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Serum Uric Acid Level in Preeclamptic Women Determine the Severity of Preeclampsia 子痫前期妇女血清尿酸水平决定子痫前期的严重程度
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48275
K. Nahar, Sayada Fatema Khatun, N. Khan
s: Background: Serum uric acid is a relatively insoluble metabolite of purine metalolism which is mainly secreted by the kidneys and the rate is dependant on renal blood flow . It increases in preeclampsia and studies show it may be marker of severe preeclampsia. Methods and materials: This cross sectional study was conducted in Dhaka Medical College Hospital in eclampsia ward of gynae & Obs department during the period from January 2010 to December 2011 with the objective to determine the serum uric acid level in preeclampsia, to compare the serum uric acid level between mild and sever preeclampsia and to find out any relationship of the serum uric acid level with hypertension in preeclampsia. The study group composed of 92 diagnosed case of preeclampsia patient. Out of the 92 cases, 42 had mild preeclampsia (group-A) and 50 had severe preeclampsia (group B). Result: The results of the study showed that the mean serum uric acid level was significantly higher in severe preeclampsia (6.91+1.02) compared to mild preeclampsia (4.99 + 0.80) and there is a positive and significant relationship of serum uric acid level with severity of hypertension in preeclampsia (p<.0001). Conclusion: There is significant association between serum uric acid level and severity of hypertension in Preeclampsia. Key word: Uric acid level in preeclampsia, Severity of preeclampsia. 1. Medical Officer, Department of Gynaecological Oncology, BSMMU. 2. Consultant, Department of Gynaecological Oncology, BSMMU. 3. Medical Officer, Department of Biochemistry and Molecular Biology, BSMMU. Address of Correspondence : Dr. Khairun Nahar, Medical Officer, Dept. of Obs & Gynae, BSMMU, Shahbag, Dhaka1000, Email: khairun_nahar58@yahoo.com, Mobile : 01717220429 Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2): 67-72
背景:血清尿酸是嘌呤代谢的一种相对不溶性代谢物,主要由肾脏分泌,其分泌速率依赖于肾血流量。它在子痫前期增加,研究表明它可能是严重子痫前期的标志。方法与材料:本横断面研究于2010年1月至2011年12月在达卡医学院附属医院子痫妇产科病房进行,目的是测定子痫前期患者血清尿酸水平,比较轻、重度子痫前期患者血清尿酸水平,探讨子痫前期患者血清尿酸水平与高血压的关系。研究组由92例确诊的先兆子痫患者组成。92例患者中,轻度子痫前期42例(a组),重度子痫前期50例(B组)。结果:研究结果显示,重度子痫前期患者血清尿酸均值(6.91+1.02)明显高于轻度子痫前期患者(4.99 + 0.80),且血清尿酸水平与子痫前期高血压严重程度呈正相关(p< 0.0001)。结论:血尿酸水平与子痫前期高血压严重程度有显著相关性。关键词:子痫前期尿酸水平子痫前期严重程度1. BSMMU妇科肿瘤科医务干事。2. BSMMU妇科肿瘤科顾问。3.BSMMU生物化学和分子生物学学系医务干事。通讯地址:Khairun Nahar医生,医生,妇产科医生,Shahbag, Dhaka1000, e - mail: khairun_nahar58@yahoo.com,手机:01717220429 Bangladesh J obet gynaol, 2017;Vol. 32(2): 67-72
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引用次数: 1
Evaluation of Nitric Oxide Concentrations in Preeclampsia and Normal Pregnancy 评估一氧化氮浓度在子痫前期和正常妊娠
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48274
S. Akter, F. Begum, S. Abbasi
During pregnancy Nitric oxide is one of the most important relaxing factors for myometrium and also in the control of blood flow in uterus and placenta. Nitric oxide is generated by endothelial type II nitric oxide synthase (NOS) and acts as a vasodilator. Objective:To investigate the level of nitric oxide (NO) production in pregnancies complicated by preeclampsia and in normal pregnancy. Materials and Methods: A case control study was undertaken in Department of Gynaecology and Obstetrics of Bangabandhu Sheikh Mujib Medical University (BSMMU), from january to july 2014. The study population was pregnant women having preeclampsia and normal pregnancy who attended the OPD Department of Obstetrics and Gynecology in BSMMU between 29 to 40 weeks of gestation. As because of transient and volatile nature of nitric oxide, it was unsuitable to measure the nitric oxide level by conventional method. However, two stable break down product, nitrate (NO3 -) and nitrate (NO2 -) could be easily detected by sprectophototric means. Nitrate (NO2 -) was first converted to Nitrite (NO3 -) by reduction process using cadmium. Then concentration was measured by using Griess reagent in UV sprectophototric machine. This procedure was done in the Biochemistry Department, Dhaka University. Results: The mean nitrite level was found 18.37±3.64 mol/L in case group and 25.57±2.11mol/ L in control group, which was significantly (p<0.05) higher in control group. The mean serum creatinine level was found 1.19±0.28 mg/dl in case group and 0.65±0.1 mg/dl in control group. The mean serum creatinine level was significantly (p<0.05) higher in case groups. Nitrite level had no correlation with onset of hypertension (r=-0.006; p=0.966), onset of proteinuria (r=0.071; p=0.623), systolic blood pressure (r=0.012; p=0.933), diastolic blood pressure (r=-0.159; p=0.269) and urine protein (r=0.047, p=0.748). Conclusion: As pregnancy progressed there was a decrease in plasma nitric oxide levels in preeclampsia. Urine uric acid to creatinine ratio increased with the decrease in nitric oxide levels and can be used as a marker for preeclampsia.
