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[Biomechanical approaches in correction of gait in post-stroke hemiparesis]. [生物力学方法在卒中后偏瘫患者步态矫正中的应用]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510203124
V A Gurevich, S V Prokopenko, V S Ondar, N R Kozlov

Neurorehabilitation of post-stroke motor disorders is a relevant and rapidly developing area in modern medicine. Timely correction of the developing pathological gait stereotype is an important task for a physician of physical and rehabilitation medicine. Identification of the central defect in the biomechanics of gait and targeted impact on it using various rehabilitation methods makes it possible to restore the gait function in a patient with post-stroke hemiparesis more effectively.

Objective: To evaluate the effects of rehabilitation using author's technique of shifting the center of gravity of the foot on gait biomechanics in patients with post-stroke hemiparesis.

Material and methods: This article studies a variant of rehabilitation effect on the pathological gait stereotype caused by the violation of the forward outreach of the paretic leg using author's technique of shifting the center of gravity of the foot developed on the basis of the Department of Nervous Diseases of the Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University. A pilot study was carried out with participation of 15 patients undergoing rehabilitation at the 2nd stage in the medical rehabilitation departments No. 2 and 3 of the Federal Siberian Research Clinical Centre under FMBA of Russia (FSRCC FMBA of Russia) in Krasnoyarsk. The patients underwent gait training sessions using technique of shifting the center of gravity of the foot according to the scheme of 10 daily sessions with the duration of 20-40 minutes per day. The function of gait was assessed using the ichnography method.

Results: A comparison of gait function before and after rehabilitation was conducted using the Wilcoxon p-test. The median of the step length of the paretic leg before sessions was 34.31 cm, after sessions 44.84 cm (p<0.01), the median of the step asymmetry, that is, the difference in the step length of the paretic and intact leg, before sessions, was 11.77 cm, after sessions 6.35 cm (p<0.01). Significant improvements in the main spatial parameters of step were obtained against the background of rehabilitation using technique of shifting the center of gravity of the foot.

Conclusion: Training using technique of shifting the center of gravity of the foot improves the function of gait and may be used as a method of motor rehabilitation for patients with post-stroke hemiparesis.

脑卒中后运动障碍的神经康复是现代医学中一个相关且发展迅速的领域。及时纠正正在形成的病理性步态刻板印象是物理康复医学医师的重要任务。识别步态生物力学的中枢缺陷,并利用各种康复方法对其进行针对性的影响,可以更有效地恢复脑卒中后偏瘫患者的步态功能。目的:评价作者提出的足部重心转移康复技术对脑卒中后偏瘫患者步态生物力学的影响。材料和方法:本文利用作者在克拉斯诺亚尔斯克国立医科大学V.F. Voino-Yasenetsky教授神经疾病学系的基础上开发的脚部重心转移技术,研究了对瘫腿前展违反引起的病状步态定型的一种变型康复效果。在克拉斯诺亚尔斯克的俄罗斯联邦西伯利亚研究临床中心(FSRCC俄罗斯联邦西伯利亚研究临床中心)第二和第三医疗康复部门进行了一项试点研究,有15名患者参加了第二阶段的康复。患者采用移动足部重心技术进行步态训练,每日10次,每天20-40分钟。采用平面摄影法评估步态功能。结果:采用Wilcoxon p检验比较康复前后的步态功能。卒中后偏瘫患者步长中位数术前为34.31 cm,术后为44.84 cm。结论:采用足部重心转移技术训练可改善患者的步态功能,可作为卒中后偏瘫患者运动康复的一种方法。
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引用次数: 0
[Possibilities of vibroacoustic therapy application in patients with chronic bronchopulmonary pathology]. [振动声疗法在慢性支气管肺病变患者中的应用可能性]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510201112
A M Schikota, I V Pogonchenkova, E A Turova, I M Rud', M A Rassulova

Chronic bronchopulmonary diseases are a frequent concomitant pathology which potentially affects the clinical and functional status of patients of different profiles undergoing rehabilitation in hospital, that should be taken into account in planning treatment.

Objective: To study the influence of vibroacoustic pulmonary therapy (VAPT) on clinical status and spirometry values of patients undergoing in-patient rehabilitation and with comorbid bronchopulmonary pathology.

Material and methods: We examined 60 patients (18 men (30%) and 42 women (70%)) aged between 18 and 75 years (median age 62 [56; 68] years) with chronic lung diseases (chronic bronchitis, chronic obstructive pulmonary disease), undergoing an in-patient rehabilitation for disorders of the central nervous and musculoskeletal systems. The study group consisted of 30 patients who had a 5-day course of VAPT in the individual medical rehabilitation program; the control group included 30 patients who did not underwent VAPT. Qualitative and quantitative characteristics of respiratory symptoms and parameters of spirometry before and after VAPT course were studied.

Results: In this study 37 (62%) of subjects underwent rehabilitation regarding pathology of the central nervous system, 23 (38%) - regarding musculoskeletal pathology, 40 (67%) had concomitant cardiovascular diseases among all patients. Complaints of dyspnea were presented by 96.7% of patients in the study group and 90% of patients in the control group, mean value of dyspnea intensity on the mMRC scale amounted to 2.1±0.89 and 2.1±0.8 scores, respectively. Cough occurred in 83% of patients in the study group and 80% of patients in the control group, mean value on the 6-score daily and night cough scale was 2.0±1.3 and 1.9±0.84 scores, respectively. There has been a decrease in the number of patients with dyspnea and cough to 83.3 and 66.7%, respectively, a decrease in the dyspnea degree on the mMRC scale by 19% (p<0.05) and the cough severity by 22.3% (p≤0.001) in the study group after VAPT. An increase of the peak expiratory flow rate by 5% (p≤0.05) has been revealed according to spirometry data. No significant improvement of the studied indicators has been achieved in the control group of patients. No serious cardiovascular adverse events and complications have been registered during rehabilitation, the results of the patients' questionnaire survey characterize the method positively.

