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Schizophrenia and substance use disorder: a retrospective study of a dual diagnosis patients cohort 精神分裂症和物质使用障碍:双重诊断患者队列的回顾性研究
Q4 Medicine Pub Date : 2021-07-13 DOI: 10.5603/psych.2021.0021
Fabiana Ventura, M. Jesus, César S. Mendes, Carla Silva
Introduction: Approximately 47% of patients with Schizophrenia have criteria for a dual diagnosis. The consumption of illicit substances, particularly cannabis, is quite prevalent in these patients, being associated with an increase in mortality and morbidity and worse social outcomes. This study aims to understand the relationship between Schizophrenia and substance use disorders (SUD). Material and methods: A retrospective study was designed, including patients diagnosed with schizophrenia admitted to the Psychiatric Ward between January 2017 and June 2019. Results: 205 patients were included, 49 women (23.9%) and 156 men (76.1%). Of these, 29.1% consumed psychoactive substances at the first hospitalization, mainly cannabis (24.1%), with higher prevalence in men. The average age at the first admission was significantly lower for substance users than for non-users. The presence of consumption in the first hospitalization, the number of hospitalizations and treatment adherence were associated with the maintenance of consumption after the first hospitalization. The presence of consumption at the first hospitalization is a significant predictor of its maintenance. Patients who do not adhere to treatment were more likely to maintain consumption. The number of future hospitalizations was associated with early age at the first hospitalization, non-compliance to treatment and maintenance of consumption after the first hospitalization. Conclusions: We verify that the consumption of psychoactive substances is associated with the early age at the first hospitalization, whit the reduced compliance to treatment and the increased number of hospitalizations. Comorbid substance use disorders should be treated as early as possible to minimize the long-term effects of substance use on patients with schizophrenia in Dual Diagnosis programs.
引言:大约47%的精神分裂症患者具有双重诊断标准。非法物质,特别是大麻的消费在这些患者中相当普遍,这与死亡率和发病率的增加以及更糟糕的社会后果有关。本研究旨在了解精神分裂症与物质使用障碍(SUD)之间的关系。材料和方法:设计了一项回顾性研究,包括2017年1月至2019年6月入住精神病病房的被诊断为精神分裂症的患者。结果:205名患者包括在内,49名女性(23.9%)和156名男性(76.1%)。其中29.1%的患者在第一次住院时服用了精神活性物质,主要是大麻(24.1%),男性的患病率更高。药物使用者首次入院时的平均年龄明显低于非药物使用者。首次住院时的消费量、住院次数和治疗依从性与首次住院后消费量的维持有关。首次住院时是否存在消耗是其维持的重要预测因素。不坚持治疗的患者更有可能继续服用。未来住院人数与首次住院时的早期、首次住院后不遵守治疗和维持消费有关。结论:我们证实,精神活性物质的消费与首次住院时的年龄提前有关,而治疗依从性降低和住院人数增加。在双重诊断项目中,应尽早治疗合并物质使用障碍,以最大限度地减少物质使用对精神分裂症患者的长期影响。
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引用次数: 0
Omówienie wybranych metod współczesnej terapii schizofrenii
Q4 Medicine Pub Date : 2021-06-29 DOI: 10.5603/psych.a2021.0027
Karolina Michałowska, Emil Bartosz Rozenek, Alicja Cichocka, Bogumiła Szewczak, B. Król, N. Waszkiewicz
Schizophrenia is a mental disorder with a complex etiopathogenesis explained by several still developing theories. Knowledge of these theories can matter when choosing the right treatment, because it increases the chance of therapeutic success. Various strategies are currently being developed so that we can, to some extent, adapt therapy to the individual needs of patients and, thus, optimize the therapeutic effect and minimize side effects. The issue of personalization of therapy translates into better cooperation between the doctor and the patient. The involvement of both parts in the treatment process, as in the treatment of other mental disorders, is crucial for its effectiveness. The therapeutic methods that we have at our disposal are still not producing satisfactory results in reducing the negative symptoms or cognitive disorders that occur in schizophrenia. Currently, not only the development of psychiatry but also development of certain branches of science related to medicine, such as pharmacogenetics and molecular biology, can contribute to achieving satisfactory research results. It therefore seems reasonable to seek new treatment strategies. A brief presentation of the most promising therapeutic methods is the aim of this literature review. It covers pharmacological treatment (cariprazine, lurasidone, lumateperone, paliperidone), transcranial magnetic stimulation (TMS), psychotherapy and cognitive enhancement therapy (CET). The issue of pharmacogenetics of schizophrenia was also raised.
