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Prevalence of glaucoma in first-degree relatives of patients with primary open-angle glaucoma and normal-tension glaucoma 原发性开角型青光眼和正常眼压型青光眼患者一级亲属青光眼的患病率
Q4 Medicine Pub Date : 2018-11-21 DOI: 10.35119/asjoo.v16i2.374
Preeti Gupta, H. Pai
Objective: To determine the prevalence of glaucoma in first-degree relatives of patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Methods: Observational study of first-degree relatives of patients with POAG and NTG who were screened for glaucoma. Results: A total of 66 first-degree relatives of patients with glaucoma (POAG/NTG) were included in the study. We found a prevalence rate of 16.6%: 13.6% were diagnosed to have the disease and 3% were newly detected to have glaucoma during the study. We found that although 66.7% of the subjects were aware of the family history of glaucoma, only 36.4% were aware that they were at increased risk of developing glaucoma. Conclusion: In our study, we found high prevalence of glaucoma in first-degree relatives of patients with glaucoma. This highlights the importance of selective screening of high-risk groups such as first-degree relatives of patients with POAG/NTG.
目的:了解原发性开角型青光眼(POAG)和正常张力型青光眼(NTG)患者一级亲属中青光眼的患病率。方法:对经青光眼筛查的POAG和NTG患者的一级亲属进行观察研究。结果:共纳入66例青光眼(POAG/NTG)患者一级亲属。我们发现患病率为16.6%,其中13.6%被诊断患有该病,3%在研究期间新发现患有青光眼。我们发现,虽然66.7%的受试者知道青光眼家族史,但只有36.4%的受试者知道自己有青光眼的高风险。结论:在我们的研究中,我们发现青光眼患者的一级亲属中青光眼的患病率很高。这突出了选择性筛查高危人群的重要性,如POAG/NTG患者的一级亲属。
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引用次数: 2
Influence of anterior chamber depth on postoperative refractive outcome in Chinese eyes 前房深度对中国人眼术后屈光效果的影响
Q4 Medicine Pub Date : 2018-11-21 DOI: 10.35119/asjoo.v16i2.366
Rachel Shet Hui Wong, K. Ong
Aim or Purpose: This study aims to evaluate the refractive surprise (RS) after cataract surgery with various intraocular lens (IOL) formulas in eyes with very shallow or deep anterior chamber depth (ACD). Design: This is a prospective cohort study of patients from a private ophthalmology practice in Sydney. Methods: Thirty-one patients who had their cataract surgery in 2014 were included. The cohort consists of 20 eyes with ACD < 2.8 mm and 25 eyes with ACD > 3.2 mm. Patients’ demographic variables and their predicted refractive outcomes using the SRK-T, Haigis, Holladay 1, and Holladay 2 IOL formulas were collected. Actual refractive outcomes were obtained from consultations at least one-month postoperatively. RS was calculated from the difference between predicted refraction outcome of IOL formulas and the actual postoperative refraction achieved. Results: The linear correlations between ACD and RS were not significant (p > 0.05). In the group with ACD < 2.8 mm, the mean refractive surprise using SRK-T, Haigis, Holladay 1, and Holladay 2 formulas were -0.191 ± 0.541, -0.189 ± 0.444, -0.201 ± 0.449, and -0.154 ± 0.489 D, respectively. In the group with ACD > 3.2 mm, the mean refractive surprise using the IOL formulas were -1.364 ± 0.541, -1.420 ± 0.541, 0.027 ± 0.394, and -0.045 ± 0.343 D, respectively.  Conclusion: The positive linear correlation between ACD and RS was weak. In eyes with ACD < 2.8 mm, the least RS was found with the Holladay 2 formula, while in eyes with ACD > 3.2 mm, this was found with Holladay 1.