Conclusion: The performed study's results, that showed a regression of respiratory symptoms and improvement of pulmonary function during the in-patient rehabilitation of subjects with comorbid chronic bronchopulmonary pathology, allow to consider VAPT as a promising non-drug treatment method in this category of patients.

慢性支气管肺疾病是一种常见的并发病症,可能会影响在医院接受康复治疗的不同类型患者的临床和功能状态,在制定治疗计划时应考虑到这一点:研究振动声肺疗法(VAPT)对接受住院康复治疗且合并支气管肺部病变的患者的临床状态和肺活量值的影响:我们研究了 60 名因中枢神经和肌肉骨骼系统疾病而接受住院康复治疗的慢性肺部疾病(慢性支气管炎、慢性阻塞性肺病)患者(18 名男性(30%)和 42 名女性(70%)),他们的年龄在 18 岁至 75 岁之间(中位年龄为 62 [56; 68] 岁)。研究组包括 30 名在个人医疗康复计划中接受了为期 5 天的 VAPT 治疗的患者;对照组包括 30 名未接受 VAPT 治疗的患者。研究了 VAPT 课程前后呼吸系统症状的定性和定量特征以及肺活量测定的参数:在这项研究中,37 名受试者(62%)接受了中枢神经系统疾病康复治疗,23 名受试者(38%)接受了肌肉骨骼疾病康复治疗,40 名受试者(67%)同时患有心血管疾病。研究组和对照组分别有 96.7% 和 90% 的患者出现呼吸困难症状,在 mMRC 量表中,呼吸困难强度的平均值分别为 2.1±0.89 分和 2.1±0.8 分。研究组 83% 的患者和对照组 80% 的患者出现咳嗽,日咳和夜咳 6 分量表的平均值分别为(2.0±1.3)分和(1.9±0.84)分。VAPT后,研究组呼吸困难和咳嗽患者人数分别减少至83.3%和66.7%,mMRC量表中的呼吸困难程度降低了19%(pp≤0.001)。肺活量数据显示,呼气峰流速增加了 5%(p≤0.05)。对照组患者的研究指标没有明显改善。康复期间未出现严重的心血管不良事件和并发症,患者问卷调查结果对该方法给予了肯定:研究结果表明,在对合并慢性支气管肺病的患者进行住院康复治疗期间,呼吸道症状有所缓解,肺功能有所改善,因此可以认为 VAPT 是一种对这类患者很有前途的非药物治疗方法。
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引用次数: 0
[Promising models of sanatorium-resort provision organization in the Armed Forces of the Russian Federation]. [俄罗斯联邦武装部队提供疗养胜地组织的有前途的模式]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort20251020115
A A Kirsanova, A F Sukhoterin, S V Dolgikh, D V Kovlen

The article discusses the need for development of a modern system of sanatorium-resort treatment and medical rehabilitation in the Armed Forces of the Russian Federation. It is proposed to consider different models of sanatorium-resort provision organization in order to accommodate the requirements of different categories of military personnel and their families. This concept will contribute to the improvement of efficiency and quality of provided services. Development of infrastructure, implementation of modern technologies, improvement of staff qualification and creation of conditions for recreation and treatment are the key aspects of successful organization of sanatorium-resort provision.

文章讨论了在俄罗斯联邦武装部队中发展疗养疗养和医疗康复的现代制度的必要性。建议考虑采用不同的疗养胜地提供组织模式,以适应不同类别的军事人员及其家属的需要。这一概念将有助于提高所提供服务的效率和质量。发展基础设施、采用现代技术、提高工作人员的资格和创造娱乐和治疗的条件是成功组织疗养胜地的关键方面。
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引用次数: 0
[Stabilometry as a tool for assessing postural balance: modern approaches, methods, and standardization issues. (Literature review)]. 稳定性测量法作为评估姿势平衡的工具:现代方法、方法和标准化问题。(文献综述)。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510204156
E A Mayorov, M R Makarova, D A Somov, E V Kostenko, I V Pogonchenkova

Postural balance impairment is associated with an increased risk of falls, reduced daily activity, and a decline in patients' quality of life. Given that balance function is one of the fundamental and most vital functions for life, the objective diagnosis and correction of its pathology remain highly relevant in clinical practice.

Objective: To examine modern approaches to the methodology and specific techniques used in stabilometric assessment of postural balance and to analyze the current state of standardization of stabilometry in both clinical practice and scientific research.

Material and methods: The review includes studies of varying levels of evidence (randomized controlled trials, systematic reviews, cohort studies, non-systematic reviews, consensus documents) identified through databases such as PubMed, Mendeley, ScienceDirect, eLIBRARY.RU, Google Scholar, and CyberLeninka covering the period from 2000 to 2025. Modern approaches to assessing postural balance are discussed, along with the main reasons for the absence of unified standardized reference values in stabilometric studies.