在妊娠期间,一氧化氮是子宫肌层最重要的放松因素之一,也是控制子宫和胎盘血流的重要因素。一氧化氮由内皮II型一氧化氮合酶(NOS)产生,并起到血管舒张剂的作用。目的:探讨妊娠合并子痫前期和正常妊娠期一氧化氮(NO)的产生水平。材料和方法:2014年1月至7月,在班加班杜谢赫·穆吉布医科大学妇产科进行病例对照研究。研究人群是患有先兆子痫和正常妊娠的孕妇,她们在妊娠29至40周期间到BSMMU的妇产科门诊就诊。由于一氧化氮的瞬态和挥发性,不适合用常规方法测量一氧化氮水平。然而,两种稳定的分解产物,硝酸盐(NO3-)和硝酸盐(NO2-)可以很容易地通过扩散光电手段检测到。硝酸盐(NO2-)首先通过使用镉的还原过程转化为亚硝酸盐(NO3-)。然后用Griess试剂在紫外分光光度计上测定浓度。该程序在达卡大学生物化学系完成。结果:病例组平均亚硝酸盐含量为18.37±3.64mol/L,对照组为25.57±2.11mol/L,均高于对照组(p<0.05)。病例组的平均血清肌酐水平为1.19±0.28 mg/dl,对照组为0.65±0.1 mg/dl。病例组的平均血清肌酸酐水平显著升高(p<0.05)。亚硝酸盐水平与高血压发作(r=-0.006;p=0.966)、蛋白尿发作(r=0.071;p=0.623)、收缩压(r=0.012;p=0.933)、舒张压(r=-0.159;p=0.269)和尿蛋白(r=0.047,p=0.748)无相关性。尿尿酸与肌酐的比值随着一氧化氮水平的降低而增加,可作为先兆子痫的标志物。
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引用次数: 2
Abstract Vol.32(2) 文摘Vol.32 (2)
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48287
S. Khatun
Abstract Not Available Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 128-129
Abstract Not Available Bangladesh J Obstet Gynaecol,2017;第32卷(2):128-129
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引用次数: 0
Advantages of “Life Curve” Mobile Application: An Easier Alternate of Paper Partograph “生命曲线”移动应用程序的优势:一种更容易替代纸质版的应用程序
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48278
F. Begum, Sahariar Hossain Tanvir, Jahid Hasan
Background: The WHO approved paper Partograph is a time tested tool for monitoring the progression of labour to reduce life-threatening complications during labour as well as maternal mortality and morbidity. However, inept manpower for recording and interpreting data, chance of retrograde plotting and limited scope of distance monitoring have become a significant barriers to use this tool. The ‘Life Curve’, an Android Apps, is put forward as an easier alternate of the paper partograph.