目的:评价前房深度极浅或极深眼白内障术后不同人工晶状体(IOL)配方的屈光意外(RS)。设计:这是一项前瞻性队列研究,患者来自悉尼一家私人眼科诊所。方法:选取2014年行白内障手术的患者31例。该队列包括ACD < 2.8 mm的20只眼和ACD > 3.2 mm的25只眼。使用SRK-T、Haigis、Holladay 1和Holladay 2人工晶状体公式收集患者的人口统计学变量及其预测屈光结果。实际屈光结果是通过术后至少一个月的会诊获得的。RS由人工晶状体配方预测屈光度与术后实际屈光度之差计算。结果:ACD与RS之间线性相关无统计学意义(p < 0.05)。在ACD < 2.8 mm组,使用SRK-T、Haigis、Holladay 1、Holladay 2公式的平均屈光惊奇D分别为-0.191±0.541、-0.189±0.444、-0.201±0.449、-0.154±0.489 D。ACD为3.2 mm组的平均屈光惊奇分别为-1.364±0.541、-1.420±0.541、0.027±0.394和-0.045±0.343 D。结论:ACD与RS呈弱线性正相关。在ACD < 2.8 mm的眼睛中,Holladay 2配方的RS最小,而在ACD≤3.2 mm的眼睛中,Holladay 1配方的RS最小。
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引用次数: 2
Bloody tears: a case of bilateral ulcerative blepharitis 双侧溃疡性睑炎血泪1例
Q4 Medicine Pub Date : 2018-11-21 DOI: 10.35119/asjoo.v16i2.376
Praveena K. Gupta, Laura Di Meglio, A. Behrens
Chronic blepharitis leading to bilateral ulceration is rare to encounter. A 49-year-old African American female presents with bloody tears, severe pain, and photophobia in both eyes. Clinical presentation called for ulceration on the upper lid margins with excavated wound which bled on gentle rubbing. A systemic health review in combination of the symptoms and clinical picture led to the diagnosis of severe ulcerative blepharitis. Immediate oral antibiotics were started along with topical antibiotic cream. Ulcerative blepharitis can be easily misdiagnosed with sebaceous cell carcinoma. The pathophysiology of ulcerative blepharitis points to synergy between infectious entity and inflammatory aetiology, with either bacterial or fungal microorganisms as the trigger agents. Almost all cases of ulcerative blepharitis should include a dermatological evaluation given there is a strong association between ulcerative blepharitis and atopic dermatitis.
慢性睑炎导致双侧溃疡是罕见的。一位49岁的非裔美国女性表现为双眼流血流泪,剧烈疼痛和畏光。临床表现为上睑缘溃疡伴创面挖出,轻揉出血。结合症状和临床表现进行系统健康检查,诊断为严重溃疡性睑炎。立即口服抗生素并使用局部抗生素乳膏。溃疡性睑炎很容易误诊为皮脂腺细胞癌。溃疡性睑缘炎的病理生理学指出感染性实体和炎症病因之间的协同作用,细菌或真菌微生物作为触发剂。鉴于溃疡性睑缘炎与特应性皮炎之间有很强的相关性,几乎所有溃疡性睑缘炎病例都应包括皮肤病学评估。
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引用次数: 0
Safety and efficacy of posterior iris claw intraocular lens fixation in aphakic patients 无晶状体患者虹膜后爪人工晶状体内固定的安全性和有效性
Q4 Medicine Pub Date : 2018-11-20 DOI: 10.35119/asjoo.v16i2.368
R. Tomy, R. Maheshwari, A. Muhammed, V. Kalikivayi, Sajeev Cherian Jacob
Purpose: To assess the indications and visual outcome of eyes undergoing posterior iris fixated intraocular lens (IFIOL) implantation for aphakia, to identify reasons for poor visual outcome, and report occurrence of complications. Methods: In this retrospective case series study, all cases of posterior IFIOL fixation performed over a 30-month period were identified retrospectively. Preoperative and postoperative evaluations comprised objective and subjective refraction, best corrected visual acuity (BCVA), slit lamp biomicroscopy, applanation tonometry, and dilated fundus examination. Results: Fifty-six eyes of 56 patients were analyzed. Mean age was 60.55 ± 17.2 years. The most common indication for IFIOL implantation was surgical aphakia following complicated cataract surgery (n = 33; 58.9%) followed by trauma (n = 10; 17.9%), dropped nucleus/IOL during primary surgery (n = 6; 10.7%), and subluxated/dislocated lens-induced glaucomas (n = 5; 8.9%). BCVA better than or equal to their preoperative BCVA was achieved in 96.43% patients. The surgical aphakia and paediatric/adolescent groups had the best visual results while the dropped nucleus/IOL group and subluxated lens-induced glaucoma groups fared poorly. On the long-term follow-up visit, the most common complication noted was pigment dusting on the corneal endothelium (65.7%). Conclusion: The long-term results suggest that posterior IFIOL implantation is a safe and effective method for correction of aphakia and can be used for a wide range of indications in eyes without adequate capsule support. It may be considered an easier and faster alternative with minimal manipulation to anterior segment structures in paediatric and post-traumatic aphakic eyes.
