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[Interpretation of "Expert recommendations for the prevention of common respiratory viral infections in neonates": problems faced by respiratory syncytial virus infection in neonates]. [对“预防新生儿常见呼吸道病毒感染专家建议”的解读:新生儿呼吸道合胞病毒感染面临的问题]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2409033
Chen Cheng, Ya-Juan Wang, Yuan Shi

Neonates are susceptible to respiratory viral infections, with outbreaks reported in areas with a high population of neonates, such as postpartum care centers and neonatal wards. While specific antiviral drugs are currently available for influenza, symptomatic supportive treatment remains the primary approach for respiratory syncytial virus (RSV), making prevention particularly important. The article closely follows the "Expert recommendations for the prevention of common respiratory viral infections in neonates" and provides an in-depth interpretation of recent breakthroughs in RSV prevention. It discusses the physiological and immunological characteristics of neonates, the disease burden and transmission routes of RSV infection, the main clinical manifestations and long-term effects of RSV infection in neonates, as well as specific preventive measures against RSV and practical recommendations and prevention experiences for RSV from abroad to lay a foundation for RSV prevention and control in neonates in China.

新生儿易受呼吸道病毒感染,据报道,在新生儿人口较多的地区,如产后护理中心和新生儿病房,都有暴发。虽然目前有针对流感的特异性抗病毒药物,但对症支持治疗仍然是治疗呼吸道合胞病毒(RSV)的主要方法,因此预防尤为重要。这篇文章紧跟“预防新生儿常见呼吸道病毒感染的专家建议”,并对最近在RSV预防方面的突破进行了深入的解释。探讨新生儿的生理和免疫学特点、RSV感染的疾病负担和传播途径、新生儿RSV感染的主要临床表现和远期影响,以及国外对RSV的具体预防措施和实用建议和预防经验,为中国新生儿RSV防控奠定基础。
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引用次数: 0
[Berberine ameliorates coronary artery endothelial cell injury in Kawasaki disease through complement and coagulation cascades]. [小檗碱通过补体和凝血级联改善川崎病冠状动脉内皮细胞损伤]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2406075
Jin-Wen Liao, Xin Guo, Bo Liang, Xu-Xia Li, Ming-Guo Xu

Objectives: To explore the role of berberine (BBR) in ameliorating coronary endothelial cell injury in Kawasaki disease (KD) by regulating the complement and coagulation cascade.

Methods: Human coronary artery endothelial cells (HCAEC) were divided into a healthy control group, a KD group, and a BBR treatment group (n=3 for each group). The healthy control group and KD group were supplemented with 15% serum from healthy children and KD patients, respectively, while the BBR treatment group received 15% serum from KD patients followed by the addition of 20 mmol/L BBR. Differential protein expression was analyzed and identified using isobaric tags for relative and absolute quantitation technology and liquid chromatography-tandem mass spectrometry, followed by GO functional enrichment analysis and KEGG signaling pathway enrichment analysis of the differential proteins. Western blot was used to detect differential protein expression.

Results: A total of 518 differential proteins were identified between the KD group and the healthy control group (300 upregulated proteins and 218 downregulated proteins). A total of 422 differential proteins were identified between the BBR treatment group and the KD group (221 upregulated proteins and 201 downregulated proteins). Bioinformatics analysis showed that compared to the healthy control group, the differential proteins in the KD group were enriched in the complement and coagulation cascade and ribosome biogenesis in eukaryotes. Compared to the KD group, the differential proteins in the BBR treatment group were also enriched in the complement and coagulation cascade and ribosome biogenesis in eukaryotes. Western blot results indicated that compared to the healthy control group, the expression of complement C1q subcomponent subunit C (C1QC), kininogen-1 (KNG1), complement C1s subcomponent (C1S), and C4b-binding protein alpha chain (C4BPA) was increased in the KD group (P<0.05). Compared to the KD group, the expression of KNG1, C1S, C1QC, and C4BPA was decreased in the BBR treatment group (P<0.05).

