Pub Date : 2022-01-29DOI: 10.14710/dmj.v11i1.32666
Debie Rizqoh, Enny Nugrahaeni, Jusup Endang, M. Sundari, Dessy Triana, M. Sariyanti, Nikki Aldi Massardi
Background: The COVID-19 pandemic is still ongoing, and no one could predict when it would end. In some cases of COVID-19, patients experienced infection by SARS-Cov-2 and other microorganisms, including viruses, bacteria, and fungi.Objective: This study aims to determine Co-infection on clinical symptoms and mortality of COVID-19 patients in Bengkulu City, Indonesia.Methods: We reviewed and analyzed data on patients with confirmed COVID-19 who were co-infected, including basic information, clinical manifestations, radiological and laboratory examinations, to the final status.Results: A total of 105 patients with confirmed COVID-19 participated in this study with various clinical manifestation: mild case (12%), moderate case/ mild pneumonia (52%), severe pneumonia (20%) and critical case (16%). Of the 105 patients, six patients were co-infected with human immunodeficiency virus (HIV) (1 case), Mycobacterium tuberculosis (2 cases), Salmonella thypii (2 cases), bacterial pneumonia, and viral pneumonia (1 case). As many as three of the six patients experienced inferior clinical manifestations and died.Conclusion: The co-infection of other microorganisms in COVID-19 can affect the severity and mortality in COVID-19 patients.
{"title":"CLINICAL MANIFESTATION OF COVID-19 CO-INFECTION CASE IN BENGKULU CITY","authors":"Debie Rizqoh, Enny Nugrahaeni, Jusup Endang, M. Sundari, Dessy Triana, M. Sariyanti, Nikki Aldi Massardi","doi":"10.14710/dmj.v11i1.32666","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.32666","url":null,"abstract":"Background: The COVID-19 pandemic is still ongoing, and no one could predict when it would end. In some cases of COVID-19, patients experienced infection by SARS-Cov-2 and other microorganisms, including viruses, bacteria, and fungi.Objective: This study aims to determine Co-infection on clinical symptoms and mortality of COVID-19 patients in Bengkulu City, Indonesia.Methods: We reviewed and analyzed data on patients with confirmed COVID-19 who were co-infected, including basic information, clinical manifestations, radiological and laboratory examinations, to the final status.Results: A total of 105 patients with confirmed COVID-19 participated in this study with various clinical manifestation: mild case (12%), moderate case/ mild pneumonia (52%), severe pneumonia (20%) and critical case (16%). Of the 105 patients, six patients were co-infected with human immunodeficiency virus (HIV) (1 case), Mycobacterium tuberculosis (2 cases), Salmonella thypii (2 cases), bacterial pneumonia, and viral pneumonia (1 case). As many as three of the six patients experienced inferior clinical manifestations and died.Conclusion: The co-infection of other microorganisms in COVID-19 can affect the severity and mortality in COVID-19 patients.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124660162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-29DOI: 10.14710/dmj.v11i1.32715
Muhammad Aditya Pradana, E. K. S. Limijadi, Kusmiyati- Tjahjono, Banundari Rachmawati
Background: Diabetes Mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels above the normal range. Type-2 diabetes mellitus can cause lipid metabolism disorder. This study analyzed the relationship between fasting blood glucose and LDL cholesterol levels in type-2 diabetes mellitus patients.Aim: To prove the correlation between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus.Methods: This research is an observational analytical study with cross-sectional design on 40 subjects. The secondary data for this research was obtained from diabetic patients at Diponegoro National Hospital. The correlation analysis was done using Spearman Rank test.Results: Spearman Rank analysis showed no significant association between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus (p = 0,119 and r = 0,250).Conclusion: There was no significant correlation between fasting blood glucose levels with LDL cholesterol levels in patients with Type-2 Diabetes Mellitus.
