Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.585
J. Chui, K. Ong
Purpose: Achieving the desired post-operative refraction in cataract surgery requires accurate calculations for intraocular lens (IOL) power. Latest-generation formulae use anterior-chamber depth (ACD)—the distance from the corneal apex to the anterior surface of the lens—as one of the parameters to predict the post-operative IOL position within the eye, termed the effective lens position (ELP). Significant discrepancies between predicted and actual ELP result in refractive surprise. This study aims to improve the predictability of ELP. We hypothesise that predictions based on the distance from the corneal apex to the mid-sagittal plane of the cataractous lens would more accurately reflect the position of the principal plane of the non-angulated IOL within the capsular bag. Accordingly, we propose that predictions derived from ACD + ½LT (length thickness) would be superior to those from ACD alone. Design: Retrospective cohort study, comparing ELP predictions derived from ACD to aproposed prediction parameter. Method: This retrospective study includes data from 162 consecutive cataract surgery cases, with posterior-chamber IOL (AlconSN60WF) implantation. Pre- and postoperative biometric measurements were made using the IOLMaster700 (ZEISS, Jena, Germany). The accuracy and reliability of ELP predictions derived from ACD and ACD + ½LT were compared using software-aided analyses. Results: An overall reduction in average ELP prediction error (PEELP) was achieved using the proposed parameter (root-mean-square-error [RMSE] = 0.50 mm), compared to ACD (RMSE = 1.57 mm). The mean percentage PEELP, comparing between eyes of different axial lengths, was 9.88% ± 3.48% and −34.9% ± 4.79% for predictions derived from ACD + ½LT and ACD, respectively. A 44.10% ± 5.22% mean of differences was observed (p < 0.001). Conclusion: ACD + ½LT predicts ELP with greater accuracy and reliability than ACD alone; its use in IOL power calculation formulae may improve refractive outcomes.
{"title":"Improving the prediction of effective lens position for intraocular lens power calculations","authors":"J. Chui, K. Ong","doi":"10.35119/ASJOO.V17I2.585","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.585","url":null,"abstract":"Purpose: Achieving the desired post-operative refraction in cataract surgery requires accurate calculations for intraocular lens (IOL) power. Latest-generation formulae use anterior-chamber depth (ACD)—the distance from the corneal apex to the anterior surface of the lens—as one of the parameters to predict the post-operative IOL position within the eye, termed the effective lens position (ELP). Significant discrepancies between predicted and actual ELP result in refractive surprise. This study aims to improve the predictability of ELP. We hypothesise that predictions based on the distance from the corneal apex to the mid-sagittal plane of the cataractous lens would more accurately reflect the position of the principal plane of the non-angulated IOL within the capsular bag. Accordingly, we propose that predictions derived from ACD + ½LT (length thickness) would be superior to those from ACD alone. \u0000Design: Retrospective cohort study, comparing ELP predictions derived from ACD to aproposed prediction parameter. \u0000Method: This retrospective study includes data from 162 consecutive cataract surgery cases, with posterior-chamber IOL (AlconSN60WF) implantation. Pre- and postoperative biometric measurements were made using the IOLMaster700 (ZEISS, Jena, Germany). The accuracy and reliability of ELP predictions derived from ACD and ACD + ½LT were compared using software-aided analyses. \u0000Results: An overall reduction in average ELP prediction error (PEELP) was achieved using the proposed parameter (root-mean-square-error [RMSE] = 0.50 mm), compared to ACD (RMSE = 1.57 mm). The mean percentage PEELP, comparing between eyes of different axial lengths, was 9.88% ± 3.48% and −34.9% ± 4.79% for predictions derived from ACD + ½LT and ACD, respectively. A 44.10% ± 5.22% mean of differences was observed (p < 0.001). \u0000Conclusion: ACD + ½LT predicts ELP with greater accuracy and reliability than ACD alone; its use in IOL power calculation formulae may improve refractive outcomes.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46864325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.561
F. Adibelli, Sevim Çakmak
Purpose: To analyze the outcomes of surgical repair of canalicular lacerations with a round-tipped pigtail probe and silicone tube implantation. Methods: A retrospective review was conducted of the case records of 64 patients who presented to the Ophthalmology Department of Harran University between 2010 and 2015 and underwent surgical repair of canalicular lacerations. Each patient’s age, gender, nationality, mechanism of injury, injured canaliculi, and follow-up time were evaluated. In addition to the anatomical and functional results, complications were also analyzed. Results: A total of 64 patients, 51 (79.7%) males and 13 (20.3%) females, with a mean age at presentation of 14.6 years (range: 1-69 years) were enrolled. Forty-six patients were aged <15 years (71.9%). Forty-two patients (65.6%) had lower canalicular lacerations, and 19 patients had isolated upper canalicular lacerations (29.7%). At the final follow-up (mean: 33.7 months), anatomical success was observed in all patients. Conclusion: Silicone tube implantation using a round-tipped pigtail probe is an effective method that facilitates anatomical and functional success in cases of canalicular laceration.