Conclusions: The complement and coagulation cascade may be involved in the regulation of BBR treatment for coronary injury in KD, and C1QC, KNG1, C1S, and C4BPA may serve as biomarkers for this treatment.

目的:探讨小檗碱(BBR)通过调节补体和凝血级联改善川崎病(KD)冠状动脉内皮细胞损伤的作用。方法:将人冠状动脉内皮细胞(HCAEC)分为健康对照组、KD组和BBR治疗组(每组n=3)。健康对照组和KD组分别添加15%的健康儿童血清和KD患者血清,BBR治疗组添加15%的KD患者血清,然后添加20 mmol/L BBR。采用等压标签相对定量和绝对定量技术、液相色谱-串联质谱技术对差异蛋白表达进行分析鉴定,并对差异蛋白进行GO功能富集分析和KEGG信号通路富集分析。Western blot检测差异蛋白表达。结果:KD组与健康对照组之间共鉴定出518个差异蛋白(300个上调蛋白,218个下调蛋白)。在BBR处理组和KD组之间共鉴定出422个差异蛋白(221个上调蛋白和201个下调蛋白)。生物信息学分析表明,与健康对照组相比,KD组的差异蛋白在真核生物的补体、凝血级联和核糖体生物发生中富集。与KD组相比,BBR处理组的差异蛋白在真核生物的补体、凝血级联和核糖体生物发生中也富集。Western blot结果显示,与健康对照组相比,KD组补体C1q亚组分亚单位C (C1QC)、kinino原-1 (KNG1)、补体C1s亚组分(C1s)和c4b结合蛋白α链(C4BPA)的表达增加(ppp)。结论:补体和凝血级联可能参与了KD患者BBR治疗冠状动脉损伤的调控,C1QC、KNG1、C1s和C4BPA可能是该治疗的生物标志物。
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引用次数: 0
[Development of a predictive scoring model for non-response to intravenous immunoglobulin in Kawasaki disease]. [川崎病静脉注射免疫球蛋白无反应的预测评分模型的建立]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2408077
Yi-Xu Huang, Yu Huang, Guang-Huan Pi

Objectives: To explore the predictive factors for non-response to intravenous immunoglobulin (IVIG) in children with Kawasaki disease (KD) and to establish an IVIG non-response prediction scoring model for the Sichuan region.

Methods: A retrospective study was conducted by collecting clinical data from children with KD admitted to four tertiary hospitals in Sichuan Province between 2019 and 2023. Among them, 940 children responded to IVIG, while 74 children did not respond. Multivariate logistic regression analysis was used to identify the predictive factors for non-response to IVIG and to establish a predictive scoring model. The model's effectiveness was assessed using the receiver operating characteristic curve (ROC) and validated with an independent dataset.

Results: Multivariate logistic regression analysis showed that the platelet-to-lymphocyte ratio (PLR), hemoglobin (Hb), serum creatinine, aspartate aminotransferase (AST), and platelet count (PLT) were closely related to non-response to IVIG in children with KD (P<0.05). Based on these indicators, a predictive scoring model was established: PLR > 199, 0.4 points; Hb ≤ 116 g/L, 4 points; AST > 58 U/L, 0.2 points; serum creatinine > 38 µmol/L, 3.9 points; PLT count ≤ 275 × 109/L, 0.3 points. Using this model, children with KD were scored, and a total score greater than 4.3 was considered high risk of non-response to IVIG. The sensitivity of the model in predicting non-response to IVIG was 77.0%, specificity was 65.7%, and the area under the ROC curve was 0.746 (95%CI: 0.688-0.805).

Conclusions: The predictive scoring model based on PLR, Hb, serum creatinine, AST, and PLT demonstrates good predictive performance for non-response to IVIG in children with KD in the Sichuan region and can serve as a reference for clinical decision-making.

