Neuropsychopharmacologia Hungarica最新文献

Aims: This study sought to synthesize prevalence rates of problematic internet use (PIU) during the COVID-19 pandemic in the general adult (age over 18 years old) population and to investigate its possible moderators.

Methods: A preregistered systematic literature review using the PubMed/MEDLINE, EBSCOhost/PsycINFO, Web of Science, Cochrane Library, GSK Clinical Study Register, and ClinicalTrials.gov databases was conducted. Research was completed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 checklist.

Results: A total of 22 publications were identified, fulfilling inclusion criteria from a total of 595 studies. The analysis revealed that the prevalence of PIU during the COVID-19 pandemic period was 25%, however applying a stringent threshold for the PIU, resulted in a much lower prevalence of 7.9%.

Conclusion: The PIU prevalence rate during the COVID-19 pandemic in the general population was 7.9%. Measuring the prevalence of PIU remains complicated due to the large methodological and cultural diversity that exists, so global prevalence estimates of PIU vary substantially. More methodologically sound research on psychodiagnostic assessment and cultural variances is required. (Neuropsychopharmacol Hung 2023; 25(3): 131-141) Keywords: COVID-19; internet addiction; problematic usage of the internet; prevalence; systematic review, meta-analysis Systematic review registration: PROSPERO registration number: CRD42021284619.

Infertility can be caused by several factors, thus the effective treatment of infertility is a complex and multidisciplinary task. While psychological support is an essential part of infertility treatment, there is growing evidence that the role of psychological factors is much greater, as personality and psychological factors have a significant impact on the development, long-term course, and treatment success of several somatic diseases. Exploring the possible mechanisms through which these psychological factors directly or indirectly contribute to infertility and the success of infertility interventions could help identify high-risk patient groups and tailor treatment to the patient, which may increase the chances of successful pregnancy and live birth in women undergoing assisted reproductive treatment. In this review we aim to summarize current knowledge and research findings on the relationship between psychological factors and infertility treatments, including clinical consequences and implications for future research. Keywords: infertility, assisted reproduction, IVF, adherence, personality, temperaments, affective temperaments, TEMPS-A, stress, depression.

In recent years, the question of how we can grasp the ability to plan future events has come to the forefront in light of the retrieval of personal memories from the past. If episodic memory is responsible for envisioning future events, there appears to be an overlap between autobiographical memory and imagining the future. The aim of this current narrative literature review is to present existing theories and research findings, thereby facilitating the development of an organizational framework necessary for the unified investigation of future thinking. This article introduces the neural network processes underlying episodic future thinking, with particular emphasis on the significance of the hippocampus. It outlines the constructive episodic simulation hypothesis, suggesting that episodic memory and episodic future thinking largely rely on similar neural substrates and assumes that a primary function of the episodic memory system is to flexibly reorganize units of individual, contextual memories to simulate possible future events for the individual. The article presents research results related to memory deficits, as it can be presumed that impairment of autobiographical memory in psychiatric disorders also results in impaired episodic future thinking. Future-oriented thoughts serve various functions, such as decision-making, action planning, and emotional regulation. The article also delves into schema theories, as when generating episodic future thoughts, people often activate their general knowledge about their personal future before a specific event occurs. Future thinking is crucial for well-being, goal attainment, aging, optimism, and understanding clinical conditions. How people think about the future can influence their decisions. The elucidation of emotionally futureoriented thoughts, autobiographical knowledge structures, and life-history schemas plays a crucial role in the construction of episodic future thinking. Understanding the role of memory in simulating future events can be important in comprehending the constructive nature of memory and, in general, the functioning of memory systems in diseases, thereby contributing to the specific selection of treatments for these conditions.

Background/aims: Adult attention-deficit/hyperactivity disorder (ADHD) affects parental functioning which in turn has an impact on the off spring's psychopathology. The aim of this meta-analysis was to assess the relationship between parental ADHD symptoms and parental behaviour, focusing on comparative evaluation of studies using self-report and behavioural observation.

Method: A systematic literature search was conducted in three databases (Web of Science, PubMed, Scopus) resulting 13 studies and 87 effect-sizes (N = 2018) for a metaanalysis. We used random effect model, assessed heterogeneity, and evaluated the possibility of publication bias. We conducted subgroup analyses by method of assessing parental behaviour (self-report/observation), valence of parental behaviour (positive/negative), domain of negative parental behaviour (inconsistent discipline, hostility, corporal punishment), and ADHD symptom clusters (inattention, hyperactivity/impulsivity, combined). Meta-regression analyses were conducted to explore the eff ect of children's mean age, the ratio of mothers in the parent sample, and the ratio of boys and ADHD diagnosis in the children's sample.

