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Leishmanicidal Activity of Plant Extracts from Sefrou, a Moroccan Focus of Leishmaniasis, against Various Leishmania Parasites in the Promastigote Stage 摩洛哥利什曼病焦点植物Sefrou提取物对Promastigote期多种利什曼原虫的杀利什曼活性研究
Q4 Medicine Pub Date : 2018-11-18 DOI: 10.3166/PHYTO-2018-0085
I. Zeouk, A. Et-Touys, M. Balouiri, H. Fellah, A. E. Lalami, K. Bekhti
According to the World Health Organization, leishmaniasis remains a major worldwide public health problem. The province of Sefrou located in the center of Morocco is a focus of cutaneous leishmaniasis. The present study aims at evaluating the antileishmanial potential of Berberis sp.,Crataegus oxyacantha, Cistus salviifolius, Ephedra altissima and Lavandula dentatafrequently used by the local population. Methanolic extracts were tested against the promastigote form ofLeishmania tropica, Leishmania majorandLeishmania infantumusing tetrazolium-based colorimetric (MTT) assay. The total phenol and flavonoids content of all extracts were determined using the Folin–Ciocalteu reagent, aluminum chloride, and potassium acetate solutions respectively. The plant extracts exhibited antileishmanial activity with variability depending on the tested strain and the plant species compared to Glucantime® used as control (IC50 (the half maximal inhibitory concentration) > 1,000 μg/mL). The best inhibition was observed with Berberis sp., againstLeishmania major(IC50 = 394.40 ± 3.02 μg/ml), andEphedra altissima(reported for the first time) againstLeishmania infantum(IC50 = 490.84 ± 3.15 μg/mL).Leishmania tropicahas shown the same sensitivity behavior toward the five extracts (in average IC50 = 540 ± 11.20 μg/mL). The total phenolic content was higher forCrataegus oxyacanthaandCistus salviifolius(140.67 ± 3.17 μg eq Gallic Acid (GA)/ mg of Extract (E) and 133.83 ± 9.03 μg eq GA/mg of E respectively), while flavonoid was higher forCistus salviifoliusandLavandula dentata(57.92 ± 2.46 μg eq Quercetin (Que)/ mg of Extract (E) and 41.53 ± 1.74 μg eq Que/mg of E). All the tested extracts present some promising aspects that may cure cutaneous leishmaniasis in the center of Morocco; further bioguided assays are needed to isolate the fractions and the bioactive molecule.
据世界卫生组织称,利什曼病仍然是一个主要的全球公共卫生问题。位于摩洛哥中部的塞弗鲁省是皮肤利什曼病的重镇。本研究旨在评价当地居民常用的小檗属、山楂属、鼠尾草属、麻黄属和薰衣草属植物的抗利什曼病潜力。采用四氮唑基比色法(MTT)测定甲醇提取物对热带利什曼原虫、大利什曼原虫和幼年利什曼原虫的抑菌作用。采用Folin-Ciocalteu试剂、氯化铝溶液和醋酸钾溶液分别测定各提取物的总酚和总黄酮含量。与对照葡聚糖®相比,该植物提取物具有抗利什曼原虫活性,其IC50(最大半数抑制浓度)为100 ~ 1000 μg/mL。其中,小檗对大利什曼原虫(IC50 = 394.40±3.02 μg/ml)的抑制效果最好,而首次报道的深草对婴儿利什曼原虫(IC50 = 490.84±3.15 μg/ml)的抑制效果最好。热带利什曼原虫对5种提取物均表现出相同的敏感性(平均IC50 = 540±11.20 μg/mL)。总酚含量较高forCrataegus oxyacanthaandCistus salviifolius(140.67±3.17μg情商没食子酸(GA) /毫克的提取(E)和133.83±9.03μg eq GA /毫克的E),而类黄酮高forCistus salviifoliusandLavandula dentata(57.92±2.46μg eq槲皮素(是)/毫克的提取(E)和41.53±1.74μg eq, /毫克的E)。所有在场的检测提取一些有前途的方面可能治愈皮肤利什曼病在摩洛哥的中心;需要进一步的生物引导分析来分离这些组分和生物活性分子。
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引用次数: 3
Probiotics, Stress, and Irritable Bowel Syndrome 益生菌、压力和肠易激综合征
Q4 Medicine Pub Date : 2018-11-18 DOI: 10.3166/PHYTO-2018-0087
V. Théodorou
Irritable bowel syndrome (IBS) is a functional, gastrointestinal disease characterized by a combination of chronic or recurrent symptoms such as abdominal pain and abnormal bowel habit. Most of the IBS features occur without identifiable organic cause and are strongly influenced by stress and anxiety suggesting the involvement of brain–gut interactions in this disease. Microbiota changes have also been reported such as decreased abundance of the genera Bifidobacterium and Lactobacillus and increased firmicutes: bacteroidetes ratio but there is no consensus on a specific IBS microbiota signature. Psychological stress in rodents impacts intestinal epithelial barrier integrity as well as the composition of microbial communities and induces visceral pain, providing an interesting model for IBS pathophysiology investigation. Modulation of the intestinal microbiota using probiotics in preclinical trials prevents stress-induced visceral hypersensitivity directly through probiotic metabolites production or indirectly through prevention of the intestinal barrier function impairment. The clinical efficacy of probiotic treatments has also been suggested but the use of different scales to analyze the mean differences of symptoms in various studies has limited the ability of all existing meta-analyses in IBS to confirm the effectiveness of probiotics on major IBS symptoms and patient quality of life.
