Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.250160
Xiaotan Tan, Qichang Zhou, Hongxia Yuan, Da Hou, Yunfang Zhu, Ruji Yao
Objectives: The diagnostic value of ultrasonographic quantitative indicators of umbilical cord coiling, such as the umbilical coiling index (UCI) and pitch value, in identifying hypercoiling and predicting adverse pregnancy outcomes remains controversial. This study aims to evaluate the predictive value of UCI, pitch value, and the cerebroplacental ratio in pregnancies complicated by umbilical cord hypercoiling.
Methods: Pregnant women with densely coiled umbilical cords identified by routine obstetric ultrasound at Changsha Maternal and Child Health Hospital between November 2022 and November 2024 were enrolled. Complete clinical data, including UCI, pitch value, and cerebroplacental ratio (CPR), were collected. Pregnancy outcome scores were calculated, and newborns were categorized into the normal outcome group (n=177) and adverse outcome group (n=85), with the latter further subdivided into mild (n=51), moderate (n=19), and severe (n=15) subgroups. Differences in baseline data, UCI, pitch value, and incidence of CRP<1 were compared between groups and among subgroups. Correlations between UCI, pitch value, and adverse pregnancy outcomes were analyzed. Receiver operating characteristic (ROC) curve were used to assess the predictive performance of UCI, pitch value, CPR<1, and their combinations.
Results: Compared with the normal outcome group, the adverse outcome group had higher age, parity, parity, incidence of CPR<1, and UCI, while gestational age at delivery and pitch values were lower (all P<0.05). The incidence of obesity, gestational diabetes mellitus, and hypertensive disorders of pregnancy did not differ significantly between the 2 groups (all P>0.05). The normal outcome group showed lower UCI and higher pitch values than all 3 adverse outcome subgroups (all P<0.05), while differences among the 3 adverse subgroups were not significant (all P>0.05). UCI was positively correlated with adverse pregnancy outcomes (rs=0.350, P<0.05), whereas pitch value was negatively correlated (rs=-0.286, P<0.05). ROC curve analysis showed that the area under the curve (AUC) values for predicting adverse outcomes were 0.837 for UCI, 0.886 for pitch value, and 0.610 for CPR<1, with sensitivities of 77.6%, 82.4%, and 27.1% and specificities of 78.5%, 83.6%, and 94.9%, respectively. The combined UCI+CPR<1 and pitch value+CPR<1 models yielded AUCs of 0.841 and 0.886, with sensitivities of 78.8% and 81.2% and specificities of 78.5% and 84.2%, respectively. No significant differences were found between the AUCs of UCI and pitch value (P>0.05), but both outperformed CPR<1 alone (both P<0.001). The combined models showed no significant improvement over UCI or pitch value alone (both P>0.05), though both were superior to CPR<1 alone (both P<0.001).
{"title":"[Predictive value of ultrasound-derived quantitative indicators of umbilical cord hypercoiling and hemodynamic parameters for adverse pregnancy outcomes].","authors":"Xiaotan Tan, Qichang Zhou, Hongxia Yuan, Da Hou, Yunfang Zhu, Ruji Yao","doi":"10.11817/j.issn.1672-7347.2025.250160","DOIUrl":"10.11817/j.issn.1672-7347.2025.250160","url":null,"abstract":"<p><strong>Objectives: </strong>The diagnostic value of ultrasonographic quantitative indicators of umbilical cord coiling, such as the umbilical coiling index (UCI) and pitch value, in identifying hypercoiling and predicting adverse pregnancy outcomes remains controversial. This study aims to evaluate the predictive value of UCI, pitch value, and the cerebroplacental ratio in pregnancies complicated by umbilical cord hypercoiling.</p><p><strong>Methods: </strong>Pregnant women with densely coiled umbilical cords identified by routine obstetric ultrasound at Changsha Maternal and Child Health Hospital between November 2022 and November 2024 were enrolled. Complete clinical data, including UCI, pitch value, and cerebroplacental ratio (CPR), were collected. Pregnancy outcome scores were calculated, and newborns were categorized into the normal outcome group (<i>n</i>=177) and adverse outcome group (<i>n</i>=85), with the latter further subdivided into mild (<i>n</i>=51), moderate (<i>n</i>=19), and severe (<i>n</i>=15) subgroups. Differences in baseline data, UCI, pitch value, and incidence of CRP<1 were compared between groups and among subgroups. Correlations between UCI, pitch value, and adverse pregnancy outcomes were analyzed. Receiver operating characteristic (ROC) curve were used to assess the predictive performance of UCI, pitch value, CPR<1, and their combinations.</p><p><strong>Results: </strong>Compared with the normal outcome group, the adverse outcome group had higher age, parity, parity, incidence of CPR<1, and UCI, while gestational age at delivery and pitch values were lower (all <i>P</i><0.05). The incidence of obesity, gestational diabetes mellitus, and hypertensive disorders of pregnancy did not differ significantly between the 2 groups (all <i>P</i>>0.05). The normal outcome group showed lower UCI and higher pitch values than all 3 adverse outcome subgroups (all <i>P</i><0.05), while differences among the 3 adverse subgroups were not significant (all <i>P</i>>0.05). UCI was positively correlated with adverse pregnancy outcomes (<i>r</i><sub>s</sub>=0.350, <i>P</i><0.05), whereas pitch value was negatively correlated (<i>r</i><sub>s</sub>=-0.286, <i>P</i><0.05). ROC curve analysis showed that the area under the curve (AUC) values for predicting adverse outcomes were 0.837 for UCI, 0.886 for pitch value, and 0.610 for CPR<1, with sensitivities of 77.6%, 82.4%, and 27.1% and specificities of 78.5%, 83.6%, and 94.9%, respectively. The combined UCI+CPR<1 and pitch value+CPR<1 models yielded AUCs of 0.841 and 0.886, with sensitivities of 78.8% and 81.2% and specificities of 78.5% and 84.2%, respectively. No significant differences were found between the AUCs of UCI and pitch value (<i>P</i>>0.05), but both outperformed CPR<1 alone (both <i>P</i><0.001). The combined models showed no significant improvement over UCI or pitch value alone (both <i>P</i>>0.05), though both were superior to CPR<1 alone (both <i>P</i><0.001).</p><p><strong>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 7","pages":"1179-1187"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.240597
Xiaoling Zhu, Lei Yan, Li Tang, Jiangang Wang, Yazhang Guo, Pingting Yang
Objectives: Cardiovascular disease (CVD) poses a major threat to global health. Evaluating atherosclerosis in asymptomatic individuals can help identify those at high risk of CVD. This study aims to establish an individualized nomogram prediction model to estimate the risk of vascular plaque formation in asymptomatic individuals.