Results: Stabilometry - a method of quantitatively evaluating postural balance by analyzing oscillations of the center of pressure projection on a support surface - is considered a modern tool for diagnosing postural imbalance. However, the diversity of protocols used in stabilometric testing, the lack of uniform standards for data processing and interpretation, and the need to account for variable individual patient parameters limit the application of this method in clinical settings and reduce the informativeness and comparability of scientific studies.

Conclusion: To enhance the validity and reliability of stabilometric research, standardization in technical, software, and terminological domains (development of protocols and data processing standards) is required to fully realize the potential of this method.

体位平衡障碍与跌倒风险增加、日常活动减少和患者生活质量下降有关。鉴于平衡功能是生命最基本和最重要的功能之一,其病理的客观诊断和纠正在临床实践中仍然具有重要意义。目的:探讨体位平衡稳定性评估的方法和具体技术的现代方法,分析临床和科学研究中稳定测量标准化的现状。材料和方法:本综述包括通过PubMed、Mendeley、ScienceDirect、eLIBRARY等数据库确定的不同证据水平的研究(随机对照试验、系统评价、队列研究、非系统评价、共识文件)。RU, b谷歌学者,和网络列宁卡涵盖2000年至2025年。讨论了评估姿势平衡的现代方法,以及在稳定性研究中缺乏统一的标准化参考值的主要原因。结果:稳定性测量法是一种通过分析压力投影中心在支撑表面上的振荡来定量评估体位平衡的方法,被认为是诊断体位失衡的现代工具。然而,稳定性测试中使用的方案的多样性,缺乏统一的数据处理和解释标准,以及需要考虑可变的个体患者参数,限制了该方法在临床环境中的应用,降低了科学研究的信息性和可比性。结论:为了提高稳定性计量研究的有效性和可靠性,需要在技术、软件和术语领域进行标准化(制定协议和数据处理标准),以充分发挥该方法的潜力。
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引用次数: 0
[Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes]. [椎体源性肌肉紧张性神经根综合征患者的康复]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510206113
E V Panteleev, S V Matveev, K E Moiseeva

Backgraund: Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes allows not only to get rid of pain, but also to return a person's ability to move, restore working capacity and significantly improve the quality of life, minimizing the risk of future exacerbations.

Aims: Development of scientifically based approaches to comprehensive rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes aimed at restoring lost functions, reducing pain syndrome and returning patients with DDZP to active everyday life.

Material and methods: A total of 89 patients with vertebrogenic muscular-tonic and radicular syndromes with dorsopathy were examined. The average age and duration of the disease in patients were 52.1±7.34 years and 5.0±1.12 years, respectively. The dynamics of the clinical and objective state of patients with DDZP was assessed using various treatment regimens. Statistical processing of the study results was carried out using the Statistica 10.0 software package. Differences were considered significant at p<0.05.

Results: The results of the study demonstrate a significant improvement in the clinical and objective condition of patients with DDD when using various treatment regimens, especially when using therapy according to regimens III and IV. Evaluation of the dynamics of complaints showed that treatment according to these regimens is more effective than according to regimen I. Objective indicators, which include radiographic signs of scoliosis and MRI data, also indicate positive dynamics when using therapy regimens III and IV. In most patients who received therapy according to these regimens, signs of disc deformation disappeared. The identified improvements in ENMG signs during therapy according to III and IV regimens show a decrease in radicular and neuromuscular disorders.

Conclusions: In the rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes, the most effective treatment method is courses of manual therapy and acupuncture.