肠易激综合征(IBS)是一种功能性胃肠道疾病,其特征是慢性或复发症状,如腹痛和排便习惯异常。大多数IBS特征发生时没有可识别的器质性原因,并且受到压力和焦虑的强烈影响,这表明这种疾病与脑-肠相互作用有关。微生物群的变化也有报道,如双歧杆菌属和乳杆菌属的丰度降低,坚壁菌门与拟杆菌门的比例增加,但对特定的IBS微生物群特征还没有达成共识。啮齿类动物的心理压力影响肠上皮屏障的完整性以及微生物群落的组成,并诱导内脏疼痛,为IBS的病理生理学研究提供了一个有趣的模型。在临床前试验中使用益生菌调节肠道微生物群可以直接通过益生菌代谢物的产生或间接通过预防肠道屏障功能损伤来预防应激诱导的内脏超敏反应。也有人提出了益生菌治疗的临床疗效,但在各种研究中使用不同的量表来分析症状的平均差异,限制了所有现有IBS荟萃分析确认益生菌对主要IBS症状和患者生活质量的有效性的能力。
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引用次数: 1
Laurus nobilisL. and the Study of its Biological Activityin vitro 月桂。及其体外生物活性研究
Q4 Medicine Pub Date : 2018-11-05 DOI: 10.3166/PHYTO-2018-0084
M. Mehani, Z. Goumni, A. Salhi, N. Salhi, L. Segni, V. Terzi, C. Morcia
This work focuses on the study of the antimicrobial activity of the essential oil (EO) ofLaurus nobilisL. plant. The extraction of essential oil of the aerial parts ofLaurus nobilisL. was conducted by the hydrodistillation method. Antimicrobial activity test was performed on five bacterial strains (Klebsiella pneumoniae,Escherichia coli,Proteus mirabilis,Enterobacter cloacae,Enterococcus faecalis). The results showed thatLaurus nobilisEO has moderate antibacterial activity. In addition, the antifungal activity of theLaurus nobilisL. EO was analyzed; the direct contact method was performed onFusarium sporotrichioidesin different EO concentrations (0.05, 0.25, and 0.5% of EO). The results showed that this essential oil has significant antifungal activity on this strain; there was a 100% growth inhibition at a concentration of 0.5%.
本文主要研究了锦葵精油的抗菌活性。植物对锦葵地上部分精油的提取。通过加氢蒸馏法进行。对5株细菌(肺炎克雷伯菌、大肠杆菌、奇异变形杆菌、阴沟肠杆菌、粪肠球菌)进行了抗菌活性试验。结果表明,月桂具有中等的抗菌活性。此外,月桂的抗真菌活性。分析EO;对不同EO浓度(0.05%、0.25%和0.5%的EO)的镰刀菌孢子虫进行直接接触法。结果表明,该精油对该菌株具有显著的抗真菌活性;在0.5%的浓度下存在100%的生长抑制。
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引用次数: 0
Détermination des effets synergiques ou antagonistes de plusieurs substances antimicrobiennes : application d’un plan d’expériences factoriel 几种抗菌物质协同或拮抗作用的测定:因子实验设计的应用
Q4 Medicine Pub Date : 2018-11-04 DOI: 10.3166/PHYTO-2018-0076
T. Belaiche, F. Leriche
Suite à l’émergence de germes mutants résistants aux antibiotiques classiques, les recherches sont en train de s’orienter vers des substances naturelles. En effet, plusieurs huiles essentielles (HE) extraites de plantes sont pourvues d’un large spectre antibactérien et antifongique. L’utilisation de combinaisons (HE/HE) ou (HE/antibiotique) peut s’avérer plus efficace contre ces germes. En se fondant sur la méthodologie des plans d’expériences factoriels, nous avons mis au point une méthode permettant de quantifier et de classer l’activité antimicrobienne de plusieurs terpènes simultanément envers Staphylococcus aureus. Leurs effets d’interactions synergiques ou antagonistes ont également pu être quantifiés moyennant un nombre restreint d’essais.