背景:糖尿病是一种以血糖水平高于正常范围为特征的慢性代谢性疾病。2型糖尿病可引起脂质代谢紊乱。本研究分析了2型糖尿病患者空腹血糖与低密度脂蛋白胆固醇水平的关系。目的:探讨2型糖尿病患者空腹血糖水平与低密度脂蛋白胆固醇水平的相关性。方法:采用横断面设计的观察性分析研究。本研究的次要数据来自迪波尼戈罗国立医院的糖尿病患者。相关分析采用Spearman Rank检验。结果:Spearman Rank分析显示，2型糖尿病患者空腹血糖水平与LDL胆固醇水平无显著相关性(p = 0,119, r = 0,250)。结论:2型糖尿病患者空腹血糖水平与低密度脂蛋白胆固醇水平无显著相关性。
{"title":"RELATIONSHIP BETWEEN FASTING BLOOD GLUCOSE LEVELS AND LDL CHOLESTEROL LEVELS IN PATIENTS WITH TYPE-2 DIABETES MELLITUS IN DIPONEGORO NATIONAL HOSPITAL","authors":"Muhammad Aditya Pradana, E. K. S. Limijadi, Kusmiyati- Tjahjono, Banundari Rachmawati","doi":"10.14710/dmj.v11i1.32715","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.32715","url":null,"abstract":"Background: Diabetes Mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels above the normal range. Type-2 diabetes mellitus can cause lipid metabolism disorder. This study analyzed the relationship between fasting blood glucose and LDL cholesterol levels in type-2 diabetes mellitus patients.Aim: To prove the correlation between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus.Methods: This research is an observational analytical study with cross-sectional design on 40 subjects. The secondary data for this research was obtained from diabetic patients at Diponegoro National Hospital. The correlation analysis was done using Spearman Rank test.Results: Spearman Rank analysis showed no significant association between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus (p = 0,119 and r = 0,250).Conclusion: There was no significant correlation between fasting blood glucose levels with LDL cholesterol levels in patients with Type-2 Diabetes Mellitus.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129791863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-29DOI: 10.14710/dmj.v11i1.31224
Gabriela Rolanda, L. Batubara, I. Saraswati, Kusmiyati-Tjahjono Dk
Background: Cigarettes increase cardiovascular risks by modifying lipid profiles through oxidation, alternating lipoprotein composition, and fat metabolizing enzyme activity. Vascular dysfunction can primarily identified by LDL cholesterol composition shift, one of atherosclerosis predictor. Rosella is a multifunctional herb that widely used as a pleasant tea. Aside from its rich components, anthocyanin, pectin, PCA and hibiscus acid are playing the role keys in lowering LDL cholesterol through lipid metabolism enzyme activity modification. Rosella is easy to find, relatively cheap, tasteful and also categorized as food-grade FDA approved.Aim: To investigate the effect of rosella infusion in decreasing LDL cholesterol serum on cigarettes exposed male Sprague dawley rat.Methods: This study is a true experimental study design with post-test only controlled group design. After 7 days of adaptation, a total of 30 male Sprague dawley rats were randomly divided into 5 groups (n=6 per group); KN received no special treatment; KP exposed to 4 rods of cigarette smoke/day; experimental groups (P1, P2, P3) exposed to 4 rods of cigarette smoke/day and rosella dried calyx infusion with 250, 500 and 1000 mg/kg respectively for 30 consecutive days. LDL cholesterol levels are measured using the CHOD-PAP method. Collected data were analyzed statistically using One Way ANOVA Test.Results: There is a significant difference between all experimental groups (p=0,00) in the post-hoc test.Conclusion: These lines of evidence suggest that rosella infusion significantly decreases LDL Cholesterol serum level in cigarettes exposed Sprague dawley rats in a dose-dependent manner.Keywords: Cigarettes smoke, LDL cholesterol, Rosella calyx infusion
{"title":"THE EFFECT OF ROSELLA DRIED CALYX INFUSION (HIBISCUS SABDARIFFA) IN LOWERING LDL CHOLESTEROL SERUM LEVEL ON CIGARETTE SMOKE EXPOSED MALE SPRAGUE DAWLEY RATS","authors":"Gabriela Rolanda, L. Batubara, I. Saraswati, Kusmiyati-Tjahjono Dk","doi":"10.14710/dmj.v11i1.31224","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.31224","url":null,"abstract":"Background: Cigarettes increase cardiovascular risks by modifying lipid profiles through oxidation, alternating lipoprotein composition, and fat metabolizing enzyme activity. Vascular dysfunction can primarily identified by LDL cholesterol composition shift, one of atherosclerosis predictor. Rosella is a multifunctional herb that widely used as a pleasant tea. Aside from its rich components, anthocyanin, pectin, PCA and hibiscus acid are playing the role keys in lowering LDL cholesterol through lipid metabolism enzyme activity modification. Rosella is easy to find, relatively cheap, tasteful and also categorized as food-grade FDA approved.Aim: To investigate the effect of rosella infusion in decreasing LDL cholesterol serum on cigarettes exposed male Sprague dawley rat.Methods: This study is a true experimental study design with post-test only controlled group design. After 7 days of adaptation, a total of 30 male Sprague dawley rats were randomly divided into 5 groups (n=6 per group); KN received no special treatment; KP