Neuropsychopharmacologia Hungarica最新文献

Our study presents the Hungarian adaptation of the Mental Health Quality of Life Questionnaire (MHQoL).

Background: In recent decades, there has been a shift in the field of healthcare, with a notable change in the ultimate goal of health interventions. Rather than merely reducing symptoms and prolonging life, the objective of health interventions is now to improve quality of life. A number of measures of quality of life have been developed, but the majority of these focus exclusively on physical health and do not fully cover the dimensions that are relevant to the quality of life of people with mental health problems. Van Krugten et al. have developed the Mental Health Quality of Life (MHQoL) questionnaire, which covers the seven most important dimensions of mental health-related quality of life.

Objectives: Our research had the following two main aims. Firstly, it aimed to develop and test a Hungarian adaptation of the Mental Health Quality of Life (MHQoL) questionnaire. Secondly, it aimed to compare the results of healthy individuals and those with diagnosed psychiatric disorders.

Methods: A total of 189 individuals participated in the survey, with 157 classified as psychiatrically healthy and 32 diagnosed with a mental disorder, of which 20 were in acute psychiatric care and 12 were in outpatient care. The data were analysed using confirmatory factor analysis, reliability analysis and independent samples t-test.

Results: Our confirmatoriy factor analysis indicated that all items show a good fit with the model. The factor weights for each item were observed to range from 0.45 to 0.79. The Cronbach's α index obtained in our reliability analysis of the MHQoL demonstrated exceptional internal reliability: an index value of 0.81, with individual item- specific reliability coefficients ranging from 0.7 to 0.81. Independent samples t-tests were conducted to assess the statistical significance of differences in mean scores between respondents with and without a psychiatric diagnosis. The results indicated that there were significant differences in the means of the two groups for items pertaining to future vision, mood, relationships and physical health, as well as when comparing the mean scores of the MHQoL total score and the mean scores of psychological well-being. The majority of variables exhibited statistically significant differences from each other, with medium effect sizes.

Conclusions: The results thus far indicate that the Hungarian version of the MHQoL is an effective instrument for differentiating between individuals with and without mental illness, based on psychometric indicators. Furthermore, it provides valuable insights into the domains in which psychiatric illnesses have the greatest impact on patients' quality of life. The objective of our future research is to further validate the MHQoL questionnaire in order to

Even the Kraepelinian concept of dementia praecox suggests a link between schizophrenia and various cognitive deficits. Although cognitive impairment is not a fundamental symptom of schizophrenia, it is considered to be one of the basic features of the disease. The deficit can affect a number of cognitive domains and is most often specific. One of the most pronounced cognitive symptoms of schizophrenia is impairment in attentional and executive functions. The Trail Making Test (TMT) is a screening test commonly used in the clinic that is very sensitive to impairments in attention and executive functions. The aim of the present study is to summarise the research conducted in the last five years in which the Trail Making Test has been used to screen schizophrenics. A search was conducted in the PubMed database using the keywords "schizophrenia" and "Trail Making Test". A total of 43 relevant studies have been published on this topic since 2018. A review of the research on this topic shows that the TMT can be used to identify cognitive deficits in schizophrenics, affecting executive functions and attention. It also shows that schizophrenic patients performed significantly worse on the test than healthy individuals.

Major mood disorder (i.e. major depressive disorder [MDD] and bipolar disorders [BPDs]) are among the most prevalent and disabling mental illnesses. Several, frequently intertwining theories (such as the monoamine, neuroinflammatory and neurotrophic theories) exist to explain the etiopathogenic background of mood disorders. A lesser-known hypothesis addresses the role of oxidative stress (OS; i.e. the overproduction and accumulation of free radicals) in the pathogenesis of these mental disorders. Free radicals are capable of damaging phospholipids, polyunsaturated fatty acids, proteins and nucleic acids. In the brain, OS impairs inter alia synaptic signalling and neuroplasticity. In the current paper, in addition to a brief description of the aforementioned pathophysiological processes involved in mood disorders (with a special focus on OS), we discuss in detail the results of studies on changes in non-enzymatic antioxidant uric acid (UA) levels in major mood disorders. Findings to date indicate that UA - a routinely measured laboratory parameter - may be a candidate biomarker to distinguish between MDD and BPD. Since the diagnostic criteria are identical for major depressive episodes regardless of whether the episode occurs in the context of MDD or BPD and also bearing in mind that the treatment for those two disorders is different, we may conclude that the identification of biomarkers to enable MDD to be distinguished from BPD would be of great clinical relevance.

Background and objective: Care for family members is a significant characteristic of families in South Asia. A family is one unit, and every other member is emotionally connected and expected to take care of each other. However, the provision of care to a family member with mental illness can be physically as well as emotionally exhausting and distressing for the Family Caregiver. The present study aimed to investigate the caregiving burden in family caregivers of depression and schizophrenia.