Methods: A total of 5 655 participants who underwent CVD screening at the Health Management Center of The Third Xiangya Hospital, Central South University, between January 2022 and June 2024 we retrospectively enrolled. Using simple random sampling, participants were divided into a training set (n=4 524) and a validation set (n=1 131) in an 8꞉2 ratio. Demographic and clinical data were collected and compared between groups. Multivariate logistic regression analysis was used to identify independent factors associated with vascular plaques and to construct a nomogram prediction model. The predictive performance and clinical utility of the model were evaluated using receiver operating characteristic (ROC) curves, the Hosmer-Lemeshow goodness-of-fit test, calibration plots, and decision curve analysis (DCA).
Results: The mean age of participants was 52 years old. There were 3 400 males (60.12%). The overall detection rate of vascular plaque in the screening population was 49.87% (2 820/5 655). No statistically significant differences were observed in clinical indicators between the training and validation sets (all P>0.05). Multivariate Logistic regression analysis identified age, systolic blood pressure, high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a), male sex, smoking history, hypertension history, and diabetes history as independent risk factors for vascular plaque in asymptomatic individuals (all P<0.05). The area under the curve (AUC) of the nomogram model for predicting vascular plaque risk were 0.778 (95% CI 0.765 to 0.791, P<0.001) in the training set and 0.760 (95% CI 0.732 to 0.787, P<0.001) in the validation set. The Hosmer-Lemeshow goodness-of-fit test indicated good model calibration (training set: P=0.628; validation set: P=0.561). The calibration curve plotted using the Bootstrap method demonstrated good agreement between predicted probabilities and actual probabilities. DCA showed that the nomogram provided a clinical net benefit for predicting vascular plaque risk when the threshold probability ranged from 0.02 to 0.99.
Conclusions: The nomogram prediction model for vascular plaque risk, constructed using readily available and cost-effective physical examination indicators, exhibited good predictive performance. This model can assist in the early identification and intervention of asymptomatic individuals at high risk for cardiovascular disease.
{"title":"[Nomogram prediction model for factors associated with vascular plaques in a physical examination population].","authors":"Xiaoling Zhu, Lei Yan, Li Tang, Jiangang Wang, Yazhang Guo, Pingting Yang","doi":"10.11817/j.issn.1672-7347.2025.240597","DOIUrl":"10.11817/j.issn.1672-7347.2025.240597","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular disease (CVD) poses a major threat to global health. Evaluating atherosclerosis in asymptomatic individuals can help identify those at high risk of CVD. This study aims to establish an individualized nomogram prediction model to estimate the risk of vascular plaque formation in asymptomatic individuals.</p><p><strong>Methods: </strong>A total of 5 655 participants who underwent CVD screening at the Health Management Center of The Third Xiangya Hospital, Central South University, between January 2022 and June 2024 we retrospectively enrolled. Using simple random sampling, participants were divided into a training set (<i>n</i>=4 524) and a validation set (<i>n</i>=1 131) in an 8꞉2 ratio. Demographic and clinical data were collected and compared between groups. Multivariate logistic regression analysis was used to identify independent factors associated with vascular plaques and to construct a nomogram prediction model. The predictive performance and clinical utility of the model were evaluated using receiver operating characteristic (ROC) curves, the Hosmer-Lemeshow goodness-of-fit test, calibration plots, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The mean age of participants was 52 years old. There were 3 400 males (60.12%). The overall detection rate of vascular plaque in the screening population was 49.87% (2 820/5 655). No statistically significant differences were observed in clinical indicators between the training and validation sets (all <i>P</i>>0.05). Multivariate Logistic regression analysis identified age, systolic blood pressure, high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a), male sex, smoking history, hypertension history, and diabetes history as independent risk factors for vascular plaque in asymptomatic individuals (all <i>P</i><0.05). The area under the curve (AUC) of the nomogram model for predicting vascular plaque risk were 0.778 (95% <i>CI</i> 0.765 to 0.791, <i>P</i><0.001) in the training set and 0.760 (95% <i>CI</i> 0.732 to 0.787, <i>P</i><0.001) in the validation set. The Hosmer-Lemeshow goodness-of-fit test indicated good model calibration (training set: <i>P</i>=0.628; validation set: <i>P</i>=0.561). The calibration curve plotted using the Bootstrap method demonstrated good agreement between predicted probabilities and actual probabilities. DCA showed that the nomogram provided a clinical net benefit for predicting vascular plaque risk when the threshold probability ranged from 0.02 to 0.99.</p><p><strong>Conclusions: </strong>The nomogram prediction model for vascular plaque risk, constructed using readily available and cost-effective physical examination indicators, exhibited good predictive performance. This model can assist in the early identification and intervention of asymptomatic individuals at high risk for cardiovascular disease.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 7","pages":"1167-1178"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.250251
Jiao Li, Bowen Xiu, Qiangli Dong
Objectives: Parenting styles and psychological resilience are closely associated with suicidal tendencies among adolescents with depression. This study aims to examine the influence of parenting styles on suicidal ideation and suicidal risk in depressed adolescents and to analyze the mediating role of psychological resilience.
Methods: Depressed adolescents who attended the Department of Mental Health at the Second Hospital of Lanzhou University from March 2023 to August 2024 were enrolled. The Connor-Davidson Resilience Scale (CD-RISC), the Short Egna Minnen av Barndoms Uppfostran (S-EMBU), and the Beck Scale for Suicide Ideation (BSI) were used to assess psychological resilience, parenting styles, and suicidal tendencies. Mediating effects were tested using Stata 17.
Results: A total of 131 adolescents with depression were included, with a mean age of (15±2) years; 82 participants (62.6%) were female. Correlation analyses showed that psychological resilience was significantly negatively correlated with parental overprotection and suicidal risk (r=-0.210 and r=-0.233, respectively; both P<0.01). Parental emotional warmth was significantly negatively correlated with suicidal ideation and suicidal risk (r=-0.141 and r=-0.214, respectively; both P<0.05). Parental overprotection was significantly positively correlated with suicidal ideation (r=0.200, P<0.01). Mediation analysis showed that psychological resilience significantly mediated the relationship between parental overprotection and suicidal risk, accounting for 28.5% of the total effect (P<0.05); however, the mediation effect on suicidal ideation was not statistically significant(P>0.05). Bootstrap analysis further confirmed that this indirect effect was nonsignificant. Parental emotional warmth demonstrated significant mediating effects through psychological resilience on both suicidal ideation and suicidal risk, accounting for 16.7% and 10.5% of the total effects, respectively (both P<0.05). Although the direct effects of parental rejection on suicidal ideation and suicidal risk were not significant(P>0.05), its indirect effects through psychological resilience on both outcomes were significant (accounting for 25.0% and 22.2% of the total effects, respectively; both P<0.05).