随着对常规抗生素具有耐药性的突变细菌的出现,研究正在转向天然物质。事实上,从植物中提取的几种精油(HE)具有广谱抗菌和抗真菌作用。使用(He/He)或(He/抗生素)组合可能对这些细菌更有效。基于因子实验设计的方法,我们开发了一种方法来量化和分类几种萜烯同时对金黄色葡萄球菌的抗菌活性。它们的协同或拮抗相互作用效应也可以通过有限数量的试验进行量化。
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引用次数: 0
Phytochemical Screening, Phenolic Compounds Content, Antioxidant, Anti-inflammatory, and Antimicrobial Properties of Pachylobus balsamifera Guillaum from Gabon 加蓬香膏的植物化学筛选、酚类化合物含量、抗氧化、抗炎和抗菌特性
Q4 Medicine Pub Date : 2018-10-26 DOI: 10.3166/PHYTO-2018-0059
Cédric Sima-Obiang, Rick-Leonid Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, J. Ondo, Louis-Clément Obame-Engonga, E. Nsi-Emvo
The goal of this work is to evaluate the antioxidant anti-inflammatory properties, the phenolic compounds content, and antimicrobial potential of water–acetone, water–ethanol, and water extracts of Pachylobus balsamifera. The phenolic compounds content was evaluated to estimate their effect on the antioxidant, anti-inflammatory, and antimicrobial potential of the plant. Antioxidant activities were examined by DPPH (2,2-diphenyl-1- picrylhydrazyl) and ABTS (2,2′-azino-bis) assays. Antiinflammatory activity was determined by the proteins denaturation inhibition method. All plant extracts were evaluated against six reference strains, eleven clinical isolates, and two fungal strains. Phenols content was highest in the water–acetone and water–ethanol extracts. The water extract showed strong anti-inflammatory effect. The water–acetone extract presented a strong antioxidant property and the highest antimicrobial activities against Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella Sp., and Neisseria meningitidis. The tested microorganisms showed sensitivity to all extracts of the plant with the exception of Escherichia coli 105182 CIP, Listeria innocua LMG 135668 BHI, Salmonella enterica, Salmonella typhi, and Neisseria gonorrhea. Our results suggest that Pachylobus balsamifera extracts contain antioxidant, anti-inflammatory, and antimicrobial properties.
本工作的目的是评估香脂的水-丙酮、水-乙醇和水提取物的抗氧化抗炎特性、酚类化合物含量和抗菌潜力。评估酚类化合物的含量,以评估其对植物抗氧化、抗炎和抗菌潜力的影响。通过DPPH(2,2-二苯基-1-苦基肼基)和ABTS(2,2′-叠氮基双)测定抗氧化活性。采用蛋白质变性抑制法测定其抗炎活性。所有植物提取物均针对6个参考菌株、11个临床分离株和2个真菌菌株进行了评估。苯酚含量在水-丙酮和水-乙醇提取物中最高。水提取物具有很强的抗炎作用。水-丙酮提取物具有较强的抗氧化性能,对铜绿假单胞菌、鲍曼不动杆菌、沙门氏菌和脑膜炎奈瑟菌具有最高的抗菌活性。除了大肠杆菌105182 CIP、无害李斯特菌LMG 135668 BHI、肠炎沙门氏菌、伤寒沙门氏菌和淋病奈瑟菌外,测试的微生物对植物的所有提取物都显示出敏感性。我们的研究结果表明,香脂提取物具有抗氧化、抗炎和抗菌特性。
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引用次数: 4
Étude comparative de la composition chimique des huiles essentielles de Tetraclinis articulata (Vahl) Masters du Maroc 摩洛哥关节四角菌(Vahl)精油化学成分的比较研究
Q4 Medicine Pub Date : 2018-10-26 DOI: 10.3166/PHYTO-2018-0082
M. Bourkhiss, A. Chaouch, M. Ouhssine, B.Bourkhiss
La qualité et la variabilité de la composition chimique de l’huile essentielle isolée de tronc de Tetraclinis articulata ont été étudiées dans trois régions bien représentatives dans la tétraclinaie marocaine. Les rendements moyens obtenus par hydrodistillation sont de 1,10 % pour la région de Debdou (Maroc oriental), 2,70 % pour Essaouira nord (Haut Atlas) et 1,45 % pour Ben Karrich (Rif occidental). L’analyse par CPG et GC/MS a permis de mettre en évidence cinq constituants majoritaires dans chaque localité. Ces constituants présentent une variabilité quantitative et sont, respectivement, le carvacrol (71,03 ; 47,17 et 11,84 %), le γ-curcumène (12,95 ; 20,27 et 13,24 %), la thymoquinone (1,58 ; 11,50 et 33,82 %), le cédrol (6,48 ; 7,76 et 16,64 %) et le 4-terpinéol (2,03 ; 3,09 et 3,83 %).