Method: For this cross-sectional research, a purposive sample of 80 Family caregivers taking care of at least one family member with mental health problems of depression (n=40) and schizophrenia (n=40) were recruited for the present study. The age range of the sample was 15 to 60 years. All the respondents were literates who could read and write in Urdu. The scale used to measure the caregiving burden was Zarit Caregiving Burden Scale. The data was collected from the male (n=22) and female (n=58) family caregivers. To access data, family caregivers were approached at the psychological services clinics of Rawalpindi and Islamabad in private and public sector hospitals.

Results: The data were analyzed through descriptive and t-test analysis. Analyses of the data revealed that family caregivers of schizophrenia had a greater caregiving burden as compared to family caregivers of depression. Results also showed that females reported a higher caregiving burden as compared to male family caregivers.

Conclusion: Family caregivers of schizophrenia undergo the severe burden of care and distress, and they may be considered a high-risk group for the development of mental health problems. Comprehensive intervention programs may be developed to involve them and safeguard their mental health.

Introduction: Compulsive sexual behaviour or hypersexuality has been the subject of growing interest among academic circles. However, relatively few reliable predictors have been identified. The aim of the present study was to examine whether different types of sexual motivations based on Self-Determination Theory can account for compulsive sexual behaviour.

Method: The study was conducted on a non-clinical sample of nearly 1000 participants. Sexual motivation was assessed using the Sexual Motivation Scale and compulsive sexual behaviour was assessed using the Hypersexual Behaviour Inventory. Both measures showed adequate reliability. Multiple linear regression was performed to analyse the relationship between the variables.

Results: In the regression, controlling for gender, of the six motivational factors, integrated (β = 0.167), introjected (β = 0.074) and amotivation (β = 0.128) were found significant (p <0.001), and identified was nearly significant (β = 0.53; p = 0.065). The intrinsic (β = -0.032; p = 0.366) and extrinsic (β = -0.027; p = 0.168) forms of motivation had no impact on hypersexuality. The total explained variance of the model was 18% (p <0.001). Results indicated that three of the six motivational factors positively and weakly predicted hypersexuality.

Conclusion: The original hypothesis of the study, that less self-determined motivated sexual behaviour would be a better predictor of compulsive sexual behaviour, was not confirmed. In practice, positively related variables, especially amotivation, may play an important role in psychotherapeutic processes. However, in order to better understand compulsive sexual behaviour, additional factors still need to be explored.

Aims: This paper aims to describe Roger Mulder's presentation on borderline personality disorder organized by the 23rd World Congress of Psychiatry, supplemented with relevant research results.

Methods: Mulder presents the diagnostic criteria of borderline personality disorder, its comorbidity, therapeutic considerations and the phenomenon of stigmatization related to the disorder.

Results: According to Mulder, the diagnostic criteria of borderline personality disorder are vague and it shows a very high comorbidity with other psychiatric disorders. Mulder draws attention to the fact that it was not possible to identify a borderline factor in previous research because the borderline symptoms disappeared during the analysis in a general ("g") personality disorder factor. According to Mulder, there is no specific psychotherapy that is effective only in borderline personality disorder, and the pharmacological treatment has also not proven to be effective in treating the core symptoms of borderline personality disorder. According to Mulder, the stigma associated with the diagnosis of borderline personality disorder hinders the recognition and treatment of other psychiatric or somatic difficulties of patients.

Conclusion: according to Mulder, based on modern scientific standards, borderline personality disorder has no place in the classification, however, specialists still insist on the diagnosis.

Introduction: Intolerance of uncertainty is the tendency to react negatively to an uncertain situation, regardless of the probability of the occurrence of the event and its consequences. Intolerance of uncertainty (IU) can also be conceptualized as a personality trait that is prominent in many anxiety and rumination-related pathologies. A growing body of research highlights its key role in understanding anxiety disorders.

Method: The aim of present study was to investigate the dimensionality, validity and reliability of the Intolerance of Uncertainty Scale in a large non-clinical sample (N = 1747). Former was analysed by confirmatory factor analysis, the validity by correlation with the Perceived Stress Scale. Reliability was assessed using Cronbach's alpha coefficient and test-retest analysis.

Results: Confirmatory factor analysis failed to confirm the hypothesized two-factor structure (CFI = 0.907; TLI = 0.885; RMSEA = 0.103 [90% CI = 0.096-0.110]; SRMR = 0.071). However, the exploratory factor analysis identified the same two factors as in the original study: "Prospective" and "Inhibitory". The scale showed excellent internal reliability (α = 0.897) and test-retest reliability. There was moderate correlation with the Perceived Stress Scale (r = 0.438).