背景:椎体源性肌肉紧张性和神经根综合征患者的康复治疗不仅可以消除疼痛,还可以恢复患者的活动能力,恢复工作能力,显著提高生活质量,最大限度地降低未来病情恶化的风险。目的:发展基于科学的方法对椎体源性肌肉紧张性和神经根综合征患者进行综合康复,旨在恢复丧失的功能,减轻疼痛综合征,使DDZP患者恢复活跃的日常生活。材料和方法:对89例椎体源性肌肉紧张性和神经根性综合征合并腰背病患者进行检查。患者的平均年龄为52.1±7.34岁,病程为5.0±1.12岁。采用不同的治疗方案对DDZP患者的临床和客观状态进行动态评估。采用Statistica 10.0软件包对研究结果进行统计处理。差异在结果中被认为是显著的:研究结果表明,采用各种治疗方案,特别是采用方案III和方案IV, DDD患者的临床和客观状况均有显著改善。对投诉动态的评估表明,采用这些方案的治疗比采用方案i的治疗更有效。在使用治疗方案III和IV时也显示出积极的动力。在大多数接受这些方案治疗的患者中,椎间盘变形的迹象消失了。根据III和IV方案治疗期间ENMG体征的改善表明神经根和神经肌肉疾病的减少。结论:在椎体源性肌肉紧张性神经根综合征患者的康复治疗中,最有效的治疗方法是推拿加针灸治疗。
{"title":"[Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes].","authors":"E V Panteleev, S V Matveev, K E Moiseeva","doi":"10.17116/kurort202510206113","DOIUrl":"https://doi.org/10.17116/kurort202510206113","url":null,"abstract":"<p><strong>Backgraund: </strong>Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes allows not only to get rid of pain, but also to return a person's ability to move, restore working capacity and significantly improve the quality of life, minimizing the risk of future exacerbations.</p><p><strong>Aims: </strong>Development of scientifically based approaches to comprehensive rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes aimed at restoring lost functions, reducing pain syndrome and returning patients with DDZP to active everyday life.</p><p><strong>Material and methods: </strong>A total of 89 patients with vertebrogenic muscular-tonic and radicular syndromes with dorsopathy were examined. The average age and duration of the disease in patients were 52.1±7.34 years and 5.0±1.12 years, respectively. The dynamics of the clinical and objective state of patients with DDZP was assessed using various treatment regimens. Statistical processing of the study results was carried out using the Statistica 10.0 software package. Differences were considered significant at <i>p</i><0.05.</p><p><strong>Results: </strong>The results of the study demonstrate a significant improvement in the clinical and objective condition of patients with DDD when using various treatment regimens, especially when using therapy according to regimens III and IV. Evaluation of the dynamics of complaints showed that treatment according to these regimens is more effective than according to regimen I. Objective indicators, which include radiographic signs of scoliosis and MRI data, also indicate positive dynamics when using therapy regimens III and IV. In most patients who received therapy according to these regimens, signs of disc deformation disappeared. The identified improvements in ENMG signs during therapy according to III and IV regimens show a decrease in radicular and neuromuscular disorders.</p><p><strong>Conclusions: </strong>In the rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes, the most effective treatment method is courses of manual therapy and acupuncture.</p>","PeriodicalId":39492,"journal":{"name":"Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury","volume":"102 6","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Rehabilitation of patients with post-COVID syndrome depending on C(159)T polymorphism of SD-14 gene]. [SD-14基因C(159)T多态性对covid - 19后综合征患者康复的影响]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510201142
L Sh Dudchenko, V A Beloglazov, S N Belyaeva, I A Yatskov, E A Solovyova, G N Andreeva, I V Shulyak
<p><p>Researchers are interested in studying the genes that regulate immunocompetent molecules. Genetic polymorphism has an impact on morbidity, mortality and the reserves of the body's recovery in communicable diseases.</p><p><strong>Objective: </strong>To study the possibilities of rehabilitation of patients with post-COVID syndrome (PCS) in the conditions of a sanatorium-resort organization depending on the genetic polymorphism of the <i>CD-14</i> monocytes receptor gene.</p><p><strong>Material and methods: </strong>The study included 97 patients with COVID-19 past history and PCS diagnosis, who underwent rehabilitation in the Department of Pulmonology of the I.M. Sechenov Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation (Yalta). Comprehensive clinical, laboratory and functional examinations of patients were performed. Questionnaires for assessment of dyspnea, psychological state and quality of life were additionally used. Determination of genotype variants was done using sets of the «Lytech» company (Russia) according to the manufacturer's instructions. The detection of amplification products for C(159)T polymorphism of the <i>SD-14</i> gene was performed by means of horizontal electrophoresis in 3% agarose gel. Patients received comprehensive rehabilitation including: climatotherapy, physical therapy, massage, aromatherapy, respiratory therapy and pharmaceutical treatments as medically indicated. The treatment course was 21 days. Evaluation of the efficacy of therapy was carried out on the basis of studying the dynamics of the investigational indicators before and after the rehabilitation course.</p><p><strong>Results: </strong>Patients were divided into 3 groups according to the data of performed analysis: with variants of homozygous distribution of CC alleles - 30 (30.9%) patients and TT - 22 (22.7%) patients, as well as with heterozygous variant of CT - 45 (46.4%) patients. It has been established that the most pronounced respiratory symptoms, degree of dyspnea, low grade by questionnaires of dyspnea, low value of the indicators of pulmonary function tests, laboratory abnormalities, as well as more significant reduction of life quality, development of anxiety, low assessment of the level of one's own health are characteristic for CC genotype. Patients with this genotype's variant were more likely to have obesity and dyslipidemia, which exacerbated respiratory symptoms. The heterozygous CT variant of genotype, in which more indicators had a significant positive dynamics during rehabilitation, proved to be more sensitive to rehabilitative exposure.</p><p><strong>Conclusion: </strong>The state of PCS depending on the genotypes of the <i>SD-14</i> gene was studied. The most pronounced symptoms were revealed in CC159 genotype. The best dynamics during the rehabilitation period in the sanatorium-resort organization has been noted in the heterozygous variant of CT159 genotype of the <i>SD-14</i> gene, s
研究人员对研究调节免疫活性分子的基因很感兴趣。遗传多态性对传染病的发病率、死亡率和机体恢复储备有影响。目的:研究CD-14单核细胞受体基因多态性对疗养疗养机构条件下新冠肺炎后综合征(PCS)患者康复的影响。材料和方法:本研究纳入97例既往病史和PCS诊断为COVID-19的患者,这些患者在imm Sechenov物理治疗方法、医学气候学和康复研究所(雅尔塔)肺内科接受康复治疗。对患者进行全面的临床、实验室和功能检查。此外,还使用问卷评估呼吸困难、心理状态和生活质量。根据制造商的说明,使用“Lytech”公司(俄罗斯)的试剂盒进行基因型变异的测定。采用3%琼脂糖凝胶水平电泳检测SD-14基因C(159)T多态性扩增产物。患者接受了全面的康复治疗,包括:气候疗法、物理疗法、按摩、芳香疗法、呼吸疗法和医学指示的药物治疗。疗程21 d。在研究康复疗程前后各项研究指标动态的基础上,对治疗效果进行评价。结果:根据已完成的分析资料将患者分为3组:CC等位基因纯合分布变异- 30(30.9%)患者和TT - 22(22.7%)患者以及CT - 45杂合变异(46.4%)患者。已经确定,最明显的呼吸症状,呼吸困难程度,呼吸困难问卷评分低,肺功能检查指标值低,实验室异常,以及更明显的生活质量下降,焦虑的发展,对自身健康水平的低评估是CC基因型的特征。携带这种基因型变异的患者更容易出现肥胖和血脂异常,从而加重呼吸道症状。基因型的杂合型CT变异对康复暴露更敏感,其中更多的指标在康复过程中具有显著的正动态。结论:研究了SD-14基因型对PCS状态的影响。CC159基因型的症状最为明显。SD-14基因CT159基因型的杂合变异在疗养疗养机构康复期间的动态最好,在CC基因型组中略有降低,在TT组中并非所有指标的动态都很显著。PCS患者基因型检测有助于个性化康复方案,提高康复方案对新冠肺炎患者身心状态全面恢复的疗效。
{"title":"[Rehabilitation of patients with post-COVID syndrome depending on C(159)T polymorphism of SD-14 gene].","authors":"L Sh Dudchenko, V A Beloglazov, S N Belyaeva, I A Yatskov, E A Solovyova, G N Andreeva, I V Shulyak","doi":"10.17116/kurort202510201142","DOIUrl":"10.17116/kurort202510201142","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Researchers are interested in studying the genes that regulate immunocompetent molecules. Genetic polymorphism has an impact on morbidity, mortality and the reserves of the body's recovery in communicable diseases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To study the possibilities of rehabilitation of patients with post-COVID syndrome (PCS) in the conditions of a sanatorium-resort organization depending on the genetic polymorphism of the &lt;i&gt;CD-14&lt;/i&gt; monocytes receptor gene.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;The study included 97 patients with COVID-19 past history and PCS diagnosis, who underwent rehabilitation in the Department of Pulmonology of the I.M. Sechenov Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation (Yalta). Comprehensive clinical, laboratory and functional examinations of patients were performed. Questionnaires for assessment of dyspnea, psychological state and quality of life were additionally used. Determination of genotype variants was done using sets of the «Lytech» company (Russia) according to the manufacturer's instructions. The detection of amplification products for C(159)T polymorphism of the &lt;i&gt;SD-14&lt;/i&gt; gene was performed by means of horizontal electrophoresis in 3% agarose gel. Patients received comprehensive rehabilitation including: climatotherapy, physical therapy, massage, aromatherapy, respiratory therapy and pharmaceutical treatments as medically indicated. The treatment course was 21 days. Evaluation of the efficacy of therapy was carried out on the basis of studying the dynamics of the investigational indicators before and after the rehabilitation course.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Patients were divided into 3 groups according to the data of performed analysis: with variants of homozygous distribution of CC alleles - 30 (30.9%) patients and TT - 22 (22.7%) patients, as well as with heterozygous variant of CT - 45 (46.4%) patients. It has been established that the most pronounced respiratory symptoms, degree of dyspnea, low grade by questionnaires of dyspnea, low value of the indicators of pulmonary function tests, laboratory abnormalities, as well as more significant reduction of life quality, development of anxiety, low assessment of the level of one's own health are characteristic for CC genotype. Patients with this genotype's variant were more likely to have obesity and dyslipidemia, which exacerbated respiratory symptoms. The heterozygous CT variant of genotype, in which more indicators had a significant positive dynamics during rehabilitation, proved to be more sensitive to rehabilitative exposure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The state of PCS depending on the genotypes of the &lt;i&gt;SD-14&lt;/i&gt; gene was studied. The most pronounced symptoms were revealed in CC159 genotype. The best dynamics during the rehabilitation period in the sanatorium-resort organization has been noted in the heterozygous variant of CT159 genotype of the &lt;i&gt;SD-14&lt;/i&gt; gene, s","PeriodicalId":39492,"journal":{"name":"Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury","volume":"102 1","pages":"42-50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prediction of restoration of functional activity of paretic limbs in patients who have suffered an ischemic stroke]. [缺血性中风患者肢体麻痹功能活动恢复的预测]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510203131
N F Miryutova, V A Fokin, N N Minchenko, S V Alaytseva