研究了摩洛哥四角菊茎分离精油的品质和化学成分的变异性。水蒸馏的平均产量在Debdou地区(摩洛哥东部)为1.10%,在Essaouira北部(高阿特拉斯)为2.70%,在Ben Karrich地区(Rif西部)为1.45%。通过CPG和GC/MS分析,在每个地点确定了5个主要成分。这些成分在数量上是可变的,分别是香芹酚(71.03;47,17和11,84 %),γ-姜黄素(12,95;20.27和13.24%),胸腺醌(1.58;11.50和33.82%),雪松(6.48;7.76和16.64%)和4-松油醇(2.03;3.09和3.83%)。
{"title":"Étude comparative de la composition chimique des huiles essentielles de Tetraclinis articulata (Vahl) Masters du Maroc","authors":"M. Bourkhiss, A. Chaouch, M. Ouhssine, B.Bourkhiss","doi":"10.3166/PHYTO-2018-0082","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0082","url":null,"abstract":"La qualité et la variabilité de la composition chimique de l’huile essentielle isolée de tronc de Tetraclinis articulata ont été étudiées dans trois régions bien représentatives dans la tétraclinaie marocaine. Les rendements moyens obtenus par hydrodistillation sont de 1,10 % pour la région de Debdou (Maroc oriental), 2,70 % pour Essaouira nord (Haut Atlas) et 1,45 % pour Ben Karrich (Rif occidental). L’analyse par CPG et GC/MS a permis de mettre en évidence cinq constituants majoritaires dans chaque localité. Ces constituants présentent une variabilité quantitative et sont, respectivement, le carvacrol (71,03 ; 47,17 et 11,84 %), le γ-curcumène (12,95 ; 20,27 et 13,24 %), la thymoquinone (1,58 ; 11,50 et 33,82 %), le cédrol (6,48 ; 7,76 et 16,64 %) et le 4-terpinéol (2,03 ; 3,09 et 3,83 %).","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48311346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Chemical Profile, in vitro Antibacterial and Antioxidant Activities ofJuniperus phoeniceaL. and Cotula cinerea (Del.) Essential Oils from Southwestern Algeria 刺柏的化学性质、体外抗菌和抗氧化活性。和花椰菜(Del.)阿尔及利亚西南部的精油
Q4 Medicine Pub Date : 2018-10-25 DOI: 10.3166/PHYTO-2018-0061
D. Ghouti, H. A. Lazouni, A. Moussaoui, D. C. Sari
This work aims to study the chemical composition, antimicrobial and antioxidant activities ofJuniperus phoeniceaL. andCotula cinerea(Del.) essential oils from southwestern Algeria. The hydrodistilled oils obtained were characterized by gas chromatography–mass spectrometry (GC– MS). A total of 45 and 25 compounds were identified representing 100% ofJuniperus phoeniceaL. andCotula cinerea(Del.) respectively. The dominant component was α-pinene (46.437%) forJuniperus phoeniceaL. and α-thujone (32.35%) forCotula cinerea(Del.). The in vitro antibacterial activity of the essential oils was evaluated against nine foodborne pathogenic bacteria and one yeast, Candida albicans, using the disk diffusion method; the minimum inhibitory concentration (MIC) values were examined (micro dilution). The results suggest that the essential oil ofJuniperus phoeniceahas a significant to moderate antibacterial activity on all strains of bacteria. The most sensitive strains were Bacillus cereus, Bacillus subtilis,Micrococcus luteus,Pseudomonas aeruginosa, andCandida albicanswith (MIC = 0.04 to 0.63 mg/ml).Cotula cinereaoil showed moderate to low sensitivity to the test strains. Its best activity was against Bacillus subtilis (MIC = 0.303 mg/ml). The DPPH test conducted to evaluate the antioxidant activity of both oils showed a good to moderate capacity forJuniperus phoeniceaL. (concentration of an inhibitor when the response is reduced by half, IC50 = 0.76 mg/ml) andCotula cinerea(Del.) [IC50 = 28. mg/ml] oils respectively. The promising bioactivities of these plants suggest that they may be a new source of preservative molecules.