exposed to 4 rods of cigarette smoke/day; experimental groups (P1, P2, P3) exposed to 4 rods of cigarette smoke/day and rosella dried calyx infusion with 250, 500 and 1000 mg/kg respectively for 30 consecutive days. LDL cholesterol levels are measured using the CHOD-PAP method. Collected data were analyzed statistically using One Way ANOVA Test.Results: There is a significant difference between all experimental groups (p=0,00) in the post-hoc test.Conclusion: These lines of evidence suggest that rosella infusion significantly decreases LDL Cholesterol serum level in cigarettes exposed Sprague dawley rats in a dose-dependent manner.Keywords: Cigarettes smoke, LDL cholesterol, Rosella calyx infusion","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124131542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-29DOI: 10.14710/dmj.v11i1.31482
Nopiane Rospita Ingan Ergani, Friska Anggraini Helena
Background: Heart failure is when the heart cannot pump enough blood to fulfill the body's needs. This disease is dangerous and can lead to death. The most common risk factors are hypertension, diabetes mellitus, and metabolic syndrome.Case Presentation: A 54-year-old man complained of shortness of breath for the last one month, which worsened during light activities and decreased when he was in a semi-sitting position. The patient had a history of hypertension and type-II diabetes mellitus for the last five years. On physical examination, the patient's blood pressure was 140/100 mmHg, respiratory rate was 25 bpm. There were paroxysmal nocturnal dyspnea, orthopnea, rales on both basal lung fields, dyspnea on exertion, ankle edema, a pansystolic murmur heard in the apex, ascites and ankle edema. Blood laboratory examination showed HbA1c 6%, chest X-ray and ECG showed cardiomegaly.Conclusion: The patient was diagnosed with NYHA Class III Heart Failure with stage 2 hypertension and type-2 diabetes mellitus and was treated with fluids, diuretics, ACE inhibitors, beta-blockers, low salt diet, restriction of fluid intake, and oral antidiabetics.
{"title":"A CASE STUDY OF A 54-YEAR-OLD MAN WITH NYHA CLASS III, STAGE 2 HYPERTENSION, AND TYPE II DIABETES MELLITUS","authors":"Nopiane Rospita Ingan Ergani, Friska Anggraini Helena","doi":"10.14710/dmj.v11i1.31482","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.31482","url":null,"abstract":"Background: Heart failure is when the heart cannot pump enough blood to fulfill the body's needs. This disease is dangerous and can lead to death. The most common risk factors are hypertension, diabetes mellitus, and metabolic syndrome.Case Presentation: A 54-year-old man complained of shortness of breath for the last one month, which worsened during light activities and decreased when he was in a semi-sitting position. The patient had a history of hypertension and type-II diabetes mellitus for the last five years. On physical examination, the patient's blood pressure was 140/100 mmHg, respiratory rate was 25 bpm. There were paroxysmal nocturnal dyspnea, orthopnea, rales on both basal lung fields, dyspnea on exertion, ankle edema, a pansystolic murmur heard in the apex, ascites and ankle edema. Blood laboratory examination showed HbA1c 6%, chest X-ray and ECG showed cardiomegaly.Conclusion: The patient was diagnosed with NYHA Class III Heart Failure with stage 2 hypertension and type-2 diabetes mellitus and was treated with fluids, diuretics, ACE inhibitors, beta-blockers, low salt diet, restriction of fluid intake, and oral antidiabetics.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131849890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: WHO estimates more than 150 million diabetes patients worldwide. One of the complications of diabetes is diabetic retinopathy which is recognized as the leading cause of blindness in the working-age population and the cause of 12% of new cases of blindness each year due to macular edema, vitreous hemorrhage, and tractional retinal detachment. Macular edema is the most common cause of decreased visual acuity. The relationship between macular edema and the degree of retinopathy is unclear, so further research is needed. This study aimed to analyze the incidence of macular edema with the degree of diabetic retinopathy.METHOD: This study used a cross-sectional method. Samples were taken from the Retina Data Register at the National Diponegoro Hospital Eye Polyclinic of all diabetic retinopathy patients who attended National Diponegoro Hospital from July to December 2020 who were recruited as participants. The variables measured included the incidence of macular edema and the degree of diabetic retinopathy. Measurements using fundoscopy, slit lamp and condensing lens + 78D according to ETDRS (Early Treatment Diabetic Retinopathy Study) criteria by an ophthalmologist. Data analysis used a bivariate difference test for 2 groups. The statistical test used was the Kruskal-Wallis test, which was significant if p ≤ 0.05.RESULTS: In this study, out of 150 eyes examined, 28 (18.7%) had macular edema. 4 (2.7%) eyes were diagnosed with Moderate NPDR, 3 (2%) eyes were diagnosed with Severe NPDR. In eyes diagnosed with PDR with or without VH or TRD, 21 (14%) eyes had macular edema. The p-value was 0.03 with the Kruskal-Wallis test, where p ≤ 0.05.CONCLUSION: There is a significant difference between the degree of diabetic retinopathy and the incidence of macular edema. The incidence of macular edema is higher in the more severe degrees of diabetic retinopathy.