The World Stroke Organization notes the growing number of strokes worldwide. Motor disorders in the paretic limbs are one of the most common consequences of stroke, which significantly affects the quality of patients' daily lives. The possibility of early prediction of clinical and functional recovery of patients after stroke is an important component of the rehabilitation process.

Objective: To develop a model for predicting the restoration of the functional activity of paretic limbs and mobility of patients in the early recovery period of ischemic stroke and to evaluate the results of rehabilitation with a positive and negative prognosis.

Material and methods: The prognostic factors used were the results of an assessment of motor disorders, balance function on the Fugl-Meyer scale and interhemispheric brain activity (Brain symmetry indices in standard electroencephalogram leads), as well as the patient's age, prescription of stroke, and level of vital activity at the time of examination. The functional activity of paretic limbs and mobility of patients were assessed using validated scales (Action Research Arm Test, Modified Frenchay scale, Wolf Motor Function Test, Rivermead mobility index, Hauser ambulance index, Functional Independence Measurement). The TIBCO Software Inc. (2017) program was used to build the model, Statistica, version 13. The Mann-Whitney criterion was used to identify differences between subgroups.

Results: A new method for predicting the functional recovery of paretic limb activity after ischemic stroke has been developed (patent RU2825714C1, publ. 08/28/2024). The forecast model developed by the logistic regression method is statistically significant (χ2=43.26; p<0.001. Operational characteristics of the test (training sample of 91 patients): sensitivity - 84%, specificity - 83%, diagnostic accuracy - 84%. After rehabilitation, a statistically significantly greater increase in the indicators of functional activity of paretic limbs and mobility was revealed in patients with a positive prognosis compared with a subgroup of patients with a negative prognosis.

