Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.553
D. Mahajan, A. Verma, R. Sharma
Vortex keratopathy is a common side effect of amiodarone, which is a class III antiarrhythmic agent. We describe a 50-year-old man who developed vortex keratopahy with amiodarone 200 mg BD for atrial fibrillation since two years. The daily (400 mg/day) and cumulative dose (100 g) combined with the length of therapy is associated with the toxicity. Toxic effects may also be observed at lower maintenance doses, as observed in this patient. This case indicates that multi-organ toxicity due to amiodarone may develop even with short-term use and a low maintenance dose. Having been off the medication for two months, it is expected that the deposition pattern will diminish, as is the case for the vast majority of patients.
{"title":"Amiodarone-induced vortex keratopathy at a low maintenance dose","authors":"D. Mahajan, A. Verma, R. Sharma","doi":"10.35119/ASJOO.V17I2.553","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.553","url":null,"abstract":"Vortex keratopathy is a common side effect of amiodarone, which is a class III antiarrhythmic agent. We describe a 50-year-old man who developed vortex keratopahy with amiodarone 200 mg BD for atrial fibrillation since two years. The daily (400 mg/day) and cumulative dose (100 g) combined with the length of therapy is associated with the toxicity. Toxic effects may also be observed at lower maintenance doses, as observed in this patient. This case indicates that multi-organ toxicity due to amiodarone may develop even with short-term use and a low maintenance dose. Having been off the medication for two months, it is expected that the deposition pattern will diminish, as is the case for the vast majority of patients.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"170-172"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44791413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.569
P. Prasher
We describe a modified surgical technique for performing the triple procedure that combines deep anterior lamellar keratoplasty with manual small-incision cataract surgery. This technique offers advantages in terms of undergoing a single surgery as compared to the staged procedure, preservation of the host Descemet’s membrane and endothelium, and ability to perform cataract surgery in a closed-chamber setting.
{"title":"Deep anterior lamellar keratoplasty with manual small-incision cataract surgery: a modification of the triple procedure","authors":"P. Prasher","doi":"10.35119/ASJOO.V17I2.569","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.569","url":null,"abstract":"We describe a modified surgical technique for performing the triple procedure that combines deep anterior lamellar keratoplasty with manual small-incision cataract surgery. This technique offers advantages in terms of undergoing a single surgery as compared to the staged procedure, preservation of the host Descemet’s membrane and endothelium, and ability to perform cataract surgery in a closed-chamber setting.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"196-202"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47589778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.577
S. Jeganathan, Suneetha Nithyanandam, Reji Thomas, S. Karat
The most common cause of unilateral blindness in paediatric age groups, especially in developing countries, is ocular trauma. Trauma to the eye is very debilitating to the patient; hence, managing various types of penetrating and blunt injury to the eye provide a challenge to the ophthalmologist. It is simply preventable by the supervisionof the parents and caregivers. We will be discussing one such case and our experience in dealing with a fish hook injury to the eye in a 12-year-old boy—the challenges we faced and the precautions we took to give a good visual outcome.
{"title":"Fish hook injury to the eye and its management","authors":"S. Jeganathan, Suneetha Nithyanandam, Reji Thomas, S. Karat","doi":"10.35119/ASJOO.V17I2.577","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.577","url":null,"abstract":"The most common cause of unilateral blindness in paediatric age groups, especially in developing countries, is ocular trauma. Trauma to the eye is very debilitating to the patient; hence, managing various types of penetrating and blunt injury to the eye provide a challenge to the ophthalmologist. It is simply preventable by the supervisionof the parents and caregivers. We will be discussing one such case and our experience in dealing with a fish hook injury to the eye in a 12-year-old boy—the challenges we faced and the precautions we took to give a good visual outcome.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"222-226"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45858864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.533
Bhupinder Kaur, Shamim Ahmad, H. Ashraf, Giby Thachil
Purpose: Effect of combination of various antibiotics on Staphylococcus epidermidis biofilm. Study design: Experimental study. Methods: The biofilm-producing strains of S. epidermidis were isolated from 100 patients undergoing cataract surgery before instillation of any antibiotic. The strains were subjected to sensitivity test to various antibiotic combinations. The most effective agent was selected and its minimum inhibitory concentration was determined by broth dilution method. The statistics wereperformed using SPSS Version 23 (IBM Corp.) and Chi square test. Results: A total of 22 biofilm-positive samples were obtained. The combinations of vancomycin with ceftazidime (p < 0.05) followed by moxifloxacin with cefuroxime (p < 0.05) were found to be the most effective. Antibiofilm activity was also shown by other antibiotic combination. The minimum inhibitory concentration of vancomycin and ceftazidime in 11 samples was 2.5 and 2.8 mg/ml, while in the rest of the samples, it was 2.5 and 5.6 mg/ml, respectively. The minimum inhibitory concentration of moxifloxacin and cefuroxime was 0.125 and 2.81 mg/ml, respectively. Conclusion: In our study, we conclude that antibiotics are effective in eradicating biofilms.