本研究旨在研究刺柏的化学成分、抑菌活性和抗氧化活性。以及产自阿尔及利亚西南部的油葵精油(cotula cinerea)。采用气相色谱-质谱联用(GC - MS)对所得的水蒸馏油进行了表征。共鉴定出45和25个化合物,代表了100%的刺柏成分。和花椰菜(Del.)。刺柏的主要成分为α-蒎烯(46.437%)。α-图琼(32.35%);采用圆盘扩散法对9种食源性致病菌和1种酵母菌白色念珠菌进行体外抑菌活性评价;测定最小抑菌浓度(MIC)值(微稀释)。结果表明,杜松精油对各种细菌均有较强的抑菌活性。最敏感菌株为蜡样芽孢杆菌、枯草芽孢杆菌、黄体微球菌、铜绿假单胞菌和白色念珠菌,MIC值为0.04 ~ 0.63 mg/ml。黄连油对试验菌株的敏感性为中~低。其抗枯草芽孢杆菌活性最高(MIC = 0.303 mg/ml)。通过DPPH试验对两种精油的抗氧化能力进行评价,结果表明两种精油的抗氧化能力均为良好至中等水平。(反应降低一半时抑制剂的浓度,IC50 = 0.76 mg/ml)和黄皮草(Del.) [IC50 = 28。Mg /ml]油。这些植物具有良好的生物活性,可能是防腐剂分子的新来源。
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引用次数: 5
Chemical Composition and Antimicrobial Activity of the Saharo-endemic Species: Ammodaucus leucotrichus subsp. leucotrichus Coss & Dur (Apiaceae) 撒哈拉特有种白毛杉亚种的化学成分及抑菌活性。白毛茛(蜂科)
Q4 Medicine Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0079
M. Touaibia, F. Saidi, D. Abdellali, F. Z. Raber Elmaizi
Essential oil of Ammodaucus leucotrichus subsp. leucotrichus Coss & Dur (endemic), extracted from the seeds by hydrodistillation, was screened for its possible antimicrobial activity as well as its chemical composition. According to the Gas Chromatography/Mass Spectrometry analysis, 35 components were identified (98.23%), perillaldehyde (45.58%) and limonene (14.02%) being the major components. The antimicrobial test of the essential oil showed that Staphylococcus aureus (MIC = 4.5 mg/ml) and Bacillus cereus (MIC = 9 mg/ml) were the most sensitive strains, followed by Candida krusei and Candida albicans (MIC = 18 mg/ml both).
白毛杉精油。采用加氢蒸馏法提取白毛菌(leucotrichus Coss & Dur),对其抑菌活性和化学成分进行了筛选。经气相色谱/质谱分析,共鉴定出35种成分(98.23%),其中紫苏醛(45.58%)和柠檬烯(14.02%)为主要成分。精油抑菌试验结果显示,金黄色葡萄球菌(MIC = 4.5 mg/ml)和蜡样芽孢杆菌(MIC = 9 mg/ml)对其最敏感,其次为克鲁氏念珠菌和白色念珠菌(MIC均为18 mg/ml)。
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引用次数: 2
Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L. 摩洛哥蛇麻草的神经药理特征及化学分析。
Q4 Medicine Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0058
Ghizlane Hajjaj, A. Bahlouli, M. Tajani, K. Alaoui, Y. Cherrah, A. Zellou
Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and psychopharmacological profile of the essential oil and aqueous extract from Ormenis mixta L. by using behavioral tests in vivo, at graded doses. The result of this research shows that Ormenis mixta L. was safe up to 2 g/kg b.w. (body weight) in the acute toxicity study, possesses potential psychostimulant effect, and has antianxiety and antidepressant-like activity. This activity profile of Ormenis mixta L. was similar to the typical psychostimulant, caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. These results explained the extensive use of Ormenis mixta L. as a traditional medicine in Morocco.