精神分裂症是一种具有复杂发病机制的精神障碍,有几种仍在发展中的理论可以解释。在选择正确的治疗方法时,了解这些理论很重要,因为它增加了治疗成功的机会。目前正在开发各种策略,以便我们能够在某种程度上使治疗适应患者的个人需求,从而优化治疗效果并将副作用降到最低。个性化治疗的问题转化为医患之间更好的合作。在治疗过程中,就像治疗其他精神障碍一样,这两个部分的参与对其有效性至关重要。我们现有的治疗方法在减少精神分裂症的负面症状或认知障碍方面仍然没有产生令人满意的结果。目前,不仅精神病学的发展,而且与医学有关的某些科学分支的发展,如药物遗传学和分子生物学,都有助于取得令人满意的研究成果。因此,寻求新的治疗策略似乎是合理的。简要介绍最有前途的治疗方法是这篇文献综述的目的。它涵盖了药物治疗(卡吡嗪,鲁拉西酮,lumateperone, palperidone),经颅磁刺激(TMS),心理治疗和认知增强治疗(CET)。精神分裂症的药物遗传学问题也被提出。
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引用次数: 0
Zastosowanie teorii ewolucji w obszarze psychoterapii 进化论在心理治疗中的应用
Q4 Medicine Pub Date : 2021-06-24 DOI: 10.5603/psych.a2021.0025
J. Przybyła
The article discusses the relationship between psychology and the theory of evolution. Particular attention was paid to those parts of psychological reflection that deal with topics that are also the area of interest of neuroscience. The article tries to show how the theory of evolution and its references to it, by searching for the adaptive function (or its breakdowns), in various phenomena, can constitute a platform for dialogue and understanding between psychology and neuroscience. It also shows which particular spheres of phenomena in the field of psychology and psychopathology are the subject of interest of all three fields of knowledge: psychology, neurobiology and evolutionary biology. In the opinion of the author of the article, the field of psychology that deals with these spheres both in theory and in therapeutic practice is psychodynamic psychotherapy and psychodynamic psychology.
本文讨论了心理学与进化论之间的关系。特别关注的是心理反思中涉及神经科学感兴趣的主题的部分。本文试图通过寻找各种现象中的适应功能(或其分解)来展示进化论及其参考,如何构成心理学和神经科学之间对话和理解的平台。它还显示了心理学和精神病理学领域中哪些特定的现象领域是心理学、神经生物学和进化生物学这三个知识领域感兴趣的主题。在本文作者看来,在理论和治疗实践中涉及这些领域的心理学领域是心理动力心理治疗和心理动力心理学。
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引用次数: 0
Znaczenie esketaminy w leczeniu depresji lekoopornej. Czy okaże się lekiem przełomowym? 维生素E在治疗耐药性抑郁症中的重要性。它会成为一种突破性药物吗?
Q4 Medicine Pub Date : 2021-06-24 DOI: 10.5603/psych.a2021.0026
Alicja Cichocka, Emil Bartosz Rozenek, Karolina Michałowska, Bogumiła Szewczak, N. Waszkiewicz
Esketamine opens a new chapter in treatment-resistant depression. It is used more and more often, because the therapeutic methods used so far do not provide fully satisfactory results. This article is a review of the most important information regarding the efficacy of esketamine and according to fighting depression and its influence on the glutamate system. The review also contains a short description of the most common adverse events, including the research of different stages of therapy on which they can appear. It turns out that appropriate influence on the glutamate system reduces symptoms of depression. Intranasal administration of esketamine quickly improves the condition of patients with treatment-resistant depression and reduces the risk of suicide. Long-term studies are still going on and their results should provide necessary information for improvement of this therapeutic method for treatment-resistant depression.