{"title":"The repair of canalicular lacerations with an annular silicone tube and round-tipped pigtail probe","authors":"F. Adibelli, Sevim Çakmak","doi":"10.35119/ASJOO.V17I2.561","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.561","url":null,"abstract":"Purpose: To analyze the outcomes of surgical repair of canalicular lacerations with a round-tipped pigtail probe and silicone tube implantation. \u0000Methods: A retrospective review was conducted of the case records of 64 patients who presented to the Ophthalmology Department of Harran University between 2010 and 2015 and underwent surgical repair of canalicular lacerations. Each patient’s age, gender, nationality, mechanism of injury, injured canaliculi, and follow-up time were evaluated. In addition to the anatomical and functional results, complications were also analyzed. \u0000Results: A total of 64 patients, 51 (79.7%) males and 13 (20.3%) females, with a mean age at presentation of 14.6 years (range: 1-69 years) were enrolled. Forty-six patients were aged <15 years (71.9%). Forty-two patients (65.6%) had lower canalicular lacerations, and 19 patients had isolated upper canalicular lacerations (29.7%). At the final follow-up (mean: 33.7 months), anatomical success was observed in all patients. \u0000Conclusion: Silicone tube implantation using a round-tipped pigtail probe is an effective method that facilitates anatomical and functional success in cases of canalicular laceration.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43357387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.532
H. Pai, M. R. Reddy
An 88-year-old female presented with redness in the left eye of one-month duration. On examination, the left eye showed 3 mm of proptosis with dilated and tortuous episcleral vessels and relative afferent pupillary defect. Intraocular pressure was 60 mmHg and showed open angles on gonioscopy with cup disc ratio of 0.8 in OS. A diagnosis of secondary open-angle glaucoma due to elevated episcleral venous pressure (EVP) was made. Magnetic resonance venogram revealed thrombosis of transverse and sigmoid sinus on the left side. This is the first case report of secondary open-angle glaucoma due to elevated EVP following thrombosis of transverse and sigmoid sinus.
{"title":"Secondary glaucoma due to thrombosis of sigmoid and transverse sinus","authors":"H. Pai, M. R. Reddy","doi":"10.35119/ASJOO.V17I2.532","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.532","url":null,"abstract":"An 88-year-old female presented with redness in the left eye of one-month duration. On examination, the left eye showed 3 mm of proptosis with dilated and tortuous episcleral vessels and relative afferent pupillary defect. Intraocular pressure was 60 mmHg and showed open angles on gonioscopy with cup disc ratio of 0.8 in OS. A diagnosis of secondary open-angle glaucoma due to elevated episcleral venous pressure (EVP) was made. Magnetic resonance venogram revealed thrombosis of transverse and sigmoid sinus on the left side. This is the first case report of secondary open-angle glaucoma due to elevated EVP following thrombosis of transverse and sigmoid sinus.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"142-146"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42481066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.579
Fariha S. Wali, Muhammad Jawed, Rafeen Talpur, N. Shaikh, Shehnilla Shujaat, K. Talpur
Introduction: Pterygium excision is a commonly encountered surgery with different methods being used. These procedures range from simple excision to use of grafts. Limbal conjunctival autograft is currently the most popular surgical procedure. The most common method of autograft fixation is suturing. But it has its own drawbacks like increased operating time, post-operative discomfort, inflammation, buttonholes, necrosis, giant papillary conjunctivitis, scarring, and granuloma formation. Glue is widely used due to many advantages like easy fixation of the graft, shorter operation time, and reduction in complications and post-operative discomfort but at the same time has some disadvantages also like high cost, the risk of transmission of infectionsand inactivation by iodine preparations. Purpose: In the following study, we describe a simple method of accomplishing conjunctival autograft adherence during pterygium surgery avoiding possible complications associated with the use of fibrin glue or sutures. Design: Prospective study. Method: We used conjunctival autograft, which was not sutured or glued to the scleral bed. The fibrin formed from the oozing blood was used to get the graft adhesion to the scleral bed. This study was approved by institutional review board, and written consent form was taken from each participant. Results: The suture-less and glue-free conjunctival autograft was found to have excellent results in terms of surgical outcome as well as post-operative recovery. In addition, risk of side effects related to sutures and glue was eliminated. Conclusion: Suture-less and glue-free conjunctival autograft is a new, easy, and cheaper technique for the management of pterygium.