Conclusions: Parenting styles exert substantial influence on suicidal tendencies among adolescents with depression, and psychological resilience plays a mediating role in these associations. Reducing parental overprotection and rejection while enhancing emotional warmth may help strengthen adolescents' psychological resilience, thereby lowering their suicide risk.
目的：父母教养方式和心理弹性与抑郁症青少年自杀倾向密切相关。本研究旨在探讨父母教养方式对抑郁青少年自杀意念和自杀风险的影响，并分析心理弹性的中介作用。方法：选取2023年3月至2024年8月在兰州大学第二医院精神卫生科就诊的抑郁青少年为研究对象。采用康诺-戴维森心理弹性量表（CD-RISC）、Short Egna Minnen av Barndoms upppfostran量表（S-EMBU）和贝克自杀意念量表（BSI）评估心理弹性、父母教养方式和自杀倾向。采用Stata 17对中介效应进行检验。结果：共纳入131例青少年抑郁症患者，平均年龄（15±2）岁；82名参与者（62.6%）为女性。相关分析显示，心理弹性与父母过度保护、自杀风险呈显著负相关（r=-0.210、r=-0.233, Pr=-0.141、r=-0.214, Pr=0.200， PPP>0.05）。Bootstrap分析进一步证实了这种间接效应不显著。父母情感温暖通过心理弹性对自杀意念和自杀风险均有显著的中介作用，分别占总效应的16.7%和10.5% (p < 0.05)；父母情感温暖通过心理弹性对自杀意念和自杀风险均有显著的间接影响（分别占总效应的25.0%和22.2%）；结论：父母教养方式对抑郁症青少年自杀倾向有显著影响，心理弹性在其中起中介作用。减少父母的过度保护和排斥，增强情感温暖，有助于增强青少年的心理弹性，从而降低其自杀风险。
{"title":"[Impact of parenting styles on suicidal tendencies in adolescents with depression: Mediating role of psychological resilience].","authors":"Jiao Li, Bowen Xiu, Qiangli Dong","doi":"10.11817/j.issn.1672-7347.2025.250251","DOIUrl":"10.11817/j.issn.1672-7347.2025.250251","url":null,"abstract":"<p><strong>Objectives: </strong>Parenting styles and psychological resilience are closely associated with suicidal tendencies among adolescents with depression. This study aims to examine the influence of parenting styles on suicidal ideation and suicidal risk in depressed adolescents and to analyze the mediating role of psychological resilience.</p><p><strong>Methods: </strong>Depressed adolescents who attended the Department of Mental Health at the Second Hospital of Lanzhou University from March 2023 to August 2024 were enrolled. The Connor-Davidson Resilience Scale (CD-RISC), the Short Egna Minnen av Barndoms Uppfostran (S-EMBU), and the Beck Scale for Suicide Ideation (BSI) were used to assess psychological resilience, parenting styles, and suicidal tendencies. Mediating effects were tested using Stata 17.</p><p><strong>Results: </strong>A total of 131 adolescents with depression were included, with a mean age of (15±2) years; 82 participants (62.6%) were female. Correlation analyses showed that psychological resilience was significantly negatively correlated with parental overprotection and suicidal risk (<i>r</i>=-0.210 and <i>r</i>=-0.233, respectively; both <i>P</i><0.01). Parental emotional warmth was significantly negatively correlated with suicidal ideation and suicidal risk (<i>r</i>=-0.141 and <i>r</i>=-0.214, respectively; both <i>P</i><0.05). Parental overprotection was significantly positively correlated with suicidal ideation (<i>r</i>=0.200, <i>P</i><0.01). Mediation analysis showed that psychological resilience significantly mediated the relationship between parental overprotection and suicidal risk, accounting for 28.5% of the total effect (<i>P</i><0.05); however, the mediation effect on suicidal ideation was not statistically significant(<i>P</i>>0.05). Bootstrap analysis further confirmed that this indirect effect was nonsignificant. Parental emotional warmth demonstrated significant mediating effects through psychological resilience on both suicidal ideation and suicidal risk, accounting for 16.7% and 10.5% of the total effects, respectively (both <i>P</i><0.05). Although the direct effects of parental rejection on suicidal ideation and suicidal risk were not significant(<i>P</i>>0.05), its indirect effects through psychological resilience on both outcomes were significant (accounting for 25.0% and 22.2% of the total effects, respectively; both <i>P</i><0.05).</p><p><strong>Conclusions: </strong>Parenting styles exert substantial influence on suicidal tendencies among adolescents with depression, and psychological resilience plays a mediating role in these associations. Reducing parental overprotection and rejection while enhancing emotional warmth may help strengthen adolescents' psychological resilience, thereby lowering their suicide risk.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1515-1522"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Objectives: </strong>Carotid atherosclerosis (CAS) plaques are independent risk factors for stroke, and chronic vascular inflammation is involved in their pathogenesis. This study aims to explore the association between the systemic immune-inflammation index (SII) and CAS, analyze sex-specific differences in this association, and provide evidence for the early prevention and control of atherosclerosis.</p><p><strong>Methods: </strong>This single-center cross-sectional study included adults who underwent health examinations and completed carotid ultrasound assessments at Xiangya Hospital of Central South University between January and December 2023, among whom those with CAS were classified as a CAS group, and those without CAS were classified as a normal control group. Demographic characteristics, anthropometric measurements, and laboratory data were collected. Participants were categorized into Quartile 1 to 4 based on SII . Four binary logistic regression models were constructed to progressively adjust for confounders and evaluate the association between SII and CAS, with further stratification by sex. Mediation analyses stratified by sex. Mediation analyses stratified by sex were performed using the Bootstrap method (5 000 resamplings), with white blood cell and monocyte counts as mediators. Sensitivity analyses were conducted to verify robustness.</p><p><strong>Results: </strong>A total of 19 788 participants were included, of whom 7 567 (38.24%) had CAS. Compared with controls, individuals with CAS had significantly higher proportions of males, age, waist circumference, systolic and diastolic blood pressure, fasting glucose, and white blood cell count (all <i>P</i><0.001), and significantly lower high-density lipoprotein cholesterol levels (<i>P</i><0.001). Logistic regression revealed notable sex heterogeneity. After adjusting for age and sex (Model 2), higher SII (Quartile 4) was significantly associated with increased CAS risk [odds ratio (<i>OR</i>)=1.26, 95% confidence interval (<i>CI</i>) 1.14 to 1.39, <i>P</i><0.01]. This association persisted after further adjustment for metabolic risk factors (Model 3; <i>OR</i>=1.18, 95% <i>CI</i> 1.07 to 1.31, <i>P</i><0.01). However, after additional adjustment for inflammatory markers such as C-reactive protein, white blood cell, and monocyte counts (Model 4), the association was substantially attenuated and became non-significant in the overall population and in men (<i>P</i>>0.05). Notably, among women, SII remained significantly associated with CAS across all models in both Quartile 2 (<i>OR</i>=1.19, 95% <i>CI</i> 1.02 to 1.39) and Quartile 4 (<i>OR</i>=1.20, 95% <i>CI</i> 1.01 to 1.43) groups (all <i>P</i><0.05). Mediation analysis showed that in the overall population, white blood cell count exerted a complete mediating effect (indirect effect <i>β</i>=0.03, 95% <i>CI</i> 0.01 to 0.05, <i>P</i><0.01; accounting for 46.3% of the total effect), while monocyte count partially media
