use needles can also be further investigated
背景:疫苗接种非常重要,因为它有助于预防可通过免疫预防的疾病(PD3I),如脊髓灰质炎、破伤风、白喉、麻疹、腮腺炎和风疹。在2019冠状病毒病(COVID-19)大流行期间,疫苗接种的作用非常重要,特别是在实现群体免疫方面。然而,与疫苗接种的实施有关的问题很多,包括针恐惧症,这是一种对针的恐惧,因为它被认为是痛苦的。虚拟现实是一种以虚拟图像形式发展的技术,可用于疫苗接种服务。本研究旨在确定虚拟现实在解决疫苗接种服务中的针恐惧症方面的效力。方法:本研究采用文献综述的方法,检索Scopus、ProQuest和ScienceDirect数据库2000年至2020年出版的期刊,以及关键词为“虚拟现实”“与”“免疫”、“虚拟现实”“与”“疫苗接种”、“针恐惧症”“与”“疫苗接种”的书籍和文章。该研究于2021年1月至2月进行。结果:基于所获得的结果,虚拟现实可用于疫苗接种服务,特别是针恐惧症的治疗。虚拟现实可以分散病人的注意力,使他们从恐惧中分散注意力,从而降低疼痛阈值。此外,虚拟现实还可以作为免疫教育的一种手段。结论:需要开展产品开发和临床研究,以评估COVID-19大流行期间虚拟现实在疫苗接种服务中的使用情况。在使用针头的其他医疗程序中使用虚拟现实也可以进一步研究
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引用次数: 2
FACTORS ASSOCIATED WITH MEDICATION ADHERENCE IN HYPERTENSION IN THE NGLUWAR PUBLIC HEALTH CENTER IN MAGELANG REGENCY 马格朗县ngluwar公共卫生中心高血压患者药物依从性的相关因素
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.31477
Taufan Agung Wicaksono, A. Nugraheni, Firdaus Wahyudi, P. Ardhianto
Background: Adherence is an important matter in the succession of hypertension medication. Despite the fact, it was found that many with hypertension had not used antihypertension medications as prescribed.Objective: To acknowledge the factors correlated to antihypertension medication adherence.Method: We used an observational, cross-sectional study model with a quantitative analytical approach. Some 131 qualified hypertensive patients of Ngluwar Public Health Center were recruited in February and March of 2021. A sampling method of purposive sampling was used. The data obtained were statistically analyzed using the chi-square test. Results: Eighty-two respondents (62.6%) had high medication adherence and 49 respondents (37.4%) were low at medication adherence. The statistical analysis results are as follows. Level of education (p = 0.374, PR = 1.264, CI 95% = 0.765-2.090), job status (p = 0.025, PR = 0.591, CI 95% = 0.367-0.953), comorbidity (p = 0.366, PR = 1.239, CI 95% = 0.772-1.988), duration of hypertension (p = 0.604, PR = 1.124, CI 95% = 0.722-1.751), family support (p = 0.142, PR = 1.396, CI 95% = 0.890-2.190), health worker support (p = 0.002, PR = 1.994, CI 95% = 1.313-3.028), affordability (p = 0.329, PR = 1.246, CI 95% = 0.802-1.937) and accessibility (p = 0.564, PR = 1.240, CI 95% = 0.623-2.468), and polypharmacy (p = 0.573, PR = 0.848, CI 95% = 0.488-1.474).Conclusion: Job status and health worker support were significantly correlated to antihypertensive medication adherence.