{"title":"ASSOCIATION BETWEEN THE DEGREE OF DIABETIC RETINOPATHY AND DIABETIC MACULAR EDEMA","authors":"Andhika Guna Dharma, Maharani Maharani, Riski Prihatningtias, Muhamad Taufik Mahar, Henry Setiawan, Ayu Anggraini Kusumaningrum, Arief Wildan","doi":"10.14710/dmj.v11i1.30840","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.30840","url":null,"abstract":"INTRODUCTION: WHO estimates more than 150 million diabetes patients worldwide. One of the complications of diabetes is diabetic retinopathy which is recognized as the leading cause of blindness in the working-age population and the cause of 12% of new cases of blindness each year due to macular edema, vitreous hemorrhage, and tractional retinal detachment. Macular edema is the most common cause of decreased visual acuity. The relationship between macular edema and the degree of retinopathy is unclear, so further research is needed. This study aimed to analyze the incidence of macular edema with the degree of diabetic retinopathy.METHOD: This study used a cross-sectional method. Samples were taken from the Retina Data Register at the National Diponegoro Hospital Eye Polyclinic of all diabetic retinopathy patients who attended National Diponegoro Hospital from July to December 2020 who were recruited as participants. The variables measured included the incidence of macular edema and the degree of diabetic retinopathy. Measurements using fundoscopy, slit lamp and condensing lens + 78D according to ETDRS (Early Treatment Diabetic Retinopathy Study) criteria by an ophthalmologist. Data analysis used a bivariate difference test for 2 groups. The statistical test used was the Kruskal-Wallis test, which was significant if p ≤ 0.05.RESULTS: In this study, out of 150 eyes examined, 28 (18.7%) had macular edema. 4 (2.7%) eyes were diagnosed with Moderate NPDR, 3 (2%) eyes were diagnosed with Severe NPDR. In eyes diagnosed with PDR with or without VH or TRD, 21 (14%) eyes had macular edema. The p-value was 0.03 with the Kruskal-Wallis test, where p ≤ 0.05.CONCLUSION: There is a significant difference between the degree of diabetic retinopathy and the incidence of macular edema. The incidence of macular edema is higher in the more severe degrees of diabetic retinopathy.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130214110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-17DOI: 10.14710/dmj.v11i1.32588
A. Anastasia, H. Sukmaningtyas, Agus Priambodo, Erna Setiawati
Background: Osteoarthritis is a long-term, chronic disease that is usually marked by cartilage degeneration in the joints, which in turn induces bone friction. One of the subtype of this disease is facet joint osteoarthritis or in short, FJOA. In Indonesia, FJOA has not been commonly documented. The most common method for FJOA inspection is X-Ray modality. The usage of other radiology imaging, such as CT-Scan or MRI, are also used to evaluate erosion, osteophyte creation, subchondral sclerosis, and joint constriction. Nevertheless, the most ideal FJOA inspection method is still an ongoing debate due to strengths and weaknesses of each methods. CT scans are more widely used than MRIs and are typically less expensive. MRIs, however, are thought to be superior in regards to the detail of the image. Objective: To understand the effect of age, sex, and spinal level towards FJOA on MRI scanning. Method: This research used cross-sectional approach. Sample taken in this research were all radiology results from patients that fulfills inclusion criteria and had gone through MRI inspection in Jatinegara Premier Hospital. Age, sex, disk degeneration degree, and spinal level are the main focus for this study since those are the most common risk factor for FJOA. Results: 46.8% of FJOA were found in male patients while the other 53.2% were found in females. L4-5 and Grade 1 FJOA had the highest incidence found, with the amount of 29% and 48.4% respectively. There was no correlation between sex and FJOA degree based on Asymp. Sig of 0.255. There was also no correlation between age and FJOA degree based on Asymp. Sig of 0.702. However, there was a correlation between spinal level and disk degeneration degree with FJOA degree due to Asymp. Sig <0.05. Conclusion: There was no significant relationship between age and sex to lumbar facet joint osteoarthritis and there was a significant relationship between spinal level and disk degeneration degree with lumbar facet joint osteoarthritis.