目的:探讨川崎病(KD)患儿静脉注射免疫球蛋白(IVIG)无反应的预测因素,建立适用于四川地区的IVIG无反应预测评分模型。方法:收集2019 - 2023年四川省四所三级医院收治的KD患儿临床资料,进行回顾性研究。其中940名儿童对IVIG有反应,74名儿童没有反应。采用多因素logistic回归分析,确定IVIG无反应的预测因素,建立预测评分模型。使用受试者工作特征曲线(ROC)评估模型的有效性,并使用独立数据集进行验证。结果:多因素logistic回归分析显示,血小板/淋巴细胞比(PLR)、血红蛋白(Hb)、血清肌酐、天冬氨酸转氨酶(AST)、血小板计数(PLT)与KD患儿IVIG无应答密切相关(P 199, 0.4分;Hb≤116 g/L, 4分;AST > 58 U/L, 0.2分;血清肌酐> 38µmol/L, 3.9分;PLT计数≤275 × 109/L, 0.3分。使用该模型对KD患儿进行评分,总分大于4.3分被认为是IVIG无反应的高风险。该模型预测IVIG无反应的敏感性为77.0%,特异性为65.7%,ROC曲线下面积为0.746 (95%CI: 0.688-0.805)。结论:基于PLR、Hb、血清肌酐、AST、PLT的预测评分模型对四川地区KD患儿IVIG无应答具有较好的预测效果,可作为临床决策参考。
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引用次数: 0
[Research advances in maturity-onset diabetes of the young]. [青少年成年性糖尿病的研究进展]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2408070
Hui-Yun Geng, Zhi-Hua Wang

Maturity-onset diabetes of the young (MODY) is a special type of diabetes characterized by clinical features including early onset of diabetes (before 30 years of age), autosomal dominant inheritance, impaired glucose-induced insulin secretion, and hyperglycemia. So far, 14 types of MODY have been reported, accounting for about 1%-5% of the patients with diabetes. MODY often presents with an insidious onset, and although 14 subtypes have been identified for MODY, it is frequently misdiagnosed as type 1 or type 2 diabetes due to overlapping clinical features and high costs and limitations of genetic testing. This article reviews the clinical features of MODY subtypes in order to improve the accuracy of the diagnosis and treatment of MODY.

青壮年型糖尿病(Maturity-onset diabetes of the young, MODY)是一种特殊类型的糖尿病,其临床特征包括糖尿病早发(30岁前)、常染色体显性遗传、葡萄糖诱导的胰岛素分泌受损、高血糖等。目前已报道的MODY有14种,约占糖尿病患者的1%-5%。MODY发病隐匿,虽然已鉴定出14种MODY亚型,但由于临床特征重叠、成本高和基因检测的局限性,经常被误诊为1型或2型糖尿病。本文就MODY亚型的临床特点进行综述,以期提高MODY的诊断和治疗的准确性。
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引用次数: 0
[Clinical characteristics and long-term follow-up study of basal ganglia infarction after minor head trauma in infants and young children]. [婴幼儿轻微头部外伤后基底神经节梗死的临床特点及长期随访研究]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2408136
Huan Xu, Chen-Chen Wu, Ji-Hong Tang, Jun Feng, Xiao Xiao, Xiao-Yan Shi, Dao-Qi Mei

Objectives: To investigate the clinical characteristics and prognosis of infants and young children with basal ganglia infarction after minor head trauma (BGIMHT).

Methods: A retrospective analysis was conducted on the clinical data and follow-up results of children aged 28 days to 3 years with BGIMHT who were hospitalized at Children's Hospital of Soochow University from January 2011 to January 2022.

Results: A total of 45 cases of BGIMHT were included, with the most common symptom being limb movement disorders (96%, 43/45), followed by facioplegia (56%, 25/45). Cerebral imaging showed that 72% (31/43) had infarction accompanied by basal ganglia calcification. After conservative treatment, 42 children (93%) showed significant symptom improvement, while 3 children (7%) experienced recurrent strokes. The median follow-up time was 82 months (range: 17-141 months). At the last follow-up, 97% (29/30) had residual basal ganglia softening lesions. Among 29 cases participating in questionnaire follow-up, 66% (19/29) recovered normally, 17% (5/29) showed significant improvement in symptoms, and 17% (5/29) had poor improvement. According to the grading of the Global Burden of Disease Control Projects, only 1 child (3%) had severe sequelae. There were no significant differences in age at onset, gender, or presence of concomitant basal ganglia calcification between children with and without neurological sequelae (P>0.05).

