Neuropsychopharmacologia Hungarica最新文献

Introduction: Yawning is a normal, stereotyped physiological event in humans and animal kingdom. When excessive (>3 per 15 minutes), it is termed as pathological yawning (PY). PY could be due to many causes but more commonly associated with side-effect of drugs, notably involving those used in psychopharmacology. Though there are isolated case reports and case-series, there are no large-scale reports of PY. This work attempted to address this lacuna.

Material and methods: The current work attempted to identify characteristics of PY as collated from adverse drug effect databases of Australia (Database of Adverse Event Notifications), Canada (Canada Vigilance Adverse Reaction Online Database) and the United States of America (FDA Adverse Event Reporting System - FAERS). These databases collect and provide public access to reports of adverse events related to drugs and therapeutic goods. They act as a prime pharmacovigilance tool as well as a first-line resource for healthcare professionals, researchers, and the public to monitor the safety of these products and make informed decisions. In the first week of June 2023, open access, unrestricted adverse effect of drug databases were explored, using the word "YAWNING" as the only search term for the side effect of any drug without any restrictions. The collected details of PY cases with their gender, age, reason for drug use, other concomitant complaints as well as the nature of adverse event(s) and its treatment requirements were assessed. Descriptive statistics were used.

Result: Of the 2655 instances in USA database, 398(15%) had more than 1 suspect drug and in total 578 medications involved. The most commonly involved drugs were apomorphine, sertraline, fluoxetine and paroxetine. In all 341(12.8%) cases reported of YAWN alone or with one another sleep disorder, the most common off ending drug were fluoxetine hydrochloride.

Discussion and conclusion: The neural mechanism and physiology of yawning are explained. This study stresses that a health care professional, particularly mental health professionals and neurologists, should be aware of the importance of PY to deliver the best for the patients under their care. (Neuropsychopharmacol Hung 2023; 25(4): 194-205)

Background: This study examined the relationship between alcohol use, protective behavioral strategies, and self-determination among young adults. Young adults may be particularly prone to risky forms of alcohol use (e.g., heavy episodic drinking) and the resulting negative consequences. Protective behavioral strategies are behaviors used to reduce negative consequences arising from alcohol use. Based on existing literature, autonomous motivation as defined in self-determination theory and the satisfaction of psychological needs may influence these factors and have potential implications for interventions. The main objective of this research is to examine the four-factor structure of the Treatment Self-Regulation Questionnaire in a young adult sample from Hungary, and to explore the association between autonomous motivation related to responsible alcohol use, satisfaction of basic psychological needs, protective behavioral strategies, and the extent of harmful alcohol use.

Methods: The study was based on a cross-sectional questionnaire survey with a total of 272 participants (32.4% male, 67.6% female, average age 23.8 years). The questionnaire package included the Alcohol Use Disorders Identification Test, Protective Behavioral Strategies Scale, Treatment Self-Regulation Questionnaire, and the Basic Psychological Need Satisfaction and Frustration Scale.

Results: Confirmatory factor analysis revealed a modified four-factor structure (amotivation, external regulation, introjected regulation, and autonomous motivation) with the best fi t indices. Autonomous motivation and satisfaction of basic psychological needs showed significant positive, moderate to strong correlations with the frequency of protective strategies use and significant negative, moderate to strong correlations with the extent of harmful alcohol use. There was a significant positive, weak association between autonomous motivation and satisfaction of basic psychological needs. Mediation analysis indicated that protective behavioral strategies partially mediate the relationship between autonomous motivation and harmful alcohol use.

Conclusions: These results are consistent with other literature findings, suggesting that the questionnaire could be applied in future research. Furthermore, both autonomous motivation and satisfaction of basic psychological needs may increase the frequency of protective strategies use and reduce the extent of harmful alcohol use.

Objective: Psychostimulants are widely used pharmacotherapeutic tools in the treatment process of severe or non-responsive childhood attention-deficit/hyperactivity disorder. Despite their efficacy, stimulants can influence the quality and quantity of sleep as a side effect, but this issue remains insufficiently clarified in the existing literature, with partly contradictory findings. The aim of this review is to provide a comprehensive analysis of research results based on polysomnography, shedding light on the current state of knowledge in this area. This insight can be valuable for guiding the design of future research and optimizing therapeutic plans.

Methods: Following the PRISMA guidelines, we systematically reviewed and analyzed studies that assessed the quality of sleep using polysomnography during stimulant treatment. As a result of our search, we identified 331 potential publications, which were independently screened, and a total of 13 relevant articles were analyzed in detail.