目的:评估虹膜后固定人工晶状体(IFIOL)植入治疗无晶状体眼的适应症和视觉效果,找出视觉效果不佳的原因,并报告并发症的发生。方法:在这项回顾性病例系列研究中,回顾性地确定了所有在30个月内进行的后人工晶状体内固定的病例。术前和术后评估包括客观和主观屈光度、最佳矫正视力(BCVA)、裂隙灯生物显微镜、压平眼压计和扩张眼底检查。结果:对56例56眼患者进行分析。平均年龄60.55±17.2岁。最常见的人工晶状体植入指征是复杂白内障手术后的手术性无晶状体眼(n=33;58.9%),随后是创伤(n=10;17.9%),初次手术中细胞核/人工晶状体脱落(n=6;10.7%),以及晶状体半脱位/脱位引起的青光眼(n=5;8.9%)。96.43%的患者的BCVA优于或等于术前BCVA。手术无晶状体组和儿童/青少年组的视觉效果最好,而落核/人工晶状体组和晶状体半脱位诱导的青光眼组的表现较差。在长期随访中,最常见的并发症是角膜内皮上的色素沉积(65.7%)。在儿科和创伤后无晶状体眼中,它可以被认为是一种更简单、更快的替代方案,对眼前节结构的操作最少。
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引用次数: 0
Glaucoma and frequent flying 青光眼和频繁飞行
Q4 Medicine Pub Date : 2018-11-18 DOI: 10.35119/asjoo.v16i2.562
K. Ong, L. Ong, L. Armellin
To evaluate the possible impact of frequent flying on glaucoma progression.
评估频繁飞行对青光眼进展的可能影响。
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引用次数: 0
Prevalence of variation in predicted refraction between different intraocular lens formulae 不同人工晶状体配方之间预测屈光度变化的患病率
Q4 Medicine Pub Date : 2018-11-18 DOI: 10.35119/asjoo.v16i2.389
K. Ong, Liaoyun Feng
Variations of 0.5 D in predicted refraction between the different intraocular lens (IOL) calculation formulae may occur in 19.4% cases. This has implications when reporting refractive surprise. It also shows that it is beneficial to consider more than one IOL formula when choosing IOL power for cataract surgery.  