{"title":"ANALYSIS OF RISK FACTORS AFFECTING LUMBAL FACET JOINT OSTEOARTHRITIS IN MRI SCAN","authors":"A. Anastasia, H. Sukmaningtyas, Agus Priambodo, Erna Setiawati","doi":"10.14710/dmj.v11i1.32588","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.32588","url":null,"abstract":"Background: Osteoarthritis is a long-term, chronic disease that is usually marked by cartilage degeneration in the joints, which in turn induces bone friction. One of the subtype of this disease is facet joint osteoarthritis or in short, FJOA. In Indonesia, FJOA has not been commonly documented. The most common method for FJOA inspection is X-Ray modality. The usage of other radiology imaging, such as CT-Scan or MRI, are also used to evaluate erosion, osteophyte creation, subchondral sclerosis, and joint constriction. Nevertheless, the most ideal FJOA inspection method is still an ongoing debate due to strengths and weaknesses of each methods. CT scans are more widely used than MRIs and are typically less expensive. MRIs, however, are thought to be superior in regards to the detail of the image. Objective: To understand the effect of age, sex, and spinal level towards FJOA on MRI scanning. Method: This research used cross-sectional approach. Sample taken in this research were all radiology results from patients that fulfills inclusion criteria and had gone through MRI inspection in Jatinegara Premier Hospital. Age, sex, disk degeneration degree, and spinal level are the main focus for this study since those are the most common risk factor for FJOA. Results: 46.8% of FJOA were found in male patients while the other 53.2% were found in females. L4-5 and Grade 1 FJOA had the highest incidence found, with the amount of 29% and 48.4% respectively. There was no correlation between sex and FJOA degree based on Asymp. Sig of 0.255. There was also no correlation between age and FJOA degree based on Asymp. Sig of 0.702. However, there was a correlation between spinal level and disk degeneration degree with FJOA degree due to Asymp. Sig <0.05. Conclusion: There was no significant relationship between age and sex to lumbar facet joint osteoarthritis and there was a significant relationship between spinal level and disk degeneration degree with lumbar facet joint osteoarthritis.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114485693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-17DOI: 10.14710/dmj.v11i1.31226
Ongky Surya Wijaya Hendro, Eka Yudhanto, A. Himawan, D. Adespin
Background: Cancer is a type of disease with a high rate of diagnostic cases. The real cause of cancer remains unknown. Free radicals can cause cancer by DNA’s gen mutation. 7, 12- Dimethylbenz[a]anthracene (DMBA) is often used for researching carcinogenesis. Many types of research have used natural substances as supportive cancer therapies including Momordica charantia (bitter melon). Malondialdehyde (MDA) is one of the oxidative damage biomarkers which can significantly increase, especially on breast cancer patients. The success of therapy on a breast cancer patient is shown by decreasing MDA levels in the blood. Aim: To investigate the effect of Momordica charantia fruit ethanolic extract on malondialdehyde levels in the blood of Sprague Dawley rats induced by 7,12- Dimethylbenz [a] anthracene. Methods: This study was a true experimental randomized post-test only with control group design on rats that divided into two groups: X1 given DMBA induction only and X2 given DMBA induction with Momordica charantia fruit ethanolic extract by feeding tube with 200mg/kgbw/day for 14 days. Results: The mean of MDA level in group X1 = 0,83±0,32 and in group X2 = 0,30±0,19. The result of the normality test of data using the Shapiro-Wilk test obtained abnormal distribution data for one of the groups. The result of independent-samples T-Test showed a significant difference with P = 0,001. Conclusion: There was an effect of Momordica charantia fruit ethanolic extract on MDA level in the blood of Sprague-Dawley induced by 7,12- Dimethylbenz[a]anthracene.