Conclusions: The most common initial symptom of BGIMHT is limb movement disorder, and imaging results indicate that most children have concurrent intracranial calcifications. Most infarct lesions later transform into softening lesions, resulting in a generally good prognosis.

目的:探讨婴幼儿颅脑外伤后基底神经节梗死的临床特点及预后。方法:回顾性分析2011年1月至2022年1月苏州大学儿童医院收治的28天~ 3岁BGIMHT患儿的临床资料及随访结果。结果:共纳入45例BGIMHT,最常见的症状为肢体运动障碍(96%,43/45),其次为面部截瘫(56%,25/45)。脑显像显示72%(31/43)脑梗死伴基底节区钙化。保守治疗后,42例患儿(93%)症状明显改善,3例患儿(7%)卒中复发。中位随访时间82个月(范围17-141个月)。在最后一次随访中,97%(29/30)有残留的基底节区软化病变。参与问卷随访的29例患者中,66%(19/29)恢复正常,17%(5/29)症状明显改善,17%(5/29)症状改善不佳。根据全球疾病控制项目负担的分级,只有1名儿童(3%)有严重的后遗症。有和无神经系统后遗症的儿童在发病年龄、性别或是否存在伴发基底神经节钙化方面无显著差异(P < 0.05)。结论:BGIMHT最常见的首发症状为肢体运动障碍,影像学结果显示多数患儿伴有颅内钙化。大多数梗死灶后来转化为软化灶,预后一般较好。
{"title":"[Clinical characteristics and long-term follow-up study of basal ganglia infarction after minor head trauma in infants and young children].","authors":"Huan Xu, Chen-Chen Wu, Ji-Hong Tang, Jun Feng, Xiao Xiao, Xiao-Yan Shi, Dao-Qi Mei","doi":"10.7499/j.issn.1008-8830.2408136","DOIUrl":"10.7499/j.issn.1008-8830.2408136","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical characteristics and prognosis of infants and young children with basal ganglia infarction after minor head trauma (BGIMHT).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data and follow-up results of children aged 28 days to 3 years with BGIMHT who were hospitalized at Children's Hospital of Soochow University from January 2011 to January 2022.</p><p><strong>Results: </strong>A total of 45 cases of BGIMHT were included, with the most common symptom being limb movement disorders (96%, 43/45), followed by facioplegia (56%, 25/45). Cerebral imaging showed that 72% (31/43) had infarction accompanied by basal ganglia calcification. After conservative treatment, 42 children (93%) showed significant symptom improvement, while 3 children (7%) experienced recurrent strokes. The median follow-up time was 82 months (range: 17-141 months). At the last follow-up, 97% (29/30) had residual basal ganglia softening lesions. Among 29 cases participating in questionnaire follow-up, 66% (19/29) recovered normally, 17% (5/29) showed significant improvement in symptoms, and 17% (5/29) had poor improvement. According to the grading of the Global Burden of Disease Control Projects, only 1 child (3%) had severe sequelae. There were no significant differences in age at onset, gender, or presence of concomitant basal ganglia calcification between children with and without neurological sequelae (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>The most common initial symptom of BGIMHT is limb movement disorder, and imaging results indicate that most children have concurrent intracranial calcifications. Most infarct lesions later transform into softening lesions, resulting in a generally good prognosis.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 1","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)]. 【早产儿贫血诊治临床实践指南(2025)】。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2407094

