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Compact organ-tissue electrophoresis system (CORES). 紧凑型器官组织电泳系统(CORES)。
Q3 Engineering Pub Date : 2023-10-01 Epub Date: 2024-04-08 DOI: 10.1080/03091902.2024.2336497
Aysegul Gungor Aydin, Erdinc Sahin Conkur, Esat Adiguzel

Electrophoretic tissue clearing has been a commonly used laboratory method since the early twentieth century. Infrastructure for standard procedures has yet to be formed. In particular, control of the heat produced by electrophoresis, the voltage applied to the electrodes, the resistance, and the speed of liquid circulation create difficulty for researchers. We aimed to develop a compact organ electrophoresis system that enables the researcher to have easy, rapid, and inexpensive working opportunities. The system includes an electronic control unit, a liquid tank, a temperature control unit, and an electrophoresis chamber. The control unit software can keep the system stable by using information on temperature and circulation rate received through the sensors using the feedback principle. Corrosion and particle collection are reduced to a minimum as platinum wires are used for electrophoresis electrodes. A temperature control unit can heat and cool via a liquid tank base. The CORES is an all-in-one, easy-to-use solution for electrophoretic tissue clearing. It assures efficient, rapid, and consistent tissue clearing. The system was stable with 72 h of continuous operation. Patent applications and trial version studies for introducing the system to researchers are still in progress.

自二十世纪初以来,电泳组织清理一直是一种常用的实验室方法。标准程序的基础设施尚未形成。特别是对电泳产生的热量、施加在电极上的电压、电阻和液体循环速度的控制给研究人员造成了困难。我们的目标是开发一种结构紧凑的器官电泳系统,使研究人员能够获得简便、快速和廉价的工作机会。该系统包括一个电子控制单元、一个液体槽、一个温度控制单元和一个电泳槽。利用反馈原理,控制单元软件可通过传感器接收到的温度和循环速率信息保持系统稳定。由于电泳电极使用的是铂丝,因此可将腐蚀和微粒收集降到最低程度。温度控制装置可通过液槽底座进行加热和冷却。CORES 是一种一体化、易于使用的电泳组织清除解决方案。它能确保高效、快速、稳定地清除组织。该系统可连续稳定运行 72 小时。向研究人员介绍该系统的专利申请和试用版研究仍在进行中。
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引用次数: 0
Feasibility study of femur bone with continuum model. 利用连续模型对股骨头进行可行性研究。
Q3 Engineering Pub Date : 2023-10-01 Epub Date: 2024-04-16 DOI: 10.1080/03091902.2024.2336512
Kianoosh Abbassi, Maziar Janghorban, Farshad Javanmardi, Saleh Mobasseri

It is known that the geometric structures of bones are very complex. This has made researchers unable to model them with the continuum approach and suffice to model them with simulation or experimental tests. Undoubtedly, provide a simple and accurate continuum model for studying bones is always desirable. In this article, as the first serious endeavour, a suggested beam model is investigated to see whether it is suitable for modelling femur bones or not. If this model gives an acceptable answer, it can be a link to the continuum theories for beams. In other words, the approximated beam model can be formulated with continuum approach to study femur bone. For feasibility study of the approximated model for femur bones, both static and dynamic analysis of them are investigated and compared. It is found that in most cases for vibration analysis, the suggested model has acceptable results but in static analysis, the mean difference between the results is about 16%. This research is hoped to be the first serious step in this category.

众所周知,骨骼的几何结构非常复杂。这使得研究人员无法用连续方法对其进行建模,而只能通过模拟或实验测试对其进行建模。毫无疑问,为研究骨骼提供一个简单而精确的连续体模型一直是人们所期望的。在本文中,作为第一次认真的尝试,我们研究了一个建议的梁模型,看看它是否适合股骨头建模。如果该模型给出了可接受的答案,那么它就可以与梁的连续性理论联系起来。换句话说,近似梁模型可以用连续体方法来研究股骨头。为了研究股骨近似模型的可行性,我们对其进行了静态和动态分析,并进行了比较。结果发现,在振动分析的大多数情况下,所建议的模型具有可接受的结果,但在静态分析中,结果之间的平均差异约为 16%。希望这项研究能在这一领域迈出重要的第一步。
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引用次数: 0
News and product update. 新闻和产品更新。
Q3 Engineering Pub Date : 2023-08-31 DOI: 10.1080/03091902.2023.2243191
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引用次数: 0
Artificial intelligence and machine learning responses to COVID-19 related inquiries. 人工智能和机器学习对 COVID-19 相关询问的答复。
Q3 Engineering Pub Date : 2023-08-01 Epub Date: 2024-04-16 DOI: 10.1080/03091902.2024.2321846
Naser Zaeri