在19.4%的病例中,不同人工晶状体(IOL)计算公式之间的预测折射率可能出现0.5D的变化。这在报道屈光不正时会产生影响。这也表明,在白内障手术中选择IOL功率时,考虑多个IOL公式是有益的。
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引用次数: 1
Changes in corneal properties and its effect on intraocular pressure measurement following phacoemulsification with intraocular lens implantation with or without trabeculectomy 超声乳化人工晶状体植入术伴或不伴小梁切除术后角膜特性的变化及其对眼压测量的影响
Q4 Medicine Pub Date : 2018-10-23 DOI: 10.35119/asjoo.v16i1.344
Ashim Dey, R. David, R. Asokan, R. George
Purpose: To evaluate the changes incorneal biomechanical properties and their effect on pre and postoperative differences in IOP measurement by each tonometer Design: Observational study. Methods: The study was done in subjects who underwent phacoemulsification with intraocular lens (IOL) implantation (phaco-IOL) and combined phacoemulsification with IOL implantation and trabeculectomy (phaco-trab). IOP was measured by a single trained examiner using rebound tonometer (RBT), Ocular Response Analyzer (ORA), Goldmann applanation tonometer (GAT), dynamic contour tonometer (DCT), and Tono-Pen. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using ORA, central corneal thickness (CCT) using ultrasonic pachymeter, and corneal curvature (CR) with manual keratometry. All measurements were done one week prior to surgery and after four weeks and six weeks of the two surgeries, respectively. Only the operated eye was included for analysis. Results: Twenty-nine eyes of 29 normal subjects who underwent phaco-IOL and 23 eyes of 23 glaucoma subjects who underwent phaco-trab were studied. Increase in CCT [10.2 ± 14.86 microns, p = 0.001], decrease in CH [0.82 ± 1.38 mmHg, p = 0.003] and CRF [0.97 ± 1.0 mmHg, p < 0.001] were found post-phaco-IOL, whereas post-phaco-trab decrease in CCT [16.61 ± 15.22 microns, p < 0.001], CRF [2.28 ± 1.93 mmHg, p < 0.001] with increase in CH [0.95 ± 1.89 mmHg, p = 0.03] were noted. Multiple linear regression analysis showed significant associations for change in CH and CRF with change in IOP and not with CCT and CR postoperatively. Conclusion: Alterations in CH and CRF were associated with changes in IOP measured postoperatively by different tonometers. CH and CRF changes contribute to postoperative changes in measured IOP.  
目的:评价角膜生物力学特性的变化及其对各眼压计眼压测量术前和术后差异的影响。方法:采用超声乳化联合人工晶状体植入术(phao -IOL)和超声乳化联合人工晶状体植入术联合小梁切除术(phao -trab)进行研究。眼压由一名训练有素的检查人员使用反弹眼压仪(RBT)、眼反应分析仪(ORA)、Goldmann眼压仪(GAT)、动态轮廓眼压仪(DCT)和Tono-Pen测量。采用ORA法测定角膜迟滞(CH)和角膜阻力因子(CRF),超声测厚仪测定角膜中央厚度(CCT),手工测角法测定角膜曲率(CR)。所有测量分别在手术前一周、手术后4周和6周进行。只有手术后的眼睛被纳入分析。结果:对29例正常人行晶状体人工晶状体植入术的29只眼和23例青光眼行晶状体植入术的23只眼进行研究。phaco- iol后CCT升高[10.2±14.86 μ m, p = 0.001], CH降低[0.82±1.38 mmHg, p = 0.003], CRF降低[0.97±1.0 mmHg, p < 0.001],而phaco- iol后CCT降低[16.61±15.22 μ m, p < 0.001], CRF降低[2.28±1.93 mmHg, p < 0.001], CH升高[0.95±1.89 mmHg, p = 0.03]。多元线性回归分析显示,术后CH和CRF的变化与IOP的变化有显著相关性,而与CCT和CR无关。结论:术后不同眼压计测量的眼压变化与CH和CRF的改变有关。CH和CRF的改变有助于术后测量IOP的变化。
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引用次数: 0
Cataract surgery under topical anaesthesia - white or yellow light 局部麻醉下的白内障手术-白光或黄光
Q4 Medicine Pub Date : 2018-10-23 DOI: 10.35119/asjoo.v16i1.345
K. Ong, Andrew Yue, S. Beka
To evaluate whether there is a difference in comfort level between yellow light and white light for the patient having cataract surgery under topical anaesthesia.    