Es氯胺酮开启了抗治疗抑郁症的新篇章。它被越来越多地使用,因为迄今为止使用的治疗方法并没有提供完全令人满意的结果。本文综述了关于爱斯基摩胺疗效的最重要信息,并根据其对抗抑郁症及其对谷氨酸系统的影响进行了综述。该综述还简要描述了最常见的不良事件,包括对其可能出现的不同治疗阶段的研究。事实证明,对谷氨酸系统的适当影响可以减轻抑郁症的症状。艾司他明的鼻腔给药可迅速改善难治性抑郁症患者的病情,并降低自杀风险。长期研究仍在进行中,其结果应为改进这种治疗难治性抑郁症的方法提供必要的信息。
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引用次数: 0
An ornithological walk to improve the well-being of mental health professionals during the COVID-19 pandemic: a pilot study 新冠肺炎大流行期间改善心理健康专业人员福祉的鸟类学散步:一项试点研究
Q4 Medicine Pub Date : 2021-06-18 DOI: 10.5603/PSYCH.A2021.0024
S. Murawiec, P. Tryjanowski, A. Nita
Introduction: The COVID-19 pandemic has changed many routines worldwide and has also affected the mental health of psychiatric patients and mental health professionals. One of the suggested methods for mental health improvement is more intensive contact with nature, including birdwatching as a hobby. Material and methods: After an ornithological walk in February 2021 for 5 psychiatrists and psychotherapists, in spite of unfavourable weather, all participants very positively evaluated the impact of birding on their well-being, mood and subjective evaluation of stress level. Results: Particularly important is an observation that the pandemic reality forced the whole society, including mental health professionals, to limit their behaviours and attitudes to very “adult” and responsible ones. Everyday life was reduced to functioning based on a very concrete approach to reality while abandoning activities that stimulate imagination (travels, theatre, arts). The ornithological walk allowed participants to abandon the pandemic reality and enter the space of playfulness, fantasies and childhood experiences. It enabled immersion in a friendly “mother-world” in which sensory perceptions proved to be important: smell, touch (“rush of air”), feeling of space. Birds were perceived not only as direct objects of observations but also as symbols of freedom, energy and lightness.  Conclusions: Despite the small group size, ornithological walks are recommended as a nature-based intervention exerting a positive influence on the mental health of psychiatrists and psychotherapists. It is also believed to positively affect the management of their patients, although this and many other aspects require further research.
简介:新冠肺炎大流行改变了世界各地的许多常规,也影响了精神病患者和心理健康专业人员的心理健康。建议的改善心理健康的方法之一是与大自然进行更深入的接触,包括将观鸟作为一种爱好。材料和方法:2021年2月,5名精神病学家和心理治疗师进行了鸟类学步行,尽管天气不利,但所有参与者都非常积极地评估了观鸟对他们的幸福感、情绪和压力水平的主观评估的影响。结果:特别重要的是,观察到疫情的现实迫使整个社会,包括心理健康专业人员,将他们的行为和态度限制在非常“成人”和负责任的行为和心态上。日常生活被简化为基于非常具体的现实方法的运作,同时放弃了激发想象力的活动(旅行、戏剧、艺术)。鸟类学行走让参与者放弃了疫情的现实,进入了嬉戏、幻想和童年体验的空间。它使人们能够沉浸在一个友好的“母亲世界”中,在这个世界中,感官感知被证明是重要的:气味、触摸(“空气的冲击”)、空间感。鸟类不仅被视为直接的观察对象,而且被视为自由、活力和轻盈的象征。结论:尽管团体规模较小,但建议将鸟类学散步作为一种基于自然的干预措施,对精神病学家和心理治疗师的心理健康产生积极影响。它也被认为会对患者的管理产生积极影响,尽管这一点和许多其他方面需要进一步研究。
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引用次数: 4
Wpływ pandemii COVID-19 na przebieg schizofrenii – przegląd literatury 新冠肺炎大流行对精神分裂症的影响——文献综述
Q4 Medicine Pub Date : 2021-05-05 DOI: 10.5603/PSYCH.A2021.0020
Patrycja Pabis, Joanna Smolarczyk-Kosowska, M. Piegza
This paper provides an overview of the impact the SARS-CoV-2 pandemic had on the schizophrenics and the course of their disease. We presented the factors increasing the risk of infection and mortality in these patients. We then focused on the means to reduce the risk of the relapse of schizophrenia, as well as on the assessment of stress level perceived in the study group. Furthermore, we analyzed the work-flow and organization of work in the institutionalized support facilities for patients suffering from schizophrenia. Additionally, we examined the pros and cons of using atypical drugs, clozapine in particular, in the schizophrenia treatment, and discussed the issue of telemedicine and long-distance medical advice, which proved vital in the times of the pandemic.