{"title":"Pterygium excision with suture-less and glue-free conjunctival autograft","authors":"Fariha S. Wali, Muhammad Jawed, Rafeen Talpur, N. Shaikh, Shehnilla Shujaat, K. Talpur","doi":"10.35119/ASJOO.V17I2.579","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.579","url":null,"abstract":"Introduction: Pterygium excision is a commonly encountered surgery with different methods being used. These procedures range from simple excision to use of grafts. Limbal conjunctival autograft is currently the most popular surgical procedure. The most common method of autograft fixation is suturing. But it has its own drawbacks like increased operating time, post-operative discomfort, inflammation, buttonholes, necrosis, giant papillary conjunctivitis, scarring, and granuloma formation. Glue is widely used due to many advantages like easy fixation of the graft, shorter operation time, and reduction in complications and post-operative discomfort but at the same time has some disadvantages also like high cost, the risk of transmission of infectionsand inactivation by iodine preparations. \u0000Purpose: In the following study, we describe a simple method of accomplishing conjunctival autograft adherence during pterygium surgery avoiding possible complications associated with the use of fibrin glue or sutures. \u0000Design: Prospective study. \u0000Method: We used conjunctival autograft, which was not sutured or glued to the scleral bed. The fibrin formed from the oozing blood was used to get the graft adhesion to the scleral bed. This study was approved by institutional review board, and written consent form was taken from each participant. \u0000Results: The suture-less and glue-free conjunctival autograft was found to have excellent results in terms of surgical outcome as well as post-operative recovery. In addition, risk of side effects related to sutures and glue was eliminated. \u0000Conclusion: Suture-less and glue-free conjunctival autograft is a new, easy, and cheaper technique for the management of pterygium.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47320516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.750
K. Ong
Dear Readers, We would like to announce that Asian Journal of Ophthalmology (Asian JO) is now a fully online, open-access journal, without the registration requirements for readers. Although Asian JO is not listed on MEDLINE’S PubMed yet, it is indexed in Scopus and Google Scholar. Articles can be found either through those services or through our extensive archive. Asian JO was the official journal of the Southeast Asian Glaucoma Interest Group (SEAGIG). It was initially published in 1998 and, at that time, was one of the few journals in Asia for authors to publish in. Asian JO is now an international journal serving authors and readers around the world with a publishing team in three continents. The first publisher of Asian JO was Scientific Communications, based in Hong Kong, which later relocated to New Zealand. When the publisher retired, it became inactive. Fortunately, Professor Paul Chew along with his team at National University of Singapore managed to keep it afloat until Kugler Publications of the Netherlands became its official publisher. Paul asked me to join him in the role as Chief Editor as he needed to devote more time to develop his inventions, which include the micropulse transcleral laser therapy for glaucoma and the Paul Glaucoma Implant shunt. I was introduced to Asian JO when I asked Paul for advice on which journal to publish an article on the Ong Eye Speculum for glaucoma surgery. Asian JO promotes the publication of novel ideas and surgical techniques. Brief reports and case reports can convey clinical gems that will improve the management of ophthalmology patients. Some journals reject papers describing innovative ideas because they may not conform to the standard research presentation format, but we believe this is a crucial part of the process of scientific discovery. We have also re-established our role as the official journal of Asia-Pacific Glaucoma Society. For this reason, the next issue of Asian JO will be dedicated to abstracts for the Asia-Pacific Glaucoma Congress (APGC), to be held in Kuala Lumpur on August 14-16, 2020. Hence, Kugler Publications and Asian JO will be present at this conference, and we hope to meet readers and authors to discuss how we can improve the journal. With kind regards,Dr. Keith OngChief Editor