评估在表面麻醉下进行白内障手术的患者在黄光和白光之间的舒适度是否存在差异。
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引用次数: 0
Bilateral simultaneous acute angle closure in an adult Nepalese woman 一名成年尼泊尔妇女双侧同时锐角闭合术
Q4 Medicine Pub Date : 2018-10-23 DOI: 10.35119/ASJOO.V16I1.348
Sabin Sahu, L. Puri
Purpose: To report a case of bilateral simultaneous angle closure in an adult Nepalese woman without any known secondary cause. Methods: Observational case report. Results: A 50-year-old Nepalese woman presented with decreased vision, pain, redness, and watering in both eyes with associated coloured haloes, nausea, and vomiting for 10 days. At presentation, her visual acuity was 20/400 in the right eye and hand motions close to face with accurate projection of rays in the left eye. Intraocular pressure was 38 mmHg in the right eye and 48 mmHg in the left eye without any antiglaucoma medications. A slit-lamp examination revealed bilateral circum-corneal conjunctival congestion, corneal edema, and shallow anterior chambers. Both pupils were mid-dilated and non-reactive to light. Gonioscopy showed closed angles in all four quadrants bilaterally. Posterior segment examination revealed normal optic disc with cup-disc-ratio of 0.3 in the right eye, and blurring of disc margin with cup-disc-ratio of 0.3 in the left eye. The patient was started on systemic acetazolamide 250 mg 4 times a day, topical brimonidine 0.2% and timolol 0.5% 2 times a day, and topical dexamethasone 6 times a day in both eyes, following which IOP reduced to 11 and 12 mmHg, respectively, the corneal edema subsided, but the anterior chamber remained shallow. Laser peripheral iridotomy was performed in the right eye and surgical peripheral iridectomy was performed in the left eye. After two weeks, vision improved to 20/30 in both eyes with normal intraocular pressure off antiglaucoma medications. Anterior chambers deepened significantly with clear corneas bilaterally. Gonioscopy at this stage showed essentially open angles with appositional closure in superior and temporal quadrants in the right eye and open angles in all four quadrants in the left eye. Posterior segment evaluation revealed normal optic disc in both eyes. Conclusions: Bilateral simultaneous acute angle closure is a rare presentation with very few reported secondary causes. We report a case of bilateral simultaneous angle closure in an adult Nepalese woman without any known secondary cause. The case was successfully managed with laser peripheral iridotomy in the right eye and surgical peripheral iridectomy in the left eye.  
目的:报告一例无任何已知次要原因的成年尼泊尔妇女双侧同时闭角的病例。方法:观察病例报告。结果:一名50岁的尼泊尔妇女在10天内出现视力下降、疼痛、发红和双眼流泪,并伴有晕染、恶心和呕吐。在演示时,她的右眼视力为20/400,手靠近面部运动,左眼光线投射准确。在没有任何抗青光眼药物的情况下,右眼的眼压为38mmHg,左眼的眼压为48mmHg。裂隙灯检查显示双侧角膜周围结膜充血、角膜水肿和浅前房。两个瞳孔都是中等放大的,对光线没有反应。双侧四个象限的性腺镜检查均呈闭角。后段检查显示右眼视盘正常,杯盘比为0.3,左眼视盘边缘模糊,杯盘比为0.3。患者开始全身服用乙酰唑胺250mg,每天4次,局部服用0.2%溴莫尼定和0.5%噻吗洛尔,每天2次,局部使用地塞米松,每天6次,随后眼压分别降至11和12毫米汞柱,角膜水肿消退,但前房仍较浅。右眼行激光周边虹膜切开术,左眼行手术周边虹膜切除术。两周后,在服用抗青光眼药物后眼压正常的情况下,双眼的视力提高到20/30。前房明显加深,两侧角膜清晰。这一阶段的性腺镜检查显示,右眼上象限和颞象限基本上是开放角,而左眼的四个象限都是开放角。后段评估显示双眼视盘正常。结论:双侧同时急性闭角是一种罕见的表现,很少有继发原因的报道。我们报告了一例无任何已知次要原因的成年尼泊尔妇女双侧同时闭角的病例。该病例成功地在右眼进行了激光周边虹膜切开术,在左眼进行了手术周边虹膜切除术。
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引用次数: 0
Knowledge, awareness, perception, and willingness towards eye donation among the literate working population 识字劳动人口对眼睛捐赠的知识、意识、感知和意愿
Q4 Medicine Pub Date : 2018-10-23 DOI: 10.35119/asjoo.v16i1.336
Justin Egnasious, Krithica Srinivasan, Ramesh S. Ve, Babu Noushad