Results: The mean effect size of the association of self-reported parental behaviour and ADHD symptoms was small but significant, higher levels of parental ADHD symptoms were related to higher levels of negative and lower levels of positive parental behaviour. The analysis did not suggest a publication bias. The effect was robust across ADHD symptom clusters. Children's mean age, the ratio of mothers in the parent sample, and the ratio of boys and ADHD diagnosis in the children's sample did not have a significant effect. On the other hand, behavioural observation of parental behavior was not related to parental ADHD symptoms.

Conclusion: Our results underlie the importance of methodology of assessing parental behaviour. Multi-method and multi-informant assessment in parenting research is warranted.

The author presents a new psychosomatic stress model. All the elements of the hypothesis are well known but, in this context, are published first. The following are the most critical aspects of the recommended chronic stress model. 1/ Stress contains both sympathetic and parasympathetic elements, but the latter predominate. 2/ The mediator of stress is carbon dioxide, the substance that can turn the psyche into soma. 3/ In humans, chronic stress is mainly social; people cause it to each other. Chronic social stress is created frequently due to deviations in civilisation, education and tolerance. 4/ The freeze response (or freezing behaviour) plays a subordinate role in the animal world; it lasts mainly for a maximum of minutes, while in humans, it dominates and can continue for decades. 5/ The decisive step of freeze is apnea, hypopnea, which occurs due to aversive psychological eff ects. After a more extended existence, mild chronic respiratory acidosis develops and most often appears in the clinical form of obstructive sleep apnea. 6/ Chronic hypercapnia can shape the metabolism into metabolic syndrome. 7/ After that, various cardiovascular and metabolic complications (hypertension, atherosclerosis, type 2 diabetes, depression) may develop - partly due to genetic and lifestyle reasons. (Neuropsychopharmacol Hung 2022; 24(3): 126-133).

In their recently published systematic "umbrella" review, Moncrieff and colleagues conclude that there is no consistent evidence that depression is caused by decreased serotonin activity in the central nervous system (CNS). However, this paper - which was extensively publicized and received a lot of attention on the social media - can cause misunderstandings, since the serotonin hypothesis of depression in its original form (i.e. reduced serotonin activity in the CNS = depression) formulated more than 50 years ago has been considered outdated for several decades. It has long been known that depression is a heterogeneous disorder not only genetically, clinically and biologically but also from a pharmacotherapeutic perspective. The decreased activity of serotonin, which undoubtedly plays an essential role in the pathogenesis of depression, is characteristic of only a subgroup of depressed subjects whose clinical picture is mostly dominated by intensified negative emotions, agitation, anxiety, insomnia, decreased appetite, self-blame and suicidality and these individuals are primarily responsive to SSRIs. By contrast, depression cases with reduced positive affects (characterized by anhedonia, anergia, inhibition and reduced cognitive functions) are mainly caused by a disturbance in the metabolism of dopamine and/or noradrenaline. These patients are primarily responsive to dual-action (e.g. SNRI) antidepressants. Results of serotonin and catecholamine (dopamine, noradrenaline) depletion studies also suggest that that the dysregulation of serotonin and dopamine/noradrenaline in the CNS is characteristic of different subgroups of depressed patients. In addition to the serotonergic, dopaminergic and noradrenergic systems, many other neurotransmitter systems (e.g. cholinergic, glutamatergic, GABAergic) and other mechanisms (e.g. neuroinfl ammation) have also been proven to play a role in the development of the disorder. Knowledge of the data presented in our publication is important since the simplistic interpretation by Moncrieffetal. of the role of serotonin in the pathogenesis of depression may undermine confidence in SSRIs in many patients. (Neuropsychopharmacol Hung 2022; 24(3): 120-125).

Positive psychology has fully examined the flourishing among healthy people but neglected to understand how "optimal human functioning" can apply to the life experiences of a vulnerable person. Considering methodological issues, this article gives a brief overview on how the conceptualization of mental health and mental disorders affects the consideration of strengths along with the presence of dysfunction with the emergence of positive psychology. First, we summarize the shortcomings of the applicability of clinical positive psychology, focusing especially on Hungarian clinical practice. Second, we discuss the problems with the conceptualization of mental health in positive psychological framework. Third, we propose a model, the Maintainable Positive Mental Health Theory based on capacities and competences. Finally, we conclude with methodological questions and present a research protocol. The key finding of our review is that the opportunity exists for psychiatrists and psychologists to embrace disability as part of human experiences and to show how people with vulnerabilities can be supported to recover. (Neuropsychopharmacol Hung 2022; 24(3): 113-119).