{"title":"Letter to our readers","authors":"K. Ong","doi":"10.35119/ASJOO.V17I2.750","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.750","url":null,"abstract":"Dear Readers, \u0000We would like to announce that Asian Journal of Ophthalmology (Asian JO) is now a fully online, open-access journal, without the registration requirements for readers. Although Asian JO is not listed on MEDLINE’S PubMed yet, it is indexed in Scopus and Google Scholar. Articles can be found either through those services or through our extensive archive. \u0000Asian JO was the official journal of the Southeast Asian Glaucoma Interest Group (SEAGIG). It was initially published in 1998 and, at that time, was one of the few journals in Asia for authors to publish in. Asian JO is now an international journal serving authors and readers around the world with a publishing team in three continents. \u0000The first publisher of Asian JO was Scientific Communications, based in Hong Kong, which later relocated to New Zealand. When the publisher retired, it became inactive. Fortunately, Professor Paul Chew along with his team at National University of Singapore managed to keep it afloat until Kugler Publications of the Netherlands became its official publisher. Paul asked me to join him in the role as Chief Editor as he needed to devote more time to develop his inventions, which include the micropulse transcleral laser therapy for glaucoma and the Paul Glaucoma Implant shunt. I was introduced to Asian JO when I asked Paul for advice on which journal to publish an article on the Ong Eye Speculum for glaucoma surgery. \u0000Asian JO promotes the publication of novel ideas and surgical techniques. Brief reports and case reports can convey clinical gems that will improve the management of ophthalmology patients. Some journals reject papers describing innovative ideas because they may not conform to the standard research presentation format, but we believe this is a crucial part of the process of scientific discovery. \u0000We have also re-established our role as the official journal of Asia-Pacific Glaucoma Society. For this reason, the next issue of Asian JO will be dedicated to abstracts for the Asia-Pacific Glaucoma Congress (APGC), to be held in Kuala Lumpur on August 14-16, 2020. Hence, Kugler Publications and Asian JO will be present at this conference, and we hope to meet readers and authors to discuss how we can improve the journal. \u0000With kind regards,Dr. Keith OngChief Editor","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43183257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-17DOI: 10.35119/ASJOO.V17I1.643
K. Ong, L. Ong
Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.
{"title":"Avoiding BAK in postoperative eye drops reduces the need for subconjunctival 5-FU injections post-trabeculectomy","authors":"K. Ong, L. Ong","doi":"10.35119/ASJOO.V17I1.643","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I1.643","url":null,"abstract":"Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. \u0000Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. \u0000Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. \u0000Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"128-131"},"PeriodicalIF":0.0,"publicationDate":"2020-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43151872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-17DOI: 10.35119/ASJOO.V17I1.445
N. Lim, J. Males
Aim: To determine whether there is an association between Fuchs endothelial corneal dystrophy (FECD) and shorter axial length (AL), shallower anterior chamber depth (ACD) and higher spherical equivalent (SE). In addition, to evaluate whether there is a correlation between AL and severity of corneal decompensation in FECD, using corneal thickness as a proxy. Design: Retrospective cohort study. Methods: This was a single-centre study conducted in a cornea clinic in Sydney, Australia. Detailed clinical measurements of 91 eyes of 50 FECD patients were compared with 110 eyes of 55 controls. Main outcome measures included AL, ACD and SE. Other outcome measures included central corneal thickness, visual acuity, intraocular pressure and keratometry. Results: Mean AL of FECD patients was 23.6 mm (standard deviation [SD] ±0.9 mm), compared with 24.7 mm (SD ±1.8 mm) for controls (1.1 mm difference [95% confidence interval [CI] 0.5-1.6], p < 0.001, independent sample t-test); corresponding means for ACD were 3.0 and 3.3 mm (0.32 mm difference [95%CI 0.2-0.5], p < 0.001, independent t-test). Eleven out of the 22 FECD patients with available refraction data had hypermetropic refraction compared with 16 out of 36 controls (p = 0.68, chi-squared test). The mean SE of FECD patients (+0.10D) was higher than controls (−1.33D) (1.4D difference [0.1-2.8], p = 0.04, independent t-test). No statistically significant correlation was found between AL and corneal thickness (p = 0.28, linear regression). Conclusion: In this retrospective cohort study, a strong association was established between FECD and small eyes, with shorter AL and shallower ACD, compared with controls. These results have important implications for surgical planning, as shorter AL and ACD in FECD patients likely contribute to their high risk of corneal decompensation following cataract surgery.