{"title":"EFFECT OF MOMORDICA CHARANTIA FRUIT ETHANOLIC EXTRACT ON MALONDIALDEHYDE (MDA) LEVEL IN BLOOD OF SPRAGUE-DAWLEY RATS INDUCED BY 7,12-DIMETHYLBENZ[A]ANTHRACENE","authors":"Ongky Surya Wijaya Hendro, Eka Yudhanto, A. Himawan, D. Adespin","doi":"10.14710/dmj.v11i1.31226","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.31226","url":null,"abstract":"Background: Cancer is a type of disease with a high rate of diagnostic cases. The real cause of cancer remains unknown. Free radicals can cause cancer by DNA’s gen mutation. 7, 12- Dimethylbenz[a]anthracene (DMBA) is often used for researching carcinogenesis. Many types of research have used natural substances as supportive cancer therapies including Momordica charantia (bitter melon). Malondialdehyde (MDA) is one of the oxidative damage biomarkers which can significantly increase, especially on breast cancer patients. The success of therapy on a breast cancer patient is shown by decreasing MDA levels in the blood. Aim: To investigate the effect of Momordica charantia fruit ethanolic extract on malondialdehyde levels in the blood of Sprague Dawley rats induced by 7,12- Dimethylbenz [a] anthracene. Methods: This study was a true experimental randomized post-test only with control group design on rats that divided into two groups: X1 given DMBA induction only and X2 given DMBA induction with Momordica charantia fruit ethanolic extract by feeding tube with 200mg/kgbw/day for 14 days. Results: The mean of MDA level in group X1 = 0,83±0,32 and in group X2 = 0,30±0,19. The result of the normality test of data using the Shapiro-Wilk test obtained abnormal distribution data for one of the groups. The result of independent-samples T-Test showed a significant difference with P = 0,001. Conclusion: There was an effect of Momordica charantia fruit ethanolic extract on MDA level in the blood of Sprague-Dawley induced by 7,12- Dimethylbenz[a]anthracene.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"177 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120967017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-17DOI: 10.14710/dmj.v11i1.32526
Devy Kurniawati, Dhega Anindita Wibowo, P. Riyanto, W. Widyawati
Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous follicles that is commonly experienced in adolescents and young adults. The pathogenesis of AV is multifactorial, such as caused by inflammation and external factors of acne exposome, which have an impact on the pathogenesis of acne in the use of masks.Objective: To determine the effect of using a mask and the number of acne vulgaris on students of the Faculty of Medicine, Diponegoro University.Methods: This research is an observational type with a cross sectional design. The research subjects were 58 students of the Faculty of Medicine, Diponegoro University with an age range of 19-23 years who used masks. The data obtained are primary data from the questionnaire. The analytical test used is bivariate chi square analysis.Results: This study showed that there was no significant effect between the type of mask and the incidence of acne vulgaris p 0.610 (p>0.05), the duration of the use of masks and the incidence of acne vulgaris p 0.200 (p>0.05), and the frequency of using masks with the incidence of acne vulgaris p 0.689. (p>0.05)Conclusion: There is no effect between the use of masks and the incidence of acne vulgaris.