{"title":"In vitro study on the effect of antibiotic combinations on Staphylococcus epidermidis biofilms","authors":"Bhupinder Kaur, Shamim Ahmad, H. Ashraf, Giby Thachil","doi":"10.35119/ASJOO.V17I2.533","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.533","url":null,"abstract":"Purpose: Effect of combination of various antibiotics on Staphylococcus epidermidis biofilm. \u0000Study design: Experimental study. \u0000Methods: The biofilm-producing strains of S. epidermidis were isolated from 100 patients undergoing cataract surgery before instillation of any antibiotic. The strains were subjected to sensitivity test to various antibiotic combinations. The most effective agent was selected and its minimum inhibitory concentration was determined by broth dilution method. The statistics wereperformed using SPSS Version 23 (IBM Corp.) and Chi square test. \u0000Results: A total of 22 biofilm-positive samples were obtained. The combinations of vancomycin with ceftazidime (p < 0.05) followed by moxifloxacin with cefuroxime (p < 0.05) were found to be the most effective. Antibiofilm activity was also shown by other antibiotic combination. The minimum inhibitory concentration of vancomycin and ceftazidime in 11 samples was 2.5 and 2.8 mg/ml, while in the rest of the samples, it was 2.5 and 5.6 mg/ml, respectively. The minimum inhibitory concentration of moxifloxacin and cefuroxime was 0.125 and 2.81 mg/ml, respectively. \u0000Conclusion: In our study, we conclude that antibiotics are effective in eradicating biofilms.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"147-155"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44017192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.572
C. Vidhya, K. Murali, R. Sowmya
Aim: To evaluate safety and efficacy of reconstituted atropine 0.01% eye drops for Indian children with myopic progression. Methods: Fifty children with progressive myopia with their spherical equivalent increasing at least 0.75 D in 6 months (0.75 to 1.50 D) were put on reconstituted atropine 0.01%. Ocular examination, including near vision, near point of accommodation (NPA), pupil size and axial length, was done. Subjective symptoms of glare and photophobia were noted. Systemic side effects were documented. Analysis was done using Microsoft Excel 2010. Results: The average age of patients was 9.5 years (range 5 to 14 years) and they were followed up for 1 year. Average mesopic and photopic pupil size was 5 and 4 mm, respectively. Average NPA was 9 cm. Mean increase in spherical equivalence was 0.18 D over 6 months. Average increase in axial length was 0.12 ± 0.11 mm over 6 months and 0.2 ± 0.29 mm over 1 year. Average increase in spherical equivalent over 6 months was 0.07 ± 0.19 D and over 1 year was 0.32 ± 0.29 D. No systemic side effects were recorded. Conclusion: Reconstituted atropine 0.01% eye drops is safe and efficacious in slowingthe progression of myopia in Indian children.