{"title":"Fuchs endothelial corneal dystrophy and small eyes","authors":"N. Lim, J. Males","doi":"10.35119/ASJOO.V17I1.445","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I1.445","url":null,"abstract":"Aim: To determine whether there is an association between Fuchs endothelial corneal dystrophy (FECD) and shorter axial length (AL), shallower anterior chamber depth (ACD) and higher spherical equivalent (SE). In addition, to evaluate whether there is a correlation between AL and severity of corneal decompensation in FECD, using corneal thickness as a proxy. \u0000Design: Retrospective cohort study. \u0000Methods: This was a single-centre study conducted in a cornea clinic in Sydney, Australia. Detailed clinical measurements of 91 eyes of 50 FECD patients were compared with 110 eyes of 55 controls. Main outcome measures included AL, ACD and SE. Other outcome measures included central corneal thickness, visual acuity, intraocular pressure and keratometry. \u0000Results: Mean AL of FECD patients was 23.6 mm (standard deviation [SD] ±0.9 mm), compared with 24.7 mm (SD ±1.8 mm) for controls (1.1 mm difference [95% confidence interval [CI] 0.5-1.6], p < 0.001, independent sample t-test); corresponding means for ACD were 3.0 and 3.3 mm (0.32 mm difference [95%CI 0.2-0.5], p < 0.001, independent t-test). Eleven out of the 22 FECD patients with available refraction data had hypermetropic refraction compared with 16 out of 36 controls (p = 0.68, chi-squared test). The mean SE of FECD patients (+0.10D) was higher than controls (−1.33D) (1.4D difference [0.1-2.8], p = 0.04, independent t-test). No statistically significant correlation was found between AL and corneal thickness (p = 0.28, linear regression). \u0000Conclusion: In this retrospective cohort study, a strong association was established between FECD and small eyes, with shorter AL and shallower ACD, compared with controls. These results have important implications for surgical planning, as shorter AL and ACD in FECD patients likely contribute to their high risk of corneal decompensation following cataract surgery.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2020-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48075372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-17DOI: 10.35119/ASJOO.V17I1.459
Anitha Venugopal, S. Peri, R. Chandra, M. Ravindran, R. Ramakrishnan
We report the case of a 1-year-old child who presented with complaints of redness and defective vision since birth. The child had no systemic abnormalities. On examination, complete keratinization of the bulbar conjunctiva and cornea was noted with dry, lustreless and irregular surface. Corneal sensation was intact. Orbital MRI revealed bilateral agenesis of the lacrimal gland with normal salivary glands. The child was given vitamin supplementation, cyclosporine eye drops along with lubricants and tape tarsorrhaphy in the night. Permanent occlusion of both the lower puncta was done. There was decreased ocular surface congestion, with frequent wetting of the ocular surface, which continued in the months to follow. We present a case of isolated bilateral lacrimal gland agenesis with normal salivary glands, a rare cause of dry eye in children. An early diagnosis and conservative management can help in maintaining functional vision in such cases.