{"title":"THE EFFECT OF THE USE OF MASK ON THE INCIDENCE OF ACNE VULGARIS IN STUDENTS OF MEDICAL FACULTY DIPONEGORO UNIVERSITY","authors":"Devy Kurniawati, Dhega Anindita Wibowo, P. Riyanto, W. Widyawati","doi":"10.14710/dmj.v11i1.32526","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.32526","url":null,"abstract":"Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous follicles that is commonly experienced in adolescents and young adults. The pathogenesis of AV is multifactorial, such as caused by inflammation and external factors of acne exposome, which have an impact on the pathogenesis of acne in the use of masks.Objective: To determine the effect of using a mask and the number of acne vulgaris on students of the Faculty of Medicine, Diponegoro University.Methods: This research is an observational type with a cross sectional design. The research subjects were 58 students of the Faculty of Medicine, Diponegoro University with an age range of 19-23 years who used masks. The data obtained are primary data from the questionnaire. The analytical test used is bivariate chi square analysis.Results: This study showed that there was no significant effect between the type of mask and the incidence of acne vulgaris p 0.610 (p>0.05), the duration of the use of masks and the incidence of acne vulgaris p 0.200 (p>0.05), and the frequency of using masks with the incidence of acne vulgaris p 0.689. (p>0.05)Conclusion: There is no effect between the use of masks and the incidence of acne vulgaris.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128739949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-17DOI: 10.14710/dmj.v11i1.32294
Ardiansyah Mahardika, D. Armalina, R. D. Purnawati, H. Istiadi, Akhmad Ismail
Abstract Background: Nicotine is a major aspect of smoking. Nicotine cause damage to the lungs because the oxidative stress caused triggers an inflammatory response and lung damage to the alveoli. Garlic extract as an antioxidant agent so that it can against oxidative stress caused by nicotine exposure.Objective: This study is to proving the effect of multilevel dose of garlic extract on lung histopathology of BALB/c mice exposed to nicotine by inhalationMethods: The study used an experimental post test only control group design which was carried out for 24 days. Mice were given an adaptation period of 7 days followed by a treatment period of 14 days. On the last day, the lungs will be terminated and taken for histopathological tests. Mice were divided into 4 groups, namely a Healthy Control Group that was only given standard feed, a Negative Control Group that was given exposure to nicotine by inhalation at a dose of 10 mg/KgBW, treatment group 1 was given garlic extract 300 mg/KgBW orally and exposed to nicotine inhalation with a dose of 10 mg/KgBW, and treatment group 2 who were given garlic extract 500 mg/KgBW orally and exposed to nicotine by inhalation at a dose of 10 mg/KgBW. Histopathological preparations were made on each sample with Hematoxylin-Eosin paint which was then observed microscopically and assessed for severity of damage using scoring criteria.Results: Based on microscopic observations, the degree of lung damage is grouped into normal, mild, moderate, and severe degrees. The results in each group are in the following groups: Healthy Control Group : 73%,27%,0%,0% ; C(-) :0%,0%,33%,67% ; T1 : 0%,33%,67%,0% ; T2 : 0%,100%,0%,0%. The Kruskal Wallis test was performed to obtain significant differences, followed by the Mann Whitnney test which compared the treatment groups which showed significant results.Conclusion: By Giving garlic extract can reduce the degree of microscopic damage of mice lung due to nicotin inhalation exposure.
{"title":"THE EFFECT OF GARLIC (Allium sativum) EXTRACT ON THE HISTOPATOLOGICAL LUNG OF BALB/C MICE WITH NICOTINE EXPOSURE","authors":"Ardiansyah Mahardika, D. Armalina, R. D. Purnawati, H. Istiadi, Akhmad Ismail","doi":"10.14710/dmj.v11i1.32294","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.32294","url":null,"abstract":"Abstract Background: Nicotine is a major aspect of smoking. Nicotine cause damage to the lungs because the oxidative stress caused triggers an inflammatory response and lung damage to the alveoli. Garlic extract as an antioxidant agent so that it can against oxidative stress caused by nicotine exposure.Objective: This study is to proving the effect of multilevel dose of garlic extract on lung histopathology of BALB/c mice exposed to nicotine by inhalationMethods: The study used an experimental post test only control group design which was carried out for 24 days. Mice were given an adaptation period of 7 days followed by a treatment period of 14 days. On the last day, the lungs will be terminated and taken for histopathological tests. Mice were divided into 4 groups, namely a Healthy Control Group that was only given standard feed, a Negative Control Group that was given exposure to nicotine by inhalation at a dose of 10 mg/KgBW, treatment group 1 was given garlic extract 