背景:依从性是高血压药物治疗的一个重要方面。尽管如此,研究发现许多高血压患者并没有按照规定服用抗高血压药物。目的:了解影响降压药物依从性的相关因素。方法:采用定量分析方法的观察性横断面研究模型。于2021年2月和3月在恩格瓦尔公共卫生中心招募了131名符合条件的高血压患者。采用目的抽样的抽样方法。所得资料采用卡方检验进行统计学分析。结果:高依从性的有82例(62.6%),低依从性的有49例(37.4%)。统计分析结果如下:教育水平(p = 0.374,公关= 1.264,95% CI -2.090 = 0.765),工作状态(p = 0.025,公关= 0.591,95% CI -0.953 = 0.367),并发症(p = 0.366,公关= 1.239,95% CI -1.988 = 0.772),期间高血压(p = 0.604,公关= 1.124,95% CI -1.751 = 0.722),家庭支持(p = 0.142,公关= 1.396,95% CI -2.190 = 0.890),卫生工作者的支持(p = 0.002,公关= 1.994,95% CI = 1.313 - -3.028),支付能力(p = 0.329,公关= 1.246,95% CI = 0.802 - -1.937)和可访问性(p = 0.564,公关= 1.240,CI 95% = 0.623-2.468)和多药(p = 0.573, PR = 0.848, CI 95% = 0.488-1.474)。结论:工作状态和卫生工作者支持与降压药物依从性显著相关。
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引用次数: 2
The Effect of Radiotherapy on Blood Components of Cervical Cancer Patients 放疗对宫颈癌患者血液成分的影响
Pub Date : 2021-11-30 DOI: 10.14710/dmj.v10i6.30411
Afina Yuliani Putri, Yan Wisnu Prajoko, J. Dewantiningrum, C. Prihharsanti
Background: Radiotherapy exposure is known to have a lethal effect on blood cells because hematopoietic cells are very sensitive to radiation exposure even at low doses. Cervical cancer with radiotherapy can have the effect of reducing blood cells. Blood cells that may experience the effects of radiotherapy include haemoglobin, leukocytes and platelets.Objective: Knowing the effects of radiotherapy towards blood components of cervical cancer patients.Methods: This study was an observational study with the type of study before and after design. Data collected from medical records as secondary data in the Radiotherapy Unit of Dr. Kariadi Semarang in 2019-2020 with a total of 128 cervical cancer patients undergoing 3D radiotherapy. The statistical test used the Saphiro Wilk data normality test and the result data analysis used the Paired T Test and the Wilcoxon test.Results: Hypothesis testing for Hb levels using the Paired T Test showed an insignificant value of p=0.749 and p=0.141. Hypothesis test for the number of leukocytes and platelets using the Wilcoxon test. Leukocytes received a significant value of p=0.000 and insignificant p=0.957. Platelets received a significant value of p=0.000 and p=0.000. Hb value decreased by -0.44, leukocytes by -3.5, and platelets by -84.34.Conclusion: There was an insignificant decrease in haemoglobin levels yet significant decrease in leukocyte and platelet counts in cervical cancer patients undergoing radiotherapy where the platelets experienced the most decrease compared to haemoglobin and leukocytes.
背景:放射治疗暴露已知对血细胞有致命影响,因为造血细胞对低剂量辐射暴露非常敏感。宫颈癌放射治疗可起到减少血细胞的作用。可能受到放射治疗影响的血细胞包括血红蛋白、白细胞和血小板。目的:了解放疗对宫颈癌患者血液成分的影响。方法:本研究为观察性研究,采用前后设计的研究类型。从医疗记录中收集的数据,作为2019-2020年Kariadi Semarang博士放射治疗部门的次要数据,共有128名宫颈癌患者接受了3D放射治疗。统计检验采用sapiro Wilk数据正态性检验,结果数据分析采用配对T检验和Wilcoxon检验。结果:使用配对T检验对Hb水平进行假设检验,p=0.749和p=0.141的值不显著。使用Wilcoxon检验对白细胞和血小板数量进行假设检验。白细胞的显著值p=0.000,不显著值p=0.957。血小板得到显著值p=0.000和p=0.000。Hb值下降-0.44,白细胞下降-3.5,血小板下降-84.34。结论:宫颈癌放疗患者血红蛋白水平下降不明显,但白细胞和血小板计数明显下降,其中血小板比血红蛋白和白细胞减少最多。
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DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)
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