Results: Based on the results of the examined studies, there were a total of 5 instances of sleep-facilitating effects reported in the context of stimulant treatments, while 5 studies indicated sleep-inhibiting effects, and in three cases, no effects were observed.

Conclusions: Although it is important to consider the impact of medication on sleep in the treatment of childhood attention-deficit/hyperactivity disorder, further research is required to clarify this issue. This will enable the customization of therapeutic recommendations and plans, aligning with the principles of precision medicine, taking into account the varying research designs and sample sizes.

Frontotemporal dementia is a neurodegenerative disease characterized by atrophy of the frontal and temporal lobes of the brain, and it is believed to primarily develop based on genetic factors. Its initial symptoms can appear relatively early, even between the ages of 40-50, affecting approximately 15-22 individuals out of 100,000 annually. The disease manifests in various forms, categorized into behavioral, aphasic, and motor variants due to its diverse presentations. The behavioral variant, constituting about half of the cases, is the most common type. It involves personality changes, behavioral problems, and cognitive decline, with patients surviving an average of 8.5 years from the onset of symptoms. Currently, there is no curative therapy available, and only symptomatic treatment can be administered to improve the quality of life. In the case we presented, the symptoms of the behavioral variant of frontotemporal dementia appeared atypically, accompanied by perceptual disturbances and a paranoid attitude, further complicating the definitive diagnosis.

Depression is a highly prevalent and debilitating condition, yet we still lack both in-depth knowledge concerning its etiopathology and sufficiently efficacious treatment options. With approximately one third of patients resistant to currently available antidepressants there is a pressing need for a better understanding of depression, identifying subgroups within the highly heterogeneous illness category and to understand the divergent underlying biology of such subtypes, to help develop and personalise treatments. The TRAJECTOME project aims to address such challenges by (1) identifying depression-related multimorbidity subgroups and shared molecular pathways based on temporal disease profiles from healthcare systems and biobank data using machine learning approaches, and by (2) characterising these subgroups from multiple aspects including genetic variants, metabolic processes, lifestyle and environmental factors. Following the identification of multimorbidity trajectories, a disease burden score related to depression and adjusted for multimorbidity was established summarising the current state of the patient to weigh the molecular mechanisms associated with depression. In addition, the role of genetic and environmental factors, and also their interactions were identified for all subgroups. The project also attempted to identify potential metabolomic markers for the early diagnostics of these multimorbidity conditions. Finally, we prioritized molecular drug candidates matching the multimorbidity pathways indicated for the individual subgroups which would potentially offer personalised treatment simultaneously for the observable multimorbid conditions yet minimising polypharmacy and related side effects. The present paper overviews the TRAJECTOME project including its aims, tasks, procedures and accomplishments. (Neuropsychopharmacol Hung 2023; 25(4): 183-193)

Aims: This study sought to synthesize prevalence rates of problematic internet use (PIU) during the COVID-19 pandemic in the general adult (age over 18 years old) population and to investigate its possible moderators.

Methods: A preregistered systematic literature review using the PubMed/MEDLINE, EBSCOhost/PsycINFO, Web of Science, Cochrane Library, GSK Clinical Study Register, and ClinicalTrials.gov databases was conducted. Research was completed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 checklist.

Results: A total of 22 publications were identified, fulfilling inclusion criteria from a total of 595 studies. The analysis revealed that the prevalence of PIU during the COVID-19 pandemic period was 25%, however applying a stringent threshold for the PIU, resulted in a much lower prevalence of 7.9%.

Conclusion: The PIU prevalence rate during the COVID-19 pandemic in the general population was 7.9%. Measuring the prevalence of PIU remains complicated due to the large methodological and cultural diversity that exists, so global prevalence estimates of PIU vary substantially. More methodologically sound research on psychodiagnostic assessment and cultural variances is required. (Neuropsychopharmacol Hung 2023; 25(3): 131-141) Keywords: COVID-19; internet addiction; problematic usage of the internet; prevalence; systematic review, meta-analysis Systematic review registration: PROSPERO registration number: CRD42021284619.

Infertility can be caused by several factors, thus the effective treatment of infertility is a complex and multidisciplinary task. While psychological support is an essential part of infertility treatment, there is growing evidence that the role of psychological factors is much greater, as personality and psychological factors have a significant impact on the development, long-term course, and treatment success of several somatic diseases. Exploring the possible mechanisms through which these psychological factors directly or indirectly contribute to infertility and the success of infertility interventions could help identify high-risk patient groups and tailor treatment to the patient, which may increase the chances of successful pregnancy and live birth in women undergoing assisted reproductive treatment. In this review we aim to summarize current knowledge and research findings on the relationship between psychological factors and infertility treatments, including clinical consequences and implications for future research. Keywords: infertility, assisted reproduction, IVF, adherence, personality, temperaments, affective temperaments, TEMPS-A, stress, depression.