目的：颈动脉粥样硬化（CAS）斑块是卒中的独立危险因素，慢性血管炎症参与其发病机制。本研究旨在探讨全身免疫炎症指数（systemic immune-inflammation index， SII）与CAS之间的关系，并分析这种关系的性别差异，为动脉粥样硬化的早期防治提供依据。方法：本研究为单中心横断面研究，纳入于2023年1 - 12月在中南大学湘雅医院进行健康检查并完成颈动脉超声评估的成年人，其中有CAS者为CAS组，无CAS者为正常对照组。收集了人口统计学特征、人体测量值和实验室数据。根据SII将参与者分为四分位数1至四分位数4。构建了四个二元逻辑回归模型，逐步调整混杂因素，评估SII和CAS之间的关联，并进一步按性别分层。按性别分层的中介分析。使用Bootstrap方法（5 000次重新采样）进行按性别分层的中介分析，白细胞和单核细胞计数作为中介。进行敏感性分析以验证稳健性。结果：共纳入受试者19 788例，其中7 567例（38.24%）发生CAS。与对照组相比，CAS患者的男性比例、年龄、腰围、收缩压和舒张压、空腹血糖和白细胞计数明显高于对照组（所有PPOR）=1.26, 95%可信区间（CI） 1.14 ~ 1.39， POR=1.18, 95% CI 1.07 ~ 1.31, PP < 0.05)。值得注意的是，在女性中，SII在所有模型中仍然与CAS显著相关，在四分位数2 （OR=1.19, 95% CI 1.02至1.39）和四分位数4 （OR=1.20, 95% CI 1.01至1.43）组（所有Pβ=0.03, 95% CI 0.01至0.05,Pβ=0.01, 95% CI 0至0.02,Pβ=0.04, 95% CI 0.02至0.06,Pβ=0.01, 95% CI 0至0.02,Pβ=0, 95% CI 0至0，P>0.05）和白细胞计数（β=0.01, 95% CI 0至0.02，P>0.05）均无统计学意义。在调整了所有混杂因素后，SII对CAS的直接影响在所有病例中仍然具有统计学意义（所有p）。结论：SII与CAS之间存在显著的性别特异性异质性。高SII是女性CAS的独立相关因素，主要由直接影响驱动，而不是由白细胞或单核细胞计数介导。在男性中，SII主要通过白细胞的完全介导和单核细胞的部分介导影响CAS。这些发现提示了SII在CAS风险评估中的不同性别价值，并为支持性别靶向筛查和干预策略提供了证据。
{"title":"[Correlation between the systemic immune<b>-</b>inflammation index and carotid atherosclerosis: A cross<b>-</b>sectional study based on a health examination population].","authors":"Ruiqi Liu, Qiongmei Fu, Wei Zhou, Shaohui Liu, Zhenghua He, Wenbin Tang, Jian Xia, Chang Zeng","doi":"10.11817/j.issn.1672-7347.2025.250375","DOIUrl":"10.11817/j.issn.1672-7347.2025.250375","url":null,"abstract":"<p><strong>Objectives: </strong>Carotid atherosclerosis (CAS) plaques are independent risk factors for stroke, and chronic vascular inflammation is involved in their pathogenesis. This study aims to explore the association between the systemic immune-inflammation index (SII) and CAS, analyze sex-specific differences in this association, and provide evidence for the early prevention and control of atherosclerosis.</p><p><strong>Methods: </strong>This single-center cross-sectional study included adults who underwent health examinations and completed carotid ultrasound assessments at Xiangya Hospital of Central South University between January and December 2023, among whom those with CAS were classified as a CAS group, and those without CAS were classified as a normal control group. Demographic characteristics, anthropometric measurements, and laboratory data were collected. Participants were categorized into Quartile 1 to 4 based on SII . Four binary logistic regression models were constructed to progressively adjust for confounders and evaluate the association between SII and CAS, with further stratification by sex. Mediation analyses stratified by sex. Mediation analyses stratified by sex were performed using the Bootstrap method (5 000 resamplings), with white blood cell and monocyte counts as mediators. Sensitivity analyses were conducted to verify robustness.</p><p><strong>Results: </strong>A total of 19 788 participants were included, of whom 7 567 (38.24%) had CAS. Compared with controls, individuals with CAS had significantly higher proportions of males, age, waist circumference, systolic and diastolic blood pressure, fasting glucose, and white blood cell count (all <i>P</i><0.001), and significantly lower high-density lipoprotein cholesterol levels (<i>P</i><0.001). Logistic regression revealed notable sex heterogeneity. After adjusting for age and sex (Model 2), higher SII (Quartile 4) was significantly associated with increased CAS risk [odds ratio (<i>OR</i>)=1.26, 95% confidence interval (<i>CI</i>) 1.14 to 1.39, <i>P</i><0.01]. This association persisted after further adjustment for metabolic risk factors (Model 3; <i>OR</i>=1.18, 95% <i>CI</i> 1.07 to 1.31, <i>P</i><0.01). However, after additional adjustment for inflammatory markers such as C-reactive protein, white blood cell, and monocyte counts (Model 4), the association was substantially attenuated and became non-significant in the overall population and in men (<i>P</i>>0.05). Notably, among women, SII remained significantly associated with CAS across all models in both Quartile 2 (<i>OR</i>=1.19, 95% <i>CI</i> 1.02 to 1.39) and Quartile 4 (<i>OR</i>=1.20, 95% <i>CI</i> 1.01 to 1.43) groups (all <i>P</i><0.05). Mediation analysis showed that in the overall population, white blood cell count exerted a complete mediating effect (indirect effect <i>β</i>=0.03, 95% <i>CI</i> 0.01 to 0.05, <i>P</i><0.01; accounting for 46.3% of the total effect), while monocyte count partially media","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1602-1610"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.250392
Xuan Zhao, Qirui Yin, Wei Zhao, Jun Yang, Jie Yang, Guowei Wu, Xuan Ouyang, Zhening Liu, Shuixia Guo, Haojuan Tao
<p><strong>Objectives: </strong>Major depressive disorder (MDD) is a common affective disorder with complex etiologies and largely unclear pathophysiological mechanisms. The nucleus accumbens (NAc) plays a central role in reward processing, motivational regulation, and emotional integration. Neuroimaging studies suggest that structural and functional abnormalities of the NAc are key contributors to the pathogenesis of MDD. However, the alterations in structure-function coupling (SFC) of the NAc in MDD remain poorly understood. This study aims to systematically investigate abnormal functional connectivity (FC) and SFC of the NAc in patients with MDD by integrating functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) techniques.</p><p><strong>Methods: </strong>A case-control design was adopted. Patients who met diagnostic criteria for a current depressive episode of MDD and had a 17-item Hamilton Rating Scale for Depression (HAMD-17) total score ≥17 were enrolled as the MDD group, while age-, sex-, and education-matched healthy controls (HCs) were included as the HC group. All participants underwent high-resolution T<sub>1</sub>-weighted structural imaging, resting-state fMRI, and DTI scanning using a 3.0T MR system. fMRI data preprocessing was performed using SPM12 (Statistical Parametric Mapping 12) and DPARSF (Data Processing Assistant for Resting-State fMRI), while DTI preprocessing was conducted using FSL (FMRIB Software Library). Based on the Brainnetome Atlas, the cerebral cortex was parcellated into 246 regions. FC values between bilateral NAc and the whole brain and the strength of structural connectivity (sSC) derived from probabilistic tractography were calculated. SFC values of bilateral NAc were computed using region-wise Spearman correlations between sSC and FC (ρ). A multiple linear regression model was constructed using FC as the dependent variable and age, gender, years of education, and head motion parameters as covariates, and corrected FC values were extracted from the regression residuals. Group differences in corrected FC values were assessed using independent-sample <i>t</i>-tests with false discovery rate (FDR) correction at a significance level of <i>P</i><0.1. Analysis of covariance was used to compare SFC values between groups, controlling for age, gender, and years of education (a significance level of <i>P</i><0.05). FC values showing significant intergroup differences and SFC values of bilateral NAc were correlated with HAMD-17 total scores using Spearman correlation analysis.