{"title":"Safety and efficacy of reconstituted atropine 0.01% eye drops for Indian children with myopic progression","authors":"C. Vidhya, K. Murali, R. Sowmya","doi":"10.35119/ASJOO.V17I2.572","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.572","url":null,"abstract":"Aim: To evaluate safety and efficacy of reconstituted atropine 0.01% eye drops for Indian children with myopic progression. \u0000Methods: Fifty children with progressive myopia with their spherical equivalent increasing at least 0.75 D in 6 months (0.75 to 1.50 D) were put on reconstituted atropine 0.01%. Ocular examination, including near vision, near point of accommodation (NPA), pupil size and axial length, was done. Subjective symptoms of glare and photophobia were noted. Systemic side effects were documented. Analysis was done using Microsoft Excel 2010. \u0000Results: The average age of patients was 9.5 years (range 5 to 14 years) and they were followed up for 1 year. Average mesopic and photopic pupil size was 5 and 4 mm, respectively. Average NPA was 9 cm. Mean increase in spherical equivalence was 0.18 D over 6 months. Average increase in axial length was 0.12 ± 0.11 mm over 6 months and 0.2 ± 0.29 mm over 1 year. Average increase in spherical equivalent over 6 months was 0.07 ± 0.19 D and over 1 year was 0.32 ± 0.29 D. No systemic side effects were recorded. \u0000Conclusion: Reconstituted atropine 0.01% eye drops is safe and efficacious in slowingthe progression of myopia in Indian children.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"209-215"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43336251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.571
J. Leon, R. Medalle
Objective: To present a case report of asymptomatic post-traumatic chronic hypotony in which the cause was undetected until phacoemulsification. Methodology: Case report. Results: A 55-year-old female’s left eye suffered blunt trauma causing hyphema and iritis, which were successfully managed; however, up to a year after, the intraocular pressure (IOP) ranged from 3 to 5 mmHg and the anterior chamber remained very shallow (Van Herick grade 4) with the lens–iris diaphragm pushed anteriorly with difficulty assessing the angles for recession or clefts . Visual acuity was initially 20/20 upon resolution of the hyphema but worsened to 20/40 a year after, presumably due to a developing cataract. Periodic dilated fundus examinations revealed no hypotony maculopathy or choroidal effusions. Prior to phacoemulsification, ultrasound biomicroscopy (UBM) revealed 360 degrees of mild peripheral choroidal effusions. During phacoemulsification, after intraocular lens insertion, direct gonioscopy revealed a supero-nasal cyclodialysis cleft (2 clock hours) and this was repaired intraoperatively with direct cyclopexy through a partial thickness scleral flap. Postoperatively, the vision improved to 20/20 without correction and the IOP normalized to 16 to 18 mmHg. Conclusion: Chronic hypotony post-trauma may be asymptomatic and the cause may not be clinically evident and may be detected by UBM (choroidal effusion). In our case, the proximate aetiology (cyclodialysis cleft) of the effusion was only observed intraoperatively after phacoemulsification for which cyclopexy was performed which increased the IOP to physiologic levels.
{"title":"Asymptomatic chronic hypotony due to subclinical choroidal effusion after blunt trauma","authors":"J. Leon, R. Medalle","doi":"10.35119/ASJOO.V17I2.571","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.571","url":null,"abstract":"Objective: To present a case report of asymptomatic post-traumatic chronic hypotony in which the cause was undetected until phacoemulsification. \u0000Methodology: Case report. \u0000Results: A 55-year-old female’s left eye suffered blunt trauma causing hyphema and iritis, which were successfully managed; however, up to a year after, the intraocular pressure (IOP) ranged from 3 to 5 mmHg and the anterior chamber remained very shallow (Van Herick grade 4) with the lens–iris diaphragm pushed anteriorly with difficulty assessing the angles for recession or clefts . Visual acuity was initially 20/20 upon resolution of the hyphema but worsened to 20/40 a year after, presumably due to a developing cataract. Periodic dilated fundus examinations revealed no hypotony maculopathy or choroidal effusions. Prior to phacoemulsification, ultrasound biomicroscopy (UBM) revealed 360 degrees of mild peripheral choroidal effusions. During phacoemulsification, after intraocular lens insertion, direct gonioscopy revealed a supero-nasal cyclodialysis cleft (2 clock hours) and this was repaired intraoperatively with direct cyclopexy through a partial thickness scleral flap. Postoperatively, the vision improved to 20/20 without correction and the IOP normalized to 16 to 18 mmHg. \u0000Conclusion: Chronic hypotony post-trauma may be asymptomatic and the cause may not be clinically evident and may be detected by UBM (choroidal effusion). In our case, the proximate aetiology (cyclodialysis cleft) of the effusion was only observed intraoperatively after phacoemulsification for which cyclopexy was performed which increased the IOP to physiologic levels.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49179063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.559
Hugo Pena-Verdeal, Covadonga Vázquez-Sánchez, Jacobo Garcia-Queiruga, C. García-Resúa
Purpose: Tear film hyperosmolarity is considered one the core mechanism of the dry eye along with the tear film stability. Many tear physiological variables oscillate during the day. This study was designed to assess the differences in tear film osmolarity between morning and afternoon in a group of healthy subjects. Materials and methods: A total of 25 healthy subjects who fulfilled the study’s inclusion criteria were enrolled for the study. Tear osmolarity was measured using the TearLab™ system in two separated sessions, at 9.30 am and 6.30 pm. A paired t-test and a Bland–Altman test were used to assess the differences between sessions. Results: Tear osmolarity (mean ± SD) was 309.96 ± 9.00 and 296.48 ± 12.98 mOsm/l at 9.30 am and 6.30 pm, respectively, being significantly lower at 6.30 pm than at 9.30 am (mean difference ± SD = 13.48 ± 8.69 mOsm/l; paired t-test; p < 0.001). Conclusions: Tear film osmolarity does appear to have some influence by the time of day in healthy patients.