Conclusion: Based on the results, the Hungarian version of the BTS-12 is a valid and reliable measurement tool. However, before its use in a Hungarian sample, its psychometric properties need to be confirmed by further studies on a large sample. In the future, the questionnaire will be useful in measuring intolerance of uncertainty and may be useful in identifying susceptibility to anxiety disorders.

Objective: The literature suggests that mentalizing deficits, insecure attachment, and higher levels of perceived stress are closely linked, however, the association between these constructs has not yet been investigated among Hungarian adults. In our study, we investigated the relationship between mentalization, attachment and perceived stress in a non-clinical adult sample.

Methods: In our study, 255 adults completed the Reflective Functioning Questionnaire (RFQ-R-7), the Experiences in Close Relationships questionnaire (ECR-R-HU) and the Perceived Stress Scale (PSS) after informed consent. In our analysis, we tested two simple mediation models. The independent variables differed in the two analyses, in the first one we used the attachment anxiety subscale, while in the second one, we used the attachment avoidance subscale of the ECR-R-HU questionnaire. In both of our models, the perceived stress (PSS) was the dependent variable, while hypomentalization was the mediator (RFQ7).

Results: The models were found to be significant. The direct path between attachment anxiety and perceived stress (c' = 0.11, p < .001, β = 0.29) and indirect path through hypomentalizig also proved to be significant (∑ab = 0.04 [0.02 - 0.06], β = 0.10). The direct path between attachment avoidance and perceived stress was significant (c' = 0.05, p = 0.04, β = 0.12), however, the indirect path between attachment avoidance and perceived stress was not significant (∑ab = -0.004 [-0.02 - 0.01], β = -0.01).

Conclusions: Our results - taking our limitations into account - suggest that hypomentalization has a mediational effect on the relationship between attachment anxiety and perceived stress, while attachment avoidance is directly related to perceived stress. Our results have important practical implications for prevention and intervention.

Background/objectives: David P. Bernstein's model of personal strengths was born out of the interaction of schema theory and positive psychology. According to Bernstein, the strengths of a healthy adult self can be described along four dimensions: self-directedness, self-regulation, connectedness, and transcendence. Previous research has shown that attention- deficit/hyperactivity disorder (ADHD) in adults is associated with higher levels of perceived stress, but the role of personal strengths in this context has not yet been investigated. The aim of our study was to explore the role of Bernstein's strength dimensions in the relationship between adult ADHD symptoms and perceived stress, using a dimensional approach in a non-clinical sample.

Method: Our online questionnaire, which included the Bernstein Strengths Scale (BSS), the Adult ADHD Self-Report Scale (ASRS), and a shortened version of the Perceived Stress Scale (PSS4), was completed by 100 adults (mean age 38.25 years, standard deviation 5.73 years) after informed consent.

Results: In the bivariate analysis, the ASRS showed a significant negative association with the BSS dimensions, with a large effect size for self-regulation and a medium effect size for the other dimensions. On the other hand, the PSS4 scale showed significant negative correlations with all four strength dimensions, with effect sizes large for self-direction and self-regulation and medium for the connection and transcendence dimensions. Personal strengths mediated the relationship between ADHD symptoms and perceived stress.

Discussion: Our results suggest that ADHD symptoms may be associated with a deficit in personal strengths, which may contribute to negative outcomes. Psychotherapeutic interventions that support the recognition, cultivation and mobilization of strengths may be useful in the treatment of adults diagnosed with ADHD.

Objective: We investigated the relationship between mentalisation, attachment and resilience in an adult sample.

Method: 225 people completed the Reflective Function Questionnaire (RFQ-H), the Experiences in Close Relationships Questionnaire (ECR-R-HU), and the Connor-Davidson Resilience Questionnaire (CD-RISC) in our non-clinical study after informed consent. The analysis was controlled for gender of the respondents.

Results: The models were found to be significant in the mediator analysis. The path between attachment total score and hypomentalisation was significant (a=2.88, p<0.01, β=0.32). The direct path between attachment total score and resilience was found to be significant (c'=-2.00, p<0.001, β=-0.28). The relationship between hypomentalisation and resilience was also significant (b=-0.30, p<0.01, β=-0.38). The indirect pathway between attachment and resilience through hypomentalisation was found to be significant (∑ab=-0.87 [-1.41 - -0.40], β = 0.12). Thus, a high total attachment score through higher levels of hypomentalisation predicts lower resilience. Based on the standardized regression coefficients, hypomentalisation was the strongest predictor of resilience, and attachment was more strongly associated with resilience via direct than indirect means via hypomentalisation.

Conclusions: Our results suggest - considering the limitations of our research - that attachment is related to resilience through mentalisation, and that mentalisation itself is a strong predictor of resilience. The practical implication of our results is that the use of mentalisation-based methods may be worth considering for individuals with lower levels of resilience.