Anemia of prematurity (AOP) is a multifactorial condition associated with congenital iron deficiency, low erythropoietin levels, a short lifespan of red blood cells, and iatrogenic blood loss. AOP is a common complication in premature infants that can adversely affect growth, development, and long-term neurocognitive outcomes. To standardize the diagnosis and treatment of AOP, the Neonatal Clinical Practice Guidelines Expert Committee and the Neonatal Evidence-Based Medicine Group of the Commission of Neonatal Medicine of the Cross-Strait Medical and Health Exchange Association, along with the Editorial Office of the Chinese Journal of Contemporary Pediatrics, have developed the "Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)", based on the World Health Organization's handbook for guideline development and the formulation/revision principles of Chinese clinical practice guidelines. This guideline addresses eight clinical issues related to AOP, including risk factors, early identification, etiological diagnosis, diagnostic criteria, early prevention, transfusion therapy, strategies to improve prognosis, and post-discharge follow-up. It presents 29 recommendations formed from current evidence and expert consensus, aiming to provide guidance and decision-making support for healthcare professionals in the diagnosis and treatment of AOP.

早产儿贫血(AOP)是一种多因素疾病,与先天性缺铁、低促红细胞生成素水平、红细胞寿命短和医源性失血有关。AOP是早产儿中一种常见的并发症,可以对生长、发育和长期神经认知结果产生不利影响。为规范AOP的诊治,海峡两岸医疗卫生交流协会新生儿医学专业委员会新生儿临床实践指南专家委员会、新生儿循证医学专家组与《中国当代儿科学杂志》编辑部共同制定了《早产儿贫血诊治临床实践指南(2025)》。依据世界卫生组织指南制定手册和中国临床实践指南制定/修订原则。本指南涉及与AOP相关的八个临床问题,包括危险因素、早期识别、病因诊断、诊断标准、早期预防、输血治疗、改善预后的策略和出院后随访。根据现有证据和专家共识提出了29条建议,旨在为医疗保健专业人员在AOP的诊断和治疗方面提供指导和决策支持。
{"title":"[Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)].","authors":"","doi":"10.7499/j.issn.1008-8830.2407094","DOIUrl":"10.7499/j.issn.1008-8830.2407094","url":null,"abstract":"<p><p>Anemia of prematurity (AOP) is a multifactorial condition associated with congenital iron deficiency, low erythropoietin levels, a short lifespan of red blood cells, and iatrogenic blood loss. AOP is a common complication in premature infants that can adversely affect growth, development, and long-term neurocognitive outcomes. To standardize the diagnosis and treatment of AOP, the Neonatal Clinical Practice Guidelines Expert Committee and the Neonatal Evidence-Based Medicine Group of the Commission of Neonatal Medicine of the Cross-Strait Medical and Health Exchange Association, along with the Editorial Office of the <i>Chinese Journal of Contemporary Pediatrics</i>, have developed the \"Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)\", based on the World Health Organization's handbook for guideline development and the formulation/revision principles of Chinese clinical practice guidelines. This guideline addresses eight clinical issues related to AOP, including risk factors, early identification, etiological diagnosis, diagnostic criteria, early prevention, transfusion therapy, strategies to improve prognosis, and post-discharge follow-up. It presents 29 recommendations formed from current evidence and expert consensus, aiming to provide guidance and decision-making support for healthcare professionals in the diagnosis and treatment of AOP.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Explanation and interpretation of blood transfusion provisions for children with hematological diseases in the national health standard "Guideline for pediatric transfusion"]. 【对国家卫生标准《小儿输血指南》中血液病患儿输血规定的说明和解读】。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2410093
Ming-Yi Zhao, Rong Huang, Rong Gui, Qing-Nan He, Ming-Yan Hei, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Ming-Hua Yang

To guide clinical blood transfusion practices for pediatric patients, the National Health Commission has issued the health standard "Guideline for pediatric transfusion" (WS/T 795-2022). Blood transfusion is one of the most commonly used supportive treatments for children with hematological diseases. This guideline provides guidance and recommendations for blood transfusions in children with aplastic anemia, thalassemia, autoimmune hemolytic anemia, glucose-6-phosphate dehydrogenase deficiency, acute leukemia, myelodysplastic syndromes, immune thrombocytopenic purpura, and thrombotic thrombocytopenic purpura. This article presents the evidence and interpretation of the blood transfusion provisions for children with hematological diseases in the "Guideline for pediatric transfusion", aiming to assist in the understanding and implementing the blood transfusion section of this guideline.