{"title":"Isolated bilateral congenital lacrimal gland agenesis presenting as dry eye in childhood: a rare entity","authors":"Anitha Venugopal, S. Peri, R. Chandra, M. Ravindran, R. Ramakrishnan","doi":"10.35119/ASJOO.V17I1.459","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I1.459","url":null,"abstract":"We report the case of a 1-year-old child who presented with complaints of redness and defective vision since birth. The child had no systemic abnormalities. On examination, complete keratinization of the bulbar conjunctiva and cornea was noted with dry, lustreless and irregular surface. Corneal sensation was intact. Orbital MRI revealed bilateral agenesis of the lacrimal gland with normal salivary glands. The child was given vitamin supplementation, cyclosporine eye drops along with lubricants and tape tarsorrhaphy in the night. Permanent occlusion of both the lower puncta was done. There was decreased ocular surface congestion, with frequent wetting of the ocular surface, which continued in the months to follow. We present a case of isolated bilateral lacrimal gland agenesis with normal salivary glands, a rare cause of dry eye in children. An early diagnosis and conservative management can help in maintaining functional vision in such cases.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"74-77"},"PeriodicalIF":0.0,"publicationDate":"2020-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45392864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To assess the characteristics and treatment outcomes of patients with primary ocular adnexal lymphoma (OAL) in Northern Thailand. Design: Retrospective cohort study. Methods: Data was collected from electronic medical records and operative notes from Chiang Mai University Hospital between January 2009 and December 2014. All available tissue biopsies of 54 patients were reviewed by agreement of two pathologists. The clinical characteristics and treatment outcomes were collected and analyzed. Results: A total number of 54 patients were identified of which 57.4% were female. The median age was 61.0 years (range, 4-86). The most common subtype of lymphoma was extranodal marginal zone lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT) (n = 46, 85.2%). Seventy-five percent of the patients presented with a mass at the ocular adnexa, while 14.8% of the patients presented with proptosis. The sites of origin were as follows: lacrimal (46.3%), orbit (31.5%), conjunctiva (13%) and eyelid (7.4%). Two-thirds of the patients had Ann-Arbor Stage I, while 22% of patients had Stage IV. The majority of the patients (68.1%) had a low-risk international prognosis index (IPI). Treatment modalities involved field radiation (IFRT, 50%), chemotherapy (31.6%), combined chemoradiotherapy (7.9%) and surgical resection (10.5%). The overall response rate was 100% with a complete response rate of 77.8%. In patients with low-grade lymphoma, including MALT lymphoma, the 3-year progression-free survival (PFS) and overall survival were 69.9% and 92.5%, respectively. Conclusion: ENMZL of MALT was the major subtype of primary OAL. Radiotherapy was an effective treatment for the lower stages of disease providing a high response rate and encouraging survival outcomes.
{"title":"Characteristics and treatment outcomes of patients with primary ocular adnexal lymphoma in Northern Thailand","authors":"Kasem Seresirikachorn, Sakarin Ausayakhun, Damrong Wiwatwongwana, Ponsak Mahanupab, Teerada Daroontum, L. Norasetthada","doi":"10.35119/ASJOO.V17I1.475","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I1.475","url":null,"abstract":"Purpose: To assess the characteristics and treatment outcomes of patients with primary ocular adnexal lymphoma (OAL) in Northern Thailand. Design: Retrospective cohort study. Methods: Data was collected from electronic medical records and operative notes from Chiang Mai University Hospital between January 2009 and December 2014. All available tissue biopsies of 54 patients were reviewed by agreement of two pathologists. The clinical characteristics and treatment outcomes were collected and analyzed. Results: A total number of 54 patients were identified of which 57.4% were female. The median age was 61.0 years (range, 4-86). The most common subtype of lymphoma was extranodal marginal zone lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT) (n = 46, 85.2%). Seventy-five percent of the patients presented with a mass at the ocular adnexa, while 14.8% of the patients presented with proptosis. The sites of origin were as follows: lacrimal (46.3%), orbit (31.5%), conjunctiva (13%) and eyelid (7.4%). Two-thirds of the patients had Ann-Arbor Stage I, while 22% of patients had Stage IV. The majority of the patients (68.1%) had a low-risk international prognosis index (IPI). Treatment modalities involved field radiation (IFRT, 50%), chemotherapy (31.6%), combined chemoradiotherapy (7.9%) and surgical resection (10.5%). The overall response rate was 100% with a complete response rate of 77.8%. In patients with low-grade lymphoma, including MALT lymphoma, the 3-year progression-free survival (PFS) and overall survival were 69.9% and 92.5%, respectively. Conclusion: ENMZL of MALT was the major subtype of primary OAL. Radiotherapy was an effective treatment for the lower stages of disease providing a high response rate and encouraging survival outcomes.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49050658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-17DOI: 10.35119/ASJOO.V17I1.516
A. Victor, T. Gondhowiardjo, R. Dharma, S. Jusman, Vivi R. Yandri, Ressa Yuneta, Rizky E. P. Yuriza
Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.
{"title":"Intercellular adhesive molecule-1 (ICAM-1) in proliferative diabetic retinopathy","authors":"A. Victor, T. Gondhowiardjo, R. Dharma, S. Jusman, Vivi R. Yandri, Ressa Yuneta, Rizky E. P. Yuriza","doi":"10.35119/ASJOO.V17I1.516","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I1.516","url":null,"abstract":"Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. \u0000Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. \u0000Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). \u0000Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"120-127"},"PeriodicalIF":0.0,"publicationDate":"2020-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48291596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：