</p><p><strong>Results: </strong>There were no significant differences between the MDD and the HC groups in gender (<i>χ</i><sup>2</sup>=0.792, <i>P</i>=0.373), age (<i>t</i>=-0.930, <i>P</i>=0.292), or years of education (<i>t</i>=0.003, <i>P</i>=0.059). Compared with HCs, patients with MDD exhibited significantly increased FC in the following connections: BG.L.3 (left NAc)-IPL.R.4 (right inferior parietal lobule), BG.R
{"title":"[Abnormal functional connectivity and structure-function coupling of the nucleus accumbens in patients with major depressive disorder].","authors":"Xuan Zhao, Qirui Yin, Wei Zhao, Jun Yang, Jie Yang, Guowei Wu, Xuan Ouyang, Zhening Liu, Shuixia Guo, Haojuan Tao","doi":"10.11817/j.issn.1672-7347.2025.250392","DOIUrl":"10.11817/j.issn.1672-7347.2025.250392","url":null,"abstract":"<p><strong>Objectives: </strong>Major depressive disorder (MDD) is a common affective disorder with complex etiologies and largely unclear pathophysiological mechanisms. The nucleus accumbens (NAc) plays a central role in reward processing, motivational regulation, and emotional integration. Neuroimaging studies suggest that structural and functional abnormalities of the NAc are key contributors to the pathogenesis of MDD. However, the alterations in structure-function coupling (SFC) of the NAc in MDD remain poorly understood. This study aims to systematically investigate abnormal functional connectivity (FC) and SFC of the NAc in patients with MDD by integrating functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) techniques.</p><p><strong>Methods: </strong>A case-control design was adopted. Patients who met diagnostic criteria for a current depressive episode of MDD and had a 17-item Hamilton Rating Scale for Depression (HAMD-17) total score ≥17 were enrolled as the MDD group, while age-, sex-, and education-matched healthy controls (HCs) were included as the HC group. All participants underwent high-resolution T<sub>1</sub>-weighted structural imaging, resting-state fMRI, and DTI scanning using a 3.0T MR system. fMRI data preprocessing was performed using SPM12 (Statistical Parametric Mapping 12) and DPARSF (Data Processing Assistant for Resting-State fMRI), while DTI preprocessing was conducted using FSL (FMRIB Software Library). Based on the Brainnetome Atlas, the cerebral cortex was parcellated into 246 regions. FC values between bilateral NAc and the whole brain and the strength of structural connectivity (sSC) derived from probabilistic tractography were calculated. SFC values of bilateral NAc were computed using region-wise Spearman correlations between sSC and FC (ρ). A multiple linear regression model was constructed using FC as the dependent variable and age, gender, years of education, and head motion parameters as covariates, and corrected FC values were extracted from the regression residuals. Group differences in corrected FC values were assessed using independent-sample <i>t</i>-tests with false discovery rate (FDR) correction at a significance level of <i>P</i><0.1. Analysis of covariance was used to compare SFC values between groups, controlling for age, gender, and years of education (a significance level of <i>P</i><0.05). FC values showing significant intergroup differences and SFC values of bilateral NAc were correlated with HAMD-17 total scores using Spearman correlation analysis.</p><p><strong>Results: </strong>There were no significant differences between the MDD and the HC groups in gender (<i>χ</i><sup>2</sup>=0.792, <i>P</i>=0.373), age (<i>t</i>=-0.930, <i>P</i>=0.292), or years of education (<i>t</i>=0.003, <i>P</i>=0.059). Compared with HCs, patients with MDD exhibited significantly increased FC in the following connections: BG.L.3 (left NAc)-IPL.R.4 (right inferior parietal lobule), BG.R","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1579-1589"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.250274
Yi Tang, Laiquan Zou, Xuanxuan Chen, Chao Yan
Depressive disorder is a highly prevalent psychiatric condition that imposes substantial psychological burden on patients and their families, as well as significant economic costs to society. A close relationship exists between depressive disorders and abnormalities in olfactory function, and depressive disorders are frequently accompanied by marked impairments in social functioning. Patients exhibit dysfunction across multiple dimensions of olfactory processing, including olfactory sensitivity, identification, discrimination, and memory, and these abnormalities are influenced by symptom severity and stage of illness. Individuals with depressive disorder show reduced olfactory bulb volume, structural and functional abnormalities in the olfactory cortex, and altered structural and functional connectivity in emotion-related brain regions, such as the amygdala. These neural alterations are associated not only with olfactory dysfunction but also closely with depressive symptoms, providing a neurobiological basis for understanding the emotional and social deficits accompanying depressive disorders. Olfactory dysfunction associated with depressive disorders is characterized by reduced olfactory sensitivity and impaired odor identification, often accompanied by social withdrawal and other forms of diminished social functioning. Reduced olfactory bulb volume, abnormalities in the structure and functional connectivity of emotion-related regions such as the amygdala, along with neuroendocrine dysregulation and heightened inflammatory responses, may together constitute the key mechanisms linking olfactory impairment and depressive symptoms. Interventions targeting the olfactory pathway, such as olfactory training and inhalation-based aromatherapy, have been shown to improve olfactory function and alleviate depressive symptoms to some extent. This mechanistic framework provides important theoretical support and research directions for early identification, diagnosis, and olfactory pathway-targeted intervention strategies for depressive disorders.