为指导儿科患者的临床输血操作,国家卫健委发布了卫生标准《儿科输血指南》(WS/T 795-2022)。输血是儿童血液病最常用的支持性治疗方法之一。本指南为再生障碍性贫血、地中海贫血、自身免疫性溶血性贫血、葡萄糖-6-磷酸脱氢酶缺乏症、急性白血病、骨髓增生异常综合征、免疫性血小板减少性紫癜和血栓性血小板减少性紫癜患儿输血提供指导和建议。本文通过对《儿科输血指南》中血液病患儿输血规定的证据和解读,旨在帮助理解和实施该指南中输血部分。
{"title":"[Explanation and interpretation of blood transfusion provisions for children with hematological diseases in the national health standard \"Guideline for pediatric transfusion\"].","authors":"Ming-Yi Zhao, Rong Huang, Rong Gui, Qing-Nan He, Ming-Yan Hei, Xiao-Fan Zhu, Jun Lu, Xiao-Jun Xu, Tian-Ming Yuan, Rong Zhang, Xu Wang, Jin-Ping Liu, Jing Wang, Zhi-Li Shao, Yong-Jian Guo, Xin-Yin Wu, Jia-Rui Chen, Qi-Rong Chen, Jia Guo, Ming-Hua Yang","doi":"10.7499/j.issn.1008-8830.2410093","DOIUrl":"10.7499/j.issn.1008-8830.2410093","url":null,"abstract":"<p><p>To guide clinical blood transfusion practices for pediatric patients, the National Health Commission has issued the health standard \"Guideline for pediatric transfusion\" (WS/T 795-2022). Blood transfusion is one of the most commonly used supportive treatments for children with hematological diseases. This guideline provides guidance and recommendations for blood transfusions in children with aplastic anemia, thalassemia, autoimmune hemolytic anemia, glucose-6-phosphate dehydrogenase deficiency, acute leukemia, myelodysplastic syndromes, immune thrombocytopenic purpura, and thrombotic thrombocytopenic purpura. This article presents the evidence and interpretation of the blood transfusion provisions for children with hematological diseases in the \"Guideline for pediatric transfusion\", aiming to assist in the understanding and implementing the blood transfusion section of this guideline.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk factors for plastic bronchitis in children with macrolide-unresponsive Mycoplasma pneumoniae pneumonia and establishment of a nomogram model]. [大环内酯无反应肺炎支原体肺炎患儿塑性支气管炎的危险因素及nomogram模型的建立]。
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7499/j.issn.1008-8830.2408073
Xiao-Song Shi, Xiao-Hua He, Jie Chen

Objectives: To investigate the risk factors for plastic bronchitis (PB) in children with macrolide-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) and to establish a nomogram prediction model.

Methods: A retrospective analysis was conducted on 178 children with MUMPP who underwent bronchoscopy from January to December 2023. According to the presence or absence of PB, the children were divided into a PB group (49 children) and a non-PB group (129 children). The predictive factors for the development of PB in children with MUMPP were analyzed, and a nomogram prediction model was established. The model was assessed in terms of discriminatory ability, accuracy, and clinical effectiveness.

Results: The multivariate logistic regression analysis showed that older age and higher levels of lactate dehydrogenase and fibrinogen were closely associated with the development of PB in children with MUMPP (P<0.05). A nomogram model established based on these factors had an area under the receiver operating characteristic curve of 0.733 (95%CI: 0.651-0.816, P<0.001) and showed a good discriminatory ability. The Hosmer-Lemeshow goodness-of-fit test indicated that the predictive model had a good degree of fit (P>0.05), and the decision curve analysis showed that the model had a good clinical application value.

Conclusions: The risk nomogram model established based on age and lactate dehydrogenase and fibrinogen levels has good discriminatory ability, accuracy, and predictive efficacy for predicting the development of PB in children with MUMPP.