Conclusions: The obtained model makes it possible to predict the recovery of patients' activity in terms of self-care and movement in the first six months after an ischemic stroke in the presence of limb paresis.

世界中风组织注意到世界范围内中风人数的增长。肢体麻痹的运动障碍是卒中最常见的后果之一,严重影响患者的日常生活质量。早期预测脑卒中患者的临床和功能恢复的可能性是康复过程的重要组成部分。目的:建立预测缺血性脑卒中恢复期患者四肢功能活动和活动能力恢复的模型,并对预后好坏的康复效果进行评价。材料和方法:使用的预后因素是运动障碍、Fugl-Meyer量表平衡功能和脑半球间活动(标准脑电图导联中的脑对称指数)的评估结果,以及患者的年龄、卒中处方和检查时的生命活动水平。采用经验证的量表(动作研究臂测试、改良Frenchay量表、Wolf运动功能测试、Rivermead运动能力指数、Hauser救护车指数、功能独立性测量)评估患者的四肢功能活动和活动能力。使用TIBCO软件公司(2017)程序构建模型,Statistica,版本13。曼-惠特尼标准用于确定亚组之间的差异。结果:开发了一种预测缺血性脑卒中后肢体活动功能恢复的新方法(专利号RU2825714C1,公开号)。08/28/2024)。logistic回归方法建立的预测模型有统计学意义(χ2=43.26;结论:所建立的模型可以预测出现肢体麻痹的缺血性脑卒中患者在术后6个月内的自理能力和运动能力的恢复情况。
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引用次数: 0
[Study of the dynamics of arterial pressure and body composition during manual physical therapy using the method of A.Yu. Shishonin]. [A.Yu方法在手工物理治疗中动脉压和身体成分的动态研究。]Shishonin]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510203141
A Yu Shishonin, V I Pavlov

The most striking and widespread representatives of chronic non-infectious diseases are essential arterial hypertension (EAH) and type 2 diabetes mellitus. Recently, in the pathogenesis of the above-mentioned nosologies, theories have become widespread associated with a violation of the regulation of these processes by the central nervous system, which are a consequence of hypoxia of the reflex regulatory centers of the brain. One of the most promising methods for eliminating hypoxia of brain structures is the method of manual-physical influence (therapy) according to the method of A.Yu. Shishonin.

Objective: To study the effect of manual physical therapy on blood pressure (BP) and body composition in patients with EAH.

Material and methods: The study included 144 patients (mean age 59.9±3.7 years) with EAH or high normal BP (prehypertension), divided into 2 groups. The main group included 110 patients (47 men and 63 women), whose BP was measured according to Korotkov and heart rate was recorded, and body composition was also studied at least three times - before the start of therapy, in the middle of the session and immediately after its completion. The control group included 34 patients (17 men and 17 women), who refused both recommended and alternative treatment methods for various reasons, who were measured at the same time as the main group.

Body composition was studied using bioimpedancemetry.

Results: During therapy using the method of A.Yu. Shishonin, the study group showed a significant decrease in SBP by the middle of the course by 11.3 mm Hg, and after completion - by 22.3 mm Hg. DBP significantly decreased after the middle of the course by 3.4 mm Hg, and by the end of therapy - by 4.4 mm Hg. HR by the end of manual-physical correction sessions significantly decreased by 12 beats/min. The fat mass in the study group by the end of therapy significantly decreased by 3.5 kg, the loss of total fluid by the end of the course was significantly 8.3 kg. An increase in muscle mass was recorded, which did not reach the level of reliability. In patients of the control group, changes in bioimpedance parameters were of a multidirectional nature and did not reach the level of reliability.

Conclusion: The method of manual-physical correction according to A.Yu. Shishonin is an effective method for reducing blood pressure and normalizing body composition. Its effect is probably mediated by improved blood supply to regulatory structures, normalization of eating behavior and sympathoadrenal activity within the framework of the «selfish brain» theory.