Researchers and scientists can use computational-based models to turn linked data into useful information, aiding in disease diagnosis, examination, and viral containment due to recent artificial intelligence and machine learning breakthroughs. In this paper, we extensively study the role of artificial intelligence and machine learning in delivering efficient responses to the COVID-19 pandemic almost four years after its start. In this regard, we examine a large number of critical studies conducted by various academic and research communities from multiple disciplines, as well as practical implementations of artificial intelligence algorithms that suggest potential solutions in investigating different COVID-19 decision-making scenarios. We identify numerous areas where artificial intelligence and machine learning can impact this context, including diagnosis (using chest X-ray imaging and CT imaging), severity, tracking, treatment, and the drug industry. Furthermore, we analyse the dilemma's limits, restrictions, and hazards.

最近,人工智能和机器学习取得了突破性进展,研究人员和科学家可以利用基于计算的模型将关联数据转化为有用信息,从而帮助疾病诊断、检查和病毒遏制。在本文中,我们广泛研究了人工智能和机器学习在 COVID-19 大流行开始近四年后的高效应对中发挥的作用。在这方面,我们研究了多个学科的学术和研究团体开展的大量重要研究,以及人工智能算法的实际应用,这些算法为调查不同的 COVID-19 决策场景提出了潜在的解决方案。我们确定了人工智能和机器学习可对这一背景产生影响的众多领域,包括诊断(使用胸部 X 光成像和 CT 成像)、严重程度、跟踪、治疗和制药业。此外,我们还分析了这一困境的局限性、限制和危害。
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引用次数: 0
Small-scale medical oxygen production unit using PSA technology: modeling and sensitivity analysis. 使用 PSA 技术的小型医用氧气生产装置:建模和敏感性分析。
Q3 Engineering Pub Date : 2023-08-01 Epub Date: 2024-04-16 DOI: 10.1080/03091902.2024.2331693
Lina Benkirane, Abdessamad Samid, Tarik Chafik

This study presents a solid approach for small-scale medical oxygen production unit using pressure swing adsorption (PSA) technology. The objective of this research is to develop a mathematical model and conduct a sensitivity analysis to optimise the design and operating parameters of the PSA system. Based on the simulation results, an optimal set of operational parameter values has been obtained for the PSA beds. The result shows that the binary system produced oxygen with a purity of 94%, at the adsorption pressure 1 bar and temperature of 308K. The findings demonstrate the effectiveness of the proposed small-scale PSA system for medical oxygen production, highlighting the impact of key parameters and emphasising the need for careful optimisation. The findings serve as a guide for the design and operation of small-scale PSA systems, enabling healthcare facilities to produce their own medical oxygen, thereby improving accessibility and addressing critical shortages during emergencies. Future research may explore the integration of large scale PSA units in hospitals in Morocco.

本研究提出了一种利用变压吸附(PSA)技术生产小型医用氧气的可靠方法。这项研究的目的是建立一个数学模型并进行敏感性分析,以优化 PSA 系统的设计和运行参数。根据模拟结果,得出了 PSA 床的一组最佳运行参数值。结果表明,在吸附压力为 1 巴、温度为 308K 的条件下,二元系统产生的氧气纯度为 94%。研究结果表明,拟议的小规模 PSA 系统在医用氧气生产方面非常有效,突出了关键参数的影响,并强调了仔细优化的必要性。这些研究结果为小型 PSA 系统的设计和运行提供了指导,使医疗机构能够生产自己的医用氧气,从而提高了可及性,并解决了紧急情况下的严重短缺问题。未来的研究可能会探索在摩洛哥的医院中整合大型 PSA 设备。
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引用次数: 0
Enhanced skin burn assessment through transfer learning: a novel framework for human tissue analysis. 通过迁移学习加强皮肤烧伤评估:人体组织分析的新框架。
Q3 Engineering Pub Date : 2023-07-01 Epub Date: 2024-03-22 DOI: 10.1080/03091902.2024.2327459
Madhur Nagrath, Ashutosh Kumar Sahu, Nancy Jangid, Meghna Sharma, Poonam Chaudhary