In recent years, the question of how we can grasp the ability to plan future events has come to the forefront in light of the retrieval of personal memories from the past. If episodic memory is responsible for envisioning future events, there appears to be an overlap between autobiographical memory and imagining the future. The aim of this current narrative literature review is to present existing theories and research findings, thereby facilitating the development of an organizational framework necessary for the unified investigation of future thinking. This article introduces the neural network processes underlying episodic future thinking, with particular emphasis on the significance of the hippocampus. It outlines the constructive episodic simulation hypothesis, suggesting that episodic memory and episodic future thinking largely rely on similar neural substrates and assumes that a primary function of the episodic memory system is to flexibly reorganize units of individual, contextual memories to simulate possible future events for the individual. The article presents research results related to memory deficits, as it can be presumed that impairment of autobiographical memory in psychiatric disorders also results in impaired episodic future thinking. Future-oriented thoughts serve various functions, such as decision-making, action planning, and emotional regulation. The article also delves into schema theories, as when generating episodic future thoughts, people often activate their general knowledge about their personal future before a specific event occurs. Future thinking is crucial for well-being, goal attainment, aging, optimism, and understanding clinical conditions. How people think about the future can influence their decisions. The elucidation of emotionally futureoriented thoughts, autobiographical knowledge structures, and life-history schemas plays a crucial role in the construction of episodic future thinking. Understanding the role of memory in simulating future events can be important in comprehending the constructive nature of memory and, in general, the functioning of memory systems in diseases, thereby contributing to the specific selection of treatments for these conditions.

Background/aims: Adult attention-deficit/hyperactivity disorder (ADHD) affects parental functioning which in turn has an impact on the off spring's psychopathology. The aim of this meta-analysis was to assess the relationship between parental ADHD symptoms and parental behaviour, focusing on comparative evaluation of studies using self-report and behavioural observation.

Method: A systematic literature search was conducted in three databases (Web of Science, PubMed, Scopus) resulting 13 studies and 87 effect-sizes (N = 2018) for a metaanalysis. We used random effect model, assessed heterogeneity, and evaluated the possibility of publication bias. We conducted subgroup analyses by method of assessing parental behaviour (self-report/observation), valence of parental behaviour (positive/negative), domain of negative parental behaviour (inconsistent discipline, hostility, corporal punishment), and ADHD symptom clusters (inattention, hyperactivity/impulsivity, combined). Meta-regression analyses were conducted to explore the eff ect of children's mean age, the ratio of mothers in the parent sample, and the ratio of boys and ADHD diagnosis in the children's sample.

Results: The mean effect size of the association of self-reported parental behaviour and ADHD symptoms was small but significant, higher levels of parental ADHD symptoms were related to higher levels of negative and lower levels of positive parental behaviour. The analysis did not suggest a publication bias. The effect was robust across ADHD symptom clusters. Children's mean age, the ratio of mothers in the parent sample, and the ratio of boys and ADHD diagnosis in the children's sample did not have a significant effect. On the other hand, behavioural observation of parental behavior was not related to parental ADHD symptoms.

Conclusion: Our results underlie the importance of methodology of assessing parental behaviour. Multi-method and multi-informant assessment in parenting research is warranted.

The author presents a new psychosomatic stress model. All the elements of the hypothesis are well known but, in this context, are published first. The following are the most critical aspects of the recommended chronic stress model. 1/ Stress contains both sympathetic and parasympathetic elements, but the latter predominate. 2/ The mediator of stress is carbon dioxide, the substance that can turn the psyche into soma. 3/ In humans, chronic stress is mainly social; people cause it to each other. Chronic social stress is created frequently due to deviations in civilisation, education and tolerance. 4/ The freeze response (or freezing behaviour) plays a subordinate role in the animal world; it lasts mainly for a maximum of minutes, while in humans, it dominates and can continue for decades. 5/ The decisive step of freeze is apnea, hypopnea, which occurs due to aversive psychological eff ects. After a more extended existence, mild chronic respiratory acidosis develops and most often appears in the clinical form of obstructive sleep apnea. 6/ Chronic hypercapnia can shape the metabolism into metabolic syndrome. 7/ After that, various cardiovascular and metabolic complications (hypertension, atherosclerosis, type 2 diabetes, depression) may develop - partly due to genetic and lifestyle reasons. (Neuropsychopharmacol Hung 2022; 24(3): 126-133).