慢性非传染性疾病最显著和最广泛的代表是原发性动脉高血压(EAH)和2型糖尿病。最近,在上述疾病的发病机制中,与中枢神经系统对这些过程的调节受到破坏有关的理论越来越普遍,这是大脑反射调节中心缺氧的结果。消除脑结构缺氧最有前途的方法之一是人工-物理影响(治疗)的方法,根据A.Yu的方法。Shishonin。目的:探讨手工物理治疗对EAH患者血压及体成分的影响。材料与方法:144例EAH或血压正常偏高(高血压前期)患者(平均年龄59.9±3.7岁)分为两组。主要组包括110名患者(47名男性和63名女性),他们的血压根据Korotkov测量并记录心率,身体成分也被研究了至少三次——治疗开始前、治疗中期和治疗结束后。对照组34例患者(男17例,女17例),因各种原因拒绝推荐治疗方法和替代治疗方法,与主要组同时测量。用生物阻抗法研究体成分。结果:在治疗过程中,采用A.Yu法。Shishonin,研究组的收缩压在疗程中期显著降低了11.3 mm Hg,完成后显著降低了22.3 mm Hg。舒张压在疗程中期显著降低了3.4 mm Hg,治疗结束时显著降低了4.4 mm Hg。HR在手动-物理矫正疗程结束时显著降低了12次/分。治疗结束时,研究组脂肪量显著减少3.5 kg,总液体损失显著8.3 kg。肌肉质量的增加被记录下来,但没有达到可靠的水平。在对照组患者中,生物阻抗参数的变化是多向的,没有达到可靠的水平。结论:采用人工-物理矫正法。水蛭素是降低血压和使身体成分正常化的有效方法。在“自私大脑”理论的框架内,它的作用可能是通过改善调节结构的血液供应、饮食行为的正常化和交感肾上腺活动来调节的。
{"title":"[Study of the dynamics of arterial pressure and body composition during manual physical therapy using the method of A.Yu. Shishonin].","authors":"A Yu Shishonin, V I Pavlov","doi":"10.17116/kurort202510203141","DOIUrl":"https://doi.org/10.17116/kurort202510203141","url":null,"abstract":"<p><p>The most striking and widespread representatives of chronic non-infectious diseases are essential arterial hypertension (EAH) and type 2 diabetes mellitus. Recently, in the pathogenesis of the above-mentioned nosologies, theories have become widespread associated with a violation of the regulation of these processes by the central nervous system, which are a consequence of hypoxia of the reflex regulatory centers of the brain. One of the most promising methods for eliminating hypoxia of brain structures is the method of manual-physical influence (therapy) according to the method of A.Yu. Shishonin.</p><p><strong>Objective: </strong>To study the effect of manual physical therapy on blood pressure (BP) and body composition in patients with EAH.</p><p><strong>Material and methods: </strong>The study included 144 patients (mean age 59.9±3.7 years) with EAH or high normal BP (prehypertension), divided into 2 groups. The main group included 110 patients (47 men and 63 women), whose BP was measured according to Korotkov and heart rate was recorded, and body composition was also studied at least three times - before the start of therapy, in the middle of the session and immediately after its completion. The control group included 34 patients (17 men and 17 women), who refused both recommended and alternative treatment methods for various reasons, who were measured at the same time as the main group.</p><p><p>Body composition was studied using bioimpedancemetry.</p><p><strong>Results: </strong>During therapy using the method of A.Yu. Shishonin, the study group showed a significant decrease in SBP by the middle of the course by 11.3 mm Hg, and after completion - by 22.3 mm Hg. DBP significantly decreased after the middle of the course by 3.4 mm Hg, and by the end of therapy - by 4.4 mm Hg. HR by the end of manual-physical correction sessions significantly decreased by 12 beats/min. The fat mass in the study group by the end of therapy significantly decreased by 3.5 kg, the loss of total fluid by the end of the course was significantly 8.3 kg. An increase in muscle mass was recorded, which did not reach the level of reliability. In patients of the control group, changes in bioimpedance parameters were of a multidirectional nature and did not reach the level of reliability.</p><p><strong>Conclusion: </strong>The method of manual-physical correction according to A.Yu. Shishonin is an effective method for reducing blood pressure and normalizing body composition. Its effect is probably mediated by improved blood supply to regulatory structures, normalization of eating behavior and sympathoadrenal activity within the framework of the «selfish brain» theory.</p>","PeriodicalId":39492,"journal":{"name":"Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury","volume":"102 3","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The use of traction therapy in patients with spinal deformities at the stage of using functional corrective corsets]. [牵引治疗在脊柱畸形患者使用功能性矫正胸衣阶段的应用]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort202510206119
S V Vasilevich, I A Komolkin

Introduction: Conservative treatment of patients with scoliosis and kyphoscoliotic spinal deformities is the most affordable and safe method of treatment. Non-surgical treatment of such patients takes a long period of time and includes the complex use of various factors, including physiotherapy, therapeutic gymnastics, swimming, massage, manual therapy, and the use of various types of functional corrective corsets. They are used on a regular basis until the bone growth zones are closed and/or deformity is sufficiently corrected.

The result of using corsets depends on many factors and is not always positive. One of the factors that reduce the effectiveness of this method is the poor tolerance (or intolerance) of these corsets due to pain sensations that occur at the sites of corrective efforts, as well as limited mobility of the spine.

Various methods are used to increase the mobility of the spine (physical therapy with stretching elements, massage, manual therapy).

Traction therapy (stretching of the spine) can be attributed to methods that increase the mobility of the spine. Reports on the effectiveness of isolated traction therapy in patients with various static deformities are contradictory.

Objective: To evaluate the prospects of using traction therapy in patients with significant static spinal deformities using a functionally corrective corset to facilitate the period of adaptation to regular wearing of a functionally corrective corset, and to reduce pain and discomfort from pressure exerted by the pressure zones of the corset; to increase spinal mobility.

Material and methods: The publication describes the experience of using traction therapy in 52 adolescent patients undergoing inpatient conservative treatment for severe static spinal deformities at the stage of using a functional corrective corset.

Results and discussion: As a result of the work, the following conclusions can be drawn: the use of traction therapy significantly reduces pain and discomfort associated with the use of a functionally corrective corset. There were no negative reactions or complications from the use of traction therapy.

Conclusion: Traction therapy should be used in the complex conservative treatment of patients with scoliosis and kyphoscoliosis as an additional method at the stage of using functionally corrective corsets, including difficulties in adapting to corset treatment. Traction therapy can also be used to prepare a patient for an orthosis.