{"title":"Differences of tear film osmolarity between two time-points of the day in healthy subjects","authors":"Hugo Pena-Verdeal, Covadonga Vázquez-Sánchez, Jacobo Garcia-Queiruga, C. García-Resúa","doi":"10.35119/ASJOO.V17I2.559","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.559","url":null,"abstract":"Purpose: Tear film hyperosmolarity is considered one the core mechanism of the dry eye along with the tear film stability. Many tear physiological variables oscillate during the day. This study was designed to assess the differences in tear film osmolarity between morning and afternoon in a group of healthy subjects. \u0000Materials and methods: A total of 25 healthy subjects who fulfilled the study’s inclusion criteria were enrolled for the study. Tear osmolarity was measured using the TearLab™ system in two separated sessions, at 9.30 am and 6.30 pm. A paired t-test and a Bland–Altman test were used to assess the differences between sessions. \u0000Results: Tear osmolarity (mean ± SD) was 309.96 ± 9.00 and 296.48 ± 12.98 mOsm/l at 9.30 am and 6.30 pm, respectively, being significantly lower at 6.30 pm than at 9.30 am (mean difference ± SD = 13.48 ± 8.69 mOsm/l; paired t-test; p < 0.001). \u0000Conclusions: Tear film osmolarity does appear to have some influence by the time of day in healthy patients.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"173-181"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69888437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.531
I. Temblador-Barba, Carlos Gálvez-Prieto-Moreno, M. Martínez-Jiménez
Purpose: To describe the management of a case of an arachnoid cyst of the optic nerve. Methods: Here, we report a 27-year-old female patient who was diagnosed with arachnoid cyst of the left sheath optic nerve, drained in several occasions, and came to our service because of progressive blurring in the left eye. Outcomes: Due to the location of the lesion, excision could not be performed; so we performed a microsurgical incision with drain by nasal superior transconjunctival approach. After that, the visual acuity (VA) was 0.7, and we could observe that the size of the cyst was smaller than previous examinations with magnetic resonance imaging (MRI). Nowadays, the patient keeps the same asymptomatic VA. So medical appointments are planned to closely follow-up, and periodically, we perform new scan images and visual fields. Conclusions: Arachnoid cysts of the optic nerve are rare, benign, slowly progressive conditions. They can be asymptomatic lesions, especially smaller ones, or may result in proptosis and loss of vision because of the compression. The best imaging examination for their follow-up is MRI. They should be differentiated from optic nerve sheath meningioma and other conditions.
{"title":"Arachnoid cyst of the optic nerve: therapeutic management and progress","authors":"I. Temblador-Barba, Carlos Gálvez-Prieto-Moreno, M. Martínez-Jiménez","doi":"10.35119/ASJOO.V17I2.531","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.531","url":null,"abstract":"Purpose: To describe the management of a case of an arachnoid cyst of the optic nerve. \u0000Methods: Here, we report a 27-year-old female patient who was diagnosed with arachnoid cyst of the left sheath optic nerve, drained in several occasions, and came to our service because of progressive blurring in the left eye. \u0000Outcomes: Due to the location of the lesion, excision could not be performed; so we performed a microsurgical incision with drain by nasal superior transconjunctival approach. After that, the visual acuity (VA) was 0.7, and we could observe that the size of the cyst was smaller than previous examinations with magnetic resonance imaging (MRI). Nowadays, the patient keeps the same asymptomatic VA. So medical appointments are planned to closely follow-up, and periodically, we perform new scan images and visual fields. \u0000Conclusions: Arachnoid cysts of the optic nerve are rare, benign, slowly progressive conditions. They can be asymptomatic lesions, especially smaller ones, or may result in proptosis and loss of vision because of the compression. The best imaging examination for their follow-up is MRI. They should be differentiated from optic nerve sheath meningioma and other conditions.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"137-141"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44709545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.560