本文综述了SARS-CoV-2大流行对精神分裂症患者及其病程的影响。我们提出了增加这些患者感染和死亡风险的因素。然后,我们将重点放在降低精神分裂症复发风险的方法上,以及对研究组感知到的压力水平的评估上。此外,我们分析了精神分裂症患者的制度化支持设施的工作流程和工作组织。此外,我们审查了在精神分裂症治疗中使用非典型药物,特别是氯氮平的利弊,并讨论了远程医疗和远程医疗咨询问题,这在大流行时期证明是至关重要的。
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引用次数: 0
Association of fear of COVID-19 and preventive behaviors (PB) against COVID-19 in Iran 伊朗对新冠肺炎的恐惧与新冠肺炎预防行为(PB)的关联
Q4 Medicine Pub Date : 2021-03-25 DOI: 10.5603/PSYCH.A2021.0016
H. Mosazadeh, A. Charkazi, Maryam Ahmadi-Livani, A. Nori, Arezoo Foroughi, A. Rahimi, M. Ghelichi-Ghojogh, E. Kalteh, Bagher Pahlavanzadeh, R. B. Ozouni-Davaji, A. Rajabi
The world is currently experiencing a pandemic of COVID-19. The pandemic can impact on physical health and psychological health. Therefore, we conducted a web based cross-sectional study to evaluate Fear of COVID-19 and preventive behaviors against COVID-19 in a volunteer population of Golestan province, Iran, in May and June 2020. An online questionnaire, including Fear of COVID-19 Scale (FCV-19S) and preventive behaviors against COVID-19, was used to evaluate fear and preventive behaviors in population. The data were presented by mean and frequency. Multiple linear regression analysis was performed to identify factors associated with Fear of COVID-19 at a significant level of 0.05 in Stata 14. A total of 734 of 900 contacted individuals completed the survey, with a participation rate of 81.5%. A total the mean age of the participants was 33.97±10.68 years and 375 (51.9%) females. The mean Fear of COVID-19 score in the participants was 19.69±5.96. There was a significant positive correlation between Fear of COVID-19 and preventive behaviors (r=0.19, p < 0.001). Multiple linear regression analysis showed participants with perceived threat of COVID-19 higher, female, married participants, health worker staffs and with underlying diseases in participants were associated with Fear of COVID-19. The fear of COVID-19 in Iranian society is high, which indicates the need to pay attention to the mental health in pandemic conditions. Appropriate interventions can be designed and implemented according to the factors affecting fear. In addition, it should be noted that people with less fear are less likely to observe the COVID 19's preventative behaviors. These findings would need to be verified in larger population studies.