目的:探讨大环内酯无反应性肺炎支原体肺炎(MUMPP)患儿塑性支气管炎(PB)的危险因素,并建立模型预测模型。方法:对2023年1 - 12月行支气管镜检查的178例MUMPP患儿进行回顾性分析。根据是否存在PB,将儿童分为PB组(49名)和非PB组(129名)。分析MUMPP患儿PB发展的预测因素,建立nomogram预测模型。评估该模型的区分能力、准确性和临床有效性。结果:多因素logistic回归分析显示,年龄越大、乳酸脱氢酶和纤维蛋白原水平越高与MUMPP患儿PB的发生密切相关(PCI: 0.651-0.816, PP>0.05),决策曲线分析表明该模型具有较好的临床应用价值。结论:基于年龄、乳酸脱氢酶和纤维蛋白原水平建立的风险nomogram模型对预测MUMPP患儿PB的发展具有良好的鉴别能力、准确性和预测效果。
{"title":"[Risk factors for plastic bronchitis in children with macrolide-unresponsive <i>Mycoplasma pneumoniae</i> pneumonia and establishment of a nomogram model].","authors":"Xiao-Song Shi, Xiao-Hua He, Jie Chen","doi":"10.7499/j.issn.1008-8830.2408073","DOIUrl":"10.7499/j.issn.1008-8830.2408073","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the risk factors for plastic bronchitis (PB) in children with macrolide-unresponsive <i>Mycoplasma pneumoniae</i> pneumonia (MUMPP) and to establish a nomogram prediction model.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 178 children with MUMPP who underwent bronchoscopy from January to December 2023. According to the presence or absence of PB, the children were divided into a PB group (49 children) and a non-PB group (129 children). The predictive factors for the development of PB in children with MUMPP were analyzed, and a nomogram prediction model was established. The model was assessed in terms of discriminatory ability, accuracy, and clinical effectiveness.</p><p><strong>Results: </strong>The multivariate logistic regression analysis showed that older age and higher levels of lactate dehydrogenase and fibrinogen were closely associated with the development of PB in children with MUMPP (<i>P</i><0.05). A nomogram model established based on these factors had an area under the receiver operating characteristic curve of 0.733 (95%<i>CI</i>: 0.651-0.816, <i>P</i><0.001) and showed a good discriminatory ability. The Hosmer-Lemeshow goodness-of-fit test indicated that the predictive model had a good degree of fit (<i>P</i>>0.05), and the decision curve analysis showed that the model had a good clinical application value.</p><p><strong>Conclusions: </strong>The risk nomogram model established based on age and lactate dehydrogenase and fibrinogen levels has good discriminatory ability, accuracy, and predictive efficacy for predicting the development of PB in children with MUMPP.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"27 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the application of comprehensive behavioral intervention in tic disorder]. 综合行为干预在抽动障碍中的应用进展
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7499/j.issn.1008-8830.2407171
Sai Fu, Qian Song, Xiang-Jun He, Xiao-Yu Tian

Tic disorder is a neurodevelopmental disorder that occurs in children or adolescents, often attracting the attention of others due to involuntary, repetitive, and non-rhythmic tics, and drug therapy often causes negative emotions in children and their families due to its significant adverse reactions, poor compliance, and tendency of recurrence after drug withdrawal. In recent years, comprehensive behavioral intervention has shown great potential as a safe and effective treatment modality for tic disorders, with few adverse reactions. This article reviews the advances in the application of comprehensive behavioral intervention for tic disorder in China and abroad in the past 5 years, in order to provide a reference for clinical application.