Visual inspection is the typical way for evaluating burns, due to the rising occurrence of burns globally, visual inspection may not be sufficient to detect skin burns because the severity of burns can vary and some burns may not be immediately apparent to the naked eye. Burns can have catastrophic and incapacitating effects and if they are not treated on time can cause scarring, organ failure, and even death. Burns are a prominent cause of considerable morbidity, but for a variety of reasons, traditional clinical approaches may struggle to effectively predict the severity of burn wounds at an early stage. Since computer-aided diagnosis is growing in popularity, our proposed study tackles the gap in artificial intelligence research, where machine learning has received a lot of attention but transfer learning has received less attention. In this paper, we describe a method that makes use of transfer learning to improve the performance of ML models, showcasing its usefulness in diverse applications. The transfer learning approach estimates the severity of skin burn damage using the image data of skin burns and uses the results to improve future methods. The DL technique consists of a basic CNN and seven distinct transfer learning model types. The photos are separated into those displaying first, second, and third-degree burns as well as those showing healthy skin using a fully connected feed-forward neural network. The results demonstrate that the accuracy of 93.87% for the basic CNN model which is significantly lower, with the VGG-16 model achieving the greatest accuracy at 97.43% and being followed by the DenseNet121 model at 96.66%. The proposed approach based on CNN and transfer learning techniques are tested on datasets from Kaggle 2022 and Maharashtra Institute of Technology open-school medical repository datasets that are clubbed together. The suggested CNN-based approach can assist healthcare professionals in promptly and precisely assessing burn damage, resulting in appropriate therapies and greatly minimising the detrimental effects of burn injuries.

肉眼检查是评估烧伤的典型方法,但由于全球烧伤发生率不断上升,肉眼检查可能不足以发现皮肤烧伤,因为烧伤的严重程度可能各不相同,有些烧伤肉眼可能无法立即察觉。烧伤可造成灾难性后果,使人丧失工作能力,如果不及时治疗,可导致疤痕、器官衰竭,甚至死亡。烧伤是相当高发病率的一个重要原因,但由于各种原因,传统的临床方法可能难以有效地在早期预测烧伤伤口的严重程度。由于计算机辅助诊断越来越受欢迎,我们提出的研究解决了人工智能研究中机器学习受到广泛关注,而迁移学习受到较少关注的空白。在本文中,我们介绍了一种利用迁移学习提高 ML 模型性能的方法,展示了它在各种应用中的实用性。迁移学习方法利用皮肤烧伤的图像数据估计皮肤烧伤的严重程度,并利用结果改进未来的方法。DL 技术由一个基本 CNN 和七个不同的迁移学习模型类型组成。使用全连接前馈神经网络将照片分为显示一级、二级和三级烧伤的照片以及显示健康皮肤的照片。结果表明,基本 CNN 模型的准确率为 93.87%,明显偏低,VGG-16 模型的准确率最高,达到 97.43%,其次是 DenseNet121 模型,为 96.66%。基于 CNN 和迁移学习技术的建议方法在 Kaggle 2022 数据集和马哈拉施特拉邦理工学院开放学校医学资料库数据集上进行了测试。所建议的基于 CNN 的方法可以帮助医护人员及时、准确地评估烧伤损伤,从而采取适当的治疗措施,并大大减少烧伤的不利影响。
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引用次数: 0
A new approach to phonocardiogram severity analysis. 心电图严重程度分析的新方法。
Q3 Engineering Pub Date : 2023-07-01 Epub Date: 2024-02-23 DOI: 10.1080/03091902.2024.2310157
Debbal Imane, Hamza Cherif Lotfi, Baakek Yettou Nour El Houda

Phonocardiogram signal (PCG) has been the subject of several signal processing studies, where researchers applied various analysis techniques and extracted numerous features for different purposes, like cardiac pathologies identification, healthy/pathologic case discrimination, and severity assessment. When talking about cardiac severity, many think directly about the intensity or energy of the signal as the most reliable parameter. However, cardiac severity is not always reflected by the intensity or energy of the signal but includes other variables as well. In this paper, we will discuss the probability of having a Discrete Wavelet Transform (DWT) parameter that discriminates, identifies, and assesses the pathological cardiac severity levels, a parameter that takes into consideration other variables and elements for the severity study. For this purpose, we studied six PCGs signals that contain reduced murmurs (clicks) and eight murmur signals with four different cardiac severity levels. We extracted the Entropy of Approximation Coefficients (EAC) from the Discrete Wavelet Transform (DWT) sub-bands as the feature to study in this novel approach. The Energetic Ratio (ER) served as a reference parameter to evaluate the EAC evolution, due to its proven efficiency in cardiac severity tracking. While the DWT-EAC algorithm results revealed that the EAC provides better results for the paper purposes, the One versus All Support Vector Machine (OVA-SVM) classifier affirmed the efficiency of the Entropy of Approximation Coefficients (EAC) for cardiac severity assessment and proved the accuracy of this novel approach.

