Simpson's Political Illiberalism restores to its proper place in political theory Plato's thesis that bad music imperils the whole culture and polity, a thesis ignored with utter recklessness in contemporary liberal practice and, for the most part, theory. But Simpson's elaboration of the thesis over-simplifies the characteristics of Bach's (and later) "modern" music that make it dangerous, somewhat in the way that the Providential "composing" of human history, with all its complexities, involves discord and danger. One such hazardous complexity is the addition of prophetic divine revelation ("Jerusalem") to the achievements of (divinely given) human reason exercised in natural science and philosophy ("Athens"). The eventual completion of revelation includes the lapidary "Render to Caesar ... " formula, the two poles of which our soi-disant liberal doctrines about public good characteristically reduce to one. These Notes, complementary to Simpson's book, suggest that such a unilateral prioritizing of public peace over truth is inherently prejudicial to the political community's more fundamental common good, a common good prejudiced also by parallel failings at the ecclesiastical pole.
{"title":"Truth and Complexity: Notes on Music and Liberalism","authors":"J. Finnis","doi":"10.1093/ajj/aux009","DOIUrl":"https://doi.org/10.1093/ajj/aux009","url":null,"abstract":"Simpson's Political Illiberalism restores to its proper place in political theory Plato's thesis that bad music imperils the whole culture and polity, a thesis ignored with utter recklessness in contemporary liberal practice and, for the most part, theory. But Simpson's elaboration of the thesis over-simplifies the characteristics of Bach's (and later) \"modern\" music that make it dangerous, somewhat in the way that the Providential \"composing\" of human history, with all its complexities, involves discord and danger. One such hazardous complexity is the addition of prophetic divine revelation (\"Jerusalem\") to the achievements of (divinely given) human reason exercised in natural science and philosophy (\"Athens\"). The eventual completion of revelation includes the lapidary \"Render to Caesar ... \" formula, the two poles of which our soi-disant liberal doctrines about public good characteristically reduce to one. These Notes, complementary to Simpson's book, suggest that such a unilateral prioritizing of public peace over truth is inherently prejudicial to the political community's more fundamental common good, a common good prejudiced also by parallel failings at the ecclesiastical pole.","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"62 1","pages":"119-124"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ajj/aux009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48983443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Truth and Politics: A Symposium on Peter Simpson's Political Illiberalism: A Defense of Freedom.","authors":"G. Bradley","doi":"10.1093/AJJ/AUX012","DOIUrl":"https://doi.org/10.1093/AJJ/AUX012","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"62 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUX012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coercion, Political Authority and the Common Good","authors":"P. Brady","doi":"10.1093/AJJ/AUX007","DOIUrl":"https://doi.org/10.1093/AJJ/AUX007","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"62 1","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUX007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48865384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Peter Simpson on “Illiberal Liberalism”","authors":"R. George","doi":"10.1093/ajj/aux013","DOIUrl":"https://doi.org/10.1093/ajj/aux013","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"62 1","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ajj/aux013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46952872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminari a carrec del Dr. Steven Wall de la University of Arizona sobre l'Autonomia com una perfeccio
亚利桑那大学史蒂文·沃尔博士关于“完美自治”的Carrec研讨会
{"title":"Autonomy as a Perfection","authors":"S. Wall","doi":"10.1093/AJJ/AUW012","DOIUrl":"https://doi.org/10.1093/AJJ/AUW012","url":null,"abstract":"Seminari a carrec del Dr. Steven Wall de la University of Arizona sobre l'Autonomia com una perfeccio","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"61 1","pages":"175-194"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUW012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60658567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Knowing the Natural Law: A Response to Steven Jensen","authors":"R. J. Matava","doi":"10.1093/AJJ/AUW014","DOIUrl":"https://doi.org/10.1093/AJJ/AUW014","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"61 1","pages":"237-257"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUW014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60658766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Failure of Joseph Raz’s Account of Legal Obligation","authors":"D. Mark","doi":"10.1093/AJJ/AUW013","DOIUrl":"https://doi.org/10.1093/AJJ/AUW013","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"61 1","pages":"217-236"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUW013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60658704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response and Rejoinder: On Voting, Intrinsic Evil, and Ranking of Political Issues","authors":"Cathleen Kaveny, K. Flannery","doi":"10.1093/AJJ/AUW010","DOIUrl":"https://doi.org/10.1093/AJJ/AUW010","url":null,"abstract":"","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"61 1","pages":"259-273"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/AJJ/AUW010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60658807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01Epub Date: 2016-04-06DOI: 10.1007/s12576-016-0441-8
Florin Iordache, Andrei Constantinescu, Eugen Andrei, Bogdan Amuzescu, Ferdinand Halitzchi, Lorand Savu, Horia Maniu
We characterized human amniotic fluid stem cells (AFSC) in senescent cultures (6 weeks) versus cryopreserved cells using whole-cell patch-clamp, immunophenotyping, and differential gene expression profiling for senescence genes. We evidenced five ion current components (outward rectifier, A-type, inward rectifier, and big conductance Ca2+-dependent K+ currents, fast voltage-dependent Na+ currents). Senescent AFSC showed reduced expression of CD90, CD44, CD133, over 500-fold increase of interferon gamma and telomerase reverse transcriptase genes, increased cycle-dependent kinase 4 inhibitors, p53-binding protein 1, and decreased calreticulin and CD44. HLA-ABC immune expression was similar, and HLA-DR expression very low in both cell types. A subset of cryopreserved AFSC featured large inward rectifier K+ currents, voltage-dependent Na+ currents, and neural progenitor markers evidenced by immunophenotyping and RT-PCR. In all AFSC, in both culture conditions, at patch rupture the outward currents were very low, and they increased progressively over several minutes upon cytoplasm dialysis with pipette solution.
{"title":"Electrophysiology, immunophenotype, and gene expression characterization of senescent and cryopreserved human amniotic fluid stem cells.","authors":"Florin Iordache, Andrei Constantinescu, Eugen Andrei, Bogdan Amuzescu, Ferdinand Halitzchi, Lorand Savu, Horia Maniu","doi":"10.1007/s12576-016-0441-8","DOIUrl":"10.1007/s12576-016-0441-8","url":null,"abstract":"<p><p>We characterized human amniotic fluid stem cells (AFSC) in senescent cultures (6 weeks) versus cryopreserved cells using whole-cell patch-clamp, immunophenotyping, and differential gene expression profiling for senescence genes. We evidenced five ion current components (outward rectifier, A-type, inward rectifier, and big conductance Ca<sup>2+</sup>-dependent K<sup>+</sup> currents, fast voltage-dependent Na<sup>+</sup> currents). Senescent AFSC showed reduced expression of CD90, CD44, CD133, over 500-fold increase of interferon gamma and telomerase reverse transcriptase genes, increased cycle-dependent kinase 4 inhibitors, p53-binding protein 1, and decreased calreticulin and CD44. HLA-ABC immune expression was similar, and HLA-DR expression very low in both cell types. A subset of cryopreserved AFSC featured large inward rectifier K<sup>+</sup> currents, voltage-dependent Na<sup>+</sup> currents, and neural progenitor markers evidenced by immunophenotyping and RT-PCR. In all AFSC, in both culture conditions, at patch rupture the outward currents were very low, and they increased progressively over several minutes upon cytoplasm dialysis with pipette solution.</p>","PeriodicalId":39920,"journal":{"name":"American Journal of Jurisprudence","volume":"3 1","pages":"463-476"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12576-016-0441-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82675569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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