背景:世卫组织批准的纸质分娩是一种经过时间考验的工具,用于监测分娩进展,以减少分娩期间危及生命的并发症以及孕产妇死亡率和发病率。然而,记录和解释数据的人力不足,逆行绘图的可能性以及有限的远程监测范围已成为使用该工具的重大障碍。“生命曲线”,一个Android应用程序,被提出作为一个更容易的替代纸的段落。
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引用次数: 0
Preeclampsia 子痫前期
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48273
T. Parveen
Abstract not available Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 58-59
孟加拉妇产科杂志,2017;Vol. 32(2): 58-59
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引用次数: 0
Risk Factors and Outcome of Preterm Labour in Tertiary Health Centre 三级卫生中心早产的危险因素及结局
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48279
M. A. Khanum, Salma Lavereen, Moniruzzaman, Romana
Background: Currently preterm labour is one of the most challenging problems confronting the obstetricians and perinatologists. This unfortunate episode accounts for 50-75% of the perinatal mortality. Methods: A cross sectional study was conducted on 210 pregnant women with preterm labour admitted in Monno Medical College Hospital, Manikganj from June 2014 to December 2015, to study the causes and outcome of preterm birth in Tertiary health centre of Manikganj. Results: Occurence of preterm birth was 13.82%; 47.14% occured between 34-37 weeks of gestation; 33.80% occured 31-33 weeks of gestation and occurred in 28-30 weeks 19.04%. About 22% patients presenting with preterm labour had a past history of abortions and 14.3% had a history of preterm delivery. Premature rupture of membranes was found to be the most common risk factor related with preterm labour in the present pregnancy. Genitourinary tract infection was the next important risk factor of preterm labour; 24.8% (86) patients had either vaginal infection (19.5%) or urinary infection (21.4%) or both. Another important risk factor identified in this study was antepartum haemorrage which was cause in 11.4 % cases. Preterm babies commonly suffered from various complications like jaundice (32.1%), respiratory distress syndrome (22.6%), asphyxia (13.5%), sepsis, hypoglycemia and coagulopathy. Conclusion: Most of the preterm births occured between 34-37 weeks of gestation. Most common risk factors of preterm births are history of abortion and preterm delivery in previous pregnancy; PROM UTI vaginal infection, PIH and APH in correct pregnancy. Newborn jaundice, RDS and birth asphyxia are the common neonatal morbidity in preterm labour. Identifying risk factors to prevent the onset of preterm labour and advanced neonatal care unit can help decrease neonatal morbidity and mortality.
背景:目前早产是产科医生和围产期医生面临的最具挑战性的问题之一。这一不幸事件占围产期死亡率的50-75%。方法:对2014年6月至2015年12月入住马尼克甘吉蒙诺医学院医院的210名早产孕妇进行横断面研究,以研究马尼克甘杰三级卫生中心早产的原因和结果。结果:早产发生率为13.82%;47.14%发生在妊娠34~37周;33.80%发生在妊娠31-33周,发生在28-30周19.04%。约22%的早产患者有流产史,14.3%有早产史。胎膜早破是目前妊娠期与早产相关的最常见的危险因素。生殖道感染是早产的下一个重要危险因素;24.8%(86)的患者有阴道感染(19.5%)或泌尿系统感染(21.4%)或两者兼有。本研究中确定的另一个重要风险因素是产前出血,11.4%的病例是由该因素引起的。早产儿常见各种并发症,如黄疸(32.1%)、呼吸窘迫综合征(22.6%)、窒息(13.5%)、败血症、低血糖和凝血障碍。结论:早产多发生在孕34~37周。早产最常见的危险因素是流产史和前一次妊娠的早产;PROM UTI阴道感染、正确妊娠中的PIH和APH。新生儿黄疸、RDS和出生窒息是早产中常见的新生儿发病率。识别预防早产的风险因素和高级新生儿护理病房有助于降低新生儿发病率和死亡率。
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引用次数: 2
Iatrogenic Rupture Uterus with Bowel Prolapse – Missmanaged Third Stage of Labour 医源性子宫破裂伴肠脱垂——第三产程处理不当
Pub Date : 2020-07-19 DOI: 10.3329/bjog.v32i2.48285
S. Nahar, Nasren Akther, Palash Kumar Dav, M. Sultana, Dilip Kumar Kundu
We present a case of mismanaged 3rd stage of labour by untrained dai who delivered the patient by injudicious administration of uterotoric drug and tried to remove the placenta manually with excavation of the small intestine through vagina. Every women present a unique challenge during her pregnancy and delivery period, unfortunately a significant number will have medical and surgical problems which will complicate their pregnancy and puerperal period, develop such serious condition that the lives of both mother and their unborn baby will be threatened. The aim of this case presentation are to ensure the ANC for every women and facilitate to make informed decision concerning where they will be seen, who will undertake the case, which screening test to be done, where they plan to give birth and where she will achieve full facility for safe delivery. These helps to prevent the catastrophic complications. Key ward: Mismanaged third stage of labour, Complication of third stage of labour Bangladesh J Obstet Gynaecol Vol. 32, No. 2 125 of uterotonic drug followed by ruptured uterus and extraction of small bowel through the ruptured site during an attempt of manual removal of placenta.