Ormenis mixta L.传统上用于治疗中枢神经系统(CNS)相关疾病。它的抗应激特性在摩洛哥传统医学和芳香疗法中受到关注。然而,摩洛哥尚未对这种植物进行药理学研究。本研究通过体内行为测试,在分级剂量下,对青藤精油和水提取物进行了初步的植物化学筛选和心理药理学研究。本研究结果表明,在急性毒性研究中,Ormenis mixta L.的安全性高达2g/kg体重,具有潜在的精神刺激作用,并具有抗焦虑和抗抑郁活性。Ormenis mixta L.的这种活性特征与典型的精神刺激剂咖啡因相似。这种类似兴奋剂的作用的确切机制应该通过进一步的详细研究来阐明。这些结果解释了Ormenis mixta L.作为传统药物在摩洛哥的广泛使用。
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引用次数: 1
Antioxidant Activity and Determination of Gallic Acid and Quercetin in Osyris alba L. Root Extract. The Root Oil Contains Essential Fatty Acids Osyris alba L.根提取物抗氧化活性及没食子酸和槲皮素含量的测定。根油含有必需脂肪酸
Q4 Medicine Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0072
D. Khaldi, Meriem Belarbi, I. E. Haci, F. Atik, W. Zeriouh, F. Z. Ghanemi, A. Nani, A. Hichami
Osyris alba L. (Santalaceae) is a shrub that grows wildly in southern Europe, North Africa and South-west Asia. In Algeria, the decoction of the root bark of this plant has been used since ancient times in folk medicine by the local population in the region of the mountains of Béni- Snousse (South west of Tlemcen), as a fortifying, antianaemic and as an anti-inflammatory agent. The aim of this work was to evaluate the antioxidant activity of the phenolic compounds of the root by using DPPH, FRAP, TAC methods. Determination of the phenolic profile of the root extract was assessed using HPLC-DAD technique (High Performance Liquid Chromatography-Diode Array Detection). While the determination of total fatty acid composition of the root oil was performed using Gas Chromatography (GC-FID). From the results, the total poly-phenol extract of the root bark has shown the highest antioxidant power which exceeds the standard, namely, ascorbic acid and Trolox. The chromatographic analysis of the total poly-phenol extract has found that the Gallic acid and Quercetin are the major compounds. These results demonstrate that the phenolic compounds of Osyris alba root bark have a great potential as sources for natural health products. Gaseous Chromatography Assay of the oil has revealed the presence of two groups of fatty acids: arachidic acid (C20:0) and linoleic acid (C18: 9.12) known for its pro-inflammatory effect against oleic acid C18:1, linolénic acid C18: 9.12.15, and eicosatrienoic acid (ETA) C20:3 which are known for their pro-anti-inflammatory effect. For this reason, we need to test the effect of this oil on inflammatory models.
欧树是一种灌木,广泛生长于南欧、北非和西南亚。在阿尔及利亚,这种植物的根皮煎液自古以来就被Béni-Snousse山区(特列姆岑西南部)的当地居民用于民间医学,作为一种强化、抗naemic和抗炎剂。本研究的目的是用DPPH、FRAP、TAC等方法评价根中酚类化合物的抗氧化活性。使用HPLC-DAD技术(高效液相色谱二极管阵列检测)来评估根提取物的酚类成分的测定。同时使用气相色谱法(GC-FID)测定根油的总脂肪酸组成。从结果来看,根皮的总多酚提取物显示出最高的抗氧化能力,即抗坏血酸和特洛氧。对总多酚提取物进行了色谱分析,发现没食子酸和槲皮素是主要的化合物。这些结果表明,白叶树树皮中的酚类化合物作为天然保健品的来源具有很大的潜力。该油的气相色谱分析显示存在两组脂肪酸:花生酸(C20:0)和亚油酸(C18:9.12),以其对油酸C18:1、亚麻酸C18:9.12.15和二十碳三烯酸(ETA)C20:3的促炎作用而闻名,这两种脂肪酸以其促抗炎作用而闻名。因此,我们需要测试这种油对炎症模型的影响。
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引用次数: 1
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Phytotherapie
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