G. Yaghoobi, Abbas Hosseini Rad, S. Heydari, Malihe Nikandish
Purpose: This study was conducted to show diverse clinical presentation of ocular surface squamous neoplasia with a rare presentation of caruncle squamous cell carcinoma (SCC). Methods: All cases that had suspicious ocular lesion were included in the treatment study. A detailed history including demographic data was obtained. Clinical features regarding the type of lesion, location, and the involvement of cornea were evaluated. For all patients, excisional biopsy following “Shield’s no-touch technique” with 3 to 4 mm margins of uninvolved tissue and cryotherapy at excisional margins was done. All specimens were sent for a histopathological evaluation. Topical chemotherapy (mitomycin C, 0.02%) was used as an adjunctive therapy following surgical excision for large and diffuse ocular surface tumors. All patients were subjected to long-term regular follow-ups. Results: Twenty-six patients (18 men and 8 women) with a mean age of 54.2 years were enrolled in this study. The results showed that the most common localization was bulbar conjunctiva (92%). Nodular lesions (46.5%) and SCC (57.5%) were the most common clinical and histopathological features, respectively. We observed one rare case of primary SCC of the left caruncle in a 68-year-old man who had an asymptomatic medial canthal mass. Recurrence was found in two patients with SCC, one of them having an orbital extension. Conclusion: The early suspicion of ocular surface neoplasia will be accomplished with a simple excision in most cases, leading to a favorable outcome except in severe progressive cases.
目的：本研究旨在显示眼表鳞状肿瘤的不同临床表现，以及罕见的疣状鳞状细胞癌（SCC）。方法：所有有可疑眼部病变的病例均纳入治疗研究。获得了包括人口统计数据在内的详细历史。评估了病变类型、位置和角膜受累的临床特征。对于所有患者，按照“Shield’s no touch technique”进行切除活检，切除3至4 mm的未受累组织边缘，并在切除边缘进行冷冻治疗。所有标本均送去进行组织病理学评估。大面积弥漫性眼表肿瘤手术切除后，局部化疗（丝裂霉素C，0.02%）作为辅助治疗。所有患者都接受了长期定期随访。结果：26名患者（18名男性和8名女性）被纳入本研究，平均年龄为54.2岁。结果表明，最常见的定位是球结膜（92%）。结节性病变（46.5%）和SCC（57.5%）分别是最常见的临床和组织病理学特征。我们观察到一例罕见的原发性左肩胛骨鳞状细胞癌病例，该病例发生在一名68岁的男子身上，他有一个无症状的内眼角肿块。两名鳞状细胞癌患者复发，其中一名患者的眼眶扩张。结论：在大多数情况下，早期怀疑眼表肿瘤可以通过简单的切除术来完成，除了严重的进行性病例外，其他情况都会得到良好的结果。
{"title":"Ocular surface squamous neoplasia: a case series","authors":"G. Yaghoobi, Abbas Hosseini Rad, S. Heydari, Malihe Nikandish","doi":"10.35119/ASJOO.V17I2.560","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.560","url":null,"abstract":"Purpose: This study was conducted to show diverse clinical presentation of ocular surface squamous neoplasia with a rare presentation of caruncle squamous cell carcinoma (SCC). \u0000Methods: All cases that had suspicious ocular lesion were included in the treatment study. A detailed history including demographic data was obtained. Clinical features regarding the type of lesion, location, and the involvement of cornea were evaluated. For all patients, excisional biopsy following “Shield’s no-touch technique” with 3 to 4 mm margins of uninvolved tissue and cryotherapy at excisional margins was done. All specimens were sent for a histopathological evaluation. Topical chemotherapy (mitomycin C, 0.02%) was used as an adjunctive therapy following surgical excision for large and diffuse ocular surface tumors. All patients were subjected to long-term regular follow-ups. \u0000Results: Twenty-six patients (18 men and 8 women) with a mean age of 54.2 years were enrolled in this study. The results showed that the most common localization was bulbar conjunctiva (92%). Nodular lesions (46.5%) and SCC (57.5%) were the most common clinical and histopathological features, respectively. We observed one rare case of primary SCC of the left caruncle in a 68-year-old man who had an asymptomatic medial canthal mass. Recurrence was found in two patients with SCC, one of them having an orbital extension. \u0000Conclusion: The early suspicion of ocular surface neoplasia will be accomplished with a simple excision in most cases, leading to a favorable outcome except in severe progressive cases.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"182-187"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47190330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-30DOI: 10.35119/ASJOO.V17I2.537