我们报告一例未受过专业训练的产科医生在分娩第三阶段处理不当,不明智地使用了子宫收缩药物,并试图通过阴道挖掘小肠手动取出胎盘。每个妇女在怀孕和分娩期间都面临着独特的挑战,不幸的是,相当多的妇女将面临医疗和手术问题,这将使她们的怀孕和产褥期复杂化,病情严重到母亲和未出生婴儿的生命都将受到威胁。介绍这一病例的目的是确保每位妇女都能接受产前检查,并有助于在知情的情况下决定在哪里就诊、由谁负责接生、进行哪种筛查、计划在哪里分娩以及在哪里有安全分娩的充分设施。这有助于预防灾难性的并发症。重点病房:第三产程处理不当,第三产程并发症孟加拉国《妇产科杂志》第32卷第2期125例子宫强直药物后子宫破裂,并在尝试人工取胎盘时通过破裂部位取出小肠。
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引用次数: 0
Active Management of the Third Stage of Labour: A Brief Review and Update 劳动第三阶段的积极管理:简评与更新
Pub Date : 2020-07-05 DOI: 10.3329/bjog.v33i2.43571
N. Sultana, F. Begum, S. Shermin
Blood loss due to postpartum haemorrhage (PPH) and its complications constitute one ofthe major causes of maternal mortality and morbidity. Active management of third stage oflabour (AMTSL) plays an immense role in preventing maternal death due PPH. But till dateobstetricians all over the world and the concerned international bodies could not reach to asingle agreement about its universal use. This approach is practiced widely in many centresand there are some specific guidelines regarding its practical use. AMTSL as a prophylacticintervention and is composed of a package of three components or steps: 1) administrationof a uterotonic, preferably oxytocin, immediately after birth of the baby; 2) controlled cordtraction (CCT) to deliver the placenta; and 3) massage of the uterine fundus after the placentais delivered. In 2012, the results of a large WHO-directed, multi-centred clinical trial showedthat the most important AMTSL component was the administration of an uterotonic, theother two steps contributes relatively less in blood loss. But WHO recommends to continueall three steps of AMTSL for management and training of third stage of labour. This article isa brief review of the recent guidelines and evidence based practice of active management ofthe third stage of labour. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(2) : 149-156
产后出血引起的失血及其并发症是导致产妇死亡和发病的主要原因之一。积极管理妊娠第三阶段(AMTSL)在预防PPH引起的孕产妇死亡方面发挥着巨大作用。但迄今为止,世界各地的产科医生和有关国际机构未能就其普遍使用达成一致。这种方法在许多中心得到了广泛的实践,并且有一些关于其实际使用的具体指南。AMTSL是一种预防性服务,由三个成分或步骤组成:1)在婴儿出生后立即给予子宫内补剂,最好是催产素;2) 控制绳索牵引(CCT)递送胎盘;和3)在胎盘分娩后对子宫底部进行按摩。2012年,一项以世界卫生组织为导向的多中心大型临床试验的结果表明,AMTSL最重要的组成部分是子宫补药的给药,其他两个步骤对失血的贡献相对较小。但世界卫生组织建议继续实施AMTSL的三个步骤,用于第三阶段分娩的管理和培训。本文简要回顾了近年来积极管理第三产程的指导方针和循证实践。孟加拉国妇产科杂志,2018;第33卷(2):149-156
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引用次数: 0
B55 Fetus Papyraceous - A Case Report With Maternal Coagulopathy And Successful Maternal and Fetal Outcome 胎儿纸莎草病- 1例报告与母亲凝血功能障碍和成功的母婴结局
Pub Date : 2020-07-05 DOI: 10.3329/bjog.v33i2.43573
Mst Nazmunnaher Mina, F. Ara, Afroza Khanum, Tahsin Islam, S. Sultana, Ummul Nusrat Jahan, S. Begum
Fetus papyraceous is defined as a compressed fetus, mummified, parchment-like remainsof a dead twin or triplet that is retained in-utero after intrauterine death in the second trimester.We report a case of one fetus papyraceous with maternal coagulopathy and no maternaland fetal complications in the post-partum period. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(2) : 160-163
胎儿纸莎草样定义为妊娠中期宫内死亡后保留在子宫内的一对或三胞胎死亡后压缩的、木乃伊化的羊皮纸样胎儿遗骸。我们报告一例胎儿纸莎草病与产妇凝血功能障碍和没有产妇和胎儿并发症在产后时期。孟加拉国妇产科杂志,2018;Vol. 33(2): 160-163
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引用次数: 0
Society News Vol.33(2) 社会新闻第33卷(2)
Pub Date : 2020-07-05 DOI: 10.3329/bjog.v33i2.43576
S. Chowdhury
Abstract not available Bangladesh J Obstet Gynaecol, 2018; Vol. 33(2) : 171-172
摘要不可用孟加拉国妇产科杂志,2018;第33卷(2):171-172
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引用次数: 0
期刊
Bangladesh Journal of Obstetrics and Gynecology
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