简介:保守治疗脊柱侧凸和脊柱后凸性畸形是最经济、最安全的治疗方法。这类患者的非手术治疗需要很长时间,包括多种因素的综合运用,包括物理治疗、治疗性体操、游泳、按摩、手工治疗,以及使用各种类型的功能性矫正胸衣。他们定期使用,直到骨生长区域关闭和/或畸形得到充分纠正。使用紧身胸衣的结果取决于许多因素,并不总是积极的。降低这种方法有效性的因素之一是由于矫正部位的疼痛感以及脊柱的活动受限,这些紧身胸衣的耐受性差(或不耐受)。使用各种方法来增加脊柱的活动性(物理疗法与拉伸元素,按摩,手工疗法)。牵引疗法(拉伸脊柱)可归因于增加脊柱活动性的方法。关于孤立牵引治疗各种静态畸形的有效性的报道是相互矛盾的。目的:评价牵引疗法在使用功能性矫正胸衣的明显脊柱静态畸形患者中应用的前景,以促进对常规穿着功能性矫正胸衣的适应期,并减轻胸衣压力区施加的压力带来的疼痛和不适;增加脊柱的活动性。材料和方法:该出版物描述了52例在使用功能性矫正胸衣阶段接受严重静态脊柱畸形住院保守治疗的青少年患者使用牵引治疗的经验。结果和讨论:通过这项工作,我们可以得出以下结论:牵引疗法的使用显著减少了与使用功能性矫正胸衣相关的疼痛和不适。使用牵引治疗无不良反应或并发症。结论:在使用功能矫正胸衣阶段,包括适应胸衣治疗困难的情况下,在脊柱侧凸及后凸性脊柱侧凸患者的复杂保守治疗中,应采用牵引治疗作为一种附加方法。牵引疗法也可以用来为矫形器做准备。
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引用次数: 0
[Biomarkers of aging mechanisms]. [衰老机制的生物标志物]。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.17116/kurort2025102052108
T O Amirova, A A Moskalev

Objective: To systematize current knowledge on biomarkers of fundamental aging mechanisms, their reference and target values for practical application in longevity medicine.

Material and methods: Analysis of scientific literature on 14 key aging mechanisms according to the modern gerontological concept, including genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, microbiome dysbiosis, extracellular matrix stiffness and barrier dysfunction, as well as circadian rhythm disruption.

Results: A comprehensive system of 30+biomarkers with detailed reference and target values is presented. Key biomarkers include: urinary 8-OHdG (target values<5.0 ng/mg creatinine), leukocyte telomere length (target >6000 base pairs), N7-methylguanine (<6-7 μg/g creatinine), dityrosine (≤10-12 μmol/mol creatinine), p62 and Beclin-1 for autophagy assessment, HOMA-IR (<1.5), IGF-1 (100-150 ng/ml), mitochondrial markers, senescence-associated β-galactosidase (<3% positive cells), inflammatory cytokines, microbiome-associated markers, and circadian biomarkers.

Conclusion: The developed biomarker panel provides a scientifically grounded foundation for personalized assessment of aging rate and correction of age-associated changes, requiring regular monitoring every 3-6 months for effective interpretation of biomarker dynamics.

目的:梳理目前有关衰老基本机制的生物标志物及其在长寿医学实际应用中的参考价值和目标值。材料和方法:根据现代老年学概念分析14种关键衰老机制的科学文献,包括基因组不稳定、端粒缩短、表观遗传改变、蛋白质稳态丧失、巨噬受损、营养感知失调、线粒体功能障碍、细胞衰老、干细胞耗竭、细胞间通讯改变、慢性炎症、微生物群失调、细胞外基质僵硬和屏障功能障碍。以及昼夜节律紊乱。结果:建立了一个包含30多种生物标志物的综合体系,具有详细的参考值和目标值。关键生物标志物包括:尿8-OHdG(目标值6000个碱基对),n7 -甲基鸟嘌呤(结论:开发的生物标志物面板为个性化评估衰老速度和纠正年龄相关变化提供了科学依据,需要每3-6个月定期监测,以有效解释生物标志物动态。
{"title":"[Biomarkers of aging mechanisms].","authors":"T O Amirova, A A Moskalev","doi":"10.17116/kurort2025102052108","DOIUrl":"https://doi.org/10.17116/kurort2025102052108","url":null,"abstract":"<p><strong>Objective: </strong>To systematize current knowledge on biomarkers of fundamental aging mechanisms, their reference and target values for practical application in longevity medicine.</p><p><strong>Material and methods: </strong>Analysis of scientific literature on 14 key aging mechanisms according to the modern gerontological concept, including genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, microbiome dysbiosis, extracellular matrix stiffness and barrier dysfunction, as well as circadian rhythm disruption.</p><p><strong>Results: </strong>A comprehensive system of 30+biomarkers with detailed reference and target values is presented. Key biomarkers include: urinary 8-OHdG (target values<5.0 ng/mg creatinine), leukocyte telomere length (target >6000 base pairs), N7-methylguanine (<6-7 μg/g creatinine), dityrosine (≤10-12 μmol/mol creatinine), p62 and Beclin-1 for autophagy assessment, HOMA-IR (<1.5), IGF-1 (100-150 ng/ml), mitochondrial markers, senescence-associated β-galactosidase (<3% positive cells), inflammatory cytokines, microbiome-associated markers, and circadian biomarkers.</p><p><strong>Conclusion: </strong>The developed biomarker panel provides a scientifically grounded foundation for personalized assessment of aging rate and correction of age-associated changes, requiring regular monitoring every 3-6 months for effective interpretation of biomarker dynamics.</p>","PeriodicalId":39492,"journal":{"name":"Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury","volume":"102 5. Vyp. 2","pages":"108-119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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