The incidence of borderline personality disorder (BPD) in psychiatric care has shown growing tendencies. Despite its frequency, it is an underdiagnosed disease. Profound knowledge of etiological factors of BPD is essential for the proper diagnosis and treatment. The present study aims to provide a developmental psychopathological analysis of borderline personality disorder, which includes a thorough review of genetic and environmental etiological factors, an introduction to the functionalist approach of evolutionary perspective, and an overview of age specific characteristics of borderline symptoms. Recent research suggests that in addition to neurobiological and psychosocial factors, genetic vulnerability may be responsible for the development of BPD. Psychosocial background includes childhood trauma, maternal mental illness, maladaptive parenting styles and dysfunctional parent-child relationship, all of which are recognized as contributing factors to the development of insecure or disorganized attachment styles in the infant. Regarding the neurobiological background, changes in the hypothalamic-pituitary-adrenal axis, neurotransmission, endogenous opioid system, and neuroplasticity play a prominent role, the development of which is also affected by childhood traumatic events. Brain imaging studies reveal differences in the limbic system (hippocampus, amygdala) and frontal cortex, which are also involved in stress response, cognition, memory function, and emotion regulation. Early developmental processes may also play an important role in the development of the disorder, as depression during pregnancy or increased stress affects the quality of maternal care and may also affect gene expression through epigenetic mechanisms. With respect to the gene-environment interaction, the interaction of the child's impulsive traits and the invalidating family environment can be highlighted, which can lead to disruption of emotion regulation. The persistence of BPD symptoms is supported by the evolutionary approach concerning several aspects. Fear of abandonment can be explained by the anticipation of exclusion and maladaptive attempts to avoid it. Developmental psychopathological analysis contributes to the development of effective prevention and intervention tools through a better understanding of the background of borderline personality disorder. In terms of prognosis, as a result of effective treatments, symptoms can be reduced, so improvement can be achieved in a large proportion of patients.

This review aims to present social anxiety disorder from a developmental psychopathological perspective. Evolutionary theories share the view that social anxiety might be adaptive in specific contexts, and suggest several mechanisms of dysfunction (adaptive trade-off , mismatch, individual differences). The aetiology of social anxiety disorder is characterized by a complex interplay of genetic and environmental factors including gene-environment interactions,correlations and epigenetic mechanisms. Although the main diagnostic criteria of social anxiety disorder are the same throughout the lifespan, developmental characteristics alter its presentation. In children, behavioural symptoms are common. We can view refusal of speech as a specific manifestation of avoidant behaviour related to young age. Therefore, some researchers suggest that selective mutism is an age-specific subtype of the disorder. Even though the majority of researchers agree that behavioural inhibition is an age-specific temperamental risk factor of social anxiety disorder, it might also be viewed as an early, subclinical form of the disorder. In adolescence, as part of the normal development, there is a temporary increase of social anxiety. In this age group, however, there is also an increase in the prevalence of socialanxiety disorder. Adult-onset social anxiety disorder is rare. In adults, social anxiety disorder has to be diff erentiated from avoidant personality disorder. Social anxiety disorder is characterized by strong homotypic continuity, but evidence for a heterotypic continuity is also available,especially with other anxiety disorders and major depression, probably due to shared genetic factors. The developmental psychopathological approach of social anxiety - developmental paths, age-specific characteristics, etc. - may contribute to an early recognition of the disorder and facilitate more effective therapeutic interventions.

Developmental psychopathology is a relatively new discipline which aims to synthetize theories and empirical results of multiple disciplines focusing on development or psychopathology developmental psychology, psychopathology, neuroscience, genetics, personality psychology, volutionary psychopathology, etc.), in order to uncover mechanisms responsible for normative development and its alterations (psychopathology). We aim to give an introduction into three main themes of developmental psychopathology: models of evolutionary psychopathology mechanisms of the complex interplay of genetic and environmental factors contributing normal and abnormal development, and the age-specific characteristics of mental disorders, as well as their continuities and discontinuities across the lifespan. The perspective of developmental psychopathology adds to our deeper understanding of the aetiology and course of mental disorders, and their recognition and treatment.