300 mg/KgBW orally and exposed to nicotine inhalation with a dose of 10 mg/KgBW, and treatment group 2 who were given garlic extract 500 mg/KgBW orally and exposed to nicotine by inhalation at a dose of 10 mg/KgBW. Histopathological preparations were made on each sample with Hematoxylin-Eosin paint which was then observed microscopically and assessed for severity of damage using scoring criteria.Results: Based on microscopic observations, the degree of lung damage is grouped into normal, mild, moderate, and severe degrees. The results in each group are in the following groups: Healthy Control Group : 73%,27%,0%,0% ; C(-) :0%,0%,33%,67% ; T1 : 0%,33%,67%,0% ; T2 : 0%,100%,0%,0%. The Kruskal Wallis test was performed to obtain significant differences, followed by the Mann Whitnney test which compared the treatment groups which showed significant results.Conclusion: By Giving garlic extract can reduce the degree of microscopic damage of mice lung due to nicotin inhalation exposure.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133132219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-24DOI: 10.14710/dmj.v11i1.31322
Shabika Shabika, Gustantyo Wahyu Wibowo, R. D. Purnawati, Isniya Nosartika
ABSTRAK Background: Composite resins are able to generate the color of dental restorative materials based on the original teeth's color. Nanofilled composite resins have compressive strength, good polishing, and color stability compared to other types of composite resins. Color changes may occur due to intrinsic and extrinsic factor example mouthwash. Mouthwash that is commonly used is chlorhexidine. The use of chlorhexidine mouthwash continuously may stain the composite resins. Mouthwash that has a good anti-plaque other than chlorhexidine is chlorine dioxide which has a clear color and does not cause changes in taste on the tongue.Aim: To determine the effect of 0.12% chlorhexidine digluconate mouthwash and 0.1% chlorine dioxide mouthwash to the discoloration of nanofilled composite resins. Methods: This study is an experimental study with a pre-test and post-test control group design. Samples are nanofilledcomposite resins made into discs in total of 27 and divided into three groups with different treatments, soaked with 0.12% chlorhexidine digluconate mouthwash, 0.1% chlorine dioxide mouthwash, and sterile distilled water. Each group was soaked for 24 hours and tested for staining using chromameter.Result: ANOVA test showed the significant difference between group, that the greatest color change is the one soaked with 0.12% chlorhexidine digluconate mouthwash compared to 0.1% chlorine dioxide mouthwashConclusions: The use of 0.1% chlorine dioxide mouthwash does not cause discoloration as much as 0.12% chlorhexidine digluconate mouthwash.Keywords: Chlorhexidine digluconate, Chlorine dioxide, nanofilled composite resin, discoloration
{"title":"THE EFFECT OF 0.12% CHLORHEXIDINE DIGLUCONATE AND 0.1% CHLORINE DIOXIDE ON DISCOLORATION OF NANOFILLED COMPOSITE RESIN","authors":"Shabika Shabika, Gustantyo Wahyu Wibowo, R. D. Purnawati, Isniya Nosartika","doi":"10.14710/dmj.v11i1.31322","DOIUrl":"https://doi.org/10.14710/dmj.v11i1.31322","url":null,"abstract":"ABSTRAK Background: Composite resins are able to generate the color of dental restorative materials based on the original teeth's color. Nanofilled composite resins have compressive strength, good polishing, and color stability compared to other types of composite resins. Color changes may occur due to intrinsic and extrinsic factor example mouthwash. Mouthwash that is commonly used is chlorhexidine. The use of chlorhexidine mouthwash continuously may stain the composite resins. Mouthwash that has a good anti-plaque other than chlorhexidine is chlorine dioxide which has a clear color and does not cause changes in taste on the tongue.Aim: To determine the effect of 0.12% chlorhexidine digluconate mouthwash and 0.1% chlorine dioxide mouthwash to the discoloration of nanofilled composite resins. Methods: This study is an experimental study with a pre-test and post-test control group design. Samples are nanofilledcomposite resins made into discs in total of 27 and divided into three groups with different treatments, soaked with 0.12% chlorhexidine digluconate mouthwash, 0.1% chlorine dioxide mouthwash, and sterile distilled water. Each group was soaked for 24 hours and tested for staining using chromameter.Result: ANOVA test showed the significant difference between group, that the greatest color change is the one soaked with 0.12% chlorhexidine digluconate mouthwash compared to 0.1% chlorine dioxide mouthwashConclusions: The use of 0.1% chlorine dioxide mouthwash does not cause discoloration as much as 0.12% chlorhexidine digluconate mouthwash.Keywords: Chlorhexidine digluconate, Chlorine dioxide, nanofilled composite resin, discoloration","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116772842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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