目前,世界正在经历一场新冠肺炎大流行。疫情可能影响身体健康和心理健康。因此,我们于2020年5月和6月在伊朗戈勒斯坦省的志愿者人群中进行了一项基于网络的横断面研究,以评估对新冠肺炎的恐惧和对新冠肺炎的预防行为。采用新冠肺炎恐惧量表(FCV-19S)和新冠肺炎预防行为在线问卷,对人群的恐惧和预防行为进行评价。数据以平均值和频率表示。进行多元线性回归分析,以确定与Stata 14中显著水平为0.05的新冠肺炎恐惧相关的因素。在900名接触者中,共有734人完成了调查,参与率为81.5%。参与者的平均年龄为33.97±10.68岁,女性375人(51.9%)。参与者对新冠肺炎的平均恐惧评分为19.69±5.96。对新冠肺炎的恐惧与预防行为呈显著正相关(r=0.19,p<0.001)。多元线性回归分析显示,新冠肺炎威胁感较高的参与者、女性、已婚参与者、卫生工作者和参与者中的潜在疾病与对新冠肺炎的恐惧相关。伊朗社会对新冠肺炎的恐惧程度很高,这表明需要关注疫情条件下的心理健康。可以根据影响恐惧的因素设计和实施适当的干预措施。此外,应该注意的是,恐惧感较低的人不太可能观察到2019冠状病毒病的预防行为。这些发现需要在更大规模的人群研究中得到验证。
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引用次数: 3
Psychoterapia: metoda leczenia prowadzona przez kobiety i dla kobiet? O zjawisku feminizacji w psychoterapii.
Q4 Medicine Pub Date : 2021-02-18 DOI: 10.5603/PSYCH.A2021.0002
A. Sterna, Władysław Sterna
There has occurred a significant change in psychotherapy for recent decades. Previously psychotherapy was mostly defined and conducted by men, nowadays in Poland, nearly 80% of psychotherapists are women. It can be seen as an indication of the ongoing feminization process. The authors are considering a possible impact of this change on the image of psychotherapy as well as on the way it is conducted. The „good patient” profile is analyzed to answer the question of whether it is becoming to be a women’s profile. Several reasons for this to occur are discussed — differences within the socialization process, defense mechanisms, and preferences for psychotherapy between men and women. In conclusion, a few clues for psychotherapists to consider were recommended.
近几十年来,心理治疗发生了重大变化。以前,心理治疗主要由男性定义和实施,如今在波兰,近80%的心理治疗师是女性。这可以看作是正在进行的女性化进程的一个迹象。作者正在考虑这种变化对心理治疗的形象以及其实施方式的可能影响。对“好病人”档案进行分析,以回答是否正在成为女性档案的问题。本文讨论了导致这种情况发生的几个原因——男女之间社会化过程、防御机制和心理治疗偏好的差异。总之,建议心理治疗师考虑一些线索。
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引用次数: 0
Stosowanie substancji psychoaktywnych i poziom zasobów osobistych wśród mężczyzn z zaburzeniami depresyjnymi – badanie pilotażowe 抑郁症男性精神活性物质的使用和个人资源水平的初步研究
Q4 Medicine Pub Date : 2020-12-28 DOI: 10.5603/PSYCH.A2020.0052
A. Kielan, M. Jaworski, Anna Mosiołek, Ł. Święcicki, Bożena Walewska-Zielecka
Introduction: Many of the symptoms of depression in men can be placed in the category of other mental health problems, such as substance abuse. Personal resources are important factors that can have a positive impact on the treatment of people affected by depression. The aim of the study was to analyze the use of alcohol and nicotine and the level of personal resources among men diagnosed with depression. Methods: A questionnaire consisted of six tests: test with sociodemographic variables, AUDIT Test, Fagerstrom Test, Emotion Control Scale, Generalized Self-Efficacy Scale and Life Satisfaction Scale. To ensure reliability that in the control group are only men without depression, an additional test for this group was added - Gotland Male Depression Scale (to exclude men with symptoms of depression in further analysis). Material: The test group consisted of men diagnosed with depressive disorders (F31 - in the phase of depression, F32 and F33) treated in the 2nd Department of Psychiatry of the Institute of Psychiatry and Neurology. The control group consisted of patients from randomly selected departments from four Warsaw hospitals. A total of 80 men were included into the pilot study, 40 in test group and 40 in control group. Ten men with symptoms of depression were excluded from the control group. Results: Assessment of physical health among responders was not significantly different between both groups. In test group over half of responders (55%, n = 22) declared weak mental health vs. only 7% (n = 2) in control group (p < .001). The level of nicotine and alcohol addiction was not significantly different between test and control group. Self-efficacy was significantly lower in test group, MD = -4.64, CI95 [-7.93; -1.35], p = .006. Satisfaction with life also had lower level in test group, MD = -4.87, CI95 [-8.02; -1.72], p = .003. No significant difference between both groups was confirmed for emotion control and its components. Conclusions: 1. Men with diagnosed depression assess their mental health lower than men without symptoms of this disorder; there is no difference in the case of physical health. 2. According to the present study, men with depression do not use alcohol and tobacco in a different way than men without this disorder; there are also no differences in their level of emotional control. 3. Men with depression have lower self-efficacy and satisfaction with life. 4. It is necessary to repeat this study on a larger sample of respondents, so that the results will be representative for the entire Polish male population.