{"title":"[Depressive disorders and olfactory dysfunction].","authors":"Yi Tang, Laiquan Zou, Xuanxuan Chen, Chao Yan","doi":"10.11817/j.issn.1672-7347.2025.250274","DOIUrl":"10.11817/j.issn.1672-7347.2025.250274","url":null,"abstract":"<p><p>Depressive disorder is a highly prevalent psychiatric condition that imposes substantial psychological burden on patients and their families, as well as significant economic costs to society. A close relationship exists between depressive disorders and abnormalities in olfactory function, and depressive disorders are frequently accompanied by marked impairments in social functioning. Patients exhibit dysfunction across multiple dimensions of olfactory processing, including olfactory sensitivity, identification, discrimination, and memory, and these abnormalities are influenced by symptom severity and stage of illness. Individuals with depressive disorder show reduced olfactory bulb volume, structural and functional abnormalities in the olfactory cortex, and altered structural and functional connectivity in emotion-related brain regions, such as the amygdala. These neural alterations are associated not only with olfactory dysfunction but also closely with depressive symptoms, providing a neurobiological basis for understanding the emotional and social deficits accompanying depressive disorders. Olfactory dysfunction associated with depressive disorders is characterized by reduced olfactory sensitivity and impaired odor identification, often accompanied by social withdrawal and other forms of diminished social functioning. Reduced olfactory bulb volume, abnormalities in the structure and functional connectivity of emotion-related regions such as the amygdala, along with neuroendocrine dysregulation and heightened inflammatory responses, may together constitute the key mechanisms linking olfactory impairment and depressive symptoms. Interventions targeting the olfactory pathway, such as olfactory training and inhalation-based aromatherapy, have been shown to improve olfactory function and alleviate depressive symptoms to some extent. This mechanistic framework provides important theoretical support and research directions for early identification, diagnosis, and olfactory pathway-targeted intervention strategies for depressive disorders.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1674-1681"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Public health and social measures are essential tools for countries to control epidemic transmission but may also disrupt normal socioeconomic activities. This study aims to analyze differences in public health and social measures policy stringency, temporal trends, and their association with corona virus disease 2019 (COVID-19) control outcomes in 118 countries from January 2020 to September 2022, providing evidence to support the formulation of scientifically grounded public health and social measures policies.
Methods: Boxplots were used to describe the distribution of overall and individual public health and social measures policy stringency scores across 118 countries during the pandemic. Linear and nonlinear models were fitted to examine temporal trends in public health and social measures policy stringency. A two-way fixed-effects model was applied to analyze the association between public health and social measures policy stringency and the effective reproduction number of COVID-19.
Results: The overall public health and social measures stringency scores across the 188 countries ranged from 7.78 to 69.75. Among these countries, temporal trend models for public health and social measures stringency were statistically significant in 108 countries (all third-order polynomial models), with coefficients of determination exceeding 0.25. Overall public health and social measures stringency increased over time in 59 countries but decreased in 49 countries. After adjusting for covariates, country-level fixed effects, and time fixed effects, the overall public health and social measures policy stringency score was negatively associated with effective reproduction number (β'=-0.076, P<0.05). Five individual public health and social measures components, school closures, workplace closures, gathering restrictions, domestic movement restrictions, and mask-wearing policies, were each negatively associated with the effective reproduction number (β'=-0.020, β'=-0.046, β'=-0.032, β'=-0.011, and β'=-0.030, respectively; all P<0.05). In contrast, international travel restrictions were positively associated with the effective reproduction number (β'=0.053, P<0.05).
Conclusions: During the COVID-19 pandemic, the average intensity of public health and social measures implementation varied widely across 118 countries. School closures, workplace closures, gathering restrictions, domestic movement restrictions, and mask-wearing measures effectively curbed COVID-19 transmission, whereas the effectiveness of international travel restrictions diminished over time.
{"title":"[Association of public health and social measures with the effectiveness of COVID-19 epidemic control].","authors":"Huiying Zong, Donghe Li, Yinhuang Dai, Jingtao Zhou, Hao Huang, Guoqing Hu","doi":"10.11817/j.issn.1672-7347.2025.250007","DOIUrl":"10.11817/j.issn.1672-7347.2025.250007","url":null,"abstract":"<p><strong>Objectives: </strong>Public health and social measures are essential tools for countries to control epidemic transmission but may also disrupt normal socioeconomic activities. This study aims to analyze differences in public health and social measures policy stringency, temporal trends, and their association with corona virus disease 2019 (COVID-19) control outcomes in 118 countries from January 2020 to September 2022, providing evidence to support the formulation of scientifically grounded public health and social measures policies.</p><p><strong>Methods: </strong>Boxplots were used to describe the distribution of overall and individual public health and social measures policy stringency scores across 118 countries during the pandemic. Linear and nonlinear models were fitted to examine temporal trends in public health and social measures policy stringency. A two-way fixed-effects model was applied to analyze the association between public health and social measures policy stringency and the effective reproduction number of COVID-19.</p><p><strong>Results: </strong>The overall public health and social measures stringency scores across the 188 countries ranged from 7.78 to 69.75. Among these countries, temporal trend models for public health and social measures stringency were statistically significant in 108 countries (all third-order polynomial models), with coefficients of determination exceeding 0.25. Overall public health and social measures stringency increased over time in 59 countries but decreased in 49 countries. After adjusting for covariates, country-level fixed effects, and time fixed effects, the overall public health and social measures policy stringency score was negatively associated with effective reproduction number (<i>β</i>'=-0.076, <i>P</i><0.05). Five individual public health and social measures components, school closures, workplace closures, gathering restrictions, domestic movement restrictions, and mask-wearing policies, were each negatively associated with the effective reproduction number (<i>β</i>'=-0.020, <i>β</i>'=-0.046, <i>β</i>'=-0.032, <i>β</i>'=-0.011, and <i>β</i>'=-0.030, respectively; all <i>P</i><0.05). In contrast, international travel restrictions were positively associated with the effective reproduction number (<i>β</i>'=0.053, <i>P</i><0.05).</p><p><strong>Conclusions: </strong>During the COVID-19 pandemic, the average intensity of public health and social measures implementation varied widely across 118 countries. School closures, workplace closures, gathering restrictions, domestic movement restrictions, and mask-wearing measures effectively curbed COVID-19 transmission, whereas the effectiveness of international travel restrictions diminished over time.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1654-1663"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.11817/j.issn.1672-7347.2025.250163
Jing DU, Jiao Li, Pule Liu, Yan Zhang, Qiangli Dong, Ning Yang, Xinru Liu
The relationship between gut microbiota and depressive disorder has become a research focus in recent years. Within the microbiota-gut-brain axis, the gut microbiota influences the onset and progression of depressive disorder primarily through the tryptophan metabolic pathway. Tryptophan, an essential amino acid in humans, is subject to dual regulation by intestinal microorganisms, which modulate its metabolic balance via inflammatory stimulation and microbial metabolite production. In depression, excessive activation of the kynurenine branch of tryptophan metabolism leads to the accumulation of proinflammatory and neurotoxic metabolites, thereby exacerbating neuroinflammation in the brain. Intervention studies indicate that the antidepressant-like effects of probiotics and traditional Chinese medicine are associated with remodeling of the gut microbiota, restoration of tryptophan metabolic balance, and alleviation of neuroinflammation. Furthermore, targeted inhibition of kynurenine 3-monooxygenase can mitigate neuroinflammation by regulating microglial activity, thus improving depressive-like behaviors. In summary, the metabolite-inflammation axis represents a central node in the interaction regulation between tryptophan metabolism and the microbiota-gut-brain axis. This provides a theoretical foundation for developing novel therapeutic strategies targeting depression through modulation of gut microbiota-mediated tryptophan metabolism.