心电图信号(PCG)一直是多项信号处理研究的主题,研究人员应用了各种分析技术并提取了大量特征,用于不同的目的,如心脏病理识别、健康/病理病例鉴别和严重程度评估。在讨论心脏严重程度时,许多人直接将信号强度或能量视为最可靠的参数。然而,心脏严重程度并不总是由信号强度或能量来反映,还包括其他变量。本文将讨论离散小波变换 (DWT) 参数区分、识别和评估病理心脏严重程度的可能性,该参数考虑了严重程度研究的其他变量和元素。为此,我们研究了六种包含减弱杂音(咔嗒声)的 PCG 信号和八种杂音信号,这八种杂音信号具有四种不同的心脏严重程度。我们从离散小波变换(DWT)子带中提取了近似系数熵(EAC),作为这种新方法的研究特征。能量比 (ER) 是评估 EAC 演变的参考参数,因为它在心脏严重程度跟踪方面的效率已得到证实。DWT-EAC 算法的结果表明,EAC 为本文提供了更好的结果,而支持向量机(OVA-SVM)分类器则肯定了近似系数熵(EAC)在心脏严重程度评估中的效率,并证明了这种新方法的准确性。
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引用次数: 0
Applying user-centered design and the Pi-CON methodology for vital signs sensor development. 在生命体征传感器开发中应用以用户为中心的设计和 Pi-CON 方法。
Q3 Engineering Pub Date : 2023-07-01 Epub Date: 2024-03-12 DOI: 10.1080/03091902.2024.2325964
Steffen Baumann, Richard T Stone

Although telehealth, and in particular RPM, have demonstrated to drive many benefits, such as reduction in cost and hospital-acquired infections, previous research has shown many usability challenges when patients operate a medical device without supervision of a medical professional. To combat this issue, the Pi-CON methodology is applied to develop a novel sensor with the objective to continuously acquire a patient's vital signs from a distance, without the need to attach any markers or sensors to the patient, and with limited user interaction required. Pi-CON stands for passive, continuous and non-contact, and describes a way to improve the user experience for patients or caregivers that have a need to perform a vital signs measurement themselves, without the presence of a medical professional. The developed sensor utilises radar and optical sensing technologies and transmits acquired data to a cloud-based service where it can be viewed in near real-time by the patient or family members from anywhere via an intuitive user interface. This user interface, as well as the sensor itself were designed based on design needs and requirements to adhere to the user-centered design process. The development of the sensor, including utilised technologies, components, and the user interface are presented, including inspirations for future work.

虽然远程医疗,特别是远程医疗转运(RPM)已被证明能带来许多好处,如降低成本和减少医院感染,但以往的研究表明,当病人在没有专业医务人员的监督下操作医疗设备时,存在许多可用性方面的挑战。为解决这一问题,我们采用 Pi-CON 方法开发了一种新型传感器,旨在远距离连续采集病人的生命体征,无需在病人身上安装任何标记或传感器,而且只需与用户进行有限的互动。Pi-CON 是被动、连续和非接触的缩写,它描述了一种改善用户体验的方法,即病人或护理人员需要在没有专业医务人员在场的情况下自己进行生命体征测量。所开发的传感器利用雷达和光学传感技术,将获取的数据传输到云端服务,病人或家属可在任何地方通过直观的用户界面近乎实时地查看这些数据。该用户界面以及传感器本身都是根据设计需求和要求设计的,符合以用户为中心的设计流程。本文介绍了传感器的开发过程,包括所使用的技术、组件和用户界面,以及对未来工作的启发。
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引用次数: 0
News and product update 新闻和产品更新
Q3 Engineering Pub Date : 2023-06-19 DOI: 10.1080/03091902.2023.2219546
Click to increase image sizeClick to decrease image size Disclosure statementThe News and Product Update is compiled and edited by Dr J Fenner. The author reports no conflict of interest with the contents, products or manufacturers featured in the News and Product Update, unless stated otherwise.
点击放大图片点击缩小图片披露声明《新闻与产品更新》由J·芬纳博士编辑。除非另有说明,作者报告与新闻和产品更新中的内容,产品或制造商没有利益冲突。
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引用次数: 0
News and Product Update. 新闻和产品更新。
Q3 Engineering Pub Date : 2023-05-10 DOI: 10.1080/03091902.2023.2198436
John Fenner
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引用次数: 0
期刊
Journal of Medical Engineering and Technology
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