Camille Elaine Zabala, Jubaida Mangondato-Aquino, J. M. Martinez, J. Leon
Purpose: To determine mean macular and retinal nerve fiber layer (RNFL) thickness of myopic Filipinos using spectral domain optical coherence tomography (SD-OCT) and to evaluate influence of age, gender, and degree of myopia. Design: Observational clinic-based cohort. Methods: Participants were divided into two groups: low-moderate myopia [spherical equivalent (SE) -0.50 D to -6.00 D] and high-pathologic myopia (SE 26.5 mm). Subgroup analyses between low myopia (refraction -3.00 D to -6.00 D), and high myopia (> -6.00 D to -8.00 D) and pathologic myopia (more than -8.00 D) were done. Macular and RNFL thickness were measured by a SD-OCT and axial length (AL) with non-contact biometry. Results: Of 156 eyes, 88/156 (56%) had low-moderate myopia, 68/156 (44%) had high-pathologic myopia. There were 67/156 (43%) male and 89/156 (57%) female subjects. Mean central foveal subfield thickness measurements were 264 ± 24 μm for low myopia, 258 ± 17 μm for moderate myopia, 253 ± 25 μm for high myopia, and 218 ± 48 μm for pathologic myopia. Mean RNFL thickness measurements were 105.62 ± 3.89 μmfor low myopia, 97.6 ± 2.45 μm for moderate myopia, 85.9 ± 3.87 μm for high myopia, and 75.14 ± 3.89 μm for pathologic myopia. Average SE (p < 0.0001) decreased while AL (p < 0.0001) increased with more myopia. Myopia and age significantly affected macular and RNFL thickness parameters except for the following where only the degree of myopia was a significant factor: central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses. Conclusion: Retinal SD-OCT thickness measurements decreased with increasing level of myopia and age. Central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses may be more appropriate SD-OCT parameters among myopic Filipino patients to monitor for glaucoma since they may be less influenced by age.
{"title":"Retinal thickness among normal myopic Filipinos using spectral domain optical coherence tomography","authors":"Camille Elaine Zabala, Jubaida Mangondato-Aquino, J. M. Martinez, J. Leon","doi":"10.35119/ASJOO.V17I2.537","DOIUrl":"https://doi.org/10.35119/ASJOO.V17I2.537","url":null,"abstract":"Purpose: To determine mean macular and retinal nerve fiber layer (RNFL) thickness of myopic Filipinos using spectral domain optical coherence tomography (SD-OCT) and to evaluate influence of age, gender, and degree of myopia. \u0000Design: Observational clinic-based cohort. \u0000Methods: Participants were divided into two groups: low-moderate myopia [spherical equivalent (SE) -0.50 D to -6.00 D] and high-pathologic myopia (SE 26.5 mm). Subgroup analyses between low myopia (refraction -3.00 D to -6.00 D), and high myopia (> -6.00 D to -8.00 D) and pathologic myopia (more than -8.00 D) were done. Macular and RNFL thickness were measured by a SD-OCT and axial length (AL) with non-contact biometry. \u0000Results: Of 156 eyes, 88/156 (56%) had low-moderate myopia, 68/156 (44%) had high-pathologic myopia. There were 67/156 (43%) male and 89/156 (57%) female subjects. Mean central foveal subfield thickness measurements were 264 ± 24 μm for low myopia, 258 ± 17 μm for moderate myopia, 253 ± 25 μm for high myopia, and 218 ± 48 μm for pathologic myopia. Mean RNFL thickness measurements were 105.62 ± 3.89 μmfor low myopia, 97.6 ± 2.45 μm for moderate myopia, 85.9 ± 3.87 μm for high myopia, and 75.14 ± 3.89 μm for pathologic myopia. Average SE (p < 0.0001) decreased while AL (p < 0.0001) increased with more myopia. Myopia and age significantly affected macular and RNFL thickness parameters except for the following where only the degree of myopia was a significant factor: central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses. \u0000Conclusion: Retinal SD-OCT thickness measurements decreased with increasing level of myopia and age. Central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses may be more appropriate SD-OCT parameters among myopic Filipino patients to monitor for glaucoma since they may be less influenced by age.","PeriodicalId":39864,"journal":{"name":"Asian Journal of Ophthalmology","volume":"17 1","pages":"156-169"},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42306152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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