{"title":"[Mechanisms by which the gut microbiota regulates depressive disorder via the tryptophan metabolic pathway].","authors":"Jing DU, Jiao Li, Pule Liu, Yan Zhang, Qiangli Dong, Ning Yang, Xinru Liu","doi":"10.11817/j.issn.1672-7347.2025.250163","DOIUrl":"10.11817/j.issn.1672-7347.2025.250163","url":null,"abstract":"<p><p>The relationship between gut microbiota and depressive disorder has become a research focus in recent years. Within the microbiota-gut-brain axis, the gut microbiota influences the onset and progression of depressive disorder primarily through the tryptophan metabolic pathway. Tryptophan, an essential amino acid in humans, is subject to dual regulation by intestinal microorganisms, which modulate its metabolic balance via inflammatory stimulation and microbial metabolite production. In depression, excessive activation of the kynurenine branch of tryptophan metabolism leads to the accumulation of proinflammatory and neurotoxic metabolites, thereby exacerbating neuroinflammation in the brain. Intervention studies indicate that the antidepressant-like effects of probiotics and traditional Chinese medicine are associated with remodeling of the gut microbiota, restoration of tryptophan metabolic balance, and alleviation of neuroinflammation. Furthermore, targeted inhibition of kynurenine 3-monooxygenase can mitigate neuroinflammation by regulating microglial activity, thus improving depressive-like behaviors. In summary, the metabolite-inflammation axis represents a central node in the interaction regulation between tryptophan metabolism and the microbiota-gut-brain axis. This provides a theoretical foundation for developing novel therapeutic strategies targeting depression through modulation of gut microbiota-mediated tryptophan metabolism.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 7","pages":"1263-1270"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The application of photodynamic therapy in solid tumors has attracted increasing attention in recent years, and the efficiency of photosensitizers is a crucial determinant of therapeutic efficacy. This study aims to evaluate the cytotoxic effects of a novel photosensitizer, PEG-MTPABZ-PyC, in photodynamic therapy against gastric cancer cells.
Methods: Gastric cancer MKN45 cells were treated with PEG-MTPABZ-PyC. A high-content live-cell imaging system was used to assess the cellular uptake kinetics and subcellular localization of the photosensitizer. The cytotoxic effects of PEG-MTPABZ-PyC-mediated photodynamic therapy were examined using the cell counting kit-8 (CCK-8) assay and flow cytometry, while the intrinsic cytotoxicity of the photosensitizer alone was verified by the CCK-8 assay. Intracellular reactive oxygen species (ROS) generation after photodynamic therapy was detected using 2'-7'-dichlorodihydrofluorescein diacetate (DCFH-DA).
Results: PEG-MTPABZ-PyC alone exhibited no cytotoxicity toward MKN45 cells, indicating excellent cytocompatibility. The compound efficiently entered cells within 6 hours and localized predominantly in lysosomes. Upon light irradiation, PEG-MTPABZ-PyC-mediated photodynamic therapy induced significant cytotoxicity compared with the control group (P<0.05) and generated abundant intracellular ROS.
Conclusions: The novel photosensitizer PEG-MTPABZ-PyC demonstrates potent photodynamic cytotoxicity against gastric cancer cells, showing promising potential for further development in gastric cancer photodynamic therapy.