引言:男性抑郁症的许多症状可以归入其他心理健康问题的范畴,如药物滥用。个人资源是可以对抑郁症患者的治疗产生积极影响的重要因素。这项研究的目的是分析被诊断为抑郁症的男性对酒精和尼古丁的使用以及个人资源的水平。方法:问卷由六项测试组成:社会人口学变量测试、AUDIT测试、Fagerstrom测试、情绪控制量表、广义自我效能感量表和生活满意度量表。为了确保对照组中只有没有抑郁症的男性,增加了一项针对该组的额外测试——Gotland男性抑郁症量表(在进一步分析中排除有抑郁症症状的男性)。材料:试验组由在精神病学和神经病学研究所第二精神科接受治疗的被诊断为抑郁症的男性(F31-处于抑郁症阶段,F32和F33)组成。对照组由来自华沙四家医院的随机选择科室的患者组成。共有80名男性被纳入试点研究,其中40人在试验组,40人在对照组。10名有抑郁症症状的男性被排除在对照组之外。结果:两组应答者的身体健康评估没有显著差异。在测试组中,超过一半的应答者(55%,n=22)宣布心理健康状况不佳,而对照组只有7%(n=2)(p<.001)。测试组和对照组之间的尼古丁和酒精成瘾水平没有显著差异。试验组的自我效能显著降低,MD=-4.64,CI95[7.93;-1.35],p=.006。试验组的生活满意度也较低,MD=-4.87,CI95【-8.02;-1.72】,p=.003。在情绪控制及其成分方面,两组之间没有显著差异。结论:1。患有抑郁症的男性对其心理健康的评估低于没有抑郁症症状的男性;在身体健康的情况下没有区别。2.根据目前的研究,患有抑郁症的男性与没有抑郁症的男性使用酒精和烟草的方式不同;他们的情绪控制水平也没有差异。3.患有抑郁症的男性自我效能感和生活满意度较低。4.有必要在更大的受访者样本中重复这项研究,以便结果对整个波兰男性人口具有代表性。
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引用次数: 0
Promazyna — klasyk wart ponownego odkrycia?
Q4 Medicine Pub Date : 2020-12-24 DOI: 10.5603/psych.2020.0042
Tomasz Tafliński
Modern psychopharmacology offers an ever wide spectrum of psychotropic drugs that are in practice clinical adjustment to individual needs. Clinical practice shows that next to pharmaceuticals of the new generation, it is important to remember about older drugs, well known and embedded in the memory of subsequent generations psychiatrists. Promazine, among the phenothiazine-derived neuroleptics, is effective in managing the symptoms of agitation and anxiety of various etiologies, including in elderly patients. Thanks to this, promazine is still widely used, provided that the patient is properly selected and treated. The purpose of this article is to discuss the clinical profile of promazine and its principles in psychiatric practice. A case report of a 62-year-old woman with agitation and anxiety treated with promazine is also provided.
现代精神药理学提供了一个广泛的精神药物,在实践中临床调整个人的需要。临床实践表明,除了新一代的药物之外,重要的是要记住那些被后世精神病学家熟知和铭记的老药物。丙嗪,在吩噻嗪衍生的抗精神病药中,对包括老年患者在内的各种病因的躁动和焦虑症状有效。由于这一点,丙嗪仍然被广泛使用,只要病人得到适当的选择和治疗。本文的目的是讨论丙嗪的临床概况及其在精神病学实践中的原则。还提供了一名用丙嗪治疗躁动和焦虑的62岁妇女的病例报告。
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引用次数: 0
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Psychiatria
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