抽动障碍是一种发生于儿童或青少年的神经发育障碍,常因不自主的、重复的、无节奏的抽动而引起他人的注意,药物治疗因其不良反应显著、依从性差、停药后有复发倾向,常引起儿童及其家庭的负面情绪。近年来,综合行为干预作为一种安全有效、不良反应少的抽动障碍治疗方式显示出巨大的潜力。本文综述了近5年来国内外抽动障碍综合行为干预的应用进展,以期为临床应用提供参考。
{"title":"[Advances in the application of comprehensive behavioral intervention in tic disorder].","authors":"Sai Fu, Qian Song, Xiang-Jun He, Xiao-Yu Tian","doi":"10.7499/j.issn.1008-8830.2407171","DOIUrl":"10.7499/j.issn.1008-8830.2407171","url":null,"abstract":"<p><p>Tic disorder is a neurodevelopmental disorder that occurs in children or adolescents, often attracting the attention of others due to involuntary, repetitive, and non-rhythmic tics, and drug therapy often causes negative emotions in children and their families due to its significant adverse reactions, poor compliance, and tendency of recurrence after drug withdrawal. In recent years, comprehensive behavioral intervention has shown great potential as a safe and effective treatment modality for tic disorders, with few adverse reactions. This article reviews the advances in the application of comprehensive behavioral intervention for tic disorder in China and abroad in the past 5 years, in order to provide a reference for clinical application.</p>","PeriodicalId":39792,"journal":{"name":"中国当代儿科杂志","volume":"26 12","pages":"1367-1372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical characteristics and prognosis of children with T-lineage acute lymphoblastic leukemia: a single-center study]. 儿童t系急性淋巴细胞白血病的临床特征和预后:一项单中心研究。
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7499/j.issn.1008-8830.2408039
Xiao-Yan Chen, Jia-Yi Wang, Hua Jiang, Wei-Na Zhang

Objectives: To study the clinical characteristics and prognosis of T-lineage acute lymphoblastic leukemia (T-ALL) and related prognostic factors.

Methods: A retrospective analysis was conducted on the children with T-ALL who were treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia (CCCG-ALL) regimen in Guangzhou Women and Children's Medical Center between April 2015 and December 2022.

Results: A total of 80 children were included, with a median age of 7 years and 3 months and a male/female ratio of 6:1. Among these children, the children with mediastinal mass accounted for 20% (16/80), those with central nervous system leukemia accounted for 4% (3/80), and those with testicular leukemia accounted for 1% (1/69). SIL/TAL1 was the most common fusion gene (22%, 18/80), and NOTCH1 was the most common mutation gene (69%, 37/54). The median follow-up time was 52 months, with a 5-year overall survival (OS) rate of 87.3%±4.0% and a 5-year event-free survival rate of 84.0%±4.3%. The non-central nervous system-1 group had a significantly lower 5-year OS rate than the central nervous system-1 group (66.7%±16.1% vs 90.3%±3.8%; P<0.05), and the group with minimal residual disease (MRD) ≥0.01% on day 46 of induction therapy had a significantly lower 5-year OS rate than the group with MRD <0.01% (68.6%±13.5% vs 94.8%±3.0%; P<0.05).

Conclusions: Children treated with the CCCG-ALL regimen tend to have a good treatment outcome. Non-central nervous system-1 status and MRD ≥0.01% on day 46 of induction therapy are associated with the poor prognosis in these children.

目的:探讨t系急性淋巴细胞白血病(T-ALL)的临床特点、预后及相关影响因素。方法:回顾性分析2015年4月至2022年12月在广州市妇女儿童医疗中心接受中国儿童肿瘤组急性淋巴母细胞白血病(CCCG-ALL)方案治疗的T-ALL患儿。结果:共纳入患儿80例,中位年龄7岁3个月,男女比例为6:1。其中纵隔肿块患儿占20%(16/80),中枢神经系统白血病患儿占4%(3/80),睾丸白血病患儿占1%(1/69)。SIL/TAL1是最常见的融合基因(22%,18/80),NOTCH1是最常见的突变基因(69%,37/54)。中位随访时间为52个月,5年总生存率(OS)为87.3%±4.0%,5年无事件生存率为84.0%±4.3%。非中枢神经系统-1组5年OS率显著低于中枢神经系统-1组(66.7%±16.1% vs 90.3%±3.8%;结论:CCCG-ALL方案患儿治疗效果较好。诱导治疗第46天非中枢神经系统-1状态和MRD≥0.01%与这些患儿预后不良相关。
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中国当代儿科杂志
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