{"title":"[Cytotoxic effects of the novel photosensitizer PEG<b>-</b>MTPABZ<b>-</b>PyC<b>-</b>mediated photodynamic therapy on gastric cancer cells].","authors":"Lingjuan Chen, Qi Wang, Lu Wang, Yifei Shen, Haibin Wang, Hengxin Wang, Xuejie Su, Meixu Lei, Xianxia Chen, Chengjin Ai, Yifan Li, Yali Zhou","doi":"10.11817/j.issn.1672-7347.2025.240601","DOIUrl":"10.11817/j.issn.1672-7347.2025.240601","url":null,"abstract":"<p><strong>Objectives: </strong>The application of photodynamic therapy in solid tumors has attracted increasing attention in recent years, and the efficiency of photosensitizers is a crucial determinant of therapeutic efficacy. This study aims to evaluate the cytotoxic effects of a novel photosensitizer, PEG-MTPABZ-PyC, in photodynamic therapy against gastric cancer cells.</p><p><strong>Methods: </strong>Gastric cancer MKN45 cells were treated with PEG-MTPABZ-PyC. A high-content live-cell imaging system was used to assess the cellular uptake kinetics and subcellular localization of the photosensitizer. The cytotoxic effects of PEG-MTPABZ-PyC-mediated photodynamic therapy were examined using the cell counting kit-8 (CCK-8) assay and flow cytometry, while the intrinsic cytotoxicity of the photosensitizer alone was verified by the CCK-8 assay. Intracellular reactive oxygen species (ROS) generation after photodynamic therapy was detected using 2'-7'-dichlorodihydrofluorescein diacetate (DCFH-DA).</p><p><strong>Results: </strong>PEG-MTPABZ-PyC alone exhibited no cytotoxicity toward MKN45 cells, indicating excellent cytocompatibility. The compound efficiently entered cells within 6 hours and localized predominantly in lysosomes. Upon light irradiation, PEG-MTPABZ-PyC-mediated photodynamic therapy induced significant cytotoxicity compared with the control group (<i>P</i><0.05) and generated abundant intracellular ROS.</p><p><strong>Conclusions: </strong>The novel photosensitizer PEG-MTPABZ-PyC demonstrates potent photodynamic cytotoxicity against gastric cancer cells, showing promising potential for further development in gastric cancer photodynamic therapy.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 7","pages":"1137-1144"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145439465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Objectives: </strong>Intrantering retained products of conception (RPOC) are common postpartum or post-abortion complications. Although surgical management is effective, it carries risks such as endometrial injury and potential negative impacts on fertility. Retrospective studies suggest that non-surgical treatment may be safe and effective for selected patients with RPOC; however, prospective evidence remains lacking. This study aims to prospectively evaluate the effectiveness and safety of non-surgical management for RPOC.</p><p><strong>Methods: </strong>Clinical data of patients diagnosed with intrauterine RPOC by ultrasound and presenting for the first time at the outpatient clinic of the Department of Gynecology and Obstetrics of the Third Xiangya Hospital, Central South University, from January 2023 to December 2024 were prospectively collected. Outcomes assessed included spontaneous expulsion of retained tissue, conversion to surgical treatment, and the incidence of heavy bleeding or infection during non-surgical management.</p><p><strong>Results: </strong>A total of 275 patients with intrauterine RPOC were enrolled. Among them, 181 patients (65.82%) experienced spontaneous expulsion, 25 (9.09%) remained under non-surgical management, and 69 (25.09%) converted to surgical treatment. Of the 69 patients, 64 had no complications but opted for surgery due to unwillingness to continue waiting, while 5 patients underwent emergency hospitalization for heavy bleeding and subsequently converted to surgery after medical stabilization. Among the 181 patients with spontaneous expulsion, the median time to RPOC resolution was 81.0 (57.0, 106.5) days. The distribution of expulsion time was as follows: with 30 days, 3 cases (1.66%); 31-60 days, 45 cases (24.86%); 61-90 days, 59 cases (32.60%); 91-120 days, 45 cases (24.86%); ≥121 days, 29 cases (16.02%). For the 69 patients who underwent surgery, the median waiting time was 73 (53, 101) days. Time-to-surgery distribution was as follows: within 30 days of pregnancy termination, 5 cases (7.25%); 31-60 days, 14 cases (20.29%); 61-90 days, 26 cases (37.68%); 91-120 days, 12 cases (17.39%); ≥121 days, 12 cases (17.39%). During non-surgical management, 8 patients (2.91%) developed heavy bleeding; all were successfully managed with inpatient medical treatment, with marked reduction in bleeding, and none required uterine artery embolization or hysterectomy. Among these, 5 converted to surgery, while 3 chose to continue non-surgical management and subsequently expelled the retained tissue spontaneously. Four patients showed elevated C-reactive protein levels, but none exhibited clinical signs of infection. For the 64 complication-free patients who elected surgery due to personal preference, paired comparisons between their complications between their initial and preoperative evaluations showed significant reductions in β-human chorionic gonadotropin (β-hCG), uterine volume, and maximum diameter of reta
{"title":"[Effectiveness and safety of non-surgical management for intrauterine retained products of conception: A prospective observational study].","authors":"Xingyi Gao, Jingrong Deng, Zixuan Cui, Xiangyang Zeng, Dabao Xu","doi":"10.11817/j.issn.1672-7347.2025.250107","DOIUrl":"10.11817/j.issn.1672-7347.2025.250107","url":null,"abstract":"<p><strong>Objectives: </strong>Intrantering retained products of conception (RPOC) are common postpartum or post-abortion complications. Although surgical management is effective, it carries risks such as endometrial injury and potential negative impacts on fertility. Retrospective studies suggest that non-surgical treatment may be safe and effective for selected patients with RPOC; however, prospective evidence remains lacking. This study aims to prospectively evaluate the effectiveness and safety of non-surgical management for RPOC.</p><p><strong>Methods: </strong>Clinical data of patients diagnosed with intrauterine RPOC by ultrasound and presenting for the first time at the outpatient clinic of the Department of Gynecology and Obstetrics of the Third Xiangya Hospital, Central South University, from January 2023 to December 2024 were prospectively collected. Outcomes assessed included spontaneous expulsion of retained tissue, conversion to surgical treatment, and the incidence of heavy bleeding or infection during non-surgical management.</p><p><strong>Results: </strong>A total of 275 patients with intrauterine RPOC were enrolled. Among them, 181 patients (65.82%) experienced spontaneous expulsion, 25 (9.09%) remained under non-surgical management, and 69 (25.09%) converted to surgical treatment. Of the 69 patients, 64 had no complications but opted for surgery due to unwillingness to continue waiting, while 5 patients underwent emergency hospitalization for heavy bleeding and subsequently converted to surgery after medical stabilization. Among the 181 patients with spontaneous expulsion, the median time to RPOC resolution was 81.0 (57.0, 106.5) days. The distribution of expulsion time was as follows: with 30 days, 3 cases (1.66%); 31-60 days, 45 cases (24.86%); 61-90 days, 59 cases (32.60%); 91-120 days, 45 cases (24.86%); ≥121 days, 29 cases (16.02%). For the 69 patients who underwent surgery, the median waiting time was 73 (53, 101) days. Time-to-surgery distribution was as follows: within 30 days of pregnancy termination, 5 cases (7.25%); 31-60 days, 14 cases (20.29%); 61-90 days, 26 cases (37.68%); 91-120 days, 12 cases (17.39%); ≥121 days, 12 cases (17.39%). During non-surgical management, 8 patients (2.91%) developed heavy bleeding; all were successfully managed with inpatient medical treatment, with marked reduction in bleeding, and none required uterine artery embolization or hysterectomy. Among these, 5 converted to surgery, while 3 chose to continue non-surgical management and subsequently expelled the retained tissue spontaneously. Four patients showed elevated C-reactive protein levels, but none exhibited clinical signs of infection. For the 64 complication-free patients who elected surgery due to personal preference, paired comparisons between their complications between their initial and preoperative evaluations showed significant reductions in β-human chorionic gonadotropin (β-hCG), uterine volume, and maximum diameter of reta","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"50 9","pages":"1624-1631"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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