Aim: To evaluate awareness, knowledge, and perception towards eye donation among the literate working population. Methodology: A new questionnaire on eye donation was developed from existing literature and face validation was performed among subject experts. Repeatability of the questionnaire was performed among 30 subjects. A total of 23 questions were there, out of those 6 questions for evaluating awareness, 13 questions for evaluating knowledge, and 4 questions for dertermining the subjects' perception. The questionnaire was distributed among subjects working in both the health science and non-health science fields. From their responses, knowledge, awareness, and perception towards eye donation in working literate population were assessed. A pledge form was also given along with the questionnaire to find the subjects' actual willingness. Results: Repeatability: The questions in the awareness and knowledge domain showed good repeatability (p > 0.05). More than 50 % of the parameters in the perception domain showed poor repeatability (p < 0.05).  Out of 189 subjects assessed, there were 97 health science and 92 non-health science subjects with total mean age 30 ± 7 years. Good awareness was present between health science (96%) and non-health science (94%). Only 21% of the health science and 11% of the non-health science group had good knowledge about eye donation. Only 25% said ‘yes’ to willingness about eye donation. However, only 3% filled the pledge form. No-one from the non-health science population filled the pledge form. Health science professionals showed more willingness to donate eyes compared to the non-health science group after adjusting for qualification, age ,and gender (odds ratio 2.158, p = 0.031, 95% CI (1.073, 4.341)). Study participants shared willingness to donate eyes and responded against negative perceptions such as "Family members object to eye donation” (odds: 3.75, p = 0.030, 95% CI (1.14, 12.39)), “Dislike of separating eye from the body” (odds:7.02, p =0.006, 95% CI (1.73, 28.42)), and “Donating an organ is against my religious belief” (odds: 8.51,p = 0.039, 95% CI (1.11, 65.09)). Conclusion: Our study showed that education qualification and the perception like ‘eye donation is against religious beliefs’ and ‘dislike to separate eye from the body’ showed significant effect on the willingness to donate eyes. More than awareness and knowledge, perception about eye donation had more impact on the willingness to donate eyes. Therefore, more campaigns emphasizing the importance of eye donation need to be conducted to change the perceptions about eye donation rather than improving awareness or knowledge.
目的:评估识字工作人群对眼睛捐赠的认识、知识和看法。方法:根据现有文献编制了一份关于眼睛捐赠的新问卷,并在受试者专家中进行了面部验证。问卷的可重复性在30名受试者中进行。共有23个问题,其中6个问题用于评估意识,13个问题用于评价知识,4个问题用于确定受试者的感知。问卷在健康科学和非健康科学领域的受试者中分发。从他们的回答中,评估了识字工作人群对眼睛捐赠的知识、意识和看法。还提供了一份承诺表和问卷,以了解受试者的实际意愿。结果:可重复性:意识和知识领域的问题表现出良好的可重复性(p>0.05)。感知领域超过50%的参数表现出较差的重复性(p<0.05)。在评估的189名受试者中,有97名健康科学受试者和92名非健康科学受试者,总平均年龄为30±7岁。健康科学(96%)和非健康科学(94%)之间存在良好的认识。只有21%的健康科学组和11%的非健康科学组对眼部捐献有良好的了解。只有25%的人表示愿意捐献眼睛。然而,只有3%的人填写了认捐表。非健康科学人群中没有人填写认捐表。在对资格、年龄、,和性别(比值比2.158,p=0.031,95%CI(1.073,4.341)“捐献器官违背了我的宗教信仰”(比值比:8.51,p=0.039,95%CI(1.11,65.09)。除意识和知识外,对眼睛捐赠的感知对捐赠意愿的影响更大。因此,需要开展更多强调眼睛捐赠重要性的运动,以改变人们对眼睛捐赠的看法,而不是提高意识或知识。
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引用次数: 1
